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https://www.readbyqxmd.com/read/29236984/longitudinal-association-between-brain-amyloid-beta-and-gait-in-the-mayo-clinic-study-of-aging
#1
Alexandra M V Wennberg, Timothy G Lesnick, Christopher G Schwarz, Rodolfo Savica, Clinton E Hagen, Rosebud O Roberts, David S Knopman, John H Hollman, Prashanthi Vemuri, Clifford R Jack, Ronald C Petersen, Michelle M Mielke
Background: The longitudinal association between cerebral amyloid-beta (Aβ) and change in gait, and whether this association is mediated by cortical thickness, has yet to be determined. Methods: We included 439 clinically normal (CN) participants, aged 50-69 years and enrolled in the Mayo Clinic Study of Aging with cerebral Aβ, cortical thickness, and gait measurements. Cerebral Aβ deposition was assessed by Pittsburgh Compound B (PiB)-PET in multiple regions of interest (ROIs) (i...
December 9, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29201996/a-randomized-exploratory-molecular-imaging-study-targeting-amyloid-%C3%AE-with-a-novel-8-oh-quinoline-in-alzheimer-s-disease-the-pbt2-204-imagine-study
#2
Victor L Villemagne, Christopher C Rowe, Kevin J Barnham, Robert Cherny, Michael Woodward, Svetlana Bozinosvski, Olivier Salvado, Pierrick Bourgeat, Keyla Perez, Christopher Fowler, Alan Rembach, Paul Maruff, Craig Ritchie, Rudy Tanzi, Colin L Masters
Introduction: We are developing a second generation 8-OH quinoline (2-(dimethylamino) methyl-5, 7-dichloro-8-hydroxyquinoline [PBT2, Prana Biotechnology]) for targeting amyloid β (Aβ) in Alzheimer's disease (AD). In an earlier phase IIa, 3 month trial, PBT2 lowered cerebrospinal fluid Aβ by 13% and improved cognition (executive function) in a dose-related fashion in early AD. We, therefore, sought to learn whether PBT2 could alter the Aβ-PET signal in subjects with prodromal or mild AD, in an exploratory randomized study over a 12-month phase in a double-blind and a 12-month open label extension phase trial design...
November 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29198244/depressive-and-anxiety-symptoms-and-cortical-amyloid-deposition-among-cognitively-normal-elderly-persons-the-mayo-clinic-study-of-aging
#3
Janina Krell-Roesch, Val J Lowe, Jennifer Neureiter, Anna Pink, Rosebud O Roberts, Michelle M Mielke, Prashanthi Vemuri, Gorazd B Stokin, Teresa J Christianson, Clifford R Jack, David S Knopman, Bradley F Boeve, Walter K Kremers, Ronald C Petersen, Yonas E Geda
BACKGROUND: Little is known about the association of cortical Aβ with depression and anxiety among cognitively normal (CN) elderly persons. METHODS: We conducted a cross-sectional study derived from the population-based Mayo Clinic Study of Aging in Olmsted County, Minnesota; involving CN persons aged ≥ 60 years that underwent PiB-PET scans and completed Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Cognitive diagnosis was made by an expert consensus panel...
December 4, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29192126/entorhinal-tau-pathology-episodic-memory-decline-and-neurodegeneration-in-aging
#4
Anne Maass, Samuel N Lockhart, Theresa M Harrison, Rachel K Bell, Taylor Mellinger, Kaitlin Swinnerton, Suzanne L Baker, Gil D Rabinovici, William J Jagust
The medial temporal lobe (MTL) is an early site of tau accumulation and MTL dysfunction may underlie episodic memory decline in aging and dementia. Postmortem data indicate that tau pathology in the transentorhinal cortex is common by age 60, whereas spread to neocortical regions and worsening of cognition is associated with beta-amyloid (Aβ). We used [18F]AV-1451 and [11C]PiB PET, structural MRI, and neuropsychological assessment to investigate how in vivo tau accumulation in temporal lobe regions, Aβ, and MTL atrophy contribute to episodic memory in cognitively normal older adults (n=83; age=77±6yrs, 58% female)...
