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Gastric stem cell

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https://www.readbyqxmd.com/read/27922138/mitomycin-c-treated-human-induced-pluripotent-stem-cells-as-a-safe-delivery-system-of-gold-nanorods-for-targeted-photothermal-therapy-of-gastric-cancer
#1
Meng Yang, Yanlei Liu, Wenxiu Hou, Xiao Zhi, Chunlei Zhang, Xinquan Jiang, Fei Pan, Yuming Yang, Jian Ni, Daxiang Cui
Human-induced pluripotent stem cells (iPS) possess an intrinsic tumor tropism ability. However, iPS cells are impeded in clinical applications of tumor therapy due to the formation of teratomas and their survival in normal organs such as the liver, lungs, spleen and kidneys. Mitomycin C (MMC) can overcome this limitation by suppressing iPS proliferation. Herein, we fabricated a safe delivery system of iPS cells treated with MMC loading with gold nanorods (AuNRs) for the targeted photothermal treatment of gastric cancer...
December 6, 2016: Nanoscale
https://www.readbyqxmd.com/read/27895854/differential-expression-of-aristaless-like-homeobox-4-a-potential-marker-for-gastric-adenocarcinoma
#2
Fariba Ghasemvand, Navid Nezafat, Saeed Hesami Tackallou, Daruosh Momenzadeh, Saeid Rahmanzadeh
AIM: The objective of this experiment was to evaluate the ALX-4 mRNA expression level in different stages of human gastric adenocarcinoma compared to the gastric cancer stem cells (GCSC) and gastric cancer cell line, MKN-45. BACKGROUND: Gastric cancer is the second most common cancer in the world today, leading approximately to 3-10% of all cancer-related deaths. Identification of specific biomarkers could be a crucial approach to improve diagnosis and treatment of this cancer type...
2016: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/27893630/a-comprehensive-in-vitro-comparison-of-preparation-techniques-for-fat-grafting
#3
Libor Streit, Josef Jaros, Veronika Sedlakova, Miroslava Sedlackova, Lubos Drazan, Michal Svoboda, Jakub Pospisil, Tomas Vyska, Jiri Vesely, Ales Hampl
BACKGROUND: Lipomodelling is a technique that uses patient's own fat for tissue regeneration and augmentation. The extent of regenerative effect is reported to be determined by the numbers of adipose tissue-derived stem cells (ASCs) and the viability of cells in processed adipose tissue, which, together with other factors, influence the degree of graft retention. This study addresses whether differences exist in properties of fat graft obtained by three commonly used techniques. METHODS: Adipose tissue harvested from the hypo-gastric regions of 14 patients was processed by decantation, centrifugation, and membrane-based tissue filtration...
November 21, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27891816/dll4-overexpression-increases-gastric-cancer-stem-progenitor-cell-self-renewal-ability-and-correlates-with-poor-clinical-outcome-via-notch-1-signaling-pathway-activation
#4
Zhi-Feng Miao, Hao Xu, Hui-Mian Xu, Zhen-Ning Wang, Ting-Ting Zhao, Yong-Xi Song, Ying-Ying Xu
Gastric cancer is one of the most common malignant diseases, and poses a serious threat to the quality of human life. Gastric cancer stem/progenitor cells (GCSPCs) have critical effects on tumor formation, affecting specific features of self-renewal and differentiation and playing a critical role in metastasis. The Notch-1 pathway is crucially important to GCSPCs and is regulated by DLL4. In this study, DLL4 and Nestin levels were measured in 383 gastric cancer tissue samples by immunohistochemistry, and the clinico-pathological features of patients assessed...
November 28, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27889575/isthmus-time-is-here-runx1-identifies-mucosal-stem-cells-in-the-gastric-corpus
#5
EDITORIAL
James R Goldenring, Jason C Mills
No abstract text is available yet for this article.
