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https://www.readbyqxmd.com/read/27923378/congenital-cytomegalovirus-related-intestinal-malrotation-a-case-report
#1
Claudia Colomba, Mario Giuffrè, Simona La Placa, Antonio Cascio, Marcello Trizzino, Simona De Grazia, Giovanni Corsello
BACKGROUND: Cytomegalovirus is the most common cause of congenital infection in the developed countries. Gastrointestinal involvement has been extensively described in both adult and paediatric immunocompromised patients but it is infrequent in congenital or perinatal CMV infection. CASE PRESENTATION: We report on a case of coexistent congenital Cytomegalovirus infection with intestinal malrotation and positive intestinal Cytomegalovirus biopsy. At birth the neonate showed clinical and radiological evidence of intestinal obstruction...
December 7, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27903977/dioscin-augments-hsv-tk-mediated-suicide-gene-therapy-for-melanoma-by-promoting-connexin-based-intercellular-communication
#2
Jianyong Xiao, Guangxian Zhang, Bin Li, Yingya Wu, Xijuan Liu, Yuhui Tan, Biaoyan Du
Suicide gene therapy is a promising strategy against melanoma. However, the low efficiency of the gene transfer technique can limit its application. Our preliminary data showed that dioscin, a glucoside saponin, could upregulate the expression of connexins Cx26 and Cx43, major components of gap junctions, in melanoma cells. We hypothesized that dioscin may increase the bystander effect of herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV) through increasing the formation of gap junctions. Further analysis showed that dioscin indeed could increase the gap junctional intercellular communication in B16 melanoma cells, resulting in more efficient GCV-induced bystander killing in B16tk cells...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27899387/activation-of-cytomegalovirus-corneal-endotheliitis-following-laser-in-situ-keratomileusis
#3
Tien-En Tan, Chui Ming Gemmy Cheung, Jodhbir S Mehta
A case of Cytomegalovirus (CMV) corneal endotheliitis following laser in-situ keratomileusis (LASIK) is presented. A 32-year-old man presented 3 weeks after uncomplicated myopic LASIK with unilateral LASIK flap oedema, interface fluid accumulation, keratic precipitates, anterior uveitis and raised intraocular pressure. Despite treatment with topical corticosteroids, he had 3 further recurrent episodes. Specular microscopy showed decreased endothelial cell density and aqueous humour. Polymerase chain reaction (PCR) testing was positive for CMV DNA...
November 29, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27888673/clinical-correlates-of-pp65-antigenemia-monitoring-in-the-first-months-of-post-kidney-transplant-in-patients-undergoing-universal-prophylaxis-or-preemptive-therapy
#4
Fabiana Rabe Carvalho, Rachel Ingrid Juliboni Cosendey, Cintia Fernandes Souza, Thalia Medeiros, Paulo Alexandre Menezes, Andrea Alice Silva, Jorge Reis Almeida, Jocemir Ronaldo Lugon
INTRODUCTION: Human cytomegalovirus (HCMV) is a major cause of morbidity in kidney transplant patients. OBJECTIVES: We aimed to study viral replication and serological response in the first months post kidney transplant in patients undergoing universal prophylaxis or preemptive therapy and correlate the findings with the clinical course of HCMV infection. PATIENTS AND METHODS: Independent from the clinical strategy adopted for managing HCMV infection, prophylaxis versus preemptive therapy, the pp65 antigenemia assay and serological response were assessed on the day of transplantation, and then weekly during the first three months of post-transplant...
November 23, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27871917/gonococcal-conjunctivitis-a-case-report-of-an-unusual-mode-of-transmission
#5
Anna Jo Bodurtha Smith, Samuel B Holzman, Reza Sedighi Manesh, Trish M Perl
BACKGROUND: Outside of the newborn period, development of gonococcal conjunctivitis is rare and predominantly occurs through auto-inoculation. We report an unusual case of gonococcal conjunctivitis in a young woman exposed through direct inoculation. CASE: A 19-year-old woman presented with purulent ocular discharge, severe pain, and decreased vision unresponsive to topical antibiotics or ganciclovir approximately 3 weeks after accidental ocular exposure to seminal fluid during unprotected oral sex...
November 18, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27849440/use-of-cidofovir-for-cytomegalovirus-disease-refractory-to-ganciclovir-in-solid-organ-recipients
#6
Hugo Bonatti, Costi D Sifri, Clara Larcher, Stefan Schneeberger, Camille Kotton, Christian Geltner
BACKGROUND: Solid organ transplantation (SOT) frequently is complicated by cytomegalovirus (CMV) infections. Cidofovir (CDV) is active against CMV, including many ganciclovir (GCV)-resistant mutants, but often is considered to be too nephrotoxic for use after organ transplantation. PATIENTS AND METHODS: Seven males and two females (median age 50.1 years), including two kidney/pancreas, four lung, one small bowel, and two hand recipients, received CDV for refractory CMV disease...
November 16, 2016: Surgical Infections
https://www.readbyqxmd.com/read/27831637/studies-on-the-interference-of-ganciclovir-to-hcv-liver-fibrosis
#7
J Li, C-W Pan, G-Y Zhou, L Zhuge, P-P Fang, L-X Jin, W Lin, X-Z Lin, Y Zheng
OBJECTIVE: To investigate the significance of the combined treatment with ganciclovir and interferon for patients with hepatitis C (HCV) liver fibrosis. PATIENTS AND METHODS: We retrospectively summarize 86 patients with hepatitis C treated in our hospital from October 2013 to October 2015. 49 cases, considered as control group, received combined treatment with α-interferon and ribavirin; 37 cases, considered as observation group, received combined treatment with ganciclovir and interferon...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27830553/use-of-thymidine-kinase-recombinant-adenovirus-and-ganciclovir-mediated-mouse-liver-preconditioning-for-hepatocyte-xenotransplantation
#8
Daniel Moreno, Leire Neri, Eva Vicente, Africa Vales, Rafael Aldabe
Hepatocyte transplantation is the best approach to maintain and propagate differentiated hepatocytes from different species. Host liver has to be adapted for transplanted hepatocytes productive engraftment and proliferation being required a chronic liver injury to eliminate host hepatocytes and provide a proliferative advantage to the transplanted hepatocytes. Most valuable mouse models for xenograft hepatocyte transplantation are based on genetically modified animals to cause a chronic liver damage and to limit host hepatocyte regeneration potential...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27819399/cytomegalovirus-encephalitis-in-a-hemodialysis-patient-a-rare-association
#9
Alberto Vera, Pablo Ruano, Esther Ortega, Borja Quiroga
Haemodialysis patients are at greater risk of infections than individuals not on dialysis due to their immunosuppressive state caused by several factors (uraemia, vascular access, inflammation, malnutrition). However, infections affecting the central nervous system are not frequent in this population. We present the case of a 77-year-old man with end-stage renal disease who was admitted to the emergency department for a decreased level of consciousness and fever. Although the initial clinical suspicion oriented to a urinary infection, the lack of improvement forced us to perform a lumbar puncture...
November 7, 2016: New Microbiologica
https://www.readbyqxmd.com/read/27815507/suppression-of-neointima-formation-by-targeting-%C3%AE-catenin-tcf-pathway
#10
Helen Williams, Sadie Slater, Sarah Jane George
Coronary artery disease is treated by vein grafting and stent implantation.  Late vein graft failure and restenosis of stented arteries reduces the success rates of these approaches and is caused by neointima formation. We have previously shown that Wnt proteins are upregulated during intimal thickening, and have speculated that these lead to activation of downstream genes with β-catenin/T-cell factor (TCF)-responsive promoters. In this study we aimed to provide evidence that β-catenin/TCF signalling promotes neointima formation and assess whether targeting this pathway has potential for reducing neointima formation...
November 4, 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27812392/periesophageal-pseudoaneurysms-rare-cause-of-refractory-bleeding-treated-with-transarterial-embolization
#11
Divyanshoo R Kohli, Rachit D Shah, Daniel J Komorowski, George B Smallfield
A 43-year-old female with history of systemic lupus erythematosus, prior cytomegalovirus esophagitis treated with ganciclovir, and long segment Barrett's esophagus (Prague class C8 M9) with high grade dysplasia treated with radiofrequency ablation presented to the hospital with hematemesis. An upper gastrointestinal endoscopy showed multiple esophageal ulcers with active arterial spurting which could not be controlled with endoscopic interventions including placement of hemostatic clips. An emergent angiogram demonstrated actively bleeding saccular dilations (pseudoaneurysms) in the esophageal branches of the lower thoracic aorta as well as left gastric artery for which gelfoam and coil embolization was initially successful...
