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https://www.readbyqxmd.com/read/29683529/morphology-combined-with-ancillary-techniques-an-algorithm-approach-for-thyroid-nodules
#1
Esther Diana Rossi, Maurizio Martini, Sara Capodimonti, Tonia Cenci, Mirna Bilotta, Francesco Pierconti, Alfredo Pontecorvi, Celestino Pio Lombardi, Guido Fadda, Luigi Maria Larocca
OBJECTIVE: Several authors have underlined the limits of morphological analysis mostly in the diagnosis of follicular neoplasms (FN). The application of ancillary techniques (AT), including immunocytochemistry(ICC) and molecular testing (MT), contributes to a better definition of the risk of malignancy(ROM) and management of FN. According to literature, the application of models, including the evaluation of ICC, somatic mutations (i.e. BRAFV 600E ), miRNA analysis is proposed for FNs...
April 23, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29683312/a-simple-perylene-derivative-as-a-solution-processable-cathode-interlayer-for-perovskite-solar-cells-with-enhanced-efficiency-and-stability
#2
Chen Wang, Ping Liu, Huanxin Ju, Quan Yuan, Dongwei Han, Yu Wang, Dong-Ying Zhou, Lai Feng
A simple alcohol-soluble perylene derivative (i.e., tetramethyl ammonium salt of perylene-3,4,9,10-tetracarboxylic acid; TMA-PTC) was prepared and applied as a cathode interlayer (CIL) to modify the PC61 BM/Ag interface in planar p-i-n perovskite solar cells (PeSCs). As a result, the power conversion efficiency (PCE) of the TMA-PTC-based PeSCs is ca. 30% higher than that of the devices without CIL. It was revealed that the enhancement in PCE might be attributed to the improved electron-transporting and hole-blocking properties of the PC61 BM/TMA-PTC/Ag interfaces...
April 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29677534/punicalagin-induces-senescent-growth-arrest-in-human-papillary-thyroid-carcinoma-bcpap-cells-via-nf-%C3%AE%C2%BAb-signaling-pathway
#3
Xian Cheng, Xin Yao, Shichen Xu, Jie Pan, Huixin Yu, Jiandong Bao, Haixia Guan, Rongrong Lu, Li Zhang
Papillary thyroid carcinoma (PTC) is the most common endocrine carcinoma. Our previous study revealed that punicalagin (PUN), an active component from pomegranate, triggered autophagic cell death and DNA damage response (DDR) in papillary thyroid carcinoma BCPAP cells. But the detailed anti-cancer mechanisms of punicalagin against PTC still remained to be further explored. DDR activation is a proven cause of cellular senescence, which mediates anti-tumor processes under certain circumstances. In this study, we reported that punicalagin treatment generated a senescent phenotype of BCPAP cells characterized as altered morphology, increased cell granularity and senescence-associated β-galactosidase (SA-β-Gal) staining...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29675824/lamellation-in-fibrous-dysplasia-a-clinicopathologic-study
#4
Ali Fuat Cicek, Melih Kilinc, Mukerrem Safali, Omer Gunhan
BACKGROUND: Fibrous dysplasia (FD) is a maturation defect characterized by immature woven bones and stroma. However, especially in craniofacial bones, lamellation can be seen and this is associated with the maturation. AIM: To show maturation in FD and discuss the factors that may affect the maturation. MATERIALS AND METHODS: Ninety-five FD cases were divided into three subgroups according to the lamellation percentage as Groups 1, 2 and 3 (low, moderate and high lamellation, respectively)...
