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https://www.readbyqxmd.com/read/28212588/colorectal-polypectomy-and-endoscopic-mucosal-resection-emr-european-society-of-gastrointestinal-endoscopy-esge-clinical-guideline
#1
Monika Ferlitsch, Alan Moss, Cesare Hassan, Pradeep Bhandari, Jean-Marc Dumonceau, Gregorios Paspatis, Rodrigo Jover, Cord Langner, Maxime Bronzwaer, Kumanan Nalankilli, Paul Fockens, Rawi Hazzan, Ian M Gralnek, Michael Gschwantler, Elisabeth Waldmann, Philip Jeschek, Daniela Penz, Denis Heresbach, Leon Moons, Arnaud Lemmers, Konstantina Paraskeva, Juergen Pohl, Thierry Ponchon, Jaroslaw Regula, Alessandro Repici, Matthew D Rutter, Nicholas G Burgess, Michael J Bourke
1 ESGE recommends cold snare polypectomy (CSP) as the preferred technique for removal of diminutive polyps (size ≤ 5 mm). This technique has high rates of complete resection, adequate tissue sampling for histology, and low complication rates. (High quality evidence, strong recommendation.) 2 ESGE suggests CSP for sessile polyps 6 - 9 mm in size because of its superior safety profile, although evidence comparing efficacy with hot snare polypectomy (HSP) is lacking. (Moderate quality evidence, weak recommendation...
February 17, 2017: Endoscopy
https://www.readbyqxmd.com/read/28210705/gastric-esd-may-be-useful-as-accurate-staging-and-decision-of-future-therapeutic-strategy
#2
Ai Fujimoto, Osamu Goto, Toshihiro Nishizawa, Yasutoshi Ochiai, Joichiro Horii, Tadateru Maehata, Teppei Akimoto, Satoshi Kinoshita, Seiji Sagara, Motoki Sasaki, Toshio Uraoka, Naohisa Yahagi
Background and study aims We sometimes perform gastric endoscopic submucosal dissection (ESD) for total pathologic diagnosis when preoperative diagnosis is difficult. In the present study we analyzed the treatment outcomes and adverse events of diagnostic ESD for early gastric cancer (EGC). Patients and methods We conducted a retrospective analysis of 18 consecutive cases of EGC in 18 patients with a suspected out-of-indication diagnosis who underwent diagnostic ESD, between June 2010 and November 2014...
February 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28210084/risk-factors-for-intraoperative-perforation-during-endoscopic-submucosal-dissection-of-superficial-esophageal-squamous-cell-carcinoma
#3
Masaaki Noguchi, Tomonori Yano, Tomoji Kato, Tomohiro Kadota, Maomi Imajoh, Hiroyuki Morimoto, Shozo Osera, Atsushi Yagishita, Tomoyuki Odagaki, Yusuke Yoda, Yasuhiro Oono, Hiroaki Ikematsu, Kazuhiro Kaneko
AIM: To identify the risk factors and clarify the subsequent clinical courses. METHODS: This study retrospectively analyzed consecutive patients with esophageal squamous cell carcinoma (ESCC) treated using endoscopic submucosal dissection (ESD) between April 2008 and October 2012. We divided the ESCC lesions into perforation cases and non-perforation cases, and compared characteristics and endoscopic findings between the two groups. "Intraoperative perforation" was defined as the detection of a perforation site during ESD and the presence of mediastinal emphysema...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28206943/limited-resection-of-the-duodenum-for-nonampullary-duodenal-tumors-with-review-of-the-literature
#4
Daisuke Hashimoto, Kota Arima, Akira Chikamoto, Katsunobu Taki, Risa Inoue, Takayoshi Kaida, Takaaki Higashi, Katsunori Imai, Toru Beppu, Hideo Baba
The surgical management of duodenal pathology is challenging because of its retroperitoneal position and shared blood supply with the pancreas. We present three types of limited resection of the duodenum for the removal of superficial or small nonampullary duodenal (NADL) lesions, and also a review of the English literature regarding management, such as endoscopic resection and limited duodenal resection. Ten cases underwent limited resections of the duodenum for superficial or small NADL lesions from 2011 to 2015...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28205059/clinical-application-of-early-gastric-carcinoma-with-lymphoid-stroma-based-on-lymph-node-metastasis-status
#5
Hyun Lim, In Seob Lee, Jeong Hoon Lee, Young Soo Park, Hyo Jeong Kang, Hee Kyong Na, Ji Yong Ahn, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Jin-Ho Kim, Beom Su Kim, Jeong Hwan Yook, Byung Sik Kim
BACKGROUND: Gastric carcinoma with lymphoid stroma (GCLS) is characterized by undifferentiated carcinoma mixed with prominent lymphoid infiltration. GCLS has unique clinicopathological features and a better prognosis compared to other types of gastric cancer. We analyzed the clinicopathological features of early GCLS in relation to lymph node metastasis (LNM). METHODS: We performed a retrospective analysis of 241 patients diagnosed with GCLS confined to the mucosa or the submucosa between March 1998 and December 2015...
February 15, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28205058/gastric-cancer-treated-by-endoscopic-submucosal-dissection-or-endoscopic-mucosal-resection-in-japan-from-2004-through-2006-jgca-nationwide-registry-conducted-in-2013
#6
Satoshi Tanabe, Shigeki Hirabayashi, Ichiro Oda, Hiroyuki Ono, Atsushi Nashimoto, Yoh Isobe, Isao Miyashiro, Shunichi Tsujitani, Yasuyuki Seto, Takeo Fukagawa, Souya Nunobe, Hiroshi Furukawa, Yasuhiro Kodera, Michio Kaminishi, Hitoshi Katai
BACKGROUND: The Japanese Gastric Cancer Association (JGCA) initiated a new nationwide gastric cancer registry in 2008 and reported the treatment outcomes of patients with primary gastric cancer who underwent surgical therapy in 2001 and 2003. However, the outcomes of endoscopic therapy have not been reported yet. METHODS: The JGCA conducted a retrospective nationwide registry in 2013 to investigate the short-term and long-term outcomes of endoscopic mucosal resection or endoscopic submucosal dissection in patients with gastric cancer treated from January 2004 through December 2006...
February 15, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28203472/cyanoacrylate-associated-foreign-body-granulomatous-gastritis-a-report-of-three-cases
#7
Gunes Guner, Olcay Kurtulan, Taylan Kav, Cenk Sokmensuer, Gokhan Gedikoglu, Aytekin Akyol
Granulomas are rarely seen in gastric biopsies mostly as an involvement of granulomatous diseases like sarcoidosis, Crohn's disease, infections, neoplasms, and vasculitis. Here, we claim cyanoacrylate as a foreign body type granuloma-causing agent in the stomach after vascular embolisation. We present cyanoacrylate associated gastric changes of three cases: two endoscopic biopsies and one gastric resection. In two cases, cyanoacrylate associated ulcers and granulomatous inflammation were observed in gastric mucosal biopsies following endoscopic examination after 7 months and 6 years of the glue injections, respectively...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28199735/novel-gastric-mucosal-findings-in-association-with-proton-pump-inhibitors
#8
EDITORIAL
Hajime Isomoto, Hiroki Kurumi
Proton pump inhibitors (PPIs) are prescribed worldwide as the treatment of choice for gastroesophageal reflux disease, and are known to exert preventive effects for upper gastrointestinal injuries due to aspirin or non-steroidal anti-inflammatory drugs. On the other hand, the long-term use of PPIs may cause such adverse events as fractures and enteric infections. Recently, they have been associated with mucosal changes including parietal cell protrusions, oxyntic gland dilatations and fundic gland polyps (FGPs)...
February 15, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28195539/endoscopic-balloon-dilation-for-stenotic-lesions-in-crohn-s-disease
#9
Akira Kanamori, Takeshi Sugaya, Keiichi Tominaga, Fumiaki Takahashi, Kazuhiro Takenaka, Atushi Hoshino, Takero Koike, Masakazu Nakano, Hideyuki Hiraishi
BACKGROUND/AIMS: Endoscopic balloon dilation (EBD) can serve as an alternative to surgery for intestinal stenosis associated with Crohn's disease (CD). However, there has been controversy regarding the efficacy and safety of EBD. Here we sought to determine the therapeutic efficacy and safety of EBD for intestinal stenosis in CD. MATERIALS AND METHODS: Of 43 patients with CD accompanied by intestinal stenosis, 30 underwent EBD. These 30 patients were examined retrospectively in terms of the scope passage rate, surgery-free rate, and whether or not the observation of the distal intestinal tract influenced the therapeutic strategy...
