keyword
https://read.qxmd.com/read/38075686/a-genome-wide-association-study-reveals-novel-snp-markers-associated-with-resilience-traits-in-two-mediterranean-dairy-sheep-breeds
#1
JOURNAL ARTICLE
Angeliki Argyriadou, Sofia Michailidou, Sotiria Vouraki, Valentina Tsartsianidou, Alexandros Triantafyllidis, Athanasios Gelasakis, Georgios Banos, Georgios Arsenos
Genetic selection for higher productivity increased dairy sheep susceptibility to diseases and environmental stressors, challenging their health and welfare status and production efficiency. Improving resilience to such stressors can enhance their ability to face these challenges without compromising productivity. Our objective was to estimate genomic heritability and perform genome-wide association studies (GWAS) to detect SNPs and candidate genes associated with three proxy traits for resilience (milk somatic cell count-SCC, lactation persistency-LP, body condition score-BCS) of Chios and Frizarta dairy ewes...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37795536/-idiopathic-minimal-change-nephrotic-syndrome-a-podocyte-mystery-nears-the-end
#2
REVIEW
Sumant S Chugh, Lionel C Clement
The discovery of Zinc Fingers and Homeoboxes (ZHX) transcriptional factors and upregulation of hypo-sialylated Angiopoietin-like 4 (ANGPTL4) in podocytes have been crucial in explaining the cardinal manifestations of human Minimal Change Nephrotic Syndrome (MCNS). Recently uncovered genomic defects upstream of ZHX2 induce a ZHX2 hypomorph state that makes podocytes inherently susceptible to mild cytokine storms resulting from a common cold. In ZHX2 hypomorph podocytes, ZHX proteins are redistributed away from normal transmembrane partners like Aminopeptidase A towards alternative binding partners like IL-4Rα...
October 5, 2023: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/37452012/cooperative-regulation-of-zhx1-and-hnrnpa1-drives-the-cardiac-progenitor-specific-transcriptional-activation-during-cardiomyocyte-differentiation
#3
JOURNAL ARTICLE
Yang Chen, Yukang Wu, Jianguo Li, Kai Chen, Wuchan Wang, Zihui Ye, Ke Feng, Yiwei Yang, Yanxin Xu, Jiuhong Kang, Xudong Guo
The zinc finger proteins (ZNFs) mediated transcriptional regulation is critical for cell fate transition. However, it is still unclear how the ZNFs realize their specific regulatory roles in the stage-specific determination of cardiomyocyte differentiation. Here, we reported that the zinc fingers and homeoboxes 1 (Zhx1) protein, transiently expressed during the cell fate transition from mesoderm to cardiac progenitors, was indispensable for the proper cardiomyocyte differentiation of mouse and human embryonic stem cells...
July 14, 2023: Cell Death Discovery
https://read.qxmd.com/read/37434685/decreased-zinc-fingers-and-homeoboxes-family-expression-was-associated-with-unfavorable-outcomes-and-immune-infiltration-in-lung-adenocarcinoma
#4
JOURNAL ARTICLE
Dan Tao, Jueling Tan, Ningning Zhang, Dingyi Yang, Yong Jiang, Wei Zhou, Ying Wang, Yongzhong Wu
BACKGROUND: The zinc-fingers and homeoboxes (ZHX) family is a group of nuclear homodimeric transcriptional repressors that play an essential role in developing and progressing diverse malignancies. However, the association of ZHX family expression with prognosis and immune infiltration in lung adenocarcinoma (LUAD) is still unclear. The current study aimed to investigate the relationship between ZHX family expression and clinical outcomes and immune infiltration in LUAD patients. METHODS: ZHXs family expression was determined by using the Oncomine database and Cancer Cell Line Encyclopedia (CCLE)...
