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https://www.readbyqxmd.com/read/29433557/metastatic-uveal-melanoma-showing-durable-response-to-anti-ctla-4-and-anti-pd-1-combination-therapy-after-experiencing-progression-on-anti-pd-1-therapy-alone
#1
Muhammad Zubair Afzal, Rodwell Mabaera, Keisuke Shirai
BACKGROUND: Uveal melanoma accounts for 85% of the ocular melanomas and has an increased risk of hematogenous spread, most commonly to the liver. After curative intent therapy like surgery and radiation, fifty percent of patients present with distant metastasis. Metastatic uveal melanoma (MUM) does not harbor typically targetable mutations, e.g., BRAF as in cutaneous melanoma. As a result, there is no proven therapy for MUM. Various chemotherapy and immunotherapy regimens have been tried and only partial response (PR) is the best that has been achieved in most of the cases...
February 12, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29423737/aggressive-and-multidisciplinary-local-approach-to-iterative-recurrences-of-colorectal-liver-metastases
#2
Luca Viganò, Vittorio Pedicini, Tiziana Comito, Carlo Carnaghi, Guido Costa, Dario Poretti, Ciro Franzese, Nicola Personeni, Daniele Del Fabbro, Lorenza Rimassa, Marta Scorsetti, Armando Santoro, Luigi Solbiati, Guido Torzilli
BACKGROUND: Liver resection (LR) of colorectal metastases is associated with high recurrence risk. Aggressive local retreatment is advocated, but further recurrences may occur. Poor is known about presentation, treatment, and outcome of iterative recurrences. METHODS: A series of 323 consecutive patients undergoing first LR in the period 2004-2013 was reviewed. Patients with recurrence were included. Any local treatment (surgery, radiofrequency ablation (RFA) and stereotactic body radiation therapy (SBRT)) was analyzed...
February 8, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29409315/prognostic-impact-of-postoperative-123i-metaiodobenzylguanidine-scintigraphy-added-value-of-spect-ct-and-semiquantification-of-the-uptake-at-the-surgical-site
#3
Mathieu Gauthé, Matthieu Breton, Nina Jehanno, Cécile Cellier, Jean Michon, Sabine Sarnacki, Gudrun Schleiermacher, Myriam Wartski
BACKGROUND: The aim of this study was to assess the prognostic value of postoperative 123I-MIBG scintigraphy, including systematic SPECT/CT and semiquantification of the uptake at the surgical site, in a prospective series of NB patients. METHODS: Patients operated for neuroblastoma and who had benefited from postoperative 123I-MIBG scintigraphy were prospectively and consecutively included. Completeness of surgery was assessed on operative report. One month postoperative 123I-MIBG scintigraphy included planar acquisition and SPECT/CT...
February 5, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29398875/neuroendocrine-carcinoma-of-the-gastric-stump-a-case-report-and-literature-review
#4
Fu-Hai Ma, Li-Yan Xue, Ying-Tai Chen, Yi-Bin Xie, Yu-Xin Zhong, Quan Xu, Yan-Tao Tian
We herein report a case of neuroendocrine carcinoma of the gastric stump found 47 years after Billroth II gastric resection for a benign gastric ulcer. A 74-year-old man was referred to another hospital with melena. Endoscopic examination revealed a localized ulcerative lesion at the gastrojejunal anastomosis. The diagnosis by endoscopic biopsy was neuroendocrine carcinoma. A total gastrectomy of the remnant stomach with D2 lymphadenectomy was performed at our hospital. The lesion invaded the subserosa, and metastasis was found in two of nine the lymph nodes retrieved...
January 28, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29397633/analysis-of-patient-selection-policy-and-pattern-of-recurrence-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-colorectal-carcinomatosis
#5
Manuela Robella, Marco Vaira, Alice Borsano, Michele DE Simone
BACKGROUND: Actual cure rate and patterns of recurrence after cytoreductive surgery (CRS) associated to hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with colorectal peritoneal carcinomatosis (PC) are not yet well explored. Moreover, the selection policy to this resource-consuming treatment is still a matter of debate. METHODS: From a dataset of 400 CRS+HIPEC performed between October 1996 and December 2015, we selected 54 consecutive patients with colorectal PC...
