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https://www.readbyqxmd.com/read/27930667/protein-phosphatase-6-protects-prophase-i-arrested-oocytes-by-safeguarding-genomic-integrity
#1
Meng-Wen Hu, Tie-Gang Meng, Zong-Zhe Jiang, Ming-Zhe Dong, Heide Schatten, Xingzhi Xu, Zhen-Bo Wang, Qing-Yuan Sun
Mammalian oocytes are arrested at prophase of the first meiotic division in the primordial follicle pool for months, even years, after birth depending on species, and only a limited number of oocytes resume meiosis, complete maturation, and ovulate with each reproductive cycle. We recently reported that protein phosphatase 6 (PP6), a member of the PP2A-like subfamily, which accounts for cellular serine/threonine phosphatase activity, functions in completing the second meiosis. Here, we generated mutant mice with a specific deletion of Ppp6c in oocytes from the primordial follicle stage by crossing Ppp6cF/F mice with Gdf9-Cre mice and found that Ppp6cF/F; GCre+ mice are infertile...
December 8, 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27891401/premature-ovarian-failure-an-association-with-autoimmune-diseases
#2
Ayesha, Vandana Jha, Deepti Goswami
INTRODUCTION: Premature Ovarian Failure (POF) is the cessation of ovarian function before the age of 40 years. POF is reported to be associated with autoimmune diseases in 20-30% of cases. AIM: Patients presenting with idiopathic POF were screened for the presence of autoimmune disorders. MATERIALS AND METHODS: Twenty patients with idiopathic POF were included in the study. Baseline investigation in all subjects included fasting serum FSH, LH, E2, progesterone, free T3, free T4, Thyroid-Stimulating Hormone (TSH) and Anti-Thyroperoxidase (anti-TPO) antibodies, testosterone and Dehydroepiandrosterone (DHEAS) levels...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27876427/fmr1-premutation-not-only-important-in-premature-ovarian-failure-but-also-in-diminished-ovarian-reserve
#3
Ali Eslami, Kamelia Farahmand, Mehdi Totonchi, Tahereh Madani, Ummulbanin Asadpour, Shabnam Zari Moradi, Hamid Gourabi, Anahita Mohseni-Meybodi
It is recognized that FMR1 premutation expansions are associated with premature ovarian failure (POF), but their role in diminished ovarian reserve (DOR) is not clearly established. Moreover, the impact of smaller repeats at the boundary of premutation and normal is less clear. Therefore, we have compared the frequency of these intermediate (45-54 repeats) and premutation (>55) sized FMR1 CGG repeats among a patients group including 188 DOR and 173 POF women and 200 controls. FSH and LH concentrations were also compared between intermediate and premutation ranges in patients...
November 23, 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27802832/reproductive-issues-in-patients-undergoing-hematopoietic-stem-cell-transplantation-an-update
#4
REVIEW
Maurizio Guida, Maria Antonietta Castaldi, Rosa Rosamilio, Valentina Giudice, Francesco Orio, Carmine Selleri
In 1963 George Mathé announced to the world that he had cured a patient of leukaemia by means of a bone-marrow transplant. Since than much progress has been made and nowadays Hematopoietic Stem Cell Transplantation (HSCT) is considered the most effective treatment of numerous severe haematological diseases. Gynaecological complications in HSCT women represent a serious concern for these patients, but often underestimated by clinicians in the view of Overall Survival. The main gynaecological complications of HSCT are represented by: premature ovarian failure (POF), thrombocytopenia-associated menorrhagia, genital symptoms or sexual problems in course of chronic GVHD (cGVHD), osteoporosis, secondary solid tumours due to immunosuppressive drugs to treat cGVHD and severity of cGVHD, and fertility and pregnancy issues...
November 1, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27795650/peripheral-ossifying-fibroma-a-rare-case-affecting-maxillary-region
#5
Sahana Ashok, Anish Ashok Gupta, K P Ashok, Shubhangi Ashok Mhaske
Focal gingival enlargements are a diverse group of lesions with almost similar clinical presentation but varied etiology and histopathology. The actual cause of peripheral ossifying fibroma (POF) has been debated over many years. POFs are usually seen in childhood and younger ages. There is a slight female predilection. It is usually localized, rarely generalized. Usually, the treatment option is only surgical excision with minimal chances of recurrence. Here, we report a case of POF of the right maxillary posterior region with a review of literature...
