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Mickael Silva, Miguel P Machado, Diogo N Silva, Mirko Rossi, Jacob Moran-Gilad, Sergio Santos, Mario Ramirez, João André Carriço
Gene-by-gene approaches are becoming increasingly popular in bacterial genomic epidemiology and outbreak detection. However, there is a lack of open-source scalable software for schema definition and allele calling for these methodologies. The chewBBACA suite was designed to assist users in the creation and evaluation of novel whole-genome or core-genome gene-by-gene typing schemas and subsequent allele calling in bacterial strains of interest. chewBBACA performs the schema creation and allele calls on complete or draft genomes resulting from de novo assemblers...
March 15, 2018: Microbial Genomics
Niko Flink, Kirsi Honkalampi, Soili M Lehto, Virpi Leppänen, Heimo Viinamäki, Sari Lindeman
Borderline personality disorder (BPD) and chronic depression (CD) are common and challenging mental disorders. Maladaptive cognitive schemas have been proposed to increase vulnerability to both disorders. In order to elucidate the role of maladaptive cognitive schemas in BPD and CD, this study compared psychiatric outpatients with BPD (N = 30) and CD (N = 30) in terms of early maladaptive schemas (EMSs). The groups were compared using the Young Schema Questionnaire short form-extended (YSQ-S2-extended) and the 15D health status questionnaire...
March 14, 2018: Clinical Psychology & Psychotherapy
Lara Kujtan, Arif Hussain, Janakiraman Subramanian, Ashiq Masood
PURPOSE OF REVIEW: Recent advances in next-generation sequencing have allowed for detailed molecular analysis of urothelial carcinomas, with potentially significant clinical implications for personalized treatment. Our objective in this review is to highlight studies from the past year that have furthered the understanding of urothelial cancer genomics. RECENT FINDINGS: Recent studies by The Cancer Genome Atlas consortium further characterized urothelial carcinomas via molecular subtyping, and a schema was proposed to match each subtype with potential therapeutic implications...
March 13, 2018: Current Opinion in Oncology
Xin-Qiang Wang, Jun-Cheng Zhu, Lu Liu, Xiang-Yu Chen, Jun-Yu Huo
Pre-service teachers with different professional identity may actively construct different subjective profession-related events based on the same objective profession-related events. To explore the priming effect among pre-service teachers with different professional identity, this study examined the effect of positive, negative, or neutral priming sentences in an individualized narration of profession-related events through a priming paradigm. Forty-two female volunteers were asked to complete positive, negative, and neutral priming sentences describing profession-related events...
2018: Frontiers in Psychology
Peng Wu, Jia-Li Liu, Shi-Mei Pei, Chang-Peng Wu, Kai Yang, Shu-Peng Wang, Song Wu
BACKGROUND: Renal cell carcinoma (RCC) account for over 80% of renal malignancies. The most common type of RCC can be classified into three subtypes including clear cell, papillary and chromophobe. ccRCC (the Clear Cell Renal Cell Carcinoma) is the most frequent form and shows variations in genetics and behavior. To improve accuracy and personalized care and increase the cure rate of cancer, molecular typing for individuals is necessary. METHODS: We adopted the genome, transcriptome and methylation HMK450 data of ccRCC in The Cancer Genome Atlas Network in this research...
March 13, 2018: BMC Cancer
An Ohigashi, Salim Ahmed, Arfan R Afzal, Naoko Shigeta, Helen Tam-Tham, Hideyuki Kanda, Yoshihiro Ishikawa, Tanvir C Turin
INTRODUCTION Japan is a developed country with high use of Internet and online platforms for health information. 'Yahoo! Answer Japan' is the most commonly used question-and-answer service in Japan. AIM To explore the information users seek regarding breast cancer from the 'Yahoo! Answer Japan' web portal. METHODS The 'Yahoo! Answer Japan' portal was searched for the key word 'breast cancer' and all questions searched for the period of 1 January to 31 December 2014 were obtained. The selected questions related to human breast cancer and were not advertisements or promotional material...
June 2017: Journal of Primary Health Care
Mark S Salzer
Community inclusion refers to equal opportunities for people to participate in the community and willingness to welcome and active community attitude. The opportunity to participate in the community is both a medical necessity and a rights issue. This concept provides a novel theoretical framework for the advancement of mental health policies, programs, and global practices that enable the development of the well-being and health of people with mental disorders. Eleven fundamentals for promoting community inclusion of individuals with serious mental illnesses that are supported by key conceptual, theoretical, and research evidence...
