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https://www.readbyqxmd.com/read/29683802/a-study-of-familial-char-syndrome-involving-the-tfap2b-gene-with-a-focus-on-facial-shape-characteristics
#1
Daniel Nyboe, Sven Kreiborg, Tron Darvann, Morten Dunø, Kamilla R Nissen, Hanne B Hove
In this case study, we investigate a child presenting with patent ductus arteriosus, short philtrum, duck-bill lips, strabismus, a flat nasal bridge, a broad forehead, low-set ears, hypertelorism, up-slanting palpebral fissures, almond-shaped eyes, and hypodontia, all leading to the clinical diagnosis of Char syndrome. Genetic analysis showed heterozygosity for the novel variant c.851T>C, p. Leu284Ser in the TFAP2B gene. Family analysis suggested that at least 20 members, extending six generations back, were affected...
April 20, 2018: Clinical Dysmorphology
https://www.readbyqxmd.com/read/29683465/dihydrogen-vs-hydrogen-bonding-in-the-solvation-of-ammonia-borane-by-tetrahydrofuran-and-liquid-ammonia
#2
David J Ingram, Thomas F Headen, Neal T Skipper, Samantha K Callear, Matthew Billing, Andrea Sella
The solvation structures of two systems rich in hydrogen and dihydrogen bonding interactions have been studied in detail experimentally through neutron diffraction with hydrogen/deuterium isotopic substitution. The results were analysed by an atomistic Monte Carlo simulation employing refinement to the experimental scattering data. The systems studied were the hydrogen storage material ammonia borane (NH3BH3, AB) dissolved in tetrahydrofuran (THF), and liquid ammonia (NH3), the latter in which AB shows unusually high solubility (260 g AB per 100 g NH3) and potential regeneration properties...
April 23, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29682309/australasian-society-for-hiv-viral-hepatitis-and-sexual-health-medicine-hiv-pre-exposure-prophylaxis-clinical-guidelines-update-april-2018
#3
EDITORIAL
Edwina Wright, Andrew Grulich, Katy Roy, Mark Boyd, Vincent Cornelisse, Darren Russell, Darryl O'Donnell, Bill Whittaker, Levinia Crooks, Iryna Zablotska
Daily use of coformulated tenofovir and emtricitabine for HIV pre-exposure prophylaxis (PrEP) by populations at high risk of HIV infection is now recommended in guidelines from the United States, Europe and Australia and globally through the 2015 WHO guidelines. These 2017 Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine's (ASHM) PrEP Guidelines are an updated adaptation of the 2014 US Centers for Disease Control's PrEP guidelines and are designed to: •Support the prescription of PrEP using forms of coformulated tenofovir and emtricitabine that have been registered in Australia by the Therapeutic Goods Administration and other bioequivalent generic drugs that are available in Australia through self-importation, private prescription or Australian PrEP clinical trials•Assist clinicians in the evaluation of patients who are seeking PrEP•Assist clinicians in commencing and monitoring patients on PrEP including PrEP dosing schedules, management of side-effects and toxicity, use of PrEP in pregnancy and in chronic hepatitis B infection and how to cease PrEP Daily PrEP with co-formulated tenofovir and emtricitabine, used continuously or for shorter periods of time, is recommended in these guidelines as a key HIV-prevention option for men who have sex with men (MSM), transgender men and women, heterosexual men and women, and people who inject drugs (PWID) at substantial risk of HIV acquisition...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29681440/community-pharmacist-directed-point-of-care-group-a-streptococcus-testing-evaluation-of-a-canadian-program
#4
John Papastergiou, Chantal Rene Trieu, Deborah Saltmarche, Artemis Diamantouros
OBJECTIVE: Streptococcus pyogenes is an aerobic, gram-positive bacterium responsible for a wide variety of infections including common pharyngitis. Novel rapid antigen detection tests allow for diagnosis of group A Streptococcus (GAS) at the point of care. The objective of the study is to evaluate the effects and feasibility of community pharmacist-directed GAS testing. SETTING: A retrospective analysis of aggregate billing data was conducted using descriptive statistics to evaluate the acceptance and feasibility of a community pharmacist-directed Streptococcus testing program at Shoppers Drug Mart pharmacies in the Canadian provinces of British Columbia, Alberta, and Nova Scotia...
