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Muladili Yuemaier, Mayire Tuerhong, Abulizi Keremu, Nafeisha Kadeer, Ayiguzhali Aimaiti, Xilinguli Wushouer, Adilijiang Yiming, Xiamixinuer Yilike
This study aimed to establish and explore the biological basis of abnormal phlegmatic syndrome with premature ovarian failure (POF) model in rats based on the Uighur medicine (UM) in the first place and investigate the effects of unique herbal medicine, Balgham Munziq (BMq). Mature female Wistar rats were fed with spinach and coriander in cold and humid condition for approximately 20 weeks until abnormal phlegmatic syndrome (APS) model was established. When APS model was confirmed by Uighur medical experts, APS with POF disease rats were subdivided into APS with POF disease model group and APS with POF disease treated with BMq group; the rest of them were subdivided into APS model group and APS treated with BMq group...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Yuanzhi Zhu, Xifan Chen, Jing Liu, Junfeng Zhang, Danyun Xu, Wenchao Peng, Yang Li, Guoliang Zhang, Fengbao Zhang, Xiaobin Fan
Porous organic polymers (POFs) are promising precursors for developing high performance transition metal-nitrogen-carbon (M-N/C) catalysts towards ORR. But the rational design of POFs precursors remain a great challenge, because of the elusive structural association between the sacrificial POFs and the final M-N/C catalysts. Based on covalent triazine frameworks (CTFs), we developed a series of sulfur-doped Fe-N/C catalysts by selecting six different aromatic nitriles as building blocks. A new mixed solvent of molten FeCl3 and S was used for CTF polymerization, which benefit the formation of Fe-Nx site and make the subsequent pyrolysis process more convenient...
May 15, 2018: ChemSusChem
Lei Chen, Shilei Guo, Cui Wei, Honglan Li, Haiya Wang, Yan Xu
Stem cell transplantation has been considered a promising therapeutic approach for premature ovarian failure (POF). However, to date, no quantitative data analysis of stem cell therapy for POF has been performed. Therefore, the present study performed a meta-analysis to assess the efficacy of stem cell transplantation in improving ovarian function in animal models of POF. In addition, a case report of a patient with POF subjected to stem cell treatment was included to demonstrate that stem cell therapy also contributes to the recovery of ovarian function in patients...
May 2018: Experimental and Therapeutic Medicine
Jin Liu, Dai-Chao Wu, Li-Hua Qu, Hong-Qing Liao, Mei-Xiang Li
The mammalian target of rapamycin, mTOR, is a serine-threonine protein kinase downstream of the phosphatidylinositol 3-kinase (PI3K)-AKT axis. The pathway can regulate cell growth, proliferation, and survival by activating ribosomal kinases. Recent studies have implicated the mTOR signaling pathway in ovarian neoplasms, polycystic ovary syndrome (PCOS) and premature ovarian failure (POF). Preclinical investigations have demonstrated that the PI3K/AKT/mTOR pathway is frequently activated in the control of various ovarian functions...
May 12, 2018: Clinical Anatomy
Xiao-Yan Fu, Hao-Hao Chen, Ning Zhang, Ming-Xing Ding, Ying-Er Qiu, Xiao-Ming Pan, Yuan-Shu Fang, Yi-Ping Lin, Qun Zheng, Wen-Qian Wang
Premature ovarian failure (POF) results from a number of disorders. The POF model is primarily based on chemotherapeutic injury, and hence is not suitable for assessing the effects of chronic stress on ovarian function. Therefore, improved animal models are required to analyze the effects of chronic stress on ovarian reserve. The feasibility of the chronic unpredictable mild stress (CUMS) method for establishing a model of POF was examined. The depressive behavior exhibited by rats was evaluated with the open field and sucrose preference tests...
May 8, 2018: Molecular Medicine Reports
Fashui Hong, Ling Wang
Background: Exposure to titanium dioxide nanoparticles (TiO2 NPs) that are widely used in food, medicine, sunscreen products and cosmetics is reported to cause ovarian damage and lower fertility in animals. However, the potential effects of TiO2 NPs application on premature ovarian failure (POF) have rarely been evaluated to date. Methods: In this study, female mice were continuously exposed to TiO2 NPs at doses of 2.5, 5 or 10 mg/kg via gavage instillation for 30 days, and investigated the serum hormones and autoimmunity markers associated with POF...
2018: International Journal of Nanomedicine
Jiajia Niu, Xiaolei Zhao, Yuanyuan Jin, Guotao Yang, Zhonghao Li, Juanjuan Wang, Ruiqi Zhao, Zhongyue Li
A solid-phase microextraction (SPME) fiber coated with a two-dimensional porous organic framework (POF), JUC-Z2, was synthesized by a sol-gel process. The JUC-Z2-coated SPME fiber was combined with gas chromatography-mass spectrometry/mass spectrometry (GC-MS/MS), and a direct analysis method without any derivatization step was developed for the determination of two major harmful aromatic amines (1-naphthylamine, 1-NA; 2-naphthylamine, 2-NA) in the urine of amokers. The new method exhibited satisfactory linearity in the wide range of 0...
