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Occult breast cancer

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https://www.readbyqxmd.com/read/28064227/pet-probe-guided-surgery-in-patients-with-breast-cancer-proposal-for-a-methodological-approach
#1
Paolo Orsaria, Agostino Chiaravalloti, Alessandro Fiorentini, Chiara Pistolese, Gianluca Vanni, Alessandra Vittoria Granai, Dimitrios Varvaras, Roberta Danieli, Orazio Schillaci, Giuseppe Petrella, Oreste Claudio Buonomo
BACKGROUND: Although it is valuable for detecting distant metastases, identifying recurrence, and evaluating responses to chemotherapy, the role of (18)F-fluorodeoxyglucose positron-emission tomography/computed tomography ((18)F-FDG PET/CT) in assessing locoregional nodal status for initial staging of breast cancer has not yet been well-defined in clinical practice. In the current report, we describe a new PET probe-based clinical approach, with evaluation of the technical performance of a handheld high-energy gamma probe for intraoperative localization of breast carcinomas, and evaluation of lymph node metastases during radio-guided oncological surgery...
January 2017: In Vivo
https://www.readbyqxmd.com/read/28058560/intraoperative-margin-management-in-breast-conserving-surgery-a-systematic-review-of-the-literature
#2
Richard J Gray, Barbara A Pockaj, Erin Garvey, Sarah Blair
BACKGROUND: Breast surgeons have a wide variety of intraoperative techniques available to help achieve low rates for positive margins of excision, with variable levels of evidence. METHODS: A systematic review of the medical literature from 1995 to July 2016 was conducted, with 434 abstracts identified and evaluated. The analysis included 106 papers focused on intraoperative management of breast cancer margins and contained actionable data. RESULTS: Ultrasound-guided lumpectomy for palpable tumors, as an alternative to palpation guidance, can lower positive margin rates, but the effect when used as an alternative to wire localization (WL) for nonpalpable tumors is less certain...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28026205/preoperative-breast-mri-surgeons-patient-selection-patterns-and-potential-bias-in-outcomes-analyses
#3
Jiyon Lee, Elaine Tanaka, Peter R Eby, Shouhao Zhou, Wei Wei, Christine Eppelheimer, Vilert A Loving
OBJECTIVE: The purpose of this study is to determine which patient- and tumor-related and clinical variables influence dedicated breast surgeons' and general surgeons' referrals for preoperative breast MRI for patients with newly diagnosed breast cancer. MATERIALS AND METHODS: Surgeons who perform breast surgery responded to a survey from June 16, 2014, through August 11, 2014. Participants self-identified as breast or general surgeons and provided professional practice details...
December 27, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27941567/a-serous-peritoneal-cancer-revealing-itself-with-double-breast-cancer-metastases-in-2-different-periods
#4
Kemal Beksac, Cigdem Irkkan, Guldeniz Argun, Bahadir Cetin
A 72-year-old woman presented with a mass on the right axilla. This was thought to be an occult breast cancer case, and the patient was treated with modified radical mastectomy, followed by hormonotherapy. Two years later she presented with incarcerated umbilical hernia. Pathology revealed Sister Mary Joseph's nodule inside the hernia sac. Further evaluation revealed that the primary tumor was papillary serous carcinoma of the peritoneal surface. The patient received adjuvant chemotherapy. Two years later the metastatic tumor was located on the other breast...
December 9, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27908767/should-we-routinely-analyze-reduction-mammaplasty-specimens
#5
Päivi A Merkkola-von Schantz, Tiina A Jahkola, Leena A Krogerus, Katja S Hukkinen, Susanna Mc Kauhanen
BACKGROUND: Reduction mammaplasty is one of the most common plastic surgery procedures. Preoperative imaging and histopathology protocols vary among countries and institutions. We aimed to analyze the incidence of occult breast cancer and high-risk lesions in reduction mammaplasty specimens. We also analyzed whether patients with abnormal histopathology differed from the study population in terms of demographics. PATIENTS AND METHODS: In total, 918 women who underwent reduction mammaplasty from January 2007 to December 2011 were retrospectively reviewed for demographics, preoperative imaging, further preoperative examinations, pathology reports, and postoperative follow-up...