February 1, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29397624/-retrospective-analysis-of-diagnosis-and-treatment-of-breast-cancer-in-pregnancy
#6
F W Wang, S M Fu, Y C Jin, X H Gong, H D Cheng, K J Wu
Objective: To investigate the principles of diagnosis and treatment of breast cancer during pregnancy. Methods: Clinical data of patients with breast cancer during pregnancy admitted to Obstetrics and Gynecology Hospital of Fudan University between January 2012 to July 2017 were analyzed retrospectively. A total of 17 patients were diagnosed with breast cancer in pregnancy, the median age was 32 years (range from 25 to 45 years old), pathological staging revealed 2 patient with stage 0, 1 with stage Ⅱa, 7 with stage Ⅱb, 1 with stage Ⅲa, 2 with stage Ⅲc, 4 with stage Ⅳ...
February 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29397129/dexmedetomidine-promotes-metastasis-in-rodent-models-of-breast-lung-and-colon-cancers
#7
H Lavon, P Matzner, A Benbenishty, L Sorski, E Rossene, R Haldar, E Elbaz, J P Cata, V Gottumukkala, S Ben-Eliyahu
BACKGROUND: Perioperative strategies can significantly influence long-term cancer outcomes. Dexmedetomidine, an α 2 -adrenoceptor agonist, is increasingly used perioperatively for its sedative, analgesic, anxiolytic, and sympatholytic effects. Such actions might attenuate the perioperative promotion of metastases, but other findings suggest opposite effects on primary tumour progression. We tested the effects of dexmedetomidine in clinically relevant models of dexmedetomidine use on cancer metastatic progression...
January 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29394847/-a-case-in-which-s-1-oxaliplatin-sox-trastuzumab-therapy-was-effective-for-unresectable-her2-positive-advanced-gastric-cancer-and-radical-resection-could-be-performed
#8
Hirotsugu Nagase, Kozo Noguchi, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Yoshito Tomimaru, Tomono Kawase, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Keizo Dono
The case was a 70s-year-old man. In July 2016, he was admitted to our hospital with a complaint of epigastralgia. Upper gastrointestinal endoscopy revealed type 3 advanced gastric cancer in the vestibule, directly infiltrating the pancreas and the left lobe of the liver to form an abscess, and swelling of the aortic lymph node and multiple liver metastases were observed. The cancer was diagnosed as cT4b(liver/pancreas), N2M1(H1P0CYX), cStage IV and diagnosed it as a chemotherapy policy. We initiated SOX plus trastuzumab therapy from August 2016...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394743/-a-case-of-duodenum-neuroendocrine-tumor-with-multiple-liver-metastasis-treated-with-multimodal-therapy
#9
Hirotomo Murakami, Naoki Hama, Sakae Maeda, Atsushi Miyamoto, Takuya Hamakawa, Mamoru Uemura, Masakazu Miyake, Kazuhiro Nishikawa, Hideyasu Omiya, Michihiko Miyazaki, Masataka Ikeda, Motohiro Hirao, Koji Takami, Mitsugu Sekimoto, Shoji Nakamori
The patient is a 65-year-old woman with anemia. The multiple liver tumors detected by ultrasonography, it was diagnosed as neuroendocrine tumor(NET), G2 by biopsy. There was an ulcer at the bulb of the duodenum, so we diagnosed liver metastasis of duodenum NET. Because the liver tumors spreaded to both right and left lobes, we carrying out a transcatheter arterial embolization(TAE)twice to liver metastasis, and chemotherapy by octreotide was performed. 20 months after the beginning of treatment, a 4 cm tumor was remained in the left lobe but others were not detected by computed tomography, so we performed cytoreductive surgery...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394625/-a-case-of-metastasis-to-the-base-of-the-skull-after-rectal-cancer-operation-with-symptom-management-via-radiotherapy
#10
Megumi Sasaki, Toshiaki Ishikawa, Shinichi Yamauchi, Fukuichiro Orita, Tomiyuki Miura, Michiyo Tokura, Marie Hanaoka, Akifumi Kikuchi, Megumi Ishiguro, Masamichi Yasuno, Hiroyuki Uetake