September 2016: Indian Journal of Dentistry
https://www.readbyqxmd.com/read/27757285/the-clinical-functional-and-biomechanical-presentation-of-patients-with-symptomatic-hip-abductor-tendon-tears
#6
Jay R Ebert, Theertha Retheesh, Rinky Mutreja, Gregory C Janes
BACKGROUND: Hip abductor tendon (HAT) tearing is commonly implicated in greater trochanteric pain syndrome (GTPS), though limited information exists on the disability associated with this condition and specific presentation of these patients. PURPOSE: To describe the clinical, functional and biomechanical presentation of patients with symptomatic HAT tears. Secondary purposes were to investigate the association between these clinical and functional measures, and to compare the pain and disability reported by HAT tear patients to those with end-stage hip osteoarthritis (OA)...
October 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27733305/quantitative-analysis-of-the-trendelenburg-test-and-invention-of-a-modified-method
#7
Kenji Fujita, Tamon Kabata, Yoshitomo Kajino, Shintaro Iwai, Kazunari Kuroda, Kazuhiro Hasegawa, Katsuo Fujiwara, Hiroyuki Tsuchiya
BACKGROUND: While the Trendelenburg test has been used for 120 years to detect hip abductor muscle weakness, the methodology has not been standardised. PURPOSES: This study undertook to quantitatively analyze the relation between abductor muscle activity and pelvic tilt angle in the Trendelenburg one-leg stance, examine the pitfalls associated with performing the T-test, and develop a modified method that will produce reliable results. METHODS: A convenience sample of 15 healthy males was asked to assume a one-leg stance in ten different postures, five with mild flexion on the unsupported side, and five with severe flexion...
October 9, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27729272/cyclophosphamide-promotes-the-proliferation-inhibition-of-mouse-ovarian-granulosa-cells-and-premature-ovarian-failure-by-activating-the-lncrna-meg3-p53-p66shc-pathway
#8
Ying Xiong, Te Liu, Suwei Wang, Huiying Chi, Chuan Chen, Jin Zheng
The dysfunction of ovarian granulosa cells (OGCs) directly affects the premature ovarian failure (POF). In vivo experiments showed that cyclophosphamide significantly induced mouse ovarian atrophy and proliferation inhibition of OGCs. The expressions of p53, p66Shc and p16 were significantly higher in OGCs of the cyclophosphamide treatment group. MTT assay showed that cyclophosphamide effectively inhibited the proliferation of OGCs in vitro. SA-β-Gal staining showed that the OGCs in the cyclophosphamide treatment group had many senescent cells...
October 8, 2016: Gene
https://www.readbyqxmd.com/read/27688100/patterns-of-failure-after-reirradiation-with-intensity-modulated-radiation-therapy-and-the-competing-risk-of-out-of-field-recurrences
#9
Danielle N Margalit, Bhupendra Rawal, Paul J Catalano, Robert I Haddad, Laura A Goguen, Donald J Annino, Sewanti A Limaye, Jochen H Lorch, Annie W Lavigne, Jonathan D Schoenfeld, David J Sher, Roy B Tishler
PURPOSE: To describe patterns of failure (POF) after reirradiation (reRT) with intensity modulated radiation therapy (IMRT) for recurrent/second primary squamous cell carcinoma of the head and neck. METHODS: From 08/2004-02/2013, 75 consecutive patients received reRT with IMRT. Gross tumor was generally treated with a 5mm planning target volume (PTV) margin. For postoperative cases, a 5mm PTV was added to the clinical target volume which included the postoperative bed...
October 2016: Oral Oncology
https://www.readbyqxmd.com/read/27686934/early-prediction-of-persistent-organ-failure-by-serum-angiopoietin-2-in-patients-with-acute-pancreatitis
#10
Yu-Ping Zhang, Chang Liu, Lei Ye, Na Yu, Yuan-Ning Ye, Wen-Rong Sun, Lin Wu, Fang-Yu Wang
BACKGROUND: Biomarkers for the early prediction of the severity of acute pancreatitis (AP) are urgently needed for clinical management of the disease. Angiopoietin-2 (Ang-2), one of the autocrine peptides that reduce endothelial permeability, has been found to be associated with various diseases, including inflammatory disorders. AIMS: This study aimed to determine whether serum Ang-2 could serve as a noninvasive biomarker for the early prediction of persistent organ failure (POF) in acute pancreatitis...
