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Gastric stem cell

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https://www.readbyqxmd.com/read/29028095/bcar4-increase-cisplatin-resistance-and-predicted-poor-survival-in-gastric-cancer-patients
#1
L Wang, Q Chunyan, Y Zhou, Q He, Y Ma, Y Ga, X Wang
OBJECTIVE: Gastric cancer is a common malignancy with increasing worldwide incidence, and chemotherapeutic drugs for gastric cancer are not effective. Long non-coding RNA (lncRNA) has been proved to be important in different cancer progression. In this research, we investigated whether lncRNAs have relations with drug resistance in gastric cancer to find new potential targets for therapy, which can increase the survival time of the drug-resistant gastric patient. PATIENTS AND METHODS: qRT-PCR was used to detect the expression of BCAR4 in 113 cases of gastric cancer tissue and adjacent tissue, and the clinical significance was also analyzed...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29016350/a-novel-design-of-ha-coated-nanoparticles-co-encapsulating-plasmid-metase-and-5-fu-shows-enhanced-application-in-targeting-gastric-cancer-stem-cells
#2
Weifeng Yanga, Houting Zhanga, Lin Xin
Nanoparticles (NPs) is recognized as an attractive vehicles for cancer treatment due to their targeting drug release. Gastric cancer is an important death-related disease, and its therapy methods still need improvement. The NPs were prepared using a precipitation method, and were evaluated using transmission electron microscopy (TEM). MTT and Transwell assays were used to determine cell viability and apoptosis. In vivo experiments were performed to validate the effects of NPs on tumor growth. METase/5-Fu co-encaspulated NPs showed highest zeta size and lowest zeta potential than other NPs...
October 26, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28993190/secretome-from-hypoxia-conditioned-adipose-derived-mesenchymal-stem-cells-promotes-the-healing-of-gastric-mucosal-injury-in-a-rodent-model
#3
Xianfeng Xia, Philip Wai Yan Chiu, Ping Kuen Lam, Wai Ching Chin, Enders Kwok Wai Ng, James Yun Wong Lau
Studies have indicated that the definitive engraftment and transdifferentiation potential of stem cells does not seem crucial for its property of tissue repair. Our previous study showed that transplantation of adipose-derived mesenchymal stem cells (ADMSCs) enhanced the healing of sutured gastric perforation. This study aimed to investigate the paracrine role of ADMSCs in the experimental gastric mucosal injury. Normoxia-conditioned medium (Nor CM) and hypoxia (HPO) CM were obtained after culturing ADMSCs in 20% O2 and 5% O2 for 48h...
October 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28975979/gli2-induces-pdgfrb-expression-and-modulates-cancer-stem-cell-properties-of-gastric-cancer
#4
J-X Wang, J-F Zhou, F-K Huang, L Zhang, Q-L He, H-Y Qian, H-L Lai
OBJECTIVE: In this study, we aimed to investigate the downstream effector of GLI2 in gastric cancer (GC) and their regulative effect on cancer stem cell (CSC) properties of GC. MATERIALS AND METHODS: Bioinformatic data mining was performed in TCGA-Stomach Adenocarcinoma (STAD), as well as in Kaplan-Meier plotter. Moderate-differentiated GC cell line SGC-7901 and poor-differentiated GC cell line MKN-45 were used as in-vitro model to investigate the regulative effect of GLI2 on PDGFRB expression...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28970066/foxo1-reduces-tumorsphere-formation-capacity-and-has-crosstalk-with-lgr5-signaling-in-gastric-cancer-cells
#5
Yiseul Choi, Jinju Park, Young San Ko, Younghoon Kim, Jung-Soo Pyo, Bo Gun Jang, Min A Kim, Jae-Seon Lee, Mee Soo Chang, Byung Lan Lee
Gastric cancer (GC) is a major of cause of cancer-related death and is characterized by its heterogeneity and molecular complexity. FOXO1 is a transcription factor that plays a key role in GC growth and metastasis. However, the implication of FOXO1 in GC cell stemness has been elusive. This study, for the first time, demonstrates that FOXO1 regulates GC cell stemness in association with LGR5. FOXO1 expression was significantly lower in GC tumorsphere cells than in adherent GC cells. FOXO1 silencing and overexpression promoted and inhibited the tumorsphere formation capacity of GC cells, respectively...
