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endoscopic mucosal

N D Cosgrove, D K Mullady
Endoscopy has an important role in the pre- and post-treatment staging of esophageal cancer. Complete pathologic response following neoadjuvant chemoradiation therapy occurs in approximately 25% of patients. However, the ability to accurately detect this preoperatively with currently available endoscopic modalities is limited such that the default pathway is for fit patients to proceed with surgical resection. This article discusses the available endoscopic modalities (primarily Esophagogastroduodenoscopy [EGD] with mucosal biopsies and endoscopic ultrasonography with or without fine needle aspiration) used for post-treatment staging of esophageal cancer...
June 19, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
A Koivusalo, J Suominen, R Rintala, M Pakarinen
We analyzed retrospectively the outcomes in long gap Gross type C esophageal atresia. We hypothesized that outcomes in type C (long gap) atresia differ from type C (normal gap) and be similar with outcomes in Gross type A and B esophageal atresia. Location of the distal tracheoesophageal fistula (TEF) at the carina was chosen as the hallmark of type C atresia (long gap). We compared the type of esophageal repair, major reoperations for anastomotic complications and gastroesophageal reflux, and long-term mucosal changes between type C (normal gap), type C (long gap), and type A/B...
June 19, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Marie E Robert, Sheila E Crowe, Lawrence Burgart, Rhonda K Yantiss, Benjamin Lebwohl, Joel K Greenson, Stefano Guandalini, Joseph A Murray
Small intestinal biopsy interpretation has been the cornerstone for the diagnosis of celiac disease for over 50 years. Despite the existence of sensitive and specific serological tests, duodenal mucosal biopsies continue to be obtained in the vast majority of patients in whom a diagnosis of celiac disease is being considered. The accurate evaluation of these biopsies requires coordination and information sharing between the gastroenterologist, laboratory, and pathologist in order to optimize tissue sampling, preparation and interpretation...
June 19, 2018: American Journal of Surgical Pathology
Kenichi Goda, Junko Fujisaki, Ryu Ishihara, Manabu Takeuchi, Akiko Takahashi, Yasuhiro Takaki, Dai Hirasawa, Kumiko Momma, Yuji Amano, Kazuyoshi Yagi, Hiroto Furuhashi, Tomoki Shimizu, Takashi Kanesaka, Satoru Hashimoto, Yoichiro Ono, Taku Yamagata, Junko Fujiwara, Takane Azumi, Masako Nishikawa, Gen Watanabe, Yasuo Ohkura, Tsuneo Oyama
AIM AND METHODS: The Japan Esophageal Society created a working committee group consisting of 11 expert endoscopists and 2 pathologists with expertise in Barrett's esophagus (BE) and esophageal adenocarcinoma. The group developed a consensus-based classification for the diagnosis of superficial BE-related neoplasms using magnifying endoscopy. RESULTS: The classification has three characteristics: simplified, an easily understood classification by incorporating the diagnostic criteria for the early gastric cancer, including the white zone and demarcation line, and the presence of a modified flat pattern corresponding to non-dysplastic histology by adding novel diagnostic criteria...
June 19, 2018: Esophagus: Official Journal of the Japan Esophageal Society
Wolfgang Stremmel, Simone Staffer, Nicole Stuhrmann, Hongying Gan-Schreier, Annika Gauss, Nina Burger, Daniel Hornuss
Background: Attack by commensal microbiota is one component of induction of inflammatory episodes in ulcerative colitis (UC). In UC, the mucus layer is intrinsically devoid of phosphatidylcholine (PC) resulting in low hydrophobicity which facilitates bacterial invasion. Colonic ectophospholipase-carrying bacterial strains are likely candidates to further thinning the PC mucus barrier and to precipitate inflammatory episodes. Objective: To evaluate the effect of phospholipase A2 (PLA2 ) inhibitors on inflammation in a genetic UC mouse model...
March 2018: Inflammatory Intestinal Diseases
Jaime P Rodrigues, Rolando Pinho, Mafalda Sousa, João Carlos Silva, Catarina Gomes, João Carvalho
No abstract text is available yet for this article.
