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Jovana de Moura Milanesi, Luana Cristina Berwig, Mariana Marquezan, Luiz Henrique Schuch, Anaelena Bragança de Moraes, Ana Maria Toniolo da Silva, Eliane Castilhos Rodrigues Corrêa
PURPOSE: : This study was conducted to identify variables associated with mouth breathing diagnosis in children, based on multidisciplinary domains. METHODS: 119 children, six to 12 years old, underwent anamnesis, speech therapy (orofacial structures and stomatognathic functions), otorhinolaryngologic (OTRL) with clinical and endoscopic examinations, dental (occlusion) and physiotherapy (body posture and nasal patency) assessments. Nasal patency was evaluated using Peak Nasal Inspiratory Flow (PNIF) and the Nasal Obstruction Symptom Evaluation (NOSE) scale...
March 19, 2018: CoDAS
Jeffrey Braithwaite, Peter D Hibbert, Adam Jaffe, Les White, Christopher T Cowell, Mark F Harris, William B Runciman, Andrew R Hallahan, Gavin Wheaton, Helena M Williams, Elisabeth Murphy, Charlotte J Molloy, Louise K Wiles, Shanthi Ramanathan, Gaston Arnolda, Hsuen P Ting, Tamara D Hooper, Natalie Szabo, John G Wakefield, Clifford F Hughes, Annette Schmiede, Chris Dalton, Sarah Dalton, Joanna Holt, Liam Donaldson, Ed Kelley, Richard Lilford, Peter Lachman, Stephen Muething
Importance: The quality of routine care for children is rarely assessed, and then usually in single settings or for single clinical conditions. Objective: To estimate the quality of health care for children in Australia in inpatient and ambulatory health care settings. Design, Setting, and Participants: Multistage stratified sample with medical record review to assess adherence with quality indicators extracted from clinical practice guidelines for 17 common, high-burden clinical conditions (noncommunicable [n = 5], mental health [n = 4], acute infection [n = 7], and injury [n = 1]), such as asthma, attention-deficit/hyperactivity disorder, tonsillitis, and head injury...
March 20, 2018: JAMA: the Journal of the American Medical Association
Qingxia Yao, Karl P Fischer, D Lorne Tyrrell, Klaus S Gutfreund
Programmed death-1 (PD-1), upon engagement by its ligands, programmed death ligand-1 (PD-L1) and programmed death ligand-2 (PD-L2), provides signals that attenuate adaptive immune responses. Here we describe the identification of the Pekin duck PD-L2 (duPD-L2) and its gene structure. The duPD-L2 cDNA encodes a 321 amino acid protein that has an amino acid identity of 76% and 35% with chicken and human PD-L2, respectively. Mapping of the duPD-L2 cDNA with duck genomic sequences revealed an exonic structure similar to that of the human P dcd1lg2 gene...
March 2018: Biochemistry and Biophysics Reports
Herbert B Allen, Saagar Jadeja, Rina M Allawh, Kavita Goyal
Group A Streptococcus has been identified as a possible etiologic agent in psoriasis in epidemiologic, immunologic, immunopathologic, medical, and surgical studies. Tonsillectomy has been shown to provide considerable relief to 75% of patients with plaque psoriasis. Even with the substantial evidence supporting group A Streptococcus as a causative pathogen in psoriasis, it is an elusive pathogen because it is not culturable, nor does it exhibit any positive serologic evidence of its presence. One possible reason for the negative cultures and negative serology findings with group A Streptococcus is the development of biofilms...
March 2018: Ear, Nose, & Throat Journal
Lu Gan, Mengyuan Zhu, Xiaozhao Li, Chen Chen, Ting Meng, Jiaxi Pu, Huiming Luo, Fengmin Shao, Qiaoling Zhou
BACKGROUND: Tonsillitis can promote the progression of IgA nephropathy (IgAN) by aggravating immunopathologic response. Th22 cell disorder is involved in the pathogenesis of IgAN with tonsillitis. This study was determined to explore the possible mechanism of IgAN with tonsillitis underlying Th22 cell chemotaxis response to the effect of CCL20, CCL22, and CCL27. METHODS: This research was conducted on 65 subjects including 16 healthy controls (HC group), 5 patients with  renal carcinoma (HTC group) and 44 patients with IgAN between 2015 and 2016...
March 16, 2018: International Urology and Nephrology
M Salakova, E Koslabova, M Grega, J Smahelova, J Klozar, O Vencalek, R Tachezy
Human papillomavirus (HPV) infection is associated with tonsillar cancer (TC) whose incidence in humans is increasing. Tonsillar tumours are not ordinarily preceded by clinically apparent precancerous lesions, and no markers of the early stage disease are available. Therefore, we evaluated the presence of an active HPV infection also in tumour-free tonsillar tissue. Formalin-fixed paraffin-embedded (FFPE) tonsillar specimens from 114 patients with TC and 114 age and gender matched controls were screened for the presence of HPV DNA, expression of HR-HPV E6 mRNA, and p16 overexpression...
