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https://www.readbyqxmd.com/read/28110498/neutral-losses-of-sodium-benzoate-and-benzoic-acid-in-the-fragmentation-of-the-m%C3%A2-%C3%A2-na-ions-of-methoxyfenozide-and-tebufenozide-via-intramolecular-rearrangement-in-electrospray-ionization-tandem-mass-spectrometry
#1
Yunfeng Chai, Guanwei Gao, Shanshan Shen, Xin Liu, Chengyin Lu
RATIONALE: Electrospray ionization (ESI) tandem mass spectrometry can be applied to determine structural information about organic compounds. The [M + Na](+) ion is one of the major precursor ions in ESI mass spectrometry, but its fragmentation mechanism study is still insufficient. This study reveals the interesting fragmentation reactions of the [M + Na](+) ions of methoxyfenozide and tebufenozide. METHODS: The fragmentations of the [M + Na](+) , [M + Li](+) , and [M + H](+) ions of methoxyfenozide and tebufenozide were studied using a hybrid quadrupole-orbitrap mass spectrometer and an ion trap mass spectrometer...
February 15, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28110224/emotional-intelligence-and-coping-strategies-as-determinants-of-quality-of-life-in-depressed-patient-caregiver-dyads-an-actor-partner-interdependence-analysis
#2
L Boyer, K Baumstarck, M Alessandrini, Z Hamidou, J Testart, M Serres, P Arquillière, P Auquier, T Leroy, X Zendjidjian
OBJECTIVE: Patients with major depressive disorder (MDD) and their natural caregivers experience major lifestyle difficulties. Little is known concerning dyadic (i.e., patient and natural caregiver) characteristics' impact on quality of life. In a sample of depressed patient-caregiver dyads, we examined quality of life (QoL) levels compared with the general population and whether QoL is influenced by emotional intelligence (EI) and coping strategies using the actor-partner interdependence model (APIM)...
January 8, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28110162/pregnancy-with-gestational-hypertension-or-preeclampsia-a-qualitative-exploration-of-women-s-experiences
#3
Lynne M Roberts, Gregory K Davis, Caroline S E Homer
BACKGROUND: Hypertension complicates 10% of pregnancies and involves specialised care of the woman and her baby, a longer stay in hospital, and an increased risk of physical and mental morbidity. There is limited research reporting the woman's perspective on her experience, how she coped with it psychologically, and whether the care she received influenced her experience. AIM: To gain insight into women's experience of hypertension in pregnancy and to report on what mediating factors may help improve their experience...
January 10, 2017: Midwifery
https://www.readbyqxmd.com/read/28110156/maternal-childhood-trauma-postpartum-depression-and-infant-outcomes-avoidant-affective-processing-as-a-potential-mechanism
#4
Karmel W Choi, Kathleen J Sikkema, Bavi Vythilingum, Lut Geerts, Sheila C Faure, Melissa H Watt, Annerine Roos, Dan J Stein
BACKGROUND: Women who have experienced childhood trauma may be at risk for postpartum depression, increasing the likelihood of negative outcomes among their children. Predictive pathways from maternal childhood trauma to child outcomes, as mediated by postpartum depression, require investigation. METHODS: A longitudinal sample of South African women (N=150) was followed through pregnancy and postpartum. Measures included maternal trauma history reported during pregnancy; postpartum depression through six months; and maternal-infant bonding, infant development, and infant physical growth at one year...
