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https://www.readbyqxmd.com/read/28108850/baicalein-promotes-neuronal-and-behavioral-recovery-after-intracerebral-hemorrhage-via-suppressing-apoptosis-oxidative-stress-and-neuroinflammation
#1
Ning Wei, Yinghai Wei, Binru Li, Linlin Pang
Intracerebral hemorrhage (ICH) is an important public health problem in neurology, which is not only associated with high mortality but also leading to disability. Yet no satisfactory treatment has been developed. The secondary injury that resulted from a number of self-destructive processes such as neuroinflammation, apoptosis and oxidative stress, is the key factor contributing to ICH-induced brain damage. Baicalein has been proved to improve neuronal functional recovery in rat model of subarachnoid hemorrhage and ischemic brain damage...
January 21, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28101748/romantic-attachment-conflict-resolution-styles-and-teen-dating-violence-victimization
#2
Helena Bonache, Rosaura Gonzalez-Mendez, Barbara Krahé
Although research on dating violence has increased in the last decades, little is known about the role of romantic attachment and conflict resolution in understanding victimization by an intimate partner among adolescents. This study examined the relationships between insecure attachment styles, destructive conflict resolution strategies, self-reported and perceived in the partner, and psychological and physical victimization by a dating partner in 1298 adolescents (49% girls). Anxious attachment was related to both forms of victimization via self-reported conflict engagement and conflict engagement attributed to the partner among boys and girls...
January 18, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28077966/marital-relationship-parenting-practices-and-social-skills-development-in-preschool-children
#3
Rikuya Hosokawa, Toshiki Katsura
BACKGROUND: This study examined the pathways by which destructive and constructive marital conflict leading to social skills development in preschool children, are mediated through negative and positive parenting practices. METHODS: Mothers of 2931 Japanese children, aged 5-6 years, completed self-report questionnaires regarding their marital relationship (the Quality of co-parental communication scale) and parental practices (the Alabama parenting questionnaire)...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28073373/t-cell-exhaustion-from-pathophysiological-basics-to-tumor-immunotherapy
#4
REVIEW
Kemal Catakovic, Eckhard Klieser, Daniel Neureiter, Roland Geisberger
The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoimmunity and immunopathology. One of the mechanisms that have evolved to prevent destruction by the immune system, is to functionally silence effector T cells, termed T cell exhaustion, which is also exploited by viruses and cancers for immune escape In this review, we discuss some of the phenotypic markers associated with T cell exhaustion and we summarize current strategies to reinvigorate exhausted T cells by blocking these surface marker using monoclonal antibodies...
January 5, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28068114/he-never-willed-to-have-the-will-he-has-historicist-narratives-civilized-blame-and-the-need-to-distinguish-two-notions-of-free-will
#5
Michael J Gill, Stephanie C Cerce
Harsh blame can be socially destructive. This article examines how harsh blame can be "civilized." A core construct here is the historicist narrative, which is a story-like account of how a person came to be the sort of person she is. We argue that historicist narratives regarding immoral actors can temper blame and that this happens via a novel mechanism. To illuminate that mechanism, we offer a novel theoretical perspective on lay beliefs about free will. We distinguish 2 senses of free will: (a) Freedom of action, which portrays the will as a dynamic choice-making mechanism and concerns whether the actor can exert volitional control via that mechanism at the time of action, and (b) Control of self-formation, which portrays the will as an enduring disposition (e...
January 9, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28062285/a-review-on-strategies-for-decreasing-e-%C3%A2-coli-o157-h7-risk-in-animals
#6
REVIEW
Pardis Saeedi, Maryam Yazdanparast, Elham Behzadi, Ali Hatef Salmanian, Seyed Latif Mousavi, Shahram Nazarian, Jafar Amani
Enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 is a food-borne pathogen that younger children are most prone to this microorganism. Hemolytic Uremic Syndrome (HUS) caused by EHEC, leads to the destruction of red blood cells and kidney failure. The virulence of E.coli O157:H7 is attributed to fimbriae, that facilitate colonization of bacteria within the colon and verotoxins (VT) or Shiga toxins (Stx) that are released into the blood. Although, in most cases, the infection is self-limitedin young children and aged population, it may cause HUS...
January 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28059290/self-calibration-single-lens-3d-video-extensometer-for-high-accuracy-and-real-time-strain-measurement
#7
Xinxing Shao, Mohammed Mokhtar Eisa, Zhenning Chen, Shuai Dong, Xiaoyuan He
The accuracy of strain measurement using a common optical extensometer with two-dimensional (2D) digital image correlation (DIC) is not sufficient for experimental applications due to the effect of out-of-plane motion. Although three-dimensional (3D) DIC can measure all three components of displacement without introducing in-plane displacement errors, 3D-DIC requires the stringent synchronization between two digital cameras and requires complicated system calibration of binocular stereovision, which makes the measurement rather inconvenient...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28050982/effect-of-tannic-acid-on-bond-strength-of-etch-and-rinse-and-self-etch-adhesive-systems-in-dentin-of-primary-teeth
#8
Masoumeh Ebrahimi, Alireza Sarraf Shirazi, Faraneh Abdolhoseinpour, Mojtaba Abdollahi
INTRODUCTION: One of the possible mechanisms for the gradual destruction of bond strength in dentin-resin interface, could be due to the demineralized unstable collagen matrix. Use of protease inhibitors, such as tannic acid (TA) could prevent destruction of collagen fibers. The aim of this study was to compare the TA effect on bond strength of etch and rinse and self-etch adhesive systems in the dentin of primary teeth. MATERIALS AND METHODS: This in vitro study was done on 40 extracted primary molar teeth...
