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Meenakshi Wadhwani, Praveen Vashist, Suraj Senjam Singh, Noopur Gupta, Pallavi Shukla, Amit Bhardwaj, Vivek Gupta
OBJECTIVES: To develop and implement a community-based program for screening of diabetic retinopathy (DR) in urban populations of Delhi. METHODS: Known diabetics (KDs) aged 40 years and older were identified through house-to-house surveys, volunteers and publicity. All KDs were referred to DR screening camps organised locally where procedures included brief medical history, ocular examination, and non-mydriatic fundus photography using portable handheld camera. Fundal images were graded on the spot by trained optometrists for diabetic retinopathy (DR)...
February 12, 2018: Tropical Medicine & International Health: TM & IH
Y Zhang, M Niu, Y Li, J Wang, B Qu, C X Zheng, P Huang, W H Yu
Objective: To analyze the prevalence and risk factors of diabetic retinopathy (DR) in ophthalmic patients. Methods: A cross-sectional study was performed. Diabetic patients who were admitted to Department of Ophthalmology, Traditional Chinese Medicine Hospital of Muping between October 2012 and June 2013 were included. General information and medical history were obtained from each subject by questionaires. Laboratory and detailed ophthalmic examinations were performed during the study. DR was diagnosed and graded by mydriatic fundus photography...
February 6, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Liyuan Peng, Bei Sun, Mingming Liu, Jing Huang, Yajin Liu, Zipeng Xie, Jinlong He, Liming Chen, Daowen Wang, Yi Zhu, Xu Zhang, Ding Ai
Diabetic retinopathy (DR) is the most frequent microvascular complications of diabetes and the leading cause of blindness in adults worldwide. Non-proliferative DR (NPDR) is the first stage of DR but currently has few recommended intervention. Eicosanoids play important roles in maintaining vessel homeostasis. However, the functions of eicosanoids in NPDR are still unknown. In this study, we investigated the eicosanoids profile difference in plasma between type 2 diabetes with NPDR or not. A total of 50 patients with type 2 diabetes were recruited and divided into non-DR (NDR) group and NPDR group based on fundus photographs...
February 1, 2018: Biochemical and Biophysical Research Communications
M D Pinazo-Durán, K Shoaie-Nia, S M Sanz-González, J Raga-Cervera, J J García-Medina, M I López-Gálvez, D Galarreta-Mira, L Duarte, C Campos-Borges, V Zanón-Moreno
OBJECTIVE: To identify genes involved in the pathogenic mechanisms of non-proliferative diabetic retinopathy (NPDR), among which include oxidative stress, extracellular matrix changes, and/or apoptosis, in order to evaluate the risk of developing this retinal disease in a type2 diabetic (DM2) population. MATERIAL AND METHODS: A case-control study was carried out on 81 participants from the Valencia Study on Diabetic Retinopathy (VSDR) of both genders, with ages 25-85years...
February 1, 2018: Archivos de la Sociedad Española de Oftalmología
Mahima Jhingan, Abhilash Goud, Hari Kumar Peguda, Mitali Khodani, Jeffrey K Luttrull, Jay Chhablani
Aim: To compare the outcomes of subthreshold microsecond (STM) and continuous-wave laser (CWL) panretinal photocoagulation (PRP). Methods: In this randomized, prospective, pilot study, 20 eyes of 10 subjects with symmetric severe non-proliferative (NPDR) or low-risk proliferative diabetic retinopathy (PDR) were included. Each eye of the subject was randomized into either CWL or STM PRP group. Patients were evaluated at baseline and at months 3, 6, and 9 with color fundus photographs and visual field tests at each visit; however, electroretinography (ERG) was conducted at baseline and at month 9...
2018: Clinical Ophthalmology
Bruna Letícia da Silva Pereira, Evelise Regina Polina, Daisy Crispim, Renan Cesar Sbruzzi, Luis Henrique Canani, Kátia Gonçalves Dos Santos
AIM: To investigate whether the -1082A>G polymorphism (rs1800896) in the interleukin-10 (IL10) gene is associated with diabetic retinopathy (DR) in Brazilians with type 2 diabetes mellitus. METHODS: This case-control study included 847 outpatients with type 2 diabetes and 145 healthy blood donors. Four hundred and two patients had no DR, 253 had non-proliferative DR (NPDR), and 192 had proliferative DR (PDR). Genotyping was done by real-time PCR. RESULTS: Genotype and allele frequencies were similar in patients and blood donors...