January 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28110071/living-nano-micro-fibrous-woven-fabric-hydrogel-composite-scaffolds-for-heart-valve-engineering
#5
Shaohua Wu, Bin Duan, Xiaohong Qin, Jonathan T Butcher
: Regeneration and repair of injured or diseased heart valves remains a clinical challenge. Tissue engineering provides a promising treatment approach to facilitate living heart valve repair and regeneration. Three-dimensional (3D) biomimetic scaffolds that possess heterogeneous and anisotropic features that approximate those of native heart valve tissue are beneficial to the successful in vitro development of tissue engineered heart valves (TEHV). Here we report the development and characterization of a novel composite scaffold consisting of nano- and micro-scale fibrous woven fabrics and 3D hydrogels by using textile techniques combined with bioactive hydrogel formation...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28110067/poly-glycerol-sebacate-elastomer-supports-bone-regeneration-by-its-mechanical-properties-being-closer-to-osteoid-tissue-rather-than-to-mature-bone
#6
S H Zaky, K W Lee, J Gao, A Jensen, K Verdelis, Y Wang, A J Almarza, C Sfeir
: Mechanical load influences bone structure and mass. Arguing the importance of load-transduction, we investigated the mechanisms inducing bone formation using an elastomeric substrate. We characterized Poly (glycerol sebacate) (PGS) in-vitro for its mechanical properties, compatibility with osteoprogenitor cells regarding adhesion, proliferation, differentiation under compression versus static cultures and in-vivo for the regeneration of a rabbit ulna critical size defect. The load-transducing properties of PGS were compared in-vitro to a stiffer poly lactic-co- glycolic-acid (PLA/PGA) scaffold of similar porosity and interconnectivity...
January 18, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28109970/migraine-headache-and-long-term-cardiovascular-outcomes-an-extended-follow-up-of-the-women-s-ischemia-syndrome-evaluation
#7
Cecil A Rambarat, Islam Y Elgendy, B Delia Johnson, Steve E Reis, Diane V Thompson, Barry L Sharaf, Vera Bittner, George Sopko, C Noel Bairey Merz, Carl J Pepine, Bina Ahmed
BACKGROUND: The association between migraine headache and cardiovascular events has been inconsistent. This study determines the long-term risk of cardiovascular events among women with and without a history of migraine headache who were under evaluation for suspected myocardial ischemia in the Women's Ischemia Syndrome Evaluation (WISE). METHODS: The WISE is a National Heart, Lung and Blood Institute sponsored prospective, multicenter study which aims to improve myocardial ischemia evaluation in women...
January 18, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28109915/ethnobotanical-survey-of-medicinal-plants-used-in-the-traditional-treatment-of-diabetes-in-chtouka-ait-baha-and-tiznit-western-anti-atlas-morocco
#8
M Barkaoui, A Katiri, H Boubaker, F Msanda
ETHNOPHARMACOLOGICAL RELEVANCE: In Morocco, diabetes mellitus is a major public health problem with more than 1.5 million cases in 2014. Medicinal plants are widely used by the Moroccan population to treat the illness. AIM OF THE STUDY: The aim of this work is to make an inventory of plant species used in folk medicine for the management of diabetes in Chtouka Ait Baha and Tiznit provinces. MATERIALS AND METHODS: The survey was carried out by means of semi-structured questionnaires...
January 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28109886/truncated-prion-protein-prp226-a-structural-view-on-its-role-in-amyloid-disease
#9
Valerija Kovač, Blaž Zupančič, Gregor Ilc, Janez Plavec, Vladka Čurin Šerbec
In the brain of patients with transmissible spongiform encephalopathies, besides PrP(Sc) aggregates, deposition of truncated PrP molecules was described. Jansen et al. reported two clinical cases with deposition of C-terminally truncated PrP, one of them ending with Tyr226. We have previously described the discovery of monoclonal antibody V5B2 that selectively recognizes this version of the prion protein, which we called PrP226*. Using monoclonal antibody V5B2 we showed that accumulation of PrP226* is characteristic for most types of human and animal TSEs...
January 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28109884/crystal-structure-and-biochemical-features-of-dye-decolorizing-peroxidase-yfex-from-escherichia-coli-o157-asp-143-and-arg-232-play-divergent-roles-toward-different-substrates
#10
Xiuhua Liu, Zenglin Yuan, Jiaxu Wang, Yaqi Cui, Shuang Liu, Yinliang Ma, Lichuan Gu, Sujuan Xu
YfeX from Escherichia coli O157 is a bacterial dye-decolorizing peroxidase that represents both dye-decoloring activity and typical peroxidase activity. We reported the crystal structure of YfeX bound to heme at 2.09 Å resolution. The YfeX monomer resembles a ferredoxin-like fold and contains two domains. The three conserved residues surrounding the heme group are His(215), Asp(143) and Arg(232). His(215) functions as the proximal axial ligand of the heme iron atom. Biochemical data show that the catalytic significance of the conserved Asp(143) and Arg(232) depends on the substrate types and that YfeX may adopt various catalytic mechanisms toward divergent substrates...
