Maria Consiglia Trotta, Carlo Gesualdo, Marina Russo, Caterina Claudia Lepre, Francesco Petrillo, Maria Giovanna Vastarella, Maddalena Nicoletti, Francesca Simonelli, Anca Hermenean, Michele D'Amico, Settimio Rossi
Background and Objectives : The role and the levels of ghrelin in diabetes-induced retinal damage have not yet been explored. The present study aimed to measure the serum levels of total ghrelin (TG), and its acylated (AG) and des-acylated (DAG) forms in patients with the two stages of diabetic retinopathy (DR), non-proliferative (NPDR) and proliferative (PDR). Moreover, the correlation between serum ghrelin and neutrophil elastase (NE) levels was investigated. Materials and Methods : The serum markers were determined via enzyme-linked immunosorbent assays in 12 non-diabetic subjects (CTRL), 15 diabetic patients without DR (Diabetic), 15 patients with NPDR, and 15 patients with PDR...
January 8, 2024: Medicina