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https://www.readbyqxmd.com/read/29451347/a-rare-case-of-ectopic-papillary-thyroid-carcinoma-transformed-into-squamous-cell-carcinoma
#1
Hironao Yasuoka, Yasushi Nakamura, Ken-Ichi Yoshida, Toshiro Shimo, Masayuki Tori, Yuuki Matsui, Yasushi Sakamaki, Masahiko Tsujimoto
A rare case of a metastatic ectopic papillary thyroid carcinoma (PTC) of the lung that transformed into a squamous cell carcinoma (SCC) that resembles pulmonary SCC is reported. A subcutaneous ectopic PTC in the left anterior neck area, together with a normal thyroid gland, were excised. The ectopic PTC showed thyroglobulin, TTF-1 and PAX-8 immunoreactivity and a BRAF V600E mutation. During the post-operative follow-up period, a rapidly growing 2 cm nodular lesion in the lower left lobe of the lung was detected...
February 16, 2018: Pathology International
https://www.readbyqxmd.com/read/29449788/rrs1-gene-expression-involved-in-the-progression-of-papillary-thyroid-carcinoma
#2
Feng Chen, Yaqiong Jin, Lin Feng, Jie Zhang, Jun Tai, Jin Shi, Yongbo Yu, Jie Lu, Shengcai Wang, Xin Li, Ping Chu, Shujing Han, Shujun Cheng, Yongli Guo, Xin Ni
Background: Papillary thyroid carcinoma (PTC) is one of the most frequent malignancies of the endocrine system, whose mechanisms of pathogenesis, progression and prognosis are still far from being clearly elucidated. Despite an increasing body of evidences highlights ribosome biogenesis regulator homolog (RRS1) as a ribosome biogenesis protein in yeast and plants, little is known about human RRS1 function. Methods: Proliferation, cell cycle and apoptosis of PTC cells were assessed following the knockdown of RRS1 expression though MTT, colony formation assay, and flow cytometry...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29446856/thyroid-carcinoma-producing-%C3%AE-human-chorionic-gonadotropin-shows-different-clinical-behavior
#3
Haiyan Gu, Shaofeng Sui, Xiujie Cui, Bo Han, Chunyan Zhang, Mei Qi, Congcong Li, Zhiyan Liu
Columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is an unusual neoplasm, the clinical behavior of which mainly depends on the encapsulation or infiltration. Patients with extensive extrathyroidal extension usually have an aggressive biological behavior. This study confirmed that beta-human chorionic gonadotropin (β-hCG) secreting invasive CCV-PTC has good prognosis comparing with a cohort of follicular cell differentiated thyroid carcinoma. On the contrary, positive immunoreaction with β-hCG was proved in three anaplastic thyroid carcinoma patients showing aggressive clinical courses...
February 15, 2018: Pathology International
https://www.readbyqxmd.com/read/29445865/risk-of-recurrence-in-a-homogeneously-managed-pt3-differentiated-thyroid-carcinoma-population
#4
Nathalie Chereau, Etienne Dauzier, Gaëlle Godiris-Petit, Séverine Noullet, Isabelle Brocheriou, Laurence Leenhardt, Camille Buffet, Fabrice Menegaux
BACKGROUND: International guidelines for the management of differentiated thyroid cancers are based on the 7th TNM classification: pT3 tumors are defined as differentiated thyroid cancers (DTCs) measuring more than 4 cm in their greatest dimension that are limited to the thyroid or any tumor with minimal extrathyroidal extension (ETE; sternothyroid muscle or perithyroid soft tissues). Differences in clinicohistological features and prognosis among patients with pT3 tumors remain controversial, and studies regarding pT3 subgroups are lacking...
February 14, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29443557/adolescent-pregnancy-prevention-among-youths-living-in-group-care-homes-a-cluster-randomized-controlled-trial
#5
Roy F Oman, Sara K Vesely, Jennifer Green, Kristen Clements-Nolle, Minggen Lu
OBJECTIVES: To determine if the Power Through Choices (PTC) intervention can increase the use of birth control and reduce pregnancy among system-involved youths living in group care homes. METHODS: We performed a 2-arm cluster randomized controlled trial involving group care homes operated by child welfare or juvenile justice systems in California, Maryland, and Oklahoma with assessments immediately before and after the intervention, and at 6- and 12-month follow-up...
