keyword
MENU ▼
Read by QxMD icon Read
search

Self destructive

keyword
https://www.readbyqxmd.com/read/28724413/smoking-related-general-and-cause-specific-mortality-in-estonia
#1
Gea Kõks, Krista Fischer, Sulev Kõks
BACKGROUND: Tobacco smoking is known to be the single largest cause of premature death worldwide. The aim of present study was to analyse the effect of smoking on general and cause-specific mortality in the Estonian population. METHODS: The data from 51,756 adults in the Estonian Genome Center of the University of Tartu was used. Information on dates and causes of death was retrieved from the National Causes of Death Registry. Smoking status, general survival, general mortality and cause-specific mortality were analysed using Kaplan-Meier estimator and Cox proportional hazards models...
July 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28723565/the-transcription-factor-tcf1-contributes-to-normal-nk-cell-development-and-function-by-limiting-the-expression-of-granzymes
#2
Beena Jeevan-Raj, Jasmine Gehrig, Mélanie Charmoy, Vijaykumar Chennupati, Camille Grandclément, Paolo Angelino, Mauro Delorenzi, Werner Held
The transcription factor Tcf1 is essential for the development of natural killer (NK) cells. However, its precise role has not been clarified. Our combined analysis of Tcf1-deficient and transgenic mice indicated that Tcf1 guides NK cells through three stages of development. Tcf1 expression directed bone marrow progenitors toward the NK cell lineage and ensured the survival of NK-committed cells, and its downregulation was needed for terminal maturation. Impaired survival of NK-committed cells was due to excessive expression of granzyme B (GzmB) and other granzyme family members, which induced NK cell self-destruction during maturation and following activation with cytokines or target cells...
July 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28716637/update-on-the-management-of-abnormal-uterine-bleeding
#3
Yael Levy-Zauberman, Anne-Gaëlle Pourcelot, Perrine Capmas, Hervé Fernandez
Abnormal uterine bleeding (AUB) is a common complaint that affects large numbers of women from puberty to menopause. It negatively affects health by causing anemia, and impacts the quality of life of women affected. AUB also has an economic impact for both women and society. Therefore, it should not be under- or overestimate and diagnosis, investigations and treatment should be proposed, taking into account the scientific data available in the current state of medical knowledge. Using the new terminology and etiologic classification of AUB is essential to communicate properly around the subject...
July 14, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28711016/therapeutic-supermolecular-micelles-of-vitamin-e-succinate-grafted-%C3%AE%C2%B5-polylysine-as-potential-carriers-for-curcumin-enhancing-tumour-penetration-and-improving-therapeutic-effect-on-glioma
#4
He-Lin Xu, Zi-Liang Fan, De-Li ZhuGe, Bi-Xin Shen, Bing-Hui Jin, Jian Xiao, Cui-Tao Lu, Ying-Zheng Zhao
Severe toxicity and poor tumour penetration are two intrinsic limited factors to hinder the broad clinical application for most of first-line chemotherapeutics. In this study, a novel vitamin E succinate-grafted ε-polylysine (VES-g-PLL) polymer was synthesized by using ε-polylysine as backbone. By adjusting VES graft ratio, VES-g-PLL (50) with a theoretic VES graft ratio of 50% could self-assemble into a supermolecular micelle with a hydrodynamic diameter (Dh) of ca.20nm, and Zeta potential of 19.6mV. VES-g-PLL micelles themselves displayed a strong anti-tumour effect on glioma...
July 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28696135/application-of-solution-focused-brief-therapy-sfbt-in-individuals-after-stroke
#5
Hubert M Wichowicz, Lidia Puchalska, Anna M Rybak-Korneluk, Dariusz Gąsecki, Anna Wiśniewska
OBJECTIVE: To examine the effects of Solution Focused Brief Therapy (SFBT) in individuals after stroke on self-efficacy, symptoms of depression and anxiety. DESIGN: Randomized controlled trial. SETTING: Clinic of Adult Neurology of Medical University of Gdańsk and M. Copernicus Pomeranian Traumatology Centre in Gdańsk. SUBJECTS: A total of 62 patients, aged 54.0 ± 9.6 years. INTERVENTIONS: They were randomly assigned to one of the two groups: SFBT participating in 10 therapy sessions and control - not participating in any psychotherapy...
July 11, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28692883/effects-of-multi-walled-carbon-nanotubes-with-various-diameters-on-bacterial-cellular-membranes-cytotoxicity-and-adaptive-mechanisms
#6
Fan Yang, Qun Jiang, Weiling Xie, Ying Zhang
The effect of multi-walled carbon nanotubes (MWNTs) with different diameters on the destruction degree toward cellular membranes of bacterial has been explored by investigating the viability of bacteria and the change of composition and surface properties in cellular membranes with the exposure of MWNTs. The atrazine degrading bacteria Acinetobacter lwoffii DNS32 (DNS32) is chosen as the model species and Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis) are selected as the comparison specie...
