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https://www.readbyqxmd.com/read/28528409/polychlorinated-biphenyl-related-alterations-of-the-expression-of-essential-genes-in-harbour-seals-phoca-vitulina-from-coastal-sites-in-canada-and-the-united-states
#1
Marie Noël, Neil Dangerfield, Steve Jeffries, Dyanna Lambourn, Monique Lance, Caren Helbing, Michel Lebeuf, Peter S Ross
As long-lived marine mammals found throughout the temperate coastal waters of the North Pacific and Atlantic Oceans, harbour seals (Phoca vitulina) have become an invaluable sentinel of food-web contamination. Their relatively high trophic position predisposes harbour seals to the accumulation of harmful levels of persistent organic pollutants (POPs). We obtained skin/blubber biopsy samples from live-captured young harbour seals from various sites in the northeastern Pacific (British Columbia, Canada, and Washington State, USA) as well as the northwestern Atlantic (Newfoundland and Quebec, Canada)...
May 20, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28497985/examining-medical-student-specialty-choice-through-a-gender-lens-an-orientational-qualitative-study
#2
Victoria Smith, Cheri Bethune, Katrina F Hurley
Phenomenon: A growing number of women are entering the medical workforce, yet their distribution across medical specialties remains nonuniform. We sought to describe how culture, bias, and socialization shape gendered thinking regarding specialty choice at a Canadian undergraduate medical institution. APPROACH: We analyzed transcripts from the Career Choices Project: 16 semistructured focus group discussions with 70 students graduating from Memorial University of Newfoundland in 2003, 2006, 2007, and 2008...
May 12, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28488356/early-life-traits-of-farm-and-wild-atlantic-salmon-salmo-salar-and-first-generation-hybrids-in-the-south-coast-of-newfoundland
#3
D Hamoutene, J Perez-Casanova, K Burt, L Lush, J Caines, C Collier, R Hinks
This study examined fertilization rates, survival and early life-trait differences of pure farm, wild and first generation (F1) hybrid origin embryos after crossing farm and wild Atlantic salmon Salmo salar. Results show that despite a trend towards higher in vitro fertilization success for wild females, differences in fertilization success in river water are not significantly different among crosses. In a hatchery environment, wild females' progeny (pure wild and hybrids with wild maternal parent) hatched 7-11 days earlier than pure farm crosses and hybrids with farm maternal parents...
May 9, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28483888/alignment-of-canadian-primary-care-with-the-patient-medical-home-model-a-qualico-pc-study
#4
Alan Katz, Nicole Herpai, Glenys Smith, Kris Aubrey-Bassler, Mylaine Breton, Antoine Boivin, William Hogg, Baukje Miedema, Jocelyn Pang, Walter P Wodchis, Sabrina T Wong
PURPOSE: The patient medical home (PMH) model aims to improve patient satisfaction and health outcomes in Canada, but since its introduction in 2009, there has been no evaluation of the extent to which primary care conforms with PMH attributes. Our objective was to compare current primary care across Canada with the 10 goals of the PMH model. METHODS: A cross-sectional survey of primary care organization and delivery was conducted in Canadian provinces to evaluate the PMH-based attributes of primary care practices...