November 10, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27870337/breast-cancers-found-with-digital-breast-tomosynthesis-a-comparison-of-pathology-and-histologic-grade
#6
Wei-Shin Wang, Lara Hardesty, James Borgstede, Jayme Takahashi, Sharon Sams
To compare the pathology and histologic grading of breast cancers detected with digital breast tomosynthesis to those found with conventional digital mammography. The institutional review board approved this study. A database search for all breast cancers diagnosed from June 2012 through December 2013 was performed. Imaging records for these cancers were reviewed and patients who had screening mammography with tomosynthesis as their initial examination were selected. Five dedicated breast imaging radiologists reviewed each of these screening mammograms to determine whether the cancer was visible on conventional digital mammography or whether tomosynthesis was needed to identify the cancer...
November 2016: Breast Journal
https://www.readbyqxmd.com/read/27869446/-oncopathological-aspects-of-brca1-and-brca2-genes-inactivation-in-tumors-of-ovary-fallopian-tube-and-pelvic-peritoneum
#7
Petr Škapa, Pavel Dundr
Ovarian carcinoma represents a heterogeneous group of malignant epithelial tumors which could be divided into two fundamental groups: Type I (endometrioid carcinoma, clear cell carcinoma, low grade serous carcinoma, mucinous carcinoma and more rare seromucinous carcinoma and malignant Brenner tumor) and type II (high grade serous carcinoma - HGSC). HGSC is the most frequent ovarian carcinoma which may be etiologically linked to inactivation of tumor suppressor genes BRCA1/2 and TP53 and differs from type I carcinomas by higher aggressiveness, tendency to peritoneal spread and worse prognosis...
2016: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/27853496/a-case-of-a-concurrent-and-co-located-invasive-carcinoma-and-a-fibroadenoma-to-illustrate-the-potential-of-dual-energy-contrast-enhanced-digital-mammography-on-the-diagnosis-of-complex-breast-lesions
#8
Maria Del Mar Travieso Aja, Purificacion Munoz, Mario Rodriguez Rodriguez, Victor Vega Benitez, Octavio P Luzardo
Up to 19% of breast malignancies may be missed by conventional imaging techniques, especially when they are concurrent or co-located with other benign lesions. However, more sensitive techniques, such as magnetic resonance imaging (MRI), are often too expensive for routine use in developing countries. Contrast-enhanced, dual-energy digital mammography (CESM) is a recently introduced imaging modality whose performance has been reported to be similar to that of MRI. Being much cheaper, CESM may constitute a good alternative for improving diagnostic sensitivity in these countries...
July 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27847287/pet-ct-with-18-f-fdg-predicts-short-term-outcome-in-stage-ii-iii-breast-cancer-patients-upstaged-to-n2-3-nodal-disease
#9
S C Teixeira, B B Koolen, P H M Elkhuizen, M-J T F D Vrancken Peeters, M P M Stokkel, S Rodenhuis, V van der Noort, E J T Rutgers, R A Valdés Olmos
INTRODUCTION: (18)F-FDG PET/CT has high positive predictive value for the detection of avid lymph node metastases in breast cancer patients. We analysed the effect of upstaging lymph nodes by PET/CT on short-term outcome in stage II/III breast cancer patients. PATIENTS AND METHODS: A total of 278 stage II/III primary breast cancer patients (mean age 48.9 years, range 19-75 years) were re-staged with (18)F-FDG PET/CT before start of pre-operative systemic treatment (PST)...
October 31, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27842732/the-true-impact-of-breast-magnetic-resonance-imaging-on-the-management-of-in-situ-disease-more-is-not-better
#10
Michael Lallemand, Morgan Barron, Jason Bingham, Andrew Mosier, Mark Hardin, Vance Sohn
BACKGROUND: The optimal role of breast magnetic resonance imaging (MRI) in the management of ductal carcinoma in situ (DCIS) remains controversial. We sought to better define the impact of breast MRIs when utilized during the workup of DCIS. METHODS: Patients with biopsy-proven DCIS without any additional invasive disease were prospectively enrolled in the multidisciplinary breast cancer pathway and comprised the study group. Patients who met any additional criteria for MRI screening were excluded...
January 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/27822324/sonographically-unusual-breast-carcinomas-2-case-reports
#11
Gozde Arslan, Levent Celik
BACKGROUND: For infiltrative breast lesions; sonography might not always be as helpful as mammography and MRI (magnetic resonance imaging). For higher sensitivity and specificity, these 3 imaging methods should be carried out together. Radiologists should be aware of the patient's history and complaints. Patients who have a specific history like a long-term drug treatment or a palpable tumour should be approached differently. CASE REPORT: We would like to present 2 cases with atypical sonographic findings...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27813620/occult-breast-primary-malignancy-presenting-as-isolated-axillary-lymph-node-metastasis-early-detection-of-primary-site-by-18f-fdg-pet-ct
#12
Ramya Soundararajan, Niraj Naswa, Sellam Karunanithi, Ritika Walia, Rakesh Kumar, Chandrasekhar Bal
Breast cancer patients rarely present with isolated axillary lymph node metastasis without any clinical or radiological evidence of primary tumor. Identification of the primary site of tumor helps in planning appropriate patient management which has definite impact on patient's survival. We present here a case of 30-year-old female who presented with isolated right axillary lymph node metastasis with no evidence of primary tumor clinically. Conventional imaging modalities were negative for primary site. She underwent whole body 18F-Flurodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) and it contributed significantly in early detection of occult primary tumor in right breast...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27762607/molecular-breast-imaging-for-screening-in-dense-breasts-state-of-the-art-and-future-directions
#13
Carrie B Hruska
OBJECTIVE: The purposes of this review are to discuss the motivation for supplemental screening, to address molecular breast imaging (MBI) radiation dose concerns, and to provide an updated guide to current MBI technology, clinical protocols, and screening performance. Future directions of MBI are also discussed. CONCLUSION: MBI offers detection of mammographically occult cancers in women with dense breasts. Although MBI has been under investigation for nearly 15 years, it has yet to gain widespread adoption in breast screening...
October 20, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27738627/methodological-aspects-of-99m-tc-sestamibi-guided-biopsy-in-breast-cancer
#14
A Collarino, R A Valdés Olmos, A F van der Hoeven, L M Pereira Arias-Bouda
PURPOSE: This review aims to discuss the methodological aspects of dedicated molecular breast imaging (MBI) using (99m)Tc-sestamibi as radiotracer to guide biopsy of occult or unclear breast lesions on mammography (MG) and ultrasound (US) that are suspicious on MBI (BI-RADS criteria 4 and 5), including its advantages, limitations and future clinical applications. METHODS: Literature search was performed using the PubMed/MEDLINE database and "(99m)Tc-sestamibi", "biopsy" and "breast cancer" as keywords...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27715711/strategies-to-increase-cancer-detection-review-of-true-positive-and-false-negative-results-at-digital-breast-tomosynthesis-screening
#15
Katrina E Korhonen, Susan P Weinstein, Elizabeth S McDonald, Emily F Conant
Digital breast tomosynthesis (DBT) represents a valuable addition to breast cancer screening by decreasing recall rates while increasing cancer detection rates. The increased accuracy achieved with DBT is due to the quasi-three-dimensional format of the reconstructed images and the ability to "scroll through" breast tissue in the reconstructed images, thereby reducing the effect of tissue superimposition found with conventional planar digital mammography. The margins of both benign and malignant lesions are more conspicuous at DBT, which allows improved lesion characterization, increased reader confidence, and improved screening outcomes...