July 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28691805/how-does-the-p7c3-series-of-neuroprotective-small-molecules-prevent-membrane-disruption
#7
Amin Reza Zolghadr, Maryam Heydari Dokoohaki
Molecular dynamics (MD) simulations are conducted to suggest a mechanism of action for the aminopropyl dibromocarbazole derivative (P7C3) small molecule, which protects neurons from apoptotic cell death. At first, the influence of embedded Aβ42 stacks on the structure of membrane is studied. Then, the effect of P7C3 molecules on the Aβ42 fibril enriched membrane and Aβ42 fibril depleted membrane (when Aβ42 fibrils are originally dissolved in the aqueous phase) are evaluated. Also, the formation of an amyloid ion channel in the Aβ42 enriched membrane is examined by calculating deuterium order parameter, density profile, and surface thickness...
July 20, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28686208/structural-elements-recognized-by-abacavir-induced-t-cells
#8
Daniel Yerly, Yuri Andreiw Pompeu, Ryan J Schutte, Klara K Eriksson, Anette Strhyn, Austin W Bracey, Soren Buus, David A Ostrov
Adverse drug reactions are one of the leading causes of morbidity and mortality in health care worldwide. Human leukocyte antigen (HLA) alleles have been strongly associated with drug hypersensitivities, and the causative drugs have been shown to stimulate specific T cells at the sites of autoimmune destruction. The structural elements recognized by drug-specific T cell receptors (TCRs) in vivo are poorly defined. Drug-stimulated T cells express TCRs specific for peptide/HLA complexes, but the characteristics of peptides (sequence, or endogenous or exogenous origin) presented in the context of small molecule drugs are not well studied...
July 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28673572/elimination-of-cancer-stem-cells-and-reactivation-of-latent-hiv-1-via-ampk-activation-common-mechanism-of-action-linking-inhibition-of-tumorigenesis-and-the-potential-eradication-of-hiv-1
#9
Jahahreeh Finley
Although promising treatments are currently in development to slow disease progression and increase patient survival, cancer remains the second leading cause of death in the United States. Cancer treatment modalities commonly include chemoradiation and therapies that target components of aberrantly activated signaling pathways. However, treatment resistance is a common occurrence and recent evidence indicates that the existence of cancer stem cells (CSCs) may underlie the limited efficacy and inability of current treatments to effectuate a cure...
July 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28666163/macroporous-monoliths-for-biodegradation-study-of-polymer-particles-considered-as-drug-delivery-systems
#10
M V Volokitina, V A Korzhikov-Vlakh, T B Tennikova, E G Korzhikova-Vlakh
Nanostructures based on biodegradable polymers are often considered as drug delivery systems. The properties of these nanomaterails towards in vitro biodegradation are very important and usually are studied using the model physiological conditions. In this work the novel approach based on application of monolithic immobilized enzyme reactors (IMERs) as the systems for biodegradation study of the nanoobjects of different nature and morphology was suggested. Rigid nanospheres based on poly(lactic acid) and self-assembled nanoobjects formed from block-copolymer of glutamic acid and phenylalanine were applied as model nanomaterials...
June 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28664612/autoimmune-arthritis-induces-paired-immunoglobulin-like-receptor-b-expression-on-cd4-t-cells-from-skg-mice
#11
Kathrin Rothe, Nora Raulien, Gabriele Köhler, Matthias Pierer, Dagmar Quandt, Ulf Wagner
The chronic, destructive autoimmune arthritis in SKG mice, which closely resembles human rheumatoid arthritis, is the result of self-reactive T cells escaping thymic deletion. Since the inhibitory receptor LIR-1 is up-regulated on auto-reactive T cells in human rheumatoid arthritis, the role of its murine ortholog PIR-B was investigated. Peripheral CD4(+) T cells from SKG mice were found to frequently express PIR-B, and this population produces more frequently IL-17 upon in vitro stimulation compared to PIR-B(-) cells...
June 30, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28658441/indirect-self-destructiveness-in-individuals-with-schizophrenia
#12
Konstantinos Tsirigotis
Objective: To explore the indirect self-destructiveness syndrome in patients with schizophrenia. Methods: Two hundred individuals with paranoid schizophrenia (117 men and 83 women, mean age 37.15 years), all in remission, were examined using the Polish version of the Chronic Self-Destructiveness Scale. Two hundred well-matched healthy individuals served as a control group. Results: The intensity of indirect self-destructiveness was greater in the schizophrenia group than in controls...
June 22, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28657376/glycolic-acid-peel-in-disseminated-facial-verrucae
#13
Seema Rani, Preeti Sharma
Facial warts are common cause of cosmetic concern and also affects the self-esteem of the affected patients. These are benign skin papillomas caused by human papillomavirus infections. Warts affecting the face are mainly due to HPV-3 and HPV-10. Destructive and caustic agents used for the treatment can produce scarring at these site hence should be used with care. Earlier also glycolic acid in gel based used alone as well in combination with salicylic acid with good results. We used glycolic acid peel in aqueous base with dramatic improvement...
