keyword
MENU ▼
Read by QxMD icon Read
search

PIB

keyword
https://www.readbyqxmd.com/read/28507319/longitudinal-changes-of-tau-pet-imaging-in-relation-to-hypometabolism-in-prodromal-and-alzheimer-s-disease-dementia
#1
K Chiotis, L Saint-Aubert, E Rodriguez-Vieitez, A Leuzy, O Almkvist, I Savitcheva, M Jonasson, M Lubberink, A Wall, G Antoni, A Nordberg
The development of tau-specific positron emission tomography (PET) tracers allows imaging in vivo the regional load of tau pathology in Alzheimer's disease (AD) and other tauopathies. Eighteen patients with baseline investigations enroled in a 17-month follow-up study, including 16 with AD (10 had mild cognitive impairment and a positive amyloid PET scan, that is, prodromal AD, and six had AD dementia) and two with corticobasal syndrome. All patients underwent PET scans with [(18)F]THK5317 (tau deposition) and [(18)F]FDG (glucose metabolism) at baseline and follow-up, neuropsychological assessment at baseline and follow-up and a scan with [(11)C]PIB (amyloid-β deposition) at baseline only...
May 16, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28507298/protective-effects-of-apoe-e2-against-disease-progression-in-subcortical-vascular-mild-cognitive-impairment-patients-a-three-year-longitudinal-study
#2
Yeo Jin Kim, Sang Won Seo, Seong Beom Park, Jin Ju Yang, Jin San Lee, Juyoun Lee, Young Kyoung Jang, Sung Tae Kim, Kyung-Han Lee, Jong Min Lee, Jae-Hong Lee, Jae Seung Kim, Duk L Na, Hee Jin Kim
Although the association between apolipoprotein E (APOE) genotype and disease progression is well characterized in patients with Alzheimer's disease, such a relationship is unknown in patients with subcortical vascular cognitive impairment. We evaluated whether APOE genotype is associated with disease progression in subcortical vascular mild cognitive impairment (svMCI) patients. We prospectively recruited 72 svMCI patients (19 APOE4 carriers, 42 APOE3 homozygotes, and 11 APOE2 carriers). Patients were annually followed-up with brain MRI and neuropsychological tests for three years and underwent a second Pittsburgh compound B (PiB)-PET at a mean interval of 32...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28493513/metal-free-poly-cycloaddition-of-activated-azide-and-alkynes-toward-multifunctional-polytriazoles-aggregation-induced-emission-explosive-detection-fluorescent-patterning-and-light-refraction
#3
Yongwei Wu, Benzhao He, Changyun Quan, Chao Zheng, Haiqin Deng, Rongrong Hu, Zujin Zhao, Fei Huang, Anjun Qin, Ben Zhong Tang
The metal-free click polymerization (MFCP) of activated alkynes and azides or activated azide and alkynes have been developed into powerful techniques for the construction of polytriazoles without the obsession of metallic catalyst residues problem. However, the MFCP of activated azides and alkynes is rarely applied in preparation of functional polytriazoles. In this paper, soluble multifunctional polytriazoles (PIa and PIb) with high weight-average molecular weights (Mw up to 32 000) are prepared via the developed metal-free poly-cycloaddition of activated azide and alkynes in high yields (up to 90%)...
May 11, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28492352/the-physiological-incubation-biosimulator-pibs-an-improved-ex-vivo-experimental-setup-for-the-mechanical-stability-of-biological-sealants-in-surgical-procedures
#4
Philipp Höhn, Marie Buchholz, Britta Majchrzak, Waldemar Uhl, Chris Braumann, Ansgar M Chromik
BACKGROUND: Tissue-bound fibrin sealants are used in a wide array of surgical procedures. The microenvironmental interaction between sealant and application site is often poorly evaluated due to a lack of suitable experimental models. METHODS: A physiological incubation biosimulator (PIBS) was developed to test biological sealants in an ex vivo setup under physiological conditions comparable to the microenvironment at application site (temperature, humidity, pressure)...
