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https://www.readbyqxmd.com/read/29229389/direct-evidence-that-klk4-is-a-hydroxyapatite-binding-protein
#1
Vidal A Perez, Jonathan E Mangum, Michael J Hubbard
The protease kallikrein 4 (KLK4) plays a pivotal role during dental enamel formation by degrading the major enamel protein, amelogenin, prior to the final steps of enamel hardening. KLK4 dysfunction is known to cause some types of developmental defect in enamel but the mechanisms responsible for transient retention of KLK4 in semi-hardened enamel matrix remain unclear. To address contradictory reports about the affinity of KLK4 for enamel hydroxyapatite-like mineral, we used pure components in quasi-physiological conditions and found that KLK4 binds hydroxyapatite directly...
December 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29220694/impulsive-responding-in-threat-and-reward-contexts-as-a-function-of-ptsd-symptoms-and-trait-disinhibition
#2
Naomi Sadeh, Jeffrey M Spielberg, Jasmeet P Hayes
We examined current posttraumatic stress disorder (PTSD) symptoms, trait disinhibition, and affective context as contributors to impulsive and self-destructive behavior in 94 trauma-exposed Veterans. Participants completed an affective Go/No-Go task (GNG) with different emotional contexts (threat, reward, and a multidimensional threat/reward condition) and current PTSD, trait disinhibition, and risky/self-destructive behavior measures. PTSD interacted with trait disinhibition to explain recent engagement in risky/self-destructive behavior, with Veterans scoring high on trait disinhibition and current PTSD symptoms reporting the highest levels of these behaviors...
November 1, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29217473/impact-of-digestion-on-the-transport-of-dextran-loaded-self-emulsified-nanoemulsion-through-mdck-epithelial-cell-monolayer-and-rat-intestines
#3
Pulkit Khatri, Jun Shao
Many of the lipids and surfactants used to prepare the self-emulsified nanoemulsion (SEN) are subjected to the gastro-intestinal enzymatic digestion, which may affect the absorption of the loaded drug. The present study was to investigate the impact of such digestion on the transport of hydrophilic macromolecules (10-kDa dextran as the model compound) loaded in SEN through the MDCK cell monolayer and ex-vivo rat intestines. FITC-labeled dextran (FD) was loaded inside the inner oil phase of SEN by the formation of FD-phospholipid solid dispersion (FDPS)...
December 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29214529/a-rapid-and-reagent-free-bioassay-for-the-detection-of-dioxin-like-compounds-and-other-aryl-hydrocarbon-receptor-ahr-agonists-using-autobioluminescent-yeast
#4
Tingting Xu, Anna Young, Enolia Marr, Gary Sayler, Steven Ripp, Dan Close
An autonomously bioluminescent Saccharomyces cerevisiae BLYAhS bioreporter was developed in this study for the simple and rapid detection of dioxin-like compounds (DLCs) and aryl hydrocarbon receptor (AhR) agonists. This recombinant yeast reporter was based on a synthetic bacterial luciferase reporter gene cassette (lux) that can produce the luciferase as well as the enzymes capable of self-synthesizing the requisite substrates for bioluminescent production from endogenous cellular metabolites. As a result, bioluminescent signal production is generated continuously and autonomously without cell lysis or exogenous reagent addition...
December 6, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29209330/the-enigma-of-heat-shock-proteins-in-immune-tolerance
#5
REVIEW
Willem van Eden, Manon A A Jansen, Irene Ludwig, Peter van Kooten, Ruurd van der Zee, Femke Broere
The fundamental problem of autoimmune diseases is the failure of the immune system to downregulate its own potentially dangerous cells, which leads to destruction of tissue expressing the relevant autoantigens. Current immunosuppressive therapies offer relief but fail to restore the basic condition of self-tolerance. They do not induce long-term physiological regulation resulting in medication-free disease remissions. Heat shock proteins (HSPs) have shown to possess the capacity of inducing lasting protective immune responses in models of experimental autoimmune diseases...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29206306/nail-extracting-behavior-as-an-unusual-manifestation-of-adjustment-disorder-confused-with-onychotillomania
#6
H Lee, W S Lee
Nails are the subject of various psychocutaneous disorders. This spectrum of disorders includes onychophagia, nail tic disorder, onychotillomania, and nail destruction associated with psychiatric disorders.[1] Although self-induced nail injuries, such as biting and rubbing, are common, there was an extraordinary case of self-inflicted, nail-extracting behaviors in an unusual presentation of adjustment disorder. This article is protected by copyright. All rights reserved.
