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https://www.readbyqxmd.com/read/28211269/phosphorus-based-alloy-materials-for-advanced-potassium-ion-battery-anode
#1
Wenchao Zhang, Jianfeng Mao, Sean Li, Zhixin Chen, Zaiping Guo
Potassium-ion batteries (PIBs) are interesting as one of the alternative metal-ion battery systems to lithium-ion batteries (LIBs) due to the abundance and low cost of potassium. We have herein investigated Sn4P3/C composite as a novel anode material for PIBs. The electrode delivered a reversible capacity of 384.8 mA h g-1 at 50 mA g-1 and a good rate capability of 221.9 mA h g-1, even at 1 A g-1. Its electrochemical performance is better than any anode material reported so far for PIBs. It was also found that the Sn4P3/C electrode displays a discharge potential plateau of 0...
February 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28206782/process-dissociation-analyses-of-memory-changes-in-healthy-aging-preclinical-and-very-mild-alzheimer-disease-evidence-for-isolated-recollection-deficits
#2
Peter R Millar, David A Balota, Geoffrey B Maddox, Janet M Duchek, Andrew J Aschenbrenner, Anne M Fagan, Tammie L S Benzinger, John C Morris
OBJECTIVE: Recollection and familiarity are independent processes that contribute to memory performance. Recollection is dependent on attentional control, which has been shown to be disrupted in early stage Alzheimer's disease (AD), whereas familiarity is independent of attention. The present longitudinal study examines the sensitivity of recollection estimates based on Jacoby's (1991) process dissociation procedure to AD-related biomarkers in a large sample of well-characterized cognitively normal middle-aged and older adults (N = 519) and the extent to which recollection discriminates these individuals from individuals with very mild symptomatic AD (N = 64)...
February 16, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28192686/the-down-syndrome-brain-in-the-presence-and-absence-of-fibrillar-%C3%AE-amyloidosis
#3
Tiina Annus, Liam R Wilson, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Young T Hong, Tim D Fryer, Jonathan P Coles, David K Menon, Shahid H Zaman, Anthony J Holland, Peter J Nestor
People with Down syndrome (DS) have a neurodevelopmentally distinct brain and invariably developed amyloid neuropathology by age 50. This cross-sectional study aimed to provide a detailed account of DS brain morphology and the changes occuring with amyloid neuropathology. Forty-six adults with DS underwent structural and amyloid imaging-the latter using Pittsburgh compound B (PIB) to stratify the cohort into PIB-positive (n = 19) and PIB-negative (n = 27). Age-matched controls (n = 30) underwent structural imaging...
January 17, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28177283/hippocampal-activation-is-associated-with-longitudinal-amyloid-accumulation-and-cognitive-decline
#4
Stephanie L Leal, Susan M Landau, Rachel K Bell, William J Jagust
The amyloid hypothesis suggests that beta-amyloid (Aβ) deposition leads to alterations in neural function and ultimately to cognitive decline in Alzheimer's disease. However, factors that underlie Aβ deposition are incompletely understood. One proposed model suggests that synaptic activity leads to increased Aβ deposition. More specifically, hyperactivity in the hippocampus may be detrimental and could be one factor that drives Aβ deposition. To test this model, we examined the relationship between hippocampal activity during a memory task using fMRI and subsequent longitudinal change in Aβ using PIB-PET imaging in cognitively normal older adults...
February 8, 2017: ELife
https://www.readbyqxmd.com/read/28161156/amyloid-beta-deposition-is-associated-with-increased-medial-temporal-lobe-activation-during-memory-encoding-in-the-cognitively-normal-elderly
#5
Kathryn Edelman, Dana Tudorascu, Christian Agudelo, Beth Snitz, Helmet Karim, Ann Cohen, Chester Mathis, Julie Price, Lisa Weissfeld, William Klunk, Howard Aizenstein
BACKGROUND: Much is unknown about changes that occur in the brain in the years preceding the cognitive and functional impairment associated with Alzheimer disease (AD). This period before mild cognitive impairment is present has been referred to as preclinical AD, and is thought to begin with amyloid-beta deposition and then progress to neurodegeneration and functional brain circuit alterations. Prior studies have shown that there is increased medial temporal lobe activation on functional magnetic resonance imaging (fMRI) early in the course of mild cognitive impairment...
January 19, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28139423/outpatient-template-guided-permanent-interstitial-brachytherapy-using-131-cs-in-gynecologic-malignancies-initial-report
#6
Jonathan Feddock, Prakash Aryal, Cole Steber, Jason Edwards, Dennis Cheek, Marcus Randall
PURPOSE: Optimal curative intent brachytherapy for certain gynecologic cancers requires interstitial brachytherapy, often using template-guided techniques such as a Syed-Neblett implant. Whether high or low dose rate (LDR), these procedures pose significant risks to patients, partly attributable to the prolonged period of bed rest. Published results of free-handed permanent interstitial brachytherapy (PIB) with (131)Cs demonstrate it to be an effective modality for the management of small volume gynecologic cancers...
January 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28138509/association-between-a%C3%AE-and-tau-accumulations-and-their-influence-on-clinical-features-in-aging-and-alzheimer-s-disease-spectrum-brains-a-11-c-pbb3-pet-study
#7
Hitoshi Shimada, Soichiro Kitamura, Hitoshi Shinotoh, Hironobu Endo, Fumitoshi Niwa, Shigeki Hirano, Yasuyuki Kimura, Ming-Rong Zhang, Satoshi Kuwabara, Tetsuya Suhara, Makoto Higuchi
INTRODUCTION: Amyloid-β (Aβ) and tau accumulations may occur independently and concurrently as exemplified by primary age-related tauopathy and Alzheimer's disease (AD), respectively. Interactions between Aβ and tau accumulations and their influence on clinical features, however, are still unclear. METHODS: Associations among clinical symptoms, gray-matter volume, regional tau, and Aβ deposition assessed by positron emission tomography with [(11)C]pyridinyl-butadienyl-benzothiazole 3 (PBB3) and [(11)C]Pittsburgh compound-B (PiB), were evaluated in 17 AD, 9 mild cognitive impairment due to AD, and 28 PiB(-)-cognitive healthy controls (HCs)...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28128852/glecaprevir-and-pibrentasvir-for-12-weeks-for-hcv-genotype-1-infection-and-prior-direct-acting-antiviral-treatment
#8
Fred Poordad, Franco Felizarta, Armen Asatryan, Mark S Sulkowski, Robert W Reindollar, Charles S Landis, Stuart C Gordon, Steven L Flamm, Michael W Fried, David E Bernstein, Chih-Wei Lin, Ran Liu, Sandra S Lovell, Teresa I Ng, Jens Kort, Federico J Mensa
: Although direct-acting antiviral (DAA) therapies for chronic hepatitis C virus (HCV) infection have demonstrated high rates of sustained virologic response, virologic failure may still occur, potentially leading to the emergence of viral resistance, which can decrease the effectiveness of subsequent treatment. Treatment options for patients who failed previous DAA-containing regimens, particularly those with NS5A inhibitors, are limited, and remain an area of unmet medical need. This phase 2, open-label study (MAGELLAN-1) evaluated the efficacy and safety of glecaprevir (GLE) + pibrentasvir (PIB) ± ribavirin (RBV) in HCV genotype 1-infected patients with prior virologic failure to HCV DAA-containing therapy...
January 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28122877/an-early-and-late-peak-in-microglial-activation-in-alzheimer-s-disease-trajectory
#9
Zhen Fan, David J Brooks, Aren Okello, Paul Edison
Amyloid-β deposition, neuroinflammation and tau tangle formation all play a significant role in Alzheimer's disease. We hypothesized that there is microglial activation early on in Alzheimer's disease trajectory, where in the initial phase, microglia may be trying to repair the damage, while later on in the disease these microglia could be ineffective and produce proinflammatory cytokines leading to progressive neuronal damage. In this longitudinal study, we have evaluated the temporal profile of microglial activation and its relationship between fibrillar amyloid load at baseline and follow-up in subjects with mild cognitive impairment, and this was compared with subjects with Alzheimer's disease...
January 24, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28111810/mutual-effect-of-cerebral-amyloid-%C3%AE-and-peripheral-lymphocytes-in-cognitively-normal-older-individuals
#10
Fumihiko Yasuno, Hiroaki Kazui, Katsufumi Kajimoto, Masafumi Ihara, Naomi Morita, Akihiko Taguchi, Akihide Yamamoto, Kiwamu Matsuoka, Masato Takahashi, Jyoji Nakagawara, Masahito Tsuji, Hidehiro Iida, Toshifumi Kishimoto, Kazuyuki Nagatsuka
OBJECTIVE: We hypothesized that cerebral amyloid accumulation is reflected in the periphery in the pre-dementia stage and used flow cytometry to investigate the peripheral lymphocytes as an easily accessible biomarker to observe neuro-inflammation. We aimed to determine whether peripheral lymphocytes are related to the cortical amyloid burden or vice versa in cognitively normal older subjects. METHODS: We applied [(11) C] Pittsburgh compound B (PiB)-positron emission tomography to 36 cognitively normal older individuals, and Aβ deposition was quantified by cortical binding potential (PiB-BPND )...
January 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28106566/cerebral-amyloid-burden-and-hoehn-and-yahr-stage-3-scoring-in-parkinson-disease
#11
Vikas Kotagal, Nicolaas I Bohnen, Martijn L T M Müller, Kirk A Frey, Roger L Albin
BACKGROUND: Progression to Hoehn and Yahr (HY) stage 3 marks the transition to advanced disease staging and disability in Parkinson disease (PD). OBJECTIVE/METHODS: We conducted a case-control study of 36 PD subjects at HY stage 2.5 or 3, with groups matched for gender, age, and disease duration. Positron Emission tomography (PET) imaging included dihydrotetrabenazine [11C]DTBZ and Pittsburgh Compound B [11C]PiB. RESULTS: Subjects with HY 2...
January 17, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28097205/impact-of-tau-and-amyloid-burden-on-glucose-metabolism-in-alzheimer-s-disease
#12
Gérard N Bischof, Frank Jessen, Klaus Fliessbach, Julian Dronse, Jochen Hammes, Bernd Neumaier, Oezguer Onur, Gereon R Fink, Juraj Kukolja, Alexander Drzezga, Thilo van Eimeren
In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [(18)F]AV-1451) and beta-amyloid burden (measured with [(11)C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [(18)F]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism...
December 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28064175/neuroimaging-of-inflammation-in-memory-and-related-other-disorders-nimrod-study-protocol-a-deep-phenotyping-cohort-study-of-the-role-of-brain-inflammation-in-dementia-depression-and-other-neurological-illnesses
#13
W Richard Bevan-Jones, Ajenthan Surendranathan, Luca Passamonti, Patricia Vázquez Rodríguez, Robert Arnold, Elijah Mak, Li Su, Jonathan P Coles, Tim D Fryer, Young T Hong, Guy Williams, Franklin Aigbirhio, James B Rowe, John T O'Brien
INTRODUCTION: Inflammation of the central nervous system is increasingly regarded as having a role in cognitive disorders such as dementia and depression, but it is not clear how such inflammation relates to other aspects of neuropathology, structural and functional changes in the brain and symptoms (as assessed via clinical and neuropsychological assessment and MRI). This study will explore these pathophysiological mechanisms using positron emission tomography (PET) which allows in vivo imaging of inflammation, amyloid and τ deposition, together with neuropsychological profiling, MRI and peripheral biomarker analysis...
January 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28062596/prediction-of-the-clinical-standardized-uptake-value-ratio-in-amyloid-pet-imaging-using-a-biomathematical-modeling-approach-towards-the-efficient-development-of-a-radioligand
#14
Yuma Arakawa, YingHwey Nai, Miho Shidahara, Shozo Furumoto, Chie Seki, Nobuyuki Okamura, Manabu Tashiro, Yukitsuka Kudo, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe
OBJECTIVE: Our study aimed to develop a method to mathematically predict the kinetic parameters K1, k2 and BPND of amyloid PET tracers, and finally obtain standardized uptake value ratio (SUVR) values from predicted time-activity curves (TACs) of target and reference regions. METHODS: Ten clinically applied amyloid PET radioligands, (11)C-PIB, (11)C-BF-227, (11)C-AZD2184, (11)C-SB-13, (18)F-FACT, (18)F-Florbetapir, (18)F-Florbetaben, (18)F-Flutemetamol, (18)F-FDDNP and (18)F-AZD4694, were investigated...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28012047/the-protective-mechanism-of-qgc-in-feline-esophageal-epithelial-cells-by-interleukin-1%C3%AE-treatment
#15
Hyun Soo Jang, Seung In Um, Sung Hee Lee, Wan Kyunn Whang, Young Sil Min, Sun Young Park, Uy Dong Sohn
In a previous study, Quercetin-3-O-β-D-glucuronopyranoside (QGC) has anti-oxidative and anti-inflammatory effects in vivo. QGC is a flavonoid glucoside extracted from Rumex Aquaticus. We investigated the downstream target proteins involved in IL-1β-stimulated ROS production and the ability of QGC to inhibit ROS production. Cell viability was determined using the MTT reduction assay. Western blot analysis was performed with antibodies to investigate the activation of three MAPKs, NF-κB, and phosphorylated IκB-α (pIB), and the expression of COX-2...
December 23, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28004285/is-the-positive-illusory-bias-common-in-young-adolescents-with-adhd-a-fresh-look-at-prevalence-and-stability-using-latent-profile-and-transition-analyses
#16
Elizaveta Bourchtein, Joshua M Langberg, Julie S Owens, Steven W Evans, Robert A Perera
The goal of this study was to use novel approaches that do not require the use of arbitrary cut-points (i.e., latent profile/transition analysis) to evaluate the prevalence and stability of the positive illusory bias (PIB) in young adolescents with attention-deficit/hyperactivity disorder (ADHD). Participants were 326 middle-school students diagnosed with ADHD (Mage = 12.26 years, 71% male, 77% Caucasian). The Self-Perception Profile for Children (SPPC) was completed by participants and their parents at baseline and again 12 and 18 months later...
December 21, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28003959/use-of-t1-weighted-t2-weighted-magnetic-resonance-ratio-to-elucidate-changes-due-to-amyloid-%C3%AE-accumulation-in-cognitively-normal-subjects
#17
Fumihiko Yasuno, Hiroaki Kazui, Naomi Morita, Katsufumi Kajimoto, Masafumi Ihara, Akihiko Taguchi, Akihide Yamamoto, Kiwamu Matsuoka, Masato Takahashi, Jyoji Nakagawara, Hidehiro Iida, Toshifumi Kishimoto, Kazuyuki Nagatsuka
The ratio of signal intensity in T1-weighted (T1w) and T2-weighted (T2w) magnetic resonance imaging (MRI) was recently proposed to enhance the sensitivity of detecting changes in disease-related signal intensity. The objective of this study was to test the effectiveness of T1w/T2w image ratios as an easily accessible biomarker for amyloid beta (Aβ) accumulation. We performed the T1w/T2w analysis in cognitively normal elderly individuals. We applied [(11)C] Pittsburgh Compound B (PiB)-PET to the same individuals, and Aβ deposition was quantified by its binding potential (PiB-BPND)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27998017/nanogel-based-scaffolds-fabricated-for-bone-regeneration-with-mesoporous-bioactive-glass-and-strontium-in-vitro-and-in-vivo-characterization
#18
Qiao Zhang, Xiaohui Chen, Shinan Geng, Lingfei Wei, Richard J Miron, Yanbing Zhao, Yufeng Zhang
The delivery of novel bioactive scaffolds for the repair of bone defects remains a prominent challenge worldwide. Currently osteoporosis, a disease caused by low bone mineral density affects over 200 million people worldwide with up to half of this population experiencing at least 1 fracture within their lifetime. Recently Temperature-Sensitive p(N-Isopropylacrylamide-co-butyl Methylacrylate) nanogel(PIB nanogel) scaffolds have emerged as biomaterial candidate for regenerative therapies. It has the advantage of being injected from syringes as a soluble gel form(capable of delivering growth and/or living progenitor cells) yet hardens once it reaches body temperatures...
December 20, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27995509/the-evaluation-of-growth-and-phytoextraction-potential-of-miscanthus-x-giganteus-and-sida-hermaphrodita-on-soil-contaminated-simultaneously-with-cd-cu-ni-pb-and-zn
#19
Anna Kocoń, Beata Jurga
One of the cheapest, environmentally friendly methods for cleaning an environment polluted by heavy metals is phytoextraction. It builds on the uptake of pollutants from the soil by the plants, which are able to grow under conditions of high concentrations of toxic metals. The aim of this work was to assess the possibility of growing and phytoextraction potential of Miscanthus x giganteus and Sida hermaphrodita cultivated on two different soils contaminated with five heavy metals simultaneously: Cd, Cu, Ni, Pb, and Zn...
December 19, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27995065/classification-of-amyloid-status-using-machine-learning-with-histograms-of-oriented-3d-gradients
#20
Liam Cattell, Günther Platsch, Richie Pfeiffer, Jérôme Declerck, Julia A Schnabel, Chloe Hutton
Brain amyloid burden may be quantitatively assessed from positron emission tomography imaging using standardised uptake value ratios. Using these ratios as an adjunct to visual image assessment has been shown to improve inter-reader reliability, however, the amyloid positivity threshold is dependent on the tracer and specific image regions used to calculate the uptake ratio. To address this problem, we propose a machine learning approach to amyloid status classification, which is independent of tracer and does not require a specific set of regions of interest...
2016: NeuroImage: Clinical
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