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https://www.readbyqxmd.com/read/29441735/the-role-of-mmu-mir-155-5p-nf-%C3%AE%C2%BAb-signaling-in-the-education-of-bone-marrow-derived-mesenchymal-stem-cells-by-gastric-cancer-cells
#1
Mei Wang, Fang Yang, Rong Qiu, Mengchu Zhu, Huiling Zhang, Wenrong Xu, Bo Shen, Wei Zhu
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are important precursors of tumor stromal cells. Previously, we have demonstrated that miR-155-5p inhibition directly induced transition of BM-MSCs into gastric cancer-associated MSCs. Whether miR-155-5p is involved in the education of BM-MSCs by gastric cancer cells has not been established. Murine BM-MSCs (mMSCs) were isolated and grown in conditioned medium derived from gastric cancer cell line MFC (MFC-CM). The tumor-promoting phenotype and function of mMSCs were detected by immunofluorescence staining, quantitative reverse transcription-polymerase chain reaction (qRT-PCR), cell colony formation assay, transwell migration, and invasion assays...
February 14, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29435053/rkip-and-peroxiredoxin-2-expression-predicts-the-proliferative-potential-of-gastric-cancer-stem-cells
#2
Shao-Feng Yang, Ran Ma, Li-Li Pan, Jing Cao, Nan Sheng
Gastric cancer is associated with a high mortality rate, with the development of gastric cancer stem cells underlying this. Gastric cancer stem cells are responsible for tumor initiation, progression and recurrence. However, the link between gastric cancer and gastric cancer stem cells remains to be fully understood. Murine models mimic a human microenvironment more accurately than in vitro studies and are useful models for understanding the behavior of different markers. The present study compared the expression of cluster of differentiation 44 (CD44), a stem cell marker, with the expression of other cancer-associated markers, including Raf kinase inhibitor protein (RKIP) and peroxiredoxin 2, in different pathological conditions of gastric cancer development using histological, immunohistological and western blot analyses...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29435040/prostate-stem-cell-antigen-is-expressed-in-normal-and-malignant-human-brain-tissues
#3
Hiroe Ono, Hiromi Sakamoto, Teruhiko Yoshida, Norihisa Saeki
Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein and exhibits an organ-dependent expression pattern in cancer. PSCA is upregulated in prostate cancer and downregulated in gastric cancer. PSCA is expressed in a variety of human organs. Although certain studies previously demonstrated its expression in the mammalian and avian brain, its expression in the human brain has not been thoroughly elucidated. Additionally, it was previously reported that PSCA is weakly expressed in the astrocytes of the normal human brain but aberrantly expressed in glioma, suggesting that PSCA is a promising target of glioma therapy and prostate cancer therapy...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29428221/the-inflammatory-microenvironment-that-promotes-gastrointestinal-cancer-development-and-invasion
#4
REVIEW
Kanae Echizen, Hiroko Oshima, Mizuho Nakayama, Masanobu Oshima
Accumulating evidence has indicated that the inflammatory response is important for tumor promotion. However, the mechanisms underlying the induction of the inflammatory response in cancer tissues and how it promotes tumorigenesis remain poorly understood. We constructed several mouse models that develop inflammation-associated gastric and intestinal tumors and examined the in vivo mechanisms of tumorigenesis. Of note, the activation of cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway and Toll-like receptor (TLR)/MyD88 signaling cooperatively induced the generation of an inflammatory microenvironment, which is required for early-stage tumorigenesis...