February 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29439716/risk-factors-of-lateral-lymph-node-metastasis-in-cn0-papillary-thyroid-carcinoma
#6
Daixing Hu, Jing Zhou, Wei He, Jie Peng, Yijia Cao, Haoyu Ren, Yu Mao, Yi Dou, Wei Xiong, Qi Xiao, Xinliang Su
BACKGROUND: Cervical lymph node metastasis of papillary thyroid carcinoma (PTC) is common. However, whether undergoing prophylactic central lymph node (CLN) dissection or lateral lymph node (LLN) dissections to prevent metastasis is still controversial. This study aimed to retrospectively investigate the risk factors of LLN metastasis in clinical lymph node-negative (cN0) PTC patients. METHODS: We retrospectively studied 783 lymph node-negative (cN0) PTC patients who underwent total thyroidectomy plus CLN dissection and LLN dissection...
February 13, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29439612/a-nomogram-based-on-the-characteristics-of-metastatic-lymph-nodes-to-predict-papillary-thyroid-carcinoma-recurrence
#7
Jianyong Lei, Jinjing Zhong, Zhihui Li, Tao Wei, Rixiang Gong, Jinqiang Zhu
BACKGROUND AND AIMS: The extent of metastatic LN invasion was not considered in the postoperative stratification of the recurrence risk of papillary thyroid carcinoma (PTC) in the 2015 American Thyroid Association (ATA) guidelines, and the recommended risk stratification cannot be applied to individuals. A nomogram based on these risk factors was developed based on the risk factors to predict individual recurrence risk. PATIENTS AND METHODS: Data from 1788 PTC patients at the West China Hospital and 306 cases from the Shang Jin Nan Fu Hospital between August 2013 and July 2015 were included in our study...
February 14, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29439059/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features
#8
Isabel Amendoeira, Tiago Maia, M Sobrinho-Simões
The 2017 edition of the WHO book on Classification of Tumours of Endocrine Organs includes a new section entitled "Other encapsulated follicular-patterned thyroid tumours", in which the newly created NIFTP (Non-invasive follicular thyroid neoplasm with papillary-like nuclear features) is identified and detailed described. Despite deleting the word "carcinoma" from its name, NIFTP is not a benign tumor either, and is best regarded as a neoplasm with "very low malignant potential"...
February 9, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29438906/alteration-in-the-serum-concentrations-of-fgf19-fgfr4-and-%C3%AE-klotho-in-patients-with-thyroid-cancer
#9
Ewelina Motylewska, Tomasz Stępień, Magdalena Borkowska, Krzysztof Kuzdak, Agnieszka Siejka, Jan Komorowski, Henryk Stępień, Hanna Ławnicka
INTRODUCTION: βKlotho (βKL) is known to act as co-receptor for fibroblast growth factor receptor 4 (FGFR4) which is the main cognate receptor for fibroblast growth factor 19 (FGF19). Dysregulation of this FGF19/FGFR4/βKL signaling axis has been implicated in the pathogenesis of several cancers. However, its role in the pathogenesis of thyroid cancer has not been determined. MATERIALS AND METHODS: The aim of this study was to assess FGF19, FGFR4 and βKL concentrations in a group of 36 patients with papillary thyroid cancer (PTC), 11 patients with follicular thyroid cancer (FTC), 9 patients with anaplastic thyroid cancer (ATC) and a group of 19 subjects with multinodular nontoxic goiter (MNG)...
February 10, 2018: Cytokine
https://www.readbyqxmd.com/read/29438531/characteristics-of-follicular-variant-papillary-thyroid-carcinoma-in-a-pediatric-cohort
#10
S L Samuels, L F Surrey, C P Hawkes, M Amberge, S Mostoufi-Moab, J E Langer, N S Adzick, K Kazahaya, T Bhatti, Z Baloch, V A LiVolsi, A J Bauer
Context: In adults, non-invasive follicular variant papillary thyroid carcinoma (FVPTC) is considered low risk for metastasis and persistent/recurrent disease. Objective: The goal of this study was to assess the clinical, sonographic, and histopathological features of FVPTC in a pediatric cohort. Design: A retrospective review of subjects < 19 years of age with papillary thyroid carcinoma (PTC) who underwent thyroidectomy between January 2010 and July 2015...
