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https://www.readbyqxmd.com/read/28734992/endoscopic-muscle-biopsy-emb-of-the-duodenum-and-rectum-a-pilot-survival-study-in-a-porcine-model-to-detect-myenteric-neurons
#1
E Rajan, B Al-Bawardy, C J Gostout, L M Wong Kee Song, J L Deters, M A Knipschield, C E Bernard, G Farrugia
BACKGROUND AND AIMS: Small bowel and colorectal muscle biopsies require a surgical approach. Advancing our understanding of the pathophysiology of motility disorders, such as functional bowel disorders, intestinal pseudo-obstruction and slow transit constipation, is hindered by our inability to non-invasively obtain muscularis propria (MP) for evaluation of multiple cell types, including myenteric neurons. The aims of this study were to determine (1) technical feasibility, reproducibility and safety of performing duodenal endoscopic muscle biopsy (dEMB) and rectal endoscopic muscle biopsy (rEMB) using a clip-assist technique; and (2) presence of myenteric neurons in tissue samples...
July 19, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28734991/endoscopic-full-thickness-resection-using-suture-loop-needle-t-tag-tissue-anchors-in-the-porcine-stomach-with-video
#2
Akira Dobashi, Elizabeth Rajan, Mary A Knipschield, Christopher J Gostout
BACKGROUND AND AIMS: Endoscopic full-thickness resection (EFTR) is still challenging and a reliable technique is desirable. The aim of this study was to evaluate the feasibility of controlled EFTR using a pseudopolyp made from suture loop needle-T-tag (SLNT) tissue anchors in ex vivo porcine stomachs. METHODS: Five pig stomachs were used. Two concentric circumferential border mucosal incisions were made to facilitate isolating a target lesion for full-thickness excision and pseudopolyp formation...
July 19, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28734832/superficial-esophageal-mucosal-afferent-nerves-may-contribute-to-reflux-hypersensitivity-in-non-erosive-reflux-disease
#3
P Woodland, J L Ooi, F Grassi, K Nikaki, C Lee, J A Evans, N Koukias, C Triantos, S A McDonald, M Peiris, R Aktar, L A Blackshaw, D Sifrim
BACKGROUND & AIMS: Little is known about the causes of heartburn in patients with gastro-esophageal reflux disease (GERD). Visible epithelial damage is seldom associated with symptom severity, evidenced by the significant symptom burden in patients with non-erosive reflux disease (NERD) compared to patients with erosive reflux disease (ERD) or Barrett's esophagus (BE). We studied the distribution of mucosal nerve fibers in patients with NERD, ERD, and BE, and compared the results with those of healthy subjects...
July 19, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28733736/effects-of-steroid-use-for-stenosis-prevention-after-wide-endoscopic-submucosal-dissection-for-gastric-neoplasm
#4
Yoshihiro Kishida, Naomi Kakushima, Kohei Takizawa, Masaki Tanaka, Noboru Kawata, Masao Yoshida, Sayo Ito, Kenichiro Imai, Hirotoshi Ishiwatari, Kinichi Hotta, Hiroyuki Matsubayashi, Hiroyuki Ono
BACKGROUND: Stenosis is a troublesome complication after wide endoscopic submucosal dissection (ESD). As steroids are known to prevent post-ESD esophageal stenosis, this study aimed to clarify the gastric effects. METHODS: This was a retrospective single-institution study. Between September 2002 and June 2015, 132 patients with a post-ESD mucosal defect exceeding three-fourths of the circumference were identified. Among them, 107 patients who did not undergo additional surgery for non-curative resection were reviewed...
July 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28732392/systematic-assessment-with-i-scan-magnification-endoscopy-and-acetic-acid-improves-dysplasia-detection-in-patients-with-barrett-s-esophagus
#5
Gideon Lipman, Raf Bisschops, Vinay Sehgal, Jacobo Ortiz-Fernández-Sordo, Rami Sweis, Jose M Esteban, Rifat Hamoudi, Matthew R Banks, Krish Ragunath, Laurence B Lovat, Rehan J Haidry
Background and study aims Enhanced endoscopic imaging with chromoendoscopy may improve dysplasia recognition in patients undergoing assessment of Barrett's esophagus (BE). This may reduce the need for random biopsies to detect more dysplasia. The aim of this study was to assess the effect of magnification endoscopy with I-SCAN (Pentax, Tokyo, Japan) and acetic acid (ACA) on dysplasia detection in BE using a novel mucosal and vascular classification system. Methods BE segments and suspicious lesions were recorded with high definition white-light and magnification endoscopy enhanced using all I-SCAN modes in combination...
