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endoscopic submucosal

Katsuki Yaguchi, Makomo Makazu, Kingo Hirasawa, Makoto Sugimori, Ryosuke Kobayashi, Chiko Sato, Ryosuke Ikeda, Takehide Fukuchi, Yasuaki Ishii, Hiroaki Kaneko, Wataru Shibata, Shoji Yamanaka, Yoshiaki Inayama, Shin Maeda
Stomach cancer rarely develops in patients with familial adenomatous polyposis (FAP), and Helicobacter pylori infection may increase the risk of FAP-related gastric cancer. We describe the case of a 64-year-old woman who developed multiple synchronous early gastric cancers without H. pylori infection. Nine cancer lesions were successfully treated by endoscopic submucosal dissection. An immunohistochemical analysis revealed that the tumors were positive for MUC2, MUC6, and CDX2, but negative for MUC5AC, suggesting that the tumors were gastrointestinal mixed type...
October 11, 2017: Internal Medicine
Sung Noh Hong
Long-standing intestinal inflammation in patients with inflammatory bowel disease (IBD) induces dysplastic change in the intestinal mucosa and increases the risk of subsequent colorectal cancer. The evolving endoscopic techniques and technologies, including dye spraying methods and high-definition images, have been replacing random biopsies and have been revealed as more practical and efficient for detection of dysplasia in IBD patients. In addition, they have potential usefulness in detailed characterization of lesions and in the assessment of endoscopic resectability...
September 2017: Clinical Endoscopy
Chang Seok Bang, Gwang Ho Baik
No abstract text is available yet for this article.
September 2017: Clinical Endoscopy
Dennis Yang, Fei Zou, Sican Xiong, Justin J Forde, Yu Wang, Peter V Draganov
BACKGROUND AND AIMS: The role of endoscopic submucosal dissection (ESD) in Barrett's esophagus (BE) is not well established. This meta-analysis aimed to evaluate the safety and efficacy of ESD for the management of early BE neoplasia. METHODS: Three online databases were searched. The Cochran Q test and I(2) were used to test for heterogeneity. Pooling was conducted using either fixed- or random-effects models depending on heterogeneity across studies. For the main outcomes, potential sources of heterogeneity were evaluated via linear regression analysis...
October 6, 2017: Gastrointestinal Endoscopy
Ai Fujimoto, Toshio Uraoka, Toshihiro Nishizawa, Masayuki Shimoda, Osamu Goto, Yasutoshi Ochiai, Tadateru Maehata, Teppei Akimoto, Yutaka Mitsunaga, Motoki Sasaki, Hiroyuki Yamamoto, Naohisa Yahagi
BACKGROUND AND AIMS: Rebamipide was administered perorally to protect the gastric mucosa. We assessed the efficacy and safety of a novel rebamipide solution as a submucosal injection material for endoscopic submucosal dissection (ESD) using an in vivo porcine model. METHODS: An endoscopist blinded to the test agents performed ESDs of hypothetical 30 mm lesions using a 2% rebamipide solution at 2 sites (rebamipide group) and a saline solution at the two other sites (control group) in the stomachs of 8 pigs...
October 6, 2017: Gastrointestinal Endoscopy
José Rodrigues, Pedro Barreiro, Joana Carmo, Lídia Ramos, Cristina Chagas
No abstract text is available yet for this article.
October 9, 2017: Endoscopy
Gaspard Bertrand, Jérémie Jacques, Jérôme Rivory, Florian Rostain, Jean-Christophe Saurin, Thierry Ponchon, Mathieu Pioche
No abstract text is available yet for this article.
October 9, 2017: Endoscopy
Shigeo Banno, Toshihiro Nishizawa, Satoshi Kinoshita, Hideki Mori, Toshio Uraoka
No abstract text is available yet for this article.