June 30, 2023: Translational Cancer Research
https://read.qxmd.com/read/36232466/zinc-fingers-and-homeobox-family-in-cancer-a-double-edged-sword
#5
REVIEW
Yonghua Bao, Haifeng Zhang, Zhixue Han, Yongchen Guo, Wancai Yang
The zinc fingers and homeobox (ZHX) family includes ZHX1, ZHX2, and ZHX3, and their proteins have similar unique structures, containing two C2H2-type zinc finger motifs and four or five HOX-like homeodomains. The members of the ZHX family can form homodimers or heterodimers with each other or with a subunit of nuclear factor Y. Previous studies have suggested that ZHXs can function as positive or negative transcriptional regulators. Recent studies have further revealed their biological functions and underlying mechanisms in cancers...
September 22, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/34126417/homeobox-gene-amplification-and-methylation-in-oral-squamous-cell-carcinoma
#6
JOURNAL ARTICLE
Maria Fernanda Setúbal Destro Rodrigues, Flávia Caló Aquino Xavier, Carina Duarte Esteves, Rebeca Barros Nascimento, Juliana Stephan Nobile, Patrícia Severino, Rafael de Cicco, Tatiana Natasha Toporcov, Eloiza Helena Tajara, Fábio Daumas Nunes
OBJECTIVES: Investigate the DNA copy number and the methylation profile of the homeobox genes HOXA5, HOXA7, HOXA9, HOXB5, HOXB13, HOXC12, HOXC13, HOXD10, HOXD11, IRX4 and ZHX1, and correlate them with clinicopathological parameters and overall survival. MATERIAL AND METHODS: DNA from OSCC samples and surgical margins were submitted to DNA amplification by qPCR and to DNA methylation analysis using a DNA Methylation PCR Array System. RESULTS: HOXA5, HOXB5 and HOXD10 were amplified in surgical margins while HOXA9, HOXB13 and IRX4 were amplified in OSCC...
June 8, 2021: Archives of Oral Biology
https://read.qxmd.com/read/32774706/prognostic-value-and-therapeutic-implications-of-zhx-family-member-expression-in-human-gastric-cancer
#7
JOURNAL ARTICLE
Yanjie You, Feihu Bai, Haijun Li, Yuhong Ma, Li Yao, Jinpeng Hu, Yonggang Tian
Despite significant advances in the early diagnosis and effective treatment of gastric cancer, it remains the fourth most common cancer and the second leading cause of cancer-related deaths worldwide. The zinc-fingers and homeoboxes (ZHX) family of transcriptional repressors has been shown to play a role in multiple types of cancer. However, the prognostic significance of ZHX expression in patients with gastric cancer remains unclear. This work studied the association between differential expression of ZHX mRNA and outcomes in patients with gastric cancer using data from the Oncomine, CCLE, Kaplan-Meier-plotter, and cBioPortal databases...
2020: American Journal of Translational Research
https://read.qxmd.com/read/32602607/lncrna-snhg17-promotes-proliferation-migration-and-invasion-of-glioma-cells-by-regulating-the-mir-23b-3p-zhx1-axis
#8
JOURNAL ARTICLE
Beihai Ge, Guocheng Li
BACKGROUND: Long non-coding RNA (lncRNA) small nucleolar RNA host gene 17 (SNHG17) is a carcinogenic lncRNA in diverse cancers. Instead, the expression pattern and mechanisms of SNHG17 in glioma still await more verification. METHODS: Paired glioma samples were enrolled. SNHG17, miR-23b-3p and Zinc-fingers and homeoboxes 1 (ZHX1) mRNA expressions were examined by quantitative real-time polymerase chain reaction (qRT-PCR). SNHG17 shRNA and miR-23b-3p mimics were transfected into LN229 and U251 cell lines to repress SNHG17 and up-regulate miR-23b-3p expression, respectively...