July 21, 2017: Endoscopy
https://www.readbyqxmd.com/read/28732002/-gastrointestinal-stromal-tumor-in-young-pregnant-woman-case-report
#6
Walker Del Cid Jove Oblitas, Miguel Joseph Abril Barreda
Female patient, 28 years old, with a gestation of 14 weeks, natural and from Ilo-Moquegua. Came with a time of disease 4 days with hematemesis, melena, epigastric pain and syncope. Background of colonic resection for peritonitis due to trauma 20 years ago; upper gastrointestinal bleeding three years ago; paternal grandparents died of gastric cancer; chronic gastritis diagnosed from 19 year old. In laboratory studies hemoglobin of 9.2. In the upper gastrointestinal endoscopy was found absence of active upper gastrointestinal bleeding, a large tumor in proximal body toward greater curvature and posterior wall, 8 cm in diameter approximately, lobed appearance, with most of the mucosal surface unscathed is evidence, areas of ulceration of 2-3 mm covered with fibrin (biopsies taken), hard consistency, tent sign (positive) and cushionsign (negative)...
April 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28731572/endoscopic-surgical-technique-for-benign-fibrotic-strictures-of-the-upper-esophageal-sphincter
#7
Shun-Ichi Chitose, Kiminori Sato, Mioko Fukahori, Sachiyo Hamakawa, Akari Koga, Shintaro Sueyoshi, Hirohito Umeno
A 43-year-old man with complaints of increased difficulty of swallowing and weight loss underwent videofluorographic examination of swallowing, which revealed severely reduced cricopharyngeal opening. Endoscopic cricopharyngeal myotomy was performed using a modified technique (mECPM). A benign fibrotic stricture of the upper esophageal sphincter (UES) was identified under visualization of a distending operating laryngoscope. A vertical midline incision in the strictured mucosa and submucosal resection of the cricopharyngeal muscle were performed using a CO2 laser...
July 21, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28731502/histologic-scoring-indices-for-evaluation-of-disease-activity-in-crohn-s-disease
#8
REVIEW
Gregor Novak, Claire E Parker, Rish K Pai, John K MacDonald, Brian G Feagan, William J Sandborn, Geert D'Haens, Vipul Jairath, Reena Khanna
BACKGROUND: Histologic assessment of mucosal disease activity has been increasingly used in clinical trials of treatment for Crohn's disease. However, the operating properties of the currently existing histologic scoring indices remain unclear. OBJECTIVES: A systematic review was undertaken to evaluate the development and operating characteristics of available histologic disease activity indices in Crohn's disease. SEARCH METHODS: Electronic searches of MEDLINE, EMBASE, PubMed, and the Cochrane Library (CENTRAL) databases from inception to 20 July 2016 were supplemented by manual reviews of bibliographies and abstracts submitted to major gastroenterology meetings (Digestive Disease Week, United European Gastroenterology Week, European Crohn's and Colitis Organisation)...
July 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28727260/gastric-per-oral-endoscopic-myotomy-g-poem-for-pylorospasm-case-report-and-literature-review
#9
Wen Wen Zheng, Ming Ming Zhang, Yan Zhang, Zhen Li, Xiu Li Zuo, Xue Feng Lu, Yan Qing Li
Gastric per oral endoscopic myotomy is a novel endoscopic technique, using mucosal incision and submucosal tunneling, to access and surgically divide the pyloric ring. It has been reported as a technically feasible procedure and minimally invasive therapy for refractory gastroparesis. We performed this procedure in a 63-year-old male patient with postoperative pylorospasm, with clinical success. Pylorospasm is one of pathophysiologic mechanisms underlying gastroparesis. As a subgroup of gastroparesis, pylorospasm should be identified to be an appropriate indication for gastric per oral endoscopic myotomy...
July 20, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28726517/robot-assisted-tumor-resection-devices
#10
Yutaka Saito, Kazuki Sumiyama, Philip Wai Yan
In Japan, colorectal endoscopic submucosal dissection (ESD) is being conducted safely and effectively as shown by the increased number of the cases, however, it is still regarded as a complicated and challenging procedure. Therefore, piecemeal endoscopic mucosal resection (p-EMR) is still regarded as an appropriate treatment, rather than ESD for large colorectal tumors, especially in Western countries. Areas covered: There are several factors that are responsible for colorectal ESD difficulty. Firstly, there is no adequate traction or counter-traction in colorectal ESD...