November 30, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29176753/centiloid-method-evaluation-for-amyloid-pet-of-subcortical-vascular-dementia
#5
Hyuk Jin Yun, Seung Hwan Moon, Hee Jin Kim, Samuel N Lockhart, Yearn Seong Choe, Kyung Han Lee, Duk L Na, Jong-Min Lee, Sang Won Seo
Reference region selection is important for proper amyloid PET analysis, especially in subcortical vascular dementia (SVaD) patients. We investigated reference region differences between SVaD and Alzheimer's disease (AD) using Centiloid scores. In 57 [C-11] Pittsburgh compound B (PiB) positive (+) AD and 23 PiB (+) SVaD patients, we assessed standardized PiB uptake and Centiloid scores in disease-specific cortical regions, with several reference regions: cerebellar gray (CG), whole cerebellum (WC), WC with brainstem (WC + B), pons, and white matter (WM)...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29163142/low-serum-phosphorus-correlates-with-cerebral-a%C3%AE-deposition-in-cognitively-impaired-subjects-results-from-the-kbase-study
#6
Jong-Chan Park, Sun-Ho Han, Min S Byun, Dahyun Yi, Jun Ho Lee, Kyua Park, Dong Young Lee, Inhee Mook-Jung
Alzheimer's disease (AD), characterized by progressive cognitive decline, is the most prevalent neurodegenerative disease in the elderly. Cerebral β-amyloid (Aβ) deposition is the major pathological hallmark of AD. Recent studies also have shown that the serum level of phosphorus correlates to the risk of incident dementia. To date, the linkage between cerebral Aβ deposition and the serum phosphorus level remains unknown. In this study, we analyzed the levels of serum phosphorus in 109 mild cognitive impairment (MCI) and 73 AD dementia (ADD) subjects...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29159058/local-and-distant-relationships-between-amyloid-tau-and-neurodegeneration-in-alzheimer-s-disease
#7
Leonardo Iaccarino, Gautam Tammewar, Nagehan Ayakta, Suzanne L Baker, Alexandre Bejanin, Adam L Boxer, Maria Luisa Gorno-Tempini, Mustafa Janabi, Joel H Kramer, Andreas Lazaris, Samuel N Lockhart, Bruce L Miller, Zachary A Miller, James P O'Neil, Rik Ossenkoppele, Howard J Rosen, Daniel R Schonhaut, William J Jagust, Gil D Rabinovici
The relationships between β-amyloid (Aβ), tau and neurodegeneration within Alzheimer's Disease pathogenesis are not fully understood. To explore these associations in vivo, we evaluated 30 Aβ PET-positive patients (mean ± sd age 62.4 ± 8.3) with mild probable AD and 12 Aβ PET-negative healthy controls (HC) (mean ± sd age 77.3 ± 6.9) as comparison. All participants underwent 3 T MRI, 11C-PiB (Aβ) PET and 18F-AV1451 (tau) PET. Multimodal correlation analyses were run at both voxel- and region-of-interest levels...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29141366/-in-vitro-early-detection-of-amyloid-plaques-in-alzheimer-s-disease-by-pittsburgh-compound-b-modified-magnetic-nanoparticles
#8
J Q Zeng, J Q Wu, M H Li, P J Wang
Objective: To construct magnetic nanoparticles targeting β-amyloid (Aβ) plaques, the pathological biomarker of Alzheimer's disease (AD) and to study their binding capability in vitro. Methods: Superparamagnetic nanoparticles Mn(0.6)Zn(0.4)Fe(2)O(4) (MZF) were coated with amphiphilic star-block copolymeric micelles and modified with Aβ-specific probe Pittsburgh compound B (PiB) to construct a novel magnetic nanoparticle MZF-PiB, which specifically targeted amyloid plaques. Transmission electron microscope was used to study the morphological features of MZF-PiB...