February 5, 2018: Advances in Biological Regulation
https://www.readbyqxmd.com/read/29423095/decrease-in-psca-expression-caused-by-helicobacter-pylori-infection-may-promote-progression-to-severe-gastritis
#5
Osamu Toyoshima, Chizu Tanikawa, Ryuta Yamamoto, Hidenobu Watanabe, Hiroharu Yamashita, Kosuke Sakitani, Shuntaro Yoshida, Michiaki Kubo, Keitaro Matsuo, Hidemi Ito, Kazuhiko Koike, Yasuyuki Seto, Koichi Matsuda
SNP rs2294008 in Prostate Stem Cell Antigen (PSCA) and decreased PSCA expression are associated with gastric cancer. The objective of this study is to investigate the role of rs2294008 and PSCA expression in the gastritis-gastric cancer carcinogenic pathway. We conducted a case-control association study of H. pylori-infected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (P = 9.4 × 10-5; odds ratio = 3.88, TT + TC vs CC genotype), but not with H. pylori infection per se nor with the progression from active gastritis to gastric cancer...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29423015/interaction-between-cd133-and-pi3k-p85-promotes-chemoresistance-in-gastric-cancer-cells
#6
Shuzheng Song, Guoqing Pei, Yaqiong Du, Jugang Wu, Xiaochun Ni, Shoulian Wang, Bojian Jiang, Meng Luo, Jiwei Yu
Chemoresistance in gastric cancer is the leading cause of tumor recurrence and poses a substantial therapeutic challenge. The stem cell biomarker CD133 has been implicated in drug resistance of tumor-initiating cells in a number of cancers including gastric cancer. Therefore, we investigated the molecular mechanism of CD133-associated multidrug resistance in gastric cancer cells. Using CD133 overexpressing and knockdown gastric cancer cell lines, we demonstrated that loss of CD133 significantly increased the growth inhibition of chemotherapeutic agents; whereas, overexpression significantly reduced growth inhibition...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29422964/association-of-mast-cell-infiltration-with-gastric-cancer-progression
#7
Bei Zhong, Yu Li, Xiaodong Liu, Dongsheng Wang
The present study aimed to determine the expression of mast cells, C-C motif chemokine ligand 2 (CCL-2) and C-C motif chemokine receptor 2 (CCR2) in gastric cancer tumor tissue; and the association of mast cells with the proliferation, migration, invasion and apoptosis of gastric cancer cells. In addition, whether the stem cell factor (SCF)/c-Kit pathway was associated with the secretion of CCL-2 by gastric cancer cells was explored. Flow cytometry analysis and immunohistochemistry were used to observe the relative number of mast cells, and reverse transcription-quantitative polymerase chain reaction and western blot analysis were utilized to determine the expression of CCL-2 and CCR2 mRNA and protein...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29422082/cbx7-regulates-stem-cell-like-properties-of-gastric-cancer-cells-via-p16-and-akt-nf-%C3%AE%C2%BAb-mir-21-pathways
#8
Su-Jie Ni, Li-Qin Zhao, Xiao-Feng Wang, Zhen-Hua Wu, Rui-Xi Hua, Chun-Hua Wan, Jie-Yun Zhang, Xiao-Wei Zhang, Ming-Zhu Huang, Lu Gan, Hua-Lin Sun, Goberdhan P Dimri, Wei-Jian Guo
BACKGROUND: Chromobox protein homolog 7 (CBX7), a member of the polycomb group (PcG) family of proteins, is involved in the regulation of cell proliferation and cancer progression. PcG family members, such as BMI, Mel-18, and EZH2, are integral constituents of the polycomb repressive complexes (PRCs) and have been known to regulate cancer stem cell (CSC) phenotype. However, the role of other PRCs' constituents such as CBX7 in the regulation of CSC phenotype remains largely elusive. This study was to investigate the role of CBX7 in regulating stem cell-like properties of gastric cancer and the underlying mechanisms...
February 8, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29421658/polyene-phosphatidylcholine-overcomes-oxaliplatin-resistance-in-human-gastric-cancer-bgc823-cells
#9
Hongjun Zhang, Hao Song, Ronghui Yuan, Xianxiang Zhang, Hongsheng Yu, Yuanyuan Zhao, Tao Jiang
Intrinsic or acquired resistance to oxaliplatin (L-OHP) is a major reason of treatment failure in gastric cancer and limits therapeutic success. Here we generated an oxaliplatin resistant gastric cancer cell line, BGC823/L-OHP, to investigate the effect of a hepatoprotective compound, polyene phosphatidylcholine (PPC), on conquest of oxaliplatin resistance. BGC823/L-OHP cells showed less sensitive to L-OHP directed growth inhibition than the parental BGC823 cells. PPC treatment significantly increased anti-proliferative activity of L-OHP on resistant cells and promoted L-OHP triggered apoptosis, indicating that drug resistance was overcome...
February 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29414870/delivery-of-mesenchymal-stem-cells-from-gelatin-alginate-hydrogels-to-stomach-lumen-for-treatment-of-gastroparesis
#10
Binata Joddar, Nishat Tasnim, Vikram Thakur, Alok Kumar, Richard W McCallum, Munmun Chattopadhyay
Gastroparesis (GP) is associated with depletion of interstitial cells of Cajal (ICCs) and enteric neurons, which leads to pyloric dysfunction followed by severe nausea, vomiting and delayed gastric emptying. Regenerating these fundamental structures with mesenchymal stem cell (MSC) therapy would be helpful to restore gastric function in GP. MSCs have been successfully used in animal models of other gastrointestinal (GI) diseases, including colitis. However, no study has been performed with these cells on GP animals...
February 7, 2018: Bioengineering
https://www.readbyqxmd.com/read/29396430/functional-loss-of-p53-cooperates-with-the-in-vivo-microenvironment-to-promote-malignant-progression-of-gastric-cancers
#11
Junko Ohtsuka, Hiroko Oshima, Issei Ezawa, Ryo Abe, Masanobu Oshima, Rieko Ohki
p53 mutations are frequently detected in malignant gastric cancers. However, the molecular mechanisms by which loss of p53 function promotes gastric cancer are not clear. We utilized Gan mice (K19-Wnt1/C2mE), which have functional p53 and develop intestinal-type gastric tumors, to investigate the role of p53 in gastric cancer progression by knocking out p53. We found that gastric epithelial cells acquire tumorigenicity in the subcutis of C57BL/6 mice as a result of Wnt activation, COX-2 activation and p53 deficiency...
