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https://www.readbyqxmd.com/read/29914578/near-complete-response-to-pembrolizumab-in-microsatellite-stable-metastatic-sebaceous-carcinoma
#1
Evidio Domingo-Musibay, Paari Murugan, Alessio Giubellino, Sandeep Sharma, Daniel Steinberger, Jianling Yuan, Matthew A Hunt, Emil Lou, Jeffrey S Miller
BACKGROUND: Sebaceous carcinoma is an aggressive adnexal skin tumor with a predilection for the eyelids and sebaceous glands of the head and neck. CASE PRESENTATION: A 73 year-old man presented with confusion and was found to have widely disseminated sebaceous carcinoma with metastases to brain, lungs, liver, bowel, lymph nodes, and bone. Following initial treatment of the brain metastases with surgery he received post-operative radiosurgery. He then began systemic immunotherapy with pembrolizumab...
June 19, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29908011/pretransplant-increases-in-left-ventricular-volume-and-mass-are-associated-with-qt-prolongation-during-pediatric-liver-transplantation
#2
Hyun-Seok Cho, Wook-Jong Kim, Byungdoo Andrew Lee, Junki Cho, Won-Jung Shin, Gyu-Sam Hwang
Structural alterations in the cirrhotic heart may contribute to electromechanical abnormalities, represented by QT prolongation. The aim of this study was to investigate the changes in QTc according to the operative stage during pediatric LT and to identify which baseline echocardiographic parameters were associated with intraoperative QTc prolongation. Data were evaluated from 39 children undergoing LT for chronic liver disease (median age 9 months). In 19 patients (48.7%), baseline QTc was prolonged ≥440 ms (462 ± 19 ms)...
June 15, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29907965/the-genetic-architecture-of-diet-induced-hepatic-fibrosis-in-mice
#3
Simon T Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C Davis, Calvin Pan, Darwin L Dirks, Clara E Magyar, Samuel W French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos-Pérez, Nahum Méndez-Sánchez, Luis Macías-Kauffer, Paola León-Mimila, Samuel Canizales-Quinteros, Xia Yang, Simon W Beaven, Adriana Huertas-Vazquez, Aldons J Lusis
We report the genetic analysis of a "humanized" hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis. Mice carrying transgenes for human APOE*3-Leiden and CETP and fed a "Western" diet were studied on the genetic backgrounds of over 100 inbred mouse strains. The mice developed hepatic inflammation and fibrosis that was highly dependent on genetic background, with vast differences in the degree of fibrosis. Histological analysis showed features characteristic of human NASH, including macrovesicular steatosis, hepatocellular ballooning, inflammatory foci and pericellular collagen deposition...
June 16, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29902703/metabolic-liver-inflammation-in-obesity-does-not-robustly-decrease-hepatic-and-circulating-cetp
#4
Lisanne L Blauw, Zhuang Li, Sander S Rensen, Jan Willem M Greve, Aswin Verhoeven, Rico J Derks, Martin Giera, Yanan Wang, Patrick C N Rensen
BACKGROUND AND AIMS: We recently showed that plasma cholesteryl ester transfer protein (CETP) is mainly derived from VSIG4-positive Kupffer cells. Activation of these cells by the bacterial endotoxin lipopolysaccharide (LPS) strongly decreases CETP expression. As Kupffer cell activation plays a detrimental role in the progression of non-alcoholic fatty liver disease (NAFLD), we aimed to study if metabolic liver inflammation is also associated with a decrease in hepatic and circulating CETP...
June 7, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29901618/management-of-hepatic-vein-occlusive-disease-after-liver-transplantation-a-case-report-with-literature-review
#5
Yuchen Hou, Nga Lei Tam, Zhicheng Xue, Xuzhi Zhang, Bing Liao, Jie Yang, Shunjun Fu, Yi Ma, Linwei Wu, Xiaoshun He
RATIONALE: Hepatic vein occlusive disease (HVOD) is a rare complication after liver transplantation, which is characterized by nonthrombotic, fibrous obliteration of the small centrilobular hepatic veins by connective tissue and centrilobular necrosis in zone 3 of the acini. HVOD after solid organ transplantation has been reported; recently, most of these reports with limited cases have documented that acute cell rejection and immunosuppressive agents are the major causative factors. HVOD is relatively a rare complication of liver transplantation with the incidence of approximately 2%...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29900476/mixed-adenoneuroendocrine-carcinoma-of-the-esophagogastric-junction-a-case-report
#6
Miho Yamamoto, Soji Ozawa, Kazuo Koyanagi, Junya Oguma, Akihito Kazuno, Yamato Ninomiya, Kentaro Yatabe, Kazuhito Hatanaka
BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is a tumor of the gastrointestinal tract that contains both exocrine and endocrine components, with each component exceeding 30% of the total tumor area. Because MANECs are exceedingly rare, no therapeutic strategies have been established yet. CASE PRESENTATION: An 81-year-old man was referred to our hospital with a 5-month history of dysphagia. Esophagogastroduodenoscopy revealed an ulcerated mass in the lower thoracic esophagus, extending up to the esophagogastric junction (33 to 40 cm from the incisors)...
