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https://www.readbyqxmd.com/read/28329873/-incentive-for-regional-risk-selection-in-the-german-risk-structure-compensation-scheme
#1
Danny Wende
The introduction of the new law GKV-FQWG strengthens the competition between statutory health insurance. If incentives for risk selection exist, they may force a battle for cheap customers. This study aims to document and discuss incentives for regional risk selection in the German risk structure compensation scheme. Identify regional autocorrelation with Moran's l on financial parameters of the risk structure compensation schema. Incentives for regional risk selection do indeed exist. The risk structure compensation schema reduces 91% of the effect and helps to reduce risk selection...
March 22, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28328252/liberal-entity-extraction-rapid-construction-of-fine-grained-entity-typing-systems
#2
Lifu Huang, Jonathan May, Xiaoman Pan, Heng Ji, Xiang Ren, Jiawei Han, Lin Zhao, James A Hendler
The ability of automatically recognizing and typing entities in natural language without prior knowledge (e.g., predefined entity types) is a major challenge in processing such data. Most existing entity typing systems are limited to certain domains, genres, and languages. In this article, we propose a novel unsupervised entity-typing framework by combining symbolic and distributional semantics. We start from learning three types of representations for each entity mention: general semantic representation, specific context representation, and knowledge representation based on knowledge bases...
March 2017: Big Data
https://www.readbyqxmd.com/read/28327682/hopelessness-and-suicidal-ideation-among-patients-with-depression-and-neurotic-disorders-attending-a-tertiary-care-centre-at-eastern-nepal
#3
R Pokharel, S Lama, B R Adhikari
BACKGROUND: Hopelessness is thought to result from a negative appraisal system and interacts with, and worsens, appraisals of defeat and trap which in turn interact with suicide schema and lead to suicidal behaviour. This study was intended to assess hopelessness and suicidal ideation among patients with depression and neurotic disorders at tertiary care centre of eastern Nepal. METHODS: A cross sectional design included 70 respondents by purposive sampling technique...
September 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28327221/there-is-more-to-memory-than-inaccuracy-and-distortion
#4
Brady Wagoner
Exaggerated claims about inaccuracy and downplaying veracity can also be found in research on memory. This commentary on Jussim's 2012 book analyzes these developments in connection with schema and the misinformation effect's purported role in memory distortion. It concludes by looking back to the locus classicus of memory distortion (viz. Bartlett 1932), which in fact provides a more nuanced account of inaccuracy.
January 2017: Behavioral and Brain Sciences
https://www.readbyqxmd.com/read/28326963/the-stillbirth-classification-system-for-the-safe-passage-study
#5
Theonia K Boyd, Colleen A Wright, Hein J Odendaal, Amy J Elliott, Mary Ann Sens, Rebecca D Folkerth, Drucilla J Roberts, Hannah C Kinney
Objective Describe the classification system for assigning the cause of stillbirth in the Safe Passage Study, an international, multi-institutional, prospective analysis conducted by the NIAAA/NICHD-funded Prenatal Alcohol in SIDS and Stillbirth (PASS) Research Network. The study mission is to determine the role of prenatal alcohol and/or cigarette smoke exposure in adverse pregnancy outcomes, including stillbirth, in a high-risk cohort of 12,000 maternal/fetal dyads. Methods The PASS Network classification system is based upon 5 "sites of origin" for cause of stillbirth, further subdivided into mechanism subcategories; both are employed to assign an ultimate cause of death...
March 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28325605/user-recommendation-in-healthcare-social-media-by-assessing-user-similarity-in-heterogeneous-network
#6
Ling Jiang, Christopher C Yang
OBJECTIVE: The rapid growth of online health social websites has captured a vast amount of healthcare information and made the information easy to access for health consumers. E-patients often use these social websites for informational and emotional support. However, health consumers could be easily overwhelmed by the overloaded information. Healthcare information searching can be very difficult for consumers, not to mention most of them are not skilled information searcher. In this work, we investigate the approaches for measuring user similarity in online health social websites...
