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M Barbateskovic, S R Kraus, M O Collet, O Mathiesen, J C Jakobsen, A Perner, J Wetterslev
BACKGROUND: In the intensive care unit, the prevalence of delirium is high. Delirium has been associated with morbidity and mortality including more ventilator days, longer intensive care unit stay, increased long-term mortality, and cognitive impairment. Thus, the burden of delirium for patients, relatives, and societies is considerable. The objective of this systematic review was to critically access the evidence of randomised clinical trials on the effects of haloperidol vs. placebo or any other agents for delirium in critically ill patients...
February 14, 2018: Acta Anaesthesiologica Scandinavica
Julie M Collet, Katrina McGuigan, Scott L Allen, Stephen F Chenoweth, Mark W Blows
Variational modules, sets of pleiotropically covarying traits, affect phenotypic evolution, and therefore are predicted to reflect functional modules, such that traits within a variational module also share a common function. Such an alignment of function and pleiotropy is expected to facilitate adaptation by reducing the deleterious effects of mutations, and allowing coordinated evolution of functionally related sets of traits. Here, we adopt a high-dimensional quantitative genetic approach using a large number of gene expression traits in Drosophila serrata to test whether functional grouping, defined by GO terms, predicts variational modules...
February 1, 2018: Genetics
Rodrigo Modolo, Yosuke Miyazaki, Ply Chichareon, Taku Asano, Carlos Collet, Erhan Tenekecioglu, Yuki Katagiri, Osama I I Soliman, Scot Garg, Yoshinobu Onuma, Patrick W Serruys
No abstract text is available yet for this article.
February 13, 2018: EuroIntervention
Victor Aboyans, Jean-Baptiste Ricco, Marie-Louise E L Bartelink, Martin Bjorck, Marianne Brodmann, Tina Cohnert, Jean-Philippe Collet, Martin Czerny, Marco De Carlo, Sebastian Debusa, Christine Espinola-Klein, Thomas Kahan, Serge Kownator, Lucia Mazzolai, A Ross Naylora, Marco Roffi, Joachim Rotherb, Muriel Sprynger, Michal Tendera, Gunnar Tepe, Maarit Venermoa, Charalambos Vlachopoulos, Ileana Desormais
No abstract text is available yet for this article.
February 2018: Revista Española de Cardiología
Zhenbo Cao, Lorna Mitchell, Oliver Hsia, Miriam Scarpa, Stuart T Caldwell, Arina D Alfred, Alexandra Gennaris, Jean-Francois Collet, Richard C Hartley, Neil J Bulleid
The oxidation of methionine residues in proteins occurs during oxidative stress and can lead to an alteration in protein function.  The enzyme methionine sulfoxide reductase reverses this modification.  Here we characterise the mammalian enzyme methionine sulfoxide reductase B3.  There are two splice variants of this enzyme that differ only in their N-terminal signal sequence, which directs the protein to either the ER or mitochondria.  We demonstrate here that the enzyme can complement a bacterial strain which is dependent upon methionine sulfoxide reduction for growth, that the purified recombinant protein is enzymatically active showing stereospecificity towards R -methionine sulfoxide, and identify the active site and two resolving cysteine residues...
February 2, 2018: Biochemical Journal
Charlotte Cohen, Williams Tessier, Caroline Gronnier, Florence Renaud, Arnaud Pasquer, Jérémie Théreaux, Johan Gagnière, Bernard Meunier, Denis Collet, Guillaume Piessen, Christophe Mariette
BACKGROUND: Locoregional recurrence rates after definitive chemoradiotherapy (dCRT) for locally advanced esophageal cancer (EC) are high. Salvage surgery (SALV) is considered the best treatment option in case of persistent or recurrent disease for operable patients, but SALV has been associated with increased morbidity and mortality. The aim of this study is to identify factors linked to outcomes after SALV to better select candidates and to optimize perioperative care. STUDY DESIGN: We retrospectively analyzed data from 308 consecutive SALV patients from a large multicenter European cohort...
February 7, 2018: Annals of Surgical Oncology
Nathanielly Cristina Carvalho de Brito Santos, Elenice Maria Cecchetti Vaz, Jordana Almeida Nogueira, Beatriz Rosana Gonçalves de Oliveira Toso, Neusa Collet, Altamira Pereira da Silva Reichert
The aim of this study is to compare traditional primary care units and family health units to determine which of the two models is better oriented towards primary care for children, considering the existence and scope of essential and intermediate attributes of primary care. We interviewed a total of 1,484 parents and guardians of children under 10 years of age enrolled in family health units in João Pessoa, Paraíba State, Brazil, as well as in traditional primary care units in Cascavel, Paraná State, Brazil, and mixed primary care units in Londrina, Paraná State, Brazil...
