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Hypoparathyroidism

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https://www.readbyqxmd.com/read/28196195/association-of-otolaryngology-resident-duty-hour-restrictions-with-procedure-specific-outcomes-in-head-and-neck-endocrine-surgery
#1
Aaron Smith, Lauren Braden, Jim Wan, Merry Sebelik
Importance: Graduate medical education has undergone a transformation from traditional long work hours to a restricted plan to allow adequate rest for residents. The initial goal of this restriction is to improve patient outcomes. Objective: To determine whether duty hour restrictions had any impact on surgery-specific outcomes by analyzing complications following thyroid and parathyroid procedures performed before and after duty hour reform. Design, Setting, and Participants: Retrospective cross-sectional analysis of the National Inpatient Sample (NIS)...
February 9, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28184212/the-daily-consumption-of-cola-can-determine-hypocalcemia-a-case-report-of-postsurgical-hypoparathyroidism-related-hypocalcemia-refractory-to-supplemental-therapy-with-high-doses-of-oral-calcium
#2
Valentina Guarnotta, Serena Riela, Marina Massaro, Sebastiano Bonventre, Angela Inviati, Alessandro Ciresi, Giuseppe Pizzolanti, Salvatore Benvenga, Carla Giordano
The consumption of soft drinks is a crucial factor in determining persistent hypocalcemia. The aim of the study is to evaluate the biochemical mechanisms inducing hypocalcemia in a female patient with usual high consumption of cola drink and persistent hypocalcemia, who failed to respond to high doses of calcium and calcitriol supplementation. At baseline and after pentagastrin injection, gastric secretion (Gs) and duodenal secretion (Ds) samples were collected and calcium and total phosphorus (Ptot) concentrations were evaluated...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28181426/site-specific-difference-of-bone-geometry-indices-in-hypoparathyroid-patients
#3
Hye Sun Park, Da Hea Seo, Yumie Rhee, Sung Kil Lim
BACKGROUND: Hypoparathyroid patients often have a higher bone mineral density (BMD) than the general population. However, an increase in BMD does not necessarily correlate with a solid bone microstructure. This study aimed to evaluate the bone microstructure of hypoparathyroid patients by using hip structure analysis (HSA). METHODS: Ninety-five hypoparathyroid patients >20 years old were enrolled and 31 of them had eligible data for analyzing bone geometry parameters using HSA...
February 8, 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28167381/parathyroid-reimplantation-with-pr-fast-technique-in-unselected-patients-during-thyroidectomy-a-case-series-with-long-term-follow-up-confirming-graft-vitality-and-parathormone-production
#4
Giuseppe Cavallaro, Olga Iorio, Marco Centanni, Lucilla Gargano, Susanna Del Duca, Angela Gurrado, Natale Porta, Vincenzo Petrozza, Mario Testini, Giorgio De Toma
INTRODUCTION: Parathyroid damage or unintentional excision still affect thyroid surgery and may cause permanent hypoparathyroidism. The only way to recover the excised or ischemic gland functionality is still reimplantation. Many sites of reimplantation have been described, each of one showing both advantages and drawbacks. The aim of this study is to verify results of a new procedure called PR-FaST: Parathyroid Reimplantation in Forearm Subcutaneous Tissue, in a series of unselected patients after long-term follow-up...
February 3, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28165567/surgical-safety-analysis-of-retaining-the-glands-in-papillary-thyroid-microcarcinoma
#5
B Ding, J-F Yu, W Sun, N-F Ma
OBJECTIVE: The objective of the present study was to analyze the surgical safety of retaining the glands in papillary thyroid microcarcinoma (mPTC). PATIENTS AND METHODS: 156 cases of mPTC were retrospectively reviewed and divided into four groups according to the treatment: group A (conservative follow-up group, 30 cases), group B (total resection of unilateral gland combined with isthmic resection, 48 cases), group C (total resection of unilateral gland combined with subtotal resection of contralateral gland, 47 cases), and group D (total resection of bilateral glands, 31 cases)...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28163524/afebrile-seizures-as-initial-symptom-of-hypocalcemia-secondary-to-hypoparathyroidism
#6
Anastasia Gkampeta, Eftyxia Kouma, Anastasia Touliopoulou, Efstathios Aggelopoulos, Eleni Vourti
Hypocalcemia is rare in childhood and caused, among other conditions, by hypoparathyroidism. DiGeorge syndrome is the most common cause of hypoparathyroidism in childhood. Presentation of a rare cause of hypocalcemia in childhood and the necessity of measuring serum electrolyte levels in patients presenting with afebrile seizures. a 7.5-year-old female child presented with afebrile seizures lasting 5 min with postictal drowsiness. A similar episode 1 month ago is described. On admission, a positive Trousseau sign, papilledema, and long QTc on electrocardiography were detected...
December 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28160154/status-dystonicus-in-a-child-with-familial-idiopathic-hypoparathyroidism
#7
Suresh Kumar Angurana, Jayashree Muralidharan, Devi Dayal, Javed Ismail
Hypoparathyroidism leading to status dystonicus is rarely reported in literature. The authors present an 8-y-old girl with idiopathic familial hypoparathyroidism who presented with status dystonicus. She was managed successfully with midazolam infusion, calcium and vitamin D supplementation, and oral anti-dystonia drugs.
