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https://www.readbyqxmd.com/read/29667763/prospective-randomized-study-of-sexual-function-in-men-taking-dutasteride-for-the-treatment-of-androgenetic-alopecia
#1
Tsen-Fang Tsai, Gwang Seong Choi, Beom Joon Kim, Moon-Bum Kim, Chi Fai Ng, Puja Kochhar, Stacy Jasper, Betsy Brotherton, Barbara Orban, Zrinka Lulic
Treatment with 5α-reductase inhibitors has been associated with sexual adverse events such as impotence (erectile dysfunction) and decreased libido. The primary objective of this study was to evaluate adverse events related to sexual function, based on their frequency, duration, persistence and associated treatment discontinuations, in men treated with dutasteride for androgenetic alopecia. Participants were randomized to receive double-blind dutasteride 0.5 mg or placebo once daily for 24 weeks, followed by open-label dutasteride 0...
April 18, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29656764/prescribing-habits-for-androgenic-alopecia-among-dermatologists-in-spain-in-2017-a-cross-sectional-study
#2
C Pindado-Ortega, D Saceda-Corralo, D Buendía-Castaño, P Fernández-González, Ó M Moreno-Arrones, P Fonda-Pascual, A Alegre-Sánchez, A R Rodrigues-Barata, S Vañó-Galván
BACKGROUND: Topical minoxidil and oral finasteride are the only drugs approved for the treatment of androgenetic alopecia (AGA) in Spain. However, the management of this condition is highly variable because numerous treatments are used off-label. The main aim of this study was to describe the prescribing habits of dermatologists in Spain for male AGA (MAGA) and female AGA (FAGA). MATERIAL AND METHODS: Descriptive cross-sectional study using online questionnaires completed by dermatologists working in Spain...
April 12, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29642315/re-comparing-clinical-and-economic-outcomes-associated-with-early-initiation-of-combination-therapy-of-an-alpha-blocker-and-dutasteride-or-finasteride-in-men-with-benign-prostatic-hyperplasia-in-the-united-states
#3
https://www.readbyqxmd.com/read/29608891/change-of-the-5%C3%AE-5%C3%AE-ratio-of-urinary-steroid-metabolites-in-benign-prostatic-hyperplasia-patients-treated-with-dutasteride
#4
Takahiro Maeda, Eiji Kikuchi, Masanori Hasegawa, Keiko Homma, Yota Yasumizu, Seiya Hattori, Takeo Kosaka, Kazunobu Shinoda, Akira Miyajima, Mototsugu Oya
BACKGROUND: The effects of the administration of dutasteride (DUT) on steroid metabolite pathways in BPH patients have not been examined. METHODS: Urine and blood samples as well as clinical parameters were prospectively collected after the administration of DUT to 60 BPH patients, and after its withdrawal in another set of 25 BPH patients. Urine samples were assessed using gas chromatography/mass spectrometry for the urinary steroid profile (USP), which simultaneously measures 63 steroid metabolites...
March 30, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29541409/inhibition-of-dihydrotestosterone-synthesis-in-prostate-cancer-by-combined-frontdoor-and-backdoor-pathway-blockade
#5
Michael V Fiandalo, John J Stocking, Elena A Pop, John H Wilton, Krystin M Mantione, Yun Li, Kristopher M Attwood, Gissou Azabdaftari, Yue Wu, David S Watt, Elizabeth M Wilson, James L Mohler
Androgen deprivation therapy (ADT) is palliative and prostate cancer (CaP) recurs as lethal castration-recurrent/resistant CaP (CRPC). One mechanism that provides CaP resistance to ADT is primary backdoor androgen metabolism, which uses up to four 3α-oxidoreductases to convert 5α-androstane-3α,17β-diol (DIOL) to dihydrotestosterone (DHT). The goal was to determine whether inhibition of 3α-oxidoreductase activity decreased conversion of DIOL to DHT. Protein sequence analysis showed that the four 3α-oxidoreductases have identical catalytic amino acid residues...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29469777/hormonal-therapies-for-hidradenitis-suppurativa-review
#6
Ashley K Clark, Rebecca L Quinonez, Suzana Saric, Raja K Sivamani
Hidradenitis suppurativa is a recurrent inflammatory skin condition characterized by abscesses and boils, predominantly in the groin, armpit, and buttocks areas. HS is not a life-threatening condition, but severely impairs quality of life in those affected. Finding a successful treatment approach for HS has been challenging, in part because of the lack of a gold-standard treatment method, limited research-based information, and the nature of clinical variation in the disease. Treatment commonly consists of antibiotics, anti-inflammatory therapy, hormonal therapy, and more invasive clinical procedures...
