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https://www.readbyqxmd.com/read/29649364/unambiguous-signature-of-the-berry-phase-in-intense-laser-dissociation-of-diatomic-molecules
#1
Foudhil Bouakline
We report strong evidence of Berry phase effects in intense laser dissociation of D2 + molecules, manifested as Aharonov-Bohm-like oscillations in the photofragments angular distribution (PAD). Our calculations show that this interference pattern strongly depends on the parity of the diatom initial rotational state, (-1)j . Indeed, the PAD local maxima (minima) observed in one case (j odd) correspond to local minima (maxima) in the other case (j even). Using simple topological arguments, we clearly show that such interference conversion is a direct signature of the Berry phase...
April 12, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29644213/immunotherapy-plus-cryotherapy-potential-augmented-abscopal-effect-for-advanced-cancers
#2
REVIEW
Joe Abdo, David L Cornell, Sumeet K Mittal, Devendra K Agrawal
Since the 1920s the gold standard for treating cancer has been surgery, which is typically preceded or followed with chemotherapy and/or radiation, a process that perhaps contributes to the destruction of a patient's immune defense system. Cryosurgery ablation of a solid tumor is mechanistically similar to a vaccination where hundreds of unique antigens from a heterogeneous population of tumor cells derived from the invading cancer are released. However, releasing tumor-derived self-antigens into circulation may not be sufficient enough to overcome the checkpoint escape mechanisms some cancers have evolved to avoid immune responses...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29628906/positive-and-negative-affect-schedule-short-form-factorial-invariance-and-optimistic-and-pessimistic-affective-profiles-in-spanish-children
#3
Ricardo Sanmartín, María Vicent, Carolina Gonzálvez, Cándido J Inglés, Ángela Díaz-Herrero, Lucía Granados, José M García-Fernández
The distinction in recent years between positive affect (PA) and negative affect (NA) is becoming increasingly important due to their relationship with depression and anxiety. This work is composed of two studies. The first study aimed to validate the brief version of the Positive and Negative Affect Schedule for Children-Short Form (PANAS-C-SF) in a Spanish child sample. The second study sought to check the existence of four affective profiles: self-fulfilling (high PA and low NA), low affective (low PA and NA), high affective (high PA and NA), and self-destructive (low PA and high NA) and to relate them to optimism and pessimism...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29625181/hyaluronan-in-immune-dysregulation-and-autoimmune-diseases
#4
REVIEW
Nadine Nagy, Hedwich F Kuipers, Payton L Marshall, Esther Wang, Gernot Kaber, Paul L Bollyky
The tissue microenvironment contributes to local immunity and to the pathogenesis of autoimmune diseases - a diverse set of conditions characterized by sterile inflammation, immunity against self-antigens, and destruction of tissues. However, the specific factors within the tissue microenvironment that contribute to local immune dysregulation in autoimmunity are poorly understood. One particular tissue component implicated in multiple autoimmune diseases is hyaluronan (HA), an extracellular matrix (ECM) polymer...
April 3, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29608215/prospective-study-of-removing-solar-lentigines-in-asians-using-a-novel-dual-wavelength-and-dual-pulse-width-picosecond-laser
#5
Kei Negishi, Hirotaka Akita, Yukiko Matsunaga
OBJECTIVES: Quality-switched (QS) lasers are known to be an effective treatment for removing solar lentigines, however, high incidence of post-inflammatory hyperpigmentation (PIH) is a concern in darker skin types. The objective of this study was to evaluate the efficacy and safety of a dual-wavelength and dual-pulse width picosecond Nd:YAG laser for removing solar lentigines in Asians. METHODS: This was a prospective, IRB-approved study. Twenty cases with solar lentigines on the face were enrolled for treatment and evaluated at 1- and 3-month after the final treatment...
