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https://www.readbyqxmd.com/read/27896927/a-retrospective-review-of-anesthesia-and-perioperative-care-in-children-with-medium-chain-acyl-coa-dehydrogenase-deficiency
#1
Claire Allen, Russell Perkins, Bernd Schwahn
BACKGROUND: Medium-chain acyl-CoA dehydrogenase deficiency is the most common genetically determined disorder of mitochondrial fatty acid oxidation. Decompensation can result in hypoglycemia, seizures, coma, and death but may be prevented by ensuring glycogen stores do not become depleted. Perioperative care is of interest as surgery, fasting, and infection may all trigger decompensation and the safety of anesthetic agents has been questioned. Current guidelines from the British Inherited Metabolic Disease Group advise on administering fluid containing 10% glucose during the perioperative period...
November 29, 2016: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27869199/ion-mobility-spectrometry-as-a-simple-and-rapid-method-to-measure-the-plasma-propofol-concentrations-for-intravenous-anaesthesia-monitoring
#2
Xin Wang, Qinghua Zhou, Dandan Jiang, Yulei Gong, Enyou Li, Haiyang Li
The plasma propofol concentration is important information for anaesthetists to monitor and adjust the anaesthesia depth for patients during a surgery operation. In this paper, a stand-alone ion mobility spectrometer (IMS) was constructed for the rapid measurement of the plasma propofol concentrations. Without any sample pre-treatment, the plasma samples were dropped on a piece of glass microfiber paper and then introduced into the IMS cell by the thermal desorption directly. Each individual measurement could be accomplished within 1 min...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27729798/identifying-candidate-agents-for-lung-adenocarcinoma-by-walking-the-human-interactome
#3
Yajiao Sun, Ranran Zhang, Zhe Jiang, Rongyao Xia, Jingwen Zhang, Jing Liu, Fuhui Chen
Despite recent advances in therapeutic strategies for lung cancer, mortality is still increasing. Therefore, there is an urgent need to identify effective novel drugs. In the present study, we implement drug repositioning for lung adenocarcinoma (LUAD) by a bioinformatics method followed by experimental validation. We first identified differentially expressed genes between LUAD tissues and nontumor tissues from RNA sequencing data obtained from The Cancer Genome Atlas database. Then, candidate small molecular drugs were ranked according to the effect of their targets on differentially expressed genes of LUAD by a random walk with restart algorithm in protein-protein interaction networks...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27703286/a-comparison-between-the-hemodynamic-effects-of-cisatracurium-and-atracurium-in-patient-with-low-function-of-left-ventricle-who-are-candidate-for-open-heart-surgery
#4
Masoud Ghorbanlo, Mahmoud Reza Mohaghegh, Forozan Yazdanian, Mehrdad Mesbah, Ziya Totonchi
BACKGROUND: The need for muscle relaxants in general anesthesia in different surgeries including cardiac surgeries, and the type of relaxant to be used considering its different hemodynamic effects on patients with heart disease can be of considerable importance. In this study, the hemodynamic effects of two muscle relaxants, Cisatracurium and Atracurium in patients whit low function of left ventricle who are candidate for open heart surgery have been considered. METHOD: This study has been designed as a randomized prospective double-blind clinical trial...
July 27, 2016: Medical Archives
https://www.readbyqxmd.com/read/27698008/phlebitis-as-a-consequence-of-peripheral-intravenous-administration-of-cisatracurium-besylate-in-critically-ill-patients
#5
Annelijn M Meeder, Marijke S van der Steen, Annemieke Rozendaal, Arthur R H van Zanten
This case report series describes 3 cases of cisatracurium besylate associated phlebitis after an infusion period of 14-20 hours. No similar cases have been reported in the literature. Association of phlebitis with another neuromuscular blocking agent, atracurium, has been described in the literature. The acidity of atracurium is thought to be the main cause. It is recommended that atracurium is administered only via central venous catheters when indicated to infuse over prolonged periods of time due to the acidity...