November 12, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29461667/computer-vision-detects-subtle-histological-effects-of-dutasteride-on-benign-prostate
#7
Amit Sethi, Lingdao Sha, Neeraj Kumar, Virgilia Macias, Ryan J Deaton, Peter H Gann
OBJECTIVE: To determine whether a computer vision-based approach applied to H&E prostate biopsy images can distinguish dutasteride-treated tissue from placebo, and identify features associated with degree of responsiveness to 5α-reductase inhibitor (5ARI) therapy. SUBJECTS AND METHODS: Our study population comprised 100 treatment-compliant men without prostate cancer assigned to dutasteride or placebo in the REDUCE trial who had slides available from mandatory Year 4 biopsies...
February 20, 2018: BJU International
https://www.readbyqxmd.com/read/29447628/sexual-side-effects-of-5-%C3%AE-reductase-inhibitors-finasteride-and-dutasteride-a-comprehensive-review
#8
Raymond M Fertig, A Caresse Gamret, Evan Darwin, Sudeep Gaudi
The 5-α-reductase inhibitors finasteride and dutasteride are frequently used in the treatment of androgenetic alopecia and benign prostatichyperplasia. These drugs are effective at reducing levels of dihydrotestosterone, the primary androgen responsible for the pathogenesis of both these conditions. However, finasteride and dutasteride have also been shown to produce an increase in the incidence of sexual dysfunction, namely, impotence, decreased libido, and ejaculation disorder. The purpose of this study is to review the existing medical literature with regard to the sexual side effects of 5-α-reductase inhibitor therapy...
November 11, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29434054/influence-of-dutasteride-and-nifedipine-on-catsper-gene-expression-in-epididymis-of-mice
#9
Archana Srivastav, Bendangla Changkija, Kunal Sharan, Geet Kumar Nagar, Falgun Wanganuji Bansode
Calcium (Ca2+) signaling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility and the acrosome reaction are all mediated by increases in intracellular Ca2 + through CatSper (sperm specific cation channel). The CatSper channel complex contains four pore forming α subunits (CatSper1-4 ) and five accessory subunits called β, δ, ε, γ and ζ . Genetic deletion of any of the four CatSper genes in mice results in loss of hyperactivated motility and male infertility...
February 6, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29406237/a-68-year-old-man-with-chronic-myelogenous-leukemia-and-a-large-unilateral-pleural-effusion
#10
Adam Alter, Neal Chaisson, Sudipto Mukherjee, Thomas Gildea
A 68-year-old man with chronic myelogenous leukemia presents for evaluation of 2 months of dyspnea with exertion. He denies cough, fever, chest pain, weight gain, orthopnea, and edema. Since diagnosis of chronic myelogenous leukemia 5 years ago, he has been treated with dasatinib, with recent BCR-ABL1 assay showing no detectable disease in the peripheral blood. Medical history also includes hyperlipidemia, prostate enlargement, and hypothyroidism, but no prior heart or lung disease. Born in the Middle East, he immigrated to the United States 30 years ago and is working as a physician...
