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https://www.readbyqxmd.com/read/28429904/effect-of-lutein-supplementation-on-visual-function-in-nonproliferative-diabetic-retinopathy
#1
Ping-Chuan Zhang, Chang-Rui Wu, Zhi-Lun Wang, Li-Yuan Wang, Yue Han, Shu-Liu Sun, Qing-Shan Li, Le Ma
BACKGROUND AND OBJECTIVES: The purpose of this study was to determine whether supplementation with lutein improved visual function in patients with nonproliferative diabetic retinopathy (NPDR). METHODS AND STUDY DESIGN: In this randomized, double-blind, placebo-controlled trial, 31 patients with NPDR were assigned randomly to 10 mg/d of lutein or identical placebo for 36 weeks. Visual performance indices, including visual acuity (VA), contrast sensitivity (CS) and glare sensitivity (GS) at four different spatial frequencies, were measured at baseline, week 18 and 36...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28420575/correlation-of-various-serum-biomarkers-with-the-severity-of-diabetic-retinopathy
#2
M Nalini, B V Raghavulu, A Annapurna, P Avinash, Vishala Chandi, N Swathi, Wasim
Hyperglycemia induced inflammation and angiogenic factors are implicated as a contributor to the onset and progression of diabetic retinopathy (DR) in type 2 diabetes mellitus patients (T2DM). Tumor necrosis factor (TNF-alpha) and C-reactive protein (CRP) are inflammatory cytokines which induce retinal VEGF and are involved in the progression of proliferative diabetic retinopathy (PDR). Therefore the aim of the present study is to investigate the relationship between diabetic retinopathy and systemic inflammation in patients with type 2 diabetes mellitus...
April 8, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28403072/retinal-microvascular-alterations-related-to-diabetes-assessed-by-optical-coherence-tomography-angiography-a-cross-sectional-analysis
#3
Julien Gozlan, Pierre Ingrand, Olivier Lichtwitz, Agathe Cazet-Supervielle, Léa Benoudis, Michele Boissonnot, Samy Hadjadj, Nicolas Leveziel
Fluorescein angiography has been so far the gold-standard test to assess diabetic macular ischemia (DMI), a cause of irreversible visual impairment in diabetic patients. The aim of this study was to investigate foveal avascular zone (FAZ) and perifoveal microcirculation changes in eyes with nonproliferative diabetic retinopathy (NPDR) using optical coherence tomography angiography (OCTA), a new and noninvasive vascular imaging technique.Cross-sectional study including eyes of diabetic patients with NPDR.All patients underwent medical history, best-corrected visual acuity (BCVA) measurement, slit-lamp and fundus examination, multicolor imaging, SD-OCT, and swept-source OCT...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28387229/assessment-of-conjunctival-microvascular-hemodynamics-in-stages-of-diabetic-microvasculopathy
#4
Maziyar M Khansari, Justin Wanek, Michael Tan, Charlotte E Joslin, Jacob K Kresovich, Nicole Camardo, Norman P Blair, Mahnaz Shahidi
Diabetes impairs the microcirculation and function of various vital tissues throughout the body. The conjunctival microcirculation can be non-invasively imaged and thus enables assessment of microvascular hemodynamics. In this study, alterations in conjunctival microvascular hemodynamics were quantitatively assessed at stages of increasing diabetic microvasculopathy based on diabetic retinopathy (DR). Subjects were categorized into non-diabetic control (C, N = 34), no clinically visible DR (NDR, N = 47), non-proliferative DR (NPDR, N = 45), and proliferative DR (PDR, N = 35)...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28367202/effect-of-topical-nepafenac-in-prevention-of-macular-edema-after-cataract-surgery-in-patients-with-non-proliferative-diabetic-retinopathy
#5
Muhammad Haroon Sarfraz, Rana Intisar Ul Haq, Mohammad Asim Mehboob
OBJECTIVE: To determine the efficacy of topical Nepafenac (0.1%), administered post-operatively in prevention of Macular Edema (ME), after cataract surgery in patients with Non-Proliferative Diabetic Retinopathy (NPDR). METHODS: This randomized control trial was conducted at Armed Forces Institute of Ophthalmology (AFIO), Rawalpindi from Sep 2015 to Sep 2016. Sixty eyes of 60 patients with NPDR underwent phacoemulsification with intraocular lens implantation. Group 1 received 0...
January 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28362051/deep-capillary-macular-perfusion-indices-obtained-with-oct-angiography-correlate-with-degree-of-nonproliferative-diabetic-retinopathy
#6
Kumar Sambhav, Khaled K Abu-Amero, Kakarla V Chalam
PURPOSE: To evaluate the integrity of macular and temporomacular vasculature in nonproliferative diabetic retinopathy (NPDR) with noninvasive optical coherence tomography angiography (OCTA) and correlate perfusion indices with degree of NPDR. METHODS: In this prospective observational cross-sectional study, 102 eyes with newly diagnosed NPDR (mild NPDR, 36; moderate NPDR, 21; severe NPDR, 13; NPDR with diabetic macular edema [DME], 32) underwent OCTA. Sixty eyes of normal subjects served as control...
March 27, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28355247/effects-of-photocoagulation-on-ocular-blood-flow-in-patients-with-severe-non-proliferative-diabetic-retinopathy
#7
Takeshi Iwase, Misato Kobayashi, Kentaro Yamamoto, Eimei Ra, Hiroko Terasaki
PURPOSE: To investigate ocular blood flow and correlations between ocular blood flow and variables in patients with severe non-proliferative diabetic retinopathy (S-NPDR) following panretinal photocoagulation (PRP). METHODS: In this retrospective, cross-sectional study, the blood flow on the optic nerve head (ONH) and choroid was assessed with laser speckle flowgraphy (LSFG) using the mean blur rate (MBR) in 76 eyes of 76 patients with S-NPDR who underwent PRP, 39 eyes of 39 patients with S-NPDR who did not undergo PