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https://www.readbyqxmd.com/read/29245156/selection-and-targeting-of-epcam-protein-by-ssdna-aptamer
#1
Walhan Alshaer, Nida Ababneh, Mamon Hatmal, Heba Izmirli, Moujab Choukeife, Alaa Shraim, Nour Sharar, Aya Abu-Shiekah, Fadwa Odeh, Abeer Al Bawab, Abdalla Awidi, Said Ismail
Aptamers are molecules that reveal highly complex and refined molecular recognition properties. These molecules are capable of binding with high affinity and selectivity to targets, ranging from small molecules to whole living cells. Several aptamers have been selected for targeting cellular proteins and they have also used in developing therapeutics and diagnostic strategies. Epithelial cell adhesion molecule (EpCAM) is considered as a cancer stem cell (CSC) biomarker and one of the most promising targets for aptamer selection against CSCs...
2017: PloS One
https://www.readbyqxmd.com/read/29212456/helicobacter-induced-gastric-inflammation-alters-the-properties-of-gastric-tissue-stem-progenitor-cells
#2
Wataru Shibata, Soichiro Sue, Sachiko Tsumura, Yasuaki Ishii, Takeshi Sato, Eri Kameta, Makoto Sugimori, Hiroaki Yamada, Hiroaki Kaneko, Tomohiko Sasaki, Tomohiro Ishii, Toshihide Tamura, Masaaki Kondo, Shin Maeda
BACKGROUND: Although Helicobacter-induced gastric inflammation is the major predisposing factor for gastric carcinogenesis, the precise mechanism by which chronic gastritis causes gastric cancer remains unclear. Intestinal and spasmolytic polypeptide-expressing metaplasia (SPEM) is considered as precancerous lesions, changes in epithelial tissue stem/progenitor cells after chronic inflammation has not been clarified yet. In this study, we utilized three-dimensional gastric epithelial cell culture systems that could form organoids, mimicking gastric epithelial layer, and characterized the changes in epithelial cells after chronic Helicobacter felis infection...
December 6, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29212193/microrna-expression-profiling-in-exosomes-derived-from-gastric-cancer-stem-like-cells
#3
Zhan-Peng Sun, An-Qi Li, Wen-Huan Jia, Sen Ye, Grace Van Eps, Jian-Min Yu, Wei-Jun Yang
Cancer stem-like cells (CSCs) have been identified as the initial cell in formation of cancer. Quiescent CSCs can "hide out" from traditional cancer therapy which may produce an initial response but are often unsuccessful in curing patients. Thus, levels of CSC in patients may be used as an indicator to measure the chance of recurrence of cancer after therapy. The goals of our work are to develop specific exosomal miRNA clusters for gastric CSCs that can potentially predict which patients are at high risk for developing gastric cancer (GC) in order to diagnose GC at an early stage...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29178392/slc34a2-regulates-mir-25-gsk3%C3%AE-signaling-pathway-to-affect-tumor-progression-in-gastric-cancer-stem-cell-like-cells
#4
Lanfang Zhang, Xiaohe Guo, Lili Zhang, Fang Yang, Lei Qin, Dezhong Zhang, Yongmei Qin
A novel paradigm in tumor biology suggests that gastric cancer progression is driven by gastric cancer stem cell-like cells (GCSCs), but molecular mechanisms regulating tumorigenic and self-renewal potential of GCSCs are still unclear. Here, we aim to investigate biological function of SLC34A2 in regulating sphere formation and tumorigenicity (both are the hallmark of CSCs) of GCSCs and its underlying mechanisms. Our findings testified that CD44+ cells which were derived from fresh primary gastric cancer samples and cell lines displayed stem cell-like features...
