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https://www.readbyqxmd.com/read/29243023/lef-1-is-a-sensitive-marker-of-cribriform-morular-variant-of-papillary-thyroid-carcinoma
#1
Shalini Mohindra, Hany Sakr, Charles Sturgis, Deborah J Chute
Cribriform morular variant of PTC (CMV-PTC) frequently shows activation of the CTNNB1/Wnt pathway with nuclear accumulation of beta catenin. The utility of LEF-1, also in the CTNNB1/WNT pathway, in the diagnosis of CMV-PTC has not been previously studied. LEF-1 immunohistochemistry was performed on seven CMV-PTC, 52 benign cases and 101 malignant thyroid neoplasms. LEF-1 was scored by stain intensity (0 = no nuclear stain, 1 = weak nuclear stain, less than lymphocyte and 2 = strong nuclear stain, intense as lymphocyte) and percentage of positive cells at each intensity, for a maximum total score of 200...
December 14, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29240898/natural-history-of-contralateral-nodules-after-lobectomy-in-patients-with-papillary-thyroid-carcinoma
#2
Amit Ritter, Gideon Bachar, Dania Hirsch, Carlos Benbassat, Orna Katz, Nadav Kochen, Talia Diker-Cohen, Amit Akirov, Ilan Shimon, Eyal Robenshtok
Background: Bilateral thyroid nodularity is considered an indication for total thyroidectomy in papillary thyroid carcinoma (PTC) patients. However, the natural history and outcome of contralateral nodules has never been studied. Objective: To investigate the natural history of non-suspicious contralateral nodules after lobectomy for PTC. Methods: We included patients who had ≥1 solid nodules (≥3mm) in the contralateral lobe prior to surgery with benign cytology, or small non suspicious nodules per ultrasound...
December 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29240540/patient-age-associated-mortality-risk-is-differentiated-by-braf-v600e-status-in-papillary-thyroid-cancer
#3
Xiaopei Shen, Guangwu Zhu, Rengyun Liu, David Viola, Rossella Elisei, Efisio Puxeddu, Laura Fugazzola, Carla Colombo, Barbara Jarzab, Agnieszka Czarniecka, Alfred K Lam, Caterina Mian, Federica Vianello, Linwah Yip, Garcilaso Riesco-Eizaguirre, Pilar Santisteban, Christine J O'Neill, Mark S Sywak, Roderick Clifton-Bligh, Bela Bendlova, Vlasta Sýkorová, Mingzhao Xing
Purpose For the past 65 years, patient age at diagnosis has been widely used as a major mortality risk factor in the risk stratification of papillary thyroid cancer (PTC), but whether this is generally applicable, particularly in patients with different BRAF genetic backgrounds, is unclear. The current study was designed to test whether patient age at diagnosis is a major mortality risk factor. Patients and Methods We conducted a comparative study of the relationship between patient age at diagnosis and PTC-specific mortality with respect to BRAF status in 2,638 patients (623 men and 2,015 women) with a median age of 46 years (interquartile range, 35 to 58 years) at diagnosis and a median follow-up time of 58 months (interquartile range, 26 to 107 months)...
December 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29239040/molecular-pathology-of-thyroid-tumours-of-follicular-cells-a-review-of-genetic-alterations-and-their-clinicopathological-relevance
#4
REVIEW
Giorgia Acquaviva, Michela Visani, Andrea Repaci, Kerry J Rhoden, Dario de Biase, Annalisa Pession, Tallini Giovanni
Thyroid cancer is the most common endocrine malignancy. Knowledge of the molecular pathology of thyroid tumours originating from follicular cells has greatly advanced in the past several years. Common molecular alterations, such as BRAF p.V600E, RAS point mutations, and fusion oncogenes (RET-PTC being the prototypical example), have been, respectively, associated with conventional papillary carcinoma, follicular-patterned tumours (follicular adenoma, follicular carcinoma, and the follicular variant of papillary carcinoma/non-invasive follicular thyroid neoplasm with papillary-like nuclear features), and with papillary carcinomas from young patients and arising after exposure to ionising radiation, respectively...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29238850/risk-factors-for-central-neck-lymph-node-metastases-in-micro-versus-macro-%C3%A2-clinically-node%C3%A2-negative-papillary-thyroid-carcinoma
#5
Luca Sessa, Celestino Pio Lombardi, Carmela De Crea, Serena Elisa Tempera, Rocco Bellantone, Marco Raffaelli
BACKGROUND: Tumor size has been advocated as possible risk factors for occult central lymph node metastases (CNM) in papillary thyroid carcinoma (PTC) patients. This prospective study evaluated factors that could identify patients at higher risk of occult CNM, especially comparing micro-PTC and macro-PTC. METHODS: One hundred and eighty-six patients were recruited. All the patients had cN0 clinically unifocal PTC and underwent total thyroidectomy and bilateral prophylactic central neck dissection...
