Jyotsna Reddy, Narayan Shivapurkar, Takao Takahashi, Gunjan Parikh, Victor Stastny, Chinyere Echebiri, Katherine Crumrine, Sabine Zöchbauer-Müller, Johannes Drach, Yingye Zheng, Ziding Feng, Steven H Kroft, Robert W McKenna, Adi F Gazdar
The perturbations of the cytokine signaling pathway play an important role in lymphoid/hematopoietic tumors. Aberrant promoter methylation is the major mechanism of gene silencing in tumors. We examined 150 lymphoid/hematopoietic tumors or potential premalignant specimens, 55 control specimens and 12 EBV-transformed B lymphoblastoid cultures and 10 lymphoma/leukemia (L/L) or multiple myeloma (MM) cell lines for the methylation (and, in cell lines, of the expression status) of three genes involved in the cytokine signaling pathway...
January 20, 2005: Oncogene