September 29, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27681656/reduced-fetal-brain-fissures-depth-in-fetuses-with-congenital-heart-diseases
#11
Qinghai Peng, Qichang Zhou, Ming Zang, Jiawei Zhou, Ran Xu, Tao Wang, Shi Zeng
OBJECTIVE: To screen and detect cortex gyration in fetuses with congenital heart disease (CHD) using Ultrasonography (US) during routine obstetric scans. METHODS: The depth of the Sylvian fissure (SF), parieto-occipital fissure (POF), and calcarine (CF) fissure were prospectively serially measured and compared in 45 fetuses with CHD and 45 normal fetuses. Cardiac hemodynamic parameters, including aortic valve diameter (AV), pulmonary valve diameter (PV), velocity time integral of the aortic valve (VTIav), and velocity time integral of the pulmonary valve (VTIpv), were recorded...
November 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27680711/dissociating-parafoveal-preview-benefit-and-parafovea-on-fovea-effects-during-reading-a-combined-eye-tracking-and-eeg-study
#12
Florian Niefind, Olaf Dimigen
During reading, the parafoveal processing of an upcoming word n+1 can influence word recognition in two ways: It can affect fixation behavior during the preceding fixation on word n (parafovea-on-fovea effect, POF), and it can facilitate subsequent foveal processing once word n+1 is fixated (preview benefit). While preview benefits are established, evidence for POF effects is mixed. Recently, it has been suggested that POF effects exist, but have a delayed impact on saccade planning and thus coincide with preview benefits measured on word n+1...
December 2016: Psychophysiology
https://www.readbyqxmd.com/read/27650571/reduction-in-the-mrna-expression-of-svegfr1-and-svegfr2-is-associated-with-the-selection-of-dominant-follicle-in-cows
#13
P V Ortega Serrano, A Guzmán, C G Hernández-Coronado, H Castillo-Juárez, A M Rosales-Torres
The vascular endothelial growth factor (VEGF) is essential for follicular development by promoting follicular angiogenesis, as well as for the proliferation and survival of granulosa cells. The biological effects of VEGF are regulated by two membrane receptors, VEGFR1 and VEGFR2, and two soluble receptors, sVEGFR1 and sVEGFR2, which play an antagonistic role. Thus, the objective of this study was to identify the mRNA expression pattern of total VEGF, VEGFR1, VEGFR2, sVEGFR1 and sVEGFR2 in bovine preselected follicles (PRF) and post-selected follicles (POF)...
December 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27647193/hydrogen-rich-water-exerting-a-protective-effect-on-ovarian-reserve-function-in-a-mouse-model-of-immune-premature-ovarian-failure-induced-by-zona-pellucida-3
#14
Xin He, Shu-Yu Wang, Cheng-Hong Yin, Tong Wang, Chan-Wei Jia, Yan-Min Ma
BACKGROUND: Premature ovarian failure (POF) is a disease that affects female fertility but has few effective treatments. Ovarian reserve function plays an important role in female fertility. Recent studies have reported that hydrogen can protect male fertility. Therefore, we explored the potential protective effect of hydrogen-rich water on ovarian reserve function through a mouse immune POF model. METHODS: To set up immune POF model, fifty female BALB/c mice were randomly divided into four groups: Control (mice consumed normal water, n = 10), hydrogen (mice consumed hydrogen-rich water, n = 10), model (mice were immunized with zona pellucida glycoprotein 3 [ZP3] and consumed normal water, n = 15), and model-hydrogen (mice were immunized with ZP3 and consumed hydrogen-rich water, n = 15) groups...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27631223/neutrophil-to-lymphocyte-ratio-predicts-persistent-organ-failure-and-in-hospital-mortality-in-an-asian-chinese-population-of-acute-pancreatitis
#15
Yushun Zhang, Wei Wu, Liming Dong, Chong Yang, Ping Fan, Heshui Wu
Neutrophil to lymphocyte ratio (NLR) has frequently been reported as a significant indicator of systemic inflammation in various medical conditions. The association underlying NLR and outcomes in patients with acute pancreatitis (AP) has not been evaluated after the publication of revised Atlanta classification.This was a single-center retrospective diagnostic accuracy study and a cohort outcome study. From 2009 to 2015, Asian Chinese patients with a diagnosis of AP presented within 72 hours from symptom onset and underwent neutrophil, lymphocyte assessment at presentation were included in this study...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27613321/cytotoxicity-and-genotoxicity-induced-in%C3%A2-vitro-by-solvent-extractable-organic-matter-of-size-segregated-urban-particulate-matter
#16
Ekaterini Velali, Eleni Papachristou, Anastasia Pantazaki, Theodora Choli-Papadopoulou, Nikoleta Argyrou, Theodora Tsourouktsoglou, Stergios Lialiaris, Alexandros Constantinidis, Dimitrios Lykidis, Thedore S Lialiaris, Athanasios Besis, Dimitra Voutsa, Constantini Samara
Three organic fractions of different polarity, including a non polar organic fraction (NPOF), a moderately polar organic fraction (MPOF), and a polar organic fraction (POF) were obtained from size-segregated (<0.49, 0.49-0.97, 0.97-3 and >3 μm) urban particulate matter (PM) samples, and tested for cytotoxicity and genotoxicity using a battery of in vitro assays. The cytotoxicity induced by the organic PM fractions was measured by the mitochondrial dehydrogenase (MTT) cell viability assay applied on MRC-5 human lung epithelial cells...