June 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28482213/brain-predicted-age-in-down-syndrome-is-associated-with-beta-amyloid-deposition-and-cognitive-decline
#5
James H Cole, Tiina Annus, Liam R Wilson, Ridhaa Remtulla, Young T Hong, Tim D Fryer, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Robert Smith, David K Menon, Shahid H Zaman, Peter J Nestor, Anthony J Holland
Individuals with Down syndrome (DS) are more likely to experience earlier onset of multiple facets of physiological aging. This includes brain atrophy, beta amyloid deposition, cognitive decline, and Alzheimer's disease-factors indicative of brain aging. Here, we employed a machine learning approach, using structural neuroimaging data to predict age (i.e., brain-predicted age) in people with DS (N = 46) and typically developing controls (N = 30). Chronological age was then subtracted from brain-predicted age to generate a brain-predicted age difference (brain-PAD) score...
April 18, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28474977/pittsburgh-compound-b-pet-white-matter-imaging-and-cognitive-function-in-late-multiple-sclerosis
#6
Burcu Zeydan, Val J Lowe, Christopher G Schwarz, Scott A Przybelski, Nirubol Tosakulwong, Samantha M Zuk, Matthew L Senjem, Jeffrey L Gunter, Rosebud O Roberts, Michelle M Mielke, Eduardo E Benarroch, Moses Rodriguez, Mary M Machulda, Timothy G Lesnick, David S Knopman, Ronald C Petersen, Clifford R Jack, Kejal Kantarci, Orhun H Kantarci
BACKGROUND: There is growing interest in white matter (WM) imaging with positron emission tomography (PET). OBJECTIVES: We studied the association of cognitive function in late multiple sclerosis (MS) with cortical and WM Pittsburgh compound-B PET (PiB-PET) binding. METHODS: In the population-based Mayo Clinic Study of Aging, 24 of 4869 participants had MS (12 underwent PiB-PET). Controls were age and sex matched (5:1). We used automated or semi-automated processing for quantitative image analyses and conditional logistic regression for group differences...
May 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28468845/bdnf-val66met-predicts-cognitive-decline-in-the-wisconsin-registry-for-alzheimer-s-prevention
#7
Elizabeth A Boots, Stephanie A Schultz, Lindsay R Clark, Annie M Racine, Burcu F Darst, Rebecca L Koscik, Cynthia M Carlsson, Catherine L Gallagher, Kirk J Hogan, Barbara B Bendlin, Sanjay Asthana, Mark A Sager, Bruce P Hermann, Bradley T Christian, Dena B Dubal, Corinne D Engelman, Sterling C Johnson, Ozioma C Okonkwo
OBJECTIVE: To examine the influence of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on longitudinal cognitive trajectories in a large, cognitively healthy cohort enriched for Alzheimer disease (AD) risk and to understand whether β-amyloid (Aβ) burden plays a moderating role in this relationship. METHODS: One thousand twenty-three adults (baseline age 54.94 ± 6.41 years) enrolled in the Wisconsin Registry for Alzheimer's Prevention underwent BDNF genotyping and cognitive assessment at up to 5 time points (average follow-up 6...
May 3, 2017: Neurology
https://www.readbyqxmd.com/read/28445532/use-of-molecular-markers-in-identification-and-characterization-of-resistance-to-rice-blast-in-india
#8
Manoj Kumar Yadav, Aravindan S, Umakanta Ngangkham, H N Shubudhi, Manas Kumar Bag, Totan Adak, Sushmita Munda, Sanghamitra Samantaray, Mayabini Jena
Rice blast disease caused by Magnaporthe oryzae is one of the most destructive disease causing huge losses to rice yield in different parts of the world. Therefore, an attempt has been made to find out the resistance by screening and studying the genetic diversity of eighty released rice varieties by National Rice Research Institute, Cuttack (NRVs) using molecular markers linked to twelve major blast resistance (R) genes viz Pib, Piz, Piz-t, Pik, Pik-p, Pikm Pik-h, Pita/Pita-2, Pi2, Pi9, Pi1 and Pi5. Out of which, nineteen varieties (23...
