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https://www.readbyqxmd.com/read/28236843/multiple-sclerosis-and-air-pollution-exposure-mechanisms-toward-brain-autoimmunity
#1
Sayed Esmaeil Mousavi, Pouria Heydarpour, Jacques Reis, Masoud Amiri, Mohammad Ali Sahraian
The association between neurodegenerative diseases and environmental exposures, in particular air pollution, has been noticed in the last two decades, but the importance of this environmental factor in multiple sclerosis (MS) pathogenesis has not been considered extensively. However, recent evidence suggests that major mechanisms involved in MS pathogenesis, such as inflammatory factors expression, free radicals overproduction, the blood brain barrier (BBB) breakdown, neuroinflammation, vitamin D deficiency and mitochondrial dysfunction could also occur due to exposure to air pollutants...
March 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28228373/statins-and-fibrates-for-diabetic-retinopathy-protocol-for-a-systematic-review
#2
Vania Mozetic, Carolina Gomes Freitas, Rachel Riera
BACKGROUND: Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus, and more than 75% of patients who have had diabetes for more than 20 years will have some degree of DR. This disease is highly destructive to self-esteem and puts a high burden on public health and pension systems due to the effects that it has on people of working age. The current mainstay of treatment is laser photocoagulation, which causes impairment of vision and discomfort to patients...
February 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28224831/fear-of-failure-can-drive-self-destructive-behaviour
#3
Michael Traynor
For many events in professional life we are given guidelines, for example how to structure your job application or how to write a report about a patient.
February 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28216695/continuous-self-sustaining-smouldering-destruction-of-simulated-faeces
#4
Ivo Fabris, Daniel Cormier, Jason I Gerhard, Tomek Bartczak, Mark Kortschot, Jose L Torero, Yu-Ling Cheng
A new approach for the rapid destruction of human waste using smouldering combustion is presented. Recently, self-sustaining smouldering combustion was shown to destroy the organic component of simulated human solid waste and dog faeces resulting in the sanitization of all pathogens using a batch process (Yermán et al., 2015). Here, a continuous smouldering process is demonstrated for the first time, allowing for a much smaller reactor size and much less energy input per mass of waste treated. The self-sustained smouldering of simulated human faeces mixed with sand is evaluated over long periods (more than 16 h) based on a single ignition...
February 15, 2017: Fuel
https://www.readbyqxmd.com/read/28212726/the-role-of-mitochondria-in-metabolism-and-cell-death
#5
REVIEW
Helin Vakifahmetoglu-Norberg, Amanda Tomie Ouchida, Erik Norberg
Mitochondria are complex organelles that play a central role in energy metabolism, control of stress responses and are a hub for biosynthetic processes. Beyond its well-established role in cellular energetics, mitochondria are critical mediators of signals to propagate various cellular outcomes. In addition mitochondria are the primary source of intracellular reactive oxygen species (ROS) generation and are involved in cellular Ca(2+) homeostasis, they contain a self-destructive arsenal of apoptogenic factors that can be unleashed to promote cell death, thus displaying a shared platform for metabolism and apoptosis...
January 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28211550/assessment-of-depressiveness-in-population-psychometric-evaluation-of-the-polish-version-of-the-cesd-r
#6
Karolina Koziara
OBJECTIVES: Psychometric evaluation of reliability and usefulness of the Polish version of the CESD-R - a revised version of the CES-D - screening test for depression. METHODS: In an online survey the CESD-R and the Beck Depression Inventory were applied to 260 participants (men and women). Reliability was assessed with Cronbach's method and split-half (odd-even) method. Same as in the original English publication, factor analysis was performed and three factors were distinguished...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28196907/acetylation-dependent-regulation-of-mdm2-e3-ligase-activity-dictates-its-oncogenic-function
#7
Naoe T Nihira, Kohei Ogura, Kouhei Shimizu, Brian J North, Jinfang Zhang, Daming Gao, Hiroyuki Inuzuka, Wenyi Wei
Abnormal activation of the oncogenic E3 ubiquitin ligase murine double minute 2 (MDM2) is frequently observed in human cancers. By ubiquitinating the tumor suppressor p53 protein, which leads to its proteasome-mediated destruction, MDM2 limits the tumor-suppressing activity of p53. On the other hand, by ubiquitinating itself, MDM2 targets itself for destruction and promotes the p53 tumor suppressor pathway, a process that can be antagonized by the deubiquitinase herpesvirus-associated ubiquitin-specific protease (HAUSP)...