October 9, 2017: Endoscopy
Farzan F Bahin, Steven J Heitman, Khalid N Rasouli, Hema Mahajan, Duncan McLeod, Eric Y T Lee, Stephen J Williams, Michael J Bourke
OBJECTIVE: To compare the cost-effectiveness of endoscopic submucosal dissection (ESD) and wide-field endoscopic mucosal resection (WF-EMR) for removing large sessile and laterally spreading colorectal lesions (LSLs)> 20 mm. DESIGN: An incremental cost-effectiveness analysis using a decision tree model was performed over an 18-month time horizon. The following strategies were compared: WF-EMR, universal ESD (U-ESD) and selective ESD (S-ESD) for lesions highly suspicious for containing submucosal invasive cancer (SMIC), with WF-EMR used for the remainder...
October 7, 2017: Gut
Zhi-Peng Qi, Qing Shi, Jing-Zheng Liu, Li-Qing Yao, Mei-Dong Xu, Shi-Lun Cai, Bing Li, Iri Take, Yi-Qun Zhang, Wei-Feng Chen, Yun-Shi Zhong, Ping-Hong Zhou
BACKGROUND AND AIMS: Endoscopic submucosal dissection (ESD) of colorectal submucosal tumors (SMTs) is becoming increasingly common; however, there have been few large consecutive studies analyzing its therapeutic efficacy and safety. The aim of this study was to evaluate the efficacy, safety, and long-term outcomes of ESD for colorectal SMTs. METHODS: This retrospective study included 412 consecutive patients with colorectal SMTs who underwent ESD at the Zhongshan Hospital of Fudan University from January 2008 to July 2014...
October 4, 2017: Gastrointestinal Endoscopy
Waku Hatta, Takuji Gotoda, Tsuneo Oyama, Noboru Kawata, Akiko Takahashi, Yoshikazu Yoshifuku, Shu Hoteya, Masahiro Nakagawa, Masaaki Hirano, Mitsuru Esaki, Mitsuru Matsuda, Ken Ohnita, Kohei Yamanouchi, Motoyuki Yoshida, Osamu Dohi, Jun Takada, Keiko Tanaka, Shinya Yamada, Tsuyotoshi Tsuji, Hirotaka Ito, Yoshiaki Hayashi, Tomohiro Nakamura, Naoki Nakaya, Tooru Shimosegawa
BACKGROUND: We have established a risk-scoring system, termed the "eCura system," for the risk stratification of lymph node metastasis in patients who have received noncurative endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). We aimed to clarify whether this system contributes to the selection of patients requiring radical surgery after ESD. METHODS: Between 2000 and 2011, 1,969 patients with noncurative ESD for EGC were included in this multicenter study...
October 5, 2017: Gastric Cancer
Masayuki Itabashi, Anna Nasierowska-Guttmejer, Tadakazu Shimoda, Przemysław Majewski, Witold Rezner, Katarzyna Sikora, Ewa Śrutek, Katarzyna Stęplewska, Jarosław Swatek, Justyna Szumilo, Agnieszka Wierzchniewska-Ławska, Lech Wronecki, Ewa Zembala-Nożyńska, Tomio Arai, Masahiro Fujita, Hiroshi Kawachi, Masamitsu Unakami, Toshiro Kamoshida
BACKGROUND: There are differences in the histological diagnostic criteria for early stage gastrointestinal carcinoma between Western and Japanese pathologists. Western histological criteria of carcinoma are "presence of stromal invasion of neoplastic cells", while Japanese criteria are "the degree of cytological and structural abnormality of neoplastic cells, regardless of stromal invasion". The aim of the present study is to clarify and review the present status of the Western and Japanese histological criteria of early stage esophageal squamous cell carcinoma (SCC) and also to clarify their significance and accuracy...
2017: Esophagus: Official Journal of the Japan Esophageal Society
Yuto Shimamura, Takashi Ikeya, Norman Marcon, Jeffrey D Mosko
Esophageal cancer is one of the leading causes of cancer-related death and is associated with high morbidity and mortality. It carries a poor prognosis as more than half of patients present with advanced and unresectable disease. One contributing factor is the increased risk of lymph node metastases at early stages of disease. As such, it is essential to detect squamous cell neoplasia (SCN) at an early stage. In order to risk stratify lesions, endoscopists must be able to perform image enhanced endoscopy including magnification and Lugol's chromoendoscopy...
