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https://www.readbyqxmd.com/read/28936362/albumin-protein-cleavage-affects-the-wear-and-friction-of-ultra-high-molecular-weight-polyethylene
#1
Yasha Dwivedi, Michel P Laurent, Shravan Sarvepalli, Thomas M Schmid, Markus A Wimmer
It is well established that the total protein concentration and albumin-to-globulin ratio influence the wear of ultra-high molecular polyethylene (UHMWPE, "polyethylene") in joint prostheses. A factor on wear not yet studied, but of possible clinical relevance, is protein cleavage. Such cleavage is expected in the presence of an inflammatory response and as a result of wear processes at the articular interface. The aim of this study was to compare the tribological behavior of polyethylene articulated against an orthopedic wrought CoCrMo alloy for three lubricants: cleaved albumin, uncleaved albumin, and newborn calf serum (control)...
September 2017: Lubricants
https://www.readbyqxmd.com/read/28924383/functional-analysis-of-a-novel-foxl2-indel-mutation-in-chinese-families-with-blepharophimosis-ptosis-epicanthus-inversus-syndrome-type-i
#2
Peiwei Chai, Fang Li, Jiayan Fan, Ruobin Jia, He Zhang, Xianqun Fan
Background: Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is an autosomal dominant disease with a low incidence rate. Indel mutations in the forkhead box L2 (FOXL2) gene cause two types of BPES that are distinguished by the presence (type I) or absence (type II) of premature ovarian failure (POF). The purpose of this study was to identify a possible deletion in FOXL2 in Chinese families with BPES and to clarify its relationship with POF. Methods: An autosomal dominant Chinese BPES family with four generations was enrolled in this study...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28851265/post-operative-fever-in-orthopaedic-surgery-how-effective-is-the-fever-workup
#3
Blair Ashley, David A Spiegel, Patrick Cahill, Divya Talwar, Keith D Baldwin
BACKGROUND: Defining the appropriate threshold at which to initiate a fever workup is imperative to promote patient safety, appropriate resource utilization, and antibiotic stewardship. Our group performed a systematic review of the available literature on perioperative fever (POF) workups in orthopaedic patients to evaluate the frequency, timing and utility of blood cultures (BC) and other investigations in the POF workup, to determine the clinical relevance of any infections and to evaluate their cost effectiveness...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28841144/radiation-induced-attenuation-of-perfluorinated-polymer-optical-fibers-for-radiation-monitoring
#4
Pavol Stajanca, Katerina Krebber
Due to some of their unique properties, optical fiber dosimeters are attractive and extensively researched devices in several radiation-related areas. This work evaluates the performance and potential of commercial perfluorinated polymer optical fibers (PF-POFs) for radiation monitoring applications. Gamma radiation-induced attenuation (RIA) of two commercial PF-POFs is evaluated in the VIS spectral region. Influence of a dose rate and temperature on RIA measurement is investigated, along with defect stability and measurement repeatability...
August 25, 2017: Sensors
https://www.readbyqxmd.com/read/28829326/an-enhanced-decomposition-based-evolutionary-algorithm-with-adaptive-reference-vectors
#5
Md Asafuddoula, Hemant Kumar Singh, Tapabrata Ray
Multiobjective optimization problems with more than three objectives are commonly referred to as many-objective optimization problems (MaOPs). Development of algorithms to solve MaOPs has garnered significant research attention in recent years. ``Decomposition'' is a commonly adopted approach toward this aim, wherein the problem is divided into a set of simpler subproblems guided by a set of reference vectors. The reference vectors are often predefined and distributed uniformly in the objective space. Use of such uniform distribution of reference vectors has shown commendable performance on problems with ''regular'' Pareto optimal front (POF), i...