February 14, 2017: Science Signaling
https://www.readbyqxmd.com/read/28166684/pathogenic-mechanisms-of-ige-mediated-inflammation-in-self-destructive-autoimmune-responses
#8
Rachel Ettinger, Jodi L Karnell, Jill Henault, Santosh K Panda, Jeffrey M Riggs, Roland Kolbeck, Miguel A Sanjuan
Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their role in allergies, IgE autoantibodies are not associated with a higher rate of atopy in these patients. However, recently they have been recognized as active drivers of autoimmunity through mechanisms involving the secretion of Type I interferons by plasmacytoid dendritic cells (pDC), the recruitment of basophils to lymph nodes, and the activation of adaptive immune responses through B and T cells...
February 2017: Autoimmunity
https://www.readbyqxmd.com/read/28165498/two-dimensional-talbot-self-imaging-via-electromagnetically-induced-lattice
#9
Feng Wen, Wei Wang, Irfan Ahmed, Hongxing Wang, Yiqi Zhang, Yanpeng Zhang, Abdul Rasheed Mahesar, Min Xiao
We propose a lensless optical method for imaging two-dimensional ultra-cold atoms (or molecules) in which the image can be non-locally observed by coincidence recording of entangled photon pairs. In particular, we focus on the transverse and longitudinal resolutions of images under various scanning methods. In addition, the role of the induced nonmaterial lattice on the image contrast is investigated. Our work shows a non-destructive and lensless way to image ultra-cold atoms or molecules that can be further used for two-dimensional atomic super-resolution optical testing and sub-wavelength lithography...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28157168/regulation-of-t-cell-activation-and-differentiation-by-extracellular-vesicles-and-their-pathogenic-role-in-systemic-lupus-erythematosus-and-multiple-sclerosis
#10
REVIEW
Cristina Ulivieri, Cosima T Baldari
How autoreactive tissue-infiltrated effector T cells are induced and sustained in autoimmune disease, usually dominated by the Th1 and Th17 subsets, is still largely unknown. In organ-specific autoimmunity, self-reactive T cells initially activated by dendritic cells (DCs) in the lymph nodes migrate and infiltrate into the target tissues where their reactivation by peripheral tissue antigen is a prerequisite for effector cytokine production and tissue destruction. The target tissue microenvironment, as well as the local microenvironment at the immune synapse formed by T cells that encounter cognate antigen presenting cells (APCs) shave recently emerged as critical factors in shaping the differentiation and function of self-reactive effector T cells, providing the signals required for their activation in the form of the self-antigen and cytokine milieu...
February 2, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28137882/e3-ubiquitin-ligase-mule-targets-%C3%AE-catenin-under-conditions-of-hyperactive-wnt-signaling
#11
Carmen Dominguez-Brauer, Rahima Khatun, Andrew J Elia, Kelsie L Thu, Parameswaran Ramachandran, Shakiba P Baniasadi, Zhenyue Hao, Lisa D Jones, Jillian Haight, Yi Sheng, Tak W Mak
Wnt signaling, named after the secreted proteins that bind to cell surface receptors to activate the pathway, plays critical roles both in embryonic development and the maintenance of homeostasis in many adult tissues. Two particularly important cellular programs orchestrated by Wnt signaling are proliferation and stem cell self-renewal. Constitutive activation of the Wnt pathway resulting from mutation or improper modulation of pathway components contributes to cancer development in various tissues. Colon cancers frequently bear inactivating mutations of the adenomatous polyposis coli (APC) gene, whose product is an important component of the destruction complex that regulates β-catenin levels...
January 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28133644/aggressive-periodontitis-the-unsolved-mystery
#12
Danielle Clark, Maria Febbraio, Liran Levin
Aggressive periodontal disease is an oral health mystery. Our current understanding of this disease is that specific bacteria invade the oral cavity and the host reacts with an inflammatory response leading to mass destruction of the alveolar bone. Aggressive periodontal disease is typically observed in a population under the age of 30 and occurs so rapidly that it is difficult to treat. Unfortunately, the consequence of this disease frequently involves tooth extractions. As a result, the aftermath is chewing disability and damage to self-esteem due to an altered self-image...
2017: Quintessence International
https://www.readbyqxmd.com/read/28108850/baicalein-promotes-neuronal-and-behavioral-recovery-after-intracerebral-hemorrhage-via-suppressing-apoptosis-oxidative-stress-and-neuroinflammation
#13
Ning Wei, Yinghai Wei, Binru Li, Linlin Pang
Intracerebral hemorrhage (ICH) is an important public health problem in neurology, which is not only associated with high mortality but also leading to disability. Yet no satisfactory treatment has been developed. The secondary injury that resulted from a number of self-destructive processes such as neuroinflammation, apoptosis and oxidative stress, is the key factor contributing to ICH-induced brain damage. Baicalein has been proved to improve neuronal functional recovery in rat model of subarachnoid hemorrhage and ischemic brain damage...