June 28, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28654122/dissipation-of-self-assemblies-by-fusion-of-complementary-gels-an-elegant-strategy-for-programmed-enzymatic-reactions
#14
Deep Mandal, Pritam Choudhury, Deblina Sarkar, Prasanta Kumar Das
Cholesterol based phenylboronic acid and glucose tailored complementary gels were developed which underwent mutual self-destruction upon mixing due to the formation of a boronate-diol adduct. This dissipation of the complementary gels was employed in a programmed enzymatic reaction and in pro-drug activation.
July 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28647667/self-esteem-and-non-suicidal-self-injury-in-adulthood-a-systematic-review
#15
REVIEW
Rebecca L Forrester, Hayley Slater, Khowla Jomar, Susan Mitzman, Peter James Taylor
BACKGROUND: Non-suicidal self-injury (NSSI) is a self-destructive act that represents a considerable burden on the individual and society. Low self-esteem may be a psychological variable that is related to NSSI. However, little is known about the nature of this relationship in adulthood. This systematic review therefore aimed to provide a synthesis of the available literature on the relationship between self-esteem and NSSI. METHODS: Articles were independently identified and risk of bias assessed by two reviewers searching PsycINFO, CINAHL, Medline and Web of Science databases...
October 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28627239/complex-multicellular-functions-at-a-unicellular-eukaryote-level-learning-memory-and-immunity
#16
György Csaba
According to experimental data, eukaryote unicellulars are able to learn, have immunity and memory. Learning is carried out in a very primitive form, and the memory is not neural but an epigenetic one. However, this epigenetic memory, which is well justified by the presence and manifestation of hormonal imprinting, is strong and permanent in the life of cell and also in its progenies. This memory is epigenetically executed by the alteration and fixation of methylation pattern of genes without changes in base sequences...
June 19, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28623084/pathogenesis-of-human-systemic-lupus-erythematosus-a-cellular-perspective
#17
REVIEW
Vaishali R Moulton, Abel Suarez-Fueyo, Esra Meidan, Hao Li, Masayuki Mizui, George C Tsokos
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs. A complex interaction of genetics, environment, and hormones leads to immune dysregulation and breakdown of tolerance to self-antigens, resulting in autoantibody production, inflammation, and destruction of end-organs. Emerging evidence on the role of these factors has increased our knowledge of this complex disease, guiding therapeutic strategies and identifying putative biomarkers. Recent findings include the characterization of genetic/epigenetic factors linked to SLE, as well as cellular effectors...
July 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28622540/scattering-of-airy-elastic-sheets-by-a-cylindrical-cavity-in-a-solid
#18
F G Mitri
The prediction of the elastic scattering by voids (and cracks) in materials is an important process in structural health monitoring, phononic crystals, metamaterials and non-destructive evaluation/imaging to name a few examples. Earlier analytical theories and numerical computations considered the elastic scattering by voids in plane waves of infinite extent. However, current research suggesting the use of (limited-diffracting, accelerating and self-healing) Airy acoustical-sheet beams for non-destructive evaluation or imaging applications in elastic solids requires the development of an improved analytical formalism to predict the scattering efficiency used as a priori information in quantitative material characterization...
June 8, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28622159/weeding-out-the-justification-for-marijuana-treatment-in-patients-with-developmental-and-behavioral-conditions
#19
Theodora Nelson, Yi Hui Liu, Kara S Bagot, Martin T Stein
Alex is a 13-year-old adolescent with high-functioning autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD)-combined type, anxiety, and depression. He has been resistant to engaging in therapy and treatment with various medications has been unsuccessful. Alex's parents are concerned about his anxiety, isolation, oppositional behaviors, academic underachievement, truancy, and substance use. A recent altercation with his stepfather led to a police intervention and a brief removal of Alex from the home...
July 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28618463/diffusion-driven-self-assembly-of-rodlike-particles-monte-carlo-simulation-on-a-square-lattice
#20
Nikolai I Lebovka, Yuri Yu Tarasevich, Volodymyr A Gigiberiya, Nikolai V Vygornitskii
The diffusion-driven self-assembly of rodlike particles was studied by means of Monte Carlo simulation. The rods were represented as linear k-mers (i.e., particles occupying k adjacent sites). In the initial state, they were deposited onto a two-dimensional square lattice of size L×L up to the jamming concentration using a random sequential adsorption algorithm. The size of the lattice, L, was varied from 128 to 2048, and periodic boundary conditions were applied along both x and y axes, while the length of the k-mers (determining the aspect ratio) was varied from 2 to 12...
May 2017: Physical Review. E
keyword
keyword
4383
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"