February 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29345968/mature-gastric-chief-cells-are-not-required-for-the-development-of-metaplasia
#12
Hiroto Kinoshita, Yoku Hayakawa, Zhengchuan Niu, Mitsuru Konishi, Masahiro Hata, Mayo Tsuboi, Yuki Hayata, Yohko Hikiba, Sozaburo Ihara, Hayato Nakagawa, Yoshihiro Hirata, Timothy C Wang, K Koike
During human gastric carcinogenesis, intestinal metaplasia (IM) is frequently seen in the atrophic stomach. In mice, a distinct type of metaplasia known as spasmolytic polypeptide-expressing metaplasia (SPEM) is found in several inflammatory and genetically engineered models. Given the diversity of long- and short-term models of mouse SPEM, it remains unclear whether all models have a shared or distinct molecular mechanism. The origin of SPEM in mice is currently under debate. It is postulated that stem or progenitor cells acquire genetic alterations that then supply metaplastic cell clones, while the possibility of transdifferentiation or dedifferentiation from mature gastric chief cells has also been suggested...
January 18, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29340033/cxcr4-expressing-mist1-progenitors-in-the-gastric-antrum-contribute-to-gastric-cancer-development
#13
Kosuke Sakitani, Yoku Hayakawa, Huan Deng, Hiroshi Ariyama, Hiroto Kinoshita, Mitsuru Konishi, Satoshi Ono, Nobumi Suzuki, Sozaburo Ihara, Zhengchuan Niu, Woosook Kim, Takayuki Tanaka, Haibo Liu, Xiaowei Chen, Yagnesh Tailor, James G Fox, Stephen F Konieczny, Hiroshi Onodera, Antonia R Sepulveda, Samuel Asfaha, Yoshihiro Hirata, Daniel L Worthley, Kazuhiko Koike, Timothy C Wang
Mist1 was recently shown to identify a discrete population of stem cells within the isthmus of the oxyntic gland within the gastric corpus. Chief cells at the base of the gastric corpus also express Mist1. The relevance of Mist1 expression as a marker of specific cell populations within the antral glands of the distal stomach, however, is unknown. Using Mist1-CreERT mice, we revealed that Mist1+ antral cells, distinct from the Mist1+ population in the corpus, comprise long-lived progenitors that reside within the antral isthmus above Lgr5+ or CCK2R+ cells...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29335012/the-polycomb-group-protein-ezh2-induces-epithelial-mesenchymal-transition-and-pluripotent-phenotype-of-gastric-cancer-cells-by-binding-to-pten-promoter
#14
Lu Gan, Midie Xu, Ruixi Hua, Cong Tan, Jieyun Zhang, Yiwei Gong, Zhenhua Wu, Weiwei Weng, Weiqi Sheng, Weijian Guo
BACKGROUND: The influences of oncogenic Ezh2 on the progression and prognosis of gastric cancer (GC) and the underlying mechanisms are still poorly understood. Here, we aimed at investigating clinicopathological significance of Ezh2 in GC and the mechanisms underlying its function in GC development. METHODS: The expression level of Ezh2 was determined by qRT-PCR, immunoblot, and immunohistochemistry analysis in 156 pairs of GC tissues and adjacent normal gastric mucosa tissues...
January 15, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29333091/in-vitro-and-in-vivo-effects-of-mirna-19b-20a-92a-on-gastric-cancer-stem-cells-and-the-related-mechanism
#15
Qianwen Shao, Jing Xu, Xin Guan, Bing Zhou, Wei Wei, Rong Deng, Dongzhen Li, Xinyu Xu, Haitao Zhu
We aimed to analyze the in vitro and in vivo effects of miRNA-19b/20a/92a on gastric cancer stem cells (GCSCs) and the related mechanism. GCSCs were cultured until adherence and differentiation, and subjected to miRNA microarray analysis to find and to verify miRNA deletion. Cells stably expressing lentivirus carrying miRNA-19b/20a/92a were constructed by transfection. The relationship between miRNA-19b/20a/92a and renewal of GCSCs was studied by the tumor sphere assay, and that between miRNA-19b/20a/92a and their proliferation was explored with MTT and colony formation assays...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29330298/stemness-is-enhanced-in-gastric-cancer-by-a-set-pp2a-e2f1-axis
#16
Shuhei Enjoji, Ryotaro Yabe, Shunya Tsuji, Kazuhiro Yoshimura, Hideyoshi Kawasaki, Masashi Sakurai, Yusuke Sakai, Hiroko Takenouchi, Shigefumi Yoshino, Shoichi Hazama, Hiroaki Nagano, Hiroko Oshima, Masanobu Oshima, Michael P Vitek, Tetsuya Matsuura, Yoshitaka Hippo, Tatsuya Usui, Takashi Ohama, Koichi Sato
Gastric cancer is the fifth most common malignancy and the third leading cause of cancer-related deaths worldwide. Chemotherapies against gastric cancer often fail, with cancer recurrence due potentially to the persistence of cancer stem cells. This unique subpopulation of cells in tumors possesses the ability to self-renew and dedifferentiate. These cancer stem cells are critical for initiation, maintenance, metastasis, and relapse of cancers; however, the molecular mechanisms supporting cancer stemness remain largely unknown...