May 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28480025/selection-and-drift-influence-genetic-differentiation-of-insular-canada-lynx-lynx-canadensis-on-newfoundland-and-cape-breton-island
#5
Melanie B Prentice, Jeff Bowman, Kamal Khidas, Erin L Koen, Jeffrey R Row, Dennis L Murray, Paul J Wilson
Island populations have long been important for understanding the dynamics and mechanisms of evolution in natural systems. While genetic drift is often strong on islands due to founder events and population bottlenecks, the strength of selection can also be strong enough to counteract the effects of drift. Here, we used several analyses to identify the roles of genetic drift and selection on genetic differentiation and diversity of Canada lynx (Lynx canadensis) across eastern Canada, including the islands of Cape Breton and Newfoundland...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28480021/population-structure-of-purple-sandpipers-calidris-maritima-as-revealed-by-mitochondrial-dna-and-microsatellites
#6
Nathalie M LeBlanc, Donald T Stewart, Snaebjörn Pálsson, Mark F Elderkin, Glen Mittelhauser, Stephen Mockford, Julie Paquet, Gregory J Robertson, Ron W Summers, Lindsay Tudor, Mark L Mallory
The Purple Sandpiper (Calidris maritima) is a medium-sized shorebird that breeds in the Arctic and winters along northern Atlantic coastlines. Migration routes and affiliations between breeding grounds and wintering grounds are incompletely understood. Some populations appear to be declining, and future management policies for this species will benefit from understanding their migration patterns. This study used two mitochondrial DNA markers and 10 microsatellite loci to analyze current population structure and historical demographic trends...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28471781/evaluation-of-and-feedback-for-academic-medicine-leaders-developing-and-implementing-the-memorial-method
#7
James Rourke, Stephen Bornstein, Cathy Vardy, David Speed, Tyrone White, Paula Corbett
PROBLEM: Giving and receiving honest and helpful feedback for leadership development is a common challenge in all types of organizations but particularly in academic medicine. APPROACH: At Memorial University of Newfoundland, in 2014, a consensus emerged to develop a new method for evaluating the leadership performance of the discipline chairs, dean, and vice dean, and to provide these leaders with the evaluation results to help them improve their performance. The leaders responsible for developing and implementing this method (called the Memorial Method) decided to use a survey to obtain faculty members' perceptions about their leader's performance...
May 2, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28469428/using-electronic-medical-record-to-identify-patients-with-dyslipidemia-in-primary-care-settings-international-classification-of-disease-code-matters-from-one-region-to-a-national-database
#8
Justin Oake, Erfan Aref-Eshghi, Marshall Godwin, Kayla Collins, Kris Aubrey-Bassler, Pauline Duke, Masoud Mahdavian, Shabnam Asghari
OBJECTIVE: To assess the validity of the International Classification of Disease (ICD) codes for identifying patients with dyslipidemia in electronic medical record (EMR) data. METHODS: The EMRs of patients receiving primary care in St. John's, Newfoundland and Labrador (NL), Canada, were retrieved from the Canadian Primary Care Sentinel Surveillance Network database. International Classification of Disease codes were first compared with laboratory lipid data as an independent criterion standard, and next with a "comprehensive criterion standard," defined as any existence of abnormal lipid test, lipid-lowering medication record, or dyslipidemia ICD codes...
2017: Biomedical Informatics Insights
https://www.readbyqxmd.com/read/28441128/early-career-work-location-of-memorial-university-medical-graduates-why-the-decline-in-rural-practice
#9
Maria Mathews, Dana Ryan, Asoka Samarasena
INTRODUCTION: In a previous study, we found a decline in the proportion of Memorial University of Newfoundland (MUN) medical alumni practising in rural areas, particularly in Newfoundland and Labrador. The current study focused on the work location of recent graduates and examined the predictors of working in rural Canada and in rural Newfoundland and Labrador within the first 15 years following graduation. METHODS: We linked data from graduating class lists and the alumni and postgraduate databases with Scott's Medical Database to create a record of all graduates from 1973 to 2008, including their work location...
2017: Canadian Journal of Rural Medicine
https://www.readbyqxmd.com/read/28422135/genomic-evidence-of-hybridization-between-two-independent-invasions-of-european-green-crab-carcinus-maenas-in-the-northwest-atlantic
#10
N W Jeffery, C DiBacco, B F Wringe, R R E Stanley, L C Hamilton, P N Ravindran, I R Bradbury
Invasive species have been associated with significant negative impacts in their introduced range often outcompeting native species, yet the long-term evolutionary dynamics of biological invasions are not well understood. Hybridization, either among waves of invasion or between native and introduced populations, could alter the ecological and evolutionary impacts of invasions yet has rarely been studied in marine invasive species. The European green crab (Carcinus maenas) invaded eastern North America twice from northern and southern locations in its native range...
