keyword
MENU ▼
Read by QxMD icon Read
search

Self destructive

keyword
https://www.readbyqxmd.com/read/28627239/complex-multicellular-functions-at-a-unicellular-eukaryote-level-learning-memory-and-immunity
#1
György Csaba
According to experimental data, eukaryote unicellulars are able to learn, have immunity and memory. Learning is carried out in a very primitive form, and the memory is not neural but an epigenetic one. However, this epigenetic memory, which is well justified by the presence and manifestation of hormonal imprinting, is strong and permanent in the life of cell and also in its progenies. This memory is epigenetically executed by the alteration and fixation of methylation pattern of genes without changes in base sequences...
June 19, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28623084/pathogenesis-of-human-systemic-lupus-erythematosus-a-cellular-perspective
#2
REVIEW
Vaishali R Moulton, Abel Suarez-Fueyo, Esra Meidan, Hao Li, Masayuki Mizui, George C Tsokos
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs. A complex interaction of genetics, environment, and hormones leads to immune dysregulation and breakdown of tolerance to self-antigens, resulting in autoantibody production, inflammation, and destruction of end-organs. Emerging evidence on the role of these factors has increased our knowledge of this complex disease, guiding therapeutic strategies and identifying putative biomarkers. Recent findings include the characterization of genetic/epigenetic factors linked to SLE, as well as cellular effectors...
June 13, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28622540/scattering-of-airy-elastic-sheets-by-a-cylindrical-cavity-in-a-solid
#3
F G Mitri
The prediction of the elastic scattering by voids (and cracks) in materials is an important process in structural health monitoring, phononic crystals, metamaterials and non-destructive evaluation/imaging to name a few examples. Earlier analytical theories and numerical computations considered the elastic scattering by voids in plane waves of infinite extent. However, current research suggesting the use of (limited-diffracting, accelerating and self-healing) Airy acoustical-sheet beams for non-destructive evaluation or imaging applications in elastic solids requires the development of an improved analytical formalism to predict the scattering efficiency used as a priori information in quantitative material characterization...
June 8, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28622159/weeding-out-the-justification-for-marijuana-treatment-in-patients-with-developmental-and-behavioral-conditions
#4
Theodora Nelson, Yi Hui Liu, Kara S Bagot, Martin T Stein
Alex is a 13-year-old adolescent with high-functioning autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD)-combined type, anxiety, and depression. He has been resistant to engaging in therapy and treatment with various medications has been unsuccessful. Alex's parents are concerned about his anxiety, isolation, oppositional behaviors, academic underachievement, truancy, and substance use. A recent altercation with his stepfather led to a police intervention and a brief removal of Alex from the home...
June 15, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28618463/diffusion-driven-self-assembly-of-rodlike-particles-monte-carlo-simulation-on-a-square-lattice
#5
Nikolai I Lebovka, Yuri Yu Tarasevich, Volodymyr A Gigiberiya, Nikolai V Vygornitskii
The diffusion-driven self-assembly of rodlike particles was studied by means of Monte Carlo simulation. The rods were represented as linear k-mers (i.e., particles occupying k adjacent sites). In the initial state, they were deposited onto a two-dimensional square lattice of size L×L up to the jamming concentration using a random sequential adsorption algorithm. The size of the lattice, L, was varied from 128 to 2048, and periodic boundary conditions were applied along both x and y axes, while the length of the k-mers (determining the aspect ratio) was varied from 2 to 12...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28613073/dioxygen-what-makes-this-triplet-diradical-kinetically-persistent
#6
Weston Thatcher Borden, Roald Hoffmann, Thijs Stuyver, Bo Chen
Experimental heats of formation and enthalpies obtained from G4 calculations both find that the resonance stabilization of the two unpaired electrons in triplet O2, relative to the unpaired electrons in two hydroxyl radicals, amounts to 100 kcal/mol. The origin of this huge stabilization energy is described within the contexts of both molecular orbital (MO) and valence-bond (VB) theory. Although O2 is a triplet diradical, the thermodynamic unfavorability of both its hydrogen atom abstraction and oligomerization reactions can be attributed to its very large resonance stabilization energy...
June 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28607992/no-dependent-programmed-cell-death-is-involved-in-the-formation-of-zn-related-lesions-in-tobacco-leaves
#7
Aleksandra Weremczuk, Anna Ruszczyńska, Ewa Bulska, Danuta Maria Antosiewicz
A recent study indicated that the development of lesions on the leaf blades of tobacco exposed to zinc (Zn) excess can be considered a manifestation of a Zn-tolerance strategy at the organ level. Here, we investigated whether cell death leading to the formation of localized lesions is destructive in character (necrosis type) or results from programmed self-induced cell death (PCD). Selected parameters, including PCD markers, were determined in the leaves from tobacco plants grown in the presence of 200 μM Zn and compared with control conditions...
