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Occult breast cancer

Carrie B Hruska
OBJECTIVE: The purposes of this review are to discuss the motivation for supplemental screening, to address molecular breast imaging (MBI) radiation dose concerns, and to provide an updated guide to current MBI technology, clinical protocols, and screening performance. Future directions of MBI are also discussed. CONCLUSION: MBI offers detection of mammographically occult cancers in women with dense breasts. Although MBI has been under investigation for nearly 15 years, it has yet to gain widespread adoption in breast screening...
October 20, 2016: AJR. American Journal of Roentgenology
A Collarino, R A Valdés Olmos, A F van der Hoeven, L M Pereira Arias-Bouda
PURPOSE: This review aims to discuss the methodological aspects of dedicated molecular breast imaging (MBI) using (99m)Tc-sestamibi as radiotracer to guide biopsy of occult or unclear breast lesions on mammography (MG) and ultrasound (US) that are suspicious on MBI (BI-RADS criteria 4 and 5), including its advantages, limitations and future clinical applications. METHODS: Literature search was performed using the PubMed/MEDLINE database and "(99m)Tc-sestamibi", "biopsy" and "breast cancer" as keywords...
2016: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
Katrina E Korhonen, Susan P Weinstein, Elizabeth S McDonald, Emily F Conant
Digital breast tomosynthesis (DBT) represents a valuable addition to breast cancer screening by decreasing recall rates while increasing cancer detection rates. The increased accuracy achieved with DBT is due to the quasi-three-dimensional format of the reconstructed images and the ability to "scroll through" breast tissue in the reconstructed images, thereby reducing the effect of tissue superimposition found with conventional planar digital mammography. The margins of both benign and malignant lesions are more conspicuous at DBT, which allows improved lesion characterization, increased reader confidence, and improved screening outcomes...
October 7, 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Wei-Ting Chang, Jhih-Yuan Shih, Yin-Hsun Feng, Chun-Yen Chiang, Yu Hsuan Kuo, Wei-Yu Chen, Hong-Chang Wu, Juei-Tang Cheng, Jhi-Joung Wang, Zhih-Cherng Chen
BACKGROUND: As cancer therapies have improved, patient life spans have been extended but quality of life has been threatened by chemotherapy induced cardiotoxicity. Most cardiac complications remain unobserved until specific symptoms develop. Speckle-tracking echocardiography is a sensitive imaging modality in detecting early occult myocardial dysfunction. METHODS: A total number of 35 patients newly diagnosed with breast cancer and preparing for epirubicin therapy were prospectively recruited...
September 2016: Acta Cardiol Sin
Vishnu Prasad Adhikari, Lin-Jie Lu, Ling-Quan Kong
Lifestyle and family history are two of the most important risk factors for breast cancer (BC). However, these risk factors cannot explain the differences in the incidence and early BC onset among Chinese females compared to their western counterparts. We propose in this hypothesis the potential mechanism of indirect oncogenesis of hepatitis B virus (HBV) in causing BC through its persistence as occult infection and continuous replication with long term subtle liver damage. Estrogen is mainly deactivated in the liver and long term necro-inflammatory damage to liver may result in persistent high level of estrogen, which is a dominant risk factor for BC...
September 12, 2016: Chinese Clinical Oncology
Lina Garcia, Luis Tresierra, Marjorie Garcerant, Hipolito Duran, Benedetto Ielpo, Eduardo Diaz, Isabel Fabra, Riccardo Caruso, Luis Malavé, Susana Prados, Susana Tabernero, Yolanda Quijano, Emilio Vicente
The radio guided occult lesion localization (ROLL) technique has been in use since the mid-90's, mainly in breast surgery. It is nowadays used for many oncological pathologies such as parathyroid lesions, melanoma, and colorectal tumors. We present the case of a patient with an 11 mm left meso rectal solitary recurrence of a primary ovarian cancer in whom the ROLL technique was used to identify the implant. The radio isotope was introduced with a 22g needle with Endoscopic ultrasound technique using an Echo lineal endoscope...
September 29, 2016: Journal of Minimally Invasive Gynecology
G Houvenaeghel, R Sabatier, F Reyal, J M Classe, S Giard, H Charitansky, R Rouzier, C Faure, J R Garbay, E Daraï, D Hudry, P Gimbergues, R Villet, E Lambaudie
BACKGROUND: Triple-negative breast cancers (TNBCs) are the most deadly form of breast cancer (BC) subtypes. Axillary lymph node involvement (ALNI) has been described to be prognostic in BC taken as a whole, but its prognostic value in each subtype is unclear. We explored the prognostic impact of ALNI and especially of small size axillary metastases in early TNBCs. METHODS: We analysed in this multicentre study all patients treated for early TNBC in 12 French cancer centres...