April 19, 2017: Heredity
https://www.readbyqxmd.com/read/28418804/determinants-of-nonmedically-indicated-in-hospital-supplementation-of-infants-whose-birthing-parents-intended-to-exclusively-breastfeed
#11
Julia Temple Newhook, Leigh Anne Newhook, William K Midodzi, Janet Murphy Goodridge, Lorraine Burrage, Nicole Gill, Beth Halfyard, Laurie Twells
BACKGROUND: Despite high rates of intention to exclusively breastfeed, rates of exclusive breastfeeding in Canada are low. Supplementation may begin in hospital and is associated with reduced breastfeeding duration. Research aim: The aim of this investigation was to explore determinants of in-hospital nonmedically indicated supplementation of infants whose birthing parents intended to exclusively breastfeed. METHODS: This study is a cross-sectional one-group nonexperimental design, focused on participants who intended to exclusively breastfeed for 6 months ( n = 496)...
May 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28380029/high-dietary-selenium-intake-is-associated-with-less-insulin-resistance-in-the-newfoundland-population
#12
Yongbo Wang, Meiju Lin, Xiang Gao, Pardis Pedram, Jianling Du, Chandurkar Vikram, Wayne Gulliver, Hongwei Zhang, Guang Sun
As an essential nutrient, Selenium (Se) is involved in many metabolic activities including mimicking insulin function. Data on Se in various biological samples and insulin resistance are contradictory, moreover there is no large study available regarding the relationship of dietary Se intake with insulin resistance in the general population. To investigate the association between dietary Se intake and variation of insulin resistance in a large population based study, a total of 2420 subjects without diabetes from the CODING (Complex Diseases in the Newfoundland Population: Environment and Genetics) study were assessed...
2017: PloS One
https://www.readbyqxmd.com/read/28372589/the-first-canadian-experience-with-the-afirma%C3%A2-gene-expression-classifier-test
#13
Emily Kay-Rivest, Jamie Tibbo, Sarah Bouhabel, Michael Tamilia, Rebecca Leboeuf, Veronique-Isabelle Forest, Michael P Hier, Loren Savoury, Richard J Payne
BACKGROUND: Thyroid nodules are common and often benign, although prove to be malignant upon surgical pathology in 5-15% of cases. When assessed with ultrasound-guided fine-needle aspiration (USFNA), 15-30% of the nodules yield an indeterminate result. The Afirma® gene expression classifier (AGEC) was developed to improve management of indeterminate thyroid nodules (ITNs) by classifying them as "benign" or "suspicious." Objectives were (1) to assess the performance of the AGEC in two Canadian academic medical centres (2), to search for inter-institutional variation and (3) to compare AGEC performance in Canadian versus American institutions...
April 4, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28369873/a-comparison-of-molecular-markers-and-morphology-for-neidium-taxa-bacillariophyta-from-eastern-north-america
#14
Keely E Lefebvre, Paul B Hamilton, Frances R Pick
Historically, a morphological species concept has applied shape subjectively in the delimitation of diatom species. This has led to confusion between taxa within the benthic diatom genus Neidium. Samples from Ontario, Quebec, Nova Scotia, Newfoundland (Canada) and New York (USA) were examined for Neidium taxa under LM and SEM. Fourier shape analysis showed that shape as a taxonomic character was not able to discern all species. Isolated individuals from the samples were amplified and sequenced for three chloroplast molecular markers (rbcL, psbC, and psbA) and one nuclear ribosomal molecular marker (18S)...
March 31, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28359300/highly-localized-divergence-within-supergenes-in-atlantic-cod-gadus-morhua-within-the-gulf-of-maine
#15
Bryan T Barney, Christiane Munkholm, David R Walt, Stephen R Palumbi
BACKGROUND: Atlantic cod (Gadus morhua), is known to vary genetically across the North Atlantic, Greenland, and Newfoundland. This genetic variation occurs both spatially and temporally through decades of heavy fishing, and is concentrated in three linkage disequilibrium blocks, previously defined by pedigreed linkage mapping analysis. Variation within these genomic regions is correlated with both seawater temperature and behavioral ecotype. The full extent and nature of these linkage groups is important information for interpreting cod genetic structure as a tool for future fisheries management...
