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https://www.readbyqxmd.com/read/28806198/pre-treatment-integrase-strand-transfer-inhibitor-resistance-in-north-carolina-from-2010-2016
#1
Timothy W Menza, Rachael Billock, Erika Samoff, Joseph J Eron, Ann M Dennis
OBJECTIVE: We sought to define the prevalence of pre-treatment INSTI resistance and assess the transmission networks of those with pre-treatment INSTI resistance. DESIGN: A retrospective cohort study of HIV-positive patients with genotypic resistance testing sent to a single referral laboratory in North Carolina between 2010 and 2016. METHODS: We linked genotype and public health data for in-care HIV-positive individuals to determine the prevalence of INSTI resistance among treatment-naïve (defined as those with a first genotype ≤3 months after diagnosis) and treatment-experienced (defined as those with a first genotype >3 months after diagnosis) patients...
August 12, 2017: AIDS
https://www.readbyqxmd.com/read/28802274/horizontal-dissemination-of-antimicrobial-resistance-determinants-in-multiple-salmonella-serotypes-following-isolation-from-the-environment-of-commercial-swine-operations-after-manure-application
#2
Suchawan Pornsukarom, Siddhartha Thakur
The aim of this study was to characterize the plasmids carrying antimicrobial resistance (AMR) determinants in multiple Salmonella serotypes recovered from the commercial swine farms environment after manure application on land. Manure and soil samples were collected on day0 before and after manure application on six farms in North Carolina and sequential soil samples were recollected on day7, 14, and 21 from the same plots. All environmental samples were processed for Salmonella and their plasmid contents were further characterized...
August 11, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28801917/attention-deficit-hyperactivity-disorder-adhd-interaction-between-socioeconomic-status-and-parental-history-of-adhd-determines-prevalence
#3
Andrew S Rowland, Betty J Skipper, David L Rabiner, Fares Qeadan, Richard A Campbell, A Jack Naftel, David M Umbach
BACKGROUND: Many studies have reported a higher prevalence of Attention-Deficit/Hyperactivity Disorder (ADHD) among disadvantaged populations, but few have considered how parental history of ADHD might modify that relationship. We evaluated whether the prevalence of ADHD varies by socioeconomic status (SES) and parental history of ADHD in a population-sample of elementary school children age 6-14 years. METHODS: We screened all children in grades 1-5 in 17 schools in one North Carolina (U...
August 12, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28795860/access-to-palliative-care-consultation-and-advance-care-planning-for-adults-with-high-risk-leukemia
#4
Ashley T Freeman, William A Wood, Alexandra Fox, Laura C Hanson
BACKGROUND: Although strong evidence supports early palliative care (PC) and consistent advance care planning (ACP) for patients with poor-prognosis Stage IV solid tumors, best practice standards have not been established for hematologic malignancies. Our primary objective was to describe current access to specialty PC consultation and ACP for inpatients with high-risk leukemia. Secondary objectives were to describe components of ACP and PC practices. METHODS: We enrolled all patients with high-risk leukemia (acute leukemia ≥65 years or relapsed leukemia >18 years) admitted to the University of North Carolina Cancer Hospital from October 1, 2015, to August 1, 2016...
August 10, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28792964/turtle-soup-prohibition-and-the-population-genetic-structure-of-diamondback-terrapins-malaclemys-terrapin
#5
Paul E Converse, Shawn R Kuchta, J Susanne Hauswaldt, Willem M Roosenburg
Diamondback terrapins (Malaclemys terrapin) were a popular food item in early twentieth century America, and were consumed in soup with sherry. Intense market demand for terrapin meat resulted in population declines, notably along the Atlantic seaboard. Efforts to supply terrapins to markets resulted in translocation events, as individuals were moved about to stock terrapin farms. However, in 1920 the market for turtle soup buckled with the enactment of the eighteenth amendment to the United States' Constitution-which initiated the prohibition of alcoholic drinks-and many terrapin fisheries dumped their stocks into local waters...