December 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29238849/video-assisted-thyroidectomy-for-papillary-thyroid-carcinoma-oncologic-outcome-in-patients-with-follow-up%C3%A2-%C3%A2-%C3%A2-10-years
#6
Rocco Bellantone, Marco Raffaelli, Carmela De Crea, Luca Sessa, Emanuela Traini, Pietro Princi, Celestino Pio Lombardi
BACKGROUND: Video-assisted thyroidectomy (VAT) arisen as a valid treatment for selected patients with papillary thyroid carcinoma (PTC), but no data concerning long-term oncologic outcome are available. The primary aim of the study was to evaluate the oncologic outcome of patients who underwent VAT for PTC with a follow-up ≥ 10 years. METHODS: The medical charts of all the patients who successfully underwent VAT for PTC were reviewed. The patients with a minimum follow-up period of 120-months were included...
December 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29238449/the-physical-therapy-compact-from-development-to-implementation
#7
Leslie Adrian
The Federation of State Boards of Physical Therapy (FSBPT) began the process of implementing the Physical Therapy Compact (PTC) in 2010 with a delegate assembly motion. An interstate compact is an agreement between states to enact legislation and enter into a contract for a specific, limited purpose or to address a particular policy issue. An interstate compact benefits patients, consumers, and licensees by addressing workforce concerns improving licensure portability from state-to-state; facilitating short-term mobility and telehealth consultation for physical therapists...
2017: International Journal of Telerehabilitation
https://www.readbyqxmd.com/read/29234576/comparing-postdeposition-reactions-of-electrons-and-radicals-with-pt-nanostructures-created-by-focused-electron-beam-induced-deposition
#8
Julie A Spencer, Michael Barclay, Miranda J Gallagher, Robert Winkler, Ilyas Unlu, Yung-Chien Wu, Harald Plank, Lisa McElwee-White, D Howard Fairbrother
The ability of electrons and atomic hydrogen (AH) to remove residual chlorine from PtCl2 deposits created from cis-Pt(CO)2Cl2 by focused electron beam induced deposition (FEBID) is evaluated. Auger electron spectroscopy (AES) and energy-dispersive X-ray spectroscopy (EDS) measurements as well as thermodynamics calculations support the idea that electrons can remove chlorine from PtCl2 structures via an electron-stimulated desorption (ESD) process. It was found that the effectiveness of electrons to purify deposits greater than a few nanometers in height is compromised by the limited escape depth of the chloride ions generated in the purification step...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29230715/chronic-lymphocytic-thyroiditis-clt-has-a-positive-prognostic-value-in-papillary-thyroid-cancer-ptc-patients-the-potential-key-role-of-foxp3-%C3%A2-t-lymphocytes
#9
T Pilli, P Toti, R Occhini, M G Castagna, S Cantara, M Caselli, S Cardinale, L Barbagli, F Pacini
BACKGROUND: An impact of chronic lymphocytic thyroiditis (CLT) on papillary thyroid cancer (PTC) outcome has long been advocated but it is still controversial. PURPOSE: The aim of this study was to evaluate the prognostic value of CLT in a retrospective cohort of PTC patients and to characterize the lymphocytic subpopulations and infiltrate (LI). MATERIALS AND METHODS: We assessed 375 PTC patients, aged 45.2 ± 16.4 years, and treated with thyroidectomy and radioiodine remnant ablation, with a mean follow-up of 6...
December 11, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29229463/circulating-epithelial-cells-as-potential-biomarkers-for-detection-of-recurrence-in-patients-of-papillary-thyroid-carcinoma-with-positive-serum-anti-thyroglobulin-antibody
#10
Yan-Rong Li, Ching-Ping Tseng, Hsueh-Ling Hsu, Hung-Chih Lin, Yi-An Chen, Szu-Tah Chen, Miaw-Jene Liou, Jen-Der Lin
BACKGROUND: Serum thyroglobulin (Tg) is not a reliable tumor marker for monitoring disease status after treatment in patients with papillary thyroid carcinoma (PTC) with positive anti-thyroglobulin antibody (TgAb). The aim of this study was to evaluate the clinical role of circulating epithelial cells (CECs) in PTC patients with positive serum TgAb and undetectable serum Tg. METHODS: A pilot study was performed to evaluate CECs in 25 PTC patients with positive serum TgAb and undetectable serum Tg...
