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https://www.readbyqxmd.com/read/29927715/personalized-herbal-medicine-a-roadmap-for-convergence-of-herbal-and-precision-medicine-biomarker-innovations
#1
Nicholas Ekow Thomford, Kevin Dzobo, Emile Chimusa, Kerstin Andrae-Marobela, Shadreck Chirikure, Ambroise Wonkam, Collet Dandara
While drugs remain the cornerstone of medicine, herbal medicine is an important comedication worldwide. Thus, precision medicine ought to face this clinical reality and develop "companion diagnostics" for drugs as well as herbal medicines. Yet, many are in denial with respect to the extent of use of traditional/herbal medicines, overlooking that a considerable number of contemporary therapeutic drugs trace their discovery from herbal medicines. This expert review underscores that absent such appropriate attention on both classical drug therapy and herbal medicines, precision medicine biomarkers will likely not stand the full test of clinical practice while patients continue to use both drugs and herbal medicines and, yet the biomarker research and applications focus only (or mostly) on drug therapy...
June 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29926465/il11ra-related-crouzon-like-autosomal-recessive-craniosynostosis-in-ten-new-patients-resemblances-and-differences
#2
E Brischoux-Boucher, Aurélien Trimouille, G Baujat, A Goldenberg, E Schaefer, B Guichard, P Hannequin, G Paternoster, S Baer, C Cabrol, E Weber, G Godfrin, M Lenoir, D Lacombe, C Collet, L Van Maldergem
By describing 10 new patients recruited in centres for Human Genetics, we further delineate the clinical spectrum of a Crouzon-like craniosynostosis disorder, officially termed craniosynostosis and dental anomalies (MIM614188). Singularly, it is inherited according to an autosomal recessive mode of inheritance. We identified 6 missense mutations in IL11RA, a gene encoding the alpha subunit of interleukin 11 receptor, 4 of them being novel, including 2 in the Ig-like C2-type domain. A subset of patients had an associated connective tissue disorder with joint hypermobility and intervertebral discs fragility...
June 21, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29909978/-batas-n%C3%A3-madas-in-madrid-salud-art-and-artists-in-professional-community-health-teams
#3
Mar Castillejo, Jorge Fernández-Cedena, Silvia Siles, María Dolores Claver, Noemí Ávila
OBJETIVE: This article describes the strategy of incorporating artists into the teams of community health in the city of Madrid, specifically in the Madrid Salud Centers. METHOD: The artistic colletive, Batas Nómadas, formed by three artists expertized in visual arts, has developed performances and participatory aproach to explain the incorporation of art and artists in these teams of professionals of Madrid Salud. RESULTS: Batas Nómadas has carried out sessions in 14 work teams of the Madrid Salud Centers and has collected data in a creative way from the 179 professionals that have participated in these sessions...
June 14, 2018: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29904818/pet-imaging-of-68-ga-nodaga-rgd-as-compared-with-18-f-fluorodeoxyglucose-in-experimental-rodent-models-of-engrafted-glioblastoma
#4
Sibel Isal, Julien Pierson, Laetitia Imbert, Alexandra Clement, Charlotte Collet, Sophie Pinel, Nicolas Veran, Aurélie Reinhard, Sylvain Poussier, Guillaume Gauchotte, Steeven Frezier, Gilles Karcher, Pierre-Yves Marie, Fatiha Maskali
BACKGROUND: Tracers triggering αvβ3 integrins, such as certain RGD-containing peptides, were found promising in previous pilot studies characterizing high-grade gliomas. However, only limited comparisons have been performed with current PET tracers. This study aimed at comparing the biodistribution of 18 F-fluorodeoxyglucose (18 F-FDG) with that of 68 Ga-NODAGA-RGD, an easily synthesized monomeric RGD compound with rapid kinetics, in two different rodent models of engrafted human glioblastoma...
June 15, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29898848/oral-anti-xa-anticoagulation-after-trans-aortic-valve-implantation-for-aortic-stenosis-the-randomized-atlantis-trial
#5
Jean-Philippe Collet, Sergio Berti, Angel Cequier, Eric Van Belle, Thierry Lefevre, Pascal Leprince, Franz-Josef Neumann, Eric Vicaut, Gilles Montalescot
BACKGROUND: Antithrombotic treatment regimen following transcatheter aortic valve replacement (TAVR) is not evidence-based. Apixaban, a non-vitamin K direct anticoagulant (NOAC) was shown to be superior to VKA and superior to aspirin to prevent cardioembolic stroke in non-valvular atrial fibrillation. It may have the potential to reduce TAVR-related thrombotic complications including subclinical valve thrombosis along with a better safety than the standard of care. DESIGN: ATLANTIS is a multicenter, randomized, phase IIIb, prospective, open-label, superiority study comparing standard of care (SOC Group) versus an apixaban-based strategy (Anti-Xa Group) after successful TAVR (ClinicalTrials...
