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https://www.readbyqxmd.com/read/28821637/ensuring-due-process-in-the-iacuc-and-animal-welfare-setting-considerations-in-developing-noncompliance-policies-and-procedures-for-institutional-animal-care-and-use-committees-and-institutional-officials
#1
REVIEW
Barbara C Hansen, Sylvia Gografe, Stacy Pritt, Kai-Lin Catherine Jen, Camille A McWhirter, Susan M Barman, Anthony Comuzzie, Molly Greene, Justin A McNulty, Daniel Eugene Michele, Naz Moaddab, Randall J Nelson, Karen Norris, Karen D Uray, Ron Banks, Karin N Westlund, Bill J Yates, Jerald Silverman, Kenneth D Hansen, Barbara Redman
Every institution that is involved in research with animals is expected to have in place policies and procedures for the management of allegations of noncompliance with the Animal Welfare Act and the U.S. Public Health Service Policy on the Humane Care and Use of Laboratory Animals. We present here a model set of recommendations for institutional animal care and use committees and institutional officials to ensure appropriate consideration of allegations of noncompliance with federal Animal Welfare Act regulations that carry a significant risk or specific threat to animal welfare...
August 15, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28821481/inguinal-canal-spermatic-cord-leiomyoma-presenting-as-an-incarcerated-inguinal-hernia
#2
Marijan Koprivanac, Steven D Billings, Vadim Khachaturov, Gareth Morris-Stiff
Leiomyoma is a benign neoplasm originating from smooth muscle cells and is most commonly seen in the uterus, followed by the small bowel and oesophagus. We report a rare case of a 41-year-old male patient with a spermatic cord leiomyoma that presented as an inguinal canal mass mimicking an irreducible inguinal hernia without scrotal involvement. This report highlights the rare presentation and workup of an inguinal mass, importance of intraoperative decision making based on operative findings and the significance of postoperative pathology findings...
August 17, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28821010/willingness-to-pay-for-safe-drinking-water-a-contingent-valuation-study-in-jacksonville-fl
#3
Chiradip Chatterjee, Russell Triplett, Christopher K Johnson, Parvez Ahmed
A surprising number of U.S. cities have drinking water with unhealthy levels of chemicals and contaminants. The city of Jacksonville (Florida), the location for this study, owns the dubious distinction of being ranked among the worst major American cities in water quality according to water quality tests conducted between 2005 and 2009 by the Environmental Working Group (EWG). This report of toxic chemicals in the Jacksonville water supply generated considerable negative publicity and coincides with a frequent and common complaint among residents of foul-smelling water...
August 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28820337/paper-title-circular-rnas-isolation-characterisation-and-their-potential-role-in-diseases
#4
Lumei Liu, Jian Wang, Ramin Khanabdali, Bill Kalionis, Xiantao Tai, Shijin Xia
Circular RNA (circRNA) generated by alternative splicing represents a special class of non-coding RNA molecule. CircRNAs are abundant in the eukaryotic cell cytoplasm and have a characteristic organization, timing of action and disease specificity. In contrast to linear RNA, circRNAs are resistant to RNA exonuclease. Consequently, circRNA escapes normal RNA turnover and this improves circRNA stability. CircRNAs can be degraded by microRNA (miRNA) and this results in linearization of the circRNA, which can then act as competitor to endogenous RNA...
August 18, 2017: RNA Biology
https://www.readbyqxmd.com/read/28818661/variation-in-organochlorine-and-mercury-levels-in-first-and-replacement-eggs-of-a-single-egg-clutch-breeder-the-thick-billed-murre-at-a-breeding-colony-in-the-canadian-arctic
#5
Birgit M Braune, Shoshanah R Jacobs, Anthony J Gaston
Contaminant concentrations may vary among sequentially-laid eggs in multi-egg clutches, and this variation has implications for the interpretation of contaminant concentrations in monitoring programs. The thick-billed murre (Uria lomvia) is a key species for monitoring contaminants in the Canadian Arctic and lays only a single egg per year. Therefore, the potential issue of intra-clutch variation in contaminant concentrations is avoided. However, if the egg is removed or lost early in the incubation stage, the adult female murre will relay...
August 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28817372/financial-burden-in-survivors-of-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study
#6
Ryan D Nipp, Anne C Kirchhoff, Douglas Fair, Julia Rabin, Kelly A Hyland, Karen Kuhlthau, Giselle K Perez, Leslie L Robison, Gregory T Armstrong, Paul C Nathan, Kevin C Oeffinger, Wendy M Leisenring, Elyse R Park
Purpose Survivors of childhood cancer may experience financial burden as a result of health care costs, particularly because these patients often require long-term medical care. We sought to evaluate the prevalence of financial burden and identify associations between a higher percentage of income spent on out-of-pocket medical costs (≥ 10% of annual income) and issues related to financial burden (jeopardizing care or changing lifestyle) among survivors of childhood cancer and a sibling comparison group. Methods Between May 2011 and April 2012, we surveyed an age-stratified, random sample of survivors of childhood cancer and a sibling comparison group who were enrolled in the Childhood Cancer Survivor Study...