November 27, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29158800/a-bottleneck-in-understanding-metastatic-cancer-stem-cell-of-peritoneal-seeding-from-gastric-cancer-a-null-result-in-brief
#5
Xin-Zu Chen, Xiao-Hai Song, Xiao-Long Chen, Chang-Chun Li, Xian-Ming Mo, Jian-Kun Hu
The capture of peritoneal metastatic cancer stem cell of human gastric cancer (pMCSC-hGC) is important to further understand the mechanism of peritoneal metastasis in gastric cancer patients. Previously, cancer stem cells (CSCs) of gastric and rectal cancers were captured and identified. However, the bottleneck of capturing pMCSC-hGC may be the scarce surgical specimen and limited volume of peritoneal metastatic lesions from gastric cancer. Only 5.2% of patients were diagnosed of unpredictive peritoneal seeding intraoperatively, while none cell sphere were successfully formed through the identical culture approach based on peritoneal metastatic nodules...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29141958/dna-methylation-defines-regional-identity-of-human-intestinal-epithelial-organoids-and-undergoes-dynamic-changes-during-development
#6
Judith Kraiczy, Komal M Nayak, Kate J Howell, Alexander Ross, Jessica Forbester, Camilla Salvestrini, Roxana Mustata, Sally Perkins, Amanda Andersson-Rolf, Esther Leenen, Anke Liebert, Ludovic Vallier, Philip C Rosenstiel, Oliver Stegle, Gordon Dougan, Robert Heuschkel, Bon-Kyoung Koo, Matthias Zilbauer
OBJECTIVE: Human intestinal epithelial organoids (IEOs) are increasingly being recognised as a highly promising translational research tool. However, our understanding of their epigenetic molecular characteristics and behaviour in culture remains limited. DESIGN: We performed genome-wide DNA methylation and transcriptomic profiling of human IEOs derived from paediatric/adult and fetal small and large bowel as well as matching purified human gut epithelium. Furthermore, organoids were subjected to in vitro differentiation and genome editing using CRISPR/Cas9 technology...
November 15, 2017: Gut
https://www.readbyqxmd.com/read/29141593/bidirectional-alteration-of-cav-1-expression-is-associated-with-mitogenic-conversion-of-its-function-in-gastric-tumor-progression
#7
Byung-Kyu Ryu, Min-Goo Lee, Nam-Hoon Kim, Kil Yeon Lee, Shin-Ju Oh, Jung-Rock Moon, Hyo Jong Kim, Sung-Gil Chi
BACKGROUND: Expression of caveolin-1 (Cav-1) is frequently altered in many human cancers and both tumor suppression and promotion functions of Cav-1 have been suggested based on its expression status. However, it remains unanswered how Cav-1 provokes opposite effects in different cancers or different phases of tumor progression. METHODS: To explore the implication of Cav-1 alteration in gastric tumorigenesis, the expression and mutational status of Cav-1 and its effects on tumor cell growth were characterized...
November 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29136685/-heterogeneity-and-stem-cells-of-gastric-cardiac-carcinoma-recent-discoveries
#8
Q Huang, L Li, X S Fan
No abstract text is available yet for this article.
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29133564/fungal-prophylaxis-with-a-gastro-resistant-posaconazole-tablet-for-patients-with-hematological-malignancies-final-result-of-the-posanantes-study
#9
Pierre Peterlin, Cécile Chauvin, Steven Le Gouill, Morgane Pere, Marie Dalichampt, Thierry Guillaume, Alice Garnier, Maxime Paré, Amandine Le Bourgeois, Philippe Moreau, Patrice Chevallier, Guillaume Deslandes, Thomas Gastinne
Posaconazole is an antifungal drug used in both prophylaxis and treatment of invasive fungal infections. Its oral formulation requires therapeutic drug monitoring. To overcome gastric acidity, a gastro-resistant posaconazole tablet has recently been developed. POSANANTES was a prospective non interventional study that aimed to monitor plasma concentration trough level (Cmin) of posaconazole tablets used prophylactically in patients with hematological malignancies. Fifty patients were included. Group A (n= 31) included patients receiving induction chemotherapy for myeloid malignancies and group B (n=19) included patients treated for graft versus host disease after allogeneic hematopoietic stem cells transplantation...
November 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29131081/overexpression-of-the-transmembrane-protein-iqgap3-is-associated-with-poor-survival-of-patients-with-gastric-cancer
#10
Naohide Oue, Yuji Yamamoto, Takashi Oshima, Ryuichi Asai, Akira Ishikawa, Naohiro Uraoka, Naoya Sakamoto, Kazuhiro Sentani, Wataru Yasui
OBJECTIVE: Spheroid colony formation is a useful method of cancer stem cell (CSC) characterization. We previously showed that the IQ motif containing the GTPase-activating protein 3 gene (IQGAP3) is upregulated in spheroid body-forming gastric cancer (GC) cells compared with parental cells. We investigated IQGAP3 expression in GC. METHODS: IQGAP3 protein expression was analyzed by immunohistochemistry in 165 GC cases. RNA interference was used to inhibit IQGAP3 expression in GC cell lines...