June 30, 2020: Journal of Gene Medicine
https://read.qxmd.com/read/32184618/lncrna-linc01140-inhibits-glioma-cell-migration-and-invasion-via-modulation-of-mir-199a-3p-zhx1-axis
#9
JOURNAL ARTICLE
Yanchao Xin, Wuzhong Zhang, Chongchong Mao, Jianxin Li, Xianzhi Liu, Junbo Zhao, Junfeng Xue, Junqing Li, Yonglu Ren
Purpose: Glioma is an aggressive tumor from the nervous system, which causes more than 70% of primary malignant brain tumors. Considering its severe malignancy, there is an urgent need to investigate more practical markers to understand the pathogenesis of glioma, and potential treatment methods for glioma patients. In the paper, we are focused on examining the roles of LINC01140, miR-199a-3p, and ZHX1 in the progression of gliomas, as well as their inner associations and modulation mechanisms...
2020: OncoTargets and Therapy
https://read.qxmd.com/read/32125369/evolutionary-analysis-of-the-zinc-finger-and-homeoboxes-family-of-proteins-identifies-multiple-conserved-domains-and-a-common-early-chordate-ancestor
#10
JOURNAL ARTICLE
Alexandra N Nail, Jeramiah J Smith, Martha L Peterson, Brett T Spear
The Zinc Fingers and Homeoboxes (Zhx) proteins Zhx1, Zhx2 and Zhx3 comprise a small family of proteins containing two amino-terminal C2-H2 zinc fingers and four or five carboxy-terminal homeodomains. These multiple homeodomains make Zhx proteins unusual because the majority of homeodomain-containing proteins contain a single homeodomain. Studies in cultured cells and mice suggest that Zhx proteins can function as positive or negative transcriptional regulators. Zhx2 regulates numerous hepatic genes and all three Zhx proteins have been implicated in different cancers...
March 3, 2020: Genome Biology and Evolution
https://read.qxmd.com/read/32059999/the-zinc-fingers-and-homeoboxes-2-protein-zhx2-and-its-interacting-proteins-regulate-upstream-pathways-in-podocyte-diseases
#11
JOURNAL ARTICLE
Camille Macé, Maria Del Nogal Avila, Caroline B Marshall, Joubert Kharlyngdoh, Ranjan Das, Eduardo Molina-Jijon, Hector Donoro Blazquez, Suresh Shastry, Elisabeth Soria, Jack Wetzels, Henry Dijkman, Carmen Avila-Casado, Lionel C Clement, Sumant S Chugh
Zinc fingers and homeoboxes (ZHX) proteins are heterodimeric transcriptional factors largely expressed at the cell membrane in podocytes in vivo. We found ZHX2-based heterodimers in podocytes, with ZHX2-ZHX1 predominantly at the cell membrane of the podocyte cell body, and ZHX2-ZHX3 at the slit diaphragm. In addition to changes in overall ZHX2 expression, there was increased podocyte nuclear ZHX3 and ZHX2 in patients with focal segmental glomerulosclerosis, and increased podocyte nuclear ZHX1 in patients with minimal change disease...
November 26, 2019: Kidney International
https://read.qxmd.com/read/31768842/effect-of-mir-27b-5p-on-apoptosis-of-human-vascular-endothelial-cells-induced-by-simulated-microgravity
#12
JOURNAL ARTICLE
Yi-Kai Pan, Cheng-Fei Li, Yuan Gao, Yong-Chun Wang, Xi-Qing Sun
Weightlessness-induced cardiovascular dysfunction can lead to physiological and pathological consequences. It has been shown that spaceflight or simulated microgravity can alter expression profiles of some microRNAs (miRNAs). Here, we attempt to identify the role of miRNAs in human umbilical vein endothelial cells (HUVECs) apoptosis under simulated microgravity. RNA-sequencing and quantitative real-time PCR (qRT-PCR) assays were used to identify differentially expressed miRNAs in HUVECs under simulated microgravity...