February 4, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28141553/early-predictors-of-post-thyroidectomy-hypoparathyroidism
#8
Karol Sieniawski, Krzysztof Kaczka, Katarzyna Paduszyńska, Wojciech Fendler, Bartłomiej Tomasik, Lech Pomorski
: Thyroid surgery is the most commonly performed procedure in the field of endocrine surgery. Studies are still ongoing on the development of a single algorithm for diagnosis and care of patients at risk of postoperative hypoparathyroidism. The aim of the study was to determine the biochemical marker that would allow the most accurate diagnosis of patient groups at risk of developing hypoparathyroidism and to identify risk factors for this disorder. MATERIAL AND METHODS: The prospective study included 142 consecutive patients undergoing total thyroidectomy for benign goiter from January 1st 2014 to December 31st 2015...
December 1, 2016: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28138333/short-stature-and-hypoparathyroidism-in-a-child-with-kenny-caffey-syndrome-type-2-due-to-a-novel-mutation-in-fam111a-gene
#9
Mary B Abraham, Dong Li, Dave Tang, Susan M O'Connell, Fiona McKenzie, Ee Mun Lim, Hakon Hakonarson, Michael A Levine, Catherine S Choong
BACKGROUND: Hypoparathyroidism in children is a heterogeneous group with diverse genetic etiologies. To aid clinicians in the investigation and management of children with hypoparathyroidism, we describe the phenotype of a 6-year-old child with hypoparathyroidism and short stature diagnosed with Kenny-Caffey syndrome (KCS) Type 2 and the subsequent response to growth hormone (GH) treatment. CASE PRESENTATION: The proband presented in the neonatal period with hypocalcemic seizures secondary to hypoparathyroidism...
2017: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/28130188/postoperative-hypomagnesaemia-is-not-associated-with-hypocalcemia-in-thyroid-cancer-patients-undergoing-total-thyroidectomy-plus-central-compartment-neck-dissection
#10
Xiaofei Wang, Jingqiang Zhu, Feng Liu, Yanping Gong, Zhihui Li
BACKGROUND: The literature remains scarce and controversial regarding the association of hypomagnesaemia and hypocalcemia after total thyroidectomy. This study aims to assess this association in thyroid cancer patients underwent total thyroidectomy (TT) plus central compartment neck dissection (CCND). METHOD: All consecutive thyroid cancer patients who underwent TT plus CCND were retrospectively reviewed through a prospectively collected database between October 2015 and June 2016 in a tertiary referral hospital...
January 24, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28125944/applying-criteria-of-active-surveillance-to-low-risk-thyroid-papillary-cancer-over-a-decade-how-many-surgeries-and-complications-can-be-avoided
#11
Andrew Griffin, Juan P Brito, Manisha Bahl, Jenny K Hoang
BACKGROUND: The 2015 American Thyroid Association guidelines acknowledged that "an active surveillance management approach can be considered as an alternative to immediate surgery" in patients with low risk papillary thyroid carcinoma (PTC). The aim of this study is to determine the proportion of PTC that would meet criteria for active surveillance and the surgeries and complications that could have been avoided. METHODS: We retrospectively reviewed 681 patients with thyroid cancer who underwent thyroid surgery from 2003 to 2012...
January 26, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28122587/diseases-associated-with-calcium-sensing-receptor
#12
REVIEW
C Vahe, K Benomar, S Espiard, L Coppin, A Jannin, M F Odou, M C Vantyghem
The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary calcium excretion. The diseases caused by an abnormality of the CaSR are genetically determined or are more rarely acquired. The genetic diseases consist of hyper- or hypocalcemia disorders. Hypercalcaemia disorders are related to inactivating mutations of the CASR gene either heterozygous (autosomal dominant familial benign hypercalcaemia, still named hypocalciuric hypercalcaemia syndrome type 1) or homozygous (severe neonatal hyperparathyroidism)...
January 25, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28121013/incidental-parathyroidectomy-during-thyroidectomy-increases-the-risk-of-postoperative-hypocalcemia
#13
Yann-Sheng Lin, Chuen Hsueh, Hsin-Yi Wu, Ming-Chin Yu, Tzu-Chieh Chao
OBJECTIVES/HYPOTHESIS: The correlation between incidental parathyroidectomy (IP) during thyroidectomy and postoperative hypocalcemia remains controversial. Our aim was to investigate the incidence of IP, risk factors, and impact on patient outcomes. STUDY DESIGN: Retrospective cohort study. METHODS: This was a retrospective observational study including 3,186 consecutive patients who underwent thyroidectomy between January 2007 and December 2014...