February 8, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29438012/hedgehog-reciprocally-controls-trafficking-of-smo-and-ptc-through-the-smurf-family-of-e3-ubiquitin-ligases
#11
Shuang Li, Shuangxi Li, Bing Wang, Jin Jiang
Hedgehog (Hh) induces signaling by promoting the reciprocal trafficking of its receptor Patched (Ptc) and the signal transducer Smoothened (Smo), which is inhibited by Ptc, at the cell surface. We identified Smurf family E3 ubiquitin ligases as essential for Smo ubiquitylation and cell surface clearance and demonstrated that Smurf family members mediate the reciprocal trafficking of Ptc and Smo in Drosophila melanogaster G protein-coupled receptor kinase 2 (Gprk2)-mediated phosphorylation of Smurf promoted Smo ubiquitylation by increasing the recruitment of Smurf to Smo, whereas protein kinase A (PKA)-mediated phosphorylation of Smo caused Smurf to dissociate from Smo, thereby inhibiting Smo ubiquitylation...
February 6, 2018: Science Signaling
https://www.readbyqxmd.com/read/29437771/hepatotoxicity-associated-with-vismodegib
#12
Prabhjot S Bedi, Manoj P Rai, Nishant Tageja, Heather Laird-Fick
An 82-year-old Caucasian woman with a history of basal cell carcinoma on vismodegib presented with nausea, vomiting and intermittent abdominal pain. Laboratory results were remarkable for the elevation of liver enzymes. Endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholangiogram (PTC) did not show evidence of intrahepatic or extrahepatic obstruction of the biliary tract. During PTC external biliary catheter was placed; however, bilirubin continued to rise. Further, laboratory work-up and imaging studies ruled out other possible aetiologies for hepatotoxicity such as infections, autoimmune hepatitis and other drugs known to be hepatotoxic thus leaving vismodegib the most likely cause of hepatotoxicity...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29436694/lrig1-negatively-regulates-ret-mutants-and-is-downregulated-in-thyroid-cancer
#13
David Lindquist, Fernando C Alsina, Carl Herdenberg, Catharina Larsson, Jo Höppener, Na Wang, Gustavo Paratcha, Miklós Tarján, Tibor Tot, Roger Henriksson, Håkan Hedman
Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are characterized by genomic rearrangements and point mutations in the proto-oncogene RET. Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a suppressor of various receptor tyrosine kinases, including RET. LRIG1 expression levels are associated with patient survival in many cancer types. In the present study, we investigated whether the oncogenic RET mutants RET2A (C634R) and RET2B (M918T) were regulated by LRIG1, and the possible effects of LRIG1 expression in thyroid cancer were investigated in three different clinical cohorts and in a RET2B-driven mouse model of MTC...
February 9, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29436563/the-rising-trend-in-papillary-thyroid-carcinoma-true-increase-or-over-diagnosis
#14
Manar H Hajeer, Heyam A Awad, Niveen I Abdullah, Ghadeer H Almuhaisen, Loay E Abudalu
To assess the changes in parameters of thyroid carcinoma, particularly papillary type, in the era of widespread use of sensitive diagnostic methods. We aim to investigate whether the increased frequency of thyroid cancer is true or resulted from over diagnosis. Methods: We conducted a retrospective study of 313 cases of thyroid carcinoma diagnosed at Jordan University Hospital and King Hussein Cancer Center from 2007-2015. Papillary carcinoma accounted for 290 (92.7%) of all cases. Cases were sub classified according to demographic features, histological type, size, stage, and other variables...
February 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29435545/ternary-cbe4au4-cluster-a-16-electron-system-with-quasi-planar-tetracoordinate-carbon
#15
Jin-Chang Guo, Lin-Yan Feng, Hua-Jin Zhai
Planar hypercoordinate carbons as exotic chemical species are dominated by 18-electron counting. We report herein a 16-electron planar tetracoordinate carbon (ptC) cluster, CBe4Au4, which is quasi-planar to be exact, being composed of a C center, a square-planar Be4 ring, and four outer Au bridges. The quasi-ptC cluster is established as a global minimum via computer structural searches, located 14.6 kcal mol-1 below the nearest competitor at the CCSD(T) level. It shows thermodynamic and electronic robustness, with a low electron affinity (1...
