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https://www.readbyqxmd.com/read/28106566/cerebral-amyloid-burden-and-hoehn-and-yahr-stage-3-scoring-in-parkinson-disease
#1
Vikas Kotagal, Nicolaas I Bohnen, Martijn L T M Müller, Kirk A Frey, Roger L Albin
BACKGROUND: Progression to Hoehn and Yahr (HY) stage 3 marks the transition to advanced disease staging and disability in Parkinson disease (PD). OBJECTIVE/METHODS: We conducted a case-control study of 36 PD subjects at HY stage 2.5 or 3, with groups matched for gender, age, and disease duration. Positron Emission tomography (PET) imaging included dihydrotetrabenazine [11C]DTBZ and Pittsburgh Compound B [11C]PiB. RESULTS: Subjects with HY 2...
January 17, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28097205/impact-of-tau-and-amyloid-burden-on-glucose-metabolism-in-alzheimer-s-disease
#2
Gérard N Bischof, Frank Jessen, Klaus Fliessbach, Julian Dronse, Jochen Hammes, Bernd Neumaier, Oezguer Onur, Gereon R Fink, Juraj Kukolja, Alexander Drzezga, Thilo van Eimeren
In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [(18)F]AV-1451) and beta-amyloid burden (measured with [(11)C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [(18)F]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism...
December 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28064175/neuroimaging-of-inflammation-in-memory-and-related-other-disorders-nimrod-study-protocol-a-deep-phenotyping-cohort-study-of-the-role-of-brain-inflammation-in-dementia-depression-and-other-neurological-illnesses
#3
W Richard Bevan-Jones, Ajenthan Surendranathan, Luca Passamonti, Patricia Vázquez Rodríguez, Robert Arnold, Elijah Mak, Li Su, Jonathan P Coles, Tim D Fryer, Young T Hong, Guy Williams, Franklin Aigbirhio, James B Rowe, John T O'Brien
INTRODUCTION: Inflammation of the central nervous system is increasingly regarded as having a role in cognitive disorders such as dementia and depression, but it is not clear how such inflammation relates to other aspects of neuropathology, structural and functional changes in the brain and symptoms (as assessed via clinical and neuropsychological assessment and MRI). This study will explore these pathophysiological mechanisms using positron emission tomography (PET) which allows in vivo imaging of inflammation, amyloid and τ deposition, together with neuropsychological profiling, MRI and peripheral biomarker analysis...
January 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28062596/prediction-of-the-clinical-standardized-uptake-value-ratio-in-amyloid-pet-imaging-using-a-biomathematical-modeling-approach-towards-the-efficient-development-of-a-radioligand
#4
Yuma Arakawa, YingHwey Nai, Miho Shidahara, Shozo Furumoto, Chie Seki, Nobuyuki Okamura, Manabu Tashiro, Yukitsuka Kudo, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe
OBJECTIVE: Our study aimed to develop a method to mathematically predict the kinetic parameters K1, k2 and BPND of amyloid PET tracers, and finally obtain standardized uptake value ratio (SUVR) values from predicted time-activity curves (TACs) of target and reference regions. METHODS: Ten clinically applied amyloid PET radioligands, (11)C-PIB, (11)C-BF-227, (11)C-AZD2184, (11)C-SB-13, (18)F-FACT, (18)F-Florbetapir, (18)F-Florbetaben, (18)F-Flutemetamol, (18)F-FDDNP and (18)F-AZD4694, were investigated...
January 6, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28012047/the-protective-mechanism-of-qgc-in-feline-esophageal-epithelial-cells-by-interleukin-1%C3%AE-treatment
#5
Hyun Soo Jang, Seung In Um, Sung Hee Lee, Wan Kyunn Whang, Young Sil Min, Sun Young Park, Uy Dong Sohn
In a previous study, Quercetin-3-O-β-D-glucuronopyranoside (QGC) has anti-oxidative and anti-inflammatory effects in vivo. QGC is a flavonoid glucoside extracted from Rumex Aquaticus. We investigated the downstream target proteins involved in IL-1β-stimulated ROS production and the ability of QGC to inhibit ROS production. Cell viability was determined using the MTT reduction assay. Western blot analysis was performed with antibodies to investigate the activation of three MAPKs, NF-κB, and phosphorylated IκB-α (pIB), and the expression of COX-2...