February 14, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28192823/incomplete-resection-rate-of-cold-snare-polypectomy-a-prospective-single-arm-observational-study
#10
Noriko Matsuura, Yoji Takeuchi, Takeshi Yamashina, Takashi Ito, Kenji Aoi, Kengo Nagai, Takashi Kanesaka, Fumi Matsui, Mototsugu Fujii, Tomofumi Akasaka, Noboru Hanaoka, Koji Higashino, Yasuhiko Tomita, Yuri Ito, Ryu Ishihara, Hiroyasu Iishi, Noriya Uedo
Background and study aims Cold snare polypectomy (CSP) is considered to be safe for the removal of subcentimeter colorectal polyps. This study aimed to determine the rate of incomplete CSP resection for subcentimeter neoplastic polyps at our center. Patients and methods Patients with small or diminutive adenomas (diameter 1 - 9 mm) were recruited to undergo CSP until no polyp was visible. After CSP, a 1 - 3 mm margin around the resection site was removed using endoscopic mucosal resection. The polyps and resection site marginal specimens were microscopically evaluated...
February 13, 2017: Endoscopy
https://www.readbyqxmd.com/read/28188060/mesenteric-findings-of-ct-enterography-are-well-correlated-with-the-endoscopic-severity-of-crohn-s-disease
#11
Takehiro Sakurai, Tatsuro Katsuno, Keiko Saito, Sayuri Yoshihama, Tomoo Nakagawa, Hirotaka Koseki, Takashi Taida, Hideaki Ishigami, Ken-Ichiro Okimoto, Daisuke Maruoka, Tomoaki Matsumura, Makoto Arai, Osamu Yokosuka
BACKGROUND: Maintenance of mucosal healing is a primary goal when treating Crohn's disease (CD). Endoscopy is the most precise method for the assessment of mucosal healing, but is considered overly invasive for patients with CD. In contrast, CT enterography (CTE) is less invasive, but little is known about the correlation between mucosal status and CTE parameters. METHODS: We recruited CD patients who underwent CTE and double balloon endoscopy (DBE) on the same day at our hospital between 2012 and 2014...
November 27, 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/28187035/hepatocyte-antigen-expression-in-barrett-esophagus-and-associated-neoplasia
#12
Sejal S Shah, Vishal S Chandan
Hepatocyte antigen or hepatocyte paraffin 1 (Hep Par 1) is widely used as a diagnostic immunomarker for hepatocellular carcinoma. It has also been identified as a rate-limiting enzyme of the urea cycle, carbamoyl phosphate synthetase 1. Hep Par 1 has been detected in non-neoplastic small intestinal epithelium, but its expression in Barrett esophagus and its related neoplasia has not been well investigated. We immunohistochemically evaluated expression of Hep Par 1 on 75 cases of Barrett esophagus (25 cases without dysplasia, 16 cases with low-grade dysplasia, 25 cases with high-grade dysplasia, and 9 cases with intramucosal adenocarcinoma) on endoscopic biopsies and endoscopic mucosal resections...
February 9, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28185972/optimizing-sellar-reconstruction-after-pituitary-surgery-with-free-mucosal-graft-results-in-the-first-50-consecutive-patients
#13
Maria Peris-Celda, Mark Chaskes, Daniel D Lee, Tyler J Kenning, Carlos D Pinheiro-Neto
BACKGROUND: Postoperative CSF leak after endoscopic pituitary surgery ranges from 1.9-10% in different series. Vascularized flaps have reduced the incidence of leak, however it carries nasal morbidity. This paper presents a technique for sellar reconstruction with free mucosal graft from the nasal cavity floor including inferior meatus mucosa. This technique aims to standardize sellar reconstruction without the use of the nasoseptal flap and keeping the advantage of mucosal coverage of the defect in all cases...