September 29, 2016: British Journal of Cancer
Jung Kyu Ryu, Sun Jung Rhee, Jeong Yoon Song, Soo Hyun Cho, Geon-Ho Jahng
The purpose of this study was to compare the characteristics of quantitative per-fusion parameters obtained from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in patients with mammographically occult (MO) breast cancers and those with mammographically visible (MV) breast cancers. Quantitative parameters (AUC, Ktrans, kep, ve, vp, and wi) from 13 MO breast cancers and 16 MV breast cancers were mapped after the DCE-MRI data were acquired. Various prog-nostic factors, including axillary nodal status, estrogen receptor (ER), progesterone receptor (PR), Ki-67, p53, E-cadherin, and human epidermal growth factor receptor 2 (HER2) were obtained in each group...
2016: Journal of Applied Clinical Medical Physics
Young Jae Lee, Shin Wha Lee, Kyu Rae Kim, Kyung Hae Jung, Jong Won Lee, Yong Man Kim
OBJECTIVE: Most BRCA1/2 carriers do not undergo risk-reducing salpingo-oophorectomy (RRSO) by the recommended age. This study aimed to find the incidence of precursor lesions and cancer after RRSO. METHODS: We retrospectively reviewed breast cancer patients identified as BRCA mutation carriers who underwent RRSO at Asan Medical Center, Seoul, Korea, from 2010 to 2014. From 2013, all cases were examined according to the Sectioning and Extensively Examining the Fimbria (SEE/FIM) protocol and underwent immunohistochemically staining...
August 8, 2016: Journal of Gynecologic Oncology
S C Hawkins, I Brown, P King, M El-Gammal, K Stepp, S Widdison, M Barta, N Jackson, P Drew
INTRODUCTION: Wire guided localisation (WGL) is the standard localisation technique for impalpable breast lesions. Radio-guided occult lesion localisation (ROLL) has been proposed as an alternative. We have been performing ROLL for therapeutic wide local excisions (WLE) and diagnostic excision biopsies (DEB) for the last 15 years. We present the largest reported consecutive series of ROLL excisions to date. PATIENTS AND METHODS: One thousand thirty nine consecutive patients who underwent ROLL for impalpable breast lesions were identified from a prospectively collected database...
September 9, 2016: European Journal of Surgical Oncology
Hiroshi Maruyama, Ryota Tanaka, Yasuhiro Fujisawa, Yasuhiro Nakamura, Shusaku Ito, Manabu Fujimoto
Cutaneous squamous cell carcinoma is the second common cutaneous cancer, especially in the elderly. Sentinel lymph node biopsy is generally performed in breast cancers and cutaneous melanomas to detect occult nodal metastases. The benefit of sentinel lymph node biopsy in improving cutaneous squamous cell carcinoma prognosis is doubtful. One hundred and sixty-nine patients who underwent treatment for cutaneous squamous cell carcinoma between 2004 and 2015, and who were followed up for at least 6 months or developed metastases within the follow-up period were included...
September 26, 2016: Journal of Dermatology
N Merali, M Yousuff, V Pronisceva, A Poddar
Paraneoplastic syndrome affects less than 1% of cancer patients. Diagnosis of paraneoplastic syndrome with neurological presentation requires screening for an underlying malignancy, including a complete history, physical examination and imaging studies. Treatment often results in symptom stability, rather than improvement. Paraneoplastic polymyositis can precede or instantaneously occur at diagnosis or treatment of a primary tumour, while neurological symptoms can persist even following cancer treatment. We report a rare case of metaplastic breast carcinoma with an unusual presentation of paraneoplastic polymyositis...
September 23, 2016: Annals of the Royal College of Surgeons of England
Jean M Weigert
To determine if the addition of breast ultrasound in women with dense breasts finds cancers that otherwise would have been obscured. Retrospective chart review from five sites from October 2009 through December 2013. Data included: number of screening mammograms; number of screening ultrasounds; Breast Imaging Reporting Data System code results; biopsy results including type of lesion, size, nuclear grade, receptor and node status, and patient demographic data. Year 1, 2,706 ultrasound with 151 biopsies yielded 11 cancers, positive predictive value (PPV) 7...
September 19, 2016: Breast Journal
Mae Zakhour, Yael Danovitch, Jenny Lester, B J Rimel, Christine S Walsh, Andrew J Li, Beth Y Karlan, Ilana Cass
OBJECTIVE: To report the frequency and features of occult carcinomas and the incidence of subsequent cancers following risk-reducing salpingo-oophorectomy (RRSO) in BRCA mutation carriers. METHODS: 257 consecutive women with germline BRCA mutations who underwent RRSO between January 1, 2000 and December 31, 2014 were identified in an Institutional Review Board approved study. All patients were asymptomatic with normal physical exams, CA 125 values, and imaging studies preoperatively, and had at least 12months of follow-up post-RRSO...
September 9, 2016: Gynecologic Oncology
Kalpana D Kariyappa, Francis Gnanaprakasam, Subhapradha Anand, Murali Krishnaswami, Madan Ramachandran
OBJECTIVE: To assess the role of contrast-enhanced dual-energy spectral mammogram (CEDM) as a problem-solving tool in equivocal cases. METHODS: 44 consenting females with equivocal findings on full-field digital mammogram underwent CEDM. All the images were interpreted by two radiologists independently. Confidence of presence was plotted on a three-point Likert scale and probability of cancer was assigned on Breast Imaging Reporting and Data System scoring. Histopathology was taken as the gold standard...
November 2016: British Journal of Radiology
S-E Chan, C-Y Liao, T-Y Wang, S-T Chen, D-R Chen, Y-J Lin, C-J Chen, H-K Wu, S-L Chen, S-J Kuo, C-W Lee, H-W Lai
BACKGROUND: The necessity of routine sub-nipple biopsy was uncertain, and the role of preoperative magnetic resonance imaging (MRI) in detecting nipple invasion in patients who have been selected for nipple sparing mastectomy (NSM) has not been adequately evaluated. METHODS: We retrospectively collected and analyzed the medical and surgical records of 434 patients with primary operable breast cancer who met the criteria for NSM and underwent breast surgery during the period January 2011 to December 2015...
August 22, 2016: European Journal of Surgical Oncology
Ann Thompson, Gail Santucci, Maureen Curcio
In newly diagnosed breast cancer patients, it has been shown that magnetic resonance imaging (MRI) detects additional cancer not found on mammography and thus is useful to map out the extent of disease in the affected breast.1 Others have shown MRI valuable in detecting occult disease in the contralateral breast.2 More recently, it has been reported that MRI is suitable for guiding surgical decisions, especially in younger women with lobular cancer and/ or increased breast density.3 Consequently, MRI is increasingly being used for clinical staging of breast cancer and is currently supported by the National Comprehensive Cancer Network (NCCN) to define the extent and/or multifocality of cancer in the ipsilateral breast, and to screen the contralateral breast at the time of initial diagnosis...
2016: Journal of Registry Management
Sara Giordano, Elizabeth Garrett-Mayer, Navdha Mittal, Kristin Smith, Lee Shulman, Carolyn Passaglia, William Gradishar, Mary Ellen Pavone
PURPOSE: Mutations in the BRCA1/2 genes are associated with breast and ovarian cancer susceptibility. Recent studies have suggested that the BRCA mutation might be associated with occult primary ovarian insufficiency. To evaluate fertility, several studies have validated anti-Mullerian hormone (AMH) as a direct biomarker for ovarian aging and it is considered a quantitative marker of ovarian reserve. We hypothesize that BRCA1 gene mutations will be negatively associated with AMH levels...
August 11, 2016: Journal of Adolescent and Young Adult Oncology
Marie Gosset, Anne-Sophie Hamy, Peter Mallon, Myriam Delomenie, Delphine Mouttet, Jean-Yves Pierga, Marick Lae, Alain Fourquet, Roman Rouzier, Fabien Reyal, Jean-Guillaume Feron
BACKGROUND: The poor prognosis of patients who experience ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery (BCS) is established. A short time between primary cancer and IBTR is a prognostic factor but no clinically relevant threshold was determined. Classification of IBTR may help tailor treatment strategies. PURPOSE: We determined a specific time frame, which differentiates IBTR into early and late recurrence, and identified prognostic factors for patients with IBTR at time of the recurrence...
2016: PloS One
Maryam Mousavinezhad, Reza Majdzadeh, Ali Akbari Sari, Alireza Delavari, Farideh Mohtasham
BACKGROUND: After lung and prostate cancers, colorectal cancer (CRC) is the third most common cancer in men and the second most common cancer in women after breast cancer worldwide. Every year, more than one million people are diagnosed with colorectal cancer worldwide and half of these patients die from this disease, making it the fourth leading cause of death in the world. This systematic review aimed to assess the effectiveness of the two colorectal diagnostic tests of FOBT (fecal occult blood test) and FIT (fecal immunochemical test)) in terms of technical performance...
2016: Medical Journal of the Islamic Republic of Iran
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