November 23, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27878307/hmga2-regulates-epithelial-mesenchymal-transition-and-the-acquisition-of-tumor-stem-cell-properties-through-twist1-in-gastric-cancer
#6
Wei Li, Ziwei Wang, Lang Zha, Dequan Kong, Gang Liao, Hui Li
High expression of high mobility group protein A2 (HMGA2) is correlated with the invasiveness of gastric cancer and is an independent prognostic factor. The reason may be that HMGA2 promotes epithelial-mesenchymal transition (EMT) and the acquisition of tumor stem cell properties, yet the mechanism remains unclear. In this study, immunohistochemistry and western blot analysis revealed that the expression of HMGA2 and Twist-related protein 1 (TWIST1) in gastric carcinoma tissues was higher than that in the peritumoral tissues and that the expression levels of these two proteins were positively correlated...
November 18, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27869179/interleukins-17-and-23-in-patients-with-gastric-neoplasms
#7
Wojciech Błogowski, Anna Madej-Michniewicz, Natalia Marczuk, Barbara Dołęgowska, Teresa Starzyńska
Recently there has been heightened interest in the potential significance of interleukin (IL)-17 and IL-23 in the development/progression of human malignancies. Here, we analyzed the systemic levels of these cytokines in 75 patients with different types of gastric neoplasms (carcinoma, gastrointestinal stromal tumors, neuroendocrine neoplasms, and lymphomas) and 42 healthy volunteers. We found that patients with all types of gastric neoplasms have significantly lower IL-23 levels. However, in comparison to the levels in healthy individuals, IL-17 concentrations were lower only in patients with types of gastric neoplasms other than carcinoma...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27846906/upregulation-of-mir-501-5p-activates-the-wnt-%C3%AE-catenin-signaling-pathway-and-enhances-stem-cell-like-phenotype-in-gastric-cancer
#8
Dongmei Fan, Baoqi Ren, Xiaojun Yang, Jia Liu, Zhengzheng Zhang
BACKGROUND: miRNAs are critical post-transcriptional regulators of gene expression and key mediators of tumourigenesis. miR-501-5p is newly identified to be involved in the tumor progression, but its biological role and mechanism remain largely unknown. This study is aimed to study the role of miR-501-5p in the progression of gastric cancer. METHODS: Real-time PCR analysis was used to determine miR-501-5p expression in gastric cancer cell lines, clinical tissues and 112 clinicopathologically characterized gastric cancer specimens...
November 15, 2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27824145/sulforaphane-improves-chemotherapy-efficacy-by-targeting-cancer-stem-cell-like-properties-via-the-mir-124-il-6r-stat3-axis
#9
Xingxing Wang, Yuan Li, Yi Dai, Qinqiang Liu, Shilong Ning, Jiao Liu, Zhaoxia Shen, Dongmei Zhu, Fei Jiang, Jianping Zhang, Zhong Li
Gastric carcinoma (GC) is the second leading cause of cancer-related mortality worldwide. The efficacy of standard chemotherapy for GC, such as cisplatin (CDDP), is dissatisfactory partly due to the toxic/side-effects. Sulforaphane (SFN), which exhibits effective anti-cancer functions, is a phytochemical converted from cruciferous plants. Our present study aimed to identify whether SFN could enhance the anti-cancer effects of low-dose CDDP and to determine the underlying mechanisms. Herein, co-exposure of SFN and CDDP significantly inhibited the viabilities of gastric cancer cells...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27819668/sall4-promotes-gastric-cancer-progression-through-activating-cd44-expression
#10
X Yuan, X Zhang, W Zhang, W Liang, P Zhang, H Shi, B Zhang, M Shao, Y Yan, H Qian, W Xu
The stem cell factor SALL4 (Sal-like protein 4) plays important roles in the development and progression of cancer. SALL4 is critically involved in tumour growth, metastasis and therapy resistance. However, the underlying mechanisms responsible for the oncogenic roles of SALL4 have not been well characterized. In this study, we demonstrated that SALL4 knockdown by short hairpin RNA greatly inhibited the proliferation, migration and invasion of gastric cancer cells. We further confirmed the inhibitory effects of SALL4 knockdown on gastric cancer cells by using a tetracycline-inducible system...