April 27, 2018: Journal of Chromatography. A
Qiu-Xia Liang, Zhen-Bo Wang, Fei Lin, Chun-Hui Zhang, Hong-Mei Sun, Liang Zhou, Qian Zhou, Heide Schatten, Filhol-Cochet Odile, Boldyreff Brigitte, Qing-Yuan Sun, Wei-Ping Qian
Premature ovarian failure (POF), a major cause of female infertility, is a complex disorder, but the molecular mechanisms underlying the disorder are only poorly understood. Here we report that protein kinase CK2 contributes to maintaining follicular survival through PI3K/AKT pathway and DNA damage response pathway. Targeted deletion of CK2β in mouse oocytes from the primordial follicle stage resulted in female infertility, which was attributed to POF incurring by massive follicle atresia. Downregulated PI3K/AKT signaling was found after CK2β deletion, indicated by reduced level of phosphorylated AKT (S473, T308, and S129) and altered AKT targets related to cell survival...
May 3, 2018: Cell Death & Disease
Yingzi Zhang, Yulong Hou, Yanjun Zhang, Yanjun Hu, Liang Zhang, Xiaolong Gao, Huixin Zhang, Wenyi Liu
A quasi-distributed liquid leakage (QDLL) sensor in local area is proposed and experimentally demonstrated, providing a real-time yet low-cost method than the existing local QDLL sensor. The sensor mainly consists of a flexible lamp belt (FLB) with light-emitting diodes (LEDs) and a polymer optical fiber (POF) processed with side-coupling structures. The side-coupling structures are illuminated by the LEDs one by one, forming a series of sensing probes. The lights are side-coupled into the POF through the side-coupling structure and pulse sequences are obtained from the power meters connected to the both ends of the POF...
April 16, 2018: Optics Express
Xin Lin, Xingting Liu, Yanfen Ma, Yuling Mi, Weidong Zeng, Jian Li, Caiqiao Zhang
After ovulation in mammals, rupture of mature follicles is reorganized into the corpus luteum that secrets progesterone (P4 ) to stimulate endometrial development. The situation in birds differs considerably. Beyond ovulation the ruptured avian follicle forms a postovulatory follicle (POF) that is not considered analogous to mammalian corpus luteum. The function and regression mechanisms of avian POFs remain poorly understood. Here we investigated the changes in apoptotic and autophagic activities that were involved during POF degradation...
April 29, 2018: Aging
Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Asli Cetin, Nese Basak
BACKGROUND: In recent years, cancer rates have been rising among reproductive-age women. Thus, chemotherapy exposure has become an important cause of premature ovarian failure (POF). There has been growing interest regarding the preservation and restoration of ovarian function before and after oncological treatment because of the reproductive risk of chemotherapeutics and improved long-term survival of cancer patients. In this study, we sought to analyze the effects of curcumin (CRC) and capsaicin (CPS) on cyclophosphamide-induced POF in a rat model...
April 26, 2018: Journal of Ovarian Research
Xiang Hu, Qiao Zhang, Feng Gao, Lu-Lu Chen
Premature ovarian failure (POF) is a heterogeneous condition affecting girls and women. We detected a previously healthy 18-year-old adolescent girl, presented with amenorrhea over six months, as well as circulating levels of estradiol lower decreased and follicle-stimulating hormone (FSH) increased. She was 138 cm tall. Results of laboratory tests and/or ultrasound investigations showed 46, X, i(X)(q10) karyotype and Hashimoto's disease. This case suggests that pubertal onset and progression, as well as karyotype analysis, should be evaluated in girls with Hashimoto's disease and short stature...
April 22, 2018: Gynecological Endocrinology
Hanna Sternby, Federico Bolado, Héctor J Canaval-Zuleta, Carlos Marra-López, Ana I Hernando-Alonso, Adolfo Del-Val-Antoñana, Guillermo García-Rayado, Robin Rivera-Irigoin, Francisco J Grau-García, Lluís Oms, Judith Millastre-Bocos, Isabel Pascual-Moreno, David Martínez-Ares, Juan A Rodríguez-Oballe, Antonio López-Serrano, María L Ruiz-Rebollo, Alejandro Viejo-Almanzor, Belén González-de-la-Higuera, Aitor Orive-Calzada, Ignacio Gómez-Anta, José Pamies-Guilabert, Fátima Fernández-Gutiérrez-Del-Álamo, Isabel Iranzo-González-Cruz, Mónica E Pérez-Muñante, María D Esteba, Ana Pardillos-Tomé, Pedro Zapater, Enrique de-Madaria
OBJECTIVE: The aim of this study was to compare and validate the different classifications of severity in acute pancreatitis (AP) and to investigate which characteristics of the disease are associated with worse outcomes. SUMMARY OF BACKGROUND DATA: AP is a heterogeneous disease, ranging from uneventful cases to patients with considerable morbidity and high mortality rates. Severity classifications based on legitimate determinants of severity are important to correctly describe the course of disease...