December 23, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28004285/is-the-positive-illusory-bias-common-in-young-adolescents-with-adhd-a-fresh-look-at-prevalence-and-stability-using-latent-profile-and-transition-analyses
#6
Elizaveta Bourchtein, Joshua M Langberg, Julie S Owens, Steven W Evans, Robert A Perera
The goal of this study was to use novel approaches that do not require the use of arbitrary cut-points (i.e., latent profile/transition analysis) to evaluate the prevalence and stability of the positive illusory bias (PIB) in young adolescents with attention-deficit/hyperactivity disorder (ADHD). Participants were 326 middle-school students diagnosed with ADHD (Mage = 12.26 years, 71% male, 77% Caucasian). The Self-Perception Profile for Children (SPPC) was completed by participants and their parents at baseline and again 12 and 18 months later...
December 21, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28003959/use-of-t1-weighted-t2-weighted-magnetic-resonance-ratio-to-elucidate-changes-due-to-amyloid-%C3%AE-accumulation-in-cognitively-normal-subjects
#7
Fumihiko Yasuno, Hiroaki Kazui, Naomi Morita, Katsufumi Kajimoto, Masafumi Ihara, Akihiko Taguchi, Akihide Yamamoto, Kiwamu Matsuoka, Masato Takahashi, Jyoji Nakagawara, Hidehiro Iida, Toshifumi Kishimoto, Kazuyuki Nagatsuka
The ratio of signal intensity in T1-weighted (T1w) and T2-weighted (T2w) magnetic resonance imaging (MRI) was recently proposed to enhance the sensitivity of detecting changes in disease-related signal intensity. The objective of this study was to test the effectiveness of T1w/T2w image ratios as an easily accessible biomarker for amyloid beta (Aβ) accumulation. We performed the T1w/T2w analysis in cognitively normal elderly individuals. We applied [(11)C] Pittsburgh Compound B (PiB)-PET to the same individuals, and Aβ deposition was quantified by its binding potential (PiB-BPND)...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27998017/nanogel-based-scaffolds-fabricated-for-bone-regeneration-with-mesoporous-bioactive-glass-and-strontium-in-vitro-and-in-vivo-characterization
#8
Qiao Zhang, Xiaohui Chen, Shinan Geng, Lingfei Wei, Richard J Miron, Yanbing Zhao, Yufeng Zhang
The delivery of novel bioactive scaffolds for the repair of bone defects remains a prominent challenge worldwide. Currently osteoporosis, a disease caused by low bone mineral density affects over 200 million people worldwide with up to half of this population experiencing at least 1 fracture within their lifetime. Recently Temperature-Sensitive p(N-Isopropylacrylamide-co-butyl Methylacrylate) nanogel(PIB nanogel) scaffolds have emerged as biomaterial candidate for regenerative therapies. It has the advantage of being injected from syringes as a soluble gel form(capable of delivering growth and/or living progenitor cells) yet hardens once it reaches body temperatures...
December 20, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27995509/the-evaluation-of-growth-and-phytoextraction-potential-of-miscanthus-x-giganteus-and-sida-hermaphrodita-on-soil-contaminated-simultaneously-with-cd-cu-ni-pb-and-zn
#9
Anna Kocoń, Beata Jurga
One of the cheapest, environmentally friendly methods for cleaning an environment polluted by heavy metals is phytoextraction. It builds on the uptake of pollutants from the soil by the plants, which are able to grow under conditions of high concentrations of toxic metals. The aim of this work was to assess the possibility of growing and phytoextraction potential of Miscanthus x giganteus and Sida hermaphrodita cultivated on two different soils contaminated with five heavy metals simultaneously: Cd, Cu, Ni, Pb, and Zn...
December 19, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27995065/classification-of-amyloid-status-using-machine-learning-with-histograms-of-oriented-3d-gradients
#10
Liam Cattell, Günther Platsch, Richie Pfeiffer, Jérôme Declerck, Julia A Schnabel, Chloe Hutton
Brain amyloid burden may be quantitatively assessed from positron emission tomography imaging using standardised uptake value ratios. Using these ratios as an adjunct to visual image assessment has been shown to improve inter-reader reliability, however, the amyloid positivity threshold is dependent on the tracer and specific image regions used to calculate the uptake ratio. To address this problem, we propose a machine learning approach to amyloid status classification, which is independent of tracer and does not require a specific set of regions of interest...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27989773/in-vivo-detection-of-microstructural-correlates-of-brain-pathology-in-preclinical-and-early-alzheimer-disease-with-magnetic-resonance-imaging
#11
Yue Zhao, Marcus E Raichle, Jie Wen, Tammie L Benzinger, Anne M Fagan, Jason Hassenstab, Andrei G Vlassenko, Jie Luo, Nigel J Cairns, Jon J Christensen, John C Morris, Dmitriy A Yablonskiy
BACKGROUND: Alzheimer disease (AD) affects at least 5 million individuals in the USA alone stimulating an intense search for disease prevention and treatment therapies as well as for diagnostic techniques allowing early identification of AD during a long pre-symptomatic period that can be used for the initiation of prevention trials of disease-modifying therapies in asymptomatic individuals. METHODS: Our approach to developing such techniques is based on the Gradient Echo Plural Contrast Imaging (GEPCI) technique that provides quantitative in vivo measurements of several brain-tissue-specific characteristics of the gradient echo MRI signal (GEPCI metrics) that depend on the integrity of brain tissue cellular structure...
