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https://www.readbyqxmd.com/read/29055289/trends-in-incidence-and-associated-risk-factors-of-suicide-mortality-among-breast-cancer-patients
#1
Apostolos Gaitanidis, Michail Alevizakos, Michail Pitiakoudis, Doreen Wiggins
OBJECTIVE: Breast cancer patients are associated with an increased risk for committing suicide. The purpose of this study is to study the trends in the incidence of suicide mortality and identify pertinent risk factors among patients with breast cancer. METHODS: A retrospective examination of the Surveillance Epidemiology and End Results (SEER) database between years 1973 and 2013 was performed. RESULTS: Overall, 474,128 patients were identified of which 773 had committed suicide...
October 21, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29055277/structural-photophysical-and-theoretical-studies-of-imidazole-based-excited-state-intramolecular-proton-transfer-molecules
#2
Sivaraman Somasundaram, Eswaran Kamaraj, Su Jin Hwang, Sanghyuk Park
Imidazole-based excited state intramolecular proton transfer (ESIPT) blue fluorescent molecules, 2-(1-(4-chlorophenyl)-4,5-diphenyl-1H-imidazol-2-yl)phenol (BHPI-Cl) and 2-(1-(4-bromophenyl)-4,5-diphenyl-1H-imidazol-2-yl)phenol (BHPI-Br) were designed and synthesized by Debus-Radziszewski method through a one-pot multicomponent reaction in high yield. The synthesized compounds were fully characterized by (1)H NMR, (13)C NMR, FT-IR, FT-Raman, GC-Mass, and elemental analysis. The molecular structures in single crystal lattice were studied by X-ray crystallographic analysis...
October 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055276/nonadiabatic-dynamics-simulation-of-photoisomerization-mechanism-of-the-second-stablest-isomer-of-n-salicilydenemethylfurylamine
#3
Aihua Gao, Jianpeng Li, Dehua Wang, Xiaoguang Ma, Meishan Wang
The photoisomerization processes of the second stablest isomer in the aromatic Schiff base, N-salicilydenemethylfurylamine, in the gas phase have been studied by static electronic structure calculations and surface-hopping dynamics simulations based on the Zhu-Nakamura theory. Various stable structures are obtained in the optimization because of different orientations of methyl-furyl part with respect to the salicylaldimine part and different orientations of hydroxy group with respect to the benzene ring. Upon photoexcitation into the first excited state, bond isomerization in the salicylaldimine part is completely suppressed until the strong excited-state hydrogen bond is broken...
October 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055270/executive-functioning-concern-about-falling-and-quadriceps-strength-mediate-the-relationship-between-impaired-gait-adaptability-and-fall-risk-in-older-people
#4
Maria Joana D Caetano, Stephen R Lord, Matthew A Brodie, Daniel Schoene, Paulo H S Pelicioni, Daina L Sturnieks, Jasmine C Menant
BACKGROUND: Reduced ability to adapt gait, particularly under challenging conditions, may be an important reason why older adults have an increased risk of falling. This study aimed to identify cognitive, psychological and physical mediators of the relationship between impaired gait adaptability and fall risk in older adults. METHODS: Fifty healthy older adults (mean±SD: 74±7years) were categorised as high or low fall risk, based on past falls and their performance in the Physiological Profile Assessment...
October 16, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29055249/peptide-nucleic-acid-as-a-selective-recognition-element-for-electrochemical-determination-of-hg-2
#5
Agnieszka Bala, Łukasz Górski
A novel electrochemical PNA-based biosensor for the determination of Hg(2+) is described. The receptor layer, containing single strands of polythymine PNA (peptide nucleic acid), was formed at the surface of gold electrode. Due to the presence of thymine bases and peptide bonds, an interaction between Hg(2+) ion and receptor layer occurs. The influence of chain modification - PNA vs. DNA - and type of redox marker - anionic AQMS-Na (sodium salt of anthraquinone-2-sulfonic acid) and Fe(II/III) (potassium ferri/ferrocyanide) or cationic MB (methylene blue) and RuHex (hexaammineruthenium(III) chloride) - were studied...
October 12, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/29055246/comparative-analysis-of-multiple-representative-components-in-the-herb-pair-astragali-radix-curcumae-rhizoma-and-its-single-herbs-by-uplc-qqq-ms
#6
Gang Yin, Xiaolan Cheng, Weiwei Tao, Yu Dong, Yong Bian, Wenhua Zang, Decai Tang
The herb-pair, Astragali Radix (AR) and Curcumae Rhizoma (CR), often occurs in traditional herbal prescriptions used for cancer treatment in Asian areas. In clinical application, the AR-CR herb pair was often produced by different preparation methods or with raw materials from different sources, which raised a challenge for quality control of the herb-pair medicines. In this paper, ultra high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry method (UPLC-QQQ-MS) was applied for the first time to simultaneously determine 17 main bioactive components for quality control of AR-CR herb pair...
October 14, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29055223/pituitary-apoplexy-a-single-center-retrospective-study-from-the-neurosurgical-perspective-and-review-of-the-literature
#7
Agnieszka Grzywotz, Bernadette Kleist, Lars C Möller, Volkmar H Hans, Sophia Göricke, Ulrich Sure, Oliver Müller, Ilonka Kreitschmann-Andermahr
OBJECTIVE: Thunderclap headache and visual disturbances are typical clinical features of pituitary apoplexy (PA). Because of the acute symptomatology, many patients are referred to a neurosurgical department without prior endocrinological assessment. It is the aim of the present study to analyze initial presenting symptoms, outcome and associated endocrine disturbances in a cohort of patients with pituitary apoplexy primarily seen by neurosurgeons. PATIENTS AND METHODS: Retrospective single-center study in a neurosurgical department...
October 10, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29055216/thoracic-manual-therapy-is-not-more-effective-than-placebo-thoracic-manual-therapy-in-patients-with-shoulder-dysfunctions-a-systematic-review-with-meta-analysis
#8
REVIEW
Paolo Bizzarri, Luca Buzzatti, Erik Cattrysse, Aldo Scafoglieri
BACKGROUND: Manual treatments targeting different regions (shoulder, cervical spine, thoracic spine, ribs) have been studied to deal with patients complaining of shoulder pain. Thoracic manual treatments seem able to produce beneficial effects on this group of patients. However, it is not clear whether the patient improvement is a consequence of thoracic manual therapy or a placebo effect. OBJECTIVES: To compare the efficacy of thoracic manual therapy and placebo thoracic manual treatment for patients with shoulder dysfunction...
October 14, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29055159/genomics-of-natural-populations-evolutionary-forces-that-establish-and-maintain-gene-arrangements-in-drosophila-pseudoobscura
#9
Zachary L Fuller, Gwilym D Haynes, Stephen Richards, Stephen W Schaeffer
The evolution of complex traits in heterogeneous environments may shape the order of genes within chromosomes. Drosophila pseudoobscura has a rich gene arrangement polymorphism that allows one to test evolutionary genetic hypotheses about how chromosomal inversions are established in populations. D. pseudoobscura has >30 gene arrangements on a single chromosome that were generated through a series of overlapping inversion mutations with > 10 inversions with appreciable frequencies and wide geographic distributions...
October 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29055156/type-2-diabetes-remission-2-years-post-roux-en-y-gastric-bypass-and-sleeve-gastrectomy-the-role-of-the-weight-loss-and-comparison-of-diarem-and-diabetter-scores
#10
A Pucci, U Tymoszuk, W H Cheung, J M Makaronidis, S Scholes, G Tharakan, M Elkalaawy, M Guimaraes, M Nora, M Hashemi, A Jenkinson, M Adamo, M Monteiro, N Finer, R L Batterham
AIMS: The comparative efficacy of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy on Type 2 diabetes remission and the role of weight loss are unclear. The DiaRem Type 2 diabetes remission prediction score uses HbA1c , age and Type 2 diabetes medications but not Type 2 diabetes duration. The aim of this study was to compare the predictive value of the DiaRem score with the DiaBetter score that includes Type 2 diabetes duration, upon combined (complete plus partial) 2-year post-surgery Type 2 diabetes remission in people following RYGB and sleeve gastrectomy, and to investigate the relationship between weight loss and Type 2 diabetes remission...