January 27, 2018: Diabetes Research and Clinical Practice
Yun-Yun Li, Xiu-Fen Yang, Hong Gu, Xi-Pu Liu, Torkel Snellingen, Ning-Pu Liu
AIM: To present the rationale, design, methodology, and the baseline data of the Beijing Desheng Diabetic Eye Study (BDDES), and to determine the prevalence of diabetic retinopathy (DR) and possible risk factors in patients with type 2 diabetes mellitus (T2DM) in an urban community of Beijing, China. METHODS: Community-based prospective cohort study of persons diagnosed with T2DM aged 30y or older. The main variables of interest are the presence and progression of DR as determined by the standardized ETDRS grading of seven fields fundus photographs...
2018: International Journal of Ophthalmology
Harpal Singh Sandhu, Nabila Eladawi, Mohammed Elmogy, Robert Keynton, Omar Helmy, Shlomit Schaal, Ayman El-Baz
BACKGROUND: Optical coherence tomography angiography (OCTA) is increasingly being used to evaluate diabetic retinopathy, but the interpretation of OCTA remains largely subjective. The purpose of this study was to design a computer-aided diagnostic (CAD) system to diagnose non-proliferative diabetic retinopathy (NPDR) in an automated fashion using OCTA images. METHODS: This was a two-centre, cross-sectional study. Adults with type II diabetes mellitus (DMII) were eligible for inclusion...
January 23, 2018: British Journal of Ophthalmology
Eva K Fenwick, Alfred Tl Gan, Ryan Eyn Kidd Man, Charumathi Sabanayagam, Preeti Gupta, Krystal Khoo, Amudha Aravindhan, Tien Y Wong, Ecosse L Lamoureux
IMPORTANCE: While consumption of soft drink may increase risk of cardiovascular disease, the relationship between soft drink consumption and diabetes complications is unknown. BACKGROUND: To explore the association between regular and diet soft drink consumption, and diabetic retinopathy (DR) and diabetic macular edema (DME). DESIGN: Clinical, cross-sectional study PARTICIPANTS: Adult patients with diabetes recruited from a tertiary eye hospital (Melbourne, Australia) answered a Food Frequency Questionnaire...
January 23, 2018: Clinical & Experimental Ophthalmology
Y Ding, Q Ge, H Qu, Z Feng, J Long, Q Wei, Q Zhou, R Wu, L Yao, H Deng
PURPOSE: To determine the association between serum periostin and the presence of diabetic retinopathy (DR). METHODS: Serum periostin was detected in 114 healthy subjects, 122 patients with type 2 diabetes mellitus (T2DM) and 159 patients with DR and compared among groups. Clinical data and other laboratory measurements such as glycated hemoglobin (HbA1c), lipid profiles, serum creatinine (Cr) and high-sensitivity CRP (hsCRP) were also collected and compared among groups...
January 18, 2018: Journal of Endocrinological Investigation
Abd-Rashid Suraida, Mohtar Ibrahim, Embong Zunaina
OBJECTIVES: To compare the anterior ocular segment biometry among Type 2 diabetes mellitus (DM) with no diabetic retinopathy (DR) and non-proliferative diabetic retinopathy (NPDR), and to evaluate the correlation of anterior ocular segment biometry with HbA1c level. METHODS: A cross-sectional study was conducted in Hospital Universiti Sains Malaysia, Kelantan from November 2013 till May 2016 among Type 2 DM patients (DM with no DR and DM with NPDR). The patients were evaluated for anterior ocular segment biometry [central corneal thickness (CCT), anterior chamber width (ACW), angle opening distance (AOD) and anterior chamber angle (ACA)] by using Anterior Segment Optical Coherence Tomography (AS-OCT)...
2018: PloS One
Mirinae Kim, Min Ji Ha, Seung Yong Choi, Young-Hoon Park
The relationships between changes in choroidal vasculature and the severity of diabetic retinopathy (DR) remain unclear. We assessed choroidal changes in diabetic patients by measuring choroidal vascularity index (CVI) in conjunction with DR stage. In this study, patients with diabetes and healthy controls were retrospectively analyzed. Subjects were divided into seven groups as follows: Healthy controls, no DR, mild/moderate non-proliferative DR (NPDR), severe NPDR, proliferative DR (PDR), panretinal photocoagulation-treated DR, and clinically significant macular edema...
January 8, 2018: Scientific Reports
Araniko Pandey, Gyanendra Lamichhane, Roshija Khanal, Salma K C Rai, Arjun Malla Bhari, Davide Borroni, Narayan Gautam
BACKGROUND: Diabetic retinopathy (DR) is one of the leading causes of preventable blindness in low and middle income countries. In Nepal, there are less studies regarding DR and they too are limited around Kathmandu valley. This study was done to assess visual morbidity in patients with DR at a peripheral tertiary eye care center of Nepal. METHODS: This was a prospective, hospital based, cross-sectional study in which all consecutive cases of DR were evaluated. DR was classified according to Early Treatment Diabetic Retinopathy Study Research Group - report no...
