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Karin A L Müller, Tobias Geisler
Acute coronary syndromes (ACS) are triggered by enhanced platelet activation and aggregation. Hence, a cornerstone of successful secondary prevention in ACS is an effective platelet inhibition. Additionally, coronary interventions (PCI) lead to even increased artherothrombotic risks, another challenge in preventing recurrent events including stent thrombosis. Promising platelet targets were characterized and novel molecules were developed that are currently under investigation. Intensified antiplatelet therapy includes the risk of major bleeding which itself increases the mortality rate...
September 2012: Current Vascular Pharmacology
Charmi Shah, Guang Yang, Ian Lee, Jacek Bielawski, Yusuf A Hannun, Fahumiya Samad
Obesity increases the risk for metabolic and cardiovascular disease, and adipose tissue plays a central role in this process. Ceramide, the key intermediate of sphingolipid metabolism, also contributes to obesity-related disorders. We show that a high fat diet increased ceramide levels in the adipose tissues and plasma in C57BL/6J mice via a mechanism that involves an increase in gene expression of enzymes mediating ceramide generation through the de novo pathway (e.g. serine palmitoyltransferase) and via the hydrolysis of sphingomyelin (acid sphingomyelinase and neutral sphingomyelinase)...
May 16, 2008: Journal of Biological Chemistry
Dan James Fintel
Cardiovascular disease is prevalent among patients with stroke; thus, cardiologists frequently treat patients at high risk for stroke. Results from recent clinical trials of antiplatelet medications, given alone or in combination, may be of special interest to cardiologists. The MATCH study demonstrated no significant difference between clopidogrel alone and clopidogrel plus aspirin in reducing risk of vascular events after stroke or transient ischemic attack. A 1.3% increased risk of major bleeding was associated with clopidogrel plus aspirin...
December 2007: Clinical Cardiology
W Lepper, M Kelm
Antiplatelet therapy is used to prevent thromboembolic complications in patients with artherothrombotic disease. In clinical routine an assessment of the risk of perioperative bleeding must be weighed against the risk of thromboembolic complications in the event of discontinuation of antiplatelet agents. The indications as well as the timepoint for the termination of antiplatelet therapy are important issues to consider. The premature interruption of oral antiplatelet therapy with recovery of platelet function may lead to recurrence of thromboembolic events...
June 2007: Der Anaesthesist
Mariana Vargas Furtado, Carisi Anne Polanczyk
Diabetes mellitus is a condition associated with cardiac complications, especially artherothrombotic disease. Several studies have demonstrated the importance of reducing cardiovascular burden on this population by adopting prevention strategies. This article revised clinical evidences on cardiovascular risk assessment and prevention actions, taking into consideration major recommendations in the field. Life-style changes with low-carbohydrate diet, weight control, and regular physical activity must be implemented...
March 2007: Arquivos Brasileiros de Endocrinologia e Metabologia
Jung Yong Ahn, In Bo Han, Sang Sup Chung, Young Sun Chung, Sang Heum Kim, Pyeong Ho Yoon
Intra-arterial thrombolysis and percutaneous angioplasty is feasible in patients with acute middle cerebral artery (MCA) occlusion limited to 6 hours post-ictus, but there are some limitations such as reocclusion or hemorrhagic complications. In this report, we describe a stent placement in the treatment of a refractory artherothrombotic MCA occlusion beyond 6 hours of symptom onset. A 57-year-old man presented with a progressive left-sided weakness and verbal disturbance resulting from an acute thrombotic occlusion of the right MCA superimposed on severe proximal atheromatous stenosis...
December 2006: Neurological Research
A J Moreno-Rojas, J R González-Marcos, A Gil-Peralta, V Serrano-Castro
INTRODUCTION: Arteriosclerosis is the commonest aetiology of vertebro-basilar ischemia (VBI). In the literature few studies mention the risk profile of cerebrovascular accidents at this site. MATERIAL AND METHODS: In order to establish whether this profile has specific characteristics, we carried out a transversal study of 70 patients with VBI of artherothrombotic origin situated in the brain stem or cerebellum, determining the prevalence of the main risk factors (RF)...
January 1998: Revista de Neurologia
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