November 7, 2016: Oncogenesis
https://www.readbyqxmd.com/read/27814583/3d-culture-of-mouse-gastric-stem-cells-using-porous-microcarriers
#11
Razan Alkhatib, Ali Hilal-Alnaqbi, Mariam Naciri, Rasoul Al-Majmaie, Prashanth Saseedharan, Sherif M Karam, Mohamed Al-Rubeai
The lining epithelium of the stomach includes multipotent stem cells which undergo proliferation and migration-associated differentiation. These cells give rise to multiple cell lineages that produce mucus, acid, pepsinogen and various hormones/peptides. A 3D culture for stem cells would facilitate identification of the factors that control proliferation and/or differentiation programs. Here, we report on the use of disk-like ImmobaSil HD silicone-rubber matrix based microcarriers that are permeable to oxygen and reduce the creation of toxic environment within the center of the microcarrierd for culturing the mouse gastric stem (mGS) cells...
January 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/27813686/the-telomerase-activity-of-selenium-induced-human-umbilical-cord-mesenchymal-stem-cells-is-associated-with-different-levels-of-c-myc-and-p53-expression
#12
Leila Hosseinzadeh Anvar, Saeid Hosseini-Asl, Mohammad Mohammadzadeh-Vardin, Mohsen Sagha
Selenium-as a trace element-is nutritionally essential for humans. It prevents cancerous growth by inhibiting the telomerase activity but the mechanism involved in regulation of telomerase activity in normal telomerase-positive cells remains to be elucidated. Here, we find out whether the effect of sodium selenite and selenomethionine on telomerase activity in human umbilical cord-derived mesenchymal stem cells (hUCMSCs) is associated with different levels of c-Myc and p53 expression. The use of different staining methods including ethidium bromide/acridine orange and DAPI in addition to telomeric repeat amplification protocol assay and real-time PCR indicated that different forms of selenium have opposite impacts on c-Myc and p53 expressions in both hUCMSCs and AGS, a gastric adenocarcinoma cell line, as a positive control...
November 4, 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27803115/alterations-in-the-epithelial-stem-cell-compartment-could-contribute-to-permanent-changes-in-the-mucosa-of-patients-with-ulcerative-colitis
#13
Isabella Dotti, Rut Mora-Buch, Elena Ferrer-Picón, Núria Planell, Peter Jung, M Carme Masamunt, Raquel Franco Leal, Javier Martín de Carpi, Josep Llach, Ingrid Ordás, Eduard Batlle, Julián Panés, Azucena Salas
OBJECTIVE: UC is a chronic inflammatory disease of the colonic mucosa. Growing evidence supports a role for epithelial cell defects in driving pathology. Moreover, long-lasting changes in the epithelial barrier have been reported in quiescent UC. Our aim was to investigate whether epithelial cell defects could originate from changes in the epithelial compartment imprinted by the disease. DESIGN: Epithelial organoid cultures (EpOCs) were expanded ex vivo from the intestinal crypts of non-IBD controls and patients with UC...
November 1, 2016: Gut
https://www.readbyqxmd.com/read/27800139/the-effect-of-microrna-375-overexpression-an-inhibitor-of-helicobacter-pylori-induced-carcinogenesis-on-lncrna-sox2ot
#14
Mohammad Shafiee, Seyed Ahmad Aleyasin, Seyed Javad Mowla, Mohammad Vasei, Seyed Amir Yazdanparast
BACKGROUND: Helicobacter pylori is a major human pathogenic bacterium in gastric mucosa. Although the association between gastric cancer and H. pylori has been well-established, the molecular mechanisms underlying H. pylori-induced carcinogenesis are still under investigation. MicroRNAs (miRNAs) are small noncoding RNAs that modulate gene expression at the posttranscriptional level. Recently, studies have revealed that miRNAs are involved in immune response and host cell response to bacteria...
September 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27779706/effect-of-colorectal-cancer-on-the-number-of-normal-stem-cells-circulating-in-peripheral-blood
#15
Wojciech Marlicz, Katarzyna Sielatycka, Karol Serwin, Ewa Kubis, Marta Tkacz, Rafał Głuszko, Andrzej Białek, Teresa Starzyńska, Mariusz Z Ratajczak
Bone marrow (BM) residing stem cells are mobilized from their BM niches into peripheral blood (PB) in several pathological situations including tissue organ injury and systemic inflammation. We recently reported that the number of BM-derived stem cells (SCs) increases in patients with pancreatic and stomach cancer. Accordingly, we observed higher numbers of circulating very small embryonic/epiblast‑like stem cells (VSELs) and mesenchymal stem cells (MSCs) that were associated with the activation of pro-mobilizing complement cascade and an elevated level of sphingosine-1 phosphate (S1P) in PB plasma...
