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https://www.readbyqxmd.com/read/29150105/for-survival-the-emergence-of-oligoclonal-bands-after-multiple-myeloma-treatment-is-less-important-than-achieving-complete-remission
#1
Luiza Soares Vieira da Silva, Edvan de Queiroz Crusoe, Lais Rocha Guimarães de Souza, Carlos Sérgio Chiattone, Vânia Tietsche de Moraes Hungria
BACKGROUND: The emergence of oligoclonal bands, proteins differing from those originally identified at diagnosis, has been reported in multiple myeloma patients after high-dose chemotherapy followed by autologous stem cell transplantation and after successful conventional chemotherapy. The clinical relevance of oligoclonal bands remains unclear, but their emergence has been associated with better prognosis. The aim of the present study was to determine the prevalence, clinical characteristics and prognostic impact of the presence of oligoclonal bands in multiple myeloma patients...
October 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/29143589/biomarkers-in-the-evolution-of-multiple-sclerosis
#2
Thomas Berger
Nonimaging biomarkers can be applied in differential diagnosis, evaluation of disease progression and therapy monitoring of multiple sclerosis (MS). Presence of oligoclonal IgG bands in cerebrospinal fluid is a diagnostic element and a negative predictor of MS evolution. AQP4 antibodies are pathogenic and diagnostic for neuromyelitis optica spectrum disorder. Antibodies to myelin oligodendrocyte glycoprotein develop in about 50% of predominantly pediatric patients with acute disseminated encephalomyelitis, but their possible role in pathogenesis is unknown...
November 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29141828/alternative-diagnoses-in-patients-referred-to-specialized-centers-for-suspected-ms
#3
B I Yamout, S J Khoury, N Ayyoubi, H Doumiati, M Fakhreddine, S F Ahmed, H Tamim, J Y Al-Hashel, R Behbehani, R Alroughani
OBJECTIVES: The aim of this study is to explore the frequency, type, and predictors of alternative diagnoses among patients referred with a recent diagnosis of multiple sclerosis (MS) to two specialized MS centers in the Middle East. METHODS: This is a retrospective review of a prospectively followed cohort of MS patients at 2 University specialized MS centers. All patients referred for MS were included. The final diagnosis was recorded and demographic, clinical, laboratory, electrophysiological and radiological variables were collected...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141822/epidemiological-and-clinical-characteristics-of-multiple-sclerosis-in-paediatric-population-in-slovenia-a-descriptive-nation-wide-study
#4
Neli Bizjak, Damjan Osredkar, Mirjana Perković Benedik, Saša Šega Jazbec
BACKGROUND: Although multiple sclerosis usually affects young adults, paediatric-onset multiple sclerosis (pMS) is increasingly recognized in the past ten years. The aim of the present study was to evaluate the incidence of pMS in Slovenia and to characterize the clinical, laboratory and neuroradiological characteristics of pMS at the disease onset. METHODS: We performed a national retrospective descriptive study including all patients diagnosed with pMS between January 1992 and June 2017...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29132035/brain-volume-in-early-ms-patients-with-and-without-igg-oligoclonal-bands-in-csf
#5
G Fenu, L Lorefice, V Sechi, L Loi, F Contu, F Cabras, G Coghe, J Frau, M A Secci, C Melis, L Schirru, G Costa, V Melas, M Arru, M A Barracciu, M G Marrosu, E Cocco
BACKGROUND: Oligoclonal bands of IgG (OB) are proposed as an early prognostic factor of the disease. Growing attention is directed towards brain volume evaluation as a possible marker of the severity of MS. Previous studies found that MS patients lacking OB have less brain atrophy. AIM: to evaluate a possible relationship between OB and cerebral volume in a cohort of early MS patients. METHODS: Inclusion criteria were: diagnosis of relapsing-remitting MS; CSF analysis and MRI acquired simultaneously and within 12 months from clinical onset...
November 8, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29090380/central-nervous-system-aquaporin4-autoimmunity-revealed-by-a-single-pseudotumoral-encephalic-lesion
#6
Guillaume Fargeot, J Aboab, J Savatovsky, R Marignier, A Lecler, O Gout
The radiological spectrum of neuromyelitis optica has become broader since the detection of aquaporin4 antibodies. We report a case of neuromyelitis optica patient with pseudotumoral encephalic lesion. A 66 year-old woman presented with sudden left lateral homonymous hemianopsia. A brain MRI showed an isolated and extensive right temporo-parieto-occipital lesion, involving periventricular white matter and the corpus callosum, with strong enhancement on post-gadolinium T1 weighted images, highly suggestive of lymphoma...
October 31, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29059249/the-complex-relationship-between-oligoclonal-bands-lymphocytes-in-the-cerebrospinal-fluid-and-immunoglobulin-g-antibodies-in-multiple-sclerosis-indication-of-serum-contribution
#7
Cheryl Beseler, Timothy Vollmer, Michael Graner, Xiaoli Yu
INTRODUCTION: Intrathecal immunoglobulin G (IgG) and oligoclonal bands (OCBs) are the most consistent and characteristic features of Multiple Sclerosis (MS). OCBs in MS are considered products of clonally expanded B cells in the cerebrospinal fluid (CSF), representing the sum of contributions from B cells in the brain. However, large amounts of IgG can be eluted from MS plaques in which lymphocytes are absent, and there is no correlation between levels of plaque-associated IgG and the presence of lymphocytes...
2017: PloS One
https://www.readbyqxmd.com/read/29055436/brain-white-matter-demyelinating-lesions-and-amyotrophic-lateral-sclerosis-in-a-patient-with-c9orf72-hexanucleotide-repeat-expansion
#8
Miguel Oliveira Santos, Inês Caldeira, Marta Gromicho, Ana Pronto-Laborinho, Mamede de Carvalho
A hexanucleotide repeat expansion in the C9orf72 gene is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. It has been described before four patients with multiple sclerosis (MS) and C9orf72-ALS. However, C9orf72 positivity is not associated with increased risk of MS. Inflammatory pathways related to NF-κB have been linked to ALS and MS, and appear to be important in C9orf72-ALS patients. A 42-year-old woman presented with progressive bulbar symptoms for 9 months. Neurological examination disclosed spastic dysarthria, atrophic tongue with fasciculations, brisk jaw and limb tendon reflexes, and bilateral Hoffman sign...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29030765/cerebrospinal-fluid-analysis-and-the-determination-of-oligoclonal-bands
#9
REVIEW
Matteo Gastaldi, Elisabetta Zardini, Rosaria Leante, Maddalena Ruggieri, Gianna Costa, Eleonora Cocco, Giovanna De Luca, Ivana Cataldo, Tiziana Biagioli, Clara Ballerini, Massimiliano Castellazzi, Enrico Fainardi, Paola Pettini, Mauro Zaffaroni, Debora Giunti, Elisabetta Capello, Gaetano Bernardi, Emilio Ciusani, Claudia Giannotta, Eduardo Nobile-Orazio, Elena Bazzigaluppi, Gabriella Passerini, Roberta Bedin, Patrizia Sola, Rinaldo Brivio, Guido Cavaletti, Arianna Sala, Antonio Bertolotto, Gaetano Desina, Maurizio A Leone, Sara Mariotto, Sergio Ferrari, Andreina Paternoster, Davide Giavarina, Francesco Lolli, Diego Franciotta
This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroinflammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists...
October 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28991721/clinical-and-imaging-correlation-in-patients-with-pathologically-confirmed-tumefactive-demyelinating-lesions
#10
Matthew A Tremblay, Javier E Villanueva-Meyer, Soonmee Cha, Tarik Tihan, Jeffrey M Gelfand
OBJECTIVES: To characterize clinical and imaging features in patients with pathologically confirmed demyelinating lesions. METHODS: In this retrospective chart review, we analyzed clinical-radiological-pathological correlations in patients >15years old who underwent brain biopsy at our institution between 2000 and 2015 and had inflammatory demyelination on neuropathology. RESULTS: Of 31 patients, the mean age was 42years (range 16 to 69years) and 55% were female...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28987645/tumefactive-demyelinating-lesions-tdls-a-case-series-of-clinicoradiological-features
#11
Rajendra Singh Jain, Ibraheem Khan, Kapil Kandelwal, Tushar Desai
OBJECTIVE: Diagnosis of tumefactive demyelination lesions (TDLs) is challenging to neurophysician, neuroradiologist or neurosurgeon. Our objective in this study was to analyze clinicoradiological features of TDLs. PATIENTS AND METHOD: A retrospective analysis with prospective follow-up of 11 cases of TDLs was performed. Study was conducted in the neurology department of a tertiary care centre of North-West India from August 2014 to March 2017. MRI of brain and cervical spine with contrast, visual evoked potential, oligoclonal bands, serum anti-AQP4 antibody and MRS performed in most of the patients...
