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Lijun Ding, Guijun Yan, Bin Wang, Lu Xu, Yan Gu, Tong Ru, Xiaoying Cui, Lei Lei, Jingyu Liu, Xiaoqiang Sheng, Bin Wang, Chunxue Zhang, Yanjun Yang, Ruiwei Jiang, Jianjun Zhou, Na Kong, Feifei Lu, Huaijun Zhou, Yannan Zhao, Bing Chen, Yali Hu, Jianwu Dai, Haixiang Sun
Premature ovarian failure (POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study, umbilical cord mesenchymal stem cells on a collagen scaffold (collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles...
March 13, 2018: Science China. Life Sciences
Peijuan Wang, Yan Lu, Si Chen, Yue Chen, Chunping Hu, Yawei Zuo
Autoimmune abnormality is one of the main causes of premature ovarian failure (POF). Bu Shen Huo Xue formula (BSHXF), a traditional Chinese medicine formula, has been clinically used for the treatment of patients with POF in China. Regulatory T cells (Tregs) are important in the pathogenesis of autoimmune POF. The aim of the present study was to evaluate the immunoprotective effects of BSHXF on POF and the underlying mechanisms. An experimental autoimmune POF model was induced in B6AF1 mice with zona pellucida 3 (ZP3) fragments...
April 2018: Experimental and Therapeutic Medicine
Natalia Pascuali, Leopoldina Scotti, Mariana Di Pietro, Gonzalo Oubiña, Diana Bas, María May, Antonio Gómez Muñoz, Patricia S Cuasnicú, Débora J Cohen, Marta Tesone, Dalhia Abramovich, Fernanda Parborell
STUDY QUESTION: Is ceramide-1-phosphate (C1P) an ovarian protective agent during alkylating chemotherapy? SUMMARY ANSWER: Local administration of C1P drastically reduces ovarian damage induced by cyclophosphamide (Cy) via protection of follicular reserve, restoration of hormone levels, inhibition of apoptosis and improvement of stromal vasculature, while protecting fertility, oocyte quality and uterine morphology. WHAT IS KNOWN ALREADY: Cancer-directed therapies cause accelerated loss of ovarian reserve and lead to premature ovarian failure (POF)...
March 9, 2018: Human Reproduction
Arnaldo Leal-Junior, Anselmo Frizera, Carlos Marques, Maria José Pontes
This paper presents a polymer-optical-fiber (POF)-based sensor system for simultaneous measurement of angle and temperature. The main contribution is obtaining a sensor with higher temperature sensitivity and lower hysteresis on the angle measurements. The annealing was made on the fibers under the conditions of low relative humidity and under water, and a third set of samples without any heat treatment was applied for comparison with the annealed ones. Results of temperature and angle characterization show that the fibers annealed under water presented higher temperature sensitivity and lower errors when compared with the fibers annealed with low humidity or the fibers without annealing...
March 1, 2018: Applied Optics
Anping Cao, Meixia Shan, Laura Paltrinieri, Wiel H Evers, Liangyong Chu, Lukasz Poltorak, Johan H Klootwijk, Beatriz Seoane, Jorge Gascon, Ernst J R Sudhölter, Louis C P M de Smet
Recently various porous organic frameworks (POFs, crystalline or amorphous materials) have been discovered, and used for a wide range of applications, including molecular separations and catalysis. Silicon nanowires (SiNWs) have been extensively studied for diverse applications, including as transistors, solar cells, lithium ion batteries and sensors. Here we demonstrate the functionalization of SiNW surfaces with POFs and explore its effect on the electrical sensing properties of SiNW-based devices. The surface modification by POFs was easily achieved by polycondensation on amine-modified SiNWs...
March 9, 2018: Nanoscale
Cai-Rong Zhang, Ji-Li Deng, Wei-Na Zhu, Ming-Xing Miao, Wei-Wei Shen, Sheng-Jun Cao, Yong Tang
OBJECTIVE: To study the protective effect of moxibustion for tripterygium-induced premature ovarian failure (POF) and its underlying mechanisms in rats. METHODS: Forty-five female SD rats were randomly divided into normal control, POF model and moxibustion groups ( n =15/group). The POF model was induced by intragastric administration of Triptolide (40 mg/kg), once daily for 6 weeks. From the 4th week after modeling, moxibustion was given at "Guanyuan" (CV 4) and bilateral "Sanyinjiao" (SP 6) for 10 min, once daily for 3 weeks...
