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https://www.readbyqxmd.com/read/27644666/predictive-value-of-the-pattern-of-%C3%AE-catenin-expression-for-pathological-response-to-neoadjuvant-chemotherapy-in-breast-cancer-patients
#1
S Elsamany, O Elemam, S Elmorsy, A Alzahrani, M M Abbas
PURPOSE: This study aimed to explore the association of β-catenin expression pattern with pathological response after neoadjuvant chemotherapy in breast cancer (BC) patients. MATERIALS AND METHODS: In this retrospective exploratory study, data for 50 BC patients who received neoadjuvant chemotherapy were recorded. β-catenin expression in tumours was assessed using immunohistochemistry and classified as either membranous or cytoplasmic according to the pattern of staining...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27340922/early-versus-late-distant-metastasis-and-adjuvant-chemotherapy-alone-versus-both-radiotherapy-and-chemotherapy-in-molecular-apocrine-breast-cancer
#2
Xiaozhen Liu, Yang Yang, Xiaolong Feng, Honghong Shen, Jian Liu, Xia Liu, Yun Niu
As a new subtype of breast cancer, molecular apocrine breast cancer (MABC) is estrogen receptor (ER) and progesterone receptor (PR) negative expression, but androgen receptor (AR) positive expression. The prognostic significance and clinical biological behavior of MABC have remained unclear up to now. This study aimed to analysis the distant metastasis behavior and response to adjuvant radiotherapy and chemotherapy of MABC subgroup. The report showed that there were significant differences between early and late distant metastasizing tumors with respect to Ki67, epidermal growth factor receptor 2 (HER2) and vascular endothelial growth factor (VEGF) expressions by a retrospective analysis consisting of 410 invasive breast cancer patients, which included 205 MABC and 205 nonMABC cases...
June 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27336608/efficacy-of-focal-adhesion-kinase-inhibition-in-non-small-cell-lung-cancer-with-oncogenically-activated-mapk-pathways
#3
Hao Zhang, Huanjie Shao, Vita M Golubovskaya, Hongbin Chen, William Cance, Alex A Adjei, Grace K Dy
BACKGROUND: Focal adhesion kinase (FAK) is overexpressed in many types of tumours, including lung cancer. Y15, a small molecule which inhibits Y397 FAK autophosphorylation, decreases growth of human neuroblastoma, breast and pancreatic cancers. In this study, we investigated the in vitro and in vivo effects of Y15, and the underlying mechanism on non-small cell lung cancer cells. METHODS: The cytotoxic effects of Y15 targeting FAK signalling were evaluated. Gene-knockdown experiments were performed to determine the anti-cancer mechanism...
July 12, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/26537078/predictors-determining-the-status-of-axilla-in-breast-cancer-where-is-pet-ct-on-that
#4
Huseyin Ozgur Aytac, Tamer Colacoglu, Gul Nihal Nursal, Tarik Zafer Nursal, Filiz Aka Bolat, Hakan Yabanoglu, Sedat Yildirim, Gokhan Moray
PURPOSE: 18 F-FDG PET/CT has an acceptable specificity but a low sensitivity on the prediction of axillary lymph node (ALN) metastasis in breast cancer. We analyzed the factors that could possibly affect this prediction. METHODS: The records of 270 patients with T1-2 invasive breast cancer who underwent surgery, 116 of whom had been evaluated by preoperative 18 F-FDG PET/CT were reviewed. Prediction of ALN status by PET/CT according to tumor stage, estrogen receptor (ER), progesterone receptor (PgR) and HER2 status, histology, age and sentinel node properties was assessed...
September 2015: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/26202679/epithelial-mesenchymal-transition-and-drug-resistance-in-breast-cancer-review
#5
REVIEW
Jing Huang, Hongzhong Li, Guosheng Ren
Breast cancer is the leading cause of cancer death in women worldwide. Insensitivity of tumor cells to drug therapies is an essential reason arousing such high mortality. Epithelial-mesenchymal transition (EMT) is defined by the loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. It is well known that EMT plays an important role in breast cancer progression. Recently, mounting evidence has demonstrated involvement of EMT in antagonizing chemotherapy in breast cancer. Here, we discuss the biological significance and clinical implications of these findings, with an emphasis on novel approaches that effectively target EMT to increase the efficacy of anticancer therapies...
September 2015: International Journal of Oncology
https://www.readbyqxmd.com/read/25841412/from-genomic-data-analysis-to-drug-development-a-new-generation-of-trials-using-molecular-marker-assessment-in-breast-cance
#6
Sophie Doisneau-Sixou, Nadia Harbeck
With the advent of molecular subtypes in breast cancer, the landscape of clinical trials and drug development is rapidly changing. Molecular screening identifies numerous mutations but actually druggable targets are few and far between. Thus, new clinical trial concepts are needed which are feasible in clinical practice and successful from the point of view of drug development. This article highlights the evolution of the sequencing technologies, the current molecular screening efforts and their impact on drug development as well as novel successful trial designs, focusing on the hormone receptor (HR) positive breast cancer patients...
June 2014: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/25326692/high-focal-adhesion-kinase-expression-in-breast-carcinoma-is-associated-with-lymphovascular-invasion-and-triple-negative-phenotype
#7
Vita M Golubovskaya, Lourdes Ylagan, Austin Miller, Melissa Hughes, Jason Wilson, David Wang, Elizabeth Brese, Wiam Bshara, Stephen Edge, Carl Morrison, William G Cance
BACKGROUND: Focal adhesion Kinase (FAK) is a nonreceptor protein tyrosine kinase that is overexpressed in tumors and plays a significant role in tumor survival and metastasis. The purpose of the study is to perform correlation of FAK expression with patient prognostic factors using tissue microarrays (TMA) samples. METHODS: We analyzed FAK expression by immunohistochemical staining in 196 breast primary tumor samples from stage II-IV patients and in 117 metastatic tissues matched to the primary tumors using TMA that were stained with FAK monoclonal antibody...
2014: BMC Cancer
https://www.readbyqxmd.com/read/25300626/oprm1-receptor-as-new-biomarker-to-help-the-prediction-of-post-mastectomy-pain-and-recurrence-in-breast-cancer
#8
M De Gregori, L Diatchenko, I Belfer, M Allegri
Breast cancer is the most common type of cancer among women worldwide. Short-term postsurgical recovery is complicated by many factors, including imbalanced inflammatory and immune response, acute pain associated with functional impairment, and chronic postmastectomy pain (CPMP), developed by about 25-60% of patients. Opioids, most common drugs used for treatment of cancer pain, are immunosuppressive, and therefore, they might directly and/or indirectly influence long-term cancer recurrence. Moreover, they also produce endocrinopathy, which consists primarily of hypothalamic-pituitary-gonadal axis or hypothalamic-pituitary-adrenal axis dysfunction...
August 2015: Minerva Anestesiologica
https://www.readbyqxmd.com/read/25024076/front-line-transplantation-program-with-lenalidomide-bortezomib-and-dexamethasone-combination-as-induction-and-consolidation-followed-by-lenalidomide-maintenance-in-patients-with-multiple-myeloma-a-phase-ii-study-by-the-intergroupe-francophone-du-my%C3%A3-lome
#9
MULTICENTER STUDY
Murielle Roussel, Valérie Lauwers-Cances, Nelly Robillard, Cyrille Hulin, Xavier Leleu, Lotfi Benboubker, Gérald Marit, Philippe Moreau, Brigitte Pegourie, Denis Caillot, Christophe Fruchart, Anne-Marie Stoppa, Catherine Gentil, Soraya Wuilleme, Anne Huynh, Benjamin Hebraud, Jill Corre, Marie-Lorraine Chretien, Thierry Facon, Hervé Avet-Loiseau, Michel Attal
PURPOSE: The three-drug combination of lenalidomide, bortezomib, and dexamethasone (RVD) has shown significant efficacy in multiple myeloma (MM). The Intergroupe Francophone du Myélome (IFM) decided to evaluate RVD induction and consolidation therapies in a sequential intensive strategy for previously untreated transplantation-eligible patients with MM. PATIENTS AND METHODS: In this phase II study, 31 symptomatic patients age < 65 years were enrolled to receive three RVD induction cycles followed by cyclophosphamide harvest and transplantation...
September 1, 2014: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/24289553/epidemiology-major-risk-factors-and-genetic-predisposition-for-breast-cancer-in-the-pakistani-population
#10
REVIEW
Uzma Shaukat, Muhammad Ismail, Nasir Mehmood
Occurrence of breast cancer is related to genetic as well as cultural, environmental and life-style factors. Variations in diversity of these factors among different ethnic groups and geographical areas emphasize the immense need for studies in all racial-ethnic populations. The incidence of breast cancer in Pakistan is highest in Asians after Jews in Israel and 2.5 times higher than that in neighboring countries like Iran and India, accounting for 34.6% of female cancers. The Pakistani population is deficient in information regarding breast cancer etiology and epidemiology, but efforts done so far had suggested consanguinity as a major risk factor for frequent mutations leading to breast cancer and has also shed light on genetic origins in different ethnic groups within Pakistan...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/23882956/geographic-epidemiology-in-a-small-area-cancer-incidence-in-baakline-lebanon-2000-2008
#11
S M Adib, N Tabbal, R Hamadeh, W Ammar
Aggregate data of the National Clr cac gi s in Lebanon cannot discriminate cance r incidence i n small areas. Trained community members surveyed the permanent population of the Baakline municipality using the verbal autopsy approach. We surveyed 1042 households with at least 1 member living permanently in Baakline during 2000-2008. Data covered 4330 persons yielding 34,143 years of observation and 56 new cases of cancer were reported. Median age at diagnosis varied significantly between men (77 years) and women (56 years)...
April 2013: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/22402131/a-small-molecule-focal-adhesion-kinase-fak-inhibitor-targeting-y397-site-1-2-hydroxyethyl-3-5-7-triaza-1-azoniatricyclo-3-3-1-1-3-7-decane-bromide-effectively-inhibits-fak-autophosphorylation-activity-and-decreases-cancer-cell-viability-clonogenicity-and-tumor
#12
Vita M Golubovskaya, Sheila Figel, Baotran T Ho, Christopher P Johnson, Michael Yemma, Grace Huang, Min Zheng, Carl Nyberg, Andrew Magis, David A Ostrov, Irwin H Gelman, William G Cance
Focal adhesion kinase (FAK) is a protein tyrosine kinase that is overexpressed in most solid types of tumors and plays an important role in the survival signaling. Recently, we have developed a novel computer modeling combined with a functional assay approach to target the main autophosphorylation site of FAK (Y397). Using these approaches, we identified 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide, called Y11, a small molecule inhibitor targeting Y397 site of FAK. Y11 significantly and specifically decreased FAK autophosphorylation, directly bound to the N-terminal domain of FAK...
May 2012: Carcinogenesis
https://www.readbyqxmd.com/read/22292772/mitoxantrone-targets-the-atp-binding-site-of-fak-binds-the-fak-kinase-domain-and-decreases-fak-pyk-2-c-src-and-igf-1r-in-vitro-kinase-activities
#13
Vita M Golubovskaya, Baotran Ho, Min Zheng, Andrew Magis, David Ostrov, William G Cance
Focal Adhesion Kinase (FAK) is a non-receptor kinase that is overexpressed in many types of tumors and plays a key role in cell adhesion, spreading, motility, proliferation, invasion, angiogenesis, and survival. Recently, FAK has been proposed as a target for cancer therapy, and we performed computer modeling and screening of the National Cancer Institute (NCI) small molecule compounds database to target the ATP-binding site of FAK, K454. More than 140,000 small molecule compounds were docked into the crystal structure of the kinase domain of FAK in 100 different orientations using DOCK5...
May 2013: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/22292771/a-small-molecule-inhibitor-5-o-tritylthymidine-targets-fak-and-mdm-2-interaction-and-blocks-breast-and-colon-tumorigenesis-in-vivo
#14
Vita M Golubovskaya, Nadia L Palma, Min Zheng, Baotran Ho, Andrew Magis, David Ostrov, William G Cance
Focal Adhesion Kinase (FAK) is overexpressed in many types of tumors and plays an important role in survival. We developed a novel approach, targeting FAK-protein interactions by computer modeling and screening of NCI small molecule drug database. In this report we targeted FAK and Mdm-2 protein interaction to decrease tumor growth. By macromolecular modeling we found a model of FAK and Mdm-2 interaction and performed screening of > 200,000 small molecule compounds from NCI database with drug-like characteristics, targeting the FAK-Mdm-2 interaction...
May 2013: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/21490922/ikk%C3%AE-regulates-the-repair-of-dna-double-strand-breaks-induced-by-ionizing-radiation-in-mcf-7-breast-cancer-cells
#15
Lixian Wu, Lijian Shao, Ningfei An, Junru Wang, Senthil Pazhanisamy, Wei Feng, Martin Hauer-Jensen, Shigeki Miyamoto, Daohong Zhou
Activation of the IKK-NFκB pathway increases the resistance of cancer cells to ionizing radiation (IR). This effect has been largely attributed to the induction of anti-apoptotic proteins by NFκB. Since efficient repair of DNA double strand breaks (DSBs) is required for the clonogenic survival of irradiated cells, we investigated if activation of the IKK-NFκB pathway also regulates DSB repair to promote cell survival after IR. We found that inhibition of the IKK-NFκB pathway with a specific IKKβ inhibitor significantly reduced the repair of IR-induced DSBs in MCF-7 cells...
2011: PloS One
https://www.readbyqxmd.com/read/21385053/melatonin-receptors-melatonin-metabolizing-enzymes-and-cyclin-d1-in-human-breast-cancer
#16
Olga Rögelsperger, Katrin Wlcek, Cem Ekmekcioglu, Susanne Humpeler, Martin Svoboda, Robert Königsberg, Martin Klimpfinger, Walter Jäger, Theresia Thalhammer
BACKGROUND: Melatonin suppresses breast cancer cell proliferation by inhibiting the upregulation of estrogen-induced cyclin D1 via its G-protein-coupled receptor MT1. Additionally, melatonin stimulates the expression of the estrogen sulfotransferase, SULT1E1. However, metabolism of melatonin via 6-hydroxylation by CYP1A1/1A2 and subsequent sulfonation by SULT1A1/1A3 decreases its intracellular concentration. This could have a negative impact on its oncostatic action in breast cancer. PATIENTS AND METHODS: In this pilot study, we performed immunohistochemical (IHC) analysis of MT1 and cyclin D1 in breast cancer specimens from 33 patients...
April 2011: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/20515733/focal-adhesion-kinase-and-p53-signal-transduction-pathways-in-cancer
#17
REVIEW
Vita M Golubovskaya, William Cance
Human cancer is characterized by a process of tumor cell motility, invasion, and metastasis. One of the critical tyrosine kinases that is linked to these processes of tumor invasion and survival is the Focal Adhesion Kinase (FAK). Our laboratory was the first to isolate FAK from human tumors, and we had demonstrated that FAK mRNA was up-regulated in invasive and metastatic human breast and colon cancer samples. We have cloned FAK promoter and have found that FAK promoter contains p53 binding sites, and that p53 inhibits FAK transcription and regulates its expression in tumor samples...
June 1, 2010: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/20145184/tipifarnib-plus-tamoxifen-in-tamoxifen-resistant-metastatic-breast-cancer-a-negative-phase-ii-and-screening-of-potential-therapeutic-markers-by-proteomic-analysis
#18
Florence Dalenc, Sophie F Doisneau-Sixou, Ben C Allal, Sabrina Marsili, Valérie Lauwers-Cances, Karima Chaoui, Odile Schiltz, Bernard Monsarrat, Thomas Filleron, Nicole Renée, Emilie Malissein, Elise Meunier, Gilles Favre, Henri Roché
PURPOSE: Tipifarnib, a farnesyltransferase inhibitor, has antitumor activity in heavily pretreated metastatic breast cancer patients. Preclinical data suggest that FTIs could restore tamoxifen responsiveness in tamoxifen-resistant disease. Thus, combining FTIs and tamoxifen may be a promising clinical approach after relapse or progression on tamoxifen. EXPERIMENTAL DESIGN: Postmenopausal patients with measurable estrogen receptor- and/or progesterone receptor-expressing metastatic breast cancers were enrolled...
February 15, 2010: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/19671193/the-direct-effect-of-focal-adhesion-kinase-fak-dominant-negative-fak-fak-cd-and-fak-sirna-on-gene-expression-and-human-mcf-7-breast-cancer-cell-tumorigenesis
#19
Vita M Golubovskaya, Min Zheng, Li Zhang, Jian-Liang Li, William G Cance
BACKGROUND: Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays an important role in survival signaling. FAK has been shown to be overexpressed in breast cancer tumors at early stages of tumorigenesis. METHODS: To study the direct effect of FAK on breast tumorigenesis, we developed Tet-ON (tetracycline-inducible) system of MCF-7 breast cancer cells stably transfected with FAK or dominant-negative, C-terminal domain of FAK (FAK-CD), and also FAKsiRNA with silenced FAK MCF-7 stable cell line...
August 12, 2009: BMC Cancer
https://www.readbyqxmd.com/read/19610651/small-molecule-chloropyramine-hydrochloride-c4-targets-the-binding-site-of-focal-adhesion-kinase-and-vascular-endothelial-growth-factor-receptor-3-and-suppresses-breast-cancer-growth-in-vivo
#20
Elena V Kurenova, Darell L Hunt, Dihua He, Andrew T Magis, David A Ostrov, William G Cance
FAK is a tyrosine kinase that functions as a key orchestrator of signals leading to invasion and metastasis. Since FAK interacts directly with a number of critical proteins involved in survival signaling in tumor cells, we hypothesized that targeting a key protein-protein interface with druglike small molecules was a feasible strategy for inhibiting tumor growth. In this study, we targeted the protein-protein interface between FAK and VEGFR-3 and identified compound C4 (chloropyramine hydrochloride) as a drug capable of (1) inhibiting the biochemical function of VEGFR-3 and FAK, (2) inhibiting proliferation of a diverse set of cancer cell types in vitro, and (3) reducing tumor growth in vivo...
August 13, 2009: Journal of Medicinal Chemistry
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