December 5, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29206103/a-population-of-innate-myelolymphoblastoid-effector-cell-expanded-by-inactivation-of-mtor-complex-1-in-mice
#7
Fei Tang, Peng Zhang, Peiying Ye, Christopher A Lazarski, Qi Wu, Ingrid L Bergin, Timothy P Bender, Michael N Hall, Ya Cui, Liguo Zhang, Taijiao Jiang, Yang Liu, Pan Zheng
Adaptive autoimmunity is restrained by controlling population sizes and pathogenicity of harmful clones, while innate destruction is controlled at effector phase. We report here that deletion of Rptor in mouse hematopoietic stem/progenitor cells causes self-destructive innate immunity by massively increasing the population of previously uncharacterized innate myelolymphoblastoid effector cells (IMLECs). Mouse IMLECs are CD3-B220-NK1.1-Ter119- CD11clow/-CD115-F4/80low/-Gr-1- CD11b+, but surprisingly express high levels of PD-L1...
December 5, 2017: ELife
https://www.readbyqxmd.com/read/29197172/sleep-patterns-predictive-of-daytime-challenging-behavior-in-individuals-with-low-functioning-autism
#8
Simonne Cohen, Ben D Fulcher, Shantha M W Rajaratnam, Russell Conduit, Jason P Sullivan, Melissa A St Hilaire, Andrew J K Phillips, Tobias Loddenkemper, Sanjeev V Kothare, Kelly McConnell, Paula Braga-Kenyon, William Ahearn, Andrew Shlesinger, Jacqueline Potter, Frank Bird, Kim M Cornish, Steven W Lockley
Increased severity of problematic daytime behavior has been associated with poorer sleep quality in individuals with autism spectrum disorder. In this work, we investigate whether this relationship holds in a real-time setting, such that an individual's prior sleep can be used to predict their subsequent daytime behavior. We analyzed an extensive real-world dataset containing over 20,000 nightly sleep observations matched to subsequent challenging daytime behaviors (aggression, self-injury, tantrums, property destruction and a challenging behavior index) across 67 individuals with low-functioning autism living in two U...
December 1, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29191345/vasculitis-kids-are-not-just-little-people
#9
Nikita Lakdawala, Flavia Fedeles
Cutaneous vasculitis, inflammatory destruction of blood vessels, can present with a wide range of clinical and pathologic findings across a number of heterogeneous conditions. Although some vasculitides are present in both children and adults, some important differences exist in clinical presentation, etiology, management, and prognosis in childhood vasculitis versus adult vasculitis. Cutaneous vasculitis is rare in children, and most childhood vasculitides, of which Henoch-Schönlein purpura is the most common, histologically are small vessel leukocytoclastic vasculitis...
November 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/29190648/anterior-chamber-associated-immune-deviation-used-as-a-neuroprotective-strategy-in-rats-with-spinal-cord-injury
#10
Beatriz Pineda-Rodriguez, Diana Toscano-Tejeida, Elisa García-Vences, Roxana Rodriguez-Barrera, Adrian Flores-Romero, Daniela Castellanos-Canales, Gabriel Gutierrez-Ospina, Laura Castillo-Carvajal, Esperanza Meléndez-Herrera, Antonio Ibarra
The inflammatory response is probably one of the main destructive events occurring after spinal cord injury (SCI). Its progression depends mostly on the autoimmune response developed against neural constituents. Therefore, modulation or inhibition of this self-reactive reaction could help to reduce tissue destruction. Anterior chamber associated immune deviation (ACAID) is a phenomenon that induces immune-tolerance to antigens injected into the eye´s anterior chamber, provoking the reduction of such immune response...