2017: PloS One
https://www.readbyqxmd.com/read/28791691/birth-rates-after-radioactive-iodine-treatment-for-differentiated-thyroid-cancer
#6
Chelsea Anderson, Stephanie M Engel, Mark A Weaver, Jose P Zevallos, Hazel B Nichols
Treatment with radioactive iodine (RAI) for differentiated thyroid cancer has been associated with alterations in gonadal function in women, including changes in menstrual function and an earlier age at menopause. Our objective was to evaluate associations between RAI and post-diagnosis live birth rates among thyroid cancer survivors diagnosed at ages 15-39 years. We identified women diagnosed with differentiated thyroid cancer between January 2000 and December 2013 in the North Carolina Central Cancer Registry (CCR)...
August 9, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28790370/duplication-events-downstream-of-irx1-cause-north-carolina-macular-dystrophy-at-the-mcdr3-locus
#7
Valentina Cipriani, Raquel S Silva, Gavin Arno, Nikolas Pontikos, Ambreen Kalhoro, Sandra Valeina, Inna Inashkina, Mareta Audere, Katrina Rutka, Bernard Puech, Michel Michaelides, Veronica van Heyningen, Baiba Lace, Andrew R Webster, Anthony T Moore
Autosomal dominant North Carolina macular dystrophy (NCMD) is believed to represent a failure of macular development. The disorder has been linked to two loci, MCDR1 (chromosome 6q16) and MCDR3 (chromosome 5p15-p13). Recently, non-coding variants upstream of PRDM13 (MCDR1) and a duplication including IRX1 (MCDR3) have been identified. However, the underlying disease-causing mechanism remains uncertain. Through a combination of sequencing studies on eighteen NCMD families, we report two novel overlapping duplications at the MCDR3 locus, in a gene desert downstream of IRX1 and upstream of ADAMTS16...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28783817/associations-between-midlife-vascular-risk-factors-and-25-year-incident-dementia-in-the-atherosclerosis-risk-in-communities-aric-cohort
#8
Rebecca F Gottesman, Marilyn S Albert, Alvaro Alonso, Laura H Coker, Josef Coresh, Sonia M Davis, Jennifer A Deal, Guy M McKhann, Thomas H Mosley, A Richey Sharrett, Andrea L C Schneider, B Gwen Windham, Lisa M Wruck, David S Knopman
Importance: Vascular risk factors have been associated with cognitive decline. Midlife exposure to these factors may be most important in conferring late-life risk of cognitive impairment. Objectives: To examine Atherosclerosis Risk in Communities (ARIC) participants in midlife and to explore associations between midlife vascular risk factors and 25-year dementia incidence. Design, Setting, and Participants: This prospective cohort investigation of the Atherosclerosis Risk in Communities (ARIC) Study was conducted from 1987-1989 through 2011-2013...
August 7, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28783438/sarcocystis-strixi-n-sp-from-a-barred-owl-strix-varia-definitive-host-and-interferon-gamma-gene-knockout-mice-as-experimental-intermediate-host
#9
Shiv Verma, Alexa Rosypal, Jospeph Mowery, David Scott, Camila Cezar, Benjamin M Rosenthal, J P Dubey, David Lindsay
Here we report a new species of Sarcocystis with Barred owls as the natural definitive host and interferon gamma gene knockout (KO) mice as an experimental intermediate host. A Barred owl submitted to the Carolina Raptor Center, Huntersville, North Carolina, was euthanized because of paralysis. Fully sporulated 12.5 x 9.9 m sporocysts were found in intestinal scrapings from the owl. Sporocysts from the Barred owl were orally fed to 4 laboratories reared outbred Swiss Webster (SW) (Mus musculus) and 8 KO mice...
