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Occult breast cancer

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https://www.readbyqxmd.com/read/29323551/gamma-imaging-guided-minimally-invasive-breast-biopsy-initial-clinical-experience
#1
Rachel F Brem, Anita K Mehta, Jocelyn A Rapelyea, Esma A Akin, Adriana M Bazoberry, Christel D Velasco
OBJECTIVE: The purpose of this study was to evaluate our initial experience with gamma imaging-guided vacuum-assisted breast biopsy in women with abnormal findings. MATERIALS AND METHODS: A retrospective review of patients undergoing breast-specific gamma imaging (BSGI), also known as molecular breast imaging (MBI), between April 2011 and October 2015 found 117 nonpalpable mammographically and sonographically occult lesions for which gamma imaging-guided biopsies were recommended...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29317040/molecular-breast-imaging-a-comprehensive-review
#2
Ashley I Huppe, Anita K Mehta, Rachel F Brem
Molecular breast imaging (MBI), also called breast-specific gamma imaging (BSGI), has been an integral component of our breast imaging practice for over a decade. Unlike mammography and ultrasound that are based on anatomy, MBI is a physiologic approach to breast cancer detection. MBI detects additional foci of occult breast cancer in 9.0% of women with newly diagnosed breast cancer, has a high sensitivity for detecting high-risk lesions, and detects 98% of invasive breast cancer and 91.0% of ductal carcinoma in situ...
February 2018: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29317037/the-role-of-ultrasound-in-breast-cancer-screening-the-case-for-and-against-ultrasound
#3
Jaime Geisel, Madhavi Raghu, Regina Hooley
Mammography is the gold standard for breast cancer screening. However, with increasing awareness among patients and health care providers of mammography limitations especially in dense breasts, supplemental screening for breast cancer with ultrasound and magnetic resonance imaging has been expanding. The roles of both in screening need to be re-examined. This article reviews the efficacy, utility, and feasibility of ultrasound as a screening tool for the early detection of occult breast cancer.
February 2018: Seminars in Ultrasound, CT, and MR
https://www.readbyqxmd.com/read/29303099/-cancer-detection-following-unprovoked-vte-case-history-and-physical-examination-are-still-of-foremost-importance
#4
G J Geersing
The relation between cancer and thrombosis is well known. In fact, the presence of an occult malignancy in patients with unprovoked venous thromboembolism (VTE) is named after a famous 19th century French physician; it is called Trousseau's sign. In this commentary, I elaborate upon findings from a recent individual patient data meta-analysis on Trousseau's sign. This study demonstrated that extensive screening to unmask an occult malignancy in unprovoked VTE is no better than 'simple' history taking and physical examination, alongside age-specific and gender-specific national cancer screening e...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29299762/risk-reduction-surgery-rrs-for-tubo-ovarian-cancer-in-an-irish-gynaecological-practice-an-analysis-of-indications-and-outcomes
#5
Claire Thompson, Ciara McCormick, Waseem Kamran, Ciaran O'Riain, Lucy Norris, David Gallagher, Noreen Gleeson
BACKGROUND: High-grade serous carcinoma (HGSC) is the most common tubo-ovarian cancer. The fallopian tube harbours the precursor lesion: serous tubal intraepithelial carcinoma (STIC). Bilateral salpingo-oophorectomy is an effective risk-reducing surgical (RRS) strategy for breast cancer susceptibility gene mutation carriers (BRCAm). The value of RRS in those without defined genetic risk is unknown but these women represent a substantial cohort in prophylactic surgical practice. METHODS: This is a retrospective review of RRS at an Irish university teaching hospital...
January 3, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29283437/analytic-survey-of-57-cases-of-oral-metastases
#6
Yingci Liu, Richard J Vargo, Elizabeth A Bilodeau
BACKGROUND: Oral lesions have been reported among the first signs of an undiagnosed metastatic disease. Accurate diagnosis of an occult metastasis remains critical in determining the treatment course. Previous studies regarding oral metastatic tumors present varied data regarding the most frequent metastases to the oral cavity. These discrepancies echo the changes in incidence rates for certain malignancies over time and demonstrate the need for periodic updates in oral metastasis studies...