December 15, 2016: NeuroImage
https://www.readbyqxmd.com/read/27988322/a-multi-centre-evaluation-of-eleven-clinically-feasible-brain-pet-mri-attenuation-correction-techniques-using-a-large-cohort-of-patients
#12
Claes N Ladefoged, Ian Law, Udunna Anazodo, Keith St Lawrence, David Izquierdo-Garcia, Ciprian Catana, Ninon Burgos, M Jorge Cardoso, Sebastien Ourselin, Brian Hutton, Inés Mérida, Nicolas Costes, Alexander Hammers, Didier Benoit, Søren Holm, Meher Juttukonda, Hongyu An, Jorge Cabello, Mathias Lukas, Stephan Nekolla, Sibylle Ziegler, Matthias Fenchel, Bjoern Jakoby, Michael E Casey, Tammie Benzinger, Liselotte Højgaard, Adam E Hansen, Flemming L Andersen
AIM: To accurately quantify the radioactivity concentration measured by PET, emission data need to be corrected for photon attenuation; however, the MRI signal cannot easily be converted into attenuation values, making attenuation correction (AC) in PET/MRI challenging. In order to further improve the current vendor-implemented MR-AC methods for absolute quantification, a number of prototype methods have been proposed in the literature. These can be categorized into three types: template/atlas-based, segmentation-based, and reconstruction-based...
December 14, 2016: NeuroImage
https://www.readbyqxmd.com/read/27983553/down-syndrome-partial-trisomy-21-and-absence-of-alzheimer-s-disease-the-role-of-app
#13
Eric Doran, David Keator, Elizabeth Head, Michael J Phelan, Ron Kim, Minodora Totoiu, Jorge R Barrio, Gary W Small, Steven G Potkin, Ira T Lott
Overexpression of the amyloid precursor protein (APP) gene on chromosome 21 in Down syndrome (DS) has been linked to increased brain amyloid levels and early-onset Alzheimer's disease (AD). An elderly man with phenotypic DS and partial trisomy of chromosome 21 (PT21) lacked triplication of APP affording an opportunity to study the role of this gene in the pathogenesis of dementia. Multidisciplinary studies between ages 66-72 years comprised neuropsychological testing, independent neurological exams, amyloid PET imaging with 11C-Pittsburgh compound-B (PiB), plasma amyloid-β (Aβ) measurements, and a brain autopsy examination...
December 9, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27981028/regional-correlations-between-11-c-pib-pet-and-post-mortem-burden-of-amyloid-beta-pathology-in-a-diverse-neuropathological-cohort
#14
Sang Won Seo, Nagehan Ayakta, Lea T Grinberg, Sylvia Villeneuve, Manja Lehmann, Bruce Reed, Charles DeCarli, Bruce L Miller, Howard J Rosen, Adam L Boxer, James P O'Neil, Lee-Way Jin, William W Seeley, William J Jagust, Gil D Rabinovici
Imaging-pathological correlation studies show that in vivo amyloid-β (Aβ) positron emission tomography (PET) strongly predicts the presence of significant Aβ pathology at autopsy. We sought to determine whether regional PiB-PET uptake would improve sensitivity for amyloid detection in comparison with global measures (experiment 1), and to estimate the relative contributions of different Aβ aggregates to in vivo PET signal (experiment 2). In experiment 1, 54 subjects with [(11)C] PiB-PET during life and postmortem neuropathologic examination (85...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27966045/inter-rater-variability-of-visual-interpretation-and-comparison-with-quantitative-evaluation-of-11-c-pib-pet-amyloid-images-of-the-japanese-alzheimer-s-disease-neuroimaging-initiative-j-adni-multicenter-study
#15
Tomohiko Yamane, Kenji Ishii, Muneyuki Sakata, Yasuhiko Ikari, Tomoyuki Nishio, Kazunari Ishii, Takashi Kato, Kengo Ito, Michio Senda
PURPOSE: The aim of this study was to assess the inter-rater variability of the visual interpretation of (11)C-PiB PET images regarding the positivity/negativity of amyloid deposition that were obtained in a multicenter clinical research project, Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI). The results of visual interpretation were also compared with a semi-automatic quantitative analysis using mean cortical standardized uptake value ratio to the cerebellar cortex (mcSUVR)...