September 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28964780/gastric-cancer-tissue-derived-mesenchymal-stem-cells-impact-peripheral-blood-mononuclear-cells-via-disruption-of-treg-th17-balance-to-promote-gastric-cancer-progression
#6
Mei Wang, Bin Chen, Xiao-Xian Sun, Xiang-Dong Zhao, Yuan-Yuan Zhao, Li Sun, Chang-Gen Xu, Bo Shen, Zhao-Liang Su, Wen-Rong Xu, Wei Zhu
Gastric cancer tissue-derived mesenchymal stem cells (GC-MSCs) are important resident stromal cells in the tumor microenvironment (TME) and have been shown to play a key role in gastric cancer progression. Whether GC-MSCs exert a tumor-promoting function by affecting anti-tumor immunity is still unclear. In this study, we used GC-MSC conditioned medium (GC-MSC-CM) to pretreat peripheral blood mononuclear cells (PBMCs) from healthy donors. We found that GC-MSC-CM pretreatment markedly reversed the inhibitory effect of PBMCs on gastric cancer growth in vivo, but did not affect functions of PBMCs on gastric cancer cell proliferation, cell cycle and apoptosis in vitro...
September 27, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28960757/lncrna-sox2-ot-is-a-novel-prognostic-biomarker-for-osteosarcoma-patients-and-regulates-osteosarcoma-cells-proliferation-and-motility-through-modulating-sox2
#7
Zhi Wang, Meiyun Tan, Ge Chen, Zhong Li, Xiaobo Lu
Long noncoding RNA (LncRNA) SOX2 overlapping transcript (SOX2-OT) has been shown to serve an oncogenic role in human lung cancer, hepatocellular carcinoma, and gastric cancer. However, the clinical significance and biological function of lncRNA SOX2-OT in osteosarcoma are still unclear. LncRNA SOX2-OT expression was measured in osteosarcoma tissues and cell lines. Loss-of-function and gain-of-function studies were performed to observe the effects of lncRNA SOX2-OT on osteosarcoma cells proliferation, migration, invasion, and expressions of cancer stem cell biomarker...
September 29, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28959362/inhibition-of-hes1-enhances-lapatinib-sensitivity-in-gastric-cancer-sphere-forming-cells
#8
Luchun Li, Yan Li, Lulu Wang, Zhijuan Wu, Huiwen Ma, Jianghe Shao, Dairong Li, Huiqing Yu, Weiqi Nian, Donglin Wang
It has been considered that the neurogenic locus notch homolog protein (Notch) signaling pathway serves an essential role in cellular differentiation, proliferation and apoptosis. However, the function of the Notch signaling pathway in gastric cancer stem cells (GCSCs) and epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) sensitivity remains unclear. The present study aimed to delineate the role of the Notch1 signaling pathway in GCSCs and lapatinib sensitivity. Sphere-forming cells were separated from human gastric cancer MKN45 parental cells...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28952294/prognostic-value-of-cancer-stem-cell-markers-cd44-and-aldh1-2-in-gastric-cancer-cases
#9
Fatma Senel, Tuba Dilay Kökenek Unal, Hatice Karaman, Mevlüde Inanç, Aynur Aytekin
Purpose: To determine expression levels of CD44 and ALDH1/2, known cancer stem cell (CSC) markers, in stomach adenocarcinomas and assess relationships with clinicopathologic parameters and prognosis. Methods: Eighty patients diagnosed with gastric cancer between the years 2011-2015 were included in this study of clinicopathologic characteristics, postoperative prognostic indexes and stem cell marker CD44 and ALDH1/2 expression in paraffin-embedded tumour sections analyzed immunohistochemically. Clinicopathologic parameters were evaluated using the chi-square test and t-test...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28946555/lgr5high-dclk1high-phenotype-is-more-common-in-early-stage-and-intestinal-subtypes-of-gastric-carcinomas
#10
Elham Kalantari, Mohammad Hossein Asadi Lari, Raheleh Roudi, Alireza Korourian, Zahra Madjd
BACKGROUND: Gastric carcinoma is the third most common malignancy and is one of the main causes of cancer deaths worldwide. Cancer stem cells (CSCs) are a subpopulation of tumour cells capable of self-renewal and differentiation, likely responsible for the initiation, recurrence, metastasis and chemo/radio-resistance. OBJECTIVE: This study was conducted to evaluate the expression patterns and clinicopathologic significance of putative CSC markers, Lgr5 and DCLK1, in gastric carcinoma...