August 7, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28777520/factors-influencing-adherence-to-pre-dive-checklists-among-recreational-scuba-divers
#10
Shabbar I Ranapurwala, Charles Poole, Stephen W Marshall, Kristen L Kucera, Petar J Denoble, Steve Wing
Pre-dive checklists can prevent mishaps, injuries, and deaths in recreational scuba diving. However, the prevalence of checklist use remains low. Understanding the environmental and individual factors influencing a diver's checklist use may help in promoting checklists. In the summer of 2012, 617 divers were enrolled in the intervention group of a cluster randomized trial. The divers received an intervention pre-dive checklist to use before they made dives. Logistic regression analyses were used to model adherence to pre-dive checklist with generalized estimating equations...
November 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28776903/robert%C3%A2-g-parr-1921-2017
#11
Paul Ayers, Weitao Yang
Robert G. Parr, emeritus professor at the University of North Carolina at Chapel Hill, passed away at the age of 95 on March 27, 2017. Parr was one of the founders of quantum chemistry, and his seminal contributions to the field included ab initio methods, semiempirical techniques, molecular spectroscopy, and density functional theory.
August 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28776478/start-using-a-checklist-pronto-recommendation-for-a-standard-review-process-for-chemotherapy-orders
#12
Brian C Crandell, Jill S Bates, Tatjana Grgic
Chemotherapy order review by pharmacists requires careful attention to many details, and serious consequences can occur if errors are made. Other high-risk industries have long used checklists to improve accuracy and reduce the risk of errors. Despite the recent expansion of checklist use in other areas of medicine, there is currently no published evidence that checklists are being widely used by pharmacists in the evaluation of chemotherapy orders. This article explains a flexible checklist called PRONTO (Patient, Regimen, Organ Function, Numbers, Toxicity, Order Verification) that has been successfully used by pharmacists in variety of practice settings in two academic centers in North Carolina...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28766872/population-based-case-control-study-of-the-association-between-weather-related-extreme-heat-events-and-neural-tube-defects
#13
Aida Soim, Shao Lin, Scott C Sheridan, Syni-An Hwang, Wan-Hsiang Hsu, Thomas J Luben, Gary M Shaw, Marcia L Feldkamp, Paul A Romitti, Jennita Reefhuis, Peter H Langlois, Marilyn L Browne
BACKGROUND: Elevated body core temperature has been shown to have teratogenic effects in animal studies. Our study evaluated the association between weather-related extreme heat events (EHEs) in the summer season and neural tube defects (NTDs), and further investigated whether pregnant women with a high pregestational body mass index (BMI) have a greater risk of having a child with NTDs associated with exposure to EHE than women with a normal BMI. METHODS: We conducted a population-based case-control study among mothers of infants with NTDs and mothers of infants without major birth defects, who participated in the National Birth Defects Prevention Study and had at least 1 day of the third or fourth week postconception during summer months...
August 2, 2017: Birth defects research
https://www.readbyqxmd.com/read/28763570/iron-and-manganese-in-groundwater-using-kriging-and-gis-to-locate-high-concentrations-in-buncombe-county-north-carolina
#14
Crystal D Johnson, Arpita Nandi, T Andrew Joyner, Ingrid Luffman
For health, economic, and aesthetic reasons, allowable concentrations (as suggested by the United States Environmental Protection Agency) of the secondary contaminants iron (Fe) and manganese (Mn) found present in drinking water are 0.3 and 0.05 mg/L, respectively. Water samples taken from private drinking wells in rural communities within Buncombe County, North Carolina contain concentrations of these metals that exceed secondary water quality criteria. This study predicted the spatial distribution of Fe and Mn in the county, and evaluated the effect of site environmental factors (bedrock geology, ground elevation, saprolite thickness, and drinking water well depth) in controlling the variability of Fe and Mn in groundwater...
