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https://www.readbyqxmd.com/read/29665578/brain-morphology-cognition-and-%C3%AE-amyloid-in-older-adults-with-superior-memory-performance
#1
Theresa M Harrison, Anne Maass, Suzanne L Baker, William J Jagust
The mechanisms underlying superior cognitive performance in some older adults are poorly understood. We used a multimodal approach to characterize imaging and cognitive features of 26 successful agers (SA; defined by superior episodic memory ability) and 103 typical older adults. Cortical thickness was greater in multiple regions in SA including right anterior cingulate and prefrontal cortex and was related to baseline memory performance. Similarly, hippocampal volume was greater in SA and associated with baseline memory...
March 27, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29665066/serotonin-beta-amyloid-and-cognition-in-parkinson-disease
#2
Vikas Kotagal, Cathie Spino, Nicolaas I Bohnen, Robert A Koeppe, Roger L Albin
OBJECTIVE: Serotoninergic neurotransmission may modulate beta-amyloid peptide (Aβ) metabolism through up-regulation of alpha-secretase. Early Parkinson disease (PD) shows variable serotoninergic denervation, which may impact Aβ deposition. METHODS: We conducted three analyses to explore associations between serotoninergic neurotransmission and cerebral Aβ burden in PD. The first was a cross-sectional imaging study of PD subjects (n=23) using the serotoninergic transporter positron emission tomography (PET) ligand [11 C]DASB and amyloid PET Pittsburgh compound B ([11 C]PiB)...
April 17, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29626786/dynamics-of-dual-fluorescent-polymersomes-with-durable-integrity-in-living-cancer-cells-and-zebrafish-embryos
#3
Sven H C Askes, Nelli Bossert, Jeroen Bussmann, Victorio Saez Talens, Michael S Meijer, Roxanne E Kieltyka, Alexander Kros, Sylvestre Bonnet, Doris Heinrich
The long-term fate of biomedical nanoparticles after endocytosis is often only sparsely addressed in vitro and in vivo, while this is a crucial parameter to conclude on their utility. In this study, dual-fluorescent polyisobutylene-polyethylene glycol (PiB-PEG) polymersomes were studied for several days in vitro and in vivo. In order to optically track the vesicles' integrity, one fluorescent probe was located in the membrane and the other in the aqueous interior compartment. These non-toxic nanovesicles were quickly endocytosed in living A549 lung carcinoma cells but unusually slowly transported to perinuclear lysosomal compartments, where they remained intact and luminescent for at least 90 h without being exocytosed...
March 22, 2018: Biomaterials
https://www.readbyqxmd.com/read/29623037/early-life-cognitive-activity-is-related-to-reduced-neurodegeneration-in-alzheimer-signature-regions-in-late-life
#4
Kang Ko, Min Soo Byun, Dahyun Yi, Jun Ho Lee, Chan Hyung Kim, Dong Young Lee
Background: Although increased cognitive activity (CA), both current and past, is known to be associated with a decreased occurrence of Alzheimer's disease (AD) dementia in older adults, the exact neural mechanisms underlying the association between CA during different stages of life and human dementia remain unclear. Therefore, we investigated whether CA during different life stages is associated with cerebral amyloid-beta (Aβ) pathology and AD-related neurodegeneration in non-demented older adults. Methods: Cross-sectional analyses of data collected between April 2014 and March 2016 from the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease (KBASE), an ongoing prospective cohort...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29619853/multi-modality-molecular-imaging-characteristics-of-dementia-with-lewy-bodies
#5
Zhong-Bao Gao, Wei Wang, Xing-Li Zhao, Tong Chen, Li-Ping Fu, Bai-Xuan Xu, Zhen-Fu Wang