January 12, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29318852/-effects-of-electroacupuncture-on-ultrastructure-of-interstitial-cells-of-cajal-and-stem-cell-factor-kit-signal-pathway-of-gastric-antrum-in-diabetic-gastroparesis-rats
#17
Cheng-Cheng Zhang, Ya-Ping Lin, Yan Peng, Zeng-Hui Yue, Hai-Jiao Chen, Jian-Wen Yang, Wei-Wei Liu, Li Liu
OBJECTIVE: To observe the effects of electroacupuncture (EA) on gastrointestinal motility and the ultrastructure of interstitial cells of Cajal (ICC) and the expressions of c-kit receptor protein and stem cell factor (SCF) mRNA in diabetic gastroparesis (DGP) rats, so as to explore its mechanism. METHODS: Fifty SD rats were randomly divided into normal, model, acupoint, non-acupoint and metoclopramide groups (n=10 rats/group). DGP model was established by intraperitoneal injection of streptozotocin (STZ, 2%), and raised with high-sugar high-fat diet irregularly...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29310576/correction-to-helicobacter-induced-gastric-inflammation-alters-the-properties-of-gastric-tissue-stem-progenitor-cells
#18
Wataru Shibata, Soichiro Sue, Sachiko Tsumura, Yasuaki Ishii, Takeshi Sato, Eri Kameta, Makoto Sugimori, Hiroaki Yamada, Hiroaki Kaneko, Tomohiko Sasaki, Tomohiro Ishii, Toshihide Tamura, Masaaki Kondo, Shin Maeda
Unfortunately, the original article [1] contained an error incorporated during production. A duplicated version of Table 1 was published in place of Table 2. Table 2 has been corrected in the original article and is also included correctly below.
January 8, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29303514/depletion-of-s100a4-stromal-cells-does-not-prevent-hcc-development-but-reduces-the-stem-cell-like-phenotype-of-the-tumors
#19
Jingjing Jiao, Álvaro González, Heather L Stevenson, Mihai Gagea, Hikaru Sugimoto, Raghu Kalluri, Laura Beretta
There is a pressing need for the development of novel approaches to treat and prevent hepatocellular carcinoma (HCC). The S100 calcium-binding protein S100A4 is associated with poor prognosis and metastasis in several human cancers. In addition, a role for S100A4 in modulating cancer-initiating cells stemness properties was recently proposed in head and neck and gastric cancers. Whether S100A4+ stromal cells contribute to tumor onset remains, however, an unanswered question. To address that question, we generated a new mouse model allowing for the depletion of S100A4+ cells in a mouse model of HCC with stemness properties, by crossing mice with hepatic deletion of phosphatase and tensin homolog (PTEN) with mice expressing viral thymidine kinase under the control of S100A4 promoter...
January 5, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29288758/chemical-findings-and-in-vitro-biological-studies-to-uphold-the-use-of-ficus-exasperata-vahl-leaf-and-stem-bark
#20
Didier G Mouho, Andreia P Oliveira, Charles Guillaume Kodjo, Patrícia Valentão, Angel Gil-Izquierdo, Paula B Andrade, Zana Adama Ouattara, Yves-Alain Bekro, Federico Ferreres
Ficus exasperata Vahl, commonly known as sandpaper, is a terrestrial Afro-tropical tree used in popular medicine. Despite the existence of some works on the biological activities of this species, its chemical composition is still poorly known. The aim of this study was to extend the knowledge on the phytochemistry and biological properties of this species. Aqueous extracts from F. exasperata leaves and stem bark were analysed. Thirty-one phenolic compounds, comprising cinnamoyl derivatives, flavonoid-O-glycosides, flavonoid-mono-C-glycosides, flavonoid-di-C-glycosides and one furanocoumarin, were determined by HPLC-DAD-ESI/MSn and UPLC-ESI-QTOF-MS, 26 of them being reported for the first time in this species...
December 27, 2017: Food and Chemical Toxicology
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