December 28, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29279704/occult-breast-carcinoma-presenting-as-scalp-metastasis
#7
Ricardo L B Costa, Rubens B Costa-Filho, Marilin Rosa, Brian J Czerniecki
Breast cancer is the most common tumor among women, and approximately 6% of the patients have de novo metastatic breast cancer. Occult breast cancer accounts for only 0.1-0.8% of the cases and most commonly presents with axillary lymphadenopathy. Scalp metastases are rare and have been described as a sign of progression or widespread metastatic disease. Here, we describe a rare case of de novo metastatic breast cancer to the scalp as the single site of spread and without an identifiable primary breast tumor...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29246703/evaluation-of-discordance-in-primary-tumor-and-lymph-node-response-after-neoadjuvant-therapy-in-breast-cancer
#8
Christina A Fleming, Karen McCarthy, Ciara Ryan, Aoife McCarthy, Seamus O'Reilly, Deirdre O'Mahony, Tara Jane Browne, Paul Redmond, Mark A Corrigan
BACKGROUND: Neoadjuvant therapy (NAT) offers a unique opportunity to assess tumor response to systemic agents. However, a discrepancy may exist between the response of the primary tumor and involved nodes. We report on the frequency of response discordance after NAT in breast cancer. PATIENTS AND METHODS: All consecutive node-positive patients receiving NAT in our department from 2009 to 2014 were identified. Patient demographics, and radiologic and pathologic features were tabulated...
November 23, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29202610/occult-breast-cancer-in-breast-reduction-specimens
#9
Lotte Meyer, Camilla Bille, Thomas Foged, Anne Marie Bak Jylling
No abstract text is available yet for this article.
December 4, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29197686/the-impact-of-screening-on-cancer-incidence-and-mortality-in-missouri-usa-2004-2013
#10
Y Yoshida, C L Schmaltz, J Jackson-Thompson, E J Simoes
OBJECTIVES: Population-based evidence regarding impact of cancer screenings and cancer rates in Missouri is lacking. This study examined whether screenings of breast cancer, cervical cancer, and colorectal cancer impact early-stage cancer incidence and mortality in Missouri. STUDY DESIGN: This is an ecological study based on county-specific estimates of selected cancer screening prevalence and early-stage cancer incidence and cancer mortality. METHODS: County-specific prevalence of clinical breast examination, mammography, Pap test, sigmoidoscopy or colonoscopy, and fecal occult blood test (FOBT) were generated from Missouri County-Level Study (2003, 2007, and 2011)...
November 30, 2017: Public Health
https://www.readbyqxmd.com/read/29183534/papillary-breast-lesions-association-with-malignancy-and-upgrade-rates-on-surgical-excision
#11
Hanh-Tam Tran, Asma Mursleen, Sahar Mirpour, Omar Ghanem, Maen J Farha
Intraductal papilloma falls under the category of benign breast mass. However, recent studies show that it can harbor occult carcinoma. The management of benign intraductal papilloma remains controversial because of its nonspecific radiologic and histological findings, as well as its association with surrounding malignant pathology. The purpose of this study is to investigate upgrade rates of a benign intraductal papilloma on surgical excision and the need for surgical excision of papillary lesions diagnosed at core needle biopsy...
November 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29180879/male-occult-triple-negative-breast-cancer-with-dermatomyositis-a-case-report-and-review-of-the-literature
#12
Le Zhang, Chenghua Zhang, Zhaoying Yang, Miao He, Lijuan Zhang, Shereen Ezzat, Xi Liang
Occult breast cancer is defined by the presence of axillary metastases without an identifiable primary breast tumor. Here, we report a rare case of a male occult breast cancer with dermatomyositis. We performed a modified radical mastectomy consisting of whole breast mastectomy and axillary lymph node dissection. Immunohistochemistry and fluorescent in situ hybridization analyses demonstrated an adenocarcinoma likely of breast origin, which was an occult triple-negative breast cancer. Interestingly, the patient's previously noted periorbital dermatomyositis resolved promptly following surgical excision...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29176636/genetic-and-clinical-characteristics-in-japanese-hereditary-breast-and-ovarian-cancer-first-report-after-establishment-of-hboc-registration-system-in-japan
#13
Masami Arai, Shiro Yokoyama, Chie Watanabe, Reiko Yoshida, Mizuho Kita, Megumi Okawa, Akihiro Sakurai, Masayuki Sekine, Junko Yotsumoto, Hiroyuki Nomura, Yoshinori Akama, Mayuko Inuzuka, Tadashi Nomizu, Takayuki Enomoto, Seigo Nakamura
The hereditary breast and ovarian cancer (HBOC) registration system of Japan was established by the Japanese HBOC Consortium. The first trial was registered in 2015 in four institutions to which some registration committee members belonged. We analyzed the information of 830 Japanese pedigrees, who underwent BRCA1/2 genetic testing, including mutation carriers with BRCA1 (Nā€‰=ā€‰127) and BRCA2 (Nā€‰=ā€‰115), and their families. The mutation-positive rate was 19.7%. Variants of uncertain significance were found in 6...