December 8, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29229408/imbalance-in-dna-repair-machinery-is-associated-with-brafv600e-mutation-and-tumor-aggressiveness-in-papillary-thyroid-carcinoma
#11
Bruna S Lutz, Natalia M Leguisamo, Nicole K Cabral, Helena C Gloria, Keli C Reiter, Grasiela Agnes, Virgilio Zanella, Erika L S Meyer, Jenifer Saffi
The involvement of alterations in MLH1, an essential mismatch repair component, in BRAFV600E mutated papillary thyroid carcinoma (PTC) has been suggested to be associated with features of tumor aggressiveness. Thirty-two PTC and surrounding normal thyroid tissues were evaluated for 11 representative DNA repair genes expression. BRAFV600E mutational status assessment and clinicopathological correlations were evaluated for their gene and protein expression. BRAFV600E PTC is associated with lower levels of XPD and MLH1 gene expression...
December 8, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29228842/mammary-analogue-secretory-carcinoma-of-the-thyroid-mimicking-locally-advanced-papillary-thyroid-carcinoma-a-rare-case-report
#12
Haihui Liao, Ashraf Khan, Patricia M Miron, Kristine M Cornejo
Mammary analogue secretory carcinoma (MASC) harboring ETV6 gene rearrangements was first described in the salivary gland with a relatively favorable prognosis and a possible molecular therapeutic target with pan-Trk inhibitors. Recently, primary MASC of the thyroid gland has been reported. We report a case of a 4.0 cm MASC arising from the left thyroid of a 58-year-old female with extrathyroidal extension. Initially, it was diagnosed by fine needle aspiration as suspicious for papillary thyroid carcinoma (PTC) and subsequently called a poorly differentiated carcinoma on resection...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29228620/unfavorable-efficacy-to-131i-ablation-in-brafv600e-mutant-papillary-thyroid-carcinoma-with-positive-tgab
#13
Na Zhang, Jun Liang, Yan-Song Lin
The BRAFV600E mutation has shown a close relationship of aggressiveness in papillary thyroid carcinoma (PTC), while it remains unclear about its influence on the therapeutic response. As a common clinicopathologic risk factor, thyroglobulin antibody (TgAb) may have a correlation of prognosis in PTC. The objective was to investigate the relationship between BRAFV600E mutation and TgAb, and their combined effect on efficacy to radioiodine remnant ablation (RRA). This was a retrospective study including 298 PTC patients and they were divided into four groups according to the combined status...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228520/the-significance-of-trop2-expression-in-predicting-braf-mutations-in-papillary-thyroid-carcinoma
#14
Joon Seog Kong, Hyeon Jin Kim, Min-Jung Kim, Areumnuri Kim, Dalnim Lee, Kanghee Han, Sunhoo Park, Jae Soo Koh, Jae Kyung Myung
Background: Trophoblast antigen 2 (TROP2) is a human trophoblast cell-surface glycoprotein that is overexpressed in several types of epithelial cancers, and is suggested to be associated with an unfavorable prognosis. BRAF mutations are the most common genetic alteration in papillary thyroid carcinoma (PTC). We evaluated the correlation between TROP2 expression and BRAF mutation in PTC. Methods: First, we carried out pyrosequencing for BRAF mutations and immunohistochemistry for TROP2 expression with a tissue microarray consisting of 52 PTC cases...
December 11, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29221192/tumor-suppressive-function-of-unc5d-in-papillary-thyroid-cancer
#15
Man-Man Zhang, Feng Sun, Bing Cui, Le-Le Zhang, Ya Fang, Yan Li, Rui-Jia Zhang, Xiao-Ping Ye, Yu-Ru Ma, Bing Han, Huai-Dong Song
Background: Studies have shown an association of the UNC5D gene with kidney and bladder cancer and neuroblastoma. We investigated whether UNC5D acts as a tumor suppressor in papillary thyroid carcinoma (PTC). Methods: Primary PTC tumors and matched normal thyroid tissues were obtained from 112 patients to detect UNC5D mRNA by real-time PCR. Genomic DNA sequencing was performed to detect BRAF mutation in PTC tumors. The association between UNC5D expression and clinicopathological data from PTC patients was reviewed retrospectively...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29214440/massarray-based-simultaneous-detection-of-hotspot-somatic-mutations-and-recurrent-fusion-genes-in-papillary-thyroid-carcinoma-the-ptc-ma-assay
#16
Chiara Pesenti, Marina Muzza, Carla Colombo, Maria Carla Proverbio, Claudia Farè, Stefano Ferrero, Monica Miozzo, Laura Fugazzola, Silvia Tabano
PURPOSE: We exploited the MassARRAY (MA) genotyping platform to develop the "PTC-MA assay", which allows the simultaneous detection of 13 hotspot mutations, in the BRAF, KRAS, NRAS, HRAS, TERT, AKT1, PIK3CA, and EIF1AX genes, and six recurrent genetic rearrangements, involving the RET and TRK genes in papillary thyroid cancer (PTC). METHODS: The assay was developed using DNA and cDNA from 12 frozen and 11 formalin-fixed paraffin embedded samples from 23 PTC cases, together with positive and negative controls...
