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feline cancer

Jin Tian, Xiaoliang Hu, Dafei Liu, Hongxia Wu, Liandong Qu
Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. Using cell models of feline calicivirus (FCV), we demonstrated that IOP treatment was capable of exhibiting anti-FCV strain F9 activity in cell-based assays and also showed low cytotoxicity. Investigation of the mechanism of action of the compound revealed that IOP treatment induces its inhibitory actions directly on virus particles through blocking viral binding/absorpting...
November 16, 2016: International Journal of Biological Macromolecules
Radmehr Shafiee, Javad Javanbakht, Nahid Atyabi, Alimohammad Bahrami, Danial Kheradmand, Reyhaneh Safaei, Farshid Khadivar, Ehsan Hosseini
No abstract text is available yet for this article.
November 2, 2016: Diagnostic Pathology
Hidenori Fujita, Akira Gomori, Yayoi Fujioka, Yuki Kataoka, Kenji Tanaka, Akihiro Hashimoto, Takamasa Suzuki, Kenjiro Ito, Tomonori Haruma, Hiromi Yamamoto-Yokoi, Naomoto Harada, Motomu Sakuragi, Nobuyuki Oda, Kenichi Matsuo, Masaki Inada, Kazuhiko Yonekura
Approximately 25-40% of patients with lung cancer show bone metastasis. Bone modifying agents reduce skeletal-related events (SREs), but they do not significantly improve overall survival. Therefore, novel therapeutic approaches are urgently required. In this study, we investigated the anti-tumor effect of TAS-115, a VEGFRs and HGF receptor (MET)-targeted kinase inhibitor, in a tumor-induced bone disease model. A549-Luc-BM1 cells, an osteo-tropic clone of luciferase-transfected A549 human lung adenocarcinoma cells (A549-Luc), produced aggressive bone destruction associated with tumor progression after intra-tibial (IT) implantation into mice...
2016: PloS One
Moustafa R K Ali, Ibrahim M Ibrahim, Hala R Ali, Salah A Selim, Mostafa A El-Sayed
Plasmonic photothermal therapy (PPTT) is a cancer therapy in which gold nanorods are injected at the site of a tumor before near-infrared light is transiently applied to the tumor causing localized cell death. Previously, PPTT studies have been carried out on xenograft mice models. Herein, we report a study showing the feasibility of PPTT as applied to natural tumors in the mammary glands of dogs and cats, which more realistically represent their human equivalents at the molecular level. We optimized a regime of three low PPTT doses at 2-week intervals that ablated tumors mainly via apoptosis in 13 natural mammary gland tumors from seven animals...
2016: International Journal of Nanomedicine
Birgitt Wolfesberger, Andrea Fuchs-Baumgartinger, Juraj Hlavaty, Florian R Meyer, Martin Hofer, Ralf Steinborn, Christiane Gebhard, Ingrid Walter
Osteosarcoma is considered the most common bone cancer in cats and dogs, with cats having a much better prognosis than dogs, since the great majority of dogs with osteosarcoma develop distant metastases. In search of a factor possibly contributing to this disparity, the stem cell growth factor receptor KIT was targeted, and the messenger (m)RNA and protein expression levels of KIT were compared in canine vs. feline osteosarcomas, as well as in normal bone. The mRNA expression of KIT was quantified by reverse transcription-quantitative polymerase chain reaction, and was observed to be significantly higher in canine (n=14) than in feline (n=5) osteosarcoma samples (P<0...
October 2016: Oncology Letters
Dmitriy Smolensky, Kusum Rathore, Jennifer Bourn, Maria Cekanova
Anthracycline-based chemotherapy, such as doxorubicin (Dox), while effective against many solid tumors, is not widely used for head and neck cancers. In this study, we evaluated the efficacy of Dox, and its derivative AD198 in human, canine, and feline oral squamous cell carcinomas cells (OSCC) in vitro. Dox and AD198 had significant an anti-proliferative effect on human, canine, and feline OSCC cells in dose-dependent manner. AD198 inhibited cell proliferation more effectively than Dox in tested OSCC cells...
September 20, 2016: Journal of Cellular Biochemistry
Antonio Giuliano, Rebecca Swift, Callum Arthurs, Georgina Marote, Francesca Abramo, Jenny McKay, Calum Thomson, Mariana Beltran, Michael Millar, Simon Priestnall, Jane Dobson, Fernando Costantino-Casas, Terry Petrou, Imelda M McGonnell, Anthony J Davies, Malcolm Weetman, Oliver A Garden, John R Masters, Christopher Thrasivoulou, Aamir Ahmed
Feline oral squamous cell carcinoma (FOSCC) is an aggressive neoplasm in cats. Little is known about the possible molecular mechanisms that may be involved in the initiation, maintenance and progression of FOSCC. Wnt signalling is critical in development and disease, including many mammalian cancers. In this study, we have investigated the expression of Wnt signalling related proteins using quantitative immunohistochemical techniques on tissue arrays. We constructed tissue arrays with 58 individual replicate tissue samples...
2016: PloS One
Hang Zhao, Yuening Cheng, Jianke Wang, Peng Lin, Li Yi, Yaru Sun, Jingqiang Ren, Mingwei Tong, Zhigang Cao, Jiawei Li, Jinliang Deng, Shipeng Cheng
Canine parvovirus (CPV) reproduces by co-opting the resources of host cells, inevitably causing cytotoxic effects to the host cells. Feline kidney F81 cells are sensitive to CPV infection and show disparate growing statuses at different time points post-infection. This study analysed the response of F81 cells to CPV infection at successive infection time points by iTRAQ-based quantitative proteomics. Differentially expressed proteins (DEPs) during 60 h of infection and at selected time points post-infection were identified by an analysis of variance test and a two-tailed unpaired t test, respectively...
2016: Scientific Reports
Gaofeng Fan, Siwei Zhang, Yan Gao, Peter A Greer, Nicholas K Tonks
Ovarian cancer cells disseminate readily within the peritoneal cavity, which promotes metastasis, and are often resistant to chemotherapy. Ovarian cancer patients tend to present with advanced disease, which also limits treatment options; consequently, new therapies are required. The oncoprotein tyrosine kinase MET, which is the receptor for hepatocyte growth factor (HGF), has been implicated in ovarian tumorigenesis and has been the subject of extensive drug development efforts. Here, we report a novel ligand- and autophosphorylation-independent activation of MET through the nonreceptor tyrosine kinase feline sarcoma-related (FER)...
July 1, 2016: Genes & Development
K Ochiai, H Oda, S Shono, Y Kato, S Sugihara, S Nakazawa, D Azakami, M Michishita, E Onozawa, M Bonkobara, T Sako, L Shun-Ai, H Ueki, M Watanabe, T Omi
Reduced expression in immortalized cells (REIC/Dkk-3), a member of the human Dickkopf (Dkk) family, is a growth suppressor in human and canine mammary tumours. Mammary gland tumours are common neoplasms with high malignancy in female cats. The purpose of this study was to clone the feline REIC/Dkk-3 homolog, investigate its expression in cell lines established from feline mammary gland tumours, and test its tumour suppressor function. Western blot analysis revealed that expression of the REIC/Dkk-3 protein was reduced in feline mammary carcinoma cell lines...
June 29, 2016: Veterinary and Comparative Oncology
C Crozier, G A Wood, R A Foster, S Stasi, J H W Liu, J M S Bartlett, B L Coomber, V S Sabine
Companion animals may serve as valuable models for studying human cancers. Although KRAS is the most commonly mutated gene in human ductal pancreatic cancers (57%), with mutations frequently occurring at codons 12, 13 and 61, human pancreatic acinar cell carcinomas (ACCs) lack activating KRAS mutations. In the present study, 32 pancreatic ACC samples obtained from 14 dogs and 18 cats, including seven metastases, were analyzed for six common activating KRAS mutations located in codons 12 (n = 5) and 13 (n = 1) using Sequenom MassARRAY...
July 2016: Journal of Comparative Pathology
B B Hassan, S M Elshafae, W Supsavhad, J K Simmons, W P Dirksen, S M Sokkar, T J Rosol
Feline mammary carcinoma (FMC) is similar to human breast cancer in the late age of onset, incidence, histopathologic features, biological behavior, and pattern of metastasis. Therefore, FMC has been proposed as a relevant model for aggressive human breast cancer. The goals of this study were to develop a nude mouse model of FMC tumor growth and metastasis and to measure the expression of genes responsible for lymphangiogenesis, angiogenesis, tumor progression, and lymph node metastasis in FMC tissues and cell lines...
June 8, 2016: Veterinary Pathology
Barb Biller, John Berg, Laura Garrett, David Ruslander, Richard Wearing, Bonnie Abbott, Mithun Patel, Diana Smith, Christine Bryan
All companion animal practices will be presented with oncology cases on a regular basis, making diagnosis and treatment of cancer an essential part of comprehensive primary care. Because each oncology case is medically unique, these guidelines recommend a patient-specific approach consisting of the following components: diagnosis, staging, therapeutic intervention, provisions for patient and personnel safety in handling chemotherapy agents, referral to an oncology specialty practice when appropriate, and a strong emphasis on client support...
July 2016: Journal of the American Animal Hospital Association
Marcela Solange Villaverde, Alexandra Marisa Targovnik, María Victoria Miranda, Liliana María Elena Finocchiaro, Gerardo Claudio Glikin
Progress in comparative oncology promises advances in clinical cancer treatments for both companion animals and humans. In this context, feline mammary carcinoma (FMC) cells have been proposed as a suitable model to study human breast cancer. Based on our previous data about the advantages of using type I interferon gene therapy over the respective recombinant DNA derived protein, the present work explored the effects of feline interferon-ω gene (fIFNω) transfer on FMC cells. Three different cell variants derived from a single spontaneous highly aggressive FMC tumor were successfully established and characterized...