January 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28109831/common-and-specific-abnormalities-in-cortical-thickness-in-patients-with-major-depressive-and-bipolar-disorders
#11
Meiqi Niu, Ying Wang, Yanbin Jia, Junjing Wang, Shuming Zhong, Jiabao Lin, Yao Sun, Ling Zhao, Xiaojin Liu, Li Huang, Ruiwang Huang
Major depressive disorder (MDD) and bipolar disorder (BD) are severe psychiatric diseases with overlapping symptomatology. Although previous studies reported abnormal brain structures in MDD or BD patients, the disorder-specific underlying neural mechanisms remain poorly understood. The purpose of this study was to investigate the whole-brain gray matter morphological patterns in unmedicated patients with MDD or BD and to identify the shared and disease-specific brain morphological alterations in these two disorders...
January 11, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28109786/a-tetramic-acid-derivative-with-protein-tyrosine-phosphatase-1b-inhibitory-activity-and-a-new-nortriterpene-glycoside-from-the-indonesian-marine-sponge-petrosia-sp
#12
Wilmar Maarisit, Hiroyuki Yamazaki, Syu-Ichi Kanno, Ayako Tomizawa, Henki Rotinsulu, Defny S Wewengkang, Deiske A Sumilat, Kazuyo Ukai, Magie M Kapojos, Michio Namikoshi
During the search for protein tyrosine phosphatase 1B (PTP1B) inhibitors from marine organisms, the known tetramic acid derivative, melophlin C (1), was isolated as an active component together with the new nortriterpenoid saponin, sarasinoside S (2), and three homologues: sarasinosides A1 (3), I1 (4), and J (5), from the Indonesian marine sponge Petrosia sp. The structure of 2 was elucidated on the basis of its spectroscopic data. Compound 1 inhibited PTP1B activity with an IC50 value of 14.6μM, while compounds 2-5 were not active at 15...
December 31, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28109719/the-expanding-repertoire-of-g4-dna-structures
#13
Anna Varizhuk, Dmitry Ischenko, Vladimir Tsvetkov, Roman Novikov, Nikolay Kulemin, Dmitry Kaluzhny, Maria Vlasenok, Vladimir Naumov, Igor Smirnov, Galina Pozmogova
The definition of DNA and RNA G-quadruplexes (G4s) has recently been broadened to include structures with certain defects: bulges, G-vacancies or mismatches. Despite the striking progress in computational methods for assessing G4 folding propensity, predicting G4s with defects remains problematic, reflecting the enhanced sequential diversity of these motifs. "Imperfect" G4 motifs, i.e., those containing interrupted or truncated G-runs, are typically omitted from genomic analyses. We report here studies of G4s with defects and compare these structures with classical ("perfect") quadruplexes...
January 18, 2017: Biochimie
https://www.readbyqxmd.com/read/28109709/the-effect-of-gamma-irradiation-conditions-on-the-immunogenicity-of-whole-inactivated-influenza-a-virus-vaccine
#14
Shannon C David, Josyane Lau, Eve V Singleton, Rachelle Babb, Justin Davies, Timothy R Hirst, Shaun R McColl, James C Paton, Mohammed Alsharifi
Gamma-irradiation, particularly an irradiation dose of 50kGy, has been utilised widely to sterilise highly pathogenic agents such as Ebola, Marburg Virus, and Avian Influenza H5N1. We have reported previously that intranasal vaccination with a gamma-irradiated Influenza A virus vaccine (γ-Flu) results in cross-protective immunity. Considering the possible inclusion of highly pathogenic Influenza strains in future clinical development of γ-Flu, an irradiation dose of 50kGy may be used to enhance vaccine safety beyond the internationally accepted Sterility Assurance Level (SAL)...