March 18, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28323113/longitudinal-analysis-of-discussion-topics-in-an-online-breast-cancer-community-using-convolutional-neural-networks
#7
Shaodian Zhang, Edouard Grave, Elizabeth Sklar, Noémie Elhadad
Identifying topics of discussions in online health communities (OHC) is critical to various information extraction applications, but can be difficult because topics of OHC content are usually heterogeneous and domain-dependent. In this paper, we provide a multi-class schema, an annotated dataset, and supervised classifiers based on convolutional neural network (CNN) and other models for the task of classifying discussion topics. We apply the CNN classifier to the most popular breast cancer online community, and carry out cross-sectional and longitudinal analyses to show topic distributions and topic dynamics throughout members' participation...
March 18, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28319789/group-schema-therapy-for-personality-disorders-a-pilot-study-for-implementation-in-acute-psychiatric-in-patient-settings
#8
Igor Nenadić, Sina Lamberth, Neele Reiss
Group schema therapy (GST) has been proposed as a novel long-term treatment programme for borderline and cluster C personality disorders. We implemented a short-term GST programme (12-15 sessions, based on the manual by Farrell and Shaw (2012), including both cognitive / behavioural and experiential interventions for in-patients (n=9) with either borderline or cluster C personality disorders (and axis I co-morbidities) treated in a (sub)acute psychiatric in-patient setting. We evaluated pre- and post-treatment self-report of maladaptive and adaptive schema modes (using the SMI) and early maladaptive schemas (YSQ-3), as well as overall symptom severity (brief symptom check list, BSCL-53-S), patient satisfaction (ZUF-8) and group climate and coherence (GCQ-S)...
February 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28316582/what-we-do-and-do-not-know-about-teaching-medical-image-interpretation
#9
Ellen M Kok, Koos van Geel, Jeroen J G van Merriënboer, Simon G F Robben
Educators in medical image interpretation have difficulty finding scientific evidence as to how they should design their instruction. We review and comment on 81 papers that investigated instructional design in medical image interpretation. We distinguish between studies that evaluated complete offline courses and curricula, studies that evaluated e-learning modules, and studies that evaluated specific educational interventions. Twenty-three percent of all studies evaluated the implementation of complete courses or curricula, and 44% of the studies evaluated the implementation of e-learning modules...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28314689/dna-methylation-based-classification-and-grading-system-for-meningioma-a-multicentre-retrospective-analysis
#10
Felix Sahm, Daniel Schrimpf, Damian Stichel, David T W Jones, Thomas Hielscher, Sebastian Schefzyk, Konstantin Okonechnikov, Christian Koelsche, David E Reuss, David Capper, Dominik Sturm, Hans-Georg Wirsching, Anna Sophie Berghoff, Peter Baumgarten, Annekathrin Kratz, Kristin Huang, Annika K Wefers, Volker Hovestadt, Martin Sill, Hayley P Ellis, Kathreena M Kurian, Ali Fuat Okuducu, Christine Jungk, Katharina Drueschler, Matthias Schick, Melanie Bewerunge-Hudler, Christian Mawrin, Marcel Seiz-Rosenhagen, Ralf Ketter, Matthias Simon, Manfred Westphal, Katrin Lamszus, Albert Becker, Arend Koch, Jens Schittenhelm, Elisabeth J Rushing, V Peter Collins, Stefanie Brehmer, Lukas Chavez, Michael Platten, Daniel Hänggi, Andreas Unterberg, Werner Paulus, Wolfgang Wick, Stefan M Pfister, Michel Mittelbronn, Matthias Preusser, Christel Herold-Mende, Michael Weller, Andreas von Deimling
BACKGROUND: The WHO classification of brain tumours describes 15 subtypes of meningioma. Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III. Grading is based solely on histology, with an absence of molecular markers. Although the existing classification and grading approach is of prognostic value, it harbours shortcomings such as ill-defined parameters for subtypes and grading criteria prone to arbitrary judgment. In this study, we aimed for a comprehensive characterisation of the entire molecular genetic landscape of meningioma to identify biologically and clinically relevant subgroups...
