Yulin Duan, Zhengyi Shi, Fei Song, Zhangrong Hou, Xiaosheng Tan, Yeting Zhang, Xincai Hao, Gang Chen, Changxing Qi, Yonghui Zhang
Hyparillums A (1) and B (2), two previously unidentified polycyclic polyprenylated acylphloroglucinols (PPAPs) with intricate architectures, were isolated from Hypericum patulum Thunb. Hyparillum A was the first PPAP with eight-carbon rings based on an unprecedented 6/6/5/6/6/5/6/4 octocyclic system featuring a rare heptacyclo[10.8.1.11,10 .03,8 .08,21 .012,19 .014,17 ]docosane core. In contrast, hyparillum B featured a novel heptacyclic architecture (6/6/5/6/6/5/5) based on a hexacyclo[9.6.1.11,9 .03,7 .07,18 ...
March 2024: Chinese Journal of Natural Medicines