January 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28109443/separation-of-two-distinct-o-glycoforms-of-human-iga1-by-serial-lectin-chromatography-followed-by-mass-spectrometry-o-glycan-analysis
#15
S Lehoux, T Ju
Human immunoglobulin A1 (IgA1), which carries four to six mucin-type O-glycans (O-glycans) on its hinge region (HR), is the most abundant O-glycoprotein in plasma or serum. While normal O-glycans from hematopoietic-originated cells are core 1-based complex structures, many reports showed that the IgA1 from patients with IgA nephropathy (IgAN) carries undergalactosylated or truncated O-glycans such as the Tn antigen and its sialylated version the SialylTn (STn) antigen on the HR. Yet, there is still a debate whether Tn/STn on the HR of IgA1 is specific to the IgA1 from patients with IgAN since these antigens have also been seen in serum IgA1 of healthy individuals...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28109332/structural-characteristics-of-%C3%AE-synuclein-oligomers
#16
N Cremades, S W Chen, C M Dobson
Oligomeric forms of amyloid aggregates have been detected in the brains and tissues of patients suffering from neurodegenerative disorders such as Parkinson's disease, and it is widely thought that such species are key pathogenic agents in the development and spreading of the disease; however, the study of these species has been proven to be extremely challenging, primarily as a result of their intrinsically transient nature and high levels of heterogeneity. Identifying the structural nature and the details of the mechanisms of formation and interconversion of individual oligomeric species, particularly those with high toxicity, is of fundamental importance not only for understanding the mechanisms of protein misfolding and amyloid aggregation but also for the identification of diagnostic and therapeutic targets...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28109316/adenosine-induced-ventricular-fibrillation-in-a-structurally-normal-heart-a-case-report
#17
Christopher A Rajkumar, Norman Qureshi, Fu Siong Ng, Vasileios F Panoulas, Phang Boon Lim
BACKGROUND: Adenosine is the first-line pharmacotherapy for termination of supraventricular tachycardia through its action on the atrioventricular node. However, pro-arrhythmic effects of adenosine are also recognised, most notably in the presence of pre-excited atrial fibrillation. In this case report, we describe the induction of ventricular fibrillation in a patient with no demonstrable accessory pathway, nor any other structural heart disease. This rare, idiosyncratic reaction has never previously been reported and is of relevance given the widespread and routine use of adenosine in clinical practice...
January 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28109300/knowledge-attitudes-and-practices-in-tamarind-tamarindus-indica-l-use-and-conservation-in-eastern-uganda
#18
Esther Ebifa-Othieno, Antony Mugisha, Philip Nyeko, John David Kabasa
BACKGROUND: Tamarindus indica L is one of the indigenous fruit tree species that traditionally contributes to food security and ecosystem stability in sub-Saharan Africa. We hypothesized that the indigenous people of Eastern Uganda have used T. indica for generations and developed practices that promote its conservation and therefore we expected that they possess an elaborate indigenous knowledge (IK) system and that most of them have planted the species. The aim of this study was to assess the influence of IK, attitudes and practices on the use and conservation of T...
January 21, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28109223/ab-initio-study-of-several-static-and-dynamic-properties-of-bulk-liquid-ni-near-melting
#19
B G Del Rio, L E González, D J González
Several static and dynamic properties of bulk liquid Ni at a thermodynamic state near its triple point have been evaluated by ab initio molecular dynamics simulations. The calculated static structure shows very good agreement with the available experimental data, including an asymmetric second peak in the static structure factor, which underlines a marked local icosahedral short-range order in the liquid. The dynamical structure reveals propagating density fluctuations, and the calculated dynamic structure factors, S(q,ω), show a good agreement with the inelastic x-ray scattering measurements...
January 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28109081/shope-fibroma-in-the-external-ear-canal-of-a-domestic-rabbit
#20
Shawna J
A 5-y-old, intact, 2.5-kg female domestic rabbit was presented because of blood spatter on the wall of its cage and thetoenailsof its right hind limb. Physical examination revealed a red, gelatinous mass that spanned the width of the right vertical ear canal. Radiographic images revealed a soft-tissue opacity at the base of the right ear, which was superimposed over the tympanic bulla and extended to the pinna. A CT scan revealed that the soft-tissue mass was within the vertical and horizontal portions of the right external ear canal and extended to the level of the tympanic membrane, with no bony involvement...
January 20, 2017: Comparative Medicine
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