2016: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/27807008/role-of-equilibrative-nucleobase-transporter-1-slc43a3-as-a-ganciclovir-transporter-in-the-induction-of-cytotoxic-effect-of-ganciclovir-in-a-suicide-gene-therapy-with-herpes-simplex-virus-thymidine-kinase
#12
Junji Furukawa, Katsuhisa Inoue, Kinya Ohta, Tomoya Yasujima, Yoshihisa Mimura, Hiroaki Yuasa
A suicide gene therapy using herpes simplex virus thymidine kinase (HSV-TK) with ganciclovir (GCV) has been under development as a tumor-targeted therapy; however, the mechanism of cellular GCV uptake, which is prerequisite in the therapy, has not been clarified. In an attempt to resolve this situation and gain information to optimize HSV-TK/GCV system for cancer therapy, we found that human equilibrative nucleobase transporter 1 (ENBT1) can transport GCV with a Michaelis constant of 2.75 mM in Madin-Darby canine kidney II (MDCKII) cells stably transfected with this transporter...
January 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27792721/-historical-review-of-kaposi-sarcoma-in-pre-haart-era-evolution-with-different-chemotherapy-schedules-and-remission-with-ganciclovir-use
#13
Patricia Volkow, Benedicte Jacquemin, Juan W Zinser, Rogelio Pérez-Padilla
: Ganciclovir has shown in vitro anti-human herpesvirus-8 activity, Kaposi sarcoma agent. We analyzed all Kaposi sarcoma patients from 1985 to 1996 pre-HAART era and identified Kaposi sarcoma/AIDS patients who achieved complete remission prior to HAART use. RESULTS: We saw 155 Kaposi sarcoma patients up to 1996, 150 with enough information, only 12 received ganciclovir, eight of them for ≥ 21 days; four died within 16 weeks of ganciclovir administration. We identified four male patients with extensive Kaposi sarcoma with complete remission achieved after ganciclovir for CMV end-organ disease...
October 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27791177/towards-a-transcriptome-based-theranostic-platform-for-unfavorable-breast-cancer-phenotypes
#14
Andrey S Dobroff, Sara D'Angelo, Bedrich L Eckhardt, Fortunato Ferrara, Daniela I Staquicini, Marina Cardó-Vila, Fernanda I Staquicini, Diana N Nunes, Kisu Kim, Wouter H P Driessen, Amin Hajitou, Lesley C Lomo, Marc Barry, Savitri Krishnamurthy, Aysegul Sahin, Wendy A Woodward, Eric R Prossnitz, Robin L Anderson, Emmanuel Dias-Neto, Ursa A Brown-Glaberman, Melanie E Royce, Naoto T Ueno, Massimo Cristofanilli, Gabriel N Hortobagyi, Serena Marchiò, Juri G Gelovani, Richard L Sidman, Wadih Arap, Renata Pasqualini
Inflammatory breast carcinoma (IBC) is one of the most lethal forms of human breast cancer, and effective treatment for IBC is an unmet clinical need in contemporary oncology. Tumor-targeted theranostic approaches are emerging in precision medicine, but only a few specific biomarkers are available. Here we report up-regulation of the 78-kDa glucose-regulated protein (GRP78) in two independent discovery and validation sets of specimens derived from IBC patients, suggesting translational promise for clinical applications...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27790727/durable-remission-of-both-multicentric-castleman-s-disease-and-kaposi-s-sarcoma-with-valganciclovir-rituximab-and-liposomal-doxorubicin-in-an-hhv-8-positive-hiv-negative-patient
#15
C Murphy, E Hawkes, F Chionh, G Chong
WHAT IS KNOWN AND OBJECTIVE: Human herpesvirus-8 (HHV-8)-positive, HIV-negative multicentric Castleman's disease is a rare lymphoproliferative disorder with no standardized treatment. Concurrent Kaposi's sarcoma, another HHV-8-related disease, is uncommon in HIV-negative patients. The role of antiviral therapy and rituximab in HIV-negative patients is not well established. CASE DESCRIPTION: We report a case of a 5-year, durable remission of HHV-8-positive, HIV-negative comorbid multicentric Castleman's disease and Kaposi's sarcoma treated with long-term valganciclovir, following initial rituximab and liposomal doxorubicin...