June 2018: American Heart Journal
https://www.readbyqxmd.com/read/29898760/a-cost-effective-rflp-method-to-genotype-solute-carrier-organic-anion-1b1-slco1b1-c-1929a-c-p-leu643phe-rs34671512-a-variant-with-potential-effect-on-rosuvastatin-pharmacokinetics
#6
Nyarai D Soko, Collen Masimirembwa, Collet Dandara
OBJECTIVE: This study describes a restriction fragment polymorphism protocol for rapidly screening the polymorphism SLCO1B1 c.1929A>C in genomic DNA samples. The polymorphism SLCO1B1 c.1929A>C has been associated with increased activity resulting in increased hepatic uptake of drugs. Currently SLCO1B1 c.1929A>C is genotyped using direct sequencing techniques and 5' nuclease based assays which can be cost prohibiting in resource limited settings. The aim of this study therefore was to design and validate a cost effective RFLP for genotyping the SLCO1B1 c...
June 14, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29882592/is-a-specific-eyelid-patch-test-series-useful-results-of-a-french-prospective-study
#7
Haudrey Assier, Florence Tetart, Martine Avenel-Audran, Annick Barbaud, Marie-Christine Ferrier-le Bouëdec, Françoise Giordano-Labadie, Brigitte Milpied, Emmanuelle Amsler, Evelyne Collet, Pascal Girardin, Angèle Soria, Julie Waton, François Truchetet, Jean-Luc Bourrain, Gwendeline Gener, Claire Bernier, Nadia Raison-Peyron
BACKGROUND: Eyelids are frequent sites of contact dermatitis. No prospective study focused on eyelid allergic contact dermatitis (EACD) has yet been published, and this topic has never been studied in French patients. OBJECTIVES: To prospectively evaluate the usefulness of an eyelid series in French patients patch tested because of EACD, and to describe these patients. METHODS: We prospectively analysed standardized data for all patients referred to our departments between September 2014 and August 2016 for patch testing for suspected EACD as the main reason...
June 8, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29879420/doubling-immunochemistry-laboratory-testing-efficiency-with-the-cobas-e-801-module-while-maintaining-consistency-in-analytical-performance
#8
P Findeisen, I Zahn, G M Fiedler, A B Leichtle, S Wang, G Soria, P Johnson, J Henzell, J K Hegel, C Bendavid, N Collet, M McGovern, K Klopprogge
OBJECTIVES: The new immunochemistry cobas e 801 module (Roche Diagnostics) was developed to meet increasing demands on routine laboratories to further improve testing efficiency, while maintaining high quality and reliable data. DESIGN AND METHODS: During a non-interventional multicenter evaluation study, the overall performance, functionality and reliability of the new module was investigated under routine-like conditions. It was tested as a dedicated immunochemistry system at four sites and as a consolidator combined with clinical chemistry at three sites...
June 4, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29852010/distinct-domains-of-escherichia-coli-igaa-connect-envelope-stress-sensing-and-down-regulation-of-the-rcs-phosphorelay-across-subcellular-compartments
#9
Nahla A Hussein, Seung-Hyun Cho, Géraldine Laloux, Rania Siam, Jean-François Collet
In enterobacteria, the Rcs system (Regulator of capsule synthesis) monitors envelope integrity and induces a stress response when damages occur in the outer membrane or in the peptidoglycan layer. Built around a two-component system, Rcs controls gene expression via a cascade of phosphoryl transfer reactions. Being particularly complex, Rcs also involves the outer membrane lipoprotein RcsF and the inner membrane essential protein IgaA (Intracellular growth attenuator). RcsF and IgaA, which are located upstream of the phosphorelay, are required for normal Rcs functioning...
May 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29846630/impact-of-thyroid-hormone-therapy-on-atherosclerosis-in-the-elderly-with-subclinical-hypothyroidism-a-randomized-trial
#10
Manuel R Blum, Baris Gencer, Luise Adam, Martin Feller, Tinh-Hai Collet, Bruno R da Costa, Elisavet Moutzouri, Jörn Dopheide, Michèle Depairon, Gerasimos P Sykiotis, Patricia Kearney, Jacobijn Gussekloo, Rudi Westendorp, David J Stott, Douglas C Bauer, Nicolas Rodondi
Context: Subclinical hypothyroidism (SHypo) has been associated with atherosclerosis, but no conclusive clinical trials assessing the levothyroxine impact on carotid atherosclerosis exist. Objective: To assess the impact of treatment of SHypo with levothyroxine on carotid atherosclerosis. Design/Setting: Randomized, double-blind, placebo-controlled trial nested within the TRUST trial. Participants: Participants aged ≥65 years with SHypo (thyroid-stimulating hormone, TSH, 4...