In 2009, A 67-year-old woman underwent high anterior resection for rectal cancer(RS, type 2, pT3, pN1, cM0, pStage III a). U FT/LV was administered for 6 months as adjuvant chemotherapy after the operation. Because peritoneum dissemination and pelvic lymph node metastasis developed 9 months after the operation, CapeOX plus Bmab therapy was started, and we monitored the cancer partial response for the next 6 years. Six years and 9 months after the operation, we detected metastasis to the sacrum; thus, radiotherapy was started...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394602/-a-case-of-her2-positive-unresectable-gastric-cancer-with-multiple-lymph-node-and-liver-metastases-controlled-effectively-by-combination-chemotherapy-with-capecitabine-oxaliplatin-and-trastuzumab
#11
Nariatsu Sato, Akira Nakayama, Yuki Takai, Toru Kamata
A 77-year-old woman was diagnosed with HER2-positive unresectable gastric cancer with multiple lymph node and liver metastases(cT3-4, cN3, cM1[HEP, LYM], cStage IV ). Four courses of combination chemotherapy with capecitabine, oxaliplatin, and trastuzumab(XELOX plus Tras)were administered. Though all lesions showed a complete or partial response, anorexia and body weight loss appeared because of the stenosis in the primary gastric lesion. After another course, these symptoms became worse and she underwent laparoscopic gastrojejunostomy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394599/-a-case-of-granulocyte-colony-stimulating-factor-producing-breast-cancer-that-caused-rapid-progression
#12
Tatsuya Inoue, Junya Minohata, Masaki Tanaka, Toshimi Tabuchi, Haruki Morimoto, Yoshiaki Tatsumi, Masanori Takenaga, Masato Fukuoka, Tetsuya Sakai, Shiro Tachibana, Takashi Ito, Takashi Nishigami
We report a case of granulocyte-colony stimulating factor(G-CSF)producing breast cancer in a 54-year-old woman. Eight months after surgery, multiple liver and pulmonary metastases appeared. They progressed rapidly in 2 weeks and she had a high fever of 38 degrees. Serum G-CSF was high, and positive cells were found by immunostaining of the primary tumor. Chemotherapy was initially successful but she died 4 months after relapse.
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394550/-a-patient-with-basaloid-carcinoma-of-the-esophagus-removed-surgically-after-pre-operative-chemotherapy-who-developed-ttp-during-post-operative-chemotherapy
#13
Akemi Watanabe, Hiroyuki Fukunari, Yousuke Kawai, Makoto Aoki, Satoshi Saito, Yuya Umebayashi, Kenji Shitara, Tetsuji Hayashi, Gen Watanabe, Hiroshi Ajioka
A 63-year-old man presented with the chief complaint of an unpleasant feeling in the chest after a meal.Esophagogastroduodenoscopy revealed interminglement of ulcer infiltration type lesions and protruding lesions in the lower esophagus.A large type 1 protruding lesion was located mainly in the esophagogastric junction(EGJ)and it progressed towards the stomach.A hypertrophic and protruding lesion on the lower esophageal wall and a 6 cm tumor in the major axis of the fornix were observed on thoracic and abdominal CT, and an endocrine cell carcinoma or basaloid carcinoma were suggested after biopsy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29390323/liver-transplantation-for-decompensated-liver-cirrhosis-caused-by-progressive-familial-intrahepatic-cholestasis-type-3-a-case-report
#14
Deng Xiang, Jiannan He, Hongmei Wang, Fangfang Xiong, Hao Cheng, Junhua Ai, Renfeng Shan, Renhua Wan, Lunli Zhang, Jun Shi
RATIONALE: Progressive familial intrahepatic cholestasis (PFIC) type 3, characterized by high gamma glutamyl transferase (GGT), is an autosomal recessive genetic disease. It often occurs in patients' first years of age. However, high GGT type PFIC is still rare. PATIENT CONCERNS: The present study reports a case of liver transplantation for decompensated liver cirrhosis caused by PFIC type 3. An 18-year-old male presented with a history of abdominal distension and jaundice for 2 months...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29380091/the-gastric-carcinosarcoma-with-severe-venous-invasion-a-case-report
#15
Tomoaki Bekki, Nobuaki Fujikuni, Kazuaki Tanabe, Shuji Yonehara, Hironobu Amano, Toshio Noriyuki, Masahiro Nakahara
BACKGROUND: Gastric carcinosarcoma with severe venous invasion is extremely rare, and to the best of our knowledge, this is the first reported case. CASE PRESENTATION: A 79-year-old man visited the Onomichi General Hospital following abnormal upper gastrointestinal series findings. Laboratory data demonstrated no anemia, and the serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels were not elevated. Endoscopy identified a Borrmann type III lesion in the cardiac end of the stomach...