December 28, 2017: BMC Ophthalmology
Sangeetha Srinivasan, Cirous Dehghani, Nicola Pritchard, Katie Edwards, Anthony W Russell, Rayaz A Malik, Nathan Efron
Purpose: To examine the neuronal structural integrity of cornea and retina as markers for neuronal degeneration in nonproliferative diabetic retinopathy (NPDR). Methods: Participants were recruited from the broader Brisbane community, Queensland, Australia. Two hundred forty-one participants (187 with diabetes and 54 nondiabetic controls) were examined. Diabetic retinopathy (DR) was graded according to the Early Treatment Diabetic Retinopathy Study (ETDRS) scale...
December 1, 2017: Investigative Ophthalmology & Visual Science
Kiyoung Kim, Eung Suk Kim, Seung-Young Yu
AIM: To evaluate the correlation between inner retinal layer thinning and the foveal microvasculature in type 2 diabetes using optical coherence tomography angiography (OCTA). METHODS: A cross-sectional study involved 155 diabetic eyes. All patients were divided into two groups based on diabetic retinopathy (DR) grade: no DR (NDR, n=80) and mild-to-moderate non-proliferative DR (NPDR, n=75). Foveal avascular zone (FAZ) area, FAZ circularity index, FAZ perimeter, vessel density and perfusion index of parafoveal and perifoveal area were calculated using OCTA...
December 19, 2017: British Journal of Ophthalmology
Bhasker Mukherjee, Sandeep Shankar, Rehan Ahmed, Kanchan Singh, Kapil Bhatia
Introduction: India is presently facing an epidemic of diabetes mellitus and the risks of chronic complications from the disease are associated with the duration of the disease as well as the degree of hyperglycaemia. Diabetic retinopathy is a known microvascular complication of diabetes mellitus and is the most common cause of blindness in the western countries.Apolipoproteins are the protein component of lipoproteins. Apart from acting as structural proteins, they also act as cofactors to various enzymes...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
Keiji Yoshioka
INTRODUCTION: Advanced glycation end-products (AGEs) are known to play an important role in the pathogenesis of diabetic complications. Skin autofluorescence (AF), a marker of AGE accumulation in tissue, can be measured noninvasively using a skin AF reader. The present study aimed to evaluate the relationships of skin AF with diabetic microvascular complications and carotid intima-media thickness (IMT), a surrogate marker for atherosclerosis, in Japanese subjects with type 2 diabetes (T2D)...
November 24, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Chong Chen, Xia Chen, Hengye Huang, Changjing Han, Yuan Qu, Huiyi Jin, Tian Niu, Yuan Zhang, Kun Liu, Xun Xu
PURPOSE: To investigate the association of plasma and vitreous leucine-rich-α2-glycoprotein (LRG1) with diabetic retinopathy (DR) progression. METHODS: A total of 86 outpatients and 33 inpatients were recruited. Outpatients with type 2 diabetes mellitus (T2DM) were classified as T2DM without DR (n = 22), nonproliferative DR (NPDR) (n = 20) and proliferative DR (PDR) (n = 22) based on international clinical DR severity scales. A total of 86 plasma and 33 vitreous samples were collected and subjected to enzyme-linked immunosorbent assay...
November 23, 2017: Acta Ophthalmologica
Arnon Blum, Nina Pastukh, Dorina Socea, Hanin Jabaly
BACKGROUND: Proliferative diabetic retinopathy is a devastating complication of diabetes mellitus, developing within 15 years in 50% of patients with type 1 diabetes mellitus (DM) and in 10% of patients with type 2 DM. The correlation between levels of inflammatory markers in the peripheral blood and retinopathy staging has not been studied yet, and the purpose of this prospective study was to find a possible association between inflammation and staging of diabetic retinopathy. METHODS: A prospective (pilot) study that measured level of adhesion molecules in the peripheral blood of 10 healthy subjects and 30 patients with type 2 diabetes mellitus...
November 10, 2017: Cytokine
Joana Mesquita, João Paulo Castro de Sousa, Sara Vaz-Pereira, Arminda Neves, Paulo Tavares-Ratado, Fátima M Santos, Luís A Passarinha, Cândida T Tomaz
Vascular endothelial growth factor B (VEGF-B) is one of the enigmatic members of the VEGF family. The knowledge gap about VEGF-B expression and how its levels are altered in diabetic eyes were the focus of this investigation that was addressed by comparing and correlating vitreous VEGF-B between diabetic and non-diabetic patients. VEGF-B levels were measured by enzyme-linked immunosorbent assay in vitreous samples (n = 33) from diabetic (n = 25) and non-diabetic (n = 8) patients. Results were compared between groups...
August 9, 2017: Medical Sciences: Open Access Journal
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