2018: Neoplasma
W H Hou, P Wei, J L Xie, Y Y Zheng, Y L Zhang, X G Zhou
Objective: To investigate clinicopathological features and prognosis of tonsillar mantle cell lymphoma(TMCL). Methods: Clinical data of 25 patients with TMCL at Beijing Friendship Hospital, Capital Medical University from 2002 to 2016 were included. All the cases were reviewed microscopically. Various immunohistochemical stains were performed using the MaxVision two-step method. IgH/CCND1 gene fusion was detected by fluorescent in situ hybridization(FISH). Additionally, randomly selected 40 cases of non-tonsil MCL of the same period were compared...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Muhammed Sedat Sakat, Korhan Kilic, Ayhan Kars, Mustafa Kara, Mustafa Sitki Gozeler
Objective: Tonsillectomy is one of the most common surgical procedures performed at ear, nose, and throat clinics. Chronic recurrent tonsillitis, obstructive tonsillitis, and halitosis are among the most common indications for surgery. Determining whether the infection is chronic and the patient's annual number of infections are important in estimating the necessity for surgery to be performed due to infectious causes. Red blood cell distribution width (RDW) is a numerical value present in normal complete blood count that provides information about erythrocytes and their dimensions...
February 2018: Eurasian Journal of Medicine
Man-Yee Man, Hoi-Ping Shum, Wing-Wa Yan, Susanna K P Lau
We report a 21-year-old young male with Lemierre's syndrome presented as tonsillitis and Fusobacterium septicemia with respiratory failure and required intensive care. Lemierre's syndrome is the septic embolic complication of recent pharyngeal illness. Fusobacterium spp. accounts for the majority of cases. High index of suspicion is needed and prolonged antibiotic is advised. It is seldom seen in intensive care but should never be forgotten.
February 2018: Indian Journal of Critical Care Medicine
Andrew Smith, Sandra Winter, David Lappin, Andrea Sherriff, Ian McIvor, Pamela Philp, Nigel Suttner, Sulisti Holmes, Alan Stewart
BACKGROUND: Currently UK vCJD cases total 178, with an estimated maximum 1:2,000 carriage rate based on archived appendix and tonsil tissue, implying infection maybe rare but carriage relatively common. Previous workers have identified that maintenance of surgical instruments in a humid atmosphere after use and prior to cleaning assists cleaning efficacy. Relatively recently the Department of Health/Advisory Committee on Dangerous Pathogens UK have recommended a surgical instrument cleanliness threshold post cleaning of <5μg protein per instrument side...
March 9, 2018: Journal of Hospital Infection
Yunfei Gao, Jiaoping Mi, Fenghong Chen, Zhenpeng Liao, Xiaoshan Feng, Minghui Lv, Haixin He, Yujie Cao, Yan Yan, Zhe Zhu, Yunping Fan, Haiyu Hong
PURPOSE: Chronic tonsillitis (TC) is among the most common bacterial diseases in pediatric otolaryngology. We aimed to evaluate the expression of glycogen synthase kinase 3β (GSK-3β) in a cohort of children with chronic tonsillitis (TC), and the correlation between GSK-3β activity index and inflammatory profiles of TC. MATERIALS AND METHODS: The expression of GSK-3β was comparably evaluated between children with TC (n = 26) and tonsillar hypertrophy (TH, n = 26)...
March 3, 2018: American Journal of Otolaryngology
Melanie Christine Föll, Matthias Fahrner, Victor Oginga Oria, Markus Kühs, Martin Lothar Biniossek, Martin Werner, Peter Bronsert, Oliver Schilling
Background: Proteomic analyses of clinical specimens often rely on human tissues preserved through formalin-fixation and paraffin embedding (FFPE). Minimal sample consumption is the key to preserve the integrity of pathological archives but also to deal with minimal invasive core biopsies. This has been achieved by using the acid-labile surfactant RapiGest in combination with a direct trypsinization (DTR) strategy. A critical comparison of the DTR protocol with the most commonly used filter aided sample preparation (FASP) protocol is lacking...
2018: Clinical Proteomics
Hsueh-Yu Li, Li-Ang Lee, Eric J Kezirian, Meiho Nakayama
Suspension palatoplasty, a new surgical technique to treat obstructive sleep apnea (OSA), has been developed to correct the retropalatal obstruction in patients with small tonsils (grade I/II) and anterior-posterior palatal (A-P) obstruction. The objecteive of this preliminary study was to investigate the effectiveness and change in retropalatal airway dimensions after suspension palatoplasty. This retrospective case series study included 25 consecutive male adults with OSA. Unique technical features of suspension palatoplasty are exposure of pterygomandibular raphe and suspension of palatopharyngeus muscle to the raphe...