July 20, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28724307/per-oral-endoscopic-myotomy-poem-a-new-endoscopic-treatment-for-achalasia
#11
Pablo Miranda García, Fernando Casals Seoane, Jean-Michel Gonzalez, Marc Barthet, Cecilio Santander Vaquero
BACKGROUND/AIMS: Per-oral endoscopic myotomy (POEM) is a new minimally invasive technique to treat achalasia. METHODS: We performed a review of the literature of POEM with a special focus on technical details and the results obtained with this technique in patients with achalasia and other esophageal motility disorders. RESULTS: Thousands of POEM procedures have been performed worldwide since its introduction in 2008. The procedure is based on the creation of a mucosal entry point in the proximal esophagus to reach the cardia through a submucosal tunnel and then perform a myotomy of the muscular layers of the cardia, esophagogastric junction and distal esophagus, as performed in a Heller myotomy...
July 14, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28723856/fecal-matrix-metalloprotease-9-and-lipocalin-2-as-biomarkers-in-detecting-endoscopic-activity-in-patients-with-inflammatory-bowel-diseases
#12
Anthony Buisson, Emilie Vazeille, Régine Minet-Quinard, Marion Goutte, Damien Bouvier, Félix Goutorbe, Bruno Pereira, Nicolas Barnich, Gilles Bommelaer
BACKGROUND: Fecal biomarkers are emerging tools in the assessment of mucosal healing in inflammatory bowel diseases (IBD). GOALS: We aimed to evaluate the accuracy of fecal matrix metalloprotease-9 (MMP-9) and fecal lipocalin-2 (LCN-2) compared with calprotectin in detecting endoscopic activity in IBD STUDY:: Overall, 86 IBD adults underwent colonoscopy consecutively and prospectively, with Crohn's disease Endoscopic Index of Severity (CDEIS) in Crohn's disease (CD) patients or Mayo endoscopic subscore calculation for ulcerative colitis (UC) patients, and stool collection...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28723285/case-244-systemic-amyloidosis-a-complication-of-waldenstr%C3%A3-m-macroglobulinemia
#13
Maja Hrabak-Paar, Marko Kralik
History A 68-year-old man was admitted to the hospital for work-up because of generalized fatigue, anorexia, chronic diarrhea, and weight loss. Laboratory work-up revealed an erythrocyte sedimentation rate of 58 mm/h (reference range, 3-23 mm/h), a hemoglobin level of 14.1 g/dL (reference range, 13.8-17.5 g/dL), a leukocyte count of 8.1 × 10(9)/L (reference range, [3.4-9.7] × 10(9)/L), a platelet count of 223 × 10(9)/L (reference range, [158-424] × 10(9)/L), an alkaline phosphatase level of 85 U/L (1.42 μkat/L) (normal level, <142 U/L [2...
August 2017: Radiology
https://www.readbyqxmd.com/read/28722090/-evaluation-of-a-new-closure-technique-of-large-defects-after-endoscopic-full-thickness-resection
#14
Xiao Liu, Lizhou Dou, Yong Liu, Shun He, Yueming Zhang, Xinying Yu, Yan Ke, Xudong Liu, Ruigang Wang, Guiqi Wang
OBJECTIVE: To investigate the security and efficacy of a new endoscopic closure method of large defects after endoscopic full-thickness resection (EFTR) double purse-string suture using two endoloops and metallic clips via single-channel endoscopy. METHODS: Clinical data of 23 cases with submucosal tumors (SMT) who received endoscopic resection from June 2015 to July 2016 in our National Cancer Center were collected. For gastric and esophageal SMTs or the mucosa layer injured during submucosal tunneling endoscopic resection (STER), double purse-string suture was conducted after EFTR...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28721978/noninvasive-biomarkers-as-surrogate-predictors-of-clinical-and-endoscopic-remission-after-infliximab-induction-in-patients-with-refractory-ulcerative-colitis
#15
Elham A Hassan, Haidi K Ramadan, Ali A Ismael, Khaled F Mohamed, Madiha M El-Attar, Ihab Alhelali
BACKGROUND/AIMS: Treatment of refractory ulcerative colitis (UC) is a clinical challenge, and after biological therapy, monitoring clinical and endoscopic responses is fundamental. We aimed to investigate and compare the predictive power of different noninvasive parameters for clinical remission and mucosal healing after infliximab induction therapy in refractory UC patients. PATIENTS AND METHODS: Serum and fecal biomarkers, including hemoglobin, white blood cells, erythrocyte sedimentation rate, C-reactive protein (CRP), and fecal calprotectin (FC), and colonoscopy were assessed in 44 patients with refractory UC before and after (week 12) infliximab induction...