March 14, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28306546/substitute-ct-generation-from-a-single-ultra-short-time-echo-mri-sequence-preliminary-study
#11
Soumya Ghose, Jason A Dowling, Robba Rai, Gary P Liney
In MR guided radiation therapy planning both MR and CT images for a patient are acquired and co-registered to obtain a tissue specific HU map. Generation of the HU map directly from the MRI would eliminate the CT acquisition and may improve radiation therapy planning. In this preliminary study of substitute CT (sCT) generation, two porcine leg phantoms were scanned using a 3D ultrashort echo time (PETRA) sequence and co-registered to corresponding CT images to build tissue specific regression models. The model was created from one co-registered CT-PETRA pair to generate the sCT for the other PETRA image...
March 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28303093/understanding-and-self-organization
#12
Natika W Newton
How do we manage to understand a completely novel state of affairs, such as the sudden effects of an unexpected earthquake, or the arrival of a total stranger instead of the sister we were waiting for? In each case, for a moment we might be stunned, but we are able quite quickly to fit these events into our overall framework for understanding the world. However, terrified and despairing we feel, we know what earthquakes are and this event fits that schema; in the case of the stranger we know that this kind of thing happens, and that we must ask the stranger "Who are you, and where is my sister?" This paper asks about the mechanisms by which we rapidly achieve an understanding of our world, both the unexpected changes we may experience, and the ongoing comfortable familiarity we normally have with our surroundings...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28299607/comprehensive-4-stage-categorization-of-bicuspid-aortic-valve-leaflet-morphology-by-cardiac-mri-in-386-patients
#13
I G Murphy, J Collins, A Powell, M Markl, P McCarthy, S C Malaisrie, J C Carr, A J Barker
Bicuspid aortic valve (BAV) disease is heterogeneous and related to valve dysfunction and aortopathy. Appropriate follow up and surveillance of patients with BAV may depend on correct phenotypic categorization. There are multiple classification schemes, however a need exists to comprehensively capture commissure fusion, leaflet asymmetry, and valve orifice orientation. Our aim was to develop a BAV classification scheme for use at MRI to ascertain the frequency of different phenotypes and the consistency of BAV classification...
March 15, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28296973/quantitative-analysis-of-disfluency-in-children-with-autism-spectrum-disorder-or-language-impairment
#14
Heather MacFarlane, Kyle Gorman, Rosemary Ingham, Alison Presmanes Hill, Katina Papadakis, Géza Kiss, Jan van Santen
Deficits in social communication, particularly pragmatic language, are characteristic of individuals with autism spectrum disorder (ASD). Speech disfluencies may serve pragmatic functions such as cueing speaking problems. Previous studies have found that speakers with ASD differ from typically developing (TD) speakers in the types and patterns of disfluencies they produce, but fail to provide sufficiently detailed characterizations of the methods used to categorize and quantify disfluency, making cross-study comparison difficult...