November 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28984755/clinical-and-imaging-features-of-spinal-cord-type-of-neuro-beh%C3%A3-et-disease-a-case-report-and-systematic-review
#12
REVIEW
Hui-Miao Liu, Ci Dong, Yong-Zhi Zhang, Ya-Yun Tian, Hong-Xu Chen, Sai Zhang, Na Li, Ping Gu
RATIONAL: To investigate the clinical and MRI characteristics of spinal cord nerve Behçet's disease. PATIENT CONCERNS: One patient with spinal cord nerve Behçet's disease was admitted to our hospital at October 20, 2015. DIAGNOSE: Spinal cord nerve Behçet's disease. INTERVENTIONS: Retrospective analysis was performed on such case as well as 16 cases of spinal cord nerve Behçet's disease reported in China or abroad...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28959704/cryptogenic-norse-its-distinctive-clinical-features-and-response-to-immunotherapy
#13
Takahiro Iizuka, Naomi Kanazawa, Juntaro Kaneko, Naomi Tominaga, Yutaka Nonoda, Atsuko Hara, Yuya Onozawa, Hiroki Asari, Takashi Hata, Junya Kaneko, Kenji Yoshida, Yoshihiro Sugiura, Yoshikazu Ugawa, Masashi Watanabe, Hitomi Tomita, Arifumi Kosakai, Atsushi Kaneko, Daisuke Ishima, Eiji Kitamura, Kazutoshi Nishiyama
OBJECTIVE: To report the distinctive clinical features of cryptogenic new-onset refractory status epilepticus (C-NORSE) and the C-NORSE score based on initial clinical assessments. METHODS: A retrospective study was conducted for 136 patients with clinically suspected autoimmune encephalitis who underwent testing for autoantibodies to neuronal surface antigens between January 1, 2007, and August 31, 2016. Eleven patients with C-NORSE were identified. Their clinical features were compared with those of 32 patients with anti-NMDA receptor encephalitis (NMDARE)...
November 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28959703/radiologically-isolated-syndrome-in-children-clinical-and-radiologic-outcomes
#14
Naila Makhani, Christine Lebrun, Aksel Siva, David Brassat, Clarisse Carra Dallière, Jérôme de Seze, Wei Du, Françoise Durand Dubief, Orhun Kantarci, Megan Langille, Sona Narula, Jean Pelletier, Juan Ignacio Rojas, Eugene D Shapiro, Robert T Stone, Mar Tintoré, Ugur Uygunoglu, Patrick Vermersch, Evangeline Wassmer, Darin T Okuda, Daniel Pelletier
OBJECTIVE: To describe clinical and radiologic outcomes of children with incidental findings on neuroimaging suggestive of CNS demyelination (termed "radiologically isolated syndrome" or RIS). METHODS: Clinical and radiologic data were obtained from a historical cohort of children with no symptoms of demyelinating disease who had MRI scans that met the 2010 MRI criteria for dissemination in space for MS. RESULTS: We identified 38 children (27 girls and 11 boys) with RIS now being prospectively followed at 16 sites in 6 countries...
November 2017: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/28959231/demographic-clinical-and-immunologic-features-of-389-children-with-opsoclonus-myoclonus-syndrome-a-cross-sectional-study
#15
Michael R Pranzatelli, Elizabeth D Tate, Nathan R McGee
Pediatric-onset opsoclonus-myoclonus syndrome (OMS) is a devastating neuroinflammatory, often paraneoplastic, disorder. The objective was to characterize demographic, clinical, and immunologic aspects in the largest cohort reported to date. Cross-sectional data were collected on 389 children in an IRB-approved, observational study at the National Pediatric Myoclonus Center. Non-parametric statistical analysis was used. OMS manifested in major racial/ethnic groups, paralleling US population densities. Median onset age was 1...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28953254/clinically-isolated-syndrome-according-to-mcdonald-2010-intrathecal-igg-synthesis-still-predictive-for-conversion-to-multiple-sclerosis
#16
Philipp Schwenkenbecher, Anastasia Sarikidi, Lena Bönig, Ulrich Wurster, Paul Bronzlik, Kurt-Wolfram Sühs, Refik Pul, Martin Stangel, Thomas Skripuletz
While the revised McDonald criteria of 2010 allow for the diagnosis of multiple sclerosis (MS) in an earlier stage, there is still a need to identify the risk factors for conversion to MS in patients with clinically isolated syndrome (CIS). Since the latest McDonald criteria were established, the prognostic role of cerebrospinal fluid (CSF) and visual evoked potentials (VEP) in CIS patients is still poorly defined. We conducted a monocentric investigation including patients with CIS in the time from 2010 to 2015...