October 3, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27648185/the-effect-of-intravenous-magnesium-sulfate-infusion-on-reduction-of-pain-after-abdominal-hysterectomy-under-general-anesthesia-a-double-blind-randomized-clinical-trial
#6
Mohammad Hossein Jarahzadeh, Sina Taghizadeh Harati, Hamideh Babaeizadeh, Elahe Yasaei, Farshid Rahimi Bashar
BACKGROUND: Post-surgical pain is a physiological response to tissue trauma that produces unpleasant physiological effects with manifestations on various organic systems. OBJECTIVE: According to the effect of magnesium sulfate on the N-methyl-d-aspartate (NMDA) receptor, this study examined the effect of magnesium sulfate on the reduction of pain and the mean amount of narcotics consumed by patients after abdominal hysterectomies. METHODS: This double-blind clinical trial study was performed on 60 patients who had undergone abdominal hysterectomies in Shahid Sadoughi Hospital in Yazd, Iran, from 2013 to 2015...
July 2016: Electronic Physician
https://www.readbyqxmd.com/read/27501607/anesthetic-management-for-esophageal-stent-placement-in-an-endoscopy-unit-outside-operating-room
#7
Somchai Amornyotin, Sukanya Jirachaipitak, Surasawadee Wangnamtip
BACKGROUND: Esophageal stent placement is a minimally invasive procedure for treatment of esophageal strictures that cannot be treated with surgical procedure. It requires some forms of anesthesia. This procedure could be performed in the operating room and in the endoscopy unit. OBJECTIVE: The study is aimed to report and evaluate the choices and techniques, drugs used and complications of anesthesia in the patients undergoing esophageal stent placement procedure in an endoscopy unit outside the operating room in a developing country...
May 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27382330/neuromuscular-blockade-in-the-elderly-patient
#8
REVIEW
Luis A Lee, Vassilis Athanassoglou, Jaideep J Pandit
Neuromuscular blockade is a desirable or even essential component of general anesthesia for major surgical operations. As the population continues to age, and more operations are conducted in the elderly, due consideration must be given to neuromuscular blockade in these patients to avoid possible complications. This review considers the pharmacokinetics and pharmacodynamics of neuromuscular blockade that may be altered in the elderly. Compartment distribution, metabolism, and excretion of drugs may vary due to age-related changes in physiology, altering the duration of action with a need for reduced dosage (eg, aminosteroids)...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27376983/quantification-of-specific-ige-antibodies-in-immediate-drug-hypersensitivity-more-shortcomings-than-potentials
#9
REVIEW
I I Decuyper, D G Ebo, A P Uyttebroek, M M Hagendorens, M A Faber, C H Bridts, L S De Clerck, V Sabato
BACKGROUND: For many physicians, quantification of serum drug-specific IgE (sIgE) antibodies constitutes the first measure in the diagnostic approach of immediate drug hypersensitivity reactions (IDHR). AIM: To review the accuracy and limitations of the main drug-sIgE tests, especially those that are commercially available. METHODS: A literature search was conducted, using the key-words allergy, diagnosis, drugs, hypersensitivity, specific IgE antibodies; this was complemented by the authors' own experience...
September 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27247914/comparing-clonidine-and-lidocaine-on-attenuation-of-hemodynamic-responses-to-laryngoscopy-and-tracheal-intubation-in-controlled-hypertensive-patients-a-randomized-double-blinded-clinical-trial
#10
Sussan Soltani Mohammadi, Alireza Maziar, Alireza Saliminia
BACKGROUND: Hemodynamic fluctuations in response to laryngoscopy and tracheal intubation and their potential hazards have been well-recognized, especially in hypertensive patients. Many drugs in various combinations have been used to attenuate these adverse responses. OBJECTIVES: We conducted a study to compare lidocaine with clonidine on the attenuation of hemodynamic responses to laryngoscopy and tracheal intubation, in controlled hypertensive patients undergoing general anesthesia...