February 13, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29435194/mirna-dysregulation-and-the-risk-of-metastasis-and-invasion-in-papillary-thyroid-cancer-a-systematic-review-and-meta-analysis
#16
REVIEW
Tiantian Wang, Hao Xu, Ming Qi, Sheng Yan, Xingsong Tian
Thyroid cancer (TC) is the most common endocrine malignancy, with an incidence continuing to grow every year. Although thyroid cancer as a whole is generally indolent and relatively easy to treat, some subtypes carry a higher rate of metastasis and cancer-related mortality. A growing number of studies have focused on the dysregulation of miRNAs in TC. However, differences in methods make comparison of gene profiling data difficult. A meta-analysis of published studies comparing miRNA expression data of invasive thyroid carcinoma with paired non-invasive tumors or normal tissues was performed by searching the literature for "invasion", "thyroid cancer", and "miRNA"...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29435002/tert-promoter-mutations-and-their-correlation-with-braf-and-ras-mutations-in-a-consecutive-cohort-of-145-thyroid-cancer-cases
#17
Andrea Cacciato Insilla, Agnese Proietti, Nicla Borrelli, Elisabetta Macerola, Cristina Niccoli, Paolo Vitti, Paolo Miccoli, Fulvio Basolo
Papillary thyroid carcinoma (PTC) is the most common type of endocrine malignancy and accounts for ~80% of thyroid carcinomas in adults and 90% in children. Risk stratification is important for identifying patients at higher risk and, for this reason, recent advances in molecular genetics of thyroid cancer can be applied to provide novel biomarkers useful in understanding tumor behavior. B-Raf proto-oncogene, serine/threonine kinase (BRAF) and rat sarcoma (RAS) mutations have been widely studied and appear to have an important role in thyroid tumorigenesis...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433884/squamous-differentiation-in-papillary-thyroid-carcinoma-a-rare-feature-of-aggressive-disease
#18
Toni Beninato, Wouter P Kluijfhout, Frederick Thurston Drake, Elham Khanafshar, Jessica E Gosnell, Wen T Shen, Quan-Yang Duh, Insoo Suh
BACKGROUND: Papillary thyroid carcinoma with squamous differentiation (PTC-SD) is a poorly understood pathologic finding of unknown clinical significance. Selected case reports have suggested that PTC-SD is an aggressive tumor with a poor prognosis. Here we present the largest case series of PTC-SD reported in the United States. MATERIALS AND METHODS: The cancer registry at our tertiary care referral center was reviewed to identify all patients from 1995-2015 who had been diagnosed with PTC-SD on initial total thyroidectomy or lymph node dissection for recurrent disease...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29432967/lack-of-effect-of-grastek%C3%A2-on-birch-pollen-induced-allergic-rhinoconjunctivitis-in-the-environmental-exposure-unit
#19
Anne K Ellis, Mark W Tenn, Lisa M Steacy, Daniel E Adams, Andrew G Day, Terry J Walker, Hendrik Nolte
BACKGROUND: Grastek® is a standardized sublingual immunotherapy tablet(SLIT-T) approved for the treatment of grass pollen-induced allergic rhinitis(AR) and conjunctivitis. Many grass-allergic patients are also co-sensitized to birch pollen. Whether Grastek® can confer symptomatic benefits for birch pollen-induced AR symptoms is unknown. OBJECTIVE: To evaluate the treatment effect of Grastek® for birch pollen-induced AR in participants sensitized to both grass and birch pollen using the Environmental Exposure Unit(EEU)...
February 9, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29431057/evolution-in-the-management-of-thyroid-cancer-an-observational-study-in-two-referral-centres-in-belgium
#20
Bernard Peene, Annick Van den Bruel, Carolien Moyson, Brigitte Decallonne
Objective Thyroid cancer incidence is increasing. The rise is most pronounced for microcancers (≤10 mm, T1a). In 2006, landmark European and American guidelines for the management of thyroid cancer were published. We studied thyroid cancer characteristics and initial management before and after 2006. Methods We conducted a retrospective observational study of non-medullary thyroid cancer patients that underwent thyroidectomy in two Belgian referral centres comparing pre-, per- and post-operative management in a cohort before and after 2006...
February 12, 2018: Acta Clinica Belgica
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