September 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28912918/prospective-identification-of-oligoclonal-abnormal-band-of-the-same-immunoglobulin-type-as-the-malignant-clone-by-differential-location-of-m-spike-and-oligoclonal-band
#17
Shikhar G Vyas, Gurmukh Singh
BACKGROUND: Serum and urine protein electrophoreses and immunofixation electrophoreses are the gold standards in diagnosing monoclonal gammopathy. Identification of oligoclonal bands in post-treatment patients has emerged as an important issue and recording the location of the malignant monoclonal peak may facilitate prospective identification of a new "monoclonal" spike as being distinct from the malignant peak. METHODS: We recorded the locations of monoclonal spikes in descriptive terms, such as being in the cathodal region, mid-gamma region, anodal region, and beta region...
October 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28903961/paediatric-optic-neuritis-factors-leading-to-unfavourable-outcome-and-relapses
#18
Delphine Averseng-Peaureaux, Marie Mizzi, Helene Colineaux, Laurence Mahieu, Maria Carmela Pera, David Brassat, Yves Chaix, Emilie Berard, Kumaran Deiva, Emmanuel Cheuret
OBJECTIVES: To identify prognostic factors associated with poor visual recovery and chronic relapsing diseases, for example, multiple sclerosis (MS), in children with optic neuritis (ON) at onset. METHODS: This multicentre retrospective study included 102 children with a first ON episode between 1990 and 2012. The primary criterion was poor visual recovery determined by visual acuity, and the secondary was relapses following ON. RESULTS: Median age was 11 years, 66% were girls and mean follow-up was 24 months...
September 13, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28860940/limbic-encephalitis-a%C3%A2-report-of-four-cases
#19
Żanna Pastuszak, Adam Stępień, Kazimierz Tomczykiewicz, Renata Piusińska-Macoch, Joanna Kordowska, Dariusz Galbarczyk, Jarosław Świstak
Usually limbic encephalitis (LE) is a paraneoplastic neurologic syndrome. LE symptoms can precede cancer even by a few years. Almost 50% of LE cases are connected with small cell lung carcinoma. Testis and breast cancers, granulomatous disease, thymoma, and teratomas are also often connected with LE. Other cases have infectious and autoimmunological aetiology. In LE limbic system dysfunction is observed, and it is accompanied by cerebellum and brain stem abnormalities as well as polyneuropathy. Paraneoplastic limbic encephalitis is sometimes a part of larger syndrome in which brain stem and spinal cord are involved in an inflammatory process called paraneoplastic encephalomyelitis...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/28851393/pattern-ii-and-pattern-iii-ms-are-entities-distinct-from-pattern-i-ms-evidence-from-cerebrospinal-fluid-analysis
#20
S Jarius, F B König, I Metz, K Ruprecht, F Paul, W Brück, B Wildemann
BACKGROUND: The diagnosis of multiple sclerosis (MS) is currently based solely on clinical and magnetic resonance imaging features. However, histopathological studies have revealed four different patterns of lesion pathology in patients diagnosed with MS, suggesting that MS may be a pathologically heterogeneous syndrome rather than a single disease entity. OBJECTIVE: The aim of this study was to investigate whether patients with pattern I MS differ from patients with pattern II or III MS with regard to cerebrospinal fluid (CSF) findings, especially with reference to intrathecal IgG synthesis, which is found in most patients with MS but is frequently missing in MS mimics such as aquaporin-4-IgG-positive neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein-IgG-positive encephalomyelitis...
August 29, 2017: Journal of Neuroinflammation
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