April 2, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29599783/metabolic-adaptations-of-cd4-t-cells-in-inflammatory-disease
#6
REVIEW
Cristina Dumitru, Agnieszka M Kabat, Kevin J Maloy
A controlled and self-limiting inflammatory reaction generally results in removal of the injurious agent and repair of the damaged tissue. However, in chronic inflammation, immune responses become dysregulated and prolonged, leading to tissue destruction. The role of metabolic reprogramming in orchestrating appropriate immune responses has gained increasing attention in recent years. Proliferation and differentiation of the T cell subsets that are needed to address homeostatic imbalance is accompanied by a series of metabolic adaptations, as T cells traveling from nutrient-rich secondary lymphoid tissues to sites of inflammation experience a dramatic shift in microenvironment conditions...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29596402/prevalence-of-diagnosed-diabetes-in-adults-by-diabetes-type-united-states-2016
#7
Kai McKeever Bullard, Catherine C Cowie, Sarah E Lessem, Sharon H Saydah, Andy Menke, Linda S Geiss, Trevor J Orchard, Deborah B Rolka, Giuseppina Imperatore
Currently 23 million U.S. adults have been diagnosed with diabetes (1). The two most common forms of diabetes are type 1 and type 2. Type 1 diabetes results from the autoimmune destruction of the pancreas's beta cells, which produce insulin. Persons with type 1 diabetes require insulin for survival; insulin may be given as a daily shot or continuously with an insulin pump (2). Type 2 diabetes is mainly caused by a combination of insulin resistance and relative insulin deficiency (3). A small proportion of diabetes cases might be types other than type 1 or type 2, such as maturity-onset diabetes of the young or latent autoimmune diabetes in adults (3)...
March 30, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29594116/prevalence-of-igg-autoantibodies-against-gd3-ganglioside-in-acute-zika-virus-infection
#8
Dirlei Nico, Luciana Conde, Juan L Rivera-Correa, Andréia Vasconcelos-Dos-Santos, Louise Mesentier-Louro, Leonardo Freire-de-Lima, Mônica Barcellos Arruda, Celio Geraldo Freire-de-Lima, Orlando da Costa Ferreira, Maria Elisabeth Lopes Moreira, Andrea Araújo Zin, Zilton Farias Meira Vasconcelos, Rosalia Mendez Otero, Clarisa Beatriz Palatnik-de-Sousa, Amilcar Tanuri, Adriane Regina Todeschini, Wilson Savino, Ana Rodriguez, Alexandre Morrot
Zika virus (ZIKV) disease has become a global health emergency with devastating effects on public health. Recent evidences implicate the virus as an emergent neuropathological agent promoting serious pathologies of the human nervous system, that include destructive and malformation consequences such as development of ocular and fetal brain lesions, microcephaly in neonates, and Guillain-Barré syndrome (GBS) in adults. These neurological disorders of both central and peripheral nervous systems are thought to be associated to the neurotropic properties of the virus that has ability to infect neural stem cells as well as peripheral neurons, a hallmark of its pathogenicity...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29588576/a-4-year-non-randomized-comparative-phase-iv-study-of-early-rheumatoid-arthritis-integrative-anthroposophic-medicine-for-patients-with-preference-against-dmards-versus-conventional-therapy-including-dmards-for-patients-without-preference
#9
Harald J Hamre, Van N Pham, Christian Kern, Rolf Rau, Jörn Klasen, Ute Schendel, Lars Gerlach, Attyla Drabik, Ludger Simon
Background: While disease-modifying antirheumatic drugs (DMARDs) are a mainstay of therapy for rheumatoid arthritis (RA), some patients with early RA refuse DMARDs. In anthroposophic medicine (AM), a treatment strategy for early RA without DMARDs has been developed. Preliminary data suggest that RA symptoms and inflammatory markers can be reduced under AM, without DMARDs. Patients and methods: Two hundred and fifty-one self-selected patients aged 16-70 years, starting treatment for RA of <3 years duration, without prior DMARD therapy, participated in a prospective, non-randomized, comparative Phase IV study...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29584689/extracellular-matrix-as-a-regulator-of-epidermal-stem-cell-fate
#10
REVIEW
Elina Chermnykh, Ekaterina Kalabusheva, Ekaterina Vorotelyak
Epidermal stem cells reside within the specific anatomic location, called niche, which is a microenvironment that interacts with stem cells to regulate their fate. Regulation of many important processes, including maintenance of stem cell quiescence, self-renewal, and homeostasis, as well as the regulation of division and differentiation, are common functions of the stem cell niche. As it was shown in multiple studies, extracellular matrix (ECM) contributes a lot to stem cell niches in various tissues, including that of skin...