May 28, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29844914/a-collet-sicard-syndrome-due-to-internal-carotid-artery-dissection-associated-with-cerebral-amyloid-angiopathy-related-inflammation
#11
Vanessa Saliou, Douraied Ben Salem, Julien Ognard, Dewi Guellec, Pascale Marcorelles, François Rouhart, Fabien Zagnoli, Serge Timsit
Background: Cerebral amyloid angiopathy-related inflammation is a rare condition with approximately 100 reported cases. Its clinical manifestations are varied. We report here a novel presentation of this disease. Case presentation: A 61-year-old Caucasian man presented with rapidly progressive paralysis of the IX, X, XI and XII right cranial nerves associated with right central facial nerve palsy. Brain computed tomography angiography and cerebral catheter angiography found a focal fusiform enlargement of the distal cervical portion of the right internal carotid artery, related to a pseudo-aneurysm suggesting an evolution of a dissection and intra-cranial vessel dysplasia...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29844473/expansion-of-human-primary-hepatocytes-in-vitro-through-their-amplification-as-liver-progenitors-in-a-3d-organoid-system
#12
Delphine Garnier, Ruoya Li, Frédéric Delbos, Angélique Fourrier, Camille Collet, Christiane Guguen-Guillouzo, Christophe Chesné, Tuan Huy Nguyen
Despite decades of investigation on the proliferation of adult human primary hepatocytes, their expansion in vitro still remains challenging. To later be able to consider hepatocytes as a cell therapy alternative or bridge to liver transplantation, dramatically impeded by a shortage in liver donors, the first step is having an almost unlimited source of these cells. The banking of transplantable hepatocytes also implies a protocol for their expansion that can be compatible with large-scale production. We show that adult human primary hepatocytes when grown in 3D organoids are easily amplified, providing a substantial source of functional hepatocytes ready for transplantation...
May 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29808084/optimal-combination-of-anodal-transcranial-direct-current-stimulations-and-motor-imagery-interventions
#13
Elodie Saruco, Franck Di Rienzo, Susana Nunez-Nagy, Miguel A Rubio-Gonzalez, Ursula Debarnot, Christian Collet, Aymeric Guillot, Arnaud Saimpont
Motor imagery contributes to enhance the (re)learning of motor skills through remapping of cortical networks. Combining motor imagery with anodal transcranial direct-current stimulation (a-tDCS) over the primary motor cortex has further been shown to promote its beneficial effects on postural control. Whether motor imagery should be performed concomitantly to a-tDCS (over depolarized membrane) or consecutively (over changing neurotransmitters activity) remains to be elucidated. In the present study, we measured the performance in a postural control task before and after three experimental conditions...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29802016/fractional-flow-reserve-derived-from-computed-tomographic-angiography-in-patients-with-multivessel-cad
#14
Carlos Collet, Yosuke Miyazaki, Nicola Ryan, Taku Asano, Erhan Tenekecioglu, Jeroen Sonck, Daniele Andreini, Manel Sabate, Salvatore Brugaletta, Rodney H Stables, Antonio Bartorelli, Robbert J de Winter, Yuki Katagiri, Ply Chichareon, Giovanni Luigi De Maria, Pannipa Suwannasom, Rafael Cavalcante, Hans Jonker, Marie-Angèle Morel, Bernard Cosyns, Arie P Kappetein, David T Taggart, Vasim Farooq, Javier Escaned, Adrian Banning, Yoshinobu Onuma, Patrick W Serruys
BACKGROUND: The functional SYNTAX score (FSS) has been shown to improve the discrimination for major adverse cardiac events compared with the anatomic SYNTAX score (SS) while reducing interobserver variability. However, evidence supporting the noninvasive FSS in patients with multivessel coronary artery disease (CAD) is scarce. OBJECTIVES: The purpose of this study was to assess the feasibility of and validate the noninvasive FSS derived from coronary computed tomography angiography (CTA) with fractional flow reserve (FFRCT ) in patients with 3-vessel CAD...
April 17, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29795186/protein-polarization-driven-by-nucleoid-exclusion-of-dnak-hsp70-substrate-complexes
#15
Clémence Collet, Jenny-Lee Thomassin, Olivera Francetic, Pierre Genevaux, Guy Tran Van Nhieu
Many bacterial proteins require specific subcellular localization for function. How Escherichia coli proteins localize at one pole, however, is still not understood. Here, we show that the DnaK (HSP70) chaperone controls unipolar localization of the Shigella IpaC type III secretion substrate. While preventing the formation of lethal IpaC aggregates, DnaK promoted the incorporation of IpaC into large and dynamic complexes (LDCs) restricted at the bacterial pole through nucleoid occlusion. Unlike stable polymers and aggregates, LDCs show dynamic behavior indicating that nucleoid occlusion also applies to complexes formed through transient interactions...
