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https://www.readbyqxmd.com/read/29447628/sexual-side-effects-of-5-%C3%AE-reductase-inhibitors-finasteride-and-dutasteride-a-comprehensive-review
#1
Raymond M Fertig, A Caresse Gamret, Evan Darwin, Sudeep Gaudi
The 5-α-reductase inhibitors finasteride and dutasteride are frequently used in the treatment of androgenetic alopecia and benign prostatichyperplasia. These drugs are effective at reducing levels of dihydrotestosterone, the primary androgen responsible for the pathogenesis of both these conditions. However, finasteride and dutasteride have also been shown to produce an increase in the incidence of sexual dysfunction, namely, impotence, decreased libido, and ejaculation disorder. The purpose of this study is to review the existing medical literature with regard to the sexual side effects of 5-α-reductase inhibitor therapy...
November 11, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29434054/influence-of-dutasteride-and-nifedipine-on-catsper-gene-expression-in-epididymis-of-mice
#2
Archana Srivastav, Bendangla Changkija, Kunal Sharan, Geet Kumar Nagar, Falgun Wanganuji Bansode
Calcium (Ca2+) signaling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility and the acrosome reaction are all mediated by increases in intracellular Ca2 + through CatSper (sperm specific cation channel). The CatSper channel complex contains four pore forming α subunits (CatSper1-4 ) and five accessory subunits called β, δ, ε, γ and ζ . Genetic deletion of any of the four CatSper genes in mice results in loss of hyperactivated motility and male infertility...
February 6, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29406237/a-68-year-old-man-with-chronic-myelogenous-leukemia-and-a-large-unilateral-pleural-effusion
#3
Adam Alter, Neal Chaisson, Sudipto Mukherjee, Thomas Gildea
A 68-year-old man with chronic myelogenous leukemia presents for evaluation of 2 months of dyspnea with exertion. He denies cough, fever, chest pain, weight gain, orthopnea, and edema. Since diagnosis of chronic myelogenous leukemia 5 years ago, he has been treated with dasatinib, with recent BCR-ABL1 assay showing no detectable disease in the peripheral blood. Medical history also includes hyperlipidemia, prostate enlargement, and hypothyroidism, but no prior heart or lung disease. Born in the Middle East, he immigrated to the United States 30 years ago and is working as a physician...
February 2018: Chest
https://www.readbyqxmd.com/read/29387405/effect-of-dutasteride-on-castration-resistant-prostate-cancer
#4
Takeshi Azuma, Yukihide Matayoshi, Yujiro Sato, Yasuhi Nagase
It has previously been demonstrated that the intratumoral generation of the potent androgen dihydrotestosterone (DHT), contributes critically to the progression of prostate cancer and its castration-resistant form, castration-resistant prostate cancer (CRPC). Circulating testosterone is converted into DHT by 5α-reductase (SRD5A). Dutasteride is a dual inhibitor of type I and II SRD5A. The present study assessed the effectiveness of dutasteride in the treatment of CRPC. Between 2010 and 2013, CRPC was diagnosed in 41 patients at the Tokyo Metropolitan Tama Medical Center...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29379733/the-use-of-5-alpha-reductase-inhibitors-in-the-treatment-of-benign-prostatic-hyperplasia
#5
REVIEW
Eric H Kim, John A Brockman, Gerald L Andriole
Benign prostatic hyperplasia (BPH) is characterized by an enlarged prostate, lower urinary tract symptoms (LUTS), and a decreased urinary flow rate. Common in older men, BPH is a progressive disease that can eventually lead to complications including acute urinary retention (AUR) and the need for BPH-related surgery. Both normal and abnormal prostate growth is driven by the androgen dihydrotestosterone (DHT), which is formed from testosterone under the influence of 5-alpha reductase. Thus, 5-alpha reductase inhibitors (5-ARIs) effectively reduce the serum and intraprostatic concentration of DHT, causing an involution of prostate tissue...