March 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29577450/posttraumatic-stress-disorder-and-complex-posttraumatic-stress-disorder-in-dsm-5-and-icd-11-clinical-and-behavioral-correlates
#11
Philip Hyland, Mark Shevlin, Claire Fyvie, Thanos Karatzias
The American Psychiatric Association and the World Health Organization provide distinct trauma-based diagnoses in the fifth edition of the Diagnostic and Statistical Manual (DSM-5), and the forthcoming 11th version of the International Classification of Diseases (ICD-11), respectively. The DSM-5 conceptualizes posttraumatic stress disorder (PTSD) as a single, broad diagnosis, whereas the ICD-11 proposes two "sibling" disorders: PTSD and complex PTSD (CPTSD). The objectives of the current study were to: (a) compare prevalence rates of PTSD/CPTSD based on each diagnostic system; (b) identify clinical and behavioral variables that distinguish ICD-11 CPTSD and PTSD diagnoses; and (c) examine the diagnostic associations for ICD-11 CPTSD and DSM-5 PTSD...
March 25, 2018: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29575897/directional-transport-of-a-liquid-drop-between-parallel-nonparallel-combinative-plates
#12
Yao Huang, Liang Hu, Wenyu Chen, Xin Fu, Xiaodong Ruan, Haibo Xie
Liquids confined between two parallel plates can perform the function of transmission, support or lubrication in many practical applications, due to which to maintain liquids stable within their working area is very important. However, instabilities may lead to the formation of leaking drops outside the bulk liquid, thus it is necessary to transport the detached drops back without overstepping the working area and causing destructive leakage to the system. In this study, we report a novel and facile method to solve this problem by introducing the wedgelike geometry into the parallel gap to form a parallel-nonparallel combinative construction...
March 25, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29567804/primary-traumatic-axonopathy-in-mice-subjected-to-impact-acceleration-a-reappraisal-of-pathology-and-mechanisms-with-high-resolution-anatomical-methods
#13
Nikolaos K Ziogas, Vassilis E Koliatsos
Traumatic axonal injury (TAI) is a common neuropathology in traumatic brain injury (TBI) and is featured by primary injury to axons. Here, we generated TAI with impact acceleration of the head (IA) in male Thy1-eYFP-H transgenic mice in which specific populations of neurons and their axons are labeled with yellow fluorescent protein (YFP). This model results in axonal lesions in multiple axonal tracts along with blood brain barrier (BBB) disruption and neuroinflammation. The corticospinal tract (CST), a prototypical long tract, is severely affected and is the focus of this study...
March 22, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29553939/gabriela-mistral-who-she-was-and-what-she-did-for-education-retrospectroscope
#14
Max E Valentinuzzi
Education is no doubt the foundation of any healthy society. When it is lacking or substandard in quality, all sorts of misery may arise, from poverty and disease to outright delinquency and destructive (or even self-destructive) behavior. The daily news from all around this troubled world often appalls and frightens us: such atrocious and disgraceful behavior generates a vicious cycle that serves to stir up even greater depravity. It is my contention that most, if not all, of these barbarities could be prevented if more people were provided the opportunity for a well-rounded, thoughtfully conceived education [1]...