August 18, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28814333/rapamycin-prevents-cyclophosphamide-induced-over-activation-of-primordial-follicle-pool-through-pi3k-akt-mtor-signaling-pathway-in-vivo
#6
Linyan Zhou, Yanqiu Xie, Song Li, Yihua Liang, Qi Qiu, Haiyan Lin, Qingxue Zhang
BACKGROUND: Primordial follicular depletion has thought to be a common adverse effect of chemotherapy especially for female of reproductive age. The study aimed to evaluate the protective effect of rapamycin on the primordial follicles and its potential mechanism for patients receiving chemotherapy. METHODS: 8-week old BALB/c female mice were randomly assigned into four groups (control; rapamycin; cyclophosphamide; and rapamycin combined with cyclophosphamide). Hematoxylin staining, immunohistochemical, TUNEL, western blotting and ELISA were employed to assess inter-group differences using Student's t-test and Mann-Whitney test...
August 16, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28808236/decreased-high-density-lipoprotein-cholesterol-is-an-independent-predictor-for-persistent-organ-failure-pancreatic-necrosis-and-mortality-in-acute-pancreatitis
#7
Yushun Zhang, Feng Guo, Shoukang Li, Feiyang Wang, Zibo Meng, Jingyuan Zhao, Zhiqiang Liu, Bo Wang, Ping Fan, Chunyou Wang, Heshui Wu
High density lipoprotein cholesterol (HDL-C) has been reported as a significant indicator of systemic inflammation. The association underlying HDL-C and persistent organ failure (POF), pancreatic necrosis (PNec) and mortality in acute pancreatitis (AP) has not been evaluated. From 2007 to 2016, consecutive AP patients with admission lipid profiles assessment were included in this study. The association of HDL-C value and other lipids with outcomes was explored with Cox proportional regression models, which were adjusted for confounding factors...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807003/overexpression-of-mir-21-in-stem-cells-improves-ovarian-structure-and-function-in-rats-with-chemotherapy-induced-ovarian-damage-by-targeting-pdcd4-and-pten-to-inhibit-granulosa-cell-apoptosis
#8
Xiafei Fu, Yuanli He, Xuefeng Wang, Dongxian Peng, Xiaoying Chen, Xinran Li, Qing Wang
BACKGROUND: Chemotherapy-induced premature ovarian failure (POF) is a severe complication affecting tumor patients at a childbearing age. Mesenchymal stem cells (MSCs) can partially restore the ovarian structure and function damaged by chemotherapy. miR-21 is a microRNA that can regulate cell apoptosis. This study discusses the repair effect and mechanism of MSCs overexpressing miR-21 on chemotherapy-induced POF. METHODS: Rat MSCs and granulosa cells (GCs) were isolated in vitro...
August 14, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28770380/sex-steroids-modulate-morphological-and-functional-features-of-the-bovine-oviduct
#9
Angela Maria Gonella-Diaza, Fernando Silveira Mesquita, Kauê Ribeiro da Silva, Júlio Cesar de Carvalho Balieiro, Nilton Pedro Dos Santos, Guilherme Pugliesi, Ricardo de Francisco Strefezzi, Mario Binelli
In cattle, the oviduct plays a major role in the reproductive process; however, molecular control of oviduct receptivity to the embryo is poorly understood. A model for receptivity based on size of the pre-ovulatory follicle (POF) was used to compare oviductal morphology, cellular proliferation, and candidate transcript abundance. Growth of the POF of Nelore (Bos indicus) cows was manipulated to produce two groups: a large POF-large corpus luteum (CL) group (LF-LCL; greater receptivity) and a small POF-small CL group (SF-SCL)...
August 2, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28768058/prenatal-influence-of-congenital-heart-defects-on-trajectories-of-cortical-folding-of-the-fetal-brain-using-three-dimensional-ultrasound
#10
Irene V Koning, Anne W van Graafeiland, Irene A L Groenenberg, Sofie C Husen, Attie T J I Go, Jeroen Dudink, Sten P Willemsen, Jerome M J Cornette, Régine P M Steegers-Theunissen
OBJECTIVE: To investigate the prenatal influence of congenital heart defects (CHD) on trajectories of fetal cortical folding using three-dimensional ultrasound (3D-US). METHOD: We included 20 CHD fetuses and 193 controls for studying the fetal brain at 22, 26 and 32 weeks gestational age (GA). The Sylvian, insula and parieto-occipital fissure (POF) depths were measured using 3D-US and reliability was evaluated. Doppler indices of the umbilical artery and middle cerebral artery were measured to calculate the cerebro-placental ratio (CPR)...