August 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28816101/measurement-of-total-hemoglobin-reduces-red-cell-transfusion-in-hospitalized-patients-undergoing-cardiac-surgery-a-retrospective-database-analysis
#7
Christopher Craver, Kathy W Belk, Gerard J Myers
INTRODUCTION: Historically, perioperative hemoglobin monitoring has relied on calculated saturation, using blood gas devices that measure plasma hematocrit (Hct). Co-oximetry, which measures total hemoglobin (tHb), yields a more comprehensive assessment of hemodilution. The purpose of this study was to examine the association of tHb measurement by co-oximetry and Hct, using conductivity with red blood cell (RBC) transfusion, length of stay (LOS) and inpatient costs in patients having major cardiac surgery...
August 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28815912/assembly-and-rna-free-annotation-of-highly-heterozygous-genomes-the-case-of-the-thick-billed-murre-uria-lomvia
#8
Anna Tigano, Timothy B Sackton, Vicki L Friesen
Thanks to a dramatic reduction in sequencing costs followed by a rapid development of bioinformatics tools, genome assembly and annotation have become accessible to many researchers in recent years. Among tetrapods, birds have genomes that display many features that facilitate their assembly and annotation, such as small genome size, low number of repeats, and highly conserved genomic structure. However, we found that high genomic heterozygosity could have a great impact on the quality of the genome assembly of the thick-billed murre (Uria lomvia), an arctic colonial seabird...
August 16, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28815350/already-at-the-table-patterns-of-play-and-gambling-involvement-prior-to-gambling-expansion
#9
Sarah E Nelson, Debi A LaPlante, Heather M Gray, Matthew A Tom, John H Kleschinsky, Howard J Shaffer
During 2011, the Governor of Massachusetts signed a bill to allow casino gambling in the state (Commonwealth of Massachusetts 2011). As a result, two resort casinos will begin operations during 2018 and 2019; a smaller slots parlor began operations during June 2015. Prior to this expansion, gambling was widely available in Massachusetts, through the state lottery, off-track betting, and gambling opportunities available in neighboring states. Within this context, it is important to understand the patterns of gambling involvement in the population prior to gambling expansion...
August 16, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28815131/integrating-medication-alert-data-into-a-clinical-data-repository-to-enable-retrospective-study-of-drug-interaction-alerts-in-clinical-practice
#10
Mei Liu, Brittany L Melton, Gregory Ator, Lemuel R Waitman
Current clinical data repositories primarily extract data from multiple administrative and electronic medical record (EMR) data resources (e.g., hospital and physician billing records) containing specific patient-level data including demographics, medications, laboratory results, diagnoses, and procedure codes. It overlooks the importance of EMR system-level data (e.g., medication alerts that are routinely used by physicians, nurses, and pharmacists for decision support) for the surveillance of EMR decision support tools...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28815116/reducing-clinical-noise-for-body-mass-index-measures-due-to-unit-and-transcription-errors-in-the-electronic-health-record
#11
Robert Goodloe, Eric Farber-Eger, Jonathan Boston, Dana C Crawford, William S Bush
Body mass index (BMI) is an important outcome and covariate adjustment for many clinical association studies. Accurate assessment of BMI, therefore, is a critical part of many study designs. Electronic health records (EHRs) are a growing source of clinical data for research purposes, and have proven useful for identifying and replicating genetic associations. EHR-based data collected for clinical and billing purposes have several unique properties, including a high degree of heterogeneity or "clinical noise...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28814947/preserving-the-anti-scientific-linear-no-threshold-myth-authority-agnosticism-transparency-and-the-standard-of-care
#12
Bill Sacks, Jeffry A Siegel
The linear no-threshold (LNT) assumption is over 70 years old and holds that all ionizing radiation exposure leaves cumulative effects, all of which are harmful regardless of how low the dose or dose rate is. The claimed harm centers on the risk of future radiogenic cancer. This has been shown countless times to be fallacious, and hundreds of scientific studies-both experimental and observational/epidemiological-demonstrate that at low enough doses and dose rates, ionizing radiation stimulates an evolved adaptive response and therefore is beneficial to health, lowering rather than raising the risk of cancer...
July 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28814724/pathogenic-bacteria-enhance-dispersal-through-alteration-of-drosophila-social-communication
#13
Ian W Keesey, Sarah Koerte, Mohammed A Khallaf, Tom Retzke, Aurélien Guillou, Ewald Grosse-Wilde, Nicolas Buchon, Markus Knaden, Bill S Hansson
Pathogens and parasites can manipulate their hosts to optimize their own fitness. For instance, bacterial pathogens have been shown to affect their host plants' volatile and non-volatile metabolites, which results in increased attraction of insect vectors to the plant, and, hence, to increased pathogen dispersal. Behavioral manipulation by parasites has also been shown for mice, snails and zebrafish as well as for insects. Here we show that infection by pathogenic bacteria alters the social communication system of Drosophila melanogaster...