March 2018: IEEE Pulse
https://www.readbyqxmd.com/read/29541210/primary-non-hodgkin-lymphoma-of-the-right-femur-and-subsequent-metastasis-to-the-left-femur-a-case-report-and-literature-review
#15
Jing-Yu Hu, Dan Yu, Yao-Hui Wu
Non-Hodgkin lymphoma of the bone is rare and typically causes an extensive bone lesion. The present study describes a case of diffuse large B-cell primary non-Hodgkin lymphoma of the bone, which occurred in the right femur, and was initially treated with surgery and chemotherapy. Following a 7-year period of complete remission, a new, similar lesion was identified in the left femur. With both lesions, there was no accompanying destruction of any other bones or organ involvement. Metastasis of PLB to the contralateral side is extremely rare and, to the best of our knowledge, this is the first report of this particular presentation in China or worldwide...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29541078/peptide-immunotherapy-for-type-1-diabetes-clinical-advances
#16
REVIEW
Emma L Smith, Mark Peakman
Autoimmune and allergic diseases occur when an individual mounts an inappropriate immune response to a self-antigen or an innocuous environmental antigen. This triggers a pathogenic T-cell response resulting in damage to specific tissues and organs. In type 1 diabetes (T1D), this manifests as destruction of the insulin-secreting β cells, resulting in a life-long dependency on recombinant insulin. Modulation of the pathogenic T-cell response with antigen-specific peptide immunotherapy offers the potential to restore the immune homeostasis and prevent further tissue destruction...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29538697/risk-stratification-for-melanoma-models-derived-and-validated-in-a-purpose-designed-prospective-cohort
#17
Catherine M Olsen, Nirmala Pandeya, Bridie S Thompson, Jean Claude Dusingize, Penelope M Webb, Adele C Green, Rachel E Neale, David C Whiteman
Background: Risk stratification can improve the efficacy and cost-efficiency of screening programs for early detection of cancer. We sought to derive a risk stratification tool for melanoma that was suitable for the general population using only self-reported information. Methods: We used melanoma risk factor information collected at baseline from QSKIN, a prospective cohort study of Queensland adults age 40 to 69 years at recruitment (n = 41 954). We examined two separate outcomes: 1) invasive melanomas and 2) all melanomas (invasive + in situ) obtained through data linkage to the cancer registry...
March 11, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29525058/how-common-are-challenging-behaviours-amongst-individuals-with-fragile-x-syndrome-a-systematic-review
#18
REVIEW
Rebecca Lyndsey Hardiman, Peter McGill
Fragile X Syndrome (FXS) appears to be associated with an increased risk for engaging in challenging behaviour, particularly self-injury, relative to those with mixed aetiology learning disabilities. Such behavioural issues are reported to be of high concern for those providing support. As such, this systematic review aimed to gain further epidemiological data regarding challenging behaviours in individuals with FXS, including: self-injurious behaviour (SIB), hand-biting as a specific topography of SIB, aggression and property destruction...
March 7, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29522498/an-experimental-study-on-static-and-dynamic-strain-sensitivity-of-embeddable-smart-concrete-sensors-doped-with-carbon-nanotubes-for-shm-of-large-structures
#19
Andrea Meoni, Antonella D'Alessandro, Austin Downey, Enrique García-Macías, Marco Rallini, A Luigi Materazzi, Luigi Torre, Simon Laflamme, Rafael Castro-Triguero, Filippo Ubertini
The availability of new self-sensing cement-based strain sensors allows the development of dense sensor networks for Structural Health Monitoring (SHM) of reinforced concrete structures. These sensors are fabricated by doping cement-matrix mterials with conductive fillers, such as Multi Walled Carbon Nanotubes (MWCNTs), and can be embedded into structural elements made of reinforced concrete prior to casting. The strain sensing principle is based on the multifunctional composites outputting a measurable change in their electrical properties when subjected to a deformation...
March 9, 2018: Sensors
https://www.readbyqxmd.com/read/29521070/non-suicidal-self-injury-nssi-and-suicidal-criteria-differentiation
#20
REVIEW
Joanna Halicka, Andrzej Kiejna
There are 2 types of basic self-destructive behavior: suicide and non-suicidal self-injury (NSSI). Currently, more and more researchers point out significant disorders which are NSSI behavior. This phenomenon is not new; NSSI seemingly has always been present in society, and certainly in approx. 10% of the population worldwide in recent times. Despite the enormous scale of the phenomenon, so far it has been overlooked and marginalized. They were considered transient behavior, typical of adolescence, a part of youthful rebellion...
February 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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