November 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29135331/imaging-microglial-activation-and-amyloid-burden-in-amnestic-mild-cognitive-impairment
#9
Dunja Knezevic, Nicolaas Paul Lg Verhoeff, Sina Hafizi, Antonio P Strafella, Ariel Graff-Guerrero, Tarek Rajji, Bruce G Pollock, Sylvain Houle, Pablo M Rusjan, Romina Mizrahi
Amnestic mild cognitive impairment (aMCI) is defined as a transitional state between normal aging and Alzheimer's disease (AD). Given the replicated finding of increased microglial activation in AD, we sought to investigate whether microglial activation is also elevated in aMCI and whether it is related to amyloid beta (Aβ) burden in-vivo . Eleven aMCI participants and 14 healthy volunteers completed positron emission tomography (PET) scans with [(18)F]-FEPPA and [(11)C]-PIB. Given the known sensitivity in affinity of second-generation TSPO radioligands, participants were genotyped for the TSPO polymorphism and only high-affinity binders were included...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29116483/pittsburgh-compound-b-pib-pet-imaging-of-meningioma-and-other-intracranial-tumors
#10
Derek R Johnson, Christopher H Hunt, Mark A Nathan, Joseph E Parisi, Bradley F Boeve, Melissa E Murray, David S Knopman, Clifford R Jack, Ronald C Petersen, Val J Lowe, Geoffrey B Johnson
Meningiomas are the most common intracranial tumors. Diagnosis by MRI is generally straightforward, but lack of imaging specificity can present a diagnostic dilemma, particularly in patients with cancer. We report our experience with meningioma identification on Pittsburgh compound B (PiB) PET/CT. Patients who underwent PiB PET/CT from 2006 to 2015 were reviewed to identify those with intracranial tumors. Tumor types were classified by MR appearance, or by pathology when available. Maximum standardized uptake value (SUVmax) measurements of tumor PiB activity were compared across tumor types...
November 8, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29111487/cortical-%C3%AE-amyloid-burden-gray-matter-and-memory-in-adults-at-varying-apoe-%C3%AE%C2%B54-risk-for-alzheimer-s-disease
#11
Adam P Mecca, Nicole M Barcelos, Shuo Wang, Anna Brück, Nabeel Nabulsi, Beata Planeta-Wilson, Jennifer Nadelmann, Amanda L Benincasa, Jim Ropchan, Yiyun Huang, Joel Gelernter, Peter H Van Ness, Richard E Carson, Christopher H van Dyck
Models of preclinical Alzheimer's disease (AD) propose that cerebral amyloidosis leads to neurodegeneration and subsequent cognitive decline. This study investigated whether APOE genotype is related to β-amyloid (Aβ) burden in brain regions preferentially affected by AD and whether Aβ burden is associated with gray-matter (GM) fraction (as a marker of neurodegeneration) and episodic memory performance in cognitively normal middle-aged individuals at varying genetic risk for AD. Three groups of cognitively normal participants aged 50-65 years with a first-degree family history of AD (APOE genotype ε4ε4 [n = 15], ε3ε4 [n = 15], and ε3ε3 [n = 15]) underwent [11C]PiB positron emission tomography scans to quantify cortical Aβ, brain magnetic resonance imaging, and neuropsychological testing...
January 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29082576/longitudinal-cortical-thinning-and-cognitive-decline-in-patients-with-early-versus-late-stage-subcortical-vascular-mci
#12
Juyoun Lee, Sang Won Seo, Jin-Ju Yang, Young Kyoung Jang, Jin San Lee, Yeo Jin Kim, Juhee Chin, Jong Min Lee, Sung Tae Kim, Kyung-Han Lee, Jae Hong Lee, Jae Seung Kim, Seonwoo Kim, Heejin Yoo, Ae Young Lee, Duk L Na, Hee Jin Kim
BACKGROUND AND PURPOSE: Biomarker changes in cognitively impaired patients with small vessel disease is largely unknown. We evaluated the rate of amyloid/lacune progression, cortical thinning, and cognitive decline in subcortical vascular mild cognitive impairment (svMCI) patients. METHODS: Seventy two svMCI patients were divided into early stage (ES-svMCI, n=39) and late stage (LS-svMCI, n=33) according to their clinical dementia rating sum of box score. Patients were annually followed-up with neuropsychological tests and brain MRI for three years, and underwent a second [(11) C] Pittsburgh compound B (PiB)-PET within a mean interval of 32...
October 30, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29081745/changes-of-functional-and-directed-resting-state-connectivity-are-associated-with-neuronal-oscillations-apoe-genotype-and-amyloid-deposition-in-mild-cognitive-impairment
#13
Lars Michels, Muthuraman Muthuraman, Abdul R Anwar, Spyros Kollias, Sandra E Leh, Florian Riese, Paul G Unschuld, Michael Siniatchkin, Anton F Gietl, Christoph Hock
The assessment of effects associated with cognitive impairment using electroencephalography (EEG) power mapping allows the visualization of frequency-band specific local changes in oscillatory activity. In contrast, measures of coherence and dynamic source synchronization allow for the study of functional and effective connectivity, respectively. Yet, these measures have rarely been assessed in parallel in the context of mild cognitive impairment (MCI) and furthermore it has not been examined if they are related to risk factors of Alzheimer's disease (AD) such as amyloid deposition and apolipoprotein ε4 (ApoE) allele occurrence...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29067345/ponezumab-in-mild-to-moderate-alzheimer-s-disease-randomized-phase-ii-pet-pib-study
#14
Jaren W Landen, Niels Andreasen, Carol L Cronenberger, Pamela F Schwartz, Anne Börjesson-Hanson, Henrik Östlund, Catherine A Sattler, Brendon Binneman, Martin M Bednar
INTRODUCTION: The safety, pharmacokinetics, and effect on peripheral and central amyloid β (Aβ) of multiple doses of ponezumab, an anti-Aβ monoclonal antibody, were characterized in subjects with mild-to-moderate Alzheimer's disease treated for 1 year. METHODS: Subjects were aged ≥50 years with Mini-Mental State Examination scores 16 to 26. Cohort Q was randomized to ponezumab 10 mg/kg (n = 12) or placebo (n = 6) quarterly. Cohort M was randomized to a loading dose of ponezumab 10 mg/kg or placebo, followed by monthly ponezumab 7...
September 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29060753/11c-pib-pet-image-analysis-for-alzheimer-s-diagnosis-using-weighted-voting-ensembles
#15
Wenjun Wu, Janani Venugopalan, May D Wang
Alzheimer's Disease (AD) is one of the leading causes of death and dementia worldwide. Early diagnosis confers many benefits, including improved care and access to effective treatment. However, it is still a medical challenge due to the lack of an efficient and inexpensive way to assess cognitive function [1]. Although research on data from Neuroimaging and Brain Initiative and the advancement in data analytics has greatly enhanced our understanding of the underlying disease process, there is still a lack of complete knowledge regarding the indicative biomarkers of Alzheimer's Disease...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054046/surface-modification-of-polyisobutylene-via-grafting-amino-acid-based-poly-acryloyl-6-aminocaproic-acid-as-multifunctional-material
#16
Yanqiu Du, Chunming Li, Jing Jin, Chao Li, Wei Jiang
Amino acid-based P(acryloyl-6-aminocaproic acid) (PAACA) brushes were fabricated on polyisobutylene (PIB) surface combined with plasma pre-treatment and UV-induced grafting polymerization to construct an antifouling and functional material. The hydrophilicity and hemocompatibility of PIB were largely improved by surface modification of AACA, which were confirmed by water contact angle and platelet adhesion, respectively. PAACA brushes were precisely located onto the surface of PIB to create a patterned PIB-g-PAACA structure, and then the carboxyl groups on PAACA was activated to immobilize functional protein-Concanavalin A (Con A)...