June 14, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29893699/impact-of-diabetes-mellitus-and-insulin-on-nonalcoholic-fatty-liver-disease-in-the-morbidly-obese
#7
Cláudia B M Strey, Luiz A de Carli, Marciane Fantinelli, Sabrina S Gobbato, Guilherme F Bassols, Alexandre Losekann, Gabriela P Coral
INTRODUCTION AND AIM: The prevalence of obesity, type 2 diabetes mellitus and non-alcoholic fatty liver disease are increasing. Type 2 diabetes mellitus may aggravate non-alcoholic fatty liver disease, increasing the risk of developing cirrhosis and hepatocellular carcinoma. This study aims to determine the effect of type 2 diabetes mellitus and insulin therapy on non-alcoholic fatty liver disease in the patients with morbid obesity. MATERIAL AND METHODS: Clinical, anthropometric and laboratory data were analyzed together with intraoperative liver biopsies from morbidly obese patients undergoing bariatric surgery...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29891107/surgical-treatment-of-pulmonary-metastasis-in-colorectal-cancer-patients-current-practice-and-results
#8
REVIEW
Matthieu Zellweger, Etienne Abdelnour-Berchtold, Thorsten Krueger, Hans-Beat Ris, Jean Yannis Perentes, Michel Gonzalez
Colorectal cancer (CRC) is a frequently occurring disease, yet diagnosed at a local stage in only 40% of cases. Lung metastases (LM) appear in 5-15% of patients and, left untreated, carry a very poor prognosis. Some CRC patients may benefit from a potentially curative LM resection, but success and benefit are difficult to predict. We discuss prognostic factors of survival after lung metastasectomy in CRC patients under several scenarios (with/ without prior liver metastases; repetitive pulmonary resections)...
July 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29889191/utilization-of-ultrasound-guided-tissue-directed-cellular-implantation-for-the-establishment-of-biologically-relevant-metastatic-tumor-xenografts
#9
Tina T Thomas, Sahiti Chukkapalli, Raelene A Van Noord, Melanie Krook, Mark J Hoenerhoff, Jonathan R Dillman, Elizabeth R Lawlor, Valerie P Opipari, Erika A Newman
Preclinical testing of anticancer therapies relies on relevant xenograft models that mimic the innate tendencies of cancer. Advantages of standard subcutaneous flank models include procedural ease and the ability to monitor tumor progression and response without invasive imaging. Such models are often inconsistent in translational clinical trials and have limited biologically relevant characteristics with low proclivity to produce metastasis, as there is a lack of a native microenvironment. In comparison, orthotopic xenograft models at native tumor sites have been shown to mimic the tumor microenvironment and replicate important disease characteristics such as distant metastatic spread...
May 25, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29880012/albumin-mass-balance-and-kinetics-in-liver-transplantation
#10
Mariam Amouzandeh, Greg Nowak, Anna Januszkiewicz, Jan Wernerman, Olav Rooyackers, Åke Norberg
BACKGROUND: In major abdominal surgery albumin is shifted from the circulation, presumably leaking into the interstitial space, contributing to a 30-40% decrease in plasma albumin concentration. During and after liver transplantation exogenous albumin is infused for volume substitution and to maintain plasma albumin concentration. Here we used liver transplantation as a model procedure for the study of albumin mass balance and kinetics during major abdominal surgery with albumin substitution...