September 15, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28943549/extramedullary-gastric-relapse-at-the-time-of-bone-marrow-relapse-of-acute-lymphoblastic-leukemia-after-allogeneic-bone-marrow-transplantation
#11
Kazuhiko Ikeuchi, Noriko Doki, Akinari Takao, Tsunekazu Hishima, Yuta Yamada, Tatsuya Konishi, Akihito Nagata, Toshiaki Takezaki, Satoshi Kaito, Shuhei Kurosawa, Masahiro Sakaguchi, Kaito Harada, Shunichiro Yasuda, Kosuke Yoshioka, Kyoko Watakabe-Inamoto, Aiko Igarashi, Yuho Najima, Hideharu Muto, Takeshi Kobayashi, Kazuhiko Kakihana, Hisashi Sakamaki, Kazuteru Ohashi
Extramedullary relapse (EMR) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is relatively rare. The most commonly reported sites in acute lymphoblastic leukemia (ALL) patients after allo-HSCT are soft tissue and the central nervous system, and the gastrointestinal system is an uncommon site. We herein report a unique case with massive hematemesis resulting from gastrointestinal relapse of ALL after allo-HSCT. Upper gastrointestinal endoscopy showed bleeding from a 1.5-cm submucosal tumorous lesion with central ulceration on the anterior wall of the stomach...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28931726/impaired-insulin-igf-1-is-responsible-for-diabetic-gastroparesis-by-damaging-myenteric-cholinergic-neurons-and-interstitial-cells-of-cajal
#12
Shu Yang, Bo Wu, Haimei Sun, Tingyi Sun, Kai Han, Dandan Li, Fengqing Ji, Guoquan Zhang, Deshan Zhou
Diabetic gastroparesis is a common complication of diabetes mellitus (DM) that is characterized by decreased serum insulin and insulin-like growth factor-1 (IGF-1). Despite the fact that insulin treatment but not glycemic control potently accelerated gastric emptying in type 1 DM patients, the role of insulin/InsR and IGF-1/IGF-1R signaling in diabetic gastroparesis remains incompletely elucidated. In this study, type 1 DM mice were established and treated with insulin or Voglibose for 8 weeks. The gastric emptying was delayed from DM week 4 when the gastric InsR and IGF-1R were declined...
September 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28929461/the-isolation-culture-and-propagation-of-murine-intestinal-enteroids-for-the-study-of-dietary-lipid-metabolism
#13
Diana Li, Hongli Dong, Alison B Kohan
Since the initial report in 2009 by Sato and Clevers, primary enteroids have been of major interest in the fields of stem cell biology and gastrointestinal (GI) tract biology. More recently, we and others have made major inroads into the physiological relevance of these enteroid models and have shown that enteroids derived from the stomach, intestine, or colon recapitulate major functions of these tissues, namely, gastric acid secretion, lipid absorption and lipoprotein secretion, and ion transport. Here, we detail the isolation of stem cells from the small intestine and the culture and propagation of those stem cells into mature three-dimensional enteroids...
September 20, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28904399/semaphorin-3%C3%A2-c-drives-epithelial-to-mesenchymal-transition-invasiveness-and-stem-like-characteristics-in-prostate-cells
#14
Kevin J Tam, Daniel H F Hui, Wilson W Lee, Mingshu Dong, Tabitha Tombe, Ivy Z F Jiao, Shahram Khosravi, Ario Takeuchi, James W Peacock, Larissa Ivanova, Igor Moskalev, Martin E Gleave, Ralph Buttyan, Michael E Cox, Christopher J Ong
Prostate cancer (PCa) is among the most commonly-occurring cancers worldwide and a leader in cancer-related deaths. Local non-invasive PCa is highly treatable but limited treatment options exist for those with locally-advanced and metastatic forms of the disease underscoring the need to identify mechanisms mediating PCa progression. The semaphorins are a large grouping of membrane-associated or secreted signalling proteins whose normal roles reside in embryogenesis and neuronal development. In this context, semaphorins help establish chemotactic gradients and direct cell movement...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28895255/ubr2-enriched-in-p53-mbmmsc-exosome-promoted-gastric-cancer-progression-via-wnt-%C3%AE-catenin-pathway
#15
Jiahui Mao, Zhaofeng Liang, Bin Zhang, Huan Yang, Xia Li, Hailong Fu, Xu Zhang, Yongmin Yan, Wenrong Xu, Hui Qian
The deficiency or mutation of p53 has been known to be linked to several types of cancers. Mesenchymal stem cell (MSC) is an important component in tumor microenvironment and exosomes secreted by MSCs can transfer bioactive molecules including proteins and nucleic acid to another cells in tumor microenvironment to influence the progress of tumor. However, whether the state of p53 in MSCs can impact the bioactive molecule secretion of exosomes to promote cancer progression and the regulatory mechanism remain elusive...