August 2, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28752977/-correlation-between-dietary-nutrition-and-premature-ovarian-failure
#11
Hui Chen, Ran Cheng, Liang-Zhi Xu
OBJECTIVE: To explore the relationship between dietary nutrition and premature ovarian failure (POF). METHODS: A case control study was undertaken in 294 patients recruited from the reproductive endocrine clinic of our hospital over the period from November 2015 to January 2017. The POF group included women with premature ovarian failure , and women with normal menstruation were included as control group. The dietary and nutritional status of these patients were analyzed and compared...
July 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28721130/premature-ovarian-failure
#12
REVIEW
Katarzyna Jankowska
Premature ovarian failure (POF) is the term usually used to describe women aged younger than 40 years, who present with amenorrhoea, hypergonadotropic hypogonadism, and infertility. POF is a devastating diagnosis for reproductive-aged women. The clinical presentation is diverse, and several different disorders can lead to premature ovarian failure. POF has serious health consequences, including psychological distress, infertility, osteoporosis, autoimmune disorders, ischaemic heart disease, and increased risk of mortality...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28708503/effect-of-dietary-supplementation-of-omega-3-polyunsaturated-fatty-acid-pufa-rich-fish-oil-on-reproductive-performance-of-the-goat-capra-hircus
#13
Ajit Singh Mahla, Ravjibhai K Chaudhari, Atul Kumar Verma, Amit Kumar Singh, Sanjay Kumar Singh, Gyanendra Singh, Mihir Sarkar, Narayan Dutta, Harendra Kumar, Narayanan Krishnaswamy
Dietary supplementation of n-3 PUFA decreases the luteolytic PGF2α and improves the pregnancy rate in the dairy cow. However, its effect in the goat is not known. Accordingly, we studied the effect of supplementation of n-3 PUFA rich Fish oil (FO) on different reproductive events in the goat. Cycling goats (n = 30) were divided into two equal groups and fed an isocaloric and isonitrogenous diet supplemented with either FO (TRT; n = 15) or palm oil (PO) (CON; n = 15) @ 0.6 mL/kg body weight for 72 days during the breeding season...
May 26, 2017: Theriogenology
https://www.readbyqxmd.com/read/28691758/cooperative-activation-of-cobalt-salen-complexes-for-epoxide-hydration-promoted-on-flexible-porous-organic-frameworks
#14
Mingmei Zhong, He Li, Jian Chen, Lin Tao, Can Li, Qihua Yang
Developing solid catalysts with multiple active sites working cooperatively is desirable for efficient chemical transformations. However, most solid catalysts are rigid and impede the cooperation between their spatially isolated active sites. Two flexible porous organic frameworks (POFs) with integrated Co(salen) as active sites have been successfully synthesized for mimicking the cooperative modes of enzymes. The POFs exhibit second-order rate dependence on Co(salen) concentration in the network and afford much higher TOF (3300 versus 2670 h(-1) ) than the homogeneous counterpart in the hydration of propylene epoxide...
July 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28678972/the-role-of-osterix-protein-in-the-pathogenesis-of-peripheral-ossifying-fibroma
#15
Vivian Narana Ribeiro El Achkar, Raphaella da Silveira Medeiros, Fernanda Gargano Longue, Ana Lia Anbinder, Estela Kaminagakura
Peripheral ossifying fibroma (POF) is a reactive lesion of oral tissues, associated with local factors such as trauma or presence of dental biofilm. POF treatment consists of curettage of the lesion combined with root scaling of adjacent teeth and/or removal of other sources of irritants. This study aimed to analyze the clinical and pathological features of POF and to investigate the immunoexpression of Osterix and STRO-1 proteins. Data such as age, gender, and size were obtained from 30 cases of POF. Microscopic features were assessed by conventional light microscopy using hematoxylin-eosin staining and immunohistochemical markers, and by polarized light microscopy using Picrosirius red staining...