November 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27515209/is-oral-contraceptive-induced-headache-dependent-on-patent-foramen-ovale-clinical-dynamics-evidence-based-hypothesis-and-possible-patient-oriented-management
#17
Benito Chiofalo, Antonio Simone Laganà, Giovanna Imbesi, Salvatore Giovanni Vitale, Ursula Catena, Federica Campolo, Gabriele Lanzo, Gabriele Centini, Onofrio Triolo
Secondary headache is one of the most common side effect during oral contraceptive (OC) treatment and it leads many patients to stop the therapy. Patent foramen ovale (PFO) is an interatrial communication that spontaneously closes at birth in about 75% of the population. However, in the rest of adults PFO maintains a direct communication between the right and left side of circulation. In these patients PFO is a tunnel-like structure that could allow a blood clot to pass from the right to the left side of circulation, thus can cause paradoxical embolization...
September 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27485835/telocytes-as-potential-targets-in-a-cyclophosphamide-induced-animal-model-of-premature-ovarian-failure
#18
Te Liu, Suwei Wang, Qiong Li, Yongyi Huang, Chuan Chen, Jin Zheng
Premature ovarian failure (POF) refers to the presence of ovarian atrophic permanent amenorrhea in women under the age of 40. The pathogenesis of POF remains to be fully elucidated. Telocytes are a group of specialized cells with a small cell volume and very long cytoplasmic prolongations with dichotomous branching. Previous studies have indicated that telocytes function to support the trachea and serve as stem cell niches. Although it has been confirmed that telocytes are present in numerous organs in mammals, it remains to be determined whether they are present in ovarian tissues and whether they are involved in the development of POF...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27465335/effect-and-mechanism-of-bushen-huoxue-recipe-on-ovarian-reserve-in-mice-with-premature-ovarian-failure
#19
Kun-Kun Song, Wen-Wen Ma, Cong Huang, Jia-Hui Ding, Dan-Dan Cui, Xiu-Juan Tan, Jing Xiao, Ming-Min Zhang
The aim of the present study was to explore the effect and mechanism of Bushen Huoxue recipe (BHR) on ovarian reserve in mice with premature ovarian failure (POF). Mice were divided into 3 groups: normal group, model group and BHR group. Intraperitoneal injection of cyclophosphamide was performed to create the POF model. Primordial follicular (PDF) number, ovarian wet weight, ovarian index, and estrous cycle were analyzed to evaluate the effect of BHR on POF. Meanwhile, the mRNA and protein level of Mouse Vasa Homologue (MVH) in the bone marrow, peripheral blood and ovary were detected, to explore the underlying mechanism of the treatment efficacy of BHR on ovarian reserve...
August 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27414805/foxl2-is-an-essential-activator-of-sf-1-induced-transcriptional-regulation-of-anti-m%C3%A3-llerian-hormone-in-human-granulosa-cells
#20
Hanyong Jin, Miae Won, Si Eun Park, Seunghwa Lee, Mira Park, Jeehyeon Bae
Anti-Müllerian hormone (AMH) is required for proper sexual differentiation by regulating the regression of the Müllerian ducts in males. Recent studies indicate that AMH could be an important factor for maintaining the ovarian reserve. However, the mechanisms of AMH regulation in the ovary are largely unknown. Here, we provide evidence that AMH is an ovarian target gene of steroidogenic factor-1 (SF-1), an orphan nuclear receptor required for proper follicle development. FOXL2 is an evolutionally conserved transcription factor, and its mutations cause blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES), wherein affected females display eyelid defects and premature ovarian failure (POF)...
2016: PloS One
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