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https://www.readbyqxmd.com/read/28433605/stability-of-patient-specific-features-of-altered-dna-replication-timing-in-xenografts-of-primary-human-acute-lymphoblastic-leukemia
#1
Takayo Sasaki, Juan Carlos Rivera-Mulia, Daniel Vera, Jared Zimmerman, Sunny Das, Michelle Padget, Naoto Nakamichi, Bill H Chang, Jeff Tyner, Brian J Druker, Andrew P Weng, Curt I Civin, Connie J Eaves, David M Gilbert
Genome-wide DNA replication timing (RT) profiles reflect the global 3D chromosome architecture of cells. They also provide a comprehensive and unique megabase-scale picture of the cellular epigenetic state. Thus normal differentiation involves reproducible changes in RT and transformation generally perturbs these, although the potential effects of altered RT on the properties of transformed cells remain largely unknown. A major challenge to interrogating these issues in human acute lymphoid leukemia (ALL) is the low proliferative activity of most of the cells, which may be further reduced in cryopreserved samples and difficult to overcome in vitro...
April 19, 2017: Experimental Hematology
https://www.readbyqxmd.com/read/28433453/attending-documentation-contribution-to-billing-at-an-academic-emergency-department-with-an-electronic-health-record
#2
Brian J Yun, Stephen C Dorner, Brian M Baccari, John Brennan, Karen Smith, Ali S Raja, Benjamin A White
INTRODUCTION: In emergency medicine (EM), patient care documentation serves many functions, including supporting reimbursement. In addition, many electronic health record systems facilitate automatically populating certain data fields. As a result, in the academic model, the attending's note may now more often recapitulate many of the same elements found in the resident's or physician assistant's (PA) note. We sought to determine the value of additional attending documentation, and how often the attending documentation prevented a downcoding event...
April 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28433260/future-and-potential-spending-on-health-2015-40-development-assistance-for-health-and-government-prepaid-private-and-out-of-pocket-health-spending-in-184-countries
#3
(no author information available yet)
BACKGROUND: The amount of resources, particularly prepaid resources, available for health can affect access to health care and health outcomes. Although health spending tends to increase with economic development, tremendous variation exists among health financing systems. Estimates of future spending can be beneficial for policy makers and planners, and can identify financing gaps. In this study, we estimate future gross domestic product (GDP), all-sector government spending, and health spending disaggregated by source, and we compare expected future spending to potential future spending...
April 19, 2017: Lancet
https://www.readbyqxmd.com/read/28433256/evolution-and-patterns-of-global-health-financing-1995-2014-development-assistance-for-health-and-government-prepaid-private-and-out-of-pocket-health-spending-in-184-countries
#4
(no author information available yet)
BACKGROUND: An adequate amount of prepaid resources for health is important to ensure access to health services and for the pursuit of universal health coverage. Previous studies on global health financing have described the relationship between economic development and health financing. In this study, we further explore global health financing trends and examine how the sources of funds used, types of services purchased, and development assistance for health disbursed change with economic development...
April 19, 2017: Lancet
https://www.readbyqxmd.com/read/28433016/first-principles-c-band-absorption-spectra-of-so2-and-its-isotopologues
#5
Bin Jiang, Praveen Kumar, Jacek Kłos, Millard H Alexander, Bill Poirier, Hua Guo
The low-energy wing of the C∼B21←X∼(1)A1 absorption spectra for SO2 in the ultraviolet region is computed for the 32S,(33)S,(34)S and (36)S isotopes, using the recently developed ab initio potential energy surfaces (PESs) of the two electronic states and the corresponding transition dipole surface. The state-resolved absorption spectra from various ro-vibrational states of SO2(X∼(1)A1) are computed. When contributions of these excited ro-vibrational states are included, the thermally averaged spectra are broadened but maintain their key characters...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28431536/-popping-nana-back-into-bed-a-qualitative-exploration-of-paramedic-decision-making-when-caring-for-older-people-who-have-fallen
#6
Paul Simpson, Ric Thomas, Jason Bendall, Bill Lord, Stephen Lord, Jacqueline Close
BACKGROUND: Older fallers constitute a large proportion of ambulance work, and as many as 25% are not transported to hospital following paramedic assessment. The objective of this study was to explore the decision making process used by paramedics when caring for older fallers. METHODS: A qualitative study was conducted using constructivist grounded theory methodology. Purposive sampling was used to recruit paramedics to participate in semi-structured interviews and focus groups...
April 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28430692/lack-of-association-between-the-use-of-nerve-blockade-and-the-risk-of-postoperative-chronic-opioid-use-among-patients-undergoing-total-knee-arthroplasty-evidence-from-the-marketscan-database
#7
Eric C Sun, Brian T Bateman, Stavros G Memtsoudis, Mark D Neuman, Edward R Mariano, Laurence C Baker
BACKGROUND: Total knee arthroplasty (TKA) is associated with high rates of prolonged opioid use after surgery (10%-34%). By decreasing opioid use in the immediate postoperative period, perioperative nerve blockade has been hypothesized to decrease the risk of persistent opioid use. METHODS: Using health care utilization data, we constructed a sample of 120,080 patients undergoing TKA between 2002 and 2012 and used billing data to identify the utilization of peripheral or neuraxial blockade...