January 2018: Asian Journal of Urology
https://www.readbyqxmd.com/read/29368380/risk-of-rhabdomyolysis-from-5-%C3%AE-reductase-inhibitors
#6
Blayne Welk, Eric McArthur, Michael Ordon, Jade Dirk, Stephanie Dixon, Amit X Garg
PURPOSE: A recent regulatory warning and case reports have described the development of muscle complications with the use of 5-α reductase inhibitors (5ARIs). We wished to determine if there was a link between rhabdomyolysis and 5ARI usage. METHODS: We used a matched cohort design and linked administrative data from the province of Ontario, Canada, to investigate the risk of rhabdomyolysis in men using either finasteride or dutasteride. A total of 99 covariates were measured...
January 25, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29363345/androgenetic-alopecia-drug-safety-and-therapeutic-strategies
#7
Ion G Motofei, David L Rowland, Daniela L Baconi, Mircea Tampa, Maria-Isabela Sârbu, Stana Păunică, Vlad D Constantin, Cristian Bălălău, Ioana Păunică, Simona Roxana Georgescu
Androgenetic alopecia (AGA) is a benign condition with variable psychosocial impact, with some individuals adapting well while others needing therapeutic support. Although 5α-reductase inhibitors like finasteride and dutasteride have proven effective in ameliorating AGA, their use/selection is currently a subject of debate. Areas covered: Treatment of AGA with 5α-reductase inhibitors lead to variable adverse effects and relatively unstable results (therapeutic efficacy ending with treatment cessation), so the choice of optimal therapy is not straightforward...
January 24, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29339451/inhibition-of-5%C3%AE-reductase-alters-pregnane-metabolism-in-the-late-pregnant-mare
#8
Michelle Wynn, Barry A Ball, Erin Lea Legacki, Alan Conley, Shavahn Loux, John May, Alejandro Esteller-Vico, Scott D Stanley, Kirsten Scoggin, Edward L Squires, Mats Ht Troedsson
In the latter half of gestation in the mare, progesterone concentrations decline to near undetectable levels while other 5α-reduced pregnanes are elevated. Of these, 5α-dihydroprogesterone and allopregnanolone have been reported to have important roles in either pregnancy maintenance or fetal quiescence. During this time, the placenta is necessary for pregnane metabolism, with the enzyme 5α-reductase being required for the conversion of progesterone to 5α-dihydroprogesterone. The objectives of this study were to assess the effects of a 5α-reductase inhibitor, dutasteride, on pregnane metabolism (pregnenolone, progesterone, 5α-dihydroprogesterone, 20α-hydroxy-5α-pregnan-3-one, 5α-pregnane-3β,20α-diol, and allopregnanolone), to determine circulating dutasteride concentrations, and to assess effects of dutasteride treatment on gestational parameters...
January 16, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29316005/tamsulosin-and-the-risk-of-dementia-in-older-men-with-benign-prostatic-hyperplasia
#9
Yinghui Duan, James J Grady, Peter C Albertsen, Z Helen Wu
PURPOSE: Clinicians use tamsulosin, an α1-adrenoceptor antagonist, to manage symptomatic benign prostatic hyperplasia (BPH). Because α1-adrenoceptors are also present in the brain, the potential exists for adverse effects on cognitive functions. We explored the association between tamsulosin use and dementia risk. METHODS: We used Medicare data (2006-2012) to conduct a cohort study among patients aged ≥65 years and diagnosed with BPH. Men taking tamsulosin (n = 253 136) were matched at a 1:1 ratio using propensity-scores to each of 6 comparison cohorts: patients who used no BPH-medication (n = 180 926), and patients who used the following alternative-BPH-medications: doxazosin (n = 28 581), terazosin (n = 23 858), alfuzosin (n = 17 934), dutasteride (n = 34 027), and finasteride (n = 38 767)...
January 9, 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29283507/evaluation-of-bioequivalence-between-0-5-mg-dutasteride-capsules-manufactured-by-glaxosmithkline-and-an-existing-formulation-a-randomized-study-in-healthy-japanese-male-volunteers
#10
Hiroko Ino, Hiroshi Itoh, Yohei Doi, Harue Igarashi, Yotaro Numachi
No abstract text is available yet for this article.