2017: PloS One
https://www.readbyqxmd.com/read/28295450/efficacy-and-safety-of-testosterone-replacement-gel-for-treating-hypogonadism-in-men-phase-iii-open-label-studies
#15
L Belkoff, G Brock, D Carrara, A Neijber, M Ando, J Mitchel
Efficacy and safety of testosterone gel 2% (TG) were evaluated in two phase 3, open-labelled, single-arm, multicentre studies (000023 and extension study 000077). Hypogonadal men having serum testosterone levels <300 ng/dl at two consecutive measurements were included. Study duration was 9 months (000023: 3 months; 000077: 6 months). Starting dose of TG (46 mg) was applied on upper arm/shoulder. The primary endpoint (000023) was responder rate (subjects with average 24-hour serum testosterone concentration 300-1050 ng/dl on Day 90)...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28285082/response-assessment-in-myeloma-practical-manual-on-consistent-reporting-in-an-era-of-dramatic-therapeutic-advances
#16
Laurent Garderet, Anita D'Souza, Paulette Jacobs, Anja van Biezen, Stefan Schönland, Nicolaus Kroeger, Curly Morris, Parameswaran Hari
The understanding and treatment of multiple myeloma have dramatically improved in the last years. However, accurate assessment of the response of myeloma to therapy and its subsequent relapse remains a difficult task. Criteria have changed over time and new parameters have recently been incorporated to evaluate the minimal residual disease status. We present a practical approach to assess response and relapse/progression in myeloma in the context of its treatment. A robust reporting schema is crucial to correctly evaluate any treatment protocol and do cross trial comparisons...
March 8, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28283661/structure-guided-schema-recombination-generates-diverse-chimeric-channelrhodopsins
#17
Claire N Bedbrook, Austin J Rice, Kevin K Yang, Xiaozhe Ding, Siyuan Chen, Emily M LeProust, Viviana Gradinaru, Frances H Arnold
Integral membrane proteins (MPs) are key engineering targets due to their critical roles in regulating cell function. In engineering MPs, it can be extremely challenging to retain membrane localization capability while changing other desired properties. We have used structure-guided SCHEMA recombination to create a large set of functionally diverse chimeras from three sequence-diverse channelrhodopsins (ChRs). We chose 218 ChR chimeras from two SCHEMA libraries and assayed them for expression and plasma membrane localization in human embryonic kidney cells...
March 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28280501/high-throughput-and-computational-study-of-leaf-senescence-through-a-phenomic-approach
#18
Jae Il Lyu, Seung Hee Baek, Sukjoon Jung, Hyosub Chu, Hong Gil Nam, Jeongsik Kim, Pyung Ok Lim
Leaf senescence is influenced by its life history, comprising a series of developmental and physiological experiences. Exploration of the biological principles underlying leaf lifespan and senescence requires a schema to trace leaf phenotypes, based on the interaction of genetic and environmental factors. We developed a new approach and concept that will facilitate systemic biological understanding of leaf lifespan and senescence, utilizing the phenome high-throughput investigator (PHI) with a single-leaf-basis phenotyping platform...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28276984/source-memory-that-encoding-was-self-referential-the-influence-of-stimulus-characteristics
#19
Kelly A Durbin, Karen J Mitchell, Marcia K Johnson
Decades of research suggest that encoding information with respect to the self improves memory (self-reference effect, SRE) for items (item SRE). The current study focused on how processing information in reference to the self affects source memory for whether an item was self-referentially processed (a source SRE). Participants self-referentially or non-self-referentially encoded words (Experiment 1) or pictures (Experiment 2) that varied in valence (positive, negative, neutral). Relative to non-self-referential processing, self-referential processing enhanced item recognition for all stimulus types (an item SRE), but it only enhanced source memory for positive words (a source SRE)...
February 8, 2017: Memory
https://www.readbyqxmd.com/read/28275048/brain-machine-interfaces-from-basic-science-to-neuroprostheses-and-neurorehabilitation
#20
REVIEW
Mikhail A Lebedev, Miguel A L Nicolelis
Brain-machine interfaces (BMIs) combine methods, approaches, and concepts derived from neurophysiology, computer science, and engineering in an effort to establish real-time bidirectional links between living brains and artificial actuators. Although theoretical propositions and some proof of concept experiments on directly linking the brains with machines date back to the early 1960s, BMI research only took off in earnest at the end of the 1990s, when this approach became intimately linked to new neurophysiological methods for sampling large-scale brain activity...
April 2017: Physiological Reviews
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