April 18, 2018: Annals of Surgery
Bo-Quan Li, Shu-Yuan Zhang, Long Kong, Hong-Jie Peng, Qiang Zhang
Organic frameworks represent an emerging family of advanced materials that can be precisely controlled at the atomic level. However, morphology control of organic frameworks remains perplexing and difficult, strongly limiting the advantages of organic frameworks in multiple practical applications. Herein, porphyrin organic framework hollow spheres (POF-HSs) are fabricated by a template method as a proof of concept of organic frameworks with precisely controlled morphology. POF-HS exhibits explicit chemical structures of 2D POF and an expected hollow structure...
April 16, 2018: Advanced Materials
Arnaldo Leal-Junior, Anselmo Frizera, Maria José Pontes, Paulo Antunes, Nélia Alberto, Maria Fátima Domingues, Heeyoung Lee, Ryo Ishikawa, Yosuke Mizuno, Kentaro Nakamura, Paulo André, Carlos Marques
This Letter presents, for the first time, to the best of our knowledge, the dynamic mechanical analysis of a polymer optical fiber (POF) that was previously damaged by the catastrophic fuse effect. The variation of the fiber Young's modulus was evaluated with respect to the increase of temperature, humidity, and frequency of strain cycles. The obtained data for the fused POF are compared with the ones for the same POF without the fuse effect. The results show the feasibility of the fused POF for sensor applications, such as strain and acceleration measurement, since it presents temperature sensitivity almost two times lower in temperatures between 26°C and 90°C and Young's modulus 2...
April 15, 2018: Optics Letters
Jun Li, Qingtong Yu, Haisen Huang, Wenwen Deng, Xia Cao, Michael Adu-Frimpong, Jiangnan Yu, Ximing Xu
BACKGROUND: Previous studies have reported that transplantation of mesenchymal stem cells (MSCs) from many human tissues could ameliorate ovarian dysfunction. However, no study has revealed the therapeutic efficiency of MSCs derived from the chorionic plate (CP-MSCs) for premature ovarian failure (POF). METHODS: We investigated the restorative effects of CP-MSCs on cyclophosphamide (CTX)-induced POF. The POF mouse models were established via intraperitoneal injection of 50 mg/kg CTX into female mice for 15 consecutive days...
April 3, 2018: Stem Cell Research & Therapy
JoAnne S Richards, Mario Ascoli
The central role of luteinizing hormone (LH) and its receptor (LHCGR) in triggering ovulation has been recognized for decades. Because the LHCGR is present in the mural (outermost) granulosa cell layer of preovulatory follicles (POFs), the LH-initiated signal has to be transmitted to another somatic cell type (cumulus granulosa cells) and the oocyte to release a fertilizable oocyte. Recent studies have shown that activation of the LHCGR initiates vectorial transfer of information among the two somatic cell types and the oocyte and the molecules and signaling pathways involved are now better understood...
March 27, 2018: Trends in Endocrinology and Metabolism: TEM
Golshan Sheikhansari, Leili Aghebati-Maleki, Mohammad Nouri, Farhad Jadidi-Niaragh, Mehdi Yousefi
One of the common disorders found in women is premature ovarian failure (POF). Recently some studies have explained premature ovarian insufficiency (POI). The causes of it are unknown although various types of study have been done. The most common causes such as genetic and autoimmune conditions can have a role in POF and can lead to infertility. Some characterization of POF are hypo-oestrogenism (estrogen deficiency), increased gonadotropin level and most importantly amenorrhea. The main purpose of this review is to describe the cause and treatment of POF, especially stem cell therapy proposed in previous studies...
June 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Arnaldo Leal-Junior, Anselmo Frizera-Neto, Carlos Marques, Maria José Pontes
This paper presents a system capable of measuring temperature and relative humidity with polymer optical fiber (POF) sensors. The sensors are based on variations of the Young's and shear moduli of the POF with variations in temperature and relative humidity. The system comprises two POFs, each with a predefined torsion stress that resulted in a variation in the fiber refractive index due to the stress-optic effect. Because there is a correlation between stress and material properties, the variation in temperature and humidity causes a variation in the fiber's stress, which leads to variations in the fiber refractive index...
March 20, 2018: Sensors
Lijun Ding, Guijun Yan, Bin Wang, Lu Xu, Yan Gu, Tong Ru, Xiaoying Cui, Lei Lei, Jingyu Liu, Xiaoqiang Sheng, Bin Wang, Chunxue Zhang, Yanjun Yang, Ruiwei Jiang, Jianjun Zhou, Na Kong, Feifei Lu, Huaijun Zhou, Yannan Zhao, Bing Chen, Yali Hu, Jianwu Dai, Haixiang Sun
Premature ovarian failure (POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study, umbilical cord mesenchymal stem cells on a collagen scaffold (collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles...
March 13, 2018: Science China. Life Sciences
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