October 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29053874/tau-pathology-and-neurodegeneration-contribute-to-cognitive-impairment-in-alzheimer-s-disease
#17
Alexandre Bejanin, Daniel R Schonhaut, Renaud La Joie, Joel H Kramer, Suzanne L Baker, Natasha Sosa, Nagehan Ayakta, Averill Cantwell, Mustafa Janabi, Mariella Lauriola, James P O'Neil, Maria L Gorno-Tempini, Zachary A Miller, Howard J Rosen, Bruce L Miller, William J Jagust, Gil D Rabinovici
Neuropathological and in vivo studies have revealed a tight relationship between tau pathology and cognitive impairment across the Alzheimer's disease spectrum. However, tau pathology is also intimately associated with neurodegeneration and amyloid pathology. The aim of the present study was therefore to assess whether grey matter atrophy and amyloid pathology contribute to the relationship between tau pathology, as measured with 18F-AV-1451-PET imaging, and cognitive deficits in Alzheimer's disease. We included 40 amyloid-positive patients meeting criteria for mild cognitive impairment due to Alzheimer's disease (n = 5) or probable Alzheimer's disease dementia (n = 35)...
October 7, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29051953/effects-of-multifunctional-cross-linkers-on-rheology-and-adhesion-of-soft-nanostructured-materials
#18
X Callies, C Véchambre, C Fonteneau, F Herbst, J-M Chenal, S Pensec, L Chazeau, W H Binder, L Bouteiller, C Creton
We investigate the nanostructure, the rheology and the adhesion of soft supramolecular materials elaborated by blending monofunctional and multifunctional poly(isobutene) (PIB) chains. Monofunctional PIB chains (PIBUT) are linear and unentangled polymer chains (Mn ≈ 3 kg mol(-1)) functionalized in the middle by a bis-urea interacting moiety, able to self-associate by four hydrogen bonds. Covalent coupling of monofunctional PIB allows us to synthesize longer chains bearing two or three interacting moieties...
November 8, 2017: Soft Matter
https://www.readbyqxmd.com/read/29036824/alzheimer-s-disease-biomarkers-and-future-decline-in-cognitive-normal-older-adults
#19
Julien Dumurgier, Bernard J Hanseeuw, Frances B Hatling, Kelly A Judge, Aaron P Schultz, Jasmeer P Chhatwal, Deborah Blacker, Reisa A Sperling, Keith A Johnson, Bradley T Hyman, Teresa Gómez-Isla
BACKGROUND: Identifying older adults at risk of cognitive decline represents a challenge as Alzheimer's disease (AD) modifying therapies move toward preclinical stages. OBJECTIVE: To investigate the relationship between AD biomarkers and subsequent change in cognition in a cohort of cognitively intact older adults. METHODS: 84 cognitively normal subjects (mean age 72.0 years, 59% women) were recruited through the Massachusetts Alzheimer's Disease Research Center and the Harvard Aging Brain Study and followed over 3 years...
October 12, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29029888/reirradiation-using-permanent-interstitial-brachytherapy-a-potentially-durable-technique-for-salvaging-recurrent-pelvic-malignancies
#20
Jonathan Feddock, Dennis Cheek, Cole Steber, Jason Edwards, Stacey Slone, Wei Luo, Marcus Randall
PURPOSE: To present a time-to-failure (TTF) analysis for all patients treated with permanent interstitial brachytherapy (PIB) at our institution, with additional analyses to correlate successful reirradiation and to identify the frequency of severe grade 3 to 4 toxicity. METHODS AND MATERIALS: Forty-two previously irradiated patients received curative or palliative intent PIB for a recurrent pelvic malignancy between January 2009 and August 2016. Minimum follow-up was 6 months after the PIB procedure...
August 26, 2017: International Journal of Radiation Oncology, Biology, Physics
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