May 23, 2018: Nature Communications
https://www.readbyqxmd.com/read/29793088/decellularized-and-matured-esophageal-scaffold-for-circumferential-esophagus-replacement-proof-of-concept-in-a-pig-model
#16
Guillaume Luc, Guillaume Charles, Caroline Gronnier, Magali Cabau, Charlotte Kalisky, Mallory Meulle, Reine Bareille, Samantha Roques, Lionel Couraud, Johanna Rannou, Laurence Bordenave, Denis Collet, Marlène Durand
Surgical resection of the esophagus requires sacrificing a long portion of it. Its replacement by the demanding gastric pull-up or colonic interposition techniques may be avoided by using short biologic scaffolds composed of decellularized matrix (DM). The aim of this study was to prepare, characterize, and assess the in vivo remodeling of DM and its clinical impact in a preclinical model. A dynamic chemical and enzymatic decellularization protocol of porcine esophagus was set up and optimized. The resulting DM was mechanically and biologically characterized by DNA quantification, histology, and histomorphometry techniques...
May 17, 2018: Biomaterials
https://www.readbyqxmd.com/read/29777394/biomechanical-impact-of-wrong-positioning-of-a-dedicated-stent-for-coronary-bifurcations-a-virtual-bench-testing-study
#17
Claudio Chiastra, Maik J Grundeken, Carlos Collet, Wei Wu, Joanna J Wykrzykowska, Giancarlo Pennati, Gabriele Dubini, Francesco Migliavacca
The treatment of coronary bifurcations is challenging for interventional cardiologists. The Tryton stent (Tryton Medical, Inc., USA) is one of the few devices specifically designed for coronary bifurcations that underwent large clinical trials. Although the manufacturer provides specific recommendations to position the stent in the bifurcation side branch (SB) according to four radio-opaque markers under angiographic guidance, wrong device positioning may accidentally occur. In this study, the virtual bench testing approach was used to investigate the impact of wrong positioning of the Tryton stent in coronary bifurcations in terms of geometrical and biomechanical criteria...
May 17, 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29769836/a-revision-of-the-cleptoparasitic-bee-genus-epeolus-latreille-for-nearctic-species-north-of-mexico-hymenoptera-apidae
#18
Thomas M Onuferko
Herein, the cleptoparasitic (cuckoo) bee genus Epeolus (Hymenoptera: Apidae) is revised for species occurring in North America, north of Mexico, and an updated checklist of all species known to occur in Canada and the United States of America is provided with comprehensive descriptions, diagnoses, and a single dichotomous key (using the same couplets for both sexes) to aid in their identification. To increase their recognition among North American naturalists, English common names are also proposed for all North American Epeolus ...
2018: ZooKeys
https://www.readbyqxmd.com/read/29767323/prevalence-and-risk-factors-related-to-haloperidol-use-for-delirium-in-adult-intensive-care-patients-the-multinational-aid-icu-inception-cohort-study
#19
Marie O Collet, Jesús Caballero, Romain Sonneville, Fernando A Bozza, Peter Nydahl, Anna Schandl, Hilden Wøien, Giuseppe Citerio, Mark van den Boogaard, Johanna Hästbacka, Matthias Haenggi, Kirsten Colpaert, Louise Rose, Marija Barbateskovic, Theis Lange, Aksel Jensen, Martin B Krog, Ingrid Egerod, Helle L Nibro, Jørn Wetterslev, Anders Perner
PURPOSE: We assessed the prevalence and variables associated with haloperidol use for delirium in ICU patients and explored any associations of haloperidol use with 90-day mortality. METHODS: All acutely admitted, adult ICU patients were screened during a 2-week inception period. We followed the patient throughout their ICU stay and assessed 90-day mortality. We assessed patients and their variables in the first 24 and 72 h in ICU and studied their association together with that of ICU characteristics with haloperidol use...
May 16, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29762087/genomics-and-epigenomics-of-congenital-heart-defects-expert-review-and-lessons-learned-in-africa
#20
Nicholas Ekow Thomford, Kevin Dzobo, Nana Akyaa Yao, Emile Chimusa, Jonathan Evans, Emmanuel Okai, Paul Kruszka, Maximilian Muenke, Gordon Awandare, Ambroise Wonkam, Collet Dandara
Congenital heart defects (CHD) are structural malformations found at birth with a prevalence of 1%. The clinical trajectory of CHD is highly variable and thus in need of robust diagnostics and therapeutics. Major surgical interventions are often required for most CHDs. In Africa, despite advances in life sciences infrastructure and improving education of medical scholars, the limited clinical data suggest that CHD detection and correction are still not at par with the rest of the world. But the toll and genetics of CHDs in Africa has seldom been systematically investigated...
May 2018: Omics: a Journal of Integrative Biology
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