Maria Fernanda Setúbal Destro Rodrigues, Flávia Caló Aquino Xavier, Carina Duarte Esteves, Rebeca Barros Nascimento, Juliana Stephan Nobile, Patrícia Severino, Rafael de Cicco, Tatiana Natasha Toporcov, Eloiza Helena Tajara, Fábio Daumas Nunes
OBJECTIVES: Investigate the DNA copy number and the methylation profile of the homeobox genes HOXA5, HOXA7, HOXA9, HOXB5, HOXB13, HOXC12, HOXC13, HOXD10, HOXD11, IRX4 and ZHX1, and correlate them with clinicopathological parameters and overall survival. MATERIAL AND METHODS: DNA from OSCC samples and surgical margins were submitted to DNA amplification by qPCR and to DNA methylation analysis using a DNA Methylation PCR Array System. RESULTS: HOXA5, HOXB5 and HOXD10 were amplified in surgical margins while HOXA9, HOXB13 and IRX4 were amplified in OSCC...
June 8, 2021: Archives of Oral Biology