Mohammed N Tantawy, J Oliver McIntyre, Fiona Yull, M Wade Calcutt, Dmitry S Koktysh, Andrew J Wilson, Zhongliang Zu, Jeff Nyman, Julie Rhoades, Todd E Peterson, Daniel Colvin, Lisa J McCawley, Jerri M Rook, Barbara Fingleton, Marta Ann Crispens, Ronald D Alvarez, John C Gore
BACKGROUND: It has been shown that tumor microenvironment (TME) hydroxyapatite (HAP) is typically associated with many malignancies and plays a role in tumor progression and growth. Additionally, acidosis in the TME has been reported to play a key role in selecting for a more aggressive tumor phenotype, drug resistance and desensitization to immunotherapy for many types of cancers. TME-HAP is an attractive target for tumor detection and treatment development since HAP is generally absent from normal soft tissue...
January 18, 2024: Cancer Medicine