July 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28720474/nitrous-oxide-cryotherapy-for-treatment-of-esophageal-squamous-cell-neoplasia-initial-multicenter-international-experience-with-a-novel-portable-cryoballoon-ablation-system-with-video
#16
Marcia Irene Canto, Julian Abrams, Hannah Kunzli, Bas Weusten, Yoshihiro Komatsu, Blair Jobe, Charles J Lightdale
BACKGROUND AND AIMS: Early esophageal squamous cell neoplasia (ESCN) can be successfully treated by endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or radiofrequency ablation (RFA). A new portable, battery-powered cryotherapy system using nitrous oxide (cryoballoon focal ablation system (CbFAS) has been used for Barrett's esophagus. It consists of a small hand-held device containing liquid nitrous oxide, which converts to gas within a low-pressure-compliant through-the-scope balloon and freezes targeted mucosa in contact with the balloon...
July 15, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28719593/long-term-treatment-of-eosinophilic-esophagitis-with-swallowed-topical-corticosteroids-development-and-evaluation-of-a-therapeutic-concept
#17
Thomas Greuter, Christian Bussmann, Ekaterina Safroneeva, Alain M Schoepfer, Luc Biedermann, Stephan R Vavricka, Alex Straumann
OBJECTIVES: Swallowed topical corticosteroids (STCs) are efficacious in inducing and presumably maintaining remission in patients with active eosinophilic esophagitis (EoE). Hitherto, it has not been evaluated whether long-lasting remission can be achieved, and whether treatment can be stopped once patients have achieved this remission. METHODS: Since 2007, EoE patients included into a large database at the Swiss EoE Clinics were put on STCs as induction/maintenance therapy...
July 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28717578/in-vivo-analysis-of-mucosal-lipids-reveals-histological-disease-activity-in-ulcerative-colitis-using-endoscope-coupled-raman-spectroscopy
#18
Hao Ding, Andrew W Dupont, Shashideep Singhal, Larry D Scott, Sushovan Guha, Mamoun Younes, Xiaohong Bi
The goal of this study is to evaluate endoscopic Raman spectroscopy as a noninvasive technique to determine histological inflammatory status of colitis. Colon mucosal composition was investigated in vivo from patients with ulcerative colitis (UC) and from age- and body mass index (BMI) matched controls using endoscope-coupled Raman spectroscopy. The results were co-registered with histological assessment of inflammatory status at the same locations. Substantial decreases (50-60%) in the content of phosphotidylcholines (PCs) and total lipids were observed in inflamed colon tissue (histology grade 1, 2 and 3) compared to those from the quiescent (histology grade 0) and from the controls...
July 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28717210/linked-colour-imaging-benefits-the-endoscopic-diagnosis-of-distal-gastric-diseases
#19
Xiaotian Sun, Yiliang Bi, Tenghui Dong, Min Min, Wei Shen, Yang Xu, Yan Liu
Gastric diseases are common in China, and gastroduodenoscopy could provide accurate diagnoses. Our previous study verified that linked colour imaging (LCI) can improve endoscopic diagnostic accuracy. This study aimed for the first time to establish an LCI-based endoscopic model called colour-microstructure-vessel (CMV) criteria and validated its clinical feasibility for detecting distal gastric diseases manifested as red mucosal lesions under endoscopy in a cohort of 62 patients. Colour features were extracted from the endoscopic images and categorized into 3 types...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716173/central-compartment-atopic-disease
#20
John M DelGaudio, Patricia A Loftus, Aneeza W Hamizan, Richard J Harvey, Sarah K Wise
BACKGROUND: Isolated polypoid changes of the middle turbinate were recently reported as having a high association with inhalant allergy. A more advanced manifestation of this association may present as polypoid changes of the entire central sinonasal compartment (i.e., the middle and superior turbinates, and the posterosuperior nasal septum), while the lateral sinus mucosa remains relatively normal. OBJECTIVE: To introduce and describe this newly recognized variant of chronic rhinosinusitis (CRS), termed central compartment atopic disease (CCAD)...
July 1, 2017: American Journal of Rhinology & Allergy
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