November 8, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/29174225/diagnostic-accuracy-of-digital-breast-tomosynthesis-in-the-evaluation-of-palpable-breast-abnormalities
#14
Jeffrey R Hawley, Justine K Kang-Chapman, Sarah E Bonnet, Amy L Kerger, Clayton R Taylor, Barbaros S Erdal
RATIONALE AND OBJECTIVES: The role of digital breast tomosynthesis (DBT) in evaluating palpable abnormalities has not been evaluated and its accuracy compared to 2D mammography is unknown. The purpose of this study was to evaluate combined 2D mammography, DBT, and ultrasound (US) at palpable sites. MATERIALS AND METHODS: Two breast imagers reviewed blinded consecutive cases with combined 2D mammograms and DBT examinations performed for palpable complaints. By consensus, 2D and DBT findings were recorded and compared to US...
November 23, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29151972/comparable-survival-between-additional-radiotherapy-and-local-surgery-in-occult-breast-cancer-after-axillary-lymph-node-dissection-a-population-based-analysis
#15
San-Gang Wu, Wen-Wen Zhang, Jia-Yuan Sun, Feng-Yan Li, Huan-Xin Lin, Yong-Xiong Chen, Zhen-Yu He
Purpose: To investigate the clinical value of additional local treatment strategies in occult breast cancer (OBC) after axillary lymph node dissection (ALND). Methods: Patients diagnosed with OBC between 1990 and 2013 were included from the Surveillance, Epidemiology, and End Results registry database. The significant risk factors of cause-specific survival (CSS) and overall survival (OS) were identified using univariate and multivariate Cox regression analyses. Results: We identified 980 patients, including 219 (22...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29137058/anemia-and-thrombocytopenia-as-initial-symptoms-of-occult-breast-cancer-with-bone-marrow-metastasis-a-case-report
#16
Lulu Liu, Jingjing Zhang, Mingtai Chen, Saisai Ren, Haihui Liu, Hao Zhang
RATIONALE: Occult breast cancer (OBC) is a rare type of breast cancer without any symptoms in the breast and is often presented with initial symptoms of axillary lymph node metastasis or other metastases. The low incidence rates of OBC make it a great challenge to diagnose and cure. PATIENT CONCERNS: Our case was a 58-year-old female affected by dizziness and fatigue for nearly a month. Blood tests revealed anemia and thrombocytopenia, and pathological results of a bone marrow biopsy confirmed the metastatic carcinoma...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136697/-occult-breast-cancer-with-ipsilateral-axillary-and-cervical-lymph-node-metastasis-report-of-a-case
#17
J P Yuan, X X Yuan, L K Gao, H Wu, X X Yu, H L Yan
No abstract text is available yet for this article.
November 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29120813/visibility-of-mammographically-occult-breast-cancer-on-diffusion-weighted-mri-versus-ultrasound
#18
Nita Amornsiripanitch, Habib Rahbar, Averi E Kitsch, Diana L Lam, Brett Weitzel, Savannah C Partridge
PURPOSE: To investigate the visibility of mammographically occult breast cancers on diffusion-weighted MRI (DWI) versus ultrasound. MATERIALS AND METHODS: Mammographically occult breast cancers (n=60) initially detected on contrast-enhanced MRI that underwent pre-biopsy targeted ultrasound were retrospectively evaluated for visibility on DWI and ultrasound. RESULTS: More cancers were visible on DWI than ultrasound (78% vs. 63%; p=0.049), with 32 (53%) visible on both and 7 (12%) not visible on either...
October 28, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29110147/correction-to-villaret-syndrome-as-clinical-presentation-of-occult-metastatic-breast-cancer
#19
Luca Magistrelli, Claudia Varrasi, Alessandro Stecco, Alessandro Carriero, Roberto Cantello
The author's given name and family name were initially interchanged inadvertently. The correct names have been corrected above. The original article was corrected.
November 6, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29102440/patient-satisfaction-with-radioguided-occult-lesion-localisation-using-iodine-125-seeds-rollis-versus-conventional-hookwire-localisation
#20
Jeremy S L Ong, Joelin Teh, Christobel Saunders, Anita G Bourke, Catalina Lizama, Jade Newton, Michael Phillips, Donna B Taylor
BACKGROUND: Women with impalpable or poorly palpable breast cancer require radiologically guided localisation prior to breast conserving surgery. Radioguided Occult Lesion Localisation using Iodine-125 Seed (ROLLIS) is an emerging alternative to conventional Hookwire Localisation (HWL). We compared ROLLIS with conventional HWL with respect to patient reported stress and discomfort related to the localisation procedure. PATIENTS AND METHODS: From September 2013 to January 2016, women who were eligible for breast conserving surgery with impalpable or poorly palpable histologically confirmed invasive or in-situ carcinoma were recruited to the multi-centre ROLLIS randomised controlled trial and underwent either ROLLIS or HWL...
October 16, 2017: European Journal of Surgical Oncology
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