2017: PloS One
https://www.readbyqxmd.com/read/28435853/preclinical-alzheimer-s-disease-and-longitudinal-driving-decline
#9
Catherine M Roe, Ganesh M Babulal, Denise M Head, Sarah H Stout, Elizabeth K Vernon, Nupur Ghoshal, Brad Garland, Peggy P Barco, Monique M Williams, Ann Johnson, Rebecca Fierberg, M Scot Fague, Chengjie Xiong, Elizabeth Mormino, Elizabeth A Grant, David M Holtzman, Tammie L S Benzinger, Anne M Fagan, Brian R Ott, David B Carr, John C Morris
INTRODUCTION: Links between preclinical AD and driving difficulty onset would support the use of driving performance as an outcome in primary and secondary prevention trials among older adults (OAs). We examined whether AD biomarkers predicted the onset of driving difficulties among OAs. METHODS: 104 OAs (65+ years) with normal cognition took part in biomarker measurements, a road test, clinical and psychometric batteries and self-reported their driving habits. RESULTS: Higher values of CSF tau/Aβ42 and ptau181/Aβ42 ratios, but not uptake on PIB amyloid imaging (p=...
January 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/28432784/contributions-of-imprecision-in-pet-mri-rigid-registration-to-imprecision-in-amyloid-pet-suvr-measurements
#10
Christopher G Schwarz, David T Jones, Jeffrey L Gunter, Val J Lowe, Prashanthi Vemuri, Matthew L Senjem, Ronald C Petersen, David S Knopman, Clifford R Jack
Quantitative measurement of β-amyloid from amyloid PET scans typically relies on localizing target and reference regions by image registration to MRI. In this work, we present a series of simulations where 50 small random perturbations of starting location and orientation were applied to each subject's PET scan, and rigid registration using spm_coreg was performed between each perturbed PET scan and its corresponding MRI. We then measured variation in the output PET-MRI registrations and how this variation affected the resulting SUVR measurements...
April 22, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28432674/partial-volume-correction-of-brain-pet-studies-using-iterative-deconvolution-in-combination-with-hypr-denoising
#11
Sandeep S V Golla, Mark Lubberink, Bart N M van Berckel, Adriaan A Lammertsma, Ronald Boellaard
BACKGROUND: Accurate quantification of PET studies depends on the spatial resolution of the PET data. The commonly limited PET resolution results in partial volume effects (PVE). Iterative deconvolution methods (IDM) have been proposed as a means to correct for PVE. IDM improves spatial resolution of PET studies without the need for structural information (e.g. MR scans). On the other hand, deconvolution also increases noise, which results in lower signal-to-noise ratios (SNR). The aim of this study was to implement IDM in combination with HighlY constrained back-PRojection (HYPR) denoising to mitigate poor SNR properties of conventional IDM...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28395177/regional-amyloid-burden-and-lacune-in-pure-subcortical-vascular-cognitive-impairment
#12
Yun Jeong Hong, Chan-Mi Kim, Ji Eun Kim, Jee Hoon Roh, Jae Seung Kim, Sang Won Seo, Duk L Na, Jae-Hong Lee
We investigated the amyloid and vascular burden in Pittsburgh compound B (PiB)-negative subcortical vascular mild cognitive impairment (svMCI) and PiB-negative subcortical ischemic vascular dementia (SIVD) to elucidate the potential roles of amyloid deposition and small vessel disease (SVD). Thirty-eight svMCI patients and 42 SIVD patients were enrolled. The regional PiB uptake values and SVD markers were obtained and compared between groups. Additionally, correlations among amyloid burden, SVD, and cognition were made...