June 13, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28605317/rationalized-insights-on-causes-of-rheumatoid-arthritis-in-the-elderly-and-women-special-emphasis-on-treatment-strategies
#8
Shikha Srivastava, Satish Patel, Deependra Singh, Manju Rawat Singh
Rheumatoid arthritis (RA) is an autoimmune disorder distinguished by synovial inflammation followed by destruction of joint. The pathogenesis of arthritis involves immune imbalance of the endogenous system. Causative factors include immune imbalance, oxidative stress, genetics, and environment. Continued effort has been made to treat RA via chemical, enzymatic, genetic, and hormonal approaches. RA has been reported more in the aged and in women. Arthritis necessitates lifelong administration of drugs to maintain quality of life...
2017: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/28599652/regulatory-t-cells-in-multiple-sclerosis-and-myasthenia-gravis
#9
REVIEW
K M Danikowski, S Jayaraman, B S Prabhakar
Multiple sclerosis (MS) is a chronic debilitating disease of the central nervous system primarily mediated by T lymphocytes with specificity to neuronal antigens in genetically susceptible individuals. On the other hand, myasthenia gravis (MG) primarily involves destruction of the neuromuscular junction by antibodies specific to the acetylcholine receptor. Both autoimmune diseases are thought to result from loss of self-tolerance, which allows for the development and function of autoreactive lymphocytes. Although the mechanisms underlying compromised self-tolerance in these and other autoimmune diseases have not been fully elucidated, one possibility is numerical, functional, and/or migratory deficits in T regulatory cells (Tregs)...
June 9, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28596811/genetic-engineering-and-human-mental-ecology-interlocking-effects-and-educational-considerations
#10
Ramsey Affifi
This paper describes some likely semiotic consequences of genetic engineering on what Gregory Bateson has called "the mental ecology" (1979) of future humans, consequences that are less often raised in discussions surrounding the safety of GMOs (genetically modified organisms). The effects are as follows: an increased 1) habituation to the presence of GMOs in the environment, 2) normalization of empirically false assumptions grounding genetic reductionism, 3) acceptance that humans are capable and entitled to decide what constitutes an evolutionary improvement for a species, 4) perception that the main source of creativity and problem solving in the biosphere is anthropogenic...
2017: Biosemiotics
https://www.readbyqxmd.com/read/28581538/from-traumatic-events-and-dissociation-to-body-image-and-depression-symptoms-in-search-of-self-destruction-syndrome-in-adolescents-who-engage-in-nonsuicidal-self-injury
#11
Wioletta Radziwiłłowicz, Magdalena Lewandowska
OBJECTIVES: The aim of the study was to analyze relationships between the variables: severity of depression symptoms, feelings towards one's own body, dissociation, the number and type of traumatic life events experienced by adolescents who engage in deliberate self-injury and are psychiatrically hospitalized. METHODS: We examined 60 patients aged 13-17 (M = 15.48, SD = 1.19). More than a half (55%) were diagnosed with a mixed disturbance of emotions and conduct, 23...
April 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28573099/acellular-dermal-matrices-and-paraffinoma-a-modern-tool-for-a-nearly-obsolete-disease
#12
Luca Grassetti, Matteo Torresetti, Alessandro Scalise, Davide Lazzeri, Giovanni Di Benedetto
Paraffinoma is a destructive complication of paraffin oil injection, usually associated with massive tissue destruction, thus requiring radical surgery and subsequent complex reconstruction. Although breast and penile paraffinomas have been widely described and their management is quite standardized, paraffinomas of the knee are still rare and only few case reports or small case series are available in the current literature. We describe the case of a 77-year-old man with a large paraffinoma of the right knee that occurred after self-injection of paraffin oil, 58 years before...
May 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28565939/homicide-in-the-western-family-and-background-factors-of-a-perpetrator
#13
Anna Liisa Aho, Anni Remahl, Eija Paavilainen
AIMS: Familicide is a multiple-victim homicide incident in which the killer's spouse and one or more children are slain. A systematic review was conducted to reveal the background factors of western homicide perpetrators. METHODS: The systematic search was performed in the Arto, Medic, Cinahl, Medline, EBSCOhost Academic Search Premier and Social Services abstracts databases. The keywords were familicide, family homicide, familicide-suicide, filicide-suicide, extended suicide, child, murder, family, filicide and infanticide...
May 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28561787/production-of-recombinant-antimicrobial-polymeric-protein-beta-casein-e-50-52-and-its-antimicrobial-synergistic-effects-assessment-with-thymol
#14
Shohreh Fahimirad, Hamid Abtahi, Seyed Hadi Razavi, Houshang Alizadeh, Mansour Ghorbanpour
Accelerating emergence of antimicrobial resistance among food pathogens and consumers' increasing demands for preservative-free foods are two contemporary challenging aspects within the food industry. Antimicrobial packaging and the use of natural preservatives are promising solutions. In the present study, we used beta-casein-one of the primary self-assembly proteins in milk with a high polymeric film production capability-as a fusion partner for the recombinant expression of E 50-52 antimicrobial peptide in Escherichia coli...