December 6, 2017: Endocrine
https://www.readbyqxmd.com/read/29211863/high-serum-tsh-level-is-associated-with-progression-of-papillary-thyroid-microcarcinoma-during-active-surveillance
#17
Hye In Kim, Hye Won Jang, Hyeon Seon Ahn, Soohyun Ahn, So Young Park, Young Lyun Oh, Soo Yeon Hahn, Jung Hee Shin, Jung-Han Kim, Jee Soo Kim, Jae Hoon Chung, Tae Hyuk Kim, Sun Wook Kim
Objective: Thyroid-stimulating hormone (TSH) is a growth factor affecting initiation or progression of papillary thyroid cancer (PTC), which supports TSH suppressive therapy in PTC patients. In patients with papillary thyroid microcarcinoma (PTMC) during active surveillance, however, the association between serum TSH level and growth of PTMC has not been demonstrated. Patients: We analyzed 127 PTMCs in 126 patients under active surveillance with serial serum TSH measurement and ultrasonography...
December 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29209946/usability-and-patient-preference-phase-3-study-of-the-sarilumab-pen-in-patients-with-active-moderate-to-severe-rheumatoid-arthritis
#18
Alan Kivitz, Lydie Baret-Cormel, Hubert van Hoogstraten, Sheldon Wang, Janie Parrino, Christine Xu, Marina Stanislav
INTRODUCTION: Sarilumab is a human monoclonal antibody that blocks the interleukin-6 receptor alpha (IL-6Rα). The phase 3 SARIL-RA-EASY study (EASY) assessed the robustness of an autoinjector (pen) for administering sarilumab when used by adults with active moderate-to-severe rheumatoid arthritis (RA) who are candidates for anti-IL-6R therapy in an unsupervised real-world setting. METHODS: EASY was a 12-week, multicenter, randomized, open-label, parallel-group usability study of the sarilumab pen and prefilled syringe...
December 5, 2017: Rheumatology and Therapy
https://www.readbyqxmd.com/read/29209896/braf-oncogene-induced-senescence-and-the-role-of-thyroid-stimulating-hormone-signaling-in-the-progression-of-papillary-thyroid-carcinoma
#19
REVIEW
F I Moulana, A A H Priyani, M V C de Silva, R S Dassanayake
Oncogene-induced senescence (OIS) explains the phenomenon of cellular senescence triggered by the action of oncogenes. It is a mechanism adopted by a cell to inhibit progression of benign tumors into malignancy, occurs in premalignant lesions, and is almost never present in malignant lesions. BRAF mutations occur in about 40-45% of all papillary thyroid carcinomas (PTCs) and of which 99.7% is the BRAFV600E mutation. A unique phenotype of the BRAFV600E mutation is the upregulation of the thyroid-stimulating hormone receptor (TSHR) on thyrocyte membranes...
December 5, 2017: Hormones & Cancer
https://www.readbyqxmd.com/read/29208708/aminoglycoside-interactions-and-impacts-on-the-eukaryotic-ribosome
#20
Irina Prokhorova, Roger B Altman, Muminjon Djumagulov, Jaya P Shrestha, Alexandre Urzhumtsev, Angelica Ferguson, Cheng-Wei Tom Chang, Marat Yusupov, Scott C Blanchard, Gulnara Yusupova
Aminoglycosides are chemically diverse, broad-spectrum antibiotics that target functional centers within the bacterial ribosome to impact all four principle stages (initiation, elongation, termination, and recycling) of the translation mechanism. The propensity of aminoglycosides to induce miscoding errors that suppress the termination of protein synthesis supports their potential as therapeutic interventions in human diseases associated with premature termination codons (PTCs). However, the sites of interaction of aminoglycosides with the eukaryotic ribosome and their modes of action in eukaryotic translation remain largely unexplored...
December 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
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