March 31, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28324114/novel-25-kb-deletion-of-mertk-causes-retinitis-pigmentosa-with-severe-progression
#16
Daniel R Evans, Jane S Green, Gordon J Johnson, Jeremy Schwartzentruber, Jacek Majewski, Chandree L Beaulieu, Wen Qin, Christian R Marshall, Tara A Paton, Nicole M Roslin, Andrew D Paterson, Somayyeh Fahiminiya, Justin French, Kym M Boycott, Michael O Woods
Purpose: Retinitis pigmentosa (RP) describes a complex group of inherited retinal dystrophies with almost 300 reported genes and loci. We investigated the genetic etiology of autosomal recessive RP (arRP) in a large kindred with 5 affected family members, who reside on the island of Newfoundland, Canada. Methods: Genetic linkage analysis was performed on 12 family members (Infinium HumanOmni2.5-8 BeadChip). Whole exome sequencing analysis (Illumina HiSeq) was performed on one affected individual...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28300336/the-second-epidemiologic-transition-on-the-brink-what-we-can-learn-from-the-island-of-newfoundland-during-the-early-20th-century
#17
Dana M Schmidt, Lisa Sattenspiel
OBJECTIVES: We aim to understand how the second epidemiologic transition unfolded on the island of Newfoundland during the early 20th century. The focus is on changes in predominant causes of mortality throughout this period, urban and rural differences, and comparisons with other Western nations. We explore factors driving these patterns including the economy, nutrition, sanitation, and access to healthcare and discuss their relevance to understanding epidemiologic transitions in other developing regions...
March 16, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28284232/engaging-patients-in-health-research-identifying-research-priorities-through-community-town-halls
#18
Holly Etchegary, Lisa Bishop, Catherine Street, Kris Aubrey-Bassler, Dale Humphries, Lidewij Eva Vat, Brendan Barrett
BACKGROUND: The vision of Canada's Strategy for Patient-Oriented Research is that patients be actively engaged as partners in health research. Support units have been created across Canada to build capacity in patient-oriented research and facilitate its conduct. This study aimed to explore patients' health research priorities in the province of Newfoundland and Labrador (NL). METHODS: Eight town halls were held with members of the general public in rural and urban settings across the province...
March 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28273034/evaluating-compression-or-expansion-of-morbidity-in-canada-trends-in-life-expectancy-and-health-adjusted-life-expectancy-from-1994-to-2010
#19
Colin Steensma, Lidia Loukine, Bernard C Choi
INTRODUCTION: The objective of this study was to investigate whether morbidity in Canada, at the national and provincial levels, is compressing or expanding by tracking trends in life expectancy (LE) and health-adjusted life expectancy (HALE) from 1994 to 2010. "Compression" refers to a decrease in the proportion of life spent in an unhealthy state over time. It happens when HALE increases faster than LE. "Expansion" refers to an increase in the proportion of life spent in an unhealthy state that happens when HALE is stable or increases more slowly than LE...
March 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28262470/association-of-early-onset-myasthenia-gravis-in-newfoundland-dogs-with-the-canine-major-histocompatibility-complex-class-i
#20
Zena Wolf, Karen Vernau, Noa Safra, G Diane Shelton, Jason King, Joseph Owen, Kalie Weich, Danika Bannasch
Acquired Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder whose development in humans has been associated with the Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA). There is a form of early onset MG (EOMG) in Newfoundland dogs that mimics the clinical presentation in humans and appears to have familial inheritance. Genotyping of three classical Dog Leukocyte Antigen (DLA) class II genes, DLA-DRB1, DLA-DQA1 and DLA-DQB1, in 16 Newfoundlands with EOMG and 46 unaffected Newfoundlands, identified DLA-DQB1 *00301 (p-value = 0...
May 2017: Neuromuscular Disorders: NMD
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