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https://www.readbyqxmd.com/read/29133879/development-of-a-genetic-sensor-that-eliminates-p53-deficient-cells
#1
Jovan Mircetic, Antje Dietrich, Maciej Paszkowski-Rogacz, Mechthild Krause, Frank Buchholz
The TP53 gene fulfills a central role in protecting cells from genetic insult. Given this crucial role it might be surprising that p53 itself is not essential for cell survival. Indeed, TP53 is the single most mutated gene across different cancer types. Thus, both a theoretical and a question of significant practical applicability arise: can cells be programmed to make TP53 an essential gene? Here we present a genetic p53 sensor, in which the loss of p53 is coupled to the rise of HSV-TK expression. We show that the sensor can distinguish both p53 knockout and cells expressing a common TP53 cancer mutation from otherwise isogenic TP53 wild-type cells...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29118936/regulation-of-hsvtk-gene-by-endogenous-microrna-122a-in-liver-cell-lines-as-suicide-gene-therapy
#2
Maryam Ghanbari, Esmaeil Saberfar, Zahra Goodarzi, Hadi Lashini, Sahar Ghanbari, Mojtaba Karamimanesh, Kazem Baesi
Aim: Here, we use miR-122a that exhibits liver-specific expression for developing a post-transcriptional regulative system mediated by microRNAs. Background: Gene therapy with adenovirus (Ad) vectors that express herpes simplex virus thymidine kinase (HSVtk) and ganciclovir (GCV) have been suggested as a therapeutic strategy to cancer. However, Ad vectors injected into tumors are dispersed into the systemic circulation and transduce liver cells, resulting in severe hepatotoxicity...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29118508/treatment-of-unilateral-zone-i-cytomegalovirus-retinitis-in-acute-lymphoblastic-leukemia-with-oral-valganciclovir-and-intravitreal-ganciclovir
#3
Koushik Tripathy, Kanhaiya Mittal, Pradeep Venkatesh, Sameer Bakhshi, Rohan Chawla
Cytomegalovirus retinitis (CMVR) is an opportunistic infection seen in immunocompromised patients, especially suffering from acquired immune deficiency syndrome. It is uncommonly seen in hematological malignancies and in patients on immunosuppressants. The authors present a 12-year-old girl with unilateral CMVR who was on maintenance phase therapy for mixed phenotype (B/myeloid) leukemia. Serology for human immunodeficiency virus was negative. The child was successfully treated with oral valganciclovir and repeated intravitreal ganciclovir injections...
September 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29113291/treatment-of-advanced-gastrointestinal-cancer-with-genetically-modified-autologous-mesenchymal-stem-cells-treat-me-1-a-phase-i-first-in-human-first-in-class-trial
#4
Jobst C von Einem, Sylvia Peter, Christine Günther, Hans-Dieter Volk, Gerald Grütz, Christoph Salat, Oliver Stoetzer, Peter J Nelson, Marlies Michl, Dominik P Modest, Julian W Holch, Martin Angele, Christiane Bruns, Hanno Niess, Volker Heinemann
Purpose: This phase I, first in human, first in class clinical study aimed at evaluating the safety, tolerability and efficacy of treatment with genetically modified mesenchymal stromal cells (MSC) in combination with ganciclovir (GCV). MSC_apceth_101 are genetically modified autologous MSCs used as vehicles for a cell-based gene therapy in patients with advanced gastrointestinal adenocarcinoma. Experimental design: The study design consisted of a dose-escalation 3 + 3 design...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29071779/risk-factors-and-clinical-outcomes-of-pediatric-liver-transplant-recipients-with-post-transplant-lymphoproliferative-disease-in-a-multi-ethnic-asian-cohort
#5
James Guoxian Huang, Mervin Ye Qing Tan, Seng-Hock Quak, Marion Margaret Aw
BACKGROUND: We aimed to evaluate clinical characteristics, risk factors, and disease outcomes for liver transplant recipients (LTR) with post-transplant lymphoproliferative disease (PTLD) at our center. METHODS: Retrospective review of data of all pediatric LTR (1991-2015) was conducted. RESULTS: The overall incidence of PTLD was 16.4% (18/110), the majority (13/18) were early lesions, while 3/18 were polymorphic/monomorphic PTLD. The risk factors significant on univariate analysis were as follows: mean age (years) at transplant (1...