October 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29055150/distinct-sources-of-gene-flow-produce-contrasting-population-genetic-dynamics-at-different-range-boundaries-of-a-choristoneura-budworm
#11
Gwylim S Blackburn, Bryan M T Brunet, Kevin Muirhead, Michel Cusson, Catherine Béliveau, Roger C Levesque, Lisa M Lumley, Felix A H Sperling
Populations are often exposed to multiple sources of gene flow, but accounts are lacking of the population genetic dynamics that result from these interactions or their effects on local evolution. Using a genomic clines framework applied to 1195 SNPs, we documented genome-wide, locus-specific patterns of introgression between Choristoneura occidentalis biennis spruce budworms and two ecologically divergent relatives, C. o. occidentalis and C. fumiferana, that it interacts with at alternate boundaries of its range...
October 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29055125/vascular-endothelial-growth-factor-vegf-related-single-nucleotide-polymorphisms-rs10738760-and-rs6921438-are-not-associated-with-diabetic-retinopathy-dr-in-slovenian-patients-with-type-2-diabetes-mellitus-t2dm
#12
Rifet Terzić, Ines Cilenšek, Ruda Zorc Pleskovič, Sara Mankoč, Aleksandra Milutinović
Diabetic retinopathy (DR) is a complication of diabetes characterized by vascular permeability, increased tissue ischemia, and angiogenesis. One of the most important proteins involved in angiogenesis is vascular endothelial growth factor (VEGF, also known as VEGFA). A previous study demonstrated that two single nucleotide polymorphisms (SNPs), rs6921438 and rs10738760, account for nearly half the variation in circulating VEGF levels. The aim of our study was to assess the association between rs6921438 and rs10738760 and DR in Slovenian patients with type 2 diabetes mellitus (T2DM)...
October 20, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29055113/accelerating-patient-access-to-novel-biologics-using-stable-pool-derived-product-for-non-clinical-studies-and-single-clone-derived-product-for-clinical-studies
#13
Trent P Munro, Kim Le, Huong Le, Li Zhang, Jennitte Stevens, Neil Soice, Sabrina A Benchaar, Robert W Hong, Chetan T Goudar
Cell cloning and subsequent process development activities are on the critical path directly impacting the timeline for advancement of next generation therapies to patients with unmet medical needs. The use of stable cell pools for early stage material generation and process development activities is an enabling technology to reduce timelines. To successfully use stable pools during development, it is important that bioprocess performance and requisite product quality attributes be comparable to those observed from clonally derived cell lines...
October 21, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/29055111/genetic-based-dissection-of-arsenic-accumulation-in-maize-using-a-genome-wide-association-analysis-method
#14
Zhan Zhao, Huaisheng Zhang, Zhongjun Fu, Hao Chen, Yanan Lin, Pengshuai Yan, Weihua Li, Huiling Xie, Zhanyong Guo, Xuehai Zhang, Jihua Tang
Understanding the mechanism of arsenic (As) accumulation in plants is important in reducing As's toxicity to plants and its potential risks to human health. Here, we performed a genome-wide association study to dissect the genetic basis of the As contents of different maize tissues in Xixian, which was irrigated with As-rich surface water, and Changge using an association population consisting of 230 representative inbred maize lines. Phenotypic data revealed a wide normal distribution and high repeatability for the As contents in maize tissues...
October 21, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29055096/an-improved-method-for-bivariate-meta-analysis-when-within-study-correlations-are-unknown
#15
Chuan Hong, Richard D Riley, Yong Chen
Multivariate meta-analysis, which jointly analyzes multiple and possibly correlated outcomes in a single analysis, is becoming increasingly popular in recent years. An attractive feature of the multivariate meta-analysis is its ability to account for the dependence between multiple estimates from the same study. However, standard inference procedures for multivariate meta-analysis require the knowledge of within-study correlations, which are usually unavailable. This limits standard inference approaches in practice...