October 28, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27783090/dual-intravitreal-injections-with-foscarnet-and-ganciclovir-for-ganciclovir-resistant-recurrent-cytomegalovirus-retinitis-in-a-congenitally-infected-infant
#16
Joseph D Boss, Kevin Rosenberg, Rajiv Shah
Resistant strains of cytomegalovirus can be difficult to treat in cases of congenital cytomegalovirus retinitis. The authors describe a case of recurrent bilateral congenital cytomegalovirus retinitis in an immunocompetent newborn with ganciclovir resistance successfully treated uniquely with dual therapy of intravenous ganciclovir and foscarnet and dual intravitreal injections with ganciclovir and foscarnet. [J Pediatr Ophthalmol Strabismus. 2016;53:e58-e60.].
October 22, 2016: Journal of Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/27773488/update-on-infections-with-human-herpesviruses-6a-6b-and-7
#17
H Agut, P Bonnafous, A Gautheret-Dejean
Human herpesviruses 6A, 6B, and 7 (HHV-6A, HHV-6B, HHV-7) are genetically related to cytomegalovirus. They belong to the Roseolovirus genus and to the Betaherpesvirinae subfamily. They infect T cells, monocytes-macrophages, epithelial cells, and central nervous system cells. These viruses are ubiquitous and are responsible for lifelong chronic infections, most often asymptomatic, in the vast majority of the general adult population. HHV-6B is responsible for exanthema subitum, which is a benign disease of infants...
October 20, 2016: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/27772620/cytomegalovirus-and-other-%C3%AE-herpesviruses
#18
REVIEW
Carlos A Q Santos
Cytomegalovirus (CMV), human herpes virus (HHV)-6, and HHV-7 are ubiquitous β-herpesviruses that can cause opportunistic infection and disease in kidney transplant recipients. Active CMV infection and disease are associated with acute allograft failure and death, and HHV-6 and HHV-7 replication are associated with CMV disease. CMV prevention strategies are used commonly after kidney transplantation, and include prophylaxis with antiviral medications and preemptive treatment upon the detection of asymptomatic viral replication in blood...
September 2016: Seminars in Nephrology
https://www.readbyqxmd.com/read/27760756/how-i-treat-resistant-cytomegalovirus-infection-in-hematopoietic-cell-transplantation-recipients
#19
Firas El Chaer, Dimpy P Shah, Roy F Chemaly
Cytomegalovirus (CMV) infection is a significant complication in hematopoietic cell transplantation (HCT) recipients. Four antiviral drugs are used for preventing or treating CMV: ganciclovir, valganciclovir, foscarnet, and cidofovir. With prolonged and repeated use of these drugs, CMV can become resistant to standard therapy, resulting in increased morbidity and mortality, especially in HCT recipients. Antiviral drug resistance should be suspected when CMV viremia (DNAemia or antigenemia) fails to improve or continue to increase after 2 weeks of appropriately dosed and delivered antiviral therapy...
October 19, 2016: Blood
https://www.readbyqxmd.com/read/27756269/acute-multifocal-hemorrhagic-retinal-vasculitis-in-a-child-a-case-report
#20
Malik Y Ghannam, Mohammed Naseemuddin, Peter Weiser, John O Mason
BACKGROUND: Acute Multifocal Hemorrhagic Retinal Vasculitis (AMHRV) is a rare disease with unknown incidence that presents with abrupt onset of visual loss associated with retinal vasculitis, retinal hemorrhage, non-confluent posterior retinal infiltrates, vitreous cellular inflammation and papillitis in, otherwise, healthy adult individuals. The reported treatment options for Acute Multifocal Hemorrhagic Retinal Vasculitis are oral corticosteroids, intravitreal ganciclovir and laser photocoagulation or vitrectomy...
October 18, 2016: BMC Ophthalmology
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