August 2016: Cytokine
M E Gray, S Lee, A L McDowell, M Erskine, Q T M Loh, O Grice, D J Argyle, G T Bergkvist
Members of the epidermal growth factor receptor (EGFR/ERBB) gene family are frequently dysregulated in a range of human cancers, and therapeutics targeting these proteins are in clinical use. We hypothesized that similar pathways are involved in feline and canine tumours and that the same drugs may be of clinical use in veterinary patients. We investigated EGFR and ERBB2 targeting using a panel of feline and canine cell lines. EGFR and ERBB2 were targeted with siRNAs or tyrosine kinase inhibitors (TKIs) and their effect on cellular proliferation, colony formation and migration was investigated in vitro...
May 27, 2016: Veterinary and Comparative Oncology
Maria Soares, Sara Madeira, Jorge Correia, Maria Peleteiro, Fátima Cardoso, Fernando Ferreira
Molecular classification of feline mammary carcinomas (FMC) from which specific behavioral patterns may be estimated has potential applications in veterinary clinical practice and in comparative oncology. In this perspective, the main goal of this study was to characterize both the clinical and the pathological features of the different molecular phenotypes found in a population of FMC (n = 102), using the broadly accepted IHC-based classification established by St. Gallen International Expert Consensus panel...
June 2016: Breast: Official Journal of the European Society of Mastology
John S Munday, Mike W Benfell, Adrienne French, Geoff M B Orbell, Neroli Thomson
BACKGROUND: Bowenoid in situ carcinomas (BISCs) are rare feline tumours that are thought to be caused by papillomavirus infection. Although they usually develop in old cats and are slowly progressive, multiple aggressive BISCs have been reported previously in a comparatively young Devon Rex cat. ANIMALS: A 5-year-old (Case 1) and an 8-year-old (Case 2) Devon Rex cat developed numerous BISCs. Rapid progression resulted in euthanasia of both cats after 8 months...
June 2016: Veterinary Dermatology
Juwita Hübner, Shahabuddin S Hoseini, Julia D Suerth, Dirk Hoffmann, Marcel Maluski, Jessica Herbst, Holger Maul, Arnab Ghosh, Britta Eiz-Vesper, Qinggong Yuan, Michael Ott, Michael Heuser, Axel Schambach, Martin G Sauer
Retroviral engineering of hematopoietic stem cell-derived precursor T-cells (preTs) opens the possibility of targeted T-cell transfer across human leukocyte antigen (HLA)-barriers. Alpharetroviral vectors exhibit a more neutral integration pattern thereby reducing the risk of insertional mutagenesis. Cord blood-derived CD34+ cells were transduced and differentiated into preTs in vitro. Two promoters, elongation-factor-1-short-form, and a myeloproliferative sarcoma virus variant in combination with two commonly used envelopes were comparatively assessed choosing enhanced green fluorescent protein or a third-generation chimeric antigen receptor (CAR) against CD123 as gene of interest...
August 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
Kathryn L Gilroy, Anne Terry, Asif Naseer, Jeroen de Ridder, Amin Allahyar, Weiwei Wang, Eric Carpenter, Andrew Mason, Gane K-S Wong, Ewan R Cameron, Anna Kilbey, James C Neil
Retroviruses have been foundational in cancer research since early studies identified proto-oncogenes as targets for insertional mutagenesis. Integration of murine gamma-retroviruses into the host genome favours promoters and enhancers and entails interaction of viral integrase with host BET/bromodomain factors. We report that this integration pattern is conserved in feline leukaemia virus (FeLV), a gamma-retrovirus that infects many human cell types. Analysis of FeLV insertion sites in the MCF-7 mammary carcinoma cell line revealed strong bias towards active chromatin marks with no evidence of significant post-integration growth selection...
2016: PloS One
C H Merrick, J Pierro, S E Schleis, E A Sones, Z M Wright, R C Regan, C T Siedlecki, P J Bergman
The purpose of this study was to describe the toxicity profile of toceranib phosphate in tumour bearing cats. Medical records were reviewed from seven institutions. Patients with incomplete medical records and those receiving concurrent chemotherapy or NSAIDs (non-steroidal anti-inflammatory) were excluded. Fifty-five cats met the inclusion criteria. Carcinoma was diagnosed in 55% of cases. Median oral toceranib dose was 2.7 mg kg(-1) and was most commonly administered on Monday, Wednesday and Friday. Thrombocytopenia (16...
April 4, 2016: Veterinary and Comparative Oncology
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