Michael S McEntire, Jennifer A Landolfi, Michael J Adkesson, Mark G Papich, Samantha J Sander, Leena Roy, Alexandria Talley, Lauren Vincent, Matthew C Allender
Systemic isosporosis, previously atoxoplasmosis, is a significant cause of mortality in juvenile passerine birds. Recommended treatment regimens are empiric and vary in efficacy. The goal of this study was to determine the pharmacokinetics and pharmacodynamics of ponazuril for treatment of systemic isosporosis. Ponazuril, diluted with water to create an oral suspension (50 mg/ml), was administered (100 mg/kg) to 72 European starlings ( Sturnus vulgaris ) by a single dose via direct oral gavage (n = 24), a single dose injected into superworm larvae ( Zophobas morio ; n = 24), or a daily dose mixed with commercial dog food to top-dress feed for 5 d (n = 24)...
October 2023: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians