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https://www.readbyqxmd.com/read/28816644/cyp2b6-haplotype-predicts-efavirenz-plasma-concentration-in-black-south-african-hiv-1-infected-children-a-longitudinal-pediatric-pharmacogenomic-study
#1
Riaan Reay, Collet Dandara, Michelle Viljoen, Malie Rheeders
South Africa has the highest burden of the human immunodeficiency virus (HIV) infection globally. Efavirenz (EFV), a frequently used drug against HIV infection, displays a relationship between drug concentration and pharmacodynamics effects clinically. However, haplotype-based genetic variation in drug metabolism in a pediatric sample has been little considered in a longitudinal long-term context. CYP2B6 plays a key role in variation of EFV plasma concentration through altered drug metabolism. We report here on a prospective clinical pharmacogenomics/pharmacokinetic study of Bantu-speaking children, importantly, over a period of 24 months post-initiation of EFV-based treatment in South Africa...
August 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28800358/global-change-in-the-trophic-functioning-of-marine-food-webs
#2
Aurore Maureaud, Didier Gascuel, Mathieu Colléter, Maria L D Palomares, Hubert Du Pontavice, Daniel Pauly, William W L Cheung
The development of fisheries in the oceans, and other human drivers such as climate warming, have led to changes in species abundance, assemblages, trophic interactions, and ultimately in the functioning of marine food webs. Here, using a trophodynamic approach and global databases of catches and life history traits of marine species, we tested the hypothesis that anthropogenic ecological impacts may have led to changes in the global parameters defining the transfers of biomass within the food web. First, we developed two indicators to assess such changes: the Time Cumulated Indicator (TCI) measuring the residence time of biomass within the food web, and the Efficiency Cumulated Indicator (ECI) quantifying the fraction of secondary production reaching the top of the trophic chain...
2017: PloS One
https://www.readbyqxmd.com/read/28777381/mixotrophy-drives-niche-expansion-of-verrucomicrobial-methanotrophs
#3
Carlo R Carere, Kiel Hards, Karen M Houghton, Jean F Power, Ben McDonald, Christophe Collet, Daniel J Gapes, Richard Sparling, Eric S Boyd, Gregory M Cook, Chris Greening, Matthew B Stott
Aerobic methanotrophic bacteria have evolved a specialist lifestyle dependent on consumption of methane and other short-chain carbon compounds. However, their apparent substrate specialism runs contrary to the high relative abundance of these microorganisms in dynamic environments, where the availability of methane and oxygen fluctuates. In this work, we provide in situ and ex situ evidence that verrucomicrobial methanotrophs are mixotrophs. Verrucomicrobia-dominated soil communities from an acidic geothermal field in Rotokawa, New Zealand rapidly oxidised methane and hydrogen simultaneously...
August 4, 2017: ISME Journal
https://www.readbyqxmd.com/read/28766253/imaging-assessment-of-bioresorbable-vascular-scaffolds
#4
REVIEW
Yohei Sotomi, Pannipa Suwannasom, Erhan Tenekecioglu, Carlos Collet, Shimpei Nakatani, Takayuki Okamura, Takashi Muramatsu, Yuki Ishibashi, Hiroki Tateishi, Yosuke Miyazaki, Taku Asano, Yuki Katagiri, Constantin von Zur Muehlen, Kengo Tanabe, Ken Kozuma, Yukio Ozaki, Patrick W Serruys, Yoshinobu Onuma
Vascular reparative therapy has become a reality with bioresorbable scaffolds (BRSs). To assess acute and long-term performance of the device, multimodality imaging would be essential. Radiopacity of metal hinders the imaging assessment, whereas radiolucent polymeric scaffolds allow for a precise imaging assessment with either invasive or non-invasive modality at baseline and at follow-up, which is one of the advantages of polymeric BRSs. Recent large trials evaluating clinical results of the first-generation BRS technology raised concerns about the safety and efficacy of these devices, namely, scaffold thrombosis...
August 1, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28762976/formation-of-local-spin-state-concentration-waves-during-the-relaxation-from-a-photoinduced-state-in-a-spin-crossover-polymer
#5
Céline Mariette, Elzbieta Trzop, Serhane Zerdane, Pierre Fertey, Daopeng Zhang, Francisco J Valverde-Muñoz, José Antonio Real, Eric Collet
The complex relaxation from the photoinduced high-spin phase (PIHS) to the low-spin phase of the bimetallic two-dimensional coordination spin-crossover polymer [Fe[(Hg(SCN)3)2](4,4'-bipy)2]n is reported. During the thermal relaxation, commensurate and incommensurate spin-state concentration waves (SSCWs) form. However, contrary to the steps forming at thermal equilibrium, associated with long-range SSCW order, the SSCWs forming during the relaxation from the PIHS phase correspond to short-range order, revealed by diffuse X-ray scattering...
August 1, 2017: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
https://www.readbyqxmd.com/read/28754000/the-role-of-tumor-microenvironment-in-chemoresistance-to-survive-keep-your-enemies-closer
#6
REVIEW
Dimakatso Alice Senthebane, Arielle Rowe, Nicholas Ekow Thomford, Hendrina Shipanga, Daniella Munro, Mohammad A M Al Mazeedi, Hashim A M Almazyadi, Karlien Kallmeyer, Collet Dandara, Michael S Pepper, M Iqbal Parker, Kevin Dzobo
Chemoresistance is a leading cause of morbidity and mortality in cancer and it continues to be a challenge in cancer treatment. Chemoresistance is influenced by genetic and epigenetic alterations which affect drug uptake, metabolism and export of drugs at the cellular levels. While most research has focused on tumor cell autonomous mechanisms of chemoresistance, the tumor microenvironment has emerged as a key player in the development of chemoresistance and in malignant progression, thereby influencing the development of novel therapies in clinical oncology...
July 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28742698/survival-benefit-of-neoadjuvant-treatment-in-clinical-t3n0m0-esophageal-cancer-results-from-a-retrospective-multicenter-european-study
#7
Styliani Mantziari, Caroline Gronnier, Florence Renaud, Alain Duhamel, Jérémie Théreaux, Cécile Brigand, Nicolas Carrère, Jérémie H Lefevre, Arnaud Pasquer, Nicolas Demartines, Denis Collet, Bernard Meunier, Christophe Mariette
BACKGROUND: Based on current guidelines, clinical T3N0M0 esophageal tumors may or may not receive neoadjuvant treatment, according to their perception as locally advanced (cT3) or early-stage tumors (stage II). The study aim was to assess the impact of neoadjuvant treatment upon survival for cT3N0M0 esophageal cancer patients, with subgroup analyses by histological type (squamous cell carcinoma vs adenocarcinoma) and type of neoadjuvant treatment (chemotherapy vs radiochemotherapy). METHODS: Data from patients operated on for esophageal cancer in 30 European centers were collected...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28734923/diagnostic-accuracy-of-coronary-ct-angiography-for%C3%A2-the-evaluation-of-bioresorbable-vascular-scaffolds
#8
Carlos Collet, Bernard Chevalier, Angel Cequier, Jean Fajadet, Marcello Dominici, Steffen Helqvist, A J Van Boven, Dariusz Dudek, Dougal McClean, Manuel Almeida, Jan J Piek, Erhan Tenekecioglu, Antonio Bartorelli, Stephan Windecker, Patrick W Serruys, Yoshinobu Onuma
OBJECTIVES: To assess the diagnostic accuracy of coronary computed tomography angiography (CTA) for bioresorbable vascular scaffold (BVS) evaluation. BACKGROUND: Coronary CTA has emerged as a noninvasive method to evaluate patients with suspected or established coronary artery disease. The diagnostic accuracy of coronary CTA to evaluate angiographic outcomes after BVS implantation has not been well established. METHODS: In the ABSORB II (A Bioresorbable Everolimus-Eluting Scaffold Versus a Metallic Everolimus-Eluting Stent II) study, patients were randomized either to receive treatment with the BVS or everolimus-eluting metallic stent...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28727799/atlantic-salmon-cardiac-primary-cultures-an-in-vitro-model-to-study-viral-host-pathogen-interactions-and-pathogenesis
#9
Patricia A Noguera, Bianka Grunow, Matthias Klinger, Katherine Lester, Bertrand Collet, Jorge Del-Pozo
Development of Salmon Cardiac Primary Cultures (SCPCs) from Atlantic salmon pre-hatch embryos and their application as in vitro model for cardiotropic viral infection research are described. Producing SCPCs requires plating of trypsin dissociated embryos with subsequent targeted harvest from 24h up to 3 weeks, of relevant tissues after visual identification. SCPCs are then transferred individually to chambered wells for culture in isolation, with incubation at 15-22°. SCPCs production efficiency was not influenced by embryo's origin (0...
2017: PloS One
https://www.readbyqxmd.com/read/28717859/estimated-costs-of-clinical-and-surgical-treatment-of-severe-obesity-in-the-brazilian-public-health-system
#10
Paula Rosales Zubiaurre, Luciana Ribeiro Bahia, Michelle Quarti Machado da Rosa, Roberto Pereira Assumpção, Alexandre Vontobel Padoin, Samanta Pereira Sussembach, Everton Nunes da Silva, Claudio Corá Mottin
BACKGROUND: Obesity is a major global epidemic and a burden to society and health systems. This study aimed to estimate and compare the anual costs of clinical and surgical treatment of severe obesity from the perspective of the Brazilian Public Health System. METHODS: An observational and cross-sectional study was performed in three reference centers. Data collection on health resources utilization and productivity loss was carried out through an online questionnaire...
July 17, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28705563/la-transition-enfant-adulte-pour-les-patients-souffrant-de-troubles-des-conduites-alimentaires
#11
Corinne Blanchet-Collet, Hervé Lefevre, Marie Rose Moro
THE CHILD-ADULT TRANSITION FOR PATIENTS SUFFERING FROM EATING DISORDERS.: Eating disorders are chronic and evolutive psychiatric conditions which develop on a continuum between childhood and adulthood. The transition between child, adolescent and then adult care is a period of great vulnerability which may induce drop-out and aggravation of symptoms. In the case of eating disorders in particular, personalised transition programmes have been implemented in order to provide this support.
July 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28694669/magnetic-resonance-imaging-may-predict-deep-remission-in-patients-with-perianal-fistulizing-crohn-s-disease
#12
Lucie Thomassin, Laura Armengol-Debeir, Cloé Charpentier, Valerie Bridoux, Edith Koning, Guillaume Savoye, Céline Savoye-Collet
AIM: To evaluate the imaging course of Crohn's disease (CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor (TNF)-α therapy and identify predictors of deep remission. METHODS: All patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging (MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28692268/photoinduced-structural-dynamics-of-molecular-systems-mapped-by-time-resolved-x-ray-methods
#13
Majed Chergui, Eric Collet
We review the tremendous advances in ultrafast X-ray science, over the past 15 years, making the best use of new ultrashort X-ray sources including table-top or large-scale facilities. Different complementary X-ray-based techniques, including spectroscopy, scattering, and diffraction, are presented. The broad and expanding spectrum of these techniques in the ultrafast time domain is delivering new insight into the dynamics of molecular systems, of solutions, of solids, and of biosystems. Probing the time evolution of the electronic and structural degrees of freedom of these systems on the time scales of femtosecond to picoseconds delivers new insight into our understanding of dynamical matter...
July 10, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/28691911/a-novel-synchronized-diastolic-injection-method-to-reduce-contrast-volume-during-aortography-for-aortic-regurgitation-assessment-in-vitro-experiment-of-a-transcatheter-heart-valve-model
#14
Yosuke Miyazaki, Mohammad Abdelghani, Ellen S de Boer, Jean-Paul Aben, Math van Sloun, Todd Suchecki, Marcel van 't Veer, Carlos Collet, Taku Asano, Yuki Katagiri, Erhan Tenekecioglu, Osama I I Soliman, Yoshinobu Onuma, Robbert de Winter, Pim Tonino, Frans N van de Vosse, Marcel C M Rutten, Patrick W Serruys
AIMS: In the minimalist transcatheter aortic valve implantation (TAVI) era, the usage of transesophageal echocardiography becomes restricted. Conversely, aortography gains clinical ground in quantifying prosthetic valve regurgitation (PVR) during the procedure. In a mock circulation system, we sought to compare the contrast volume required and the accuracy of aortographic videodensitometric PVR assessment using a synchronized diastolic and standard (non-synchronized) injection aortography...
July 11, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28684430/percutaneous-coronary-intervention-has-similar-5-year-survival-rates-to-coronary-artery-bypass-grafting-surgery-for-patients-with-unprotected-left-main-artery-disease
#15
Carlos Collet, Patrick W Serruys
No abstract text is available yet for this article.
August 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28683293/a-specific-gut-microbiota-dysbiosis-of-type-2-diabetic-mice-induces-glp-1-resistance-through-an-enteric-no-dependent-and-gut-brain-axis-mechanism
#16
Estelle Grasset, Anthony Puel, Julie Charpentier, Xavier Collet, Jeffrey E Christensen, François Tercé, Rémy Burcelin
No abstract text is available yet for this article.