October 26, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29067732/a-novel-construction-of-lentiviral-vectors-for-eliminating-tumorigenic-cells-from-pluripotent-stem-cells
#6
Kanako Ide, Kaoru Mitsui, Rie Irie, Yohei Matsushita, Nobuhiro Ijichi, Soichiro Toyodome, Ken-Ichiro Kosai
The risk of tumor formation poses a challenge for human pluripotent stem cell (hPSC)-based transplantation therapy. Specific and total elimination of tumorigenic hPSCs by suicide genes has not been achieved because no methodology currently exists for testing multiple candidate transgene constructs. Here, we present a novel method for efficient generation of tumorigenic cell-targeting lentiviral vectors (TC-LVs) with diverse promoters upstream of a fluorescent protein and suicide genes. Our two-plasmid system achieved rapid and simultaneous construction of different TC-LVs with different promoters...
October 25, 2017: Stem Cells
https://www.readbyqxmd.com/read/29057508/impact-of-antiviral-prophylaxis-in-adults-ebv-seronegative-kidney-recipients-on-early-and-late-ptld-onset-a-retrospective-cohort-study
#7
Simon Ville, Berthe-Marie Imbert-Marcille, Marianne Coste-Burel, Claire Garandeau, Aurélie Meurette, Diego Cantarovitch, Magali Giral, Maryvonne Hourmant, Gilles Blancho, Jacques Dantal
Post-transplantation lympho-proliferative disorder (PTLD) pathogenesis is related to EBV infection. Mismatch with the donor (EBV D+/R-) is the main risk factor for both early PTLD (< 1 year post transplantation) and late (> 1 year). In these at-risk patients, the role of antiviral prophylaxis for preventing PTLD remains controversial. We analysed the impact of antiviral drugs given to prevent CMV disease in a mono-centric retrospective cohort of 73 adult kidney or kidney-pancreas EBV seronegative recipients, transplanted between 01/01/2000 and 01/01/2016...
October 23, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29054457/bilateral-vocal-cord-immobility-resulting-from-cytomegalovirus-pharyngitis-a-case-report
#8
Rumi Ueha, Takaharu Nito, Takao Goto, Taku Sato, Tetsuo Ushiku, Tatsuya Yamasoba
Human cytomegalovirus (CMV) is an infectious herpes virus present in approximately 50% of the world's population. Pharyngitis is an uncommon manifestation of CMV infection, and vocal cord immobility (VCI) following CMV pharyngitis is quite rare. An 83-year-old man with well-controlled diabetes mellitus and hypertension was admitted due to dyspnea, odynophagia, and dysphagia. Laryngeal fiberscopy revealed bilateral vocal cords almost fixed at the median position, with mucosal redness, swelling, and edema at the hypopharyngeal area...
October 17, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29050186/-influent-factors-for-treating-procedure-of-cytomegalovirus-retinitis-after-allogeneic-bone-marrow-hematopoietic-stem-cell-transplantation
#9
H Miao, J Hou
Objective: To explore clinical and laboratory factors that influencing treating procedure of cytomegalovirus retinitis (CMVR) after allogeneic bone marrow hematopoietic stem cell transplantation (HSCT). Methods: This is a retrospective case series study. A total of 9 CMVR patients (15 eyes) between January 2016 and March 2017 were included in this study. All patients received intravenous or oral ganciclovir, together with intravitreous injection of ganciclovir alone or combined with foscanet sodium. One day before the first injection, aqueous humor samples from the affected eyes were collected, and CMV-DNA and interleukin-8 (IL-8) level were examined...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29049190/chronic-active-epstein-barr-virus-infection-as-the-initial-symptom-in-a-janus-kinase-3-deficiency-child-case-report-and-literature-review
#10
REVIEW
Linqing Zhong, Wei Wang, Mingsheng Ma, Lijuan Gou, Xiaoyan Tang, Hongmei Song