March 16, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28385579/memory-self-awareness-in-the-preclinical-and-prodromal-stages-of-alzheimer-s-disease
#13
Patrizia Vannini, Rebecca Amariglio, Bernard Hanseeuw, Keith A Johnson, Donald G McLaren, Jasmeer Chhatwal, Alvaro Pascual-Leone, Dorene Rentz, Reisa A Sperling
While loss of insight of cognitive deficits, anosognosia, is a common symptom in Alzheimer's disease dementia, there is a lack of consensus regarding the presence of altered awareness of memory function in the preclinical and prodromal stages of the disease. Paradoxically, very early in the Alzheimer's disease process, individuals may experience heightened awareness of memory changes before any objective cognitive deficits can be detected, here referred to as hypernosognosia. In contrast, awareness of memory dysfunction shown by individuals with mild cognitive impairment (MCI) is very variable, ranging from marked concern to severe lack of insight...
May 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28385551/down-syndrome-age-dependence-of-pib-binding-in-postmortem-frontal-cortex-across-the-lifespan
#14
Harry LeVine, H Peter Spielmann, Sergey Matveev, Francesca Macchiavello Cauvi, M Paul Murphy, Tina L Beckett, Katie McCarty, Ira T Lott, Eric Doran, Frederick Schmitt, Elizabeth Head
Beta-amyloid (Aβ) deposition in brain accumulates as a function of age in people with Down syndrome (DS) with subsequent development into Alzheimer disease neuropathology, typically by 40 years of age. In vivo imaging using the Pittsburgh compound B (PiB) ligand has facilitated studies linking Aβ, cognition, and dementia in DS. However, there are no studies of PiB binding across the lifespan in DS. The current study describes in vitro (3)H-PiB binding in the frontal cortex of autopsy cases with DS compared to non-DS controls...
June 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28356201/the-risk-of-level-ib-nodal-involvement-in-oropharynx-cancer-guidance-for-submandibular-gland-sparing-irradiation
#15
Nicholas C J Lee, Jacqueline R Kelly, Henry S Park, Wendell G Yarbrough, Barbara A Burtness, Zain A Husain
PURPOSE: Xerostomia remains a common side effect of head and neck irradiation. Conflicting data exist regarding the likelihood of level IB involvement for patients with oropharyngeal squamous cell cancer (OPSCC), and data are limited on this risk in patients with human papillomavirus-positive disease. This study examined surgically treated OPSCC to determine the risk of pathologic level IB nodal involvement and to identify a cohort of patients in whom ipsilateral level IB radiation therapy may be safely omitted...
February 16, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28346588/association-between-childhood-onset-epilepsy-and-amyloid-burden-5-decades-later
#16
Juho Joutsa, Juha O Rinne, Bruce Hermann, Mira Karrasch, Anu Anttinen, Shlomo Shinnar, Matti Sillanpää
Importance: The effect of childhood epilepsy on later-life cognitive and brain health is an unclear and little-explored issue. Objective: To determine whether adults with a history of childhood-onset epilepsy exhibit increased brain amyloid accumulation, possibly predisposing to accelerated cognitive impairment or even frank cognitive disorders in later life. Design, Setting, and Participants: Forty-one adults from a population-based cohort of individuals with childhood-onset epilepsy in southwestern Finland, together with 46 matched population-based controls, underwent amyloid ligand carbon 11-labeled Pittsburgh Compound B (PiB) positron emission tomography after long-term prospective follow-up...
May 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28335021/mri-visible-perivascular-space-location-is-associated-with-alzheimer-s-disease-independently-of-amyloid-burden
#17
Gargi Banerjee, Hee Jin Kim, Zoe Fox, H Rolf Jäger, Duncan Wilson, Andreas Charidimou, Han Kyu Na, Duk L Na, Sang Won Seo, David J Werring
Perivascular spaces that are visible on magnetic resonance imaging (MRI) are a neuroimaging marker of cerebral small vessel disease. Their location may relate to the type of underlying small vessel pathology: those in the white matter centrum semi-ovale have been associated with cerebral amyloid angiopathy, while those in the basal ganglia have been associated with deep perforating artery arteriolosclerosis. As cerebral amyloid angiopathy is an almost invariable pathological finding in Alzheimer's disease, we hypothesized that MRI-visible perivascular spaces in the centrum semi-ovale would be associated with a clinical diagnosis of Alzheimer's disease, whereas those in the basal ganglia would be associated with subcortical vascular cognitive impairment...