June 7, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29879760/preclinical-efficacy-of-v4q5-ddavp-a-second-generation-vasopressin-analog-on-metastatic-spread-and-tumor-associated-angiogenesis-in-colorectal-cancer
#11
Juan Garona, Natasha T Sobol, Marina Pifano, Valeria I Segatori, Daniel E Gomez, Giselle V Ripoll, Daniel F Alonso
Purpose: Control of metastatic spread of colorectal cancer (CRC) remains as a major therapeutic challenge. [V4Q5]dDAVP is a vasopressin peptide analog with previously reported anticancer activity against carcinoma tumors. By acting as a selective agonist of AVPR2 present in endothelial and tumor cells, [V4Q5]dDAVP is able to impair tumor aggressiveness and distant spread. Our aim was to evaluate the potential therapeutic benefits of [V4Q5]dDAVP on highly aggressive CRC disease using experimental models with translational relevance...
June 1, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29875801/indications-for-liver-surgery-in-benign-tumours
#12
Margot Fodor, Florian Primavesi, Eva Braunwarth, Benno Cardini, Thomas Resch, Reto Bale, Daniel Putzer, Benjamin Henninger, Rupert Oberhuber, Manuel Maglione, Christian Margreiter, Stefan Schneeberger, Dietmar Öfner, Stefan Stättner
Background: Management of benign liver tumours (BLT) is still object of discussion. Uncertainty still exists about patient selection, details of management, indications for surgical intervention and potential surgery-related complications. The up-to-date strategies for management of the most common benign solid tumours are recapitulated in this article. In addition, recommendations concerning practical issues are presented. Methods: Available data from peer-reviewed publications associated with the major controversies concerning treatment strategies of solid BLT were selected through a PubMed literature search...
2018: European Surgery: ACA: Acta Chirurgica Austriaca
https://www.readbyqxmd.com/read/29875798/surgical-techniques-and-strategies-for-the-treatment-of-primary-liver-tumours-hepatocellular-and-cholangiocellular-carcinoma
#13
Eva Braunwarth, Stefan Stättner, Margot Fodor, Benno Cardini, Thomas Resch, Rupert Oberhuber, Daniel Putzer, Reto Bale, Manuel Maglione, Christian Margreiter, Stefan Schneeberger, Dietmar Öfner, Florian Primavesi
Background: Owing to remarkable improvements of surgical techniques and associated specialities, liver surgery has become the standard of care for hepatocellular carcinoma and cholangiocarcinoma. Although applied with much greater safety, hepatic resections for primary liver tumours remain challenging and need to be integrated in a complex multidisciplinary treatment approach. Methods: This literature review gives an update on the recent developments regarding basics of open and laparoscopic liver surgery and surgical strategies for primary liver tumours...
2018: European Surgery: ACA: Acta Chirurgica Austriaca
https://www.readbyqxmd.com/read/29858538/benign-prostatic-hyperplasia-and-intraprostatic-inflammation-are-associated-with-liver-inflammation-it-s-time-for-prevention
#14
S Privitera, G I Russo, S La Vignera, R A Condorelli, A E Calogero, F Cantiello, R Damiano, V Favilla, S Cimino, G Morgia
Some evidences have supported the link between benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) and inflammation. In this study, we aimed to evaluate the association between prostatic inflammation (PI) and non-alcoholic steatohepatitis (NASH) evaluated by a non-invasive scores in a cohort of patients affected by BPH/LUTS. Between January 2012 and January 2016, we conducted a prospective study in a single academic outpatient clinic on 132 consecutive patients who underwent surgery for lower urinary tract symptoms (LUTS) due to bladder outlet obstruction (BOO)...
June 1, 2018: Andrology
https://www.readbyqxmd.com/read/29850987/the-hepatobiliary-complications-of-malnutrition-and-nutritional-support-in-adults
#15
Andrew McNeice, Ryan Scott, Gerard Patrick Rafferty, William Jonathan Cash, Graham Blake Turner
Hepatobiliary complications of hypoalimentation and parenteral nutrition (PN) are widely recognised. Hypoalimentation includes conditions such as anorexia nervosa (AN), obesity malnutrition and liver disease following bariatric surgery. Treatment of the underlying condition causing hypoalimentation can result in an improvement in liver dysfunction. Liver function test abnormalities are also commonly found in patients on PN, with the three main complications being steatosis, cholestasis and biliary system sludge/stones...