February 5, 2018: Cadernos de Saúde Pública
L Malcolm Hall, Catherine Collins, Bertrand Collet
The utility of molecular response data arising from in-vivo single and repeated measure fish disease-challenge experiments is compared. An in-silico 'experiment' involving the generation of two imaginary immune-molecule quantity response profiles over time for individual animals was carried out. Daily 'observed' molecule quantities were drawn from the 'known' individual response profiles to mimic the results of single and repeated measurement. The results indicate that repeated measure experiments are required to infer individual level response profiles, and that these experiments also provide more accurate summary statistics and data more suited to inferring the dependent ordering of the molecular response...
February 1, 2018: Fish & Shellfish Immunology
Vikas Thondapu, Erhan Tenekecioglu, Eric K W Poon, Carlos Collet, Ryo Torii, Christos V Bourantas, Cheng Chin, Yohei Sotomi, Hans Jonker, Jouke Dijkstra, Eve Revalor, Frank Gijsen, Yoshinobu Onuma, Andrew Ooi, Peter Barlis, Patrick W Serruys
Aims: As a sine qua non for arterial wall physiology, local hemodynamic forces such as endothelial shear stress (ESS) may influence long-term vessel changes as bioabsorbable scaffolds dissolve. The aim of this study was to perform serial computational fluid dynamic (CFD) simulations to examine immediate and long-term haemodynamic and vascular changes following bioresorbable scaffold placement. Methods and results: Coronary arterial models with long-term serial assessment (baseline and 5 years) were reconstructed through fusion of intravascular optical coherence tomography and angiography...
February 2, 2018: European Heart Journal
Jean-Philippe Collet, Guillaume Cayla, Pierre-Vladimir Ennezat, Florence Leclercq, Thomas Cuisset, Simon Elhadad, Patrick Henry, Loic Belle, Ariel Cohen, Johanne Silvain, Olivier Barthelemy, Farzin Beygui, Abdourahmane Diallo, Eric Vicaut, Gilles Montalescot
BACKGROUND: The prevalence and associated-risk of asymptomatic multisite artery disease (MSAD) in high risk coronary patients are unknown. Whether systematic identification and aggressive management of asymptomatic MSAD is clinically relevant in high risk coronary patients has not been evaluated. METHODS: We randomly assigned 521 high risk coronary patients defined by the presence of three-vessel coronary disease (n=304) or recent acute coronary syndrome beyond the age of 75years (n=215) to either a strategy of systematic detection of asymptomatic MSAD combined with an aggressive secondary prevention (n=263) or to a more conventional strategy based on treatment of coronary artery disease only with standard of care (n=258)...
March 1, 2018: International Journal of Cardiology
Anne Godier, Pierre Fontana, Serge Motte, Annick Steib, Fanny Bonhomme, Sylvie Schlumberger, Thomas Lecompte, Nadia Rosencher, Sophie Susen, André Vincentelli, Yves Gruel, Pierre Albaladejo, Jean-Philippe Collet
No abstract text is available yet for this article.
February 2, 2018: Archives of Cardiovascular Diseases
Pavel Overtchouk, Julien Pascal, Guillaume Lebreton, Jean-Sebastien Hulot, Charles-Edouard Luyt, Alain Combes, Mathieu Kerneis, Johanne Silvain, Olvier Barthelemy, Pascal Leprince, Nicolas Brechot, Gilles Montalescot, Jean-Philippe Collet
AIMS: To identify independent correlates of survival in patients undergoing PCI for refractory cardiogenic shock due to myocardial infarction (RCS-MI) with need for extracorporeal life support (ECLS). METHOD AND RESULTS: This observational single-tertiary-centre study enrolled 106 consecutive patients (52.7±10.4 years) with ECLS placed before or after the PCI. Half of the patients had triple vessel disease and PCI was attempted whenever possible (74.5%). The 30-day mortality rate was 63...