RATIONALE: With the progress of sequencing technology, an increasing number of atypical primary immunodeficiency (PID) patients have been discovered, including Janus kinase 3 (JAK3) gene deficiency. PATIENT CONCERNS: We report a patient who presented with chronic active Epstein-Barr virus (CAEBV) infection but responded poorly to treatment with ganciclovir. DIAGNOSES: Next-generation sequencing (NGS) was performed, including all known PID genes, after which Sanger sequencing was performed to verify the results...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29044005/analysis-on-the-treatment-and-prevention-of-epidemic-conjunctivitis-in-108-cases
#11
Guangli Sun, Gang Su, Yanhui Bai, Huiqin Yang
To explore the treatment method and preventive measures on epidemic keratoconjunctivitis. 108 patients with epidemic keratoconjunctivitis who received treatment in our hospital from January, 2015 to September, 2015.were selected. These patients were treated with interferon eye drops, Ganciclovir ophthalmic gel, and alternating eye treatment of tobramycin-dexamethasone eye drops and diclofenac sodium eye drops. Meanwhile, health education was also performed among patients, so as to promote the recovery of the disease as soon as possible and to prevent the spread of the disease Among the 108 patients, there were 101 patients recovered...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29042868/characteristics-and-prognosis-of-hepatic-cytomegalovirus-infection-in-children-10-years-of-experience-at-a-university-hospital-in-korea
#12
Chae-Yeon Min, Joo Young Song, Su Jin Jeong
PURPOSE: Studies on cytomegalovirus (CMV) infections in immunocompetent children are lacking, and minimal information is available in the medical literature on hepatic manifestations and complications of CMV. The aims of this study were to evaluate the clinical characteristics, laboratory data, and prognosis of children with CMV hepatitis, and to investigate its prevalence at a single medical center in Korea over a 10-year period. METHODS: One hundred thirty-two children diagnosed with CMV infection based on specific markers (anti-CMV IgM, CMV polymerase chain reaction in blood and urine, or CMV culture of urine) were included in the study...
August 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29028408/tonic-pupil-in-cytomegalovirus-anterior-uveitis-in-an-immunocompetent-adult-male-a-case-report
#13
Kalpana Babu, Deepika C Parameswarappa, Bhagya Sudheer
PURPOSE: To report an interesting case of development of tonic pupil in an immunocompetent male with cytomegalovirus (CMV) anterior uveitis. METHODS: Retrospective case report Results: A 30-year-old Iranian healthy male was diagnosed to have Posner-Schlossman syndrome (OS). Aqueous tap was positive for CMV by multiplex Polymerase chain reaction (PCR). Adequate control of inflammation and Intraocular pressures (IOP) were achieved with topical steroids, ganciclovir gel, and antiglaucoma medications...
October 13, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29026734/cytomegalovirus-infection-under-a-hybrid-strategy-in-pediatric-liver-transplantation-a-single-center-experience
#14
Ryung Kim, Dai Joung, Sunghee Lee, Insook Jeong, Seak Hee Oh, Jung-Man Namgoong, Dae Yeon Kim, Kyung Mo Kim
PURPOSE: To evaluate the outcomes of a hybrid prophylactic strategy to prevent cytomegalovirus (CMV) disease in pediatric liver transplantation (LT) patients. METHODS: CMV DNAemia was regularly monitored by quantitative nucleic acid amplification test (QNAT) and was quantified in all children. CMV infection and disease were defined according to the International Consensus Guidelines. The hybrid strategy against CMV infection consisted of universal 3-week prophylaxis and preemptive treatment of intravenous ganciclovir regardless of the recipient's serostatus...