July 3, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28677787/cloning-of-the-promoter-region-of-a-human-gene-foxl2-and-its-regulation-by-stat3
#16
Yangyang Han, Tianxiao Wang, Shudong Sun, Zhaohui Zhai, Shengjian Tang
Forkhead box L2 (FOXL2) is a transcription factor, which is involved in blepharophimosis, ptosis, and epicanthus in versus syndrome (BPES), premature ovarian failure (POF), as well as almost all stages of ovarian development and function. FOXL2 has various target genes, which are implicated in numerous processes, including sex determination, cell cycle regulation and apoptosis and stress response regulation in mammals. However, studies regarding the upstream regulation of FOXL2 are limited. In the present study, the promoter of FOXL2 was successfully cloned and registered in Gen Bank, and a dual luciferase reporter (DLR) analysis demonstrated that the luciferase activity was significantly induced by the promoter of FOXL2...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28672796/slab-waveguide-and-optical-fibers-for-novel-plasmonic-sensor-configurations
#17
Nunzio Cennamo, Francesco Mattiello, Luigi Zeni
The use of plasmonic sensor devices often requires replaceable parts and disposable chips for easy, fast and on-site detection analysis. In light of these requests, we propose a novel low-cost surface plasmon resonance sensor platform for possible selective detection of analytes in aqueous solutions. It is based on a Polymethyl methacrylate (PMMA) slab waveguide with a thin gold film on the top surface inserted in a special holder, designed to produce the plasmonic resonance at the gold-dielectric interface...
June 24, 2017: Sensors
https://www.readbyqxmd.com/read/28669943/-a-prenatal-ultrasound-study-of-cerebral-sulci-and-gyrus-development-in-fetuses-with-tetralogy-of-fallot
#18
Jia-Min He, Sheng-Li Li, Xi Chen, Hua-Xuan Wen, Ying Yuan, Dan-Dan Luo
OBJECTIVE: To evaluate the development of the cerebral sulci and gyrus and cerebral blood flow in fetuses with tetralogy of Fallot (ToF) in the second and third trimesters using ultrasound imaging. METHODS: Forty fetuses (23-33(+6) weeks) with ToF diagnosed using ultrasound imaging between December, 2015 and September, 2016 were analyzed in this study. The development of the cerebral sulci and gyrus was evaluated by measuring the parietal-occipital fissure (POF) depth, POF angle, sylvian fissure (SF) depth, SF width, uncovered insular width, calcarine fissure (CF) depth, hemisphere depth on the views of POF, SF and CF, uncovered insular ratio, biparietal diameter (BPD), and head circumference (HC)...
June 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28655321/stratified-analysis-and-clinical-significance-of-elevated-serum-triglyceride-levels-in-early-acute-pancreatitis-a-retrospective-study
#19
Jianhua Wan, Wenhua He, Yin Zhu, Yong Zhu, Hao Zeng, Pi Liu, Liang Xia, Nonghua Lu
BACKGROUND: Hypertriglyceridemia is one of the three most common causes of AP, which is associated with the AP prognosis that has not been clearly defined. METHODS: In this retrospective study, 1539 AP patients, who had serum triglyceride (TG) levels measured within the first 72 h, were assessed. The study groups consisted of patients with normal, mild, moderate, and severe/very severe HTG levels based on the Endocrine Society Clinical Practice Guidelines. We collected baseline demographic information, laboratory values, complications, and clinical outcome data in different HTG severity groups to analyze the clinical significance of elevated TG levels in AP...
June 27, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28630707/evidence-of-endometrial-amino-acid-metabolism-and-transport-modulation-by-peri-ovulatory-endocrine-profiles-driving-uterine-receptivity
#20
Moana Rodrigues França, Maressa Izabel Santos da Silva, Guilherme Pugliesi, Veerle Van Hoeck, Mario Binelli
BACKGROUND: In beef cattle, changes in the periovulatory endocrine milieu are associated with fertility and conceptus growth. A large preovulatory follicle (POF) and the resulting elevated concentrations of progesterone (P4) during diestrus positively affect pregnancy rates. Amino acids (AA) are important components of maternally derived secretions that are crucial for embryonic survival before implantation. The hypothesis is that the size of the POF and the concentration of P4 in early diestrus modulate the endometrial abundance of SLC transcripts related to AA transport and metabolism and subsequently impact luminal concentrations of AA...
2017: Journal of Animal Science and Biotechnology
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