February 6, 2018: EuroIntervention
Sha-Sha Zhao, Shu Fang, Cheng-Ying Zhu, Li-Li Wang, Chun-Ji Gao
OBJECTIVE: To investigate the effect of granulocyte-colony stimulating factor (G-CSF) in vitro stimulation on the distribution of lymphocyte subset in healthy human. METHODS: Peripheral blood mononuclear cells (PBMNCs) were collected from 8 healthy volunteers by density gradient centrifugation on Ficoll-PaqueTM. In vitro 200 ng/ml G-CSF or 200 ng/ml G-CSF plus 10 µg/ml ConA directly act on PBMNCs, then the colleted cells were cultivated for 3 days. Lymphocyte subsets were stained with the corresponding fluoresce labeled antibodies and detected by flow cytometry...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
Li Chen, Ning Hu, Chao Wang, Hong-Mian Zhao
OBJECTIVE: To explore the effect of hypoxia on the cell proliferation and expression of hypoxia-inducible factor-1α(HIF-1α) of human leukemia K562 cells. METHODS: The leukemia cells were divided into 2 groups: hypoxia-treated group and conventional oxygen group as control. The K562 cells in hypoxia-treated group were treated with 50, 200, 400 and 800 µmol/L of CoCl2, while the K562 cells in control group were cultured in conventional oxygen condition, then the K562 cells in 2 groups were colleted after treatment for 24, 48 and 72 hours...
February 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
Oren Musicant, Assaf Botzer, Ilan Laufer, Christian Collet
Objective To study the relationship between physiological indices and kinematic indices during braking events of different intensities. Background Based on mental workload theory, driving and other task demands may generate changes in physiological indices, such as the driver's heart rate and skin conductance. However, no attempts were made to associate changes in physiological indices with changes in vehicle kinematics that result from the driver attempts to meet task demands. Method Twenty-five drivers participated in a field experiment...
February 1, 2018: Human Factors
Claudia Mehedințu, Lăcrămioara Aurelia Brîndușe, Elvira Brătilă, Michele Monroc, Ebticem Lemercier, Olivier Suaud, Cecile Collet-Savoye, Horace Roman
STUDY OBJECTIVE: To evaluate whether combining Computed Tomography-based virtual Colonoscopy (CTC) with Magnetic Resonance Imaging (MRI) improves preoperative assessment of colorectal endometriosis. DESIGN: Retrospective study using prospectively recorded data (Canadian Task Force classification II-2). SETTING: University tertiary referral center. PATIENTS: Seventy-one women treated for colorectal endometriosis managed between June 2015 and May 2016...
January 25, 2018: Journal of Minimally Invasive Gynecology
Céline Lafaye, Inge Van Molle, Veronica Tamu Dufe, Khadija Wahni, Ariane Boudier, Pierre Leroy, Jean-François Collet, Joris Messens
No abstract text is available yet for this article.
November 17, 2017: Journal of Biological Chemistry
Camille V Goemans, François Beaufay, Khadija Wahni, Inge Van Molle, Joris Messens, Jean François Collet
Thioredoxins (Trxs) are antioxidant proteins that are conserved among all species. These proteins have been extensively studied and perform reducing reactions on a broad range of substrates. Here, we identified Caulobacter crescentus Trx1 (CCNA_03653; CcTrx1) as an oxidoreductase that is involved in the cell cycle progression of this model bacterium and is required to sustain life. Intriguingly, the abundance of CcTrx1 varies throughout the C. crescentus cell cycle: while the expression of CcTrx1 is induced in stalked cells, right before DNA replication initiation, CcTrx1 is actively degraded by the ClpXP protease in predivisional cells...
January 24, 2018: Journal of Biological Chemistry
Michel Zeitouni, Johanne Silvain, Paul Guedeney, Mathieu Kerneis, Yan Yan, Pavel Overtchouk, Olivier Barthelemy, Marie Hauguel-Moreau, Rémi Choussat, Gérard Helft, Claude Le Feuvre, Jean-Philippe Collet, Gilles Montalescot
Aims: To assess the incidence, risk factors and prognosis of periprocedural myocardial infarction (MI) and myocardial injury in patients undergoing elective percutaneous coronary intervention (PCI). Methods and results: We included all consecutive patients who underwent elective PCI with a negative troponin level at admission from 1 January 2014 to 31 December 2015. The primary endpoint was defined as the composite of periprocedural MI (Type 4a MI), stent thrombosis (Type 4b MI), and myocardial injury according to the Third universal definition of MI...
January 20, 2018: European Heart Journal
Kevin Dzobo, Dimakatso Alice Senthebane, Nicholas Ekow Thomford, Arielle Rowe, Collet Dandara, M Iqbal Parker
Disruptive innovations in medicine are game-changing in nature and bring about radical shifts in the way we understand human diseases, their treatment, and/or prevention. Yet, disruptive innovations in cancer drug design and development are still limited. Therapies that cure all cancer patients are in short supply or do not exist at all. Chief among the causes of this predicament is drug resistance, a mechanism that is much more dynamic than previously understood. Drug resistance has limited the initial success experienced with biomarker-guided targeted therapies as well...
January 2018: Omics: a Journal of Integrative Biology
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