April 20, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29675113/downregulation-of-bancr-promotes-aggressiveness-in-papillary-thyroid-cancer-via-the-mapk-and-pi3k-pathways
#5
Jinjun Zhang, Yaying Du, Xiaoxue Zhang, Mengchen Li, Xingrui Li
Recent evidence indicates that long non-coding RNAs play important roles in tumorigenesis and cancer progression. BRAF -activated non-protein coding RNA ( BANCR ) is a novel and potential regulator of cancer cell proliferation and migration. However, little is known regarding the role of BANCR in papillary thyroid cancer (PTC). The current study used quantitative PCR to demonstrate that BANCR was significantly downregulated in 60 paired PTC tissues compared with normal tissues. In addition, BANCR was significantly correlated with lymph node metastasis ( p = 0...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29672893/dynamic-risk-stratification-system-in-post-lobectomy-low-risk-and-intermediate-risk-papillary-thyroid-carcinoma-patients
#6
Jae Won Cho, Yu-Mi Lee, Yi Ho Lee, Suck Joon Hong, Jong Ho Yoon
OBJECTIVE: The dynamic risk stratification (DRS) and its current definition of each response-to-therapy category in post-lobectomy papillary thyroid carcinoma (PTC) patients have not been well studied. This study aimed to validate the DRS system and to investigate useful thyroglobulin (Tg) or anti-Tg antibody (Ab)-related parameters in defining each response-to-therapy category DESIGN: Retrospective observational study. PATIENTS: This historical cohort study included 619 patients with PTC treated by thyroid lobectomy...
April 19, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29672723/an-analysis-of-the-american-joint-committee-on-cancer-8th-edition-t-staging-system-for-papillary-thyroid-carcinoma
#7
Bryan Tran, David Roshan, Earl Abraham, Laura Wang, Natalia Garibotto, James Wykes, Peter Campbell, Ardalan Ebrahimi
Background: The American Joint Committee on Cancer (AJCC) removed microscopic extrathyroidal extension (m-ETE) from the 8th edition T staging for papillary thyroid carcinoma (PTC) based on increasing evidence that it is not an independent prognostic factor. Objectives: We aimed to compare the prognostic performance of AJCC 7th (pT7) and 8th (pT8) edition T stage systems, particularly in patient's ≥55 years old without macroscopic ETE or distant metastases, in whom T classification impacts TNM stage...
April 16, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29666104/bilateral-chylothorax-following-reoperative-central-neck-dissection-for-metastatic-papillary-thyroid-cancer
#8
Ashwyn K Sharma, Zeyad T Sahli, Aarti Mathur
Locoregional recurrence of papillary thyroid cancer (PTC) can occur in up to 30% of patients within 10 years after initial treatment. Reoperative surgery can be challenging due to scarring, fibrosis and distorted anatomy and may be associated with increased complications compared with initial operations. Chylothorax is an extremely rare and potentially life-threatening complication that can be associated with neck dissections and thyroid surgery. In this report, we describe an unusual case of bilateral chylothorax following a left central neck dissection for recurrent PTC...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29665129/overexpression-of-epidermal-growth-factor-receptor-and-its-downstream-effector-focal-adhesion-kinase-correlates-with-papillary-thyroid-carcinoma-progression
#9
Sonja Šelemetjev, Aleksandar Bartolome, Tijana Išić Denčić, Ilona Đorić, Ivan Paunović, Svetislav Tatić, Dubravka Cvejić
Epidermal growth factor receptor (EGFR) and its downstream effector, focal adhesion kinase (FAK), have been shown to be overexpressed frequently in human malignancies and implicated in tumour aggressiveness. We aimed to investigate the relationship between EGFR and FAK expression and their possible correlation with the clinical phenotype of patients with papillary thyroid carcinoma (PTC). Expression profiles of EGFR and FAK were analysed in PTC tissue samples (n = 104) by immunohistochemistry and Western blotting...
April 17, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29663653/the-mir-7-and-bag-of-marbles-genes-regulate-hedgehog-pathway-signaling-in-blood-cell-progenitors-in-drosophila-larval-lymph-glands
#10
Tsuyoshi Tokusumi, Yumiko Tokusumi, Robert A Schulz
Hedgehog (Hh) pathway signaling is crucial for the maintenance of blood cell progenitors in the lymph gland hematopoietic organ present in Drosophila third instar larvae. Previous studies from our lab have likewise shown the importance of the mir-7 and bag of marbles (bam) genes in maintaining the progenitor state. Thus we sought to investigate a possible interaction between the Hh pathway and mir-7/bam in the prohemocyte population within this hematopoietic tissue. Gain of function mir-7 was able to rescue a blood cell progenitor depletion phenotype caused by Patched (Ptc) inhibition of Hh pathway signaling in these cells...