February 2018: Chest
https://www.readbyqxmd.com/read/29387405/effect-of-dutasteride-on-castration-resistant-prostate-cancer
#11
Takeshi Azuma, Yukihide Matayoshi, Yujiro Sato, Yasuhi Nagase
It has previously been demonstrated that the intratumoral generation of the potent androgen dihydrotestosterone (DHT), contributes critically to the progression of prostate cancer and its castration-resistant form, castration-resistant prostate cancer (CRPC). Circulating testosterone is converted into DHT by 5α-reductase (SRD5A). Dutasteride is a dual inhibitor of type I and II SRD5A. The present study assessed the effectiveness of dutasteride in the treatment of CRPC. Between 2010 and 2013, CRPC was diagnosed in 41 patients at the Tokyo Metropolitan Tama Medical Center...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29379733/the-use-of-5-alpha-reductase-inhibitors-in-the-treatment-of-benign-prostatic-hyperplasia
#12
REVIEW
Eric H Kim, John A Brockman, Gerald L Andriole
Benign prostatic hyperplasia (BPH) is characterized by an enlarged prostate, lower urinary tract symptoms (LUTS), and a decreased urinary flow rate. Common in older men, BPH is a progressive disease that can eventually lead to complications including acute urinary retention (AUR) and the need for BPH-related surgery. Both normal and abnormal prostate growth is driven by the androgen dihydrotestosterone (DHT), which is formed from testosterone under the influence of 5-alpha reductase. Thus, 5-alpha reductase inhibitors (5-ARIs) effectively reduce the serum and intraprostatic concentration of DHT, causing an involution of prostate tissue...
January 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29368380/risk-of-rhabdomyolysis-from-5-%C3%AE-reductase-inhibitors
#13
Blayne Welk, Eric McArthur, Michael Ordon, Jade Dirk, Stephanie Dixon, Amit X Garg
PURPOSE: A recent regulatory warning and case reports have described the development of muscle complications with the use of 5-α reductase inhibitors (5ARIs). We wished to determine if there was a link between rhabdomyolysis and 5ARI usage. METHODS: We used a matched cohort design and linked administrative data from the province of Ontario, Canada, to investigate the risk of rhabdomyolysis in men using either finasteride or dutasteride. A total of 99 covariates were measured...
January 25, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29363345/androgenetic-alopecia-drug-safety-and-therapeutic-strategies
#14
REVIEW
Ion G Motofei, David L Rowland, Daniela L Baconi, Mircea Tampa, Maria-Isabela Sârbu, Stana Păunică, Vlad D Constantin, Cristian Bălălău, Ioana Păunică, Simona Roxana Georgescu
Androgenetic alopecia (AGA) is a benign condition with variable psychosocial impact, with some individuals adapting well while others needing therapeutic support. Although 5α-reductase inhibitors like finasteride and dutasteride have proven effective in ameliorating AGA, their use/selection is currently a subject of debate. Areas covered: Treatment of AGA with 5α-reductase inhibitors lead to variable adverse effects and relatively unstable results (therapeutic efficacy ending with treatment cessation), so the choice of optimal therapy is not straightforward...
April 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29339451/inhibition-of-5%C3%AE-reductase-alters-pregnane-metabolism-in-the-late-pregnant-mare
#15
Michelle A A Wynn, Barry A Ball, Erin Legacki, Alan Conley, Shavahn Loux, John May, Alejandro Esteller-Vico, Scott Stanley, Kirsten Scoggin, Edward Squires, Mats Troedsson
In the latter half of gestation in the mare, progesterone concentrations decline to near undetectable levels while other 5α-reduced pregnanes are elevated. Of these, 5α-dihydroprogesterone and allopregnanolone have been reported to have important roles in either pregnancy maintenance or fetal quiescence. During this time, the placenta is necessary for pregnane metabolism, with the enzyme 5α-reductase being required for the conversion of progesterone to 5α-dihydroprogesterone. The objectives of this study were to assess the effects of a 5α-reductase inhibitor, dutasteride on pregnane metabolism (pregnenolone, progesterone, 5α-dihydroprogesterone, 20α-hydroxy-5α-pregnan-3-one, 5α-pregnane-3β,20α-diol and allopregnanolone), to determine circulating dutasteride concentrations and to assess effects of dutasteride treatment on gestational parameters...