Objective Dementia with Lewy bodies (DLB) is a common type of neurodegenerative dementia. Molecular neuroimaging using dopamine transporter (DaT), Pittsburgh compound B (PIB), and fluorodeoxyglucose (FDG) positron emission tomography (PET) has advantages in detecting dopaminergic neuron loss, abnormal amyloid β-protein deposition, and glucose metabolism changes in patients with neurodegenerative disorders. However, the multi-modality molecular imaging features of patients with DLB have rarely been reported...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29615677/longitudinal-outcomes-of-amyloid-positive-versus-negative-amnestic-mild-cognitive-impairments-a-three-year-longitudinal-study
#6
Byoung Seok Ye, Hee Jin Kim, Yeo Jin Kim, Na-Yeon Jung, Jin San Lee, Juyoun Lee, Young Kyoung Jang, Jin-Ju Yang, Jong-Min Lee, Jacob W Vogel, Duk L Na, Sang Won Seo
We aimed to compare the longitudinal outcome of amnestic mild cognitive impairment (aMCI) patients with significant Pittsburgh Compound B uptake [PiB(+) aMCI] and those without [PiB(-) aMCI]. Cerebral β-amyloid was measured in 47 patients with aMCI using PiB-positron emission tomography (PET) (31 PiB(+) aMCI and 16 PiB(-) aMCI). Clinical (N = 47) and neuropsychological follow-up (N = 37), and follow-up with brain magnetic resonance imaging (N = 38) and PiB-PET (N = 30) were performed for three years...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614678/odor-identification-ability-predicts-pet-amyloid-status-and-memory-decline-in-older-adults
#7
William Charles Kreisl, Peng Jin, Seonjoo Lee, Ezra R Dayan, Shankar Vallabhajosula, Gregory Pelton, José A Luchsinger, Gnanavalli Pradhaban, D P Devanand
BACKGROUND: Odor identification deficits occur in Alzheimer's disease (AD), as measured by the 40-item University of Pennsylvania Smell Identification Test (UPSIT). OBJECTIVE: To determine if UPSIT scores predict amyloid-β (Aβ) status, determined by 11C-Pittsburgh Compound B PET. We also compared UPSIT scores to Aβ status in predicting future memory decline. METHODS: Subjects were recruited into a longitudinal clinical prediction study...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29614642/negative-11c-pib-pet-predicts-lack-of-alzheimer-s-disease-pathology-in-postmortem-examination
#8
Noora M Scheinin, Maria Gardberg, Matias Röyttä, Juha O Rinne
Our aim was to assess whether in vivo11C-PIB negative memory-impaired subjects may nonetheless exhibit brain Alzheimer's disease (AD) pathology. We re-evaluated the PET images and systematically characterized the postmortem neuropathology of six individuals who had undergone clinically indicated amyloid PET. The single case with negligible amyloid-β (Aβ) pathology had Lewy body disease, where concomitant AD changes are often seen. Further, the subject's plaques were predominantly diffuse. The predictive value of a negative 11C-PIB scan appears to be good, even in memory-impaired populations...
March 24, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29608645/distinct-dynamic-profiles-of-microglial-activation-are-associated-with-progression-of-alzheimer-s-disease
#9
Lorraine Hamelin, Julien Lagarde, Guillaume Dorothée, Marie Claude Potier, Fabian Corlier, Bertrand Kuhnast, Fabien Caillé, Bruno Dubois, Ludovic Fillon, Marie Chupin, Michel Bottlaender, Marie Sarazin
Although brain neuroinflammation may play an instrumental role in the pathophysiology of Alzheimer's disease, its actual impact on disease progression remains controversial, being reported as either detrimental or protective. This work aimed at investigating the temporal relationship between microglial activation and clinical progression of Alzheimer's disease. First, in a large cohort of patients with Alzheimer's disease we analysed the predictive value of microglial activation assessed by 18F-DPA-714 PET imaging on functional, cognitive and MRI biomarkers outcomes after a 2-year follow-up...