January 25, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28105137/applicability-of-rapid-intraoperative-parathyroid-hormone-assay-through-fine-needle-aspiration-to-identify-parathyroid-tissue-in-thyroid-surgery
#14
Xue-Hai Bian, Shi-Jie Li, Le Zhou, Chun-Hai Zhang, Guang Zhang, Yan-Tao Fu, Hui Sun
Hypoparathyroidism is a frequent and serious complication of thyroid surgery. Identification and preservation of the parathyroid glands are key factors in managing hypoparathyroidism. The aim of the present study was to investigate the efficacy of rapid intraoperative parathyroid hormone (rIO-PTH) assay levels through fine needle aspiration (FNA) in identifying parathyroids as a parameter in thyroid surgery. rIO-PTH assay through FNA and frozen section examination were performed on 194 suspected parathyroids anatomical structures from 50 consecutive patients undergoing thyroidectomy (rIO-PTH group)...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28102624/partial-monosomy-of-10p-and-duplication-of-another-chromosome-in-two-patients
#15
Sayaka Ohta, Tsuyoshi Isojima, Yoko Mizuno, Motohiro Kato, Masakazu Mimaki, Masafumi Seki, Yusuke Sato, Seishi Ogawa, Junko Takita, Sachiko Kitanaka, Akira Oka
Partial monosomy of 10p is a rare chromosomal abnormality. Common features are hypoparathyroidism, deafness, renal anomalies, distinctive facies, and mental retardation, with phenotypic variability. We report two patients with chromosomal abnormalities identified on single-nucleotide polymorphism (SNP) array analysis. Although patient 1 had common features of monosomy10p, G-banding indicated a normal karyotype. SNP array and fluorescence in situ hybridization (FISH), however, indicated unbalanced translocation of a 10p terminal deletion of 11...
January 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28097314/complications-of-bilateral-neck-dissection-in-thyroid-cancer-from-a-single-high-volume-center
#16
Caitlin McMullen, Daniel Rocke, Jeremy Freeman
Importance: The morbidity of bilateral lateral neck dissection (BLND) for thyroid cancers has not been described in detail. This study delineates the specific complications arising from BLND for thyroid cancers at a single high-volume center. Objective: To determine the morbidity associated with BLNDs for differentiated thyroid cancers at our institution. Design, Setting, and Participants: This was a retrospective review of medical records performed to identify patients having undergone BLNDs for thyroid cancers by a single surgeon at an academic, tertiary medical center in Toronto, Ontario, Canada, from 1988 to 2015...
January 12, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28089996/a-comparison-of-lobectomy-and-total-thyroidectomy-in-patients-with-papillary-thyroid-microcarcinoma-a-retrospective-individual-risk-factor-matched-cohort-study
#17
COMPARATIVE STUDY
Hyemi Kwon, Min Ji Jeon, Won Gu Kim, Suyeon Park, Mijin Kim, Dong Eun Song, Tae-Yon Sung, Jong Ho Yoon, Suck Joon Hong, Tae Yong Kim, Young Kee Shong, Won Bae Kim
OBJECTIVE: Papillary thyroid microcarcinoma (PTMC) accounts for most of the increase in thyroid cancer in recent decades. We compared clinical outcomes and surgical complications of lobectomy and total thyroidectomy (TT) in PTMC patients. DESIGN AND METHODS: In this retrospective individual risk factor-matched cohort study, 2031 patients with PTMC were initially included. Patients who underwent lobectomy or TT were one-to-one matched according to individual risk factors, including age, sex, primary tumor size, extrathyroidal extension, multifocality and cervical lymph node (LN) metastasis...
April 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28071093/management-of-hypoparathyroidism-summary-statement-and-guidelines
#18
Gary Woodward
No abstract text is available yet for this article.
July 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28064342/failure-of-fragmented-parathyroid-gland-autotransplantation-to-prevent-permanent-hypoparathyroidism-after-total-thyroidectomy
#19
Leyre Lorente-Poch, Juan Sancho, Jose Luis Muñoz, Lander Gallego-Otaegui, Carlos Martínez-Ruiz, Antonio Sitges-Serra
PURPOSE: Parathyroid autotransplantation during total thyroidectomy leads to higher rates of postoperative hypocalcaemia. It has been argued, however, that it prevents permanent hypoparathyroidism. The impact of autografted normal parathyroid gland fragments on long-term parathyroid status has not been assessed properly. To clarify this, the short- and long-term parathyroid function was assessed in patients with three glands remaining in situ after total thyroidectomy, in whom the fourth gland was either autotransplanted (Tx) or accidentally resected (AR)...
January 7, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28056318/-clinical-characteristics-of-adult-onset-primary-hypoparathyroidism-a-retrospective-analysis-of-200-cases
#20
T T Quan, Y P Li, O Wang, Y Jiang, W B Xia, M Li, X Q Cheng, X W Meng, X P Xing
Objective: To study the clinical characteristics of primary hypoparathyroidism in adults. Methods: The clinical data of 200 cases with adult-onset primary hypoparathyroidism in Peking Union Medical College Hospital during December 1987 to December 2015 were collected and analyzed retrospectively. Among them, 128 cases were followed up for a median period of 3 years. Results: The major manifestations at their first visits were tetany and numbness in the distal extremities(81.5%, 163/200 and 62.0%, 124/200). Thirty-two percent of the cases (62 cases) had history of seizures, and 60...
January 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
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