February 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28182092/the-interaction-between-gstt1-gstm1-and-gstp1-ile105val-gene-polymorphisms-and-environmental-risk-factors-in-premalignant-gastric-lesions-risk
#14
Anca Negovan, Mihaela Iancu, Valeriu Moldovan, Simona Mocan, Claudia Banescu
The study investigated the possible influence of GSTM1, GSTT1, and GSTP1 gene polymorphisms as predisposing factors for premalignant gastric lesions as well as their interaction with H. pylori infection, gastrotoxic drugs, smoking, and alcohol consumption. In this study, 270 patients with a complet set of gastric biopsies and successfully genotyped were finally included. The GSTM1 gene polymorphism had significant contribution in mild/severe endoscopic lesions (p = 0.01) as well as in premalignant lesions (p = 0...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28181699/endoscopic-closure-after-intraluminal-surgery
#15
REVIEW
Teppei Akimoto, Osamu Goto, Toshihiro Nishizawa, Naohisa Yahagi
Endoscopic submucosal dissection is established as a curative endoscopic method for gastrointestinal epithelial neoplasms with a high possibility of complete en bloc resection; however, postoperative adverse events of bleeding and delayed perforation remain. To prevent or minimize them, several techniques for endoscopic mucosal closure have been introduced, such as using endoscopic clips, combined use of hemoclips and supplement devices, and specially designed endoscopic suturing devices. Furthermore, endoscopic full-thickness suturing technique for gastrointestinal wall defect has been developed based on the concept in natural orifice transluminal endoscopic surgery and endoscopic full-thickness resection...
February 9, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28179979/flexible-gastro-intestinal-endoscopy-clinical-challenges-and-technical-achievements
#16
REVIEW
Niehls Kurniawan, Martin Keuchel
Flexible gastro-intestinal (GI) endoscopy is an integral diagnostic and therapeutic tool in clinical gastroenterology. High quality standards for safety, patients' comfort, and efficiency have already been achieved. Clinical challenges and technical approaches are discussed in this short review. Image enhanced endoscopy for further characterization of mucosal and vascular patterns includes dye-spray or virtual chromoendoscopy. For confocal laser endoscopy, endocytoscopy, and autofluorescence clinical value has not yet been finally evaluated...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/28175079/p319-accurate-cut-offs-for-predicting-endoscopic-activity-and-mucosal-healing-in-crohn-s-disease-with-fecal-calprotectin
#17
J M Vázquez-Morόn, B Benítez-Rodríguez, H Pallarés-Manrique, F H Machancoses, J L Robles Rodríguez, M Ramos-Lora, C Ruíz-Frutos
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174975/p159-real-time-endoscopic-guided-measurement-of-rectal-mucosal-admittance-a-novel-and-safety-method-for-prediction-of-relapse-in-ulcerative-colitis
#18
T Taida, T Nakagawa, M Fujie, Y Ohta, S Hamanaka, K Okimoto, K Saito, D Maruoka, T Matsumura, M Arai, T Katsuno
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174738/microgeographic-proteomic-networks-of-the-human-colonic-mucosa-and-their-association-with-inflammatory-bowel-disease
#19
Xiaoxiao Li, James LeBlanc, David Elashoff, Ian McHardy, Maomeng Tong, Bennett Roth, Andrew Ippoliti, Gildardo Barron, Dermot McGovern, Keely McDonald, Rodney Newberry, Thomas Graeber, Steve Horvath, Lee Goodglick, Jonathan Braun
BACKGROUND & AIMS: Interactions between mucosal cell types, environmental stressors, and intestinal microbiota contribute to pathogenesis in inflammatory bowel disease (IBD). Here, we applied metaproteomics of the mucosal-luminal interface to study the disease-related biology of the human colonic mucosa. METHODS: We recruited a discovery cohort of 51 IBD and non-IBD subjects endoscopically sampled by mucosal lavage at 6 colonic regions, and a validation cohort of 38 no-IBD subjects...
September 2016: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28174124/endoscopic-treatment-outcomes-of-laterally-spreading-tumors-with-a-skirt-with-video
#20
Shozo Osera, Hiroaki Ikematsu, Satoshi Fujii, Keisuke Hori, Yasuhiro Oono, Tomonori Yano, Kazuhiro Kaneko
BACKGROUND AND AIMS: A "skirt" is a slightly elevated flat lesion with wide pits occasionally observed at the margin of laterally spreading tumors (LSTs). However, the endoscopic treatment outcomes of LSTs with skirts have not been clarified. The aim of this study was to evaluate the endoscopic treatment outcomes of LSTs with skirts. METHODS: Between February 2006 and March 2014, 996 LSTs were retrospectively examined to assess the clinicopathological characteristics, procedure time, en bloc resection rate, R0 resection rate, adverse events, and local recurrence rate of endoscopic submucosal dissection (ESD); and the local recurrence rate of endoscopic resection...
February 4, 2017: Gastrointestinal Endoscopy
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