October 21, 2017: Research Synthesis Methods
https://www.readbyqxmd.com/read/29055078/neoadjuvant-chemoradiation-for-non-metastatic-pancreatic-cancer-increases-margin-negative-and-node-negative-rates-at-resection
#16
Camille A Berriochoa, May Abdel-Wahab, Charles Marc Leyrer, Alok Khorana, R Matthew Walsh, Aryavarta M S Kumar
AIM: Preoperative chemoradiation for non-metastatic pancreatic cancer patients has been associated with improved outcomes; however, direct comparisons to adjuvant therapy are limited. METHODS: Single institution data were obtained for non-metastatic pancreatic cancer patients treated with concurrent chemoradiation +/- resection from 2011-2014. Univariate analyses were performed to evaluate clinical and pathologic outcomes. RESULTS: Fifty-two well matched patients met inclusion criteria (neoadjuvant chemoradiation = 21, adjuvant chemoradiation = 11, definitive = 20)...
October 20, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29055069/evidence-of-evolutionary-optimization-of-fatty-acid-length-and-unsaturation
#17
I Galván
The lipid composition of cell membranes exerts a crucial influence on cell physiology. Indeed, one double bond triggers membrane fluidity, essential for cell functionality, but additional double bonds increase the susceptibilty to peroxidation, which produces reactive compounds that impair the viability of cells. It has therefore been suggested, but never tested in an extensive comparative context, that the composition of membrane fatty acids has been optimized during evolution. A similar prediction has been made for fatty acid chain length, on which susceptibility to peroxidation also depends...
October 20, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29055064/clinical-relevance-of-peroxisome-proliferator-activated-receptor-%C3%AE-gene-polymorphisms-with-sepsis
#18
Yu Liu, Wenhui Wan, Fang Fang, Lei Guo, Yusheng Zhao, Xinghu Zhang, Fang Huang
BACKGROUND: Peroxisome proliferator-activated receptor-γ (PPARγ) is a regulator of inflammation. This study aimed to explore associations between PPARγ gene single-nucleotide polymorphisms (SNPs) and susceptibility to and clinical outcome of sepsis in the North China Han population. METHODS: This study included 303 patients with sepsis and 303 controls. We conducted genetic typing for 13 common PPARγ gene SNPs (improved multiplex ligation detection reaction), linkage disequilibrium mapping, and haplotype inference...
October 21, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29055059/application-of-the-bbcid-mass-spectrometry-approach-for-protein-glycosylation-and-phosphorylation-analysis
#19
Narciso Couto, Liliya Davlyatova, Caroline A Evans, Phillip C Wright
RATIONALE: Post-translational modified peptides analysis by mass spectrometry (MS) remains incomplete, in part due to incomplete sampling of all peptides which is inherent to traditional data-dependent acquisition (DDA). An alternative MS approach, data-independent acquisition (DIA), enables comprehensive recording of all detectable precursor and product ions, independent of precursor intensity. The use of broad band collision-induced dissociation (bbCID), a DIA method, was evaluated for the identification of protein glycosylation and phosphorylation...
October 21, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29054987/theranostic-radiolabeled-anti-cd20-sdab-for-targeted-radionuclide-therapy-of-non-hodgkin-lymphoma
#20
Ahmet Krasniqi, Matthias D'Huyvetter, Catarina Xavier, Kevin Van der Jeught, Serge Muyldermans, José Van Der Heyden, Tony Lahoutte, Jan Tavernier, Nick Devoogdt
Anti-CD20 radioimmunotherapy is an effective approach for therapy of relapsed or refractory CD20pos lymphomas, but faces limitations due to poor tumor penetration and undesirable pharmacokinetics of full antibodies. Camelid single-domain Ab fragments (sdAbs) might circumvent some of the limitations of radiolabeled full antibodies. In this study, a set of hCD20-targeting sdAbs was generated and their capacity to bind hCD20 was evaluated in vitro and in vivo. A lead sdAb, sdAb 9079, was selected based on its specific tumor targeting and significant lower kidney accumulation compared to other sdAbs...
October 20, 2017: Molecular Cancer Therapeutics
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