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https://www.readbyqxmd.com/read/29058376/prognostic-role-of-tumor-necrosis-in-patients-undergoing-curative-resection-for-gastric-gastrointestinal-stromal-tumor-a-multicenter-analysis-of-740-cases-in-china
#1
Xuechao Liu, Haibo Qiu, Peng Zhang, Xingyu Feng, Tao Chen, Yong Li, Kaixiong Tao, Guoxin Li, Xiaowei Sun, Zhiwei Zhou
Tumor necrosis is associated with poor clinical outcomes in many malignancies. We aimed to determine whether tumor necrosis was an independent predictor of outcomes in gastric gastrointestinal stromal tumors (GISTs). We retrospectively analyzed data from 740 patients undergoing curative resection for gastric GIST at four centers between 2001 and 2015. Disease-free survival (DFS) was estimated with the Kaplan-Meier method, and associations with prognosis were assessed with Cox regression models. Tumor necrosis was present in 122 cases (16...
October 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29058367/crispr-cas9-based-counterselection-boosts-recombineering-efficiency-in-pseudomonas-putida
#2
Tomás Aparicio, Víctor de Lorenzo, Esteban Martínez-García
While adoption of single-stranded (ss) DNA recombineering techniques has greatly eased genetic design of the platform strain Pseudomonas putida KT2440, available methods still produce the desired modifications/deletions at low frequencies. This makes isolation of mutants that do not display selectable or conspicuous phenotypes considerably difficult. To overcome this limitation, we have merged ssDNA recombineering with CRISPR/Cas9 technology in this bacterium for efficient killing of unmodified cells and thus non-phenotypic selection of bacteria bearing the mutations of interest...
October 23, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29058339/linking-mitochondria-and-synaptic-transmission-the-cb1-receptor
#3
REVIEW
Marie-Ange Djeungoue-Petga, Etienne Hebert-Chatelain
CB1 receptors are functionally present within brain mitochondria (mtCB1), although they are usually considered specifically targeted to plasma membrane. Acute activation of mtCB1 alters mitochondrial ATP generation, synaptic transmission, and memory performance. However, the detailed mechanism linking disrupted mitochondrial metabolism and synaptic transmission is still uncharacterized. CB1 receptors are among the most abundant G protein-coupled receptors in the brain and impact on several processes, including fear coping, anxiety, stress, learning, and memory...
October 23, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/29058311/apetala-2-domain-containing-transcription-factors-focusing-on-abscisic-acid-and-gibberellins-antagonism
#4
Kai Shu, Wenguan Zhou, Wenyu Yang
The phytohormones abscisic acid (ABA) and gibberellin (GA) antagonistically mediate diverse plant developmental processes including seed dormancy and germination, root development, and flowering time control, and thus the optimal balance between ABA and GA is essential for plant growth and development. Although more than a half and one century have passed since the initial discoveries of ABA and GA, respectively, the precise mechanisms underlying ABA-GA antagonism still need further investigation. Emerging evidence indicates that two APETALA 2 (AP2)-domain-containing transcription factors (ATFs), ABI4 in Arabidopsis and OsAP2-39 in rice, play key roles in ABA and GA antagonism...
October 23, 2017: New Phytologist
https://www.readbyqxmd.com/read/29058299/detection-of-low-abundance-point-mutations-by-competitive-strand-assisted-endonuclease-iv-signal-amplification-system
#5
Fei Xiong, Chuan-Zhen Liu, Wang-Qiang Li, Zi-Qiang Dong, Jie Zhang
Genetic mutations are important molecular biomarkers for cancer diagnosis and surveillance. Therefore, the development of methods for mutation detection characterized with straightforward, highly specific and sensitive to low-level mutations within various sequence contexts is extremely needed. Although some of the currently available methods have shown very encouraging results, their discrimination efficiency is still very low. Herein, we demonstrate a fluorescent probe coupled with blocker and property of melting temperature discrimination, which is able to identify the presence of known or unknown single-base variations at abundances down to 0...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29058285/notch4-inhibition-suppresses-invasion-and-vasculogenic-mimicry-formation-of-hepatocellular-carcinoma-cells
#6
Rui Cheng, Xin-Ran Cai, Kun Ke, Yan-Ling Chen
Vasculogenic mimicry (VM) is a process by which aggressive tumor cells generate non-endothelial cell-lined channels in malignant tumors including hepatocellular carcinoma (HCC). It has provided new insights into tumor behavior and has surfaced as a potential target for drug therapy. The molecular events underlying the process of VM formation are still poorly understood. In this study, we attempted to elucidate the relationship between Notch4 and VM formation in HCC. An effective siRNA lentiviral vector targeting Notch4 was constructed and transfected into Bel7402, a HCC cell line...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29058281/decitabine-for-relapsed-acute-lymphoblastic-leukemia-after-allogeneic-hematopoietic-stem-cell-transplantation
#7
Jie-Ke Cui, Yin Xiao, Yong You, Wei Shi, Qing Li, Yi Luo, Lin Jiang, Zhao-Dong Zhong
Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a main question on treatment failure. Current strategies for management that usually include salvage chemotherapy, donor lymphocytic infusion and second transplantation. Our study assessed the efficacy of decitabine (DAC) for treating patients with acute lymphoblastic leukemia (ALL) who relapsed after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We retrospectively analyzed the outcomes of 12 patients with relapsed ALL after allo-HSCT who received DAC therapy...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29058254/neuroprotective-effects-of-ginkgo-biloba-extract-and-ginkgolide-b-against-oxygen-glucose-deprivation-reoxygenation-and-glucose-injury-in-a-new-in-vitro-multicellular-network-model
#8
Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin
Acute ischemic stroke (AIS), as the third leading cause of death worldwide, is characterized by its high incidence, mortality rate, high incurred disability rate, and frequent reoccurrence. The neuroprotective effects of Ginkgo biloba extract (GBE) against several cerebral diseases have been reported in previous studies, but the underlying mechanisms of action are still unclear. Using a novel in vitro rat cortical capillary endothelial cellastrocyte- neuron network model, we investigated the neuroprotective effects of GBE and one of its important constituents, Ginkgolide B (GB), against oxygen-glucose deprivation/reoxygenation and glucose (OGD/R) injury...
October 2, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29058253/why-we-still-need-to-speak-about-sex-differences-and-sex-hormones-in-pain
#9
EDITORIAL
Anna Maria Aloisi
In the world of pain, we must always consider the presence of gender. In nociception, as well as in pain, women are different from men in many, if not all, aspects of the system. Nociception is the sum of several events that occur from the periphery to the CNS, and there is much evidence that female nociception differs from male nociception. Moreover, it has to be considered that pain results from a male or a female cortex. Genetic, anatomical, physiological, hormonal, psychological, and social factors have been considered to explain the differences present at both levels...
October 20, 2017: Pain and Therapy
https://www.readbyqxmd.com/read/29058246/factors-relating-caesarean-section-to-persistent-pulmonary-hypertension-of-the-newborn
#10
REVIEW
Niralee Babooa, Wen-Jing Shi, Chao Chen
BACKGROUND: Several studies have clearly demonstrated a significantly higher incidence of persistent pulmonary hypertension of the newborn (PPHN) in neonates delivered by caesarean section (CS) compared to those delivered vaginally. The pathophysiological factors underlying the link between CS and PPHN are still poorly understood. In this review, we describe the mechanisms that could explain the association between CS delivery and subsequent PPHN, as well as potential preventive measures...
December 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29058221/systems-health-a-transition-from-disease-management-toward-health-promotion
#11
Li Shen, Benchen Ye, Huimin Sun, Yuxin Lin, Herman van Wietmarschen, Bairong Shen
To date, most of the chronic diseases such as cancer, cardiovascular disease, and diabetes, are the leading cause of death. Current strategies toward disease treatment, e.g., risk prediction and target therapy, still have limitations for precision medicine due to the dynamic and complex nature of health. Interactions among genetics, lifestyle, and surrounding environments have nonnegligible effects on disease evolution. Thus a transition in health-care area is urgently needed to address the hysteresis of diagnosis and stabilize the increasing health-care costs...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29058218/ontology-based-vaccine-adverse-event-representation-and-analysis
#12
Jiangan Xie, Yongqun He
Vaccine is the one of the greatest inventions of modern medicine that has contributed most to the relief of human misery and the exciting increase in life expectancy. In 1796, an English country physician, Edward Jenner, discovered that inoculating mankind with cowpox can protect them from smallpox (Riedel S, Edward Jenner and the history of smallpox and vaccination. Proceedings (Baylor University. Medical Center) 18(1):21, 2005). Based on the vaccination worldwide, we finally succeeded in the eradication of smallpox in 1977 (Henderson, Vaccine 29:D7-D9, 2011)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29058206/role-of-cardiovascular-magnetic-resonance-in-suspected-cardiac-amyloidosis-late-gadolinium-enhancement-pattern-as-mortality-predictor
#13
M Baroni, S Nava, G Quattrocchi, A Milazzo, C Giannattasio, A Roghi, P Pedrotti
BACKGROUND: Cardiac magnetic resonance (CMR) has gained a central role in the diagnosis of cardiac amyloidosis (CA). While the diagnostic role of a typical late gadolinium enhancement (LGE) pattern (global subendocardial enhancement coupled with accelerated contrast washout) has been identified, evidence is still conflicting regarding the prognostic role of such examination. METHODS AND RESULTS: We retrospectively analysed all patients referring for CMR at Niguarda Hospital (Milan, Italy) from January 2006 to January 2015 for suspected CA...
October 20, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/29058149/picornaviridae-the-ever-growing-virus-family
#14
REVIEW
Roland Zell
Picornaviruses are small, nonenveloped, icosahedral RNA viruses with positive-strand polarity. Although the vast majority of picornavirus infections remain asymptomatic, many picornaviruses are important human and animal pathogens and cause diseases that affect the central nervous system, the respiratory and gastrointestinal tracts, heart, liver, pancreas, skin and eye. A stunning increase in the number of newly identified picornaviruses in the past decade has shown that picornaviruses are globally distributed and infect vertebrates of all classes...