December 13, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27943341/pittsburgh-compound-b-pib-binds-amyloid-%C3%AE-protein-protofibrils
#16
Ghiam Yamin, David B Teplow
The neuropathology of Alzheimer's disease (AD) includes amyloid plaque formation by the amyloid β-protein (Aβ) and intracellular paired helical filament formation by tau protein. These neuropathogenetic features correlate with disease progression and have been revealed in brains of AD patients using positron emission tomography (PET). One of the most useful positron emission tomography imaging agents has been Pittsburgh Compound-B (PiB). However, since its introduction in 2002, substantial evidence has accumulated suggesting that Aβ oligomerization and protofibril formation, rather than fibril formation per se, may be the more important pathogenetic event in AD...
January 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27941122/first-pet-imaging-studies-with-63zn-zinc-citrate-in-healthy-human-participants-and-patients-with-alzheimer-disease
#17
Timothy R DeGrado, Bradley J Kemp, Mukesh K Pandey, Huailei Jiang, Tina M Gunderson, Logan R Linscheid, Allison R Woodwick, Daniel M McConnell, Joel G Fletcher, Geoffrey B Johnson, Ronald C Petersen, David S Knopman, Val J Lowe
Abnormalities in zinc homeostasis are indicated in many human diseases, including Alzheimer disease (AD). (63)Zn-zinc citrate was developed as a positron emission tomography (PET) imaging probe of zinc transport and used in a first-in-human study in 6 healthy elderly individuals and 6 patients with clinically confirmed AD. Dynamic PET imaging of the brain was performed for 30 minutes following intravenous administration of (63)Zn-zinc citrate (∼330 MBq). Subsequently, body PET images were acquired. Urine and venous blood were analyzed to give information on urinary excretion and pharmacokinetics...
2016: Molecular Imaging
https://www.readbyqxmd.com/read/27910823/optimized-mlaa-for-quantitative-non-tof-pet-mr-of-the-brain
#18
Didier Benoit, Claes N Ladefoged, Ahmadreza Rezaei, Sune H Keller, Flemming L Andersen, Liselotte Højgaard, Adam E Hansen, Søren Holm, Johan Nuyts
For quantitative tracer distribution in positron emission tomography, attenuation correction is essential. In a hybrid PET/CT system the CT images serve as a basis for generation of the attenuation map, but in PET/MR, the MR images do not have a similarly simple relationship with the attenuation map. Hence attenuation correction in PET/MR systems is more challenging. Typically either of two MR sequences are used: the Dixon or the ultra-short time echo (UTE) techniques. However these sequences have some well-known limitations...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27869301/cerebral-amyloid-deposition-is-associated-with-gait-parameters-in-the-mayo-clinic-study-of-aging
#19
Alexandra M V Wennberg, Rodolfo Savica, Clinton E Hagen, Rosebud O Roberts, David S Knopman, John H Hollman, Prashanthi Vemuri, Clifford R Jack, Ronald C Petersen, Michelle M Mielke
OBJECTIVES: To determine the cross-sectional association between cerebral amyloid-beta (Aβ) deposition and gait. DESIGN: Cross-sectional. SETTING: Population-based cohort study in Olmsted County, MN. PARTICIPANTS: Cognitively normal individuals (n = 611), aged 50 to 69 years, enrolled in the Mayo Clinic Study of Aging with concurrent PiB-PET imaging and gait assessment. Participants with a history of stroke, alcoholism, Parkinson's disease, subdural hematoma, traumatic brain injury, or normal pressure hydrocephalus were excluded...
November 21, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27867033/differences-in-a%C3%AE-brain-networks-in-alzheimer-s-disease-and-healthy-controls
#20
Huoqiang Duan, Jiehui Jiang, Jun Xu, Hucheng Zhou, Zhemin Huang, Zhihua Yu, Zhuangzhi Yan
The prevailing β-amyloid (Aβ)-cascade hypothesis is the most classical Alzheimer's disease (AD) pathogenesis. In this hypothesis, excessive Aβ plaque deposition in human brain is considered to be the cause of AD. Carbon 11-labeled Pittsburgh compound B Positron emission tomography (11C-PiB PET) is the latest technology to detect Aβ plaques in vivo. Thus, it is possible to investigate the difference of Aβ brain networks between AD patients and Health Controls (HC) by analyzing 11C-PiB PET images. In this study, a graph-theoretical method was employed to investigate the topological properties of Aβ networks in 18 Chinese AD patients and 16 HC subjects from Huashan Hospital, Shanghai...
January 15, 2017: Brain Research
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