November 1, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29123413/overexpression-of-mpc1-inhibits-the-proliferation-migration-invasion-and-stem-cell-like-properties-of-gastric-cancer-cells
#11
Xiang Zhou, Zhu-Juan Xiong, Shuo-Meng Xiao, Jin Zhou, Zhi Ding, Ling-Chao Tang, Xiao-Dong Chen, Rui Xu, Ping Zhao
Invasion and metastasis are major malignant characteristics of human gastric cancer (GC), but the molecular mechanisms underlying the invasion and metastasis of GC cells remain elusive. MPC1, a key factor that controls pyruvate transportation through the inner mitochondrial membrane, was reported to be downregulated and correlated with poor prognosis in several cancers. However, the effects of MPC1 on human GC have not been illustrated. In this study, we investigated the potential role of MPC1 in the proliferation, migration, invasion, and stem cell-like properties of human GC cells and evaluated its prognostic significance for patients with GC...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29121666/sox9-is-a-proliferation-and-stem-cell-factor-in-hepatocellular-carcinoma-and-possess-widespread-prognostic-significance-in-different-cancer-types
#12
Georg Richtig, Ariane Aigelsreiter, Daniela Schwarzenbacher, Anna Lena Ress, Jan Basri Adiprasito, Verena Stiegelbauer, Gerald Hoefler, Silvia Schauer, Tobias Kiesslich, Peter Kornprat, Thomas Winder, Florian Eisner, Armin Gerger, Herbert Stoeger, Rudolf Stauber, Carolin Lackner, Martin Pichler
SOX9 has been previously shown to be involved in hepatocellular carcinoma (HCC) and other types of cancer. However, prognostic studies so far involved rather small cohorts or lack external validation and experimental data. In this study, we firstly determined the histological expression pattern of SOX9 in human HCC by immunohistochemistry (n = 84) and evaluated its prognostic value. External cohorts of publicly available datasets were used to validate its prognostic relevance in HCC (n = 359) and other types of cancer including breast (n = 3951), ovarian (n = 1306), lung (n = 1926) and gastric cancer (n = 876)...
2017: PloS One
https://www.readbyqxmd.com/read/29120019/cellular-protection-mechanisms-that-minimise-accumulation-of-mutations-in-intestinal-tissue
#13
Jacco van Rheenen, Lotte Bruens
The epithelial lining of the intestine is constantly exposed to a hostile environment containing a mixture of gastric acids, consumed harmful substances and microbes. It is widely accepted that the intestine has multiple mechanisms to protect itself against tissue damage. Here, we review three cellular protection mechanisms that protect intestinal tissue against accumulation of somatic mutations: the conveyer belt-like structure, stem cell competition and crypt fusion. We highlight the events that can perturb these cellular protection mechanisms, and their impact on accumulation of new (oncogenic) mutations...
November 9, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29103873/design-synthesis-and-anticancer-properties-of-isocorydine-derivatives
#14
Qian Yan, Ruxia Li, Aiyi Xin, Yin Han, Yanxia Zhang, Junxi Liu, Wenguang Li, Duolong Di
Isocorydine (ICD), an aporphine alkaloid, is widely distributed in nature. Its ability to target side population (SP) cells found in human hepatocellular carcinoma (HCC) makes it and its derivative 8-amino-isocorydine (NICD) promising chemotherapeutic agents for the treatment of HCC. To improve the anticancer activity of isocorydine derivatives, twenty derivatives of NICD were designed and synthesized through chemical structure modifications of the aromatic amino group at C-8. The anti-proliferative activities of all synthesized compounds against human hepatocellular (HepG2), cervical (HeLa), and gastric (MGC-803) cancer cell lines were evaluated using an MTT assay...
October 21, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29098550/enteric-glial-dysfunction-evoked-by-apolipoprotein-e-deficiency-contributes-to-delayed-gastric-emptying
#15
Seiichiro Fukuhara, Tatsuhiro Masaoka, Soraya Nishimura, Masaya Nakamura, Juntaro Matsuzaki, Hitoshi Tsugawa, Sawako Miyoshi, Hideki Mori, Satoshi Kawase, Shinsuke Shibata, Hideyuki Okano, Takanori Kanai, Hidekazu Suzuki
BACKGROUND AND AIM: Diabetes is the main cause of gastroparesis accompanying decreased neuronal nitric oxide synthase (nNOS) in myenteric ganglia of the stomach. Decreased nNOS expression in the stomach also results from defects in apolipoprotein E (ApoE), which is secreted by astrocytes and has neuroprotective effects on the central nervous system. However, the roles of ApoE and enteric glial cells on gastric motility are uncertain. In this study, ApoE and enteric glial cell alterations in gastroparesis were investigated...