October 20, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29058086/influence-of-attention-and-bolus-volume-on-brain-organization-during-swallowing
#15
Iva Jestrović, James L Coyle, Subashan Perera, Ervin Sejdić
It has been shown that swallowing involves certain attentional and cognitive resources which, when disrupted can influence swallowing function with in dysphagic patient. However, there are still open questions regarding the influence of attention and cognitive demands on brain activity during swallowing. In order to understand how brain regions responsible for attention influence brain activity during swallowing, we compared brain organization during no-distraction swallowing and swallowing with distraction...
October 20, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29058015/wnt-signaling-the-development-of-the-sympathoadrenal-paraganglionic-system-and-neuroblastoma
#16
REVIEW
Jürgen Becker, Jörg Wilting
Neuroblastoma (NB) is a tumor of the sympathoadrenal system arising in children under 15 years of age. In Germany, NB accounts for 7% of childhood cancer cases, but 11% of cancer deaths. It originates from highly migratory progenitor cells that leave the dorsal neural tube and contribute neurons and glial cells to sympathetic ganglia, and chromaffin and supportive cells to the adrenal medulla and paraganglia. Clinically, histologically and molecularly, NBs present as extremely heterogeneous, ranging from very good to very poor prognosis...
October 22, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29058010/a-ratiometric-electrochemical-strategy-for-sensitive-determination-of-furin-activity-based-on-dual-signal-amplification-and-antifouling-nanosurfaces
#17
Dazhi Yao, Wenqi Zhao, Limin Zhang, Yang Tian
Developing a sensitive and accurate method for Furin activity is still the bottleneck for understanding the role played by Furin in cell-surface systems and even in Alzheimer's disease. In this work, a ratiometric electrochemical biosensor was developed for sensitive and accurate determination of Furin activity in the cell based on dual signal amplification stemming from a peptide with multiple response sites and the antifouling gold nano-bellflowers (GBFs). A new peptide, HS-CMRVRR↓YKDFDFG (P3), was designed for the first time to be selectively cleaved by Furin at site↓...
October 23, 2017: Analyst
https://www.readbyqxmd.com/read/29057998/a-super-stretchable-and-sensitive-strain-sensor-based-on-a-carbon-nanocoil-network-fabricated-by-a-simple-peeling-off-approach
#18
Chenghao Deng, Lujun Pan, Dongmei Zhang, Chengwei Li, Habib Nasir
Despite the tremendous progress in wearable and smart strain sensors, it is still a challenge to develop a highly sensitive, stretchable, and low-cost sensor. Herein, a super stretchable and sensitive strain sensor fabricated by a simple peeling-off approach is reported. The strain sensor is prepared by peeling off a thin as-grown carbon nanocoil (CNC) film from a substrate using a stretchable polydimethylsiloxane (PDMS) film or a flexible adhesive tape. Herein, we took advantage of the spring-like morphology and the original network of the CNCs...
October 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/29057967/helicobacter-pylori-%C3%AE-glutamyl-transferase-contributes-to-colonization-and-differential-recruitment-of-t-cells-during-persistence
#19
Stefanie Wüstner, Florian Anderl, Andreas Wanisch, Corinna Sachs, Katja Steiger, Andreas Nerlich, Michael Vieth, Raquel Mejías-Luque, Markus Gerhard
Helicobacter pylori γ-glutamyl transferase (gGT) is a key bacterial virulence factor that is not only important for bacterial gastric colonization but also related to the development of gastric pathology. Despite accumulating evidence for pathogenic and immunologic functions of H. pylori gGT, it is still unclear how it supports gastric colonization and how its specific effects on the host's innate and adaptive immune responses contribute to colonization and pathology. We have compared mice showing similar bacterial load after infection with gGT-proficient or gGT-deficient H...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29057950/energetic-mitochondrial-failing-in-vitiligo-and-possible-rescue-by-cardiolipin
#20
Maria Lucia Dell'Anna, Monica Ottaviani, Daniela Kovacs, Simone Mirabilii, David A Brown, Carlo Cota, Emilia Migliano, Emanuela Bastonini, Barbara Bellei, Giorgia Cardinali, Maria Rosaria Ricciardi, Agostino Tafuri, Mauro Picardo
Vitiligo is characterized by death or functional defects of epidermal melanocytes through still controversial pathogenic process. Previously, we showed that mitochondria-driven pre-senescent phenotype diminishes the capability of vitiligo melanocytes to cope with stressful stimuli. In the current study, we investigated markers of mitochondrial energy metabolism including the PGC1a axis, and then we determined the index of mitochondrial impairment using a cytomic approach. We found in cultured epidermal vitiligo melanocytes, compared to healthy ones, low ATP, increased proton leakage, and altered expression of several glycolytic enzymes (hexokinase II, pyruvic dehydrogenase kinase 1 and pyruvic kinase M2), We suggest that the low ATP production may be sufficient in steady-state conditions but it is unable to cover further needs...
October 20, 2017: Scientific Reports
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