January 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28042514/quality-of-life-of-persons-injured-on-9-11-qualitative-analysis-from-the-world-trade-center-health-registry
#9
Lisa M Gargano, Robyn R Gershon, Robert M Brackbill
INTRODUCTION: A number of studies published by the World Trade Center Health Registry (Registry) document the prevalence of injuries sustained by victims of the World Trade Center Disaster (WTCD) on 9/11. Injury occurrence during or in the immediate aftermath of this event has been shown to be a risk factor for long-term adverse physical and mental health status. More recent reports of ongoing physical health and mental health problems and overall poor quality of life among survivors led us to undertake this qualitative study to explore the long-term impact of having both disaster-related injuries and peri-event traumatic exposure on quality of life in disaster survivors...
October 27, 2016: PLoS Currents
https://www.readbyqxmd.com/read/28039390/lysosomal-degradation-of-intracellular-nucleic-acids-multiple-autophagic-pathways
#10
Yuuki Fujiwara, Keiji Wada, Tomohiro Kabuta
Cell metabolism can be considered as a process of serial construction and destruction of cellular components, both of which must be regulated accurately. In eukaryotic cells, a variety of cellular components are actively delivered into lysosomes/vacuoles, specialized compartments for hydrolysis of macromolecules. Such processes of 'self-eating' are called autophagy. Despite a wide variety of lysosomal/vacuolar hydrolases, much of the interest has been focused on the proteolytic functions of autophagy and less attention has been devoted to the degradation of other macromolecules such as nucleic acids...
December 30, 2016: Journal of Biochemistry
https://www.readbyqxmd.com/read/28025941/bone-a-fertile-soil-for-cancer-metastasis
#11
Thomas Coughlin, Ricardo Romero Moreno, Devon Mason, Lukas Nystrom, Joel Boerckel, Glen Niebur, Laurie E Littlepage
Bone is one of the most common and most dangerous sites for metastatic growth across cancer types, and bone metastasis remains incurable. However, the processes by which cancers preferentially metastasize to bone are not well understood. In this review we summarize the morphological features, physical properties, and cell signaling events that make bone a unique site for metastasis and bone remodeling. The signaling crosstalk between the tumor cells and bone cells begins a vicious cycle, which describes the self-sustaining feedback loop between the tumor cells and the bone microenvironment composed of osteoclasts, osteoblasts, other bone marrow cells, bone matrix, and vasculature to support both tumor growth and bone destruction...
December 26, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/28013554/the-emerging-roles-of-b-cells-as-partners-and-targets-in-periodontitis
#12
Moncef Zouali
Initial studies of periodontal disease suggested that T cell-mediated immunity against oral Gram-negative microorganisms is a key player in the pathogenesis of this inflammatory disease. Recent investigations, however, revealed that B cells are also engaged. Given their chief role in innate-like and adaptive immune responses, B cells could exert protective functions in periodontitis. However, the periodontal bacteria-specific antibody response is generally unable to halt disease progression in affected subjects, suggesting that the antibodies produced could exhibit low anti-bacterial blocking functions or opsonophagocytic potential, and/or unfavorable effects...
December 26, 2016: Autoimmunity
https://www.readbyqxmd.com/read/28013328/network-approach-to-the-symptom-level-association-between-alcohol-use-disorder-and-posttraumatic-stress-disorder
#13
Mohammad H Afzali, Matthew Sunderland, Philip J Batterham, Natacha Carragher, Alison Calear, Tim Slade
PURPOSE: The high prevalence of alcohol use disorder among individuals with a history of trauma and posttraumatic stress disorder is well documented. The current study applied network analysis to map the structure of symptom associations between these disorders. METHODS: Data come from a community sample of 449 Australian adults with a history of trauma and alcohol consumption during the last 12 months. Data analysis consisted of the construction of the comorbidity network of PTSD/AUD symptoms, identification of the bridging symptoms, computation of the centrality measures, and evaluation of the robustness of the results...