March 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29316005/tamsulosin-and-the-risk-of-dementia-in-older-men-with-benign-prostatic-hyperplasia
#16
Yinghui Duan, James J Grady, Peter C Albertsen, Z Helen Wu
PURPOSE: Clinicians use tamsulosin, an α1-adrenoceptor antagonist, to manage symptomatic benign prostatic hyperplasia (BPH). Because α1-adrenoceptors are also present in the brain, the potential exists for adverse effects on cognitive functions. We explored the association between tamsulosin use and dementia risk. METHODS: We used Medicare data (2006-2012) to conduct a cohort study among patients aged ≥65 years and diagnosed with BPH. Men taking tamsulosin (n = 253 136) were matched at a 1:1 ratio using propensity-scores to each of 6 comparison cohorts: patients who used no BPH-medication (n = 180 926), and patients who used the following alternative-BPH-medications: doxazosin (n = 28 581), terazosin (n = 23 858), alfuzosin (n = 17 934), dutasteride (n = 34 027), and finasteride (n = 38 767)...
March 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29283507/evaluation-of-bioequivalence-between-0-5-mg-dutasteride-capsules-manufactured-by-glaxosmithkline-and-an-existing-formulation-a-randomized-study-in-healthy-japanese-male-volunteers
#17
Hiroko Ino, Hiroshi Itoh, Yohei Doi, Harue Igarashi, Yotaro Numachi
No abstract text is available yet for this article.
March 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29280355/muscles-of-the-trunk-and-pelvis-are-responsive-to-testosterone-administration-data-from-testosterone-dose-response-study-in-young-healthy-men
#18
J Tapper, S Arver, K M Pencina, A Martling, L Blomqvist, C Buchli, Z Li, T Gagliano-Jucá, T G Travison, G Huang, T W Storer, S Bhasin, S Basaria
Testosterone dose-dependently increases appendicular muscle mass. However, the effects of testosterone administration on the core muscles of the trunk and the pelvis have not been evaluated. The present study evaluated the effects of testosterone administration on truncal and pelvic muscles in a dose-response trial. Participants were young healthy men aged 18-50 years participating in the 5α-Reductase (5aR) Trial. All participants received monthly injections of 7.5 mg leuprolide acetate to suppress endogenous testosterone production and weekly injections of 50, 125, 300, or 600 mg of testosterone enanthate and were randomized to receive either 2...
January 2018: Andrology
https://www.readbyqxmd.com/read/29224108/negative-impact-of-testosterone-deficiency-and-5%C3%AE-reductase-inhibitors-therapy-on-metabolic-and-sexual-function-in-men
#19
Abdulmaged M Traish
Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via aromatization into estradiol (E2 ) modulates important biochemical signaling pathways of human physiology and plays a critical role in the growth and/or maintenance of functions in a host of tissues and organs. T and 5α-DHT play an important role in regulating physiology of the muscle, adipose tissue, liver, bone, and central nervous system, as well as reproductive and sexual functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29203895/baseline-prostate-atrophy-is-associated-with-lower-tumor-volume-in-men-with-prostate-cancer-on-repeat-biopsy
#20
Daniel M Moreira, Gerald L Andriole, Ramiro Castro-Santamaria, Stephen J Freedland
BACKGROUND: Prostate atrophy (PA) is commonly identified in prostate biopsies. Previous studies suggest PA may be associated with lower PCa risk. However, it remains unclear whether PA is associated with smaller, less aggressive, and less advanced tumors. Thus, we sought to determine whether the presence and severity of baseline PA in men with initial biopsy negative for prostate cancer (PCa) is associated with PCa volume at 2- and 4-year repeat biopsy. METHODS: We performed a retrospective analysis of 927 men 50-75-years-old with negative baseline biopsy and positive 2- or 4-year repeat biopsy for PCa in the Reduction by Dutasteride of PCa Events study...
December 4, 2017: Prostate Cancer and Prostatic Diseases
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