November 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27713603/the-early-predictive-value-of-right-ventricular-strain-in-epirubicin-induced-cardiotoxicity-in-patients-with-breast-cancer
#16
Wei-Ting Chang, Jhih-Yuan Shih, Yin-Hsun Feng, Chun-Yen Chiang, Yu Hsuan Kuo, Wei-Yu Chen, Hong-Chang Wu, Juei-Tang Cheng, Jhi-Joung Wang, Zhih-Cherng Chen
BACKGROUND: As cancer therapies have improved, patient life spans have been extended but quality of life has been threatened by chemotherapy induced cardiotoxicity. Most cardiac complications remain unobserved until specific symptoms develop. Speckle-tracking echocardiography is a sensitive imaging modality in detecting early occult myocardial dysfunction. METHODS: A total number of 35 patients newly diagnosed with breast cancer and preparing for epirubicin therapy were prospectively recruited...
September 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27701872/does-hepatitis-b-virus-infection-cause-breast-cancer
#17
Vishnu Prasad Adhikari, Lin-Jie Lu, Ling-Quan Kong
Lifestyle and family history are two of the most important risk factors for breast cancer (BC). However, these risk factors cannot explain the differences in the incidence and early BC onset among Chinese females compared to their western counterparts. We propose in this hypothesis the potential mechanism of indirect oncogenesis of hepatitis B virus (HBV) in causing BC through its persistence as occult infection and continuous replication with long term subtle liver damage. Estrogen is mainly deactivated in the liver and long term necro-inflammatory damage to liver may result in persistent high level of estrogen, which is a dominant risk factor for BC...
December 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27693810/first-case-of-roll-technique-for-mesorectal-recurrence-excision
#18
Lina Garcia, Luis Tresierra, Marjorie Garcerant, Hipolito Duran, Benedetto Ielpo, Eduardo Diaz, Isabel Fabra, Riccardo Caruso, Luis Malavé, Ana Bello, Susana Prados, Susana Tabernero, Yolanda Quijano, Emilio Vicente
The radio-guided occult lesion localization (ROLL) technique has been in use since the mid-1990s, mainly in breast surgery. Today, ROLL is used for numerous oncologic pathologies, including parathyroid lesions, melanomas, and colorectal tumors. We report a patient with an 11-mm left mesorectal solitary recurrence of a primary ovarian cancer in whom the ROLL technique was used to identify the implant. A radioisotope was introduced through a 22-gauge needle with endoscopic ultrasound technique using an linear echo endoscope...
January 1, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27685443/axillary-lymph-node-micrometastases-decrease-triple-negative-early-breast-cancer-survival
#19
G Houvenaeghel, R Sabatier, F Reyal, J M Classe, S Giard, H Charitansky, R Rouzier, C Faure, J R Garbay, E Daraï, D Hudry, P Gimbergues, R Villet, E Lambaudie
BACKGROUND: Triple-negative breast cancers (TNBCs) are the most deadly form of breast cancer (BC) subtypes. Axillary lymph node involvement (ALNI) has been described to be prognostic in BC taken as a whole, but its prognostic value in each subtype is unclear. We explored the prognostic impact of ALNI and especially of small size axillary metastases in early TNBCs. METHODS: We analysed in this multicentre study all patients treated for early TNBC in 12 French cancer centres...
October 25, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27685105/characteristics-of-quantitative-perfusion-parameters-on-dynamic-contrast-enhanced-mri-in-mammographically-occult-breast-cancer
#20
Jung Kyu Ryu, Sun Jung Rhee, Jeong Yoon Song, Soo Hyun Cho, Geon-Ho Jahng
The purpose of this study was to compare the characteristics of quantitative per-fusion parameters obtained from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in patients with mammographically occult (MO) breast cancers and those with mammographically visible (MV) breast cancers. Quantitative parameters (AUC, Ktrans, kep, ve, vp, and wi) from 13 MO breast cancers and 16 MV breast cancers were mapped after the DCE-MRI data were acquired. Various prog-nostic factors, including axillary nodal status, estrogen receptor (ER), progesterone receptor (PR), Ki-67, p53, E-cadherin, and human epidermal growth factor receptor 2 (HER2) were obtained in each group...
September 8, 2016: Journal of Applied Clinical Medical Physics
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