April 19, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29679974/a-quantum-dynamical-study-of-the-rotation-of-the-dihydrogen-ligand-in-the-fe-h-2-h-2-petph-2-3-coordination-complex
#5
Megan E Gonzalez, Juergen Eckert, Adelia J A Aquino, Bill Poirier
Progress in the hydrogen fuel field requires a clear understanding and characterization of how materials of interest interact with hydrogen. Due to the inherently quantum mechanical nature of hydrogen nuclei, any theoretical studies of these systems must be treated quantum dynamically. One class of material that has been examined in this context are dihydrogen complexes. Since their discovery by Kubas in 1984, many such complexes have been studied both experimentally and theoretically. This particular study examines the rotational dynamics of the dihydrogen ligand in the Fe(H)2 (H2 )(PEtPh2 )3 complex, allowing for full motion in both the rotational degrees of freedom and treating the quantum dynamics (QD) explicitly...
April 21, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29678946/prenatal-antibiotic-exposure-and-childhood-asthma-a-population-based-study
#6
Keely Loewen, Barret Monchka, Salaheddin M Mahmud, Geert 't Jong, Meghan B Azad
Antibiotic use during infancy alters gut microbiota and immune development and is associated with an increased risk of childhood asthma. The impact of prenatal antibiotic exposure is unclear. We sought to characterise the association between prenatal antibiotic exposure and childhood asthma.We performed a population-based cohort study using prescription records, hospitalization records, and physician billing claims from 213,661 mother-child dyads born in Manitoba, Canada from 1996-2012. Associations were determined using Cox regression, adjusting for maternal asthma, postnatal antibiotics, and other potential confounders...
April 20, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29678771/prenatal-ethanol-induces-an-anxiety-phenotype-and-alters-expression-of-dynorphin-nociceptin-orphanin-fq-genes
#7
Aranza Wille-Bille, Roberto Sebastián Miranda-Morales, Mariangela Pucci, Fabio Bellia, Claudio D'Addario, Ricardo Marcos Pautassi
Animal models have suggested that prenatal ethanol exposure (PEE) alters the κ opioid receptor system. The present study investigated the brain expression of dynorphin and nociceptin/orphanin FQ related genes and assessed anxiety-like behavior in the light-dark box (LDB), shelter-seeking and risk-taking behaviors in the concentric square field (CSF) test, and ethanol-induced locomotion in the open field (OF), in infant or adolescent Wistar rats that were exposed to PEE (0.0 or 2.0 g/kg, intragastrically, gestational days 17-20)...
April 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29678459/impact-of-elementary-school-located-influenza-vaccinations-a-stepped-wedge-trial-across-a-community
#8
Peter G Szilagyi, Stanley Schaffer, Cynthia M Rand, Nicolas P N Goldstein, A Dirk Hightower, Mary Younge, Ashley Eagan, Aaron Blumkin, Christina S Albertin, Kristine DiBitetto, Cathleen Concannon, Phyllis Vincelli, Byung-Kwang Yoo, Sharon G Humiston
BACKGROUND: Influenza vaccination rates among children are low and novel strategies are needed to raise coverage. We measured the impact of school-located influenza vaccination (SLIV) on coverage, examined whether SLIV substitutes for practice-based influenza vaccination ("substitution"), and estimated whether a second year of experience with SLIV increases its impact. METHODS: We implemented a stepped wedge study design with schools as clusters. In Year 1, we randomly allocated schools to SLIV or control...
April 17, 2018: Vaccine
https://www.readbyqxmd.com/read/29678345/dimensions-around-the-nutrient-foramina-of-the-tibia-and-fibula-in-the-estimation-of-sex
#9
Mamorapelo D Fasemore, Mubarak A Bidmos, Palesa Mokoena, Aminu Imam, Brendon K Billings, Pedzisai Mazengenya
Sex estimation from skeletal remains is one of the key components in establishing a biological profile and consequent identification of an individual in a forensic and medico-legal practice. The use of dimensions around the nutrient foramen in instances where long bones may be fragmented and damaged is of benefit due to the fact that the nutrient foramen is easily identifiable and may be preserved on the shaft of long bones. This study is an investigation of the usefulness of various measurements around the nutrient foramen of the tibia and fibula of South Africans in an attempt to develop osteometric standards for sex estimation...
March 30, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29678342/spending-on-health-and-hiv-aids-domestic-health-spending-and-development-assistance-in-188-countries-1995-2015
#10
(no author information available yet)
BACKGROUND: Comparable estimates of health spending are crucial for the assessment of health systems and to optimally deploy health resources. The methods used to track health spending continue to evolve, but little is known about the distribution of spending across diseases. We developed improved estimates of health spending by source, including development assistance for health, and, for the first time, estimated HIV/AIDS spending on prevention and treatment and by source of funding, for 188 countries...