February 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Lisa C Hickman, Natalia C Llarena, Lindsey N Valentine, Xiaobo Liu, Tommaso Falcone
PURPOSE: To evaluate the available randomized controlled trials (RCTs) in the literature investigating the use of gonadotropin-releasing hormone agonist (GnRHa) co-treatment for ovarian preservation in women receiving chemotherapy. METHODS: A systematic review of the literature was performed from 1960 through 2017 to identify relevant RCTs. Included patients had lymphoma, ovarian cancer, or breast cancer. The primary outcome was the proportion of women who retained ovarian function after chemotherapy...
February 22, 2018: Journal of Assisted Reproduction and Genetics
Ariadny da S Arcas, Fábio da S Dutra, Regina C S B Allil, Marcelo M Werneck
Escherichia coli ( E. coli ) is a large and diverse bacteria group that inhabits the intestinal tract of many mammals. Most E. coli strains are harmless, however some of them are pathogenic, meaning they can make one sick if ingested. By being in the feces of animals and humans, its presence in water and food is used as indicator of fecal contamination. The main method for this microorganism detection is the bacterial culture medium that is time-consuming and requires a laboratory with specialized personnel...
February 22, 2018: Sensors
Zhongshuai Sun, Hui Zhang, Xi Wang, Qiao-Chu Wang, Chuanchao Zhang, Jiu-Qiang Wang, Yi-Han Wang, Chao-Qiang An, Ke-Yan Yang, Yun Wang, Fei Gao, Caixia Guo, Tie-Shan Tang
TMCO1 (transmembrane and coiled-coil domains 1) is an endoplasmic reticulum (ER) transmembrane protein that actively prevents Ca2+ stores from overfilling. To characterize its physiological function(s), we generated Tmco1-/- knockout (KO) mice. In addition to the main clinical features of human cerebrofaciothoracic (CFT) dysplasia spectrum, Tmco1-/- females manifest gradual loss of ovarian follicles, impaired ovarian follicle development, and subfertility with a phenotype analogous to the premature ovarian failure (POF) in women...
February 21, 2018: Cell Death and Differentiation
Chen Wang, Xing-Fei Yu
In recent decades, the incidence rate of breast cancer has increased dramatically worldwide and has become one of the most prevalent cancers in women. According to the global data provided by the WHO, there were more than 1.7 million new cases of breast cancer in 2012, accounting for 25% of all reported cancer cases and 15% of all reported deaths among females. To most young patients, especially those younger than 40 years of age, chemotherapy should be taken into consideration as a treatment modality, even if the tumor size is small or without lymphatic metastasis...
January 2018: Discovery Medicine
Shaik Hasanuddin, Yempati Malleshwar
The use of the term "fibroma" for any soft-tissue lesion or gingival lesion by general practitioners has led to inadequate diagnosis of quite a few rare entities. The occurrence of gingival lesions in adolescent female patients is a routine clinical finding. The site of occurrence of such a lesion is of prime significance, as the rarity of these lesions is determined by the site and size of the lesion. On the other hand, the dilemma over the diagnosis of peripheral ossifying fibroma (POF) versus peripheral odontogenic fibroma still continues...
July 2017: Journal of Indian Society of Periodontology
Biji Babu, Kaveri Hallikeri
Objective: This study reviews, analyzes, and compares the demographic data, histopathological features and discusses the treatment and prognosis of reactive lesions (RLs). Materials and Methods: Retrospective study was performed on the departmental archives from July 2006 to July 2016 (total 5000 cases) comprising of 659 cases of RLs of the oral cavity. The recorded data included age, gender, size, site, duration, habits, etiology, histopathological diagnosis, treatment, and prognosis...
July 2017: Journal of Indian Society of Periodontology
Na Yin, Yanlin Wang, Xueyan Lu, Ranran Liu, Lianshuang Zhang, Wei Zhao, Wendan Yuan, Qianqian Luo, Hao Wu, Xiying Luan, Hongqin Zhang
BACKGROUND: Human placenta-derived mesenchymal stem cell (hPMSC) transplantation has been demonstrated to be an effective way of recovering ovarian function in mice with autoimmune induced premature ovarian failure (POF). But the exact mechanism remains unclear. The goal of the present study is to investigate the role of immune factors (T-helper 17 (Th17), cytotoxic T (Tc17) and regulatory T (Treg) cells) in the recovery of ovarian function and whether the phosphatidylinositol 3-kinase (PI3K)/Akt signal pathway is involved in the regulation...