January 21, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28101748/romantic-attachment-conflict-resolution-styles-and-teen-dating-violence-victimization
#14
Helena Bonache, Rosaura Gonzalez-Mendez, Barbara Krahé
Although research on dating violence has increased in the last decades, little is known about the role of romantic attachment and conflict resolution in understanding victimization by an intimate partner among adolescents. This study examined the relationships between insecure attachment styles, destructive conflict resolution strategies, self-reported and perceived in the partner, and psychological and physical victimization by a dating partner in 1298 adolescents (49% girls). Anxious attachment was related to both forms of victimization via self-reported conflict engagement and conflict engagement attributed to the partner among boys and girls...
January 18, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28077966/marital-relationship-parenting-practices-and-social-skills-development-in-preschool-children
#15
Rikuya Hosokawa, Toshiki Katsura
BACKGROUND: This study examined the pathways by which destructive and constructive marital conflict leading to social skills development in preschool children, are mediated through negative and positive parenting practices. METHODS: Mothers of 2931 Japanese children, aged 5-6 years, completed self-report questionnaires regarding their marital relationship (the Quality of co-parental communication scale) and parental practices (the Alabama parenting questionnaire)...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28073373/t-cell-exhaustion-from-pathophysiological-basics-to-tumor-immunotherapy
#16
REVIEW
Kemal Catakovic, Eckhard Klieser, Daniel Neureiter, Roland Geisberger
The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoimmunity and immunopathology. One of the mechanisms that have evolved to prevent destruction by the immune system, is to functionally silence effector T cells, termed T cell exhaustion, which is also exploited by viruses and cancers for immune escape In this review, we discuss some of the phenotypic markers associated with T cell exhaustion and we summarize current strategies to reinvigorate exhausted T cells by blocking these surface marker using monoclonal antibodies...
January 5, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28068114/he-never-willed-to-have-the-will-he-has-historicist-narratives-civilized-blame-and-the-need-to-distinguish-two-notions-of-free-will
#17
Michael J Gill, Stephanie C Cerce
Harsh blame can be socially destructive. This article examines how harsh blame can be "civilized." A core construct here is the historicist narrative, which is a story-like account of how a person came to be the sort of person she is. We argue that historicist narratives regarding immoral actors can temper blame and that this happens via a novel mechanism. To illuminate that mechanism, we offer a novel theoretical perspective on lay beliefs about free will. We distinguish 2 senses of free will: (a) Freedom of action, which portrays the will as a dynamic choice-making mechanism and concerns whether the actor can exert volitional control via that mechanism at the time of action, and (b) Control of self-formation, which portrays the will as an enduring disposition (e...
January 9, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28062285/a-review-on-strategies-for-decreasing-e-%C3%A2-coli-o157-h7-risk-in-animals
#18
REVIEW
Pardis Saeedi, Maryam Yazdanparast, Elham Behzadi, Ali Hatef Salmanian, Seyed Latif Mousavi, Shahram Nazarian, Jafar Amani
Enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 is a food-borne pathogen that younger children are most prone to this microorganism. Hemolytic Uremic Syndrome (HUS) caused by EHEC, leads to the destruction of red blood cells and kidney failure. The virulence of E.coli O157:H7 is attributed to fimbriae, that facilitate colonization of bacteria within the colon and verotoxins (VT) or Shiga toxins (Stx) that are released into the blood. Although, in most cases, the infection is self-limitedin young children and aged population, it may cause HUS...
January 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28059290/self-calibration-single-lens-3d-video-extensometer-for-high-accuracy-and-real-time-strain-measurement
#19
Xinxing Shao, Mohammed Mokhtar Eisa, Zhenning Chen, Shuai Dong, Xiaoyuan He
The accuracy of strain measurement using a common optical extensometer with two-dimensional (2D) digital image correlation (DIC) is not sufficient for experimental applications due to the effect of out-of-plane motion. Although three-dimensional (3D) DIC can measure all three components of displacement without introducing in-plane displacement errors, 3D-DIC requires the stringent synchronization between two digital cameras and requires complicated system calibration of binocular stereovision, which makes the measurement rather inconvenient...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28050982/effect-of-tannic-acid-on-bond-strength-of-etch-and-rinse-and-self-etch-adhesive-systems-in-dentin-of-primary-teeth
#20
Masoumeh Ebrahimi, Alireza Sarraf Shirazi, Faraneh Abdolhoseinpour, Mojtaba Abdollahi
INTRODUCTION: One of the possible mechanisms for the gradual destruction of bond strength in dentin-resin interface, could be due to the demineralized unstable collagen matrix. Use of protease inhibitors, such as tannic acid (TA) could prevent destruction of collagen fibers. The aim of this study was to compare the TA effect on bond strength of etch and rinse and self-etch adhesive systems in the dentin of primary teeth. MATERIALS AND METHODS: This in vitro study was done on 40 extracted primary molar teeth...
January 1, 2017: Journal of Contemporary Dental Practice
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