April 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28430120/autonomous-multi-robot-search-for-a-hazardous-source-in-a-turbulent-environment
#8
Branko Ristic, Daniel Angley, Bill Moran, Jennifer L Palmer
Finding the source of an accidental or deliberate release of a toxic substance into the atmosphere is of great importance for national security. The paper presents a search algorithm for turbulent environments which falls into the class of cognitive (infotaxi) algorithms. Bayesian estimation of the source parameter vector is carried out using the Rao-Blackwell dimension-reduction method, while the robots are controlled autonomously to move in a scalable formation. Estimation and control are carried out in a centralised replicated fusion architecture assuming all-to-all communication...
April 21, 2017: Sensors
https://www.readbyqxmd.com/read/28429891/comparison-of-immunization-rates-of-adults-ages-65-years-and-older-managed-within-two-nurse-practitioner-owned-clinics-with-national-immunization-rates
#9
Wendy L Wright, Elise Morrell, Jennie Lee, Norma Graciela Cuellar, Patricia White
BACKGROUND AND PURPOSE: Adults ages ≥65 years are at increased risk for infectious diseases. Ensuring these individuals are fully vaccinated is imperative. The purpose of this study was to assess the immunization rates of adults ages ≥65 years managed by nurse practitioners (NPs) and compare the results with national immunization rates and Healthy People 2020 goals. METHODS: A convenience sample of adults ages ≥65 years was obtained from two NP-managed clinics...
April 21, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28426795/properties-of-healthcare-teaming-networks-as-a-function-of-network-construction-algorithms
#10
Martin S Zand, Melissa Trayhan, Samir A Farooq, Christopher Fucile, Gourab Ghoshal, Robert J White, Caroline M Quill, Alexander Rosenberg, Hugo Serrano Barbosa, Kristen Bush, Hassan Chafi, Timothy Boudreau
Network models of healthcare systems can be used to examine how providers collaborate, communicate, refer patients to each other, and to map how patients traverse the network of providers. Most healthcare service network models have been constructed from patient claims data, using billing claims to link a patient with a specific provider in time. The data sets can be quite large (106-108 individual claims per year), making standard methods for network construction computationally challenging and thus requiring the use of alternate construction algorithms...
2017: PloS One
https://www.readbyqxmd.com/read/28426319/the-monetary-cost-of-sexual-assault-to-privately-insured-us-women-in-2013
#11
Ashley M Tennessee, Tamala S Bradham, Brandi M White, Kit N Simpson
OBJECTIVES: To determine whether privately insured female rape victims were billed for charges associated with a specific rape in the United States. METHODS: We examined 2013 de-identified patient data from Truven Analytics Health MarketScan database for an assault that occurred by using International Classification of Diseases, Ninth Revision, code E960.1. RESULTS: Analysis of insurance providers' payment patterns for 1355 incident events to female victims aged between 16 and 61 years revealed that victims remit, on average, 14% or $948 of the rape cost, whereas insurance providers pay 86% or $5789 of the total cost...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28426255/pregabalin-for-the-treatment-of-neuropathic-pain-a-narrative-review-for-primary-care-providers
#12
Yvonne D'Arcy, Bill McCarberg, Bruce Parsons, Regina Behar, Andrew Thorpe, Andrea Alexander
Neuropathic pain (NeP) is a distinct type of pain caused by damage to the nervous system itself. This often severe and chronic type of pain requires specific treatments that target the underlying pain pathophysiology. The purpose of the current narrative review is to provide an overview of pregabalin (Lyrica®) for the treatment of NeP including its effects on pain, pain-related sleep interference, and other health-related outcomes, timing of therapeutic effect, safety and tolerability, and dosing. The information provided here, along with that in our companion review [1], will help primary care providers develop more effective NeP treatment strategies...
April 20, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28425921/plasma-micro-rna-alterations-appear-late-in-pancreatic-cancer
#13
Oskar Franklin, Pär Jonsson, Ola Billing, Erik Lundberg, Daniel Öhlund, Hanna Nyström, Christina Lundin, Henrik Antti, Malin Sund
OBJECTIVES: The aim of this research was to study whether plasma microRNAs (miRNA) can be used for early detection of pancreatic cancer (PC) by analyzing prediagnostic plasma samples collected before a PC diagnosis. BACKGROUND: PC has a poor prognosis due to late presenting symptoms and early metastasis. Circulating miRNAs are altered in PC at diagnosis but have not been evaluated in a prediagnostic setting. METHODS: We first performed an initial screen using a panel of 372 miRNAs in a retrospective case-control cohort that included early-stage PC patients and healthy controls...