December 28, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29280355/muscles-of-the-trunk-and-pelvis-are-responsive-to-testosterone-administration-data-from-testosterone-dose-response-study-in-young-healthy-men
#11
J Tapper, S Arver, K M Pencina, A Martling, L Blomqvist, C Buchli, Z Li, T Gagliano-Jucá, T G Travison, G Huang, T W Storer, S Bhasin, S Basaria
Testosterone dose-dependently increases appendicular muscle mass. However, the effects of testosterone administration on the core muscles of the trunk and the pelvis have not been evaluated. The present study evaluated the effects of testosterone administration on truncal and pelvic muscles in a dose-response trial. Participants were young healthy men aged 18-50 years participating in the 5α-Reductase (5aR) Trial. All participants received monthly injections of 7.5 mg leuprolide acetate to suppress endogenous testosterone production and weekly injections of 50, 125, 300, or 600 mg of testosterone enanthate and were randomized to receive either 2...
January 2018: Andrology
https://www.readbyqxmd.com/read/29224108/negative-impact-of-testosterone-deficiency-and-5%C3%AE-reductase-inhibitors-therapy-on-metabolic-and-sexual-function-in-men
#12
Abdulmaged M Traish
Androgens are steroid hormones with pleotropic and diverse biochemical and physiological functions, and androgen deficiency exerts a negative impact on human health. Testosterone (T) either directly or via its transformation into the more potent metabolite 5α-dihydrotestosterone (5α-DHT) or via aromatization into estradiol (E2) modulates important biochemical signaling pathways of human physiology and plays a critical role in the growth and/or maintenance of functions in a host of tissues and organs. T and 5α-DHT play an important role in regulating physiology of the muscle, adipose tissue, liver, bone, and central nervous system, as well as reproductive and sexual functions...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29203895/baseline-prostate-atrophy-is-associated-with-lower-tumor-volume-in-men-with-prostate-cancer-on-repeat-biopsy
#13
Daniel M Moreira, Gerald L Andriole, Ramiro Castro-Santamaria, Stephen J Freedland
BACKGROUND: Prostate atrophy (PA) is commonly identified in prostate biopsies. Previous studies suggest PA may be associated with lower PCa risk. However, it remains unclear whether PA is associated with smaller, less aggressive, and less advanced tumors. Thus, we sought to determine whether the presence and severity of baseline PA in men with initial biopsy negative for prostate cancer (PCa) is associated with PCa volume at 2- and 4-year repeat biopsy. METHODS: We performed a retrospective analysis of 927 men 50-75-years-old with negative baseline biopsy and positive 2- or 4-year repeat biopsy for PCa in the Reduction by Dutasteride of PCa Events study...
December 4, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29194783/assessing-dutasteride-associated-sexual-dysfunction-using-the-u-s-food-and-drug-administration-adverse-event-reporting-system-faers
#14
Aditya K Gupta, Jessie Carviel, Madhulika A Gupta, Neil H Shear
BACKGROUND: Incidences of sexual dysfunction due to the use of 5 α-reductase inhibitors have been suggested. Despite low sexual dysfunction reported in clinical trials, an analysis of the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) database revealed a significant disproportionality in the reporting of sexual dysfunction with the use of finasteride. Therefore, it is likely that a similar relationship with dutasteride may exist. OBJECTIVE: To determine whether dutasteride use leads to a higher risk of sexual dysfunction compared to a baseline risk for all other drugs using the FAERS database...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29194687/serum-free-complete-medium-an-alternative-medium-to-mimic-androgen-deprivation-in-human-prostate-cancer-cell-line-models
#15
Michael V Fiandalo, John H Wilton, Krystin M Mantione, Carol Wrzosek, Kristopher M Attwood, Yue Wu, James L Mohler
BACKGROUND: Almost all men who present with advanced prostate cancer (CaP) and some men who fail therapy for clinically localized CaP are treated with androgen deprivation therapy (ADT). CaP cell lines are used to identify and characterize new agents for ADT or investigate mechanisms of ADT resistance. CaP cell lines are maintained in culture medium that contains fetal bovine serum, which contains testosterone (T). Androgen deprivation experiments are performed using media supplemented with androgen-free serum, such as charcoal stripped fetal bovine serum (CS-FBS)...