September 12, 2017: Stem Cells
https://www.readbyqxmd.com/read/28893318/icg-001-suppresses-growth-of-gastric-cancer-cells-and-reduces-chemoresistance-of-cancer-stem-cell-like-population
#16
Yi Liu, Hui Chen, Peiming Zheng, Yingxia Zheng, Qin Luo, Guohua Xie, Yanhui Ma, Lisong Shen
BACKGROUND: ICG-001, a small molecule, binds CREB-binding protein (CBP) to disrupt its interaction with β-catenin and inhibits CBP function as a co-activator of Wnt/β-catenin-mediated transcription. Given its ability to inhibit Wnt/β-catenin signaling pathway, ICG-001 has been used in some tumor types to exert its anticarcinogenic effect. Here, we examined ICG-001 and its potential role as a therapeutic in gastric cancer (GC). METHODS: The gastric cancer cell lines SGC-7901, MGC-803, BGC-823 and MKN-45 were used in vitro and in vivo...
September 11, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28891129/gastric-cancer-basic-aspects
#17
REVIEW
Silvia Molina-Castro, Joana Pereira-Marques, Ceu Figueiredo, Jose C Machado, Christine Varon
Gastric cancer is one of the most incident and deadliest malignancies in the world. Gastric cancer is a heterogeneous disease and the end point of a long and multistep process, which results from the stepwise accumulation of numerous (epi)genetic alterations, leading to dysregulation of oncogenic and tumor suppressor pathways. Gastric cancer stem cells have emerged as fundamental players in cancer development and as contributors to gastric cancer heterogeneity. For this special issue, we will report last year's update on the gastric cancer molecular classification, and in particular address the gastric cancer groups who could benefit from immune checkpoint therapy...
September 2017: Helicobacter
https://www.readbyqxmd.com/read/28890117/potential-for-peritoneal-cancer-cell-seeding-in-endoscopic-full-thickness-resection-for-early-gastric-cancer
#18
Osamu Goto, Masayuki Shimoda, Motoki Sasaki, Yoshiyuki Kiguchi, Yutaka Mitsunaga, Teppei Akimoto, Yasutoshi Ochiai, Ai Fujimoto, Tadateru Maehata, Toshihiro Nishizawa, Hiroya Takeuchi, Yuko Kitagawa, Kaori Kameyama, Naohisa Yahagi
BACKGROUND AND AIMS: During endoscopic full-thickness resection (EFTR) for cancers, whether exposure of the lumen to the abdominal cavity during the procedure is acceptable is controversial because of the potential risk of tumor cell seeding. To assess the possibility of transplantation due to contact with tumor cells during the procedure, we prospectively investigated the ability of cancer cells to be detached by touching the tumor surface. METHODS: In 48 patients with a single early gastric cancer resected by endoscopic submucosal dissection, stamp cytology was performed by touching the surface of the specimens to glass slides...
September 7, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28881855/the-role-of-notch-signaling-in-gastric-carcinoma-molecular-pathogenesis-and-novel-therapeutic-targets
#19
REVIEW
Yizheng Yao, Ying Ni, Jiawen Zhang, Hua Wang, Shihe Shao
Notch signaling, an evolutionarily conserved signaling cascade system, is involved in promoting the progression of different types of cancers. Within the past decades, the Notch signaling pathway has increasingly been shown to have a primary role in deciding the fate of cancer cells and cancer stem cells in the stomach. Most components of Notch signaling are strongly expressed at different levels in gastric carcinoma tissue samples and are associated with a considerable number of clinical parameters. Moreover, crosstalk signaling between the Notch pathway and the Wnt, Ras, and NF-κB pathways promotes the process of gastric carcinogenesis...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881583/troy-is-expressed-in-human-stomach-mucosa-and-a-novel-putative-prognostic-marker-of-intestinal-type-gastric-cancer
#20
Franziska Wilhelm, Christine Böger, Sandra Krüger, Hans-Michael Behrens, Christoph Röcken
Epithelial stem cells of gastrointestinal tissues are characterized and controlled by an active Wnt signaling. Recently, the Wnt target gene Troy has been proposed as a neoplastic marker in the murine intestine. In this study, we explored the putative tumor biological significance of Troy in humans by using immunohistochemistry (104 cases), quantitative RT-PCR (50 cases) and cell culture experiments (MKN45, MKN74). In the non-neoplastic gastric mucosa, Troy was expressed by Muc5AC-positive foveolar epithelium, parietal cells, chief cells and cells of the intestinal metaplasia...
August 1, 2017: Oncotarget
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