April 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/27168088/do-we-really-need-sugammadex-as-an-antagonist-of-muscle-relaxants-in-anesthesia
#11
Claude Meistelman, François Donati
PURPOSE OF REVIEW: Sugammadex is a selective relaxant-binding agent that is designed to encapsulate rocuronium and chemically similar steroidal muscle relaxants such as vecuronium. This review summarizes recent information on the use of sugammadex in clinical practice. RECENT FINDINGS: The main advantages of sugammadex when compared with conventional anticholinesterase agents are a much faster recovery time and its unique ability to reverse rapidly and efficiently, for the first time, deep levels of neuromuscular blockade...
August 2016: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/27141626/-effect-of-subcutaneous-injection-of-lidocaine-in-zusanli-st-36-and-jiaji-ex-b-2-regions-on-immune-function-in-patients-undergoing-laparoscopic-cholecystectomy
#12
RANDOMIZED CONTROLLED TRIAL
Xin-liang Meng, Qiang Qu
OBJECTIVE: To observe the effect of acupoint injection of Lidocaine on serum IL-1β, TNF-α and T-lymphocyte subset activities in patients undergoing laparoscopic cholecystectomy (LC), so as to reveal its mechanisms underlying relieving postoperative pain and potentiating rehabilitation. METHODS: Eighty patients scheduled for elective LC surgery (grade I or II, according to American Standards of Association, ASA) were randomly divided into four groups, namely intravenous analgesia (IVA) , right forearm-injection (forearm-), Jiaji (EX-B 2, Thorax 8)-injection (EX-B 2-1), and Zusanli-injection (ST 36-1), with 20 patients in each group...
February 2016: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/27131419/under-sevoflurane-anaesthesia-a-reduced-dose-of-neostigmine-can-antagonize-a-shallow-neuromuscular-block-a-double-blind-randomised-study
#13
Alice Preault, Florent Capron, Céline Chantereau, François Donati, Jérôme Dimet
BACKGROUND: It has been demonstrated that small doses of neostigmine (10-30μg.kg(-1)) effectively antagonize atracurium blocks at a train-of-four (TOF) ratio of 0.4 under propofol anaesthesia. The results might not be valid with halogenated agents, which potentiate neuromuscular blockades. The goal of this study was to determine the dose of neostigmine required to antagonize a block corresponding to a TOF ratio of 0.4, a level at which fade is not visually detected. METHODS: Sixty patients were included and anaesthesia was induced with propofol, remifentanil and cisatracurium, and maintained with sevoflurane and remifentanil...
August 2016: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/27110105/weight-based-dosing-in-medication-use-what-should-we-know
#14
REVIEW
Sheng-Dong Pan, Ling-Ling Zhu, Meng Chen, Ping Xia, Quan Zhou
BACKGROUND: Weight-based dosing strategy is still challenging due to poor awareness and adherence. It is necessary to let clinicians know of the latest developments in this respect and the correct circumstances in which weight-based dosing is of clinical relevance. METHODS: A literature search was conducted using PubMed. RESULTS: Clinical indications, physiological factors, and types of medication may determine the applicability of weight-based dosing...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/26962254/a-prospective-comparative-randomised-double-blind-study-on-the-efficacy-of-addition-of-clonidine-to-0-25-bupivacaine-in-scalp-block-for-supratentorial-craniotomies
#15
Anjana Sagar Wajekar, Shrikanta P Oak, Anita N Shetty, Ruchi A Jain
BACKGROUND AND AIMS: Scalp blocks combined with general anaesthesia reduce pin and incision response, along with providing stable perioperative haemodynamics and analgesia. Clonidine has proved to be a valuable additive in infiltrative blocks. We studied the efficacy and safety of addition of clonidine 2 μg/kg to scalp block with 0.25% bupivacaine (Group B) versus plain 0.25% bupivacaine (Group A) for supratentorial craniotomies. METHODS: Sixty patients were randomly divided into two groups to receive scalp block: Group A (with 0...