January 30, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29377874/successful-sequential-liver-and-haematopoietic-stem-cell-transplantation-in-a-child-with-cd40-ligand-deficiency-and-cryptosporidium-induced-liver-cirrhosis
#16
Paola Quarello, Francesco Tandoi, Francesca Carraro, Elena Vassallo, Michele Pinon, Renato Romagnoli, Ezio David, Dominic Dell Olio, Mauro Salizzoni, Franca Fagioli, Pier Luigi Calvo
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is curative in patients with primary immunodeficiencies. However, pre-HSCT conditioning entails unacceptably high risks if the liver is compromised. The presence of a recurrent opportunistic infection affecting the biliary tree and determining liver cirrhosis with portal hypertension posed particular decisional difficulties in a seven-year-old child with X-linked CD40-ligand deficiency. We aim at adding to the scanty experience available on such rare cases, as successful management with sequential liver transplantation (LT) and HSCT has been reported in detail only in one young adult to date...
January 26, 2018: Transplantation
https://www.readbyqxmd.com/read/29362840/role-of-interventional-radiology-in-managing-pediatric-liver-tumors-part-1-endovascular-interventions
#17
REVIEW
Matthew P Lungren, Alexander J Towbin, Derek J Roebuck, Eric J Monroe, Anne E Gill, Avnesh Thakor, Richard B Towbin, Anne Marie Cahill, C Matthew Hawkins
Primary liver malignancies are rare in children. Hepatoblastoma and hepatocellular carcinoma (HCC) together represent the overwhelming majority of cases. Overall survival of hepatoblastoma approaches 80% with multimodal treatment approaches that include chemotherapy, surgery and transplantation. However, there remains a subset of children with hepatoblastoma in whom resection or transplantation is not possible. The 5-year survival for children diagnosed with HCC is less than 30% and remains a significant therapeutic challenge...
January 23, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29361048/role-of-the-cytochrome-p-450-epoxyeicosatrienoic-acids-pathway-in-the-pathogenesis-of-renal-dysfunction-in-cirrhosis
#18
Michael M Yeboah, Md Abdul Hye Khan, Marla A Chesnik, Melissa Skibba, Lauren L Kolb, John D Imig
Background: Hepatorenal syndrome (HRS) is a life-threatening complication of advanced liver cirrhosis that is characterized by hemodynamic alterations in the kidney and other vascular beds. Cytochrome P(CYP)-450 enzymes metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acids. These eicosanoids regulate blood pressure, vascular tone and renal tubular sodium transport under both physiological and pathophysiological states. Methods: Experiments were performed to investigate the role of the CYP system in the pathogenesis of renal dysfunction during cirrhosis...
January 19, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29337443/-update-in-surgical-oncology
#19
Daniel Clerc, Didier Roulin, Nicolas Demartines, Emmanuel Melloul
In 2017, data from large multicentre randomized controlled trials assessed the safety of minimally invasive techniques for liver or esophagus resection with similar oncologic outcome compared to open approach. Patients also benefit from progress in medical oncology in particular with the development of new targeted therapies, offering surgery to patients with initially non-resectable disease. The increase in complete tumor response after neoadjuvant treatment allows more conservative approaches, like organ preserving surgery for rectal cancer...
January 10, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29334903/a-rare-case-of-pericarditis-and-pleural-empyema-secondary-to-transdiaphragmatic-extension-of-pyogenic-liver-abscess
#20
Eunae Cho, Sang Woo Park, Chung Hwan Jun, Sang Soo Shin, Eun Kyu Park, Kyo Seon Lee, Seon Young Park, Chang Hwan Park, Hyun Soo Kim, Sung Kyu Choi, Jong Sun Rew
BACKGROUND: Transdiaphragmatic extension of pyogenic liver abscess is the rarest cause of pericarditis and pleural empyema. It is a rapidly progressive and highly lethal infection with mortality rates reaching 100% if left untreated. However, the transmission route, treatment methods and prognosis have not been well studied. CASE PRESENTATION: A 65-year-old male patient presented with a fever, dyspnea, and right upper quadrant abdominal pain. Computed tomography of the chest and abdomen showed huge liver abscess without full liquefaction in the left lobe, large amount of left pleural effusion, and mild pericardial effusion, and the patient was treated with parenteral antibiotics and pigtail insertion at the left pleura...
January 15, 2018: BMC Infectious Diseases
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