April 17, 2018: Lancet
https://www.readbyqxmd.com/read/29678341/trends-in-future-health-financing-and-coverage-future-health-spending-and-universal-health-coverage-in-188-countries-2016-40
#11
(no author information available yet)
BACKGROUND: Achieving universal health coverage (UHC) requires health financing systems that provide prepaid pooled resources for key health services without placing undue financial stress on households. Understanding current and future trajectories of health financing is vital for progress towards UHC. We used historical health financing data for 188 countries from 1995 to 2015 to estimate future scenarios of health spending and pooled health spending through to 2040. METHODS: We extracted historical data on gross domestic product (GDP) and health spending for 188 countries from 1995 to 2015, and projected annual GDP, development assistance for health, and government, out-of-pocket, and prepaid private health spending from 2015 through to 2040 as a reference scenario...
April 17, 2018: Lancet
https://www.readbyqxmd.com/read/29677939/estimating-a-bias-in-icd-encodings-for-billing-purposes
#12
Georg Fette, Markus Krug, Mathias Kaspar, Leon Liman, Georg Dietrich, Maximilian Ertl, Jonathan Krebs, Stefan Störk, Frank Puppe
ICD encoded diagnoses are a popular criterion for eligibility algorithms for study cohort recruitment. However, "official" ICD encoded diagnoses used for billing purposes are afflicted with a bias originating from legal issues. This work presents an approach to estimate the degree of the encoding bias for the complete ICD catalogue at a German university hospital. The free text diagnoses sections of discharge letters are automatically classified using a supervised machine learning algorithm. The automatic classifications are compared with the official, manually classified codes...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29676000/the-2016-hiv-diagnosis-and-care-cascade-in-new-south-wales-australia-meeting-the-unaids-90-90-90-targets
#13
Phillip Keen, Richard T Gray, Barbara Telfer, Rebecca Guy, Heather-Marie Schmidt, Bill Whittaker, Jo Holden, Martin Holt, Anthony Kelleher, David Wilson, Denton Callander, David A Cooper, Garrett Prestage, Christine Selvey, Andrew E Grulich
INTRODUCTION: The HIV Strategy in New South Wales (NSW) Australia aims to virtually eliminate HIV transmission by 2020. We estimated the 2016 HIV diagnosis and care cascade for the state of NSW, with a focus on introducing population-based data to improve data quality and assess progress towards the UNAIDS 90-90-90 targets. METHODS: To estimate the number of people living with diagnosed HIV (PLDHIV) we used NSW data from the Australian National HIV Registry, enhanced by surveillance among people recently diagnosed with HIV to improve migration estimates...
April 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29674936/the-man%C3%A3%C2%BA-gradient-as-a-study-system-for-bird-pollination
#14
Mannfred Ma Boehm, Micah N Scholer, Jeremiah Jc Kennedy, Julian M Heavyside, Aniceto Daza, David Guevara-Apaza, Jill E Jankowski
Background: This study establishes an altiudinal gradient, spanning from the highland Andes (2400 m) to lowland Amazon, as a productive region for the study of bird pollination in Southeastern Peru. The 'Manú Gradient' has a rich history of ornithological research, the published data and resources from which lay the groundwork for analyses of plant-bird interactions. In this preliminary expedition we documented 44 plants exhibting aspects of the bird pollination syndrome, and made field observations of hummingbird visits at three sites spanning the Manú Gradient: 2800 m (Wayqecha), 1400 m (San Pedro), and 400 m (Pantiacolla)...