December 24, 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27998140/highly-flexible-superhydrophobic-and-fire-resistant-layered-inorganic-paper
#14
Fei-Fei Chen, Ying-Jie Zhu, Zhi-Chao Xiong, Tuan-Wei Sun, Yue-Qin Shen
Traditional paper made from plant cellulose fibers is easily destroyed by either liquid or fire. In addition, the paper making industry consumes a large amount of natural trees and thus causes serious environmental problems including excessive deforestation and pollution. In consideration of the intrinsic flammability of organics and minimizing the effects on the environment and creatures, biocompatible ultralong hydroxyapatite nanowires are an ideal building material for inorganic fire-resistant paper. Herein, a new kind of free-standing, highly flexible, superhydrophobic, and fire-resistant layered inorganic paper has been successfully prepared using ultralong hydroxyapatite nanowires as building blocks after the surface modification with sodium oleate...
December 21, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27996036/conformation-driven-quantum-interference-effects-mediated-by-through-space-conjugation-in-self-assembled-monolayers
#15
Marco Carlotti, Andrii Kovalchuk, Tobias Wächter, Xinkai Qiu, Michael Zharnikov, Ryan C Chiechi
Tunnelling currents through tunnelling junctions comprising molecules with cross-conjugation are markedly lower than for their linearly conjugated analogues. This effect has been shown experimentally and theoretically to arise from destructive quantum interference, which is understood to be an intrinsic, electronic property of molecules. Here we show experimental evidence of conformation-driven interference effects by examining through-space conjugation in which π-conjugated fragments are arranged face-on or edge-on in sufficiently close proximity to interact through space...
December 20, 2016: Nature Communications
https://www.readbyqxmd.com/read/27995002/reproductive-biology-and-breeding-system-of-saraca-asoca-roxb-de-wilde-a-vulnerable-medicinal-plant
#16
G R Smitha, V Thondaiman
Ashoka (Saraca asoca) is a perennial, evergreen tree valued for its ornamental flowers and medicinal values. This species is classified as 'vulnerable' under IUCN list due to its dwindling population because of destructive harvesting from natural habitats. Therefore, conservation and multiplication of this species is need of the hour to utilize its astonishing medicinal uses eternally. Conservation approaches of any plant species require in-depth study of its reproductive biology, which is lacking in this species...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27994511/autophagy-activation-protects-shock-wave-induced-renal-tubular-epithelial-cell-apoptosis-may-through-modulation-of-akt-gsk-3%C3%AE-pathway
#17
Qingzhi Long, Xiang Li, Hui He, Dalin He
PURPOSE: Extracorporeal shock wave lithotripsy (ESWL) is well documented to exert destructive effect to renal cells and its mechanism is not clear. Autophagy is one of cell basic response for stressful conditions and it is important to determine cell's fate. The aim of this study is to elucidate the role of autophagy in the process of shock wave-induced renal cells injury. METHODS: NRK-52E cell, a rat renal tubular epithelial cell, was exposed to shock wave at the voltage of 14KV...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27990282/the-complement-system-an-evolution-in-progress
#18
REVIEW
Berhane Ghebrehiwet
The complement system, which consists of three independent but interacting pathways, constitutes a powerful arm of innate immunity. Its major function is to recognize and destroy pathogenic microorganisms as well as eliminate modified self-antigens. Although it is a fine-tuned system with innate capacity to discriminate self from non-self as well as danger from non-danger signals, an unwarranted activation can nonetheless occur and cause tissue destruction. To prevent such activation, specific regulators present both in plasma and on the cell surface tightly control it...
2016: F1000Research
https://www.readbyqxmd.com/read/27980987/engineering-intrinsically-zirconium-89-radiolabeled-self-destructing-mesoporous-silica-nanostructures-for-in-vivo-biodistribution-and-tumor-targeting-studies
#19
Shreya Goel, Feng Chen, Shijie Luan, Hector F Valdovinos, Sixiang Shi, Stephen A Graves, Fanrong Ai, Todd E Barnhart, Charles P Theuer, Weibo Cai
A systematic study of in vitro and in vivo behavior of biodegradable mesoporous silica nanoparticles (bMSNs), designed to carry multiple cargos (both small and macromolecular drugs) and subsequently self-destruct following release of their payloads, is presented. Complete degradation of bMSNs is seen within 21 d of incubation in simulated body fluid. The as-synthesized bMSNs are intrinsically radiolabeled with oxophilic zirconium-89 ((89)Zr, t1/2 = 78.4 h) radionuclide to track their in vivo pharmacokinetics via positron emission tomography imaging...
November 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27969068/psychological-characteristics-of-self-harming-behavior-in-korean-adolescents
#20
Woo Kyeong Lee
Recently, self-injury is drawing the attention of researchers and clinicians. The purpose of this study was to investigate the prevalence and psychological characteristics of adolescents who engage in self-harm and to examine the risk factors for engaging in this harmful behavior among Korean mid-adolescents. Participants were 784 adolescents aged 13-15 years. They completed self-report questionnaires that assessed (1) Non-Suicidal Self-Injury: the Self-Harm Questionnaire, Toronto Alexithymia Scale; (2) depression: Children's Depression Inventory; (3) adolescent-parent relationship: Parental Bonding Instrument; (4) peer attachment: Inventory of Parent and Peer Attachment; and (5) academic stress...
October 2016: Asian Journal of Psychiatry
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