August 1, 2017: Ground Water
https://www.readbyqxmd.com/read/28760639/the-association-between-glaucoma-anxiety-and-depression-in-a-large-population
#15
Xinxin Zhang, Daniel James Olson, Patrick Le, Feng-Chang Lin, David Fleischman, Richard Marc Davis
PURPOSE: To investigate the association between glaucoma and each of anxiety and depression. DESIGN: Retrospective case-control study. METHODS: Settings: University of North Carolina hospitals and outpatient clinics. STUDY POPULATION: All patients over the age of 18 years seen between July 1, 2008 and October 1, 2015 were included. OBSERVATION PROCEDURE: International classification of disease codes were used to identify cases of glaucoma, as well as anxiety and depression...
July 28, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28758335/discordant-rapid-hiv-tests-lessons-from-a-low-resource-community
#16
A A Adetunji, M A Kuti, R A Audu, S A Muyibi, M Imhansoloeva, O A Mosuro, E A Solanke, O M Akpa, A E Irabor, Mma Ladipo, B Berzins, K Robertson, A Ogunniyi, I F Adewole, B O Taiwo
OBJECTIVES: HIV rapid antibody tests are widely used in Africa, but dual testing sometimes produces discordant results. It is not clear if discordant rapid HIV tests should always heighten suspicion by frontline health workers that early HIV infection is present. Some studies have reported that discordant rapid tests have value for identifying early HIV infection in high HIV prevalence populations. It is not known if rapid test performance influenced this conclusion, or if this observation will hold true for low HIV prevalence populations...
July 31, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28757566/health-inequities-among-lesbian-gay-and-bisexual-adults-in-north-carolina-2011-2014
#17
Melissa M Barnhill, Joseph G L Lee, Ann P Rafferty
Inequalities in health have been identified for lesbian, gay, and bisexual (LGB) populations nationally. Policies in the U.S. South offer fewer protections for LGB people than in other regions, yet, limited data exist for this region. North Carolina (NC) BRFSS data from 2011 to 2014 were combined (LGB n = 604; heterosexual n = 33,170) and analyzed using SAS survey procedures to estimate health characteristics by sexual orientation within gender. Many examined indicators were not different by sexual orientation, however, other results were significant and consistent with findings from state population surveys in other regions of the country...
July 25, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28753509/long-term-no-tillage-and-organic-input-management-enhanced-the-diversity-and-stability-of-soil-microbial-community
#18
Yi Wang, Chunyue Li, Cong Tu, Greg D Hoyt, Jared L DeForest, Shuijin Hu
Intensive tillage and high inputs of chemicals are frequently used in conventional agriculture management, which critically depresses soil properties and causes soil erosion and nonpoint source pollution. Conservation practices, such as no-tillage and organic farming, have potential to enhance soil health. However, the long-term impact of no-tillage and organic practices on soil microbial diversity and community structure has not been fully understood, particularly in humid, warm climate regions such as the southeast USA...
July 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28753279/correction-to-selenium-ecotoxicology-in-freshwater-lakes-receiving-coal-combustion-residual-effluents-a-north-carolina-example
#19
Jessica E Brandt, Emily S Bernhardt, Gary S Dwyer, Richard T Di Giulio
No abstract text is available yet for this article.
July 28, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28752540/the-effects-of-traffic-light-labelling-versus-cartoon-labelling-on-food-and-beverage-purchases-in-a-children-s-hospital-setting
#20
O R Whitt, S B Jilcott Pitts, A P Rafferty, C R Payne, S W Ng
This study's purpose was to examine changes in healthy and unhealthy items purchased following the implementation of traffic light and cartoon labelling in a small retail food venue (Café Bay) in a children's hospital in eastern North Carolina. Between October 2015 and March 2016, daily food and beverage sales from Café Bay were obtained during baseline, traffic light labelling, a washout period, cartoon labelling (on healthy foods only) and a final washout period. Pearson chi-squared tests and multiple linear regressions were used to examine effects of labelling strategies, controlling for the holidays...
July 28, 2017: Pediatric Obesity
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