February 2018: Prostate
https://www.readbyqxmd.com/read/29161905/a-focused-review-on-the-effects-of-preoperative-5%C3%AE-reductase-inhibitors-treatment-in-patients-undergoing-holmium-laser-enucleation-of-the-prostate-what-do-we-know-so-far
#16
Panagiotis Dimopoulos, Panagiotis Christopoulos, Spyridon Kampantais
INTRODUCTION: The effects of medical therapy with finasteride or dutasteride during transurethral enucleation of prostate and tissue morcellation are not well defined. In theory, the risk of prostatic fibrosis versus the potential benefit of reduced intraoperative bleeding have been addressed as potential competing factors. The aim of this review was to provide evidence if 5a-reductase inhibitors put the surgeon at a disadvantage or impacts on patient outcomes. MATERIAL AND METHODS: We performed a literature search of PubMed, Scopus and Web of science databases...
November 22, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29156456/impact-of-truncated-area-on-point-estimate-and-intra-subject-variability-in-bioequivalence-of-dutasteride-with-long-half-life
#17
Budi Prasaja, Yahdiana Harahap, Windy Lusthom, Lia Yumi, Anna Sofiana, Monica Sandra, Falah Safira, Uci Chilmi
Purpose To investigate the effect of using truncated area under the curve (AUC0-72) on bioequivalence of dutasteride with long half-life in point estimate and intra-subject variability. Methods Fifteen subjects were enrolled in this single-dose, open-label, randomized two-way crossover design following an overnight fasting with five-week washout period. Plasma samples were collected to 72 h and 144 h following drug administration and dutasteride were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods...
November 20, 2017: Drug Research
https://www.readbyqxmd.com/read/29150830/does-preoperative-use-of-dutasteride-decrease-bleeding-during-open-prostatectomy
#18
Arif Demirbas, Berkan Resorlu, Murat Tolga Gulpinar, Sina Kardas, Omer Gokhan Doluoglu, Abdulkadir Tepeler, Muhammet Fatih Kilinc, Tolga Karakan, Serkan Ozcan
PURPOSE: To investigate whether use of dutasteride, a 5-alpha reductase inhibitor, for at least four weeks preoperatively affected the blood loss during open prostatectomy (OP). MATERIALS AND METHODS: Retrospective analysis was made of the data of 110 patients who had undergone OP. Group I comprised 50 patients that used dutasteride for 4 weeks preoperatively, and Group II comprised 60 patients that did not use the drug. The groups were compared in respect of age, total prostate specific antigen (TPSA) levels, prostate volumes, preoperative hemoglobin (Hgb) and hematocrit (Hct) levels, postoperative reduction of Hgb and Hct, percentage reduction in Hgb and Hct, and the administration of postoperative blood products...
November 15, 2017: Urology Journal
https://www.readbyqxmd.com/read/29143575/determination-of-illegal-adulteration-of-dietary-supplements-with-synthetic-hair-growth-compounds-by-uplc-and-lc-q-tof-ms
#19
Ji Hyun Lee, Gihaeng Kang, Han Na Park, Jihee Kim, Nam Sook Kim, Seongsoo Park, Sung-Kwan Park, Sun Young Baek, Hoil Kang
In this study, we developed a UPLC-PDA and LC-Q-TOF/MS method to identify and measure the following prohibited substances that may be found in dietary supplements:triaminodil, minoxidil, bimatoprost, alimemazine, diphenylcyclopropenone, α-tradiol, finasteride, methyltestosterone, spironolatone, flutamide, cyproterone, dutasteride, and testosterone 17-propionate.The method was validated according to International Conference on Harmonization guidelines in terms of specificity, linearity, accuracy, precision, LOD, LOQ, recovery, and stability...
December 14, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29135073/prostate-cancer-detection-using-quantitative-t2-and-t2-weighted-imaging-the-effects-of-5-alpha-reductase-inhibitors-in-men-on-active-surveillance
#20
Francesco Giganti, Giulio Gambarota, Caroline M Moore, Nicola L Robertson, Neil McCartan, Charles Jameson, Simon R J Bott, Mathias Winkler, Brandon Whitcher, Ramiro Castro-Santamaria, Mark Emberton, Clare Allen, Alex Kirkham
BACKGROUND: T2 -weighted imaging (T2 -WI) information has been used in a qualitative manner in the assessment of prostate cancer. Quantitative derivatives (T2 relaxation time) can be generated from T2 -WI. These outputs may be useful in helping to discriminate clinically significant prostate cancer from background signal. PURPOSE/HYPOTHESIS: To investigate changes in quantitative T2 parameters in lesions and noncancerous tissue of men on active surveillance for prostate cancer taking dutasteride 0...
November 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
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