2018: Biodiversity Data Journal
https://www.readbyqxmd.com/read/29672398/evaluating-quality-metrics-and-cost-after-discharge-a-population-based-cohort-study-of-value-in-health-care-following-elective-major-vascular-surgery
#15
Charles de Mestral, Konrad Salata, Mohamad A Hussain, Ahmed Kayssi, Mohammed Al-Omran, Graham Roche-Nagle
BACKGROUND: Early readmission to hospital after surgery is an omnipresent quality metric across surgical fields. We sought to understand the relative importance of hospital readmission among all health services received after hospital discharge. OBJECTIVE: The aim of this study was to characterize 30-day postdischarge cost and risk of an emergency department (ED) visit, readmission, or death after hospitalization for elective major vascular surgery. METHODS: This is a population-based retrospective cohort study of patients who underwent elective major vascular surgery - carotid endarterectomy, EVAR, open AAA repair, bypass for lower extremity peripheral arterial disease - in Ontario, Canada, between 2004 and 2015...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29669685/nurses-views-on-legalising-assisted-dying-in-new-zealand-a-cross-sectional-study
#16
Michael Wilson, Pam Oliver, Phillipa Malpas
AIMS: This study investigated New Zealand nurses' views on legalising assisted dying across a range of clinical conditions, nurses' willingness to engage in legal assisted dying, potential deterrents and enablers to such engagement, and nurses' perceptions of the proper role of their professional bodies in relation to legalising assisted dying. BACKGROUND: A Bill for legalising assisted dying is currently before the New Zealand parliament. Of the 16 jurisdictions where assisted dying has been specifically legislated, only the Canadian federal statute provides nurses with explicit legal protection for their performance of assisted dying-related tasks...
April 15, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29669063/society-of-behavioral-medicine-position-statement-increase-funding-for-fruits-and-vegetables-production-in-the-farm-bill-reauthorization
#17
Akilah Dulin-Keita, Lisa M Quintilliani, Joanna Buscemi, Brooke M Bell, Kim M Gans, Amy L Yaroch
The Society of Behavioral Medicine (SBM) recommends that Congress increase funding for fruit and vegetable production and intake in The Farm Bill reauthorization. Analysis of the U.S. Department of Agriculture's databases indicates that the availability of fruits and vegetables in the food supply is at half or less than half of what is needed to meet federal dietary recommendations for Americans. Based on the extant literature, SBM supports including funding allocations for fruit and vegetable production, including fruits and vegetables in commodity programs, providing additional insurance subsidies for producing fruits and vegetables, and maintaining or increasing funding for initiatives that promote fruit and vegetable intake...
April 13, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29667373/heritability-estimates-from-genome-wide-relatedness-matrices-in-wild-populations-application-to-a-passerine-using-a-small-sample-size
#18
C Perrier, B Delahaie, A Charmantier
Genomic developments have empowered the investigation of heritability in wild populations directly from genome wide relatedness matrices (GRM). Such GRM based approaches can in particular be used to improve or substitute approaches based on social pedigree (PED-social). However, measuring heritability from GRM in the wild has not been widely applied yet, especially using small samples and in non-model species. Here, we estimated heritability for four quantitative traits (tarsus length, wing length, bill length and body mass), using PED-social, a pedigree corrected by genetic data (PED-corrected) and a GRM from a small sample (n = 494) of blue tits from natural populations in Corsica genotyped at nearly 50,000 filtered SNPs derived from RAD-seq...
April 17, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29666904/pseudogout-among-patients-fulfilling-a-billing-code-algorithm-for-calcium-pyrophosphate-deposition-disease
#19
Sara K Tedeschi, Daniel H Solomon, Katherine P Liao
To test the performance of a billing claims-based calcium pyrophosphate deposition disease (CPPD) algorithm for identifying pseudogout. We applied a published CPPD algorithm at an academic institution and randomly selected 100 patients for electronic medical record review for 3 phenotypes: (1) definite/probable CPPD, (2) definite/probable pseudogout; (3) definite pseudogout. Clinical data were recorded and positive predictive value (PPV) (95% CI) for each phenotype was calculated. We then modified the published algorithm to require ≥ 1 of 4 relevant terms ("pseudogout", "calcium pyrophosphate crystals", "CPPD", or "chondrocalcinosis") through automated text searching in clinical notes, and re-calculated PPVs...
April 17, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29666586/ecological-and-phylogenetic-relationships-shape-the-peripheral-olfactory-systems-of-highly-specialized-gall-midges-cecidomiiydae
#20
Béla P Molnár, Tina Boddum, Sharon R Hill, Bill S Hansson, Ylva Hillbur, Göran Birgersson
Insects use sensitive olfactory systems to detect relevant host volatiles and avoid unsuitable hosts in a complex environmental odor landscape. Insects with short lifespans, such as gall midges (Diptera: Cecidomyiidae), are under strong selection pressure to detect and locate suitable hosts for their offspring in a short period of time. Ephemeral gall midges constitute excellent models for investigating the role of olfaction in host choice, host shift, and speciation. Midges mate near their site of emergence and females migrate in order to locate hosts for oviposition, thus females are expected to be more responsive to olfactory cues emitted by the host compared to males...
2018: Frontiers in Physiology
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