April 16, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29658835/sonographic-features-of-multifocal-papillary-thyroid-carcinomas
#11
Dong Wook Kim, Gi Won Shin, Yoo Jin Lee, Soo Jin Jung, Hye Jin Baek, Taewoo Kang
OBJECTIVE: It is uncertain whether papillary thyroid carcinomas (PTCs) of the same subtype display similar sonographic features. This retrospective analysis of pre-operative sonographic and pathologic findings aimed to assess whether PTCs of the same subtype share sonographic features. METHODS: Before undergoing thyroid surgery, 137 patients underwent ultrasound (US) examination. A single radiologist used a picture archiving and communication system and pathologic reports to investigate all sonographic features of the largest and second largest PTCs...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29658205/reduced-suprathreshold-odor-identification-in-patients-with-pseudotumor-cerebri-a-non-randomized-prospective-study
#12
Gad Dotan, Eyal Cohen, Ainat Klein, Anat Kesler
BACKGROUND: Recent evidence suggests that olfaction is impaired in patients with pseudotumor cerebri (PTC). OBJECTIVES: To measure suprathreshold olfactory function by using the University of Pennsylvania Smell Identification Test (UPSIT), assessing its usefulness for routine clinical use. METHODS: Forty PTC patients underwent USPIT olfactory testing. RESULTS: Twenty-nine out of 40 (73%) PTC patients (36 women, 4 men; mean age 34 years) had reduced suprathreshold smell sensation according to UPSIT scores: 19 (47%) had mild microsmia, 9 (23%) had moderate microsmia, and one (3%) was classified as having severe microsmia...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29657135/precision-targeted-therapy-with-blu-667-for-ret-driven-cancers
#13
Vivek Subbiah, Justin F Gainor, Rami Rahal, Jason D Brubaker, Joseph L Kim, Michelle Maynard, Wei Hu, Qiongfang Cao, Michael P Sheets, Douglas Wilson, Kevin J Wilson, Lucian DiPietro, Paul Fleming, Michael Palmer, Mimi I Hu, Lori Wirth, Marcia S Brose, Sai-Hong Ignatius Ou, Matthew Taylor, Elena Garralda, Stephen Miller, Beni Wolf, Christoph Lengauer, Timothy Guzi, Erica K Evans
The receptor tyrosine kinase, rearranged during transfection (RET), is an oncogenic driver activated in multiple cancers including non-small cell lung cancer (NSCLC), medullary thyroid cancer (MTC) and papillary thyroid cancer (PTC). No approved therapies have been designed to target RET; treatment has been limited to multi-kinase inhibitors (MKIs) which can have significant off-target toxicities and limited efficacy. BLU-667 is a highly potent and selective RET inhibitor designed to overcome these limitations...
April 15, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29651624/in-papillary-thyroid-carcinoma-expression-by-immunohistochemistry-of-braf-v600e-pd-l1-and-pd-1-is-closely-related
#14
Yanhua Bai, Ting Guo, Xiaozheng Huang, Qi Wu, Dongfeng Niu, Xinqiang Ji, Qin Feng, Zhongwu Li, Kennichi Kakudo
Immune checkpoint inhibitor therapies targeting PD-L1/PD-1 have been shown to be effective in treating several types of human cancer. In papillary thyroid carcinoma (PTC), little is known about the expression of PD-L1/PD-1 in the tumor microenvironment or its potential correlation with BRAF V600E mutation status. In this study, we examined the expression of PD-L1, PD-1, and BRAF V600E in PTC by immunohistochemistry and investigated the clinical significance of expression status. We studied the expression of PD-L1, PD-1, and BRAF V600E by immunohistochemical staining in 110 cases of PTC with a diameter > 1 cm...
April 12, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29648575/early-evolutionary-divergence-between-papillary-and-anaplastic-thyroid-cancers
#15
J Capdevila, R Mayor, F F Mancuso, C Iglesias, G Caratù, I Matos, C Zafón, J Hernando, A Petit, P Nuciforo, J M Cameselle-Teijeiro, C Álvarez, J A Recio, J Tabernero, X Matias-Guiu, A Vivancos, J Seoane
Background: Papillary thyroid cancer (PTC) is the most common thyroid carcinoma and exhibits an almost uniformly good prognosis, while anaplastic thyroid cancer (ATC) is less frequent and is one of the most aggressive cancers usually resistant to conventional treatment. Current hypothesis posits that ATC derives from PTC through the progressive acquisition of a discrete number of genomic alterations and implies that the mutational landscape of ATC resembles that of PTC. However, the clinical behaviour of ATC and PTC is radically different...