2017: PloS One
https://www.readbyqxmd.com/read/29183347/the-effect-of-an-intensive-smoking-cessation-intervention-on-disease-activity-in-patients-with-rheumatoid-arthritis-study-protocol-for-a-randomised-controlled-trial
#11
Ida Kristiane Roelsgaard, Thordis Thomsen, Mikkel Østergaard, Robin Christensen, Merete Lund Hetland, Søren Jacobsen, Lena Andersen, Hanne Tønnesen, Silvia Rollefstad, Anne Grete Semb, Bente Appel Esbensen
BACKGROUND: Rheumatoid arthritis (RA) is a chronic, inflammatory rheumatic disease with the potential to induce significant disability. Patients with RA are at increased risk of cardiovascular diseases (CVD). Smokers with RA tend to experience more pain and fatigue, higher disease activity, more erosive joint destruction and a lower health-related quality of life (HR-QoL) than non-smokers. It remains to be determined whether these effects can be reduced by smoking cessation. This randomised controlled trial (RCT) in patients with RA aims to examine the effect of intensive smoking cessation intervention (motivational counselling combined with tailored nicotine replacement therapy) versus standard care on smoking cessation, and consequently on disease activity...
November 28, 2017: Trials
https://www.readbyqxmd.com/read/29178733/the-role-of-adhesive-materials-and-oral-biofilm-in-the-failure-of-adhesive-resin-restorations
#12
REVIEW
Roberto Pinna, Paolo Usai, Enrica Filigheddu, Franklin Garcia-Godoy, Egle Milia
PURPOSE: To critically discuss adhesive materials and oral cariogenic biofilm in terms of their potential relevance to the failures of adhesive restorations in the oral environment. METHODS: The literature regarding adhesive restoration failures was reviewed with particular emphasis on the chemistry of adhesive resins, weakness in dentin bonding, water fluids, cariogenic oral biofilm and the relations that influence failures. Particular attention was paid to evidence derived from clinical studies...
October 2017: American Journal of Dentistry
https://www.readbyqxmd.com/read/29170111/tat-modified-self-assembled-cationic-peptide-nanoparticles-as-an-efficient-antibacterial-agent
#13
Bi He, Shiyi Ma, Guifu Peng, Daohang He
The increasing emergence of drug resistant pathogenic bacteria poses a great challenge to clinical therapy and a threat to public health. Cationic peptides have received great attention for their unique antibacterial mechanism and ability to combat drug-resistant bacteria. In this study, we designed a TAT-modified cationic peptide PA-28 which self-assembled into nanoparticles of about 150nm. These nanoparticles showed strong antimicrobial activities against both gram-positive and gram-negative bacteria, including drug-resistant bacteria...
November 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29167651/nonsuicidal-self-injury-a-systematic-review
#14
Annarosa Cipriano, Stefania Cella, Paolo Cotrufo
Objective: Nonsuicidal self-injury (NSSI) refers to the intentional self-inflicted destruction of body tissue without suicidal intention and for purposes not socially sanctioned. Our paper presents an up-to-date overview on nonsuicidal, self-injurious behaviors. Method: In accordance with PRISMA guidelines, a systematic literature search was conducted across two databases, PubMed and PsycARTICLES, regarding the main features of NSSI with a focus on epidemiological and etiologic data, diagnostic criteria, and functions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29165872/manganese-dioxide-coated-ws2-fe3-o4-ssio2-nanocomposites-for-ph-responsive-mr-imaging-and-oxygen-elevated-synergetic-therapy
#15
Guangbao Yang, Rui Zhang, Chao Liang, He Zhao, Xuan Yi, Sida Shen, Kai Yang, Liang Cheng, Zhuang Liu
Recently, the development of multifunctional theranostic nanoplatforms to realize tumor-specific imaging and enhanced cancer therapy via responding or modulating the tumor microenvironment (TME) has attracted tremendous interests in the field of nanomedicine. Herein, tungsten disulfide (WS2 ) nanoflakes with their surface adsorbed with iron oxide nanoparticles (IONPs) via self-assembly are coated with silica and then subsequently with manganese dioxide (MnO2 ), on to which polyethylene glycol (PEG) is attached...