June 19, 2018: Endoscopy
Peter Bossuyt, Filip Baert, Francois D'Heygere, Antoine Nakad, Catherine Reenaers, Fernand Fontaine, Denis Franchimont, Olivier Dewit, Philippe Van Hootegem, Stijn Vanden Branden, Guy Lambrecht, Marc Ferrante
Background: Golimumab (GOL) is registered for moderate to severely active ulcerative colitis (UC). Data on the use of GOL in daily clinical practice are limited. Currently, it is unclear which factors are predictive of a favorable outcome. The goals of this study were to evaluate the mid-term outcome of GOL (week 26) in patients with moderate to severe UC and to determine predictors of favorable outcome. Methods: Patients included in the SMART study (NCT02155335) were evaluated for their mid-term outcome...
June 15, 2018: Inflammatory Bowel Diseases
Qiang Zhang, Xiang Yao, Zhen Wang
No abstract text is available yet for this article.
April 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Mohit Girotra, Shai Friedland
No abstract text is available yet for this article.
April 2018: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Sakolwan Suchartlikitwong, Pakpoom Tantrachoti, Thammasak Mingbunjerdsuk, Passisd Laoveeravat, Ariwan Rakvit
Light-chain amyloidosis is caused by deposition of immunoglobulin light chains within multiple organs, including the gastrointestinal (GI) tract. Gastrointestinal hemorrhage is a less frequent presentation. Endoscopic findings are nonspecific, and bleeding mucosal polyps are rare. We report a 59-year-old Hispanic woman with a history of gastric polyps who presented with recurrent GI hemorrhage from mucosal polyps. She had periorbital purpura and macroglossia. Biopsy of the gastric polyp confirmed amyloid deposition...
2018: ACG Case Reports Journal
Rinzaburo Matsuura, Osamu Watanabe, Masanao Nakamura, Takeshi Yamamura, Masanobu Matsushita, Hiroki Suhara, Kazuhiro Furukawa, Takuya Ishikawa, Kohei Funasaka, Eizaburo Ohno, Hiroki Kawashima, Ryoji Miyahara, Yoshiki Hirooka, Hidemi Goto
Fecal calprotectin (FC) has drawn attention as a biomarker in the evaluation of Crohn's disease (CD). However, few reports have provided a detailed examination of the relationship between small-bowel CD lesions and FC levels. The present study aimed to examine the entire small bowel using double-balloon endoscopy (DBE) and to determine the relationship between the endoscopic activity in small-bowel CD and FC levels. Twenty small-bowel CD patients, who underwent DBE, were prospectively enrolled. Endoscopic evaluation was based on the simple endoscopic score for CD, with the small bowel divided into four regions...
May 2018: Nagoya Journal of Medical Science
Marcus Vinicius Candido, Pernilla Syrjä, Susanne Kilpinen, Thomas Spillmann
BACKGROUND: Gastric carcinoma (GC) is a rather rare pathological finding in dogs, with the exception of some breeds which seem predisposed. The etiopathogenesis is largely unknown in dogs, whereas in humans GC often develops from gastric mucosal metaplasia and dysplasia. This study investigates whether dogs of certain breeds are more often subject to gastroduodenoscopy (GDS), and diagnosed with GC, mucosal metaplasia or dysplasia. A retrospective clinical database search was performed at the Veterinary Teaching Hospital at the University of Helsinki, Finland...
June 18, 2018: Acta Veterinaria Scandinavica
Dingguo Zhang, Qiuling Lin, Ruiyue Shi, Lisheng Wang, Jun Yao, Yanhui Tian
BACKGROUND:  This study aimed to evaluate the clinical efficacy, safety, and feasibility of performing endoscopic submucosal resection with a ligation device (ESMR-L) after apical mucosal incision (AMI) for the treatment of gastric subepithelial tumors originating from the muscularis propria (SET-MPs). METHODS:  14 patients with gastric SET-MPs were treated by ESMR-L with AMI between December 2016 and May 2017. The complete resection rate, operation duration, and postoperative complications were collected...
June 18, 2018: Endoscopy
Takahito Sugase, Tomoki Makino, Makoto Yamasaki, Koji Tanaka, Tadayoshi Hashimoto, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Masayuki Mano, Eiichi Morii, Masaki Mori, Yuichiro Doki
INTRODUCTION: We aimed to analyze the clinical and histological effects of chemotherapy in superficial esophageal squamous cell carcinoma (SESCC). METHODS: We analyzed tumor samples from five patients with cT1bN1M0 who underwent subtotal esophagectomy following two courses of a new triplet chemotherapy regimen including docetaxel, cisplatin, and 5-fluorouracil (DCF). To assess the histological effects of chemotherapy, resected specimens were analyzed by macroscopic examination, hematoxylin & eosin (HE) staining, immunohistochemical (IHC) staining (p53, Ki-67 and cytokeratin) and periodic acid-Schiff (PAS) staining...