September 2017: Vertex: Revista Argentina de Psiquiatriá
Ryan C Fortenberry, Carlie M Novak, Joshua P Layfield, Eduard Matito, Timothy J Lee
Truncated, correlated, wave function methods either produce imaginary frequencies (in the extreme case) or non-physically low frequencies in out-of-plane motions for carbon and adjacent atoms when the carbon atoms engage in π bonding. Cyclopropenylidene is viewed as the simplest aromatic hydrocarbon, and the present as well as previous theoretical studies have shown that this simple molecule exhibits this behavior in the two out-of-plane bends (OPBs). This non-physical behavior has been treated by removing nearly linear dependent basis functions according to eigenvalues of the overlap matrix, by employing basis sets where the spd space saturation is balanced with higher angular momentum functions, by including basis set superposition/incompleteness error (BSSE/BSIE) corrections, or by combining standard correlation methods with explicitly-correlated methods to produce hybrid potential surfaces...
March 9, 2018: Journal of Chemical Theory and Computation
Danya E Keene, Ann Sarnak, Caitlin Coyle
Background and Objectives: Reverse mortgages are loans that allow older homeowners to borrow from their home equity with no repayment due until the borrower dies or moves out of the home. We currently know very little about how homeowners evaluate and experience reverse mortgages as solutions to their financial and housing needs in later life. Furthermore, despite an increasingly diverse population of reverse mortgage borrowers, we know little about how social inequalities may contribute to reverse mortgage decisions and their outcomes...
March 7, 2018: Gerontologist
Johanna Sundag, Christine Zens, Leonie Ascone, Susanne Thome, Tania M Lincoln
BACKGROUND: According to Young's schema theory, Early Maladaptive Schemas (EMSs) arise due to the violation of core emotional needs during childhood. It seems likely that parents have difficulties in satisfying their children's emotional needs if they have high levels of EMSs themselves. AIMS: This study investigated whether the extent of EMSs in parents is associated with the extent of EMSs in their offspring. Moreover, we tested for two putative mechanisms that account for this association: parental coping styles and parenting behaviour...
March 7, 2018: Behavioural and Cognitive Psychotherapy
Mayank Goyal, Bijoy K Menon, Alexis T Wilson, Mohammed A Almekhlafi, Ryan McTaggart, Mahesh Jayaraman, Andrew M Demchuk, Michael D Hill
Background and purpose Ischemic stroke patients must be transferred to comprehensive stroke centers for endovascular treatment, but this transfer can be interpreted post hoc as "futile" if patients do not ultimately undergo the procedure or have a poor outcome. We posit that transfer decisions must instead be evaluated in terms of appropriateness at the time of decision-making. Methods We propose a classification schema for Appropriateness of Transfer for Endovascular Thrombectomy based on patient, logistic, and center characteristics...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
Katarzyna Sobczuk, Anna Sobczuk
Endometrial hyperplasia (EH) is a pathological condition characterised by hyperplastic changes in endometrial glandular and stromal structures lining the uterine cavity. Endometrial hyperplasia, particularly with atypia, is a significant clinical concern because it can be a precursor of endometrial cancer. Accurate diagnosis of precancerous lesions of the endometrium and exclusion of coexisting endometrial carcinomas are absolutely required for the optimal management of patients. The classification of endometrial hyperplasia has had numerous terminology...
September 2017: Przeglad Menopauzalny, Menopause Review
Deanna L Reising, Douglas E Carr, Sally Gindling, Roxie Barnes, Derrick Garletts, Zulfukar Ozdogan
The purpose of this study was to determine whether student performance in a simulation varied according to which grading method was used: pass/fail versus numerical grading with calculation into a course grade. Results showed that student performances were not significantly different when the pass/fail graded group was compared to the numerically graded group, even though students knew which grading schema would be used in their evaluation. The study challenges the opinion that students perform better when they know that they will be numerically graded in simulation...
March 2, 2018: Nursing Education Perspectives
Ana Deligiannis
This article explores how the body and imagination operate as pathways of knowledge through the use of Movement as Active Imagination in clinical practice. This method activates the transcendent function, thus encouraging new therapeutic responses. A philosophical perspective (Spinoza, Nietzsche, Merleau-Ponty) and some concepts from neuroscience (embodied cognition, somatic markers, image schema, mirror neurons, neuronal plasticity) will accompany us throughout this work, illustrated with a clinical vignette...