April 10, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29626249/molecular-markers-in-well-differentiated-thyroid-cancer
#16
REVIEW
Anil K D'Cruz, Richa Vaish, Abhishek Vaidya, Iain J Nixon, Michelle D Williams, Vincent Vander Poorten, Fernando López, Peter Angelos, Ashok R Shaha, Avi Khafif, Alena Skalova, Alessandra Rinaldo, Jennifer L Hunt, Alfio Ferlito
PURPOSE: Thyroid nodules are of common occurrence in the general population. About a fourth of these nodules are indeterminate on aspiration cytology placing many a patient at risk of unwanted surgery. The purpose of this review is to discuss various molecular markers described to date and place their role in proper perspective. This review covers the fundamental role of the signaling pathways and genetic changes involved in thyroid carcinogenesis. The current literature on the prognostic significance of these markers is also described...
April 6, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29626148/new-insights-into-the-interplay-between-the-translation-machinery-and-nonsense-mediated-mrna-decay-factors
#17
REVIEW
Etienne Raimondeau, Joshua C Bufton, Christiane Schaffitzel
Faulty mRNAs with a premature stop codon (PTC) are recognized and degraded by nonsense-mediated mRNA decay (NMD). Recognition of a nonsense mRNA depends on translation and on the presence of NMD-enhancing or the absence of NMD-inhibiting factors in the 3'-untranslated region. Our review summarizes our current understanding of the molecular function of the conserved NMD factors UPF3B and UPF1, and of the anti-NMD factor Poly(A)-binding protein, and their interactions with ribosomes translating PTC-containing mRNAs...
April 6, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29625265/network-based-meta-analysis-in-the-identification-of-biomarkers-for-papillary-thyroid-cancer
#18
Hengqiang Zhao, Hehe Li
Papillary thyroid carcinoma (PTC) has been increasing across the world with incomplete understanding of its pathogenesis. We aimed to investigate gene alterations and biomarkers contributing to PTC development. A total of five eligible microarray datasets including 94 PTC and 81 normal thyroid samples were included to identify gene expression signatures. Using integrative meta-analysis of expression data (INMEX) program, we identified a total of 2699 differentially expressed genes (DEGs) (1333 overexpressed and 1366 underexpressed genes) in PTC relative to normal thyroid samples...
April 3, 2018: Gene
https://www.readbyqxmd.com/read/29621982/using-a-nomogram-based-on-preoperative-serum-fibrinogen-levels-to-predict-recurrence-of-papillary-thyroid-carcinoma
#19
Lei Jianyong, Li Zhihui, Gong Rixiang, Zhu Jingqiang
BACKGROUND: Hyperfibrinogenemia is increasingly being recognized as an important risk factor related to cancer stage, development and outcomes. We evaluated whether preoperative serum fibrinogen levels predict recurrence of papillary thyroid carcinoma (PTC). METHODS: We retrospectively collected data for 1023 PTC patients who underwent surgery at our institution from Aug 2014 to Aug 2016. In total, 414 patients (from Aug 2014 to Dec 2015) were used as the training set to build the model, and 609 patients (from Jan 2016 to Aug 2016) were used as the testing set to validate the model...
April 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29620212/larp7-in-papillary-thyroid-carcinoma-induces-nis-expression-through-suppression-of-the-shh-signaling-pathway
#20
Xiaomei Sui, Yana Sui, Yonghui Wang
The incidence of thyroid cancer has increased the past few decades, the most frequent type has been identified to be the papillary thyroid carcinoma (PTC). Following thyroidectomy, radioiodine ablation treatment on PTC is routinely performed. However, many patients do not benefit from radioiodine therapy. Therefore, novel targeted therapies to suppress tumor growth and improve radioiodine uptake are required. La ribonucleoprotein domain family member (LARP)7 is a member of the LARP family and functions as a potential suppressor of the progression of carcinoma...
April 5, 2018: Molecular Medicine Reports
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