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CyBorD neuropathy

N Areethamsirikul, E Masih-Khan, C-M Chu, V Jimenez-Zepeda, D E Reece, S Trudel, V Kukreti, R Tiedemann, C Chen
Cyclophosphamide, bortezomib and dexamethasone (CyBorD) is a highly active three-drug induction regimen for untreated transplant-eligible multiple myeloma patients. Although CyBorD has been evaluated only in the phase 2 setting in a limited number of patients, its high efficacy and ease of administration have led to its widespread use. Given that clinical trial efficacy can overestimate real-life effectiveness, we reviewed our institutional experience with 109 newly diagnosed patients who were treated with CyBorD in a non-clinical trial setting...
March 2015: Bone Marrow Transplantation
Gunjan Shah, Esha Kaul, Shelly Fallo, Furha Cossor, Hedy Smith, Kellie Sprague, Andreas Klein, Kenneth Miller, Raymond Comenzo
BACKGROUND: Bortezomib is a first-in-class proteasome inhibitor approved by the US Food and Drug Administration for the treatment of all phases of multiple myeloma (MM) and it is also used for the treatment of [corrected] light-chain amyloidosis (AL). The subcutaneous formulation of bortezomib was approved in 2012 based on data from Phase III studies in patients with relapsed MM. OBJECTIVE: This article reports experience with subcutaneous bortezomib in patients with newly diagnosed MM or AL in a tertiary care center...
October 2013: Clinical Therapeutics
Rahma Warsame, Ingrid E Kohut, Angela Dispenzieri
POEMS syndrome is a rare paraneoplastic condition related to myeloma. Because it is rare, there is very little known about treatment options. The use of potentially neurotoxic chemotherapeutic drugs is of concern in a disease whose major manifestation is neuropathy. Herein, we describe an extraordinary response to the combination of cyclophosphamide, bortezomib, and dexamethasone (CyBorD) in a patient with relapsed, life-threatening POEMS syndrome.
June 2012: European Journal of Haematology
Meaghan L Khan, Craig B Reeder, Shaji K Kumar, Marthy Q Lacy, Donna E Reece, Angela Dispenzieri, Morie A Gertz, Phillip Greipp, Suzanne Hayman, Steven Zeldenhurst, David Dingli, John Lust, Stephen Russell, Kristina M Laumann, Joseph R Mikhael, P Leif Bergsagel, Rafael Fonseca, S Vincent Rajkumar, A Keith Stewart
Novel agents are considered standard components of induction therapy for newly diagnosed patients with multiple myeloma. We retrospectively compared the results of three consecutive phase 2 clinical trials; RD (lenalidomide/dexamethasone, n=34), CRD (cyclophosphamide/lenalidomide/dexamethasone, n=53) and CyBorD (cyclophosphamide/bortezomib/dexamethasone, n=63) (N=150). Response rates after four cycles of treatment were: ≥near complete response (nCR), 12% vs. 2% vs. 41%, P<0·0001 and very good partial response or better, 35% vs...
February 2012: British Journal of Haematology
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