July 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28682397/copper-i-catalyzed-oxidative-hydrolysis-of-ugi-3-component-and-ugi-azide-reaction-products-towards-2%C3%A2-%C3%AE-ketoamides-and-%C3%AE-ketotetrazoles
#17
Jurriën W Collet, Christopher Foley, Arthur Y Shaw, Romano V A Orru, Eelco Ruijter, Christopher Hulme
Herein, a two-step MCR-oxidation methodology accessing decorated 2° α-ketoamides and α-ketotetrazoles is described via a catalytic copper(i)-mediated C-N oxidation/acidic hydrolysis of Ugi-three-component and Ugi-azide reaction products. The ability to install diversity from aldehyde and isocyanide synthons allows rapid complexity generation. Of note, (1) 2° α-ketoamides are traditionally difficult to access and more so reminiscent of the endogenous peptide bonds. (2) The route to α-keto-tetrazoles is significantly shorter than that in previous reports...
July 26, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28674071/-major-tom-to-ground-control-how-lipoproteins-communicate-extra-cytoplasmic-stress-to-the-decision-center-of-the-cell
#18
Géraldine Laloux, Jean-François Collet
The envelope of bacteria is a complex multi-layered shield that ensures multiple essential functions, including protecting the cell from external assaults. Hence, bacterial cells have evolved intricate mechanisms, called envelope stress response systems (ESRS), to monitor all kinds of perturbations affecting the integrity of their envelope and mount an appropriate response to contain or repair the damage. In the model bacterium Escherichia coli, several ESRS are built around a two-component system, in which envelope stress triggers a phosphotransfer between a sensor protein in the inner membrane of the envelope and a response regulator in the cytoplasm...
July 3, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28662806/temporal-trends-in-transcatheter-aortic%C3%A2-valve-replacement-in-france-france-2-to-france-tavi
#19
MULTICENTER STUDY
Vincent Auffret, Thierry Lefevre, Eric Van Belle, Hélène Eltchaninoff, Bernard Iung, René Koning, Pascal Motreff, Pascal Leprince, Jean Philippe Verhoye, Thibaut Manigold, Geraud Souteyrand, Dominique Boulmier, Patrick Joly, Frédéric Pinaud, Dominique Himbert, Jean Philippe Collet, Gilles Rioufol, Said Ghostine, Olivier Bar, Alain Dibie, Didier Champagnac, Lionel Leroux, Frédéric Collet, Emmanuel Teiger, Olivier Darremont, Thierry Folliguet, Florence Leclercq, Thibault Lhermusier, Patrick Olhmann, Bruno Huret, Luc Lorgis, Laurent Drogoul, Bernard Bertrand, Christian Spaulding, Laurent Quilliet, Thomas Cuisset, Maxence Delomez, Farzin Beygui, Jean-Philippe Claudel, Alain Hepp, Arnaud Jegou, Antoine Gommeaux, Anfani Mirode, Luc Christiaens, Charles Christophe, Claude Cassat, Damien Metz, Lionel Mangin, Karl Isaaz, Laurent Jacquemin, Philippe Guyon, Christophe Pouillot, Serge Makowski, Vincent Bataille, Josep Rodés-Cabau, Martine Gilard, Hervé Le Breton
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is standard therapy for patients with severe aortic stenosis who are at high surgical risk. However, national data regarding procedural characteristics and clinical outcomes over time are limited. OBJECTIVES: The aim of this study was to assess nationwide performance trends and clinical outcomes of TAVR during a 6-year period. METHODS: TAVRs performed in 48 centers across France between January 2013 and December 2015 were prospectively included in the FRANCE TAVI (French Transcatheter Aortic Valve Implantation) registry...
July 4, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28649954/in-vitro-validation-of-coronary-ct-angiography-for-the-evaluation-of-complex-lesions
#20
Carlos Collet, Yoshinobu Onuma, Maik J Grundeken, Yosuke Miyazaki, Marcio Bittercourt, Pieter Kitslaar, Sadako Motoyama, Yukio Ozaki, Taku Asano, Jolanda J Wentzel, Geert J Streekstra, Patrick W Serruys, Robbert J de Winter, Nihls Planken
AIMS: To assess in vitro the diagnostic accuracy of computed tomography angiography (CTA) for the evaluation of complex coronary lesions. METHODS AND RESULTS: Five Plexiglas phantoms with three bifurcations lesions each were designed to mimic the anatomic variations and fractal phenomenon of the coronary tree. In addition, luminal stenosis were scaled up with increases of 10%. A third generation dual-source computed tomography was used. Automated quantitative CTA analysis was performed...
June 27, 2017: EuroIntervention
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