November 25, 2019: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/31648104/blocking-lncrna-malat1-mir-199a-zhx1-axis-inhibits-glioblastoma-proliferation-and-progression
#13
JOURNAL ARTICLE
Keman Liao, Yingying Lin, Weizhen Gao, Zhipeng Xiao, Rogelio Medina, Pauline Dmitriev, Jing Cui, Zhengping Zhuang, Xiaochun Zhao, Yongming Qiu, Xiaohua Zhang, Jianwei Ge, Liemei Guo
Zinc fingers and homeoboxes 1 (ZHX1) is a transcription repressor that has been implicated in the tumorigenesis and progression of diverse tumors. The functional role and regulating mechanism of ZHX1 has not been elucidated in glioblastoma (GBM). Previous reports have suggested that a large number of non-coding RNAs play a vital role in glioma initiation and progression. This study aimed to investigate the functional role and co-regulatory mechanisms of the metastasis-associated lung adenocarcinoma transcript-1 (MALAT1)/ microRNA-199a (miR-199a)/ZHX1 axis in GBM...
September 17, 2019: Molecular Therapy. Nucleic Acids
https://read.qxmd.com/read/30787639/attenuated-zhx3-expression-serves-as-a-potential-biomarker-that-predicts-poor-clinical-outcomes-in-breast-cancer-patients
#14
JOURNAL ARTICLE
Yanjie You, Yuhong Ma, Qiang Wang, Zhengcai Ye, Yanhong Deng, Feihu Bai
Background: The ZHX family has recently been in the spotlight as an integrator and an indispensable node in carcinogenesis, whose expression is frequently dysregulated in multiple cancers. The current study provides a novel investigation of the expression profiles of ZHX factors in breast cancer. Materials and methods: The mRNA levels of ZHXs and follow-up periods in breast cancer patients were mined through the Oncomine, Cancer Cell Line Encyclopedia, bc-GenExMiner, cBioPortal and Kaplan-Meier plotter databases...
2019: Cancer Management and Research
https://read.qxmd.com/read/30231238/lncrna-dlg1-as1-promotes-cell-proliferation-by-competitively-binding-with-mir-107-and-up-regulating-zhx1-expression-in-cervical-cancer
#15
JOURNAL ARTICLE
Xiaohui Rui, Yun Xu, Yaqing Huang, Linjuan Ji, Xiping Jiang
BACKGROUND/AIMS: Recent studies have revealed that long non-coding RNAs (lncRNAs) are involved in the occurrence and development of various tumors, thereby attracting increasing attention from researchers. The important biological functions of lncRNAs have been recognized gradually, but their mechanism in cervical cancer remains unclear. METHODS: Differentially expressed lncRNAs in cervical cancer and para-carcinoma tissues were identified by screening using an lncRNA array, and candidate lncRNAs were verified by quantitative real-time PCR...
2018: Cellular Physiology and Biochemistry
https://read.qxmd.com/read/30148600/microwave-assisted-facile-synthesis-of-eu-oh-3-nanoclusters-with-pro-proliferative-activity-mediated-by-mir-199a-3p
#16
JOURNAL ARTICLE
Li Zhang, Wanglai Hu, Yadong Wu, Pengfei Wei, Liang Dong, Zongyao Hao, Song Fan, Yonghong Song, Yang Lu, Chaozhao Liang, Longping Wen
As a pharmaceutical excipient, dextran serves as an efficient ligand for stabilizing some clinically available inorganic nanomaterials such as iron oxide nanocrystals. Herein, dextran-capped nanosized europium(III) hydroxides [Eu(OH)3 ] nanoclusters (NCs) composed of 5 nm Eu(OH)3 nanoparticles have been large-scale synthesized via a microwave-accelerated hydrothermal reaction. The as-synthesized Eu(OH)3 NCs exhibited excellent physiological stability and biocompatibility both in vitro and in vivo and possessed considerable pro-proliferative activities in human umbilical vein endothelial cells (HUVECs)...