February 14, 2018: Stem Cell Research & Therapy
Anna Hrabia, Joanna K Socha, Andrzej Sechman
The study was undertaken to examine mRNA expression and localization of selected matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), and the activity of MMPs in chicken postovulatory follicles (POFs) during their apoptotic regression. Apoptotic cells and apoptosis-related caspase expression and activity were examined as well. Chickens were sacrificed 2 h and 21 h after ovulation, and five POFs (POF1 to POF5) were isolated from the ovaries. It was found that the number of apoptotic cells (TUNEL-positive) increased along with follicle regression...
February 10, 2018: General and Comparative Endocrinology
Zhengjie Yan, Youjin Dai, Heling Fu, Yuan Zheng, Dan Bao, Yuan Yin, Qin Chen, Xiaowei Nie, Qingting Hao, Daorong Hou, Yugui Cui
This study was designed to investigate the protective effect of curcumin against D-galactose (D-gal)-induced premature ovarian failure (POF) in mice. A mouse POF model was induced by subcutaneous injection of D-gal (200 daily for 42 days. Mice in the curcumin group received both D-gal treatment and intraperitoneal injection of curcumin (100 for 42 days. Ovarian function, oxidative stress and apoptosis were evaluated. The P, E2 and SOD levels were higher, and the FSH, LH and MDA levels were significantly lower in the curcumin group than in the D-gal group...
February 7, 2018: Journal of Molecular Endocrinology
C A F Marques, R Min, A Leal Junior, P Antunes, A Fasano, G Woyessa, K Nielsen, H K Rasmussen, B Ortega, O Bang
This paper presents fiber Bragg grating (FBG) inscription with a pulsed 248 nm UV KrF laser in polymer optical fibers (POFs) made of different polymers, namely polymethyl methacrylate (PMMA), cyclic-olefin polymer and co-polymer, and Polycarbonate. The inscribed gratings and the corresponding inscription parameters are compared with grating inscribed in POFs made of the aforementioned materials but with the hitherto most used laser for inscription, which is a continuous wave 325 nm UV HeCd laser. Results show a reduction of the inscription time of at least 16 times...
January 22, 2018: Optics Express
Anjali Narwal, Shashi Bala
Background and Objective: Reactive proliferations of oral cavity comprise pyogenic granuloma (PG), fibrous hyperplasia (FH), peripheral ossifying fibroma (POF), and peripheral giant-cell granuloma (PGCG). They often pose diagnostic challenges due to their overlapping clinical and histopathological features. This study was conducted to determine the frequency and clinicopathological correlation of reactive hyperplastic lesions in the oral cavity reported in our institute and compared it with other previous studies...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
Hongqin Zhang, Qianqian Luo, Xueyan Lu, Na Yin, Dongli Zhou, Lianshuang Zhang, Wei Zhao, Dong Wang, Pengchao Du, Yun Hou, Yan Zhang, Wendan Yuan
BACKGROUND: This study was performed to determine the effects of human placenta mesenchymal stem cell (hPMSC) transplantation on granulosa cell apoptosis and anti-Müllerian hormone (AMH) and follicle-stimulating hormone receptor (FSHR) expression in autoimmune drug-induced premature ovarian failure (POF) mice. The aim of this research is to investigate the mechanisms of hPMSCs on ovarian reserve capacity. METHODS: The POF mice model was established by injection of zona pellucida 3 peptide (pZP3)...
January 31, 2018: Stem Cell Research & Therapy
Arnaldo Leal-Junior, Anselmo Frizera-Netoc, Carlos Marques, Maria José Pontes
This paper presents a polymer optical fiber (POF)-based temperature sensor. The operation principle of the sensor is the variation in the POF mechanical properties with the temperature variation. Such mechanical property variation leads to a variation in the POF output power when a constant stress is applied to the fiber due to the stress-optical effect. The fiber mechanical properties are characterized through a dynamic mechanical analysis, and the output power variation with different temperatures is measured...
January 19, 2018: Sensors
Fang Li, Peiwei Chai, Jiayan Fan, Xi Wang, Wenjuan Lu, Jin Li, Shengfang Ge, Renbing Jia, He Zhang, Xianqun Fan
BACKGROUND/AIMS: Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is a rare autosomal dominant disease caused by FOXL2 gene mutations, and it is clinically characterized by an eyelid malformation associated (type I) or not (type II) with premature ovarian failure (POF). Functional study of novel mutations is especially critical for female patients, as it may allow the prediction of infertility and early planning of an appropriate therapy. METHODS: A clinical and molecular genetic investigation was performed in all members of a Chinese family with BPES...
2018: Cellular Physiology and Biochemistry
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