January 3, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28425029/comparison-of-a-novel-formulation-of-abiraterone-acetate-vs-the-originator-formulation-in-healthy-male-subjects-two-randomized-open-label-crossover-studies
#14
Ronald Goldwater, Azra Hussaini, Bill Bosch, Paul Nemeth
BACKGROUND AND OBJECTIVE: Abiraterone acetate is approved for the treatment of metastatic castration-resistant prostate cancer. The originator abiraterone acetate (OAA) formulation is poorly absorbed and exhibits large pharmacokinetic variability in abiraterone exposure. Abiraterone acetate fine particle (AAFP) is a proprietary formulation (using SoluMatrix Fine Particle Technology™) designed to increase the oral bioavailability of abiraterone acetate. Here, we report on two phase I studies in healthy male subjects aged 18-50 years...
April 19, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28424849/ultrasound-evaluation-of-the-ulnar-collateral-ligament-of-the-elbow-which-method-is-most-reproducible
#15
Mehool Shukla, Robert Keller, Nathan Marshall, Hafeez Ahmed, Courtney Scher, Vasilios Bill Moutzouros, Marnix van Holsbeeck
INTRODUCTION: The ulnar collateral ligament (UCL) is an important medial stabilizer of the elbow, particularly in overhead-throwing athletes. However, there is no universally accepted method for evaluating UCL thickness with ultrasound (US). OBJECTIVE: To assess reproducibility of previously published methods, as well as a modified technique, for evaluating the UCL via US. We hypothesize that a modified technique would show greater reproducibility. MATERIAL AND METHODS: Using US, the thickness of the UCL in 50 volunteers was measured by two musculoskeletal trained radiologists using two different measurement techniques...
April 20, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28422530/physiological-changes-following-competition-in-male-and-female-physique-athletes-a-pilot-study
#16
Eric T Trexler, Katie R Hirsch, Bill I Campbell, Abbie E Smith-Ryan
The purpose of the current study was to evaluate changes in body composition, metabolic rate, and hormones during post-competition recovery. Data were collected from natural physique athletes (7 male/8 female) within one week before (T1) competition, within one week after (T2), and 4-6 weeks after (T3) competition. Measures included body composition (fat mass [FM] and lean mass [LM] from ultrasongraphy), resting metabolic rate (RMR; indirect calorimetry), and salivary leptin, testosterone, cortisol, ghrelin, and insulin...
April 19, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28422517/neuropathic-pain-a-narrative-review-of-etiology-assessment-diagnosis-and-treatment-for-primary-care-providers
#17
Bill McCarberg, Yvonne D'Arcy, Bruce Parsons, Alesia Sadosky, Andrew Thorpe, Regina Behar
Neuropathic pain (NeP) is a distinct type of chronic pain that is a direct result of damage to the nervous system itself. Studies have shown that training on the topic of chronic pain in medical schools is lacking and many practitioners are not confident in their ability to effectively manage patients with such pain. The purpose of this narrative review is to provide a brief high-level overview of NeP for primary healthcare providers that includes a discussion of mechanisms, prevalence, burden, assessment, and treatment...
April 19, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28421938/agency-nursing-goes-paye
#18
Alison Moore
Many agency nurses bill for their services through a limited or personal services company. In the past, this has reduced the tax they need to pay, allowing some profits to be taken as dividends. It has also allowed them to offset costs, such as travel, against their profits.
April 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28420595/using-an-array-of-implementation-strategies-to-improve-success-rates-of-pharmacist-initiated-medication-therapy-management-services-in-community-pharmacies
#19
Rachel Stafford, Jeremy Thomas, Nalin Payakachat, Tiffany Diemer, Michele Lang, Brooke Kordsmeier, Geoffrey Curran
BACKGROUND: With the introduction of the Centers for Medicare and Medicaid Services Stars Measure program has come a greater expectation of Medication Therapy Management (MTM) services from community pharmacies. To meet the growing demand of these services, pharmacies have sought out various methods of engaging pharmacists to provide MTM. Barriers for completing MTM include inadequate time to complete the services, insufficient staffing, lack of sufficient compensation, billing difficulty, lack of interest among patients (including refusing MTM services when offered), inadequate training/experience, and lack of support from management...
April 8, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28420401/using-media-to-impact-health-policy-making-an-integrative-systematic-review
#20
REVIEW
Lama Bou-Karroum, Fadi El-Jardali, Nour Hemadi, Yasmine Faraj, Utkarsh Ojha, Maher Shahrour, Andrea Darzi, Maha Ali, Carine Doumit, Etienne V Langlois, Jad Melki, Gladys Honein AbouHaidar, Elie A Akl
INTRODUCTION: Media interventions can potentially play a major role in influencing health policies. This integrative systematic review aimed to assess the effects of planned media interventions-including social media-on the health policy-making process. METHODS: Eligible study designs included randomized and non-randomized designs, economic studies, process evaluation studies, stakeholder analyses, qualitative methods, and case studies. We electronically searched Medline, EMBASE, Communication and Mass Media Complete, Cochrane Central Register of Controlled Trials, and the WHO Global Health Library...
April 18, 2017: Implementation Science: IS
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