December 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29090670/the-epithelial-mesenchymal-transition-pathway-in-two-cases-with-gastric-metastasis-originating-from-breast-carcinoma-one-with-a-metachronous-primary-gastric-cancer
#16
Simona Gurzu, Laura Banias, Tivadar Bara, Istvan Feher, Tivadar Jr Bara, Ioan Jung
BACKGROUND: Metastases to the stomach are extremely rare and the metastatic pathway is not well understood. OBJECTIVE: To present two unusual gastric metastases and a review of the literature regarding the pathway of epithelial mesenchymal transition (EMT) in the metastatic cells. METHOD: The clinicopathological aspects of the two cases were presented in the light of the most recent patents. Data about patents were obtained from the online databases PubMed, World Intellectual Property Organization (WIPO) and Google patents...
November 1, 2017: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/29090473/results-of-a-phase-1-study-of-quizartinib-as-maintenance-therapy-in-subjects-with-acute-myeloid-leukemia-in-remission-following-allogeneic-hematopoietic-stem-cell-transplant
#17
Brenda M Sandmaier, Samer Khaled, Betül Oran, Guy Gammon, Denise Trone, Olga Frankfurt
FLT3-ITD-mutated acute myeloid leukemia (AML) has very high risk of relapse and is associated with poor outcome following allogeneic hematopoietic-cell transplant (allo-HCT). This two-part, phase 1, multicenter, open-label, sequential-group, dose-escalation study aimed to determine dose-limiting toxicities (DLTs), maximum tolerated dose (MTD), and safety/tolerability of quizartinib, a selective and highly potent FLT3 inhibitor, when administered as maintenance therapy after allo-HCT. Thirteen subjects with documented FLT3-ITD-mutated AML in morphological remission following allo-HCT received one of two quizartinib dihydrochloride dose levels (DL): 40 mg/d (DL1; n = 7) and 60 mg/d (DL2; n = 6), administered orally in 28-day cycles for up to 24 cycles...
November 1, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/29084052/personalizing-gastric-cancer-screening-with-predictive-modeling-of-disease-progression-biomarkers
#18
Rachel Walker, Jaime Mejia, Jae K Lee, Jose M Pimiento, Mokenge Malafa, Anna R Giuliano, Domenico Coppola, Heiko Enderling
Gastric cancer (GC) remains the third most common cause of cancer-related death worldwide. Infection with Helicobacter pylori is responsible for over 70% of GC incidence; colonization induces chronic inflammation, which can facilitate progression to intestinal metaplasia, dysplasia, and GC (Correa pathway). Although H. pylori eradication is a necessary first step in GC prevention, some patients continue to progress to advanced stage disease if substantial tissue damage has occurred or inflammation persists...
October 27, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29082766/new-developments-and-clinical-transition-of-hyaluronic-acid-based-nanotherapeutics-for-treatment-of-cancer-reversing-multidrug-resistance-tumour-specific-targetability-and-improved-anticancer-efficacy
#19
Muhammad Hassan Safdar, Zahid Hussain, Mohammed A S Abourehab, Humna Hasan, Sajal Afzal, Hnin Ei Thu
This review aims to overview and critically analyses recent developments in achieving tumour-specific delivery of anticancer agents, maximizing anticancer efficacy, and mitigating tumour progression and off-target effects. Stemming from critical needs to develop target-specific delivery vehicles in cancer therapy, various hyaluronic acid (HA)-conjugated nanomedicines have been fabricated owing to their biocompatibility, safety, tumour-specific targetability of drugs and genes, and proficient interaction with cluster-determinant-44 (CD44) receptors over-expressed on the surface of tumour cells...
October 30, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29057538/enhanced-gastric-cancer-growth-potential-of-mesenchymal-stem-cells-derived-from-gastric-cancer-tissues-educated-by-cd4-t-cells
#20
Rongman Xu, Xiangdong Zhao, Yuanyuan Zhao, Bin Chen, Li Sun, Changgen Xu, Bo Shen, Mei Wang, Wenrong Xu, Wei Zhu
OBJECTIVES: Gastric cancer mesenchymal stem cells (GC-MSCs) can promote the development of tumour growth. The tumour-promoting role of tumour-associated MSCs and T cells has been demonstrated. T cells as the major immune cells may influence and induce a pro-tumour phenotype in MSCs. This study focused on whether CD4(+) T cells can affect GC-MSCs to promote gastric cancer growth. MATERIALS AND METHODS: CD4(+) T cells upregulation of programmed death ligand 1 (PD-L1) expression in GC-MSCs through the phosphorylated signal transducer and activator of transcription (p-STAT3) signalling pathway was confirmed by immunofluorescence, western blotting and RT-PCR...
October 22, 2017: Cell Proliferation
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