October 18, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27766298/epithelial-regeneration-after-gastric-ulceration-causes-prolonged-cell-type-alterations
#16
Eitaro Aihara, Andrea L Matthis, Rebekah A Karns, Kristen A Engevik, Peihua Jiang, Jiang Wang, Bruce R Yacyshyn, Marshall H Montrose
BACKGROUND & AIMS: The peptic ulcer heals through a complex process, although the ulcer relapse often occurs several years later after healing. Our hypothesis is that even after visual evidence of healing of gastric ulceration, the regenerated epithelium is aberrant for an extended interval, increasing susceptibility of the regenerated epithelium to damage and further diseases. METHODS: Gastric ulcers were induced in mice by serosal topical application of acetic acid...
September 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27759647/clinicopathological-and-prognostic-significance-of-cancer-stem-cell-markers-cd44-and-cd133-in-patients-with-gastric-cancer-a-comprehensive-meta-analysis-with-4729-patients-involved
#17
Li Lu, Menglin Wu, Longhao Sun, Weidong Li, Weihua Fu, Xuening Zhang, Tong Liu
BACKGROUND: In recent years, CD44 and CD133 have been identified as 2 common used cancer stem cell (CSC) markers in gastric cancer. However, the clinicopathological and prognostic value of these markers in gastric cancer remains controversial; moreover, there is lack of comparison of these 2 markers' roles in clinical applications. A systematic review and meta-analysis was conducted to elucidate these markers' clinicopathological features and association with prognosis in patients with gastric cancer...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27751517/combined-effect-of-bone-marrow-derived-mesenchymal-stem-cells-and-nitric-oxide-inducer-on-injured-gastric-mucosa-in-a-rat-model
#18
Laila Rashed, Doaa Mostafa Gharib, Rania Elsayed Hussein, Ola Tork, Azza Abusree
AIM: To study the effect of intravenous injection of bone marrow mesenchymal stem cells (BMMSCs), alone and combined with NO inducer in gastric ulcer healing in a rat model. METHODS: Rats were divided into controls, gastric ulcer, gastric ulcer receiving mesenchymal stem cells (MSCs), gastric ulcer receiving NO inducer (l-Arginine), gastric ulcer receiving MSCs plus NO inducer (l-Arginine) groups. MSCs were given in a dose of (10(6)cells) by intravenous injection...
September 28, 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27748935/proton-pump-inhibitor-pantoprazole-inhibits-the-proliferation-self%C3%A2-renewal-and-chemoresistance-of-gastric-cancer-stem-cells-via-the-emt-%C3%AE-%C3%A2-catenin-pathways
#19
Shuitu Feng, Zhigao Zheng, Lihua Feng, Lihong Yang, Zuhong Chen, Yubiao Lin, Yingqin Gao, Yide Chen
The cancer stem cell (CSC) model suggests that a small subset of cancer cells possess stem cell properties and plays a crucial role in tumor initiation, metastasis and resistance to anticancer therapy. Exploration of the specific therapies targeting at CSCs has been a crucial issue in antitumor research. Gastric cancer (GC) cells often exist in an ischemic microenvironment with acidic conditions in vivo, thus maintenance of cellular pH homeostasis is important for the survival and function of GC cells. Proton pump inhibitors (PPIs) may prevent intracellular proton extrusions which consequently reduce cancer cell survival under acidic conditions...
October 7, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27735991/plgf-knockdown-decreases-tumorigenicity-and-stemness-properties-of-spheroid-body-cells-derived-from-gastric-cancer-cells
#20
Fatemeh Mahmoodi, Hassan Akrami
Placental growth factor (PlGF) a member of the vascular endothelial growth factor family regulates some cell processes such as survival, growth of vascular endothelial cells, invasiveness and also involves in pathological angiogenesis and metastasis in most cancers. Cancer stem cells are believed to be the main reason for the tumor relapse and resistance to therapy. These cells have various characteristics as same as normal tissue-specific adult stem cells, including self-renewability and potent to differentiate into various cell types...
October 13, 2016: Journal of Cellular Biochemistry
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