September 19, 2018: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/28559996/microrna-199a-3p-inhibits-tumorigenesis-of-hepatocellular-carcinoma-cells-by-targeting-zhx1-puma-signal
#17
JOURNAL ARTICLE
Jinping Guan, Zimin Liu, Menjing Xiao, Fengyun Hao, Chenghong Wang, Yan Chen, Yingying Lu, Jun Liang
BACKGROUND AND OBJECTIVE: MicroRNAs play an important role in cell proliferation, apoptosis, differentiation, and invasion by regulating the expression of various genes. For example, the downregulation of microRNA-199a-3p (miR-199a-3p) that is noted in numerous human malignancies, including hepatocellular carcinoma (HCC), results in a poor prognosis in patients with HCC. This finding suggests that miR-199a-3p overexpression in HCC could provide a new treatment approach. We explored this possibility by examining the effects of miR-199a-3p on the growth and apoptosis of HCC cells in vitro and vivo...
2017: American Journal of Translational Research
https://read.qxmd.com/read/28351300/roles-of-zinc-fingers-and-homeoboxes-1-during-the-proliferation-migration-and-invasion-of-glioblastoma-cells
#18
JOURNAL ARTICLE
Ryuk-Jun Kwon, Myoung-Eun Han, Youn-Jae Kim, Yun Hak Kim, Ji-Young Kim, Liangwen Liu, Woong Heo, Sae-Ock Oh
Zinc-fingers and homeoboxes 1 (ZHX1) is a nuclear transcription repressor and known to be involved in cell differentiation and tumorigenesis. However, the pathophysiological roles of ZHX1 have not been characterized in glioblastoma. We examined ZHX1 expression in glioblastoma patients' tissues and analyzed overall survival of the patients based on expression level of ZHX1. We also examined the effects of ZHX1 on proliferation and motility of glioblastoma cells. In silico analysis and immunohistochemical studies showed that the messenger RNA and protein expressions of ZHX1 were higher in the tissues of glioblastoma patients than in normal brain tissues, and that its overexpression was associated with reduced survival...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://read.qxmd.com/read/28152006/expression-and-prognostic-significance-of-zinc-fingers-and-homeoboxes-family-members-in-renal-cell-carcinoma
#19
JOURNAL ARTICLE
Ryuk-Jun Kwon, Yun Hak Kim, Dae Cheon Jeong, Myoung-Eun Han, Ji-Young Kim, Liangwen Liu, Jin-Sup Jung, Sae-Ock Oh
Zinc fingers and homeoboxes (ZHX) is a transcription repressor family that contains three members; ZHX1, ZHX2, and ZHX3. Although ZHX family members have been associated with the progression of cancer, their values as prognostic factors in cancer patients have been poorly examined. Renal cell carcinoma (RCC) is a highly heterogeneous, aggressive cancer that responds variably to treatment. Thus, prognostic molecular markers are required to evaluate disease progression and to improve the survival. In clear cell RCC (ccRCC), ZHX1 and ZHX3 expression were found to be down-regulated but ZHX2 was up-regulated, and the expressions of ZHX1 and ZHX3 were significantly associated with pathological stage...
2017: PloS One
https://read.qxmd.com/read/28142295/identification-of-a-tumor-suppressor-network-in-t-cell-leukemia
#20
JOURNAL ARTICLE
Stefan Nagel, Claudia Pommerenke, Corinna Meyer, Maren Kaufmann, Roderick A F MacLeod, Hans G Drexler
To identify novel cancer-related genes targeted by copy number alterations, we performed genomic profiling of T-cell acute lymphoblastic leukemia (T-ALL) cell lines. In 3/8, we identified a shared deletion at chromosomal position 2p16.3-p21. Within the minimally deleted region, we recognized several candidate tumor suppressor (TS) genes, including FBXO11 and FOXN2. An additional deletion at chromosome 14q23.2-q32.11 included FOXN3, highlighting this class of FOX genes as potential TS. Quantitative expression analyses of FBXO11, FOXN2, and FOXN3 confirmed reduced transcript levels in the identified cell lines...
September 2017: Leukemia & Lymphoma
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