March 9, 2018: Scientific Reports
Amy Talbot, Carys Lippiatt, Avanish Tantry
A 2-year-old boy with a history of pica was admitted with vomiting and treated overnight for viral tonsillitis. A week later, he presented with a prolonged afebrile seizure and required intubation and ventilation. Antibiotics and acyclovir were started. Despite extensive investigations including MRI head, no cause was identified. Four days later, he deteriorated with signs of raised intracranial pressure. On day 5, blood lead concentration in the sample collected at admission was reported as grossly elevated, consistent with a diagnosis of severe lead poisoning from ingesting lead-containing paint at the family home...
March 9, 2018: BMJ Case Reports
Jeremy P Harris, Michelle M Chen, Ryan K Orosco, Davud Sirjani, Vasu Divi, Wendy Hara
Importance: Shortening the time from surgery to the start of radiation (TS-RT) is a consideration for physicians and patients. Although the National Comprehensive Cancer Network recommends radiation to start within 6 weeks, a survival benefit with this metric remains controversial. Objective: To determine the association of delayed TS-RT with overall survival (OS) using a large cancer registry. Design, Setting, and Participants: In this observational cohort study, 25 216 patients with nonmetastatic stages III to IV head and neck cancer were identified from the National Cancer Database (NCDB)...
March 8, 2018: JAMA Otolaryngology—Head & Neck Surgery
Adonye Banigo, Ahmad Moinie, Nigel Bleach, Meera Chand, Vicki Chalker, Theresa Lamagni
OBJECTIVES: To determine if there is a correlation between falling tonsillectomy numbers and increasing numbers of tonsillitis admissions and invasive Group A β-haemolytic streptococcus (iGAS) infection in children aged 14 and under in England. DESIGN: An observational cross-sectional study was performed. SETTING: The data extracted covered the period from 1991 until 2014. PARTICIPANTS: Hospital admissions for tonsillectomies, tonsillitis/pharyngitis, and and all diagnoses of iGAS in children aged 14 and under who had a tonsillectomy...
March 5, 2018: Clinical Otolaryngology
Lei Jin, Keyong Li, Xiaoyan Li
OBJECTIVE: To investigate the diagnostic value of distortion product otoacoustic emission (DPOAE) together with tympanometry in assessing otitis media with effusion in children. METHODS: Three hundred and thirty-nine patients, who were diagnosed with obstructive sleep apnea-hypopnea syndrome (OSAHS) and prepared to undergo adenotonsillectomy and had a unilateral or bilateral type 'B' or 'C' tympanogram were enrolled in this study. Patients were divided into the following four groups: Group 1, type 'B' tympanogram with positive DPOAE; Group 2, type 'B' tympanogram with negative DPOAE; Group 3, type 'C' tympanogram with positive DPOAE and Group 4, type 'C' tympanogram with negative DPOAE...
March 5, 2018: Acta Oto-laryngologica
Yukiko Komeno, Yasunori Ota, Tomohiko Koibuchi, Yoichi Imai, Kuniko Iihara, Tomiko Ryu
BACKGROUND Syphilis is a sexually transmitted disease caused by the pathogen Treponema pallidum. Prevalence continues to rise, especially among men who have sex with men (MSM). Due to changes in patterns of sexual activity, manifestations of the disease are highly variable. CASE REPORT A 27-year-old male visited the hospital for a low-grade fever and tender 5-cm mass in the right side of his neck. His right tonsil was swollen and covered with a white coating. Levofloxacin was prescribed, but ineffective. The patient's levels of liver function enzymes increased gradually...
March 4, 2018: American Journal of Case Reports
Carolina Sánchez-Rodríguez, Keyliz R Peraza Cruces, Laura Rodrigáñez Riesco, José Antonio García-Vela, Ricardo Sanz-Fernández
BACKGROUND: Recurrent tonsillitis might reduce the immunological capability of fighting against the infection of tonsil tissue. Polypodium leucotomos (Anapsos) immunomodulating effect has been subject of research in the last years. The aim of this research is to test the in vitro immunomodulating capacity of Anapsos in a child palatine tonsil explants model. METHODS: Palatine tonsils explants of children undergoing amigdalectomy were stimulated with mononuclear cells obtained from their own blood by density gradient centrifugation...
April 2018: International Journal of Pediatric Otorhinolaryngology
Steven W Coutras, Alexander Limjuco, Kristin E Davis, Michele M Carr
OBJECTIVES: Describe the patterns of obstruction in persistent pediatric OSA and their relationship with patient weight. STUDY DESIGN: Retrospective review. METHODS: All pediatric DISE procedures performed at a tertiary care hospital between October 2010 and October 2015 were reviewed. Patients had polysomnography after adenotonsillectomy that confirmed persistent obstructive sleep apnea (OSA). Variables included age, gender, co-morbidities, and AHI...
April 2018: International Journal of Pediatric Otorhinolaryngology
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