September 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29022526/cytomegalovirus-retinitis-and-hiv-case-reviews-from-kwazulu-natal-province-south-africa
#15
R Hassan-Moosa, T Chinappa, L Jeena, L Visser, K Naidoo
BACKGROUND: Retinal cytomegalovirus (CMV) infection is a common opportunistic infection and remains a significant contributor to visual loss in patients with AIDS. We highlight the poor outcomes of CMV retinitis in three HIV-infected patients who were initiated on antiretroviral therapy (ART). We conducted a retrospective chart review of advanced stage HIV-infected patients with known CMV retinitis.Case 1. A 37-year-old man, with a CD4+ cell count of 35 cells/µL, presented for ART initiation with a 5-month history of visual loss in his left eye...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29022282/analysis-of-five-cases-of-human-herpesvirus-6-myelitis-among-121-cord-blood-transplantations
#16
Toshimitsu Ueki, Kenichi Hoshi, Yuki Hiroshima, Masahiko Sumi, Naoaki Ichikawa, Masao Ogata, Takako Satou, Takahiro Fukuda, Hikaru Kobayashi
Reports of myelitis associated with human herpesvirus-6 (HHV-6) following allogeneic transplantation are rare. Of 121 cases of cord blood transplantation (CBT) performed at Nagano Red Cross Hospital, five cases (4.1%) of HHV-6 myelitis developed at around the time of engraftment. The major symptom identified in all five patients was superficial pain or pruritus linked to segmental levels of the spinal cord. Other identified symptoms were fever or low-grade fever in all five patients, autonomic nerve disorder in four patients, bladder and rectal disturbance in two patients, and extrapyramidal disorder in two patients...
October 11, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29020220/role-of-secondary-prophylaxis-with-valganciclovir-in-the-prevention-of-recurrent-cytomegalovirus-disease-in-solid-organ-transplant-recipients
#17
Bradley J Gardiner, Jennifer K Chow, Lori Lyn Price, Natalie E Nierenberg, David M Kent, David R Snydman
Background: Cytomegalovirus (CMV) is a major contributor to morbidity and mortality in solid organ transplant recipients (SOTR). Ganciclovir and valganciclovir are highly effective antiviral drugs whose role in primary prophylaxis and treatment of CMV disease is well established. The objective of this study was to examine the effect of secondary prophylaxis (SP) on the risk of relapse in SOTR following an episode of CMV disease. Methods: We performed a retrospective cohort study of SOTR from 1995-2015 and used propensity score based inverse probability of treatment weighting methodology to control for confounding by indication...
August 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28986189/prevention-of-cytomegalovirus-reactivation-in-haploidentical-stem-cell-transplantation
#18
Aimee E Hammerstrom, Lindsey R Lombardi, Sai Ravi Pingali, Gabriela Rondon, Julianne Chen, Denái R Milton, Roy F Chemaly, Richard E Champlin, Alison Gulbis, Stefan O Ciurea
Cytomegalovirus (CMV) infection can increase the morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Because of a higher degree of immunosuppression, haploidentical transplant recipients may be at an increased risk of viral infections, particularly CMV. We retrospectively analyzed 86 haploidentical HCT recipients at our institution to determine whether a more intensified antiviral strategy would reduce the incidence of CMV reactivation compared with a traditional antiviral prophylaxis regimen...
October 3, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28979335/incidence-of-ganciclovir-resistance-in-cmv-positive-renal-transplant-recipients-and-its-association-with-ul97-gene-mutations
#19
Hamid Reza Aslani, Shadi Ziaie, Jamshid Salamzadeh, Sara Zaheri, Fariba Samadian, Shayan Mastoor-Tehrani
Human cytomegalovirus (CMV) remains the most common infection affecting organ transplant recipients. Despite advances in the prophylaxis and acute treatment of CMV, it remains an important pathogen affecting the short- and long-term clinical outcome of solid organ transplant recipient. The emergence of CMV resistance in a patient reduces the clinical efficacy of antiviral therapy, complicates therapeutic and clinical management decisions, and in some cases results in loss of the allograft and/or death of the patient...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28975863/long-term-stability-of-ganciclovir-in-polypropylene-containers-at-room-temperature
#20
Nicolas Guichard, Pascal Bonnabry, Serge Rudaz, Sandrine Fleury
Purpose Ganciclovir is increasingly provided by hospital pharmacy production unit in a ready-to-use form, in order to improve the safety of healthcare workers and the efficiency of the organisation. The objective of this study was to develop a stability-indicating method to assay ganciclovir and determine the stability of ganciclovir in syringes (5 mg/mL) and infusion bags (0.25 and 5 mg/mL) at two different temperatures. Method Ganciclovir solutions (0.25 mg/mL and 5 mg/mL) in 0.9% sodium chloride were prepared in 50 mL polypropylene syringes or 100 mL polypropylene infusion bags and stored at 2-8℃ and 23-27℃...
January 1, 2017: Journal of Oncology Pharmacy Practice
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