November 22, 2017: Small
https://www.readbyqxmd.com/read/29158984/virus-like-particles-as-a-platform-for-cancer-vaccine-development
#16
Hui Kian Ong, Wen Siang Tan, Kok Lian Ho
Cancers have killed millions of people in human history and are still posing a serious health problem worldwide. Therefore, there is an urgent need for developing preventive and therapeutic cancer vaccines. Among various cancer vaccine development platforms, virus-like particles (VLPs) offer several advantages. VLPs are multimeric nanostructures with morphology resembling that of native viruses and are mainly composed of surface structural proteins of viruses but are devoid of viral genetic materials rendering them neither infective nor replicative...
2017: PeerJ
https://www.readbyqxmd.com/read/29158078/self-destructive-behavior-among-full-donor-blood-and-marrow-grafts-and-the-association-with-long-term-graft-function
#17
Richard F Olsson
No abstract text is available yet for this article.
November 17, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29157207/an-ethnographic-study-of-the-effects-of-cognitive-symptoms-in-patients-with-major-depressive-disorder-the-impact-study
#18
Bjarke Ebert, Kamilla Miskowiak, Morten Kloster, Jon Johansen, Cara Eckholm, Torbjörn Wærner, Mads Holme, Louise Meldgaard Bruun
BACKGROUND: The manifestation of major depressive disorder (MDD) may include cognitive symptoms that can precede the onset of MDD and persist beyond the resolution of acute depressive episodes. However, little is known about how cognitive symptoms are experienced by MDD patients and the people around them. METHODS: In this international (Brazil, Canada, China, France, and Germany) ethnographic study, we conducted semi-structured interviews and observations of remitted as well as symptomatic MDD patients (all patients self-reported being diagnosed by an HCP and self-reported being on an antidepressant) aged 18-60 years with self-reported cognitive symptoms (N = 34)...
November 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29135442/-lottery-and-suicide-the-effect-of-number-of-lottery-tickets-on-hungarian-suicide-rates
#19
Péter Osváth, Lajos Bálint, Károly Bozsonyi
AIM: The relationship of suicide and gambling is a neglected field in the study of suicidology. In Hungary, no statistical studies have been published to date with regard to the whole of the population. Our study investigates the relationship between a very popular high prize game, lottery, and suicide rates. METHOD: The relationship between daily rates of suicide by gender and age and the number of winning tickets has been analysed over the periods between 1991 and 1997 and from 1997 to 2013...
2017: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/29131641/qcm-d-investigation-of-swelling-behavior-of-layer-by-layer-thin-films-upon-exposure-to-monovalent-ions
#20
Joshua T O'Neal, Ethan Y Dai, Yanpu Zhang, Kyle B Clark, Kathryn G Wilcox, Ian M George, Nandha E Ramasamy, Daisy Enriquez, Piotr Batys, Maria Sammalkorpi, Jodie L Lutkenhaus
Polyelectrolyte multilayers and layer-by-layer assemblies are susceptible to structural changes in response to ionic environment. By altering the salt type and ionic strength, structural changes can be induced by disruption of intrinsically bound ion pairs within the multilayer network via electrostatic screening. Notably, high salt concentrations have been used for the purposes of salt-annealing and self-healing of LbL assemblies with KBr, in particular, yielding a remarkably rapid response. However, to date, the structural and swelling effects of various monovalent ion species on the behavior of LbL assemblies remain unclear, including a quantitative view of ion content in the LbL assembly and thickness changes over a wide concentration window...
November 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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