June 16, 2018: Esophagus: Official Journal of the Japan Esophageal Society
Douglas K Rex, Evelien Dekker
We review our approach to resection of colorectal polyps <20 mm in size. Careful inspection of all lesions is appropriate to assess the type of lesion (adenoma vs serrated) and evaluate the risk of cancer, which is highly associated with lesion size. Polyp resection is in the midst of a "cold revolution," particularly for lesions <10 mm in size, but also for some larger lesions. Cold forceps are sometimes appropriate for 1- to 2-mm lesions that can be engulfed in one bite, but we use cold snaring for almost the entire set of lesions <10 mm...
June 14, 2018: Gastrointestinal Endoscopy
J E Yap, P Jaiswal, L Ton, R Szynkarek, B M Attar, S Gandhi
WHAT IS KNOWN AND OBJECTIVE: Elbasvir/grazoprevir is an all-oral regimen approved for patients with hepatitis C virus (HCV) genotypes 1 and 4, and in renal insufficiency. However, to date, no data exist on the efficacy of this regimen when it is crushed and administered through a percutaneous endoscopic gastrostomy (PEG) tube. Here, we illustrate the case of a 63-year-old man who is the only known patient with HCV infection in the English literature to have successfully achieved a sustained viral response (SVR) when elbasvir/grazoprevir oral combination was administered through a PEG tube...
June 15, 2018: Journal of Clinical Pharmacy and Therapeutics
Carolyn Moore, Leslie Ray Matthews, Omar Danner, Assad Taha, Aviva Bashan-Gilzenrat, Jonathan Nguyen, Ed Childs, Kahdi Udobi
To review the entity "black esophagus" and sequela of a slipped laparoscopic adjustable band. The patient's history, physical examination, imaging, and endoscopic findings were reviewed. Detailed review of pathophysiology, presentation, diagnosis, management, and natural history was conducted. "Black esophagus," also known as acute esophageal necrosis (AEN), is a rare condition resulting in black discoloration of the mid to distal esophagus with less than a hundred reported cases. It has not been previously documented in bariatric surgery or following laparoscopic adjustable gastric banding...
June 15, 2018: Obesity Surgery
Y Smadi, C Deb, J Bornstein, S Safder, K Horvath, D Mehta
Patients with eosinophilic esophagitis (EoE) require frequent evaluation of mucosal inflammation via endoscopy. Instead of endoscopy, mucosal evaluation in adults with esophageal cancer and candidiasis is achieved using a cytology brush inserted through a nasogastric tube (NGT). We conducted a prospective cross-sectional study in children and young adults scheduled for routine esophagogastroduodenoscopy (EGD) where in Phase 1, we performed esophageal brushing through the endoscope under direct visualization and in Phase 2, we inserted the brush through a Cortrak® NGT prior to endoscopy...
June 14, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Thomas Greuter, Ekaterina Safroneeva, Christian Bussmann, Luc Biedermann, Stephan R Vavricka, David A Katzka, Alain M Schoepfer, Alex Straumann
BACKGROUND & AIMS: Although swallowed topical corticosteroids (STCs) are effective in inducing remission of active eosinophilic esophagitis (EoE), there are few data on maintenance of long-term remission. We evaluated the long-term effectiveness of STC therapy for adults with EoE. METHODS: We performed a retrospective study using the Swiss EoE database. We analyzed data on 229 patients with EoE treated with STCs (175 male; mean age at diagnosis, 39±15 years; median time until diagnosis, 6 years) from 2000 through 2014...
June 11, 2018: Clinical Gastroenterology and Hepatology
Maham Hayat, Sultan Mahmood, John T Maple
A 62-year-old male with long-standing esophageal reflux underwent endoscopy at an outside institution that reported multiple polypoid lesions in upper esophagus and a small focal area of nodular mucosa at the gastroesophageal junction(GEJ). Biopsies of the proximal esophageal polyps demonstrated hyperplastic mucosa with ulceration, reactive epithelial changes, and focal intestinal metaplasia. Biopsies from the nodular GEJ mucosa were described as Barrett's esophagus with low grade dysplasia. An upper endoscopy performed at our medical center found multiple semi-pedunculated esophageal polyps between 18-24 cm from the incisors (Figure A)...
June 11, 2018: Clinical Gastroenterology and Hepatology
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