March 28, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29604980/imaging-studies-of-the-hiv-infected-brain
#10
Linda Chang, Dinesh K Shukla
Human immunodeficiency virus (HIV) enters the brain early after infecting humans and may remain in the central nervous system despite successful antiretroviral treatment. Many neuroimaging techniques were used to study HIV+ patients with or without opportunistic infections. These techniques assessed abnormalities in brain structures (using computed tomography, structural magnetic resonance imaging (MRI), diffusion MRI) and function (using functional MRI at rest or during a task, and perfusion MRI with or without a contrast agent)...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29601133/all-optical-switching-and-two-states-light-controlled-coherent-incoherent-random-lasing-in-thiophene-based-donor-acceptor
#11
Adam Szukalski, Awatef Ayadi, Karolina Haupa, Abdelkrim El-Ghayoury, Bouchta Sahraoui, Jaroslaw Mysliwiec
We describe herein the synthesis and characterization of a thiophene based donor acceptor system, namely (E)-2-(4-nitrostyryl)-5-phenylthiophene (Th-pNO2) that was prepared under Horner-Wadsworth-Emmons conditions. The UV-visible absorption bands, including the intramolecular charge transfer (ICT) band, were fully assigned using DFT and TD-DFT computations. Results of both efficient 3rd order nonlinear optical properties and light amplification phenomenon are presented. Investigation of photoinduced birefringence (PIB) in optical Kerr effect (OKE) experiment showed a great potential for this particular compound as efficient, fully reversible and fast optical switch...
March 30, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29589208/significance-of-11-c-pib-pet-ct-in-cardiac-amyloidosis-compared-with-99m-tc-aprotinin-scintigraphy-a-pilot-study
#12
Ryogo Minamimoto, Toru Awaya, Kentaro Iwama, Masatoshi Hotta, Kazuhiko Nakajima, Risen Hirai, Osamu Okazaki, Yukio Hiroi
BACKGROUND: This study was to investigate the significance of11 C-Pittsburgh B (PIB) PET/CT in patients with suspected cardiac amyloidosis compared with99m Tc-aprotinin scintigraphy. METHODS: Thirteen consecutive patients with suspected cardiac amyloidosis were considered for enrolment in this prospective pilot study. Participants were scheduled to undergo a series of11 C-PIB PET/CT and99m Tc-aprotinin within a 2-month period. Finally, we evaluated nine cases who underwent both imaging modalities, and compared imaging results with clinical and pathological results and prognosis...
March 27, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29577020/functionalised-carbon-nanotubes-enhance-brain-delivery-of-amyloid-targeting-pittsburgh-compound-b-pib-derived-ligands
#13
Pedro Miguel Costa, Julie Tzu-Wen Wang, Jean-François Morfin, Tamanna Khanum, Wan To, Jane Sosabowski, Eva Tóth, Khuloud T Al-Jamal
Alzheimer's disease (AD) is a neurodegenerative disorder characterised by brain accumulation of toxic protein aggregates, including extracellular amyloid beta (Aβ) plaques, inflammation, neuronal death and progressive cognitive dysfunction. Current diagnostic modalities, based on cognitive tests, fail to detect early AD onset, thus emphasising the need to develop improved methods for pre-symptomatic disease detection. Building on the properties of the Pittsburgh Compound B (PiB), an Aβ-binding molecule suitable to use as positron emission tomography (PET) imaging agent, and aiming at using a more clinically available modality (like magnetic ressonance imaging, MRI), PiB derivatives have been conjugated to the macrocyclic chelator 1,4,7-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane (DO3A) monoamide...
2018: Nanotheranostics
https://www.readbyqxmd.com/read/29562849/does-positive-illusory-bias-affect-self-concept-and-loneliness-in-children-with-symptoms-of-adhd
#14
Agnese Capodieci, Giulia Crisci, Irene Cristina Mammarella
OBJECTIVE: Positive illusory bias (PIB) has been amply studied in children with ADHD, but its function is still limited understanding. METHOD: In a sample of 21 children with symptoms of ADHD, this study investigated whether they were more likely to be rejected by peers and examined PIB, and its influence on self-concept and loneliness, comparing the children with symptoms of ADHD with children who had weak social skills, but no ADHD. The children's and teachers' perception of social difficulties were compared, and self-concept and loneliness were analyzed in the two groups, which were also compared with typically developing (TD) children...
March 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29546794/corrigendum
#15
(no author information available yet)
Grecchi E, Veronese M, Bodini B, et al. Multimodal partial volume correction: Application to [11C]PIB PET/MRI myelin imaging in multiple sclerosis. J Cereb Blood Flow Metab 2017; 37: 3803-3817. The label to Figure 1 in the above article should have read 'Myelin Sheath', not 'Myelin Sheat'. The figure with the correct label appears below. This error also appeared on the reproduction of the figure on the cover of the December 2017 issue of the journal, volume 37, issue 12.
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29546632/amyloid-load-but-not-regional-glucose-metabolism-predicts-conversion-to-alzheimer-s-dementia-in-a-memory-clinic-population
#16
Lars Frings, Sabine Hellwig, Tobias Bormann, Timo S Spehl, Ralph Buchert, Philipp T Meyer
PURPOSE: The value of imaging regional glucose metabolism with [18 F]FDG PET for the prediction of progression from mild cognitive impairment (MCI) to Alzheimer's dementia (AD) is controversial. The predictive value of imaging with [18 F]FDG PET was therefore tested and compared with that of imaging beta-amyloid load with [11 C]PIB PET in the same memory clinic population of MCI patients. METHODS: Thirty-nine patients with MCI who had undergone [18 F]FDG as well as [11 C]PIB PET were identified from a single-centre clinical registry...
March 15, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29543355/detection-and-imaging-of-a%C3%AE-1-42-and-tau-fibrils-by-redesigned-fluorescent-x-34-analogues
#17
Jun Zhang, Alexander Sandberg, Audun Konsmo, Xiongyu Wu, Sofie Nyström, K Peter Nilsson, Peter Konradsson, Harry LeVine, Mikael Lindgren, Per Hammarström
We revisited the Congo red analogue 2,5-bis(4'-hydroxy-3'-carboxy-styryl)benzene (X-34) to develop this highly fluorescent amyloid dye for imaging Alzheimer's disease (AD) pathology comprising Aβ and Tau fibrils. A selection of ligands with distinct optical properties were synthesized by replacing the central benzene unit of X-34, with other heterocyclic moieties. Full photophysical characterization was performed determining absorbance and fluorescence spectra, Stokes shift, quantum yield and fluorescence lifetimes...
March 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29533709/erratum
#18
(no author information available yet)
Grecchi E, Veronese M, Bodini B, et al. Multimodal partial volume correction: Application to [11C]PIB PET/MRI myelin imaging in multiple sclerosis. J Cereb Blood Flow Metab 2017; 37: 3803-3817. Three references in the above article appeared with typesetting coding when published online and in print. The references should have appeared as follows: 8. Aston JAD, Cunningham VJ, Asselin M-C, et al. Positron emission tomography partial volume correction: estimation and algorithms. J Cereb Blood Flow Metab 2002; 22: 1019-1034...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29532057/association-of-excessive-daytime-sleepiness-with-longitudinal-%C3%AE-amyloid-accumulation-in-elderly-persons-without-dementia
#19
Diego Z Carvalho, Erik K St Louis, David S Knopman, Bradley F Boeve, Val J Lowe, Rosebud O Roberts, Michelle M Mielke, Scott A Przybelski, Mary M Machulda, Ronald C Petersen, Clifford R Jack, Prashanthi Vemuri
Importance: Aging is associated with excessive daytime sleepiness (EDS), which has been linked to cognitive decline in the elderly. However, whether EDS is associated with the pathologic processes of Alzheimer disease remains unclear. Objective: To investigate whether EDS at baseline is associated with a longitudinal increase in regional β-amyloid (Aβ) accumulation in a cohort of elderly individuals without dementia. Design, Setting, and Participants: This prospective analysis included participants enrolled in the Mayo Clinic Study of Aging, a longitudinal population-based study in Olmsted County, Minnesota...
March 12, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29531506/brain-network-alterations-in-alzheimer-s-disease-identified-by-early-phase-pib-pet
#20
Liping Fu, Linwen Liu, Jinming Zhang, Baixuan Xu, Yong Fan, Jiahe Tian
The aim of this study was to identify the brain networks from early-phase 11 C-PIB (perfusion PIB, pPIB) data and to compare the brain networks of patients with differentiating Alzheimer's disease (AD) with cognitively normal subjects (CN) and of mild cognitively impaired patients (MCI) with CN. Forty participants (14 CN, 12 MCI, and 14 AD) underwent 11 C-PIB and 18 F-FDG PET/CT scans. Parallel independent component analysis (pICA) was used to identify correlated brain networks from the 11 C-pPIB and 18 F-FDG data, and a two-sample t -test was used to evaluate group differences in the corrected brain networks between AD and CN, and between MCI and CN...
2018: Contrast Media & Molecular Imaging
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