May 31, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29850295/microwave-thermal-ablation-in-an-unusual-case-of-malignant-and-locally-advanced-rare-tumor-of-pancreas-in-asa-iv-old-male-patient-and-literature-review
#16
Francesco D'Amico, Michele Finotti, Chiara Di Renzo, Alessio Pasquale, Alessandra Bertacco, Giorgio Caturegli, Gabriel E Gondolesi, Umberto Cillo
Pancreatic intraductal papillary-mucinous neoplasm is a rare primary neoplasm of unknown pathogenesis. This kind of tumor represents 0.2-2.7% of all pancreatic cancers and they may proceed to malignant lesions. In this study, we describe a case of pancreatic intraductal papillary-mucinous tumor (4.3 cm) with normal tumoral markers and nuclear atypia. We perform also a systematic review of the literature on MEDLINE and find only one relevant study that used microwave ablation for the palliative treatment of pancreatic tumor...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29843693/first-right-lobe-living-donor-hepatectomy-after-sleeve-gastrectomy
#17
Aiman Obed, Abdalla Bashir, Anwar Jarrad
BACKGROUND: Obesity presents one of the leading causes of many chronic liver disorders and injuries. Nowadays, non-alcoholic steatohepatitis (NASH) demonstrates a challenging issue for the global health system. NASH can progress to life-threatening conditions such as cirrhosis and hepatocellular or cholangio carcinoma. Currently, NASH cirrhosis is a major indication for liver transplant (LT). CASE PRESENTATION: We present the case of a 37 year-old male who has lost 74 kg after undergoing successful laparoscopic sleeve gastrectomy (SG) four years ago...
May 29, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29789277/applicability-of-a-web-based-individualized-exercise-intervention-in-patients-with-liver-disease-cystic-fibrosis-esophageal-cancer-and-psychiatric-disorders-process-evaluation-of-4-ongoing-clinical-trials
#18
Daniel Pfirrmann, Nils Haller, Yvonne Huber, Patrick Jung, Klaus Lieb, Ines Gockel, Krystyna Poplawska, Jörn Markus Schattenberg, Perikles Simon
BACKGROUND: In the primary and secondary prevention of civilization diseases, regular physical activity is recommended in international guidelines to improve disease-related symptoms, delay the progression of the disease, or to enhance postoperative outcomes. In the preoperative context, there has been a paradigm shift in favor of using preconditioning concepts before surgery. Web-based interventions seem an innovative and effective tool for delivering general information, individualized exercise recommendations, and peer support...
May 22, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29761168/outcomes-of-surgical-management-of-familial-intrahepatic-cholestasis-1-and-bile-salt-export-protein-deficiencies
#19
Laura N Bull, Ludmila Pawlikowska, Sandra Strautnieks, Irena Jankowska, Piotr Czubkowski, Jennifer L Dodge, Karan Emerick, Catherine Wanty, Sami Wali, Samra Blanchard, Florence Lacaille, Jane A Byrne, Albertien M van Eerde, Kaija-Leena Kolho, Roderick Houwen, Steven Lobritto, Vera Hupertz, Patricia McClean, Giorgina Mieli-Vergani, Etienne Sokal, Philip Rosenthal, Peter F Whitington, Joanna Pawlowska, Richard J Thompson
Progressive familial intrahepatic cholestasis (PFIC) with normal circulating gamma-glutamyl transpeptidase levels can result from mutations in the ATP8B1 gene (encoding familial intrahepatic cholestasis 1 [FIC1] deficiency) or the ABCB11 gene (bile salt export protein [BSEP] deficiency). We investigated the outcomes of partial external biliary diversion, ileal exclusion, and liver transplantation in these two conditions. We conducted a retrospective multicenter study of 42 patients with FIC1 deficiency (FIC1 patients) and 60 patients with BSEP deficiency (BSEP patients) who had undergone one or more surgical procedures (57 diversions, 6 exclusions, and 57 transplants)...
May 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29749431/expression-of-annexin-ii-and-stromal-tenascin-c-promotes-epithelial-to-mesenchymal-transition-and-correlates-with-distant-metastasis-in-pancreatic-cancer
#20
Naoko Yoneura, Shigetsugu Takano, Hideyuki Yoshitomi, Yasuyuki Nakata, Reiri Shimazaki, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Masaru Miyazaki, Masayuki Ohtsuka
The interaction between cancer cells and stromal components contributes to cancer invasion and metastasis in pancreatic ductal adenocarcinoma (PDAC). The present study investigated the role of the correlation between annexin II (ANX2) and stromal tenascin C (TNC) with the progression of PDAC. The functions of the expression ANX2 and TNC were assessed in in vitro experiments using mouse and human PDAC cells, and the clinical effect was analyzed using immunohistochemistry with surgically resected PDAC tissues...
May 2, 2018: International Journal of Molecular Medicine
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