September 16, 2017: World Journal of Gastrointestinal Endoscopy
Dae-Seong Myung, Sun-Seog Kweon, Jun Lee, Ik-Sang Shin, Sang-Wook Kim, Geom-Seog Seo, Hyun-Soo Kim, Young-Eun Joo
BACKGROUND AND AIMS: Laterally spreading colorectal tumors (LSTs) are divided into four subtypes, including homogenous (HG), nodular mixed (NM), flat elevated (FE), and pseudo-depressed (PD), based on their different endoscopic morphologies. The aim of this study was to investigate the clinicopathological significance of LST subtypes and their association with advanced histology. METHODS: We investigated the medical records of consecutive patients with LST who initially underwent endoscopic resection at five university hospitals in Honam province of South Korea between January 2012 and December 2013...
2017: PloS One
Katrin Schwameis, Kyle M Green, Stephanie G Worrell, Jamil Samaan, Shannon Cooper, Sergei Tatishchev, Daniel S Oh, Jeffrey A Hagen, Steven R DeMeester
BACKGROUND: Intramucosal esophageal adenocarcinoma can be reliably treated endoscopically. Controversy exists about the use of endotherapy versus esophagectomy for submucosal tumors. Increasingly endotherapy is considered for submucosal tumors in part because of the presumed high mortality with esophagectomy and the perceived poor prognosis in patients with nodal disease. This study was designed to assess survival following primary en bloc esophagectomy (EBE) in patients with submucosal esophageal adenocarcinoma (EAC)...
October 3, 2017: Annals of Surgical Oncology
Mohamed M Abdelfatah, Mohamed Barakat, Hyuk Lee, Jae J Kim, Noriya Uedo, Ian Grimm, Mohamed O Othman
BACKGROUND: Japanese criteria for curative endoscopic resection of early gastric cancer initially included non-ulcerated, well-differentiated mucosal lesions ≤2 cm in diameter, known as the absolute criteria. Subsequently, these indications were expanded to include larger, ulcerated and undifferentiated mucosal lesions as well as differentiated lesions with slight submucosal invasion (SM1). Whether patients meeting the expanded criteria (Ex) can be safely managed without gastrectomy and lymph node dissection has been controversial...
September 28, 2017: Gastrointestinal Endoscopy
Yasushi Yamasaki, Noriya Uedo, Yoji Takeuchi, Koji Higashino, Noboru Hanaoka, Tomofumi Akasaka, Minoru Kato, Kenta Hamada, Yusuke Tonai, Noriko Matsuura, Takashi Kanesaka, Masamichi Arao, Sho Suzuki, Taro Iwatsubo, Satoki Shichijo, Hiroko Nakahira, Ryu Ishihara, Hiroyasu Iishi
Background and study aim Underwater endoscopic mucosal resection (UEMR) was recently developed in a Western country. A prospective cohort study to investigate the effectiveness of UEMR was conducted in patients with small superficial nonampullary duodenal adenomas. Patients and methods Patients with duodenal adenomas ≤ 20 mm were enrolled. After the duodenal lumen had been filled with physiological saline, UEMR was performed without submucosal injection. Endoclip closure was attempted for all mucosal defects after UEMR...
September 29, 2017: Endoscopy
Daisuke Chinda, Tadashi Shimoyama, Shiro Hayamizu, Kuniaki Miyazawa, Tetsu Arai, Miyuki Yanagimachi, Toshiaki Tsukamoto, Tatsuya Mikami, Shinsaku Fukuda
The aim of this study was to investigate the change in the energy metabolism and invasiveness in the perioperative period of endoscopic submucosal dissection for early gastric cancer. Fifty-two consecutive patients were enrolled into the study between July 2013 and May 2014 and examined resting energy expenditure using an indirect calorimeter, body weight and basal energy expenditure using the Harris-Benedict equation before and after endoscopic submucosal dissection. Resting energy expenditure/body weight and resting energy expenditure/basal energy expenditure were 20...
September 2017: Journal of Clinical Biochemistry and Nutrition
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