January 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/26894591/sugammadex-at-both-high-and-low-doses-does-not-affect-the-depth-of-anesthesia-or-hemodynamics-a-randomized-double-blind-trial
#16
Argyro Fassoulaki, Konstantinos Chondrogiannis, Chryssoula Staikou
Previous studies have shown that sugammadex decreases the anesthetic depth when administered to reverse the neuromuscular blockade produced by rocuronium/vecuronium. The aim of the present study was to investigate the effect of sugammadex alone on anesthetic depth and hemodynamics. Sixty patients scheduled for abdominal surgery participated in the study. Anesthesia was induced with thiopental/fentanyl and maintained with N2O/oxygen and sevoflurane concentrations adjusted to maintain Entropy and Bispectral Index (BIS) values between 40 and 50...
February 19, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/26803037/recommendations-and-low-technology-safety-solutions-following-neuromuscular-blocking-agent-incidents
#17
Linda V Graudins, Glenn Downey, Thuy Bui, Michael J Dooley
BACKGROUND: Neuromuscular blocking agents (NMBs) are high-risk medications used to facilitate endotracheal intubation and artificial ventilation. In an incident at a metropolitan tertiary referral and teaching public hospital in Australia, a neurosurgical patient became unresponsive at the start of surgery. It was determined that cisatracurium was administered in error in place of midazolam; the patient was ventilated and the emergency surgery continued. Two additional non-operating room (OR) drug-swap cases involving cisatracurium were reported within 12 months of this event, resulting in a comprehensive review of NMB safety...
February 2016: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/26655708/-reducing-sore-throat-following-laryngeal-mask-airway-insertion-comparing-lidocaine-gel-saline-and-washing-mouth-with-the-control-group
#18
Mehryar Taghavi Gilani, Iman Miri Soleimani, Majid Razavi, Maryam Salehi
BACKGROUND: Laryngeal mask airway is still accompanied by complications such as sore throat. In this study, effects of three methods of reducing postoperative sore throat were compared with the control group. METHODS: 240 patients with ASA I, II candidates for cataract surgery were randomly divided into four same groups. No supplementary method was used in the control group. In the second, third and fourth groups, lidocaine gel, washing cuff before insertion, and washing mouth before removing laryngeal mask airway were applied, respectively...
November 2015: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/26615516/esmolol-reduces-anesthetic-requirements-thereby-facilitating-early-extubation-a-prospective-controlled-study-in-patients-undergoing-intracranial-surgery
#19
RANDOMIZED CONTROLLED TRIAL
Irene Asouhidou, Anastasia Trikoupi
BACKGROUND: Adequate cerebral perfusion pressure with quick and smooth emergence from anesthesia is a major concern of the neuroanesthesiologist. Anesthesia techniques that minimize anesthetic requirements and their effects may be beneficial. Esmolol, a short acting hyperselective β-adrenergic blocker is effective in blunting adrenergic response to several perioperative stimuli and so it might interfere in the effect of the anesthetic drugs on the brain. This study was designed to investigate the effect of esmolol on the consumption of propofol and sevoflurane in patients undergoing craniotomy...
November 28, 2015: BMC Anesthesiology
https://www.readbyqxmd.com/read/26614140/reducing-sore-throat-following-laryngeal-mask-airway-insertion-comparing-lidocaine-gel-saline-and-washing-mouth-with-the-control-group
#20
Mehryar Taghavi Gilani, Iman Miri Soleimani, Majid Razavi, Maryam Salehi
BACKGROUND: Laryngeal mask airway is still accompanied by complications such as sore throat. In this study, effects of three methods of reducing postoperative sore throat were compared with the control group. METHODS: 240 patients with ASA I, II candidates for cataract surgery were randomly divided into four same groups. No supplementary method was used in the control group. In the second, third and fourth groups, lidocaine gel, washing cuff before insertion, and washing mouth before removing laryngeal mask airway were applied, respectively...
November 2015: Brazilian Journal of Anesthesiology
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