April 2018: Journal of Analytical Psychology
Ann H Kim, Gener Augustin, Andrew Shevitz, Hannah Kim, Michael R Trivonovich, Alexis R Powell, Norman Kumins, Robert Tarr, Vikram S Kashyap
The decision to intervene for internal carotid stenosis often depends on the degree of stenosis seen on duplex ultrasound (US). The aim of this study is to compare the diagnostic accuracy of two criteria: modified University of Washington (UW) and 2003 Carotid Consensus Panel (CCP). All patients undergoing US in an accredited (IAC) vascular laboratory from January 2010 to June 2015 were reviewed ( n=18,772 US exams). Patients receiving a neck computed tomography angiography (CTA) within 6 months of the US were included in the study ( n=254)...
March 1, 2018: Vascular Medicine
Annika Reinersmann, Thomas Lücke
Our body is both, the object experiencing the world and the subject of our self- experience. As an object, the body provides sensory information via the bodily surface, which is processed and integrated into a coherent representation of the body, the body schema. This representation is considered to form a crucial structure underlying bodily self-identification. The process of integrating multimodal information into a coherent body representation has received extensive research interest with the aim to further clarify its neuronal correlates and functioning in health and disease...
March 2, 2018: Fortschritte der Neurologie-Psychiatrie
Tahlita C M Zuiverloon, Kim E M van Kessel, Trinity J Bivalacqua, Joost L Boormans, Thorsten H Ecke, Petros D Grivas, Anne E Kiltie, Fredrik Liedberg, Andrea Necchi, Bas W van Rhijn, Florian Roghmann, Marta Sanchez-Carbayo, Bernd J Schmitz-Dräger, Felix Wezel, Ashish M Kamat
RATIONALE: Several guidelines exist that address treatment of patients with nonmetastatic muscle-invasive bladder cancer (MIBC). However, most only briefly mention follow-up strategies for patients and hence the treating physician is often left to infer on what the preferred follow-up schema would be for an individual patient. Herein, we aim to synthesize recommendations for follow-up of patients with MIBC for easy reference. METHODS: A multidisciplinary MIBC expert panel from the International Bladder Cancer Network was assembled to critically assess currently available major guidelines on surveillance of MIBC patients...
February 26, 2018: Urologic Oncology
Y X Sun, Z C Pei, S Y Zhan
Objective: Chronic obstructive pulmonary disease, asthma, interstitial lung disease and pulmonary thromboembolism are the most common and severe respiratory diseases, which seriously jeopardizing the health of the Chinese citizens. Large-scale prospective cohort studies are needed to explore the relationships between potential risk factors and respiratory disease outcomes and to observe disease prognoses through long-term follow-ups. We aimed to develop a common data model (CDM) for cohort studies on respiratory diseases, in order to harmonize and facilitate the exchange, pooling, sharing, and storing of data from multiple sources to serve the purpose of reusing or uniforming those follow-up data appeared in the cohorts...
February 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Bo Bach, Joost Hutsebaut
This study examined the utility of the Level of Personality Functioning Scale-Brief Form 2.0 (LPFS-BF 2.0) in measuring features corresponding to self-other impairment of personality functioning as defined in the new general diagnostic guidelines for Personality Disorder in DSM-5 Section III and ICD-11. A mixed clinical sample (N = 228) composed of 121 psychiatric outpatients and 107 incarcerated addicts was administered the LPFS-BF 2.0, World Health Organization Wellbeing Index (WHO-5), Symptom Checklist-90-Revised (SCL-90-R), Personality Inventory for DSM-5 (PID-5), and the Schema Mode Inventory (SMI)...
March 1, 2018: Journal of Personality Assessment
Somin Wadhwa, Aishwarya Gupta, Shubham Dokania, Rakesh Kanji, Ganesh Bagler
Prediction of adverse drug reactions is an important problem in drug discovery endeavors which can be addressed with data-driven strategies. SIDER is one of the most reliable and frequently used datasets for identification of key features as well as building machine learning models for side effects prediction. The inherently unbalanced nature of this data presents with a difficult multi-label multi-class problem towards prediction of drug side effects. We highlight the intrinsic issue with SIDER data and methodological flaws in relying on performance measures such as AUC while attempting to predict side effects...
2018: PloS One
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