May 31, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28544496/suicide-attempts-and-self-injurious-behaviours-in-adolescent-and-adult-patients-with-borderline-personality-disorder
#15
Marianne Goodman, Irene Alvarez Tomas, Christina M Temes, Garrett M Fitzmaurice, Blaise A Aguirre, Mary C Zanarini
OBJECTIVE: Prevalence data on self-mutilation and suicide attempts for adolescent borderline personality disorder (BPD) are currently not available. The purpose of this paper was to determine the frequency and methods of two forms of physically self-destructive acts (i.e. self-mutilation and suicide attempts) reported by adolescent borderline inpatients in one of the largest samples to date and to compare these results with a similarly diagnosed and assessed group of adult borderline inpatients...
May 22, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/28544231/dual-responsive-molecular-switches-based-on-dithienylethene-ru-ii-organometallics-in-self-assembled-monolayers-operating-at-low-voltage
#16
Andrea Mulas, Xiaoyan He, Yves-Marie Hervault, Lucie Norel, Stéphane Rigaut, Corinne Lagrost
Two carbon-rich ruthenium complexes bearing a dithienylethene (DTE) unit and a hexylthiol spacer were designed to be attached on gold surfaces. Both compounds display photochemically-driven switching properties, allowing reversible conversion from open to closed forms of the DTE units upon irradiation in solution. In contrast, only the bimetallic complex undergoes an efficient electrochemical ring closure at low potential, (0.5 V vs SCE), whereas the monometallic complex show a simple one electron reversible redox event...
May 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28541241/stigma-and-self-esteem-a-case-of-hiv-positive-sex-workers
#17
G Kalemi, S Gkioka, P Tsapatsari, G Tzeferakos, T Kandri, M L Psarra, F Konstantopoulou, A Douzenis
Stigma associated with sex work and HIV can be easily recognized in public reactions towards the members of discriminated groups. Nevertheless, there are only a few studies examining the impact of discrimination to the self-esteem of individuals who suffer the coexistence of multiple stigmatizing conditions. In our case, the unprecedented stigmatization of sex workers through the media as a menace of public health as well as criminals due to their seropositivity should be examined with respect and scientificity...
January 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28538163/metabolic-signatures-of-t-cells-and-macrophages-in-rheumatoid-arthritis
#18
REVIEW
Cornelia M Weyand, Markus Zeisbrich, Jörg J Goronzy
In most autoimmune diseases, a decade-long defect in self-tolerance eventually leads to clinically relevant, tissue-destructive inflammatory disease. The pathogenic potential of chronic persistent immune responses during the pre-clinical and clinical phase is ultimately linked to the bioenergetic fitness of innate and adaptive immune cells. Chronic immune cell stimulation, high cellular turn-over, structural damage to the host tissue and maladaptive wound healing, all require a reliable supply of nutrients, oxygen, and biosynthetic precursors...
May 21, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28537207/indirect-effect-of-management-support-on-users-compliance-behaviour-towards-information-security-policies
#19
Norshima Humaidi, Vimala Balakrishnan
BACKGROUND: Health information systems are innovative products designed to improve the delivery of effective healthcare, but they are also vulnerable to breaches of information security, including unauthorised access, use, disclosure, disruption, modification or destruction, and duplication of passwords. Greater openness and multi-connectedness between heterogeneous stakeholders within health networks increase the security risk. OBJECTIVE: The focus of this research was on the indirect effects of management support (MS) on user compliance behaviour (UCB) towards information security policies (ISPs) among health professionals in selected Malaysian public hospitals...
January 1, 2017: HIM Journal
https://www.readbyqxmd.com/read/28535500/transient-receptor-potential-vanilloid-5-mediates-ca2-influx-and-inhibits-chondrocyte-autophagy-in-a-rat-osteoarthritis-model
#20
Yingliang Wei, Yanfang Wang, Yutong Wang, Lunhao Bai
BACKGROUND: Autophagy, a self-protective mechanism of chondrocytes, has become a promising target to impede the progress of osteoarthritis (OA). Autophagy is regulated by cytosolic Ca2+ activity and may thus be modified by the Ca2+ permeable transient receptor potential channel vanilloid 5 (TRPV5). Therefore, we investigated the potential role of TRPV5 in mediating Ca2+ influx and in inhibiting chondrocyte autophagy in a rat OA model. METHODS: The rat OA model was assessed by macroscopic and histological analyses...
2017: Cellular Physiology and Biochemistry
keyword
keyword
4383
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"