April 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28330509/chemically-treated-plasma-a%C3%AE-is-a-potential-blood-based-biomarker-for-screening-cerebral-amyloid-deposition
#18
Jong-Chan Park, Sun-Ho Han, Hyun Jin Cho, Min Soo Byun, Dahyun Yi, Young Min Choe, Seokjo Kang, Eun Sun Jung, Su Jin Won, Eun Hye Kim, Yu Kyeong Kim, Dong Young Lee, Inhee Mook-Jung
BACKGROUND: Plasma β-amyloid (Aβ) is a potential candidate for an Alzheimer's disease (AD) biomarker because blood is an easily accessible bio-fluid, which can be collected routinely, and Aβ is one of the major hallmarks of AD pathogenesis in the brain. However, the association between plasma Aβ levels and AD diagnosis is still unclear due to the instability and inaccurate measurements of plasma Aβ levels in the blood of patients with AD. If a consistent value of plasma Aβ from the blood can be obtained, this might help determine whether plasma Aβ is a potential biomarker for AD diagnosis...
March 22, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28328855/head-to-head-comparison-of-11c-pib-and-18f-fc119s-for-a%C3%AE-imaging-in-healthy-subjects-mild-cognitive-impairment-patients-and-alzheimer-s-disease-patients
#19
COMPARATIVE STUDY
Byung Hyun Byun, Byung Il Kim, Su Yeon Park, In Ok Ko, Kyo Chul Lee, Kyeong Min Kim, Yu Kyeong Kim, Jun-Young Lee, Seon Hee Bu, Jung Hwa Kim, Dae Yoon Chi, Jeong Ho Ha, Sang Moo Lim
As a new beta amyloid (Aβ) positron emission tomography (PET) tracer, F-FC119S has shown higher cortical uptake in patients with Alzheimer's disease (AD) than that in healthy control subjects without adverse effects in a previous preliminary study. The aim of this study was to compare F-FC119S PET and C-PiB PET in healthy control (HC) subjects, mild cognitive impairment (MCI) patients, and AD patients.A total of 48 subjects, including 28 HC subjects, 10 MCI patients, and 10 AD patients, underwent static F-FC119S PET (30 minutes after intravenous [i...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28314821/phases-of-hyperconnectivity-and-hypoconnectivity-in-the-default-mode-and-salience-networks-track-with-amyloid-and-tau-in-clinically-normal-individuals
#20
Aaron P Schultz, Jasmeer P Chhatwal, Trey Hedden, Elizabeth C Mormino, Bernard J Hanseeuw, Jorge Sepulcre, Willem Huijbers, Molly LaPoint, Rachel F Buckley, Keith A Johnson, Reisa A Sperling
Alzheimer's disease (AD) is characterized by two hallmark molecular pathologies: amyloid aβ1-42 and Tau neurofibrillary tangles. To date, studies of functional connectivity MRI (fcMRI) in individuals with preclinical AD have relied on associations with in vivo measures of amyloid pathology. With the recent advent of in vivo Tau-PET tracers it is now possible to extend investigations on fcMRI in a sample of cognitively normal elderly humans to regional measures of Tau. We modeled fcMRI measures across four major cortical association networks [default-mode network (DMN), salience network (SAL), dorsal attention network, and frontoparietal control network] as a function of global cortical amyloid [Pittsburgh Compound B (PiB)-PET] and regional Tau (AV1451-PET) in entorhinal, inferior temporal (IT), and inferior parietal cortex...
April 19, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
keyword
keyword
43828
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"