August 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28814607/early-career-researchers-an-interview-with-graham-scott
#14
(no author information available yet)
Graham Scott is an Assistant Professor at McMaster University, Canada, where he studies the integrative biology of how animals cope in challenging environments. He received his Bachelor's degree in biology before completing a Master's degree with Trish Schulte and then a PhD in 2009 with Bill Milsom at the University of British Columbia, Canada. He moved on to continue his postdoc training with Ian Johnston at the University of St Andrews, UK. Scott received the Animal Section Presidents' Medal from the Society for Experimental Biology in 2012, he was an author on the Journal of Zoology Paper of the Year in 2015 and he was awarded the Robert G...
August 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28813158/continuous-flow-synthesis-of-morpholines-and-oxazepanes-with-silicon-amine-protocol-slap-reagents-and-lewis-acid-facilitated-photoredox-catalysis
#15
Moritz K Jackl, Luca Legnani, Bill Morandi, Jeffrey W Bode
Photocatalytic coupling of aldehydes and silicon amine protocol (SLAP) reagents enables the simple, scalable synthesis of substituted morpholines, oxazepanes, thiomorpholines, and thiazepanes under continuous flow conditions. Key to the success of this process is the combination of an inexpensive organic photocatalyst (TPP) and a Lewis acid additive, which form an amine radical cation that is easily reduced to complete the catalytic cycle. Di- and trisubstituted SLAP reagents are formed in one step by an iron-catalyzed aminoetherification of olefins...
August 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/28812864/billing-for-intravenous-hydration
#16
Cindy Hughes
No abstract text is available yet for this article.
July 2017: Family Practice Management
https://www.readbyqxmd.com/read/28812282/implementation-of-an-integrated-care-learning-experience-within-the-psychiatry-clerkship-nutrition-education-of-patients-with-serious-mental-illness
#17
Shinnyi Chou, Dana Raml, Ryan Hafner, Bill Baerentzen, Sharon Hammer
No abstract text is available yet for this article.
August 15, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28811580/%C3%AE-eta-2-glycoprotein-i-protects-mice-against-gram-negative-septicaemia-in-a-sexually-dimorphic-manner
#18
Fatima El-Assaad, Miao Qi, Alice Kizny Gordon, Jian Qi, Shangwen Dong, Freda Passam, James Crofton Weaver, Bill Giannakopoulos, Steven Anthony Krilis
The immune responses of males and females to bacterial infections display differences. The mechanisms that underlie this sexual dimorphism are multifactorial. Lipopolysaccharide (LPS) contributes to the pathogenesis of endotoxaemia. We have previously demonstrated that the plasma protein beta-2 glycoprotein-1 (β2GPI) reduces LPS-induced inflammation in male mice. In the present study using a more robust infection model of septicaemia the role of β2GPI is examined in both male and female wild type (WT) and β2GPI deficient (β2GPI(-/-)) mice challenged with Escherichia coli (E...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811061/surgical-demographics-of-carpal-tunnel-syndrome-and-cubital-tunnel-syndrome-over-5-years-at-a-single-institution
#19
Dafang Zhang, Jamie E Collins, Brandon E Earp, Philip Blazar
PURPOSE: Carpal tunnel and cubital tunnel syndrome are the 2 most common upper-limb compressive neuropathies. However, whether the characteristics of patient populations undergoing surgery for these conditions are similar is unclear in terms of demographics and concomitant pathologies. Our null hypothesis was that there are no identifiable differences between these patient populations. METHODS: A retrospective cohort study was performed by billing system query using Common Procedural Terminology (CPT) codes for all patients who underwent open carpal tunnel release (CTR) (CPT code 64721) and/or open cubital tunnel surgery (CPT code 64718) by 1 of 4 hand surgeons from August 2008 to July 2013...
August 12, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28810963/treating-decompression-sickness-military-flight-simulation-site-community-hospital-partnership
#20
Whitney C Rhodes, George Hertner, Robert Price, Lani Finck, Claudia Temmer, Tracy Cushing, Kathleen Flarity
BACKGROUND: High-altitude flight simulation familiarizes military trainees with the symptoms of hypoxia to prepare them for emergency situations. Decompression sickness (DCS) can occur as a result of these simulations. In cases when ground-level supplemental oxygen does not resolve symptoms, hyperbaric oxygen (HBO) therapy is indicated. Many military hyperbaric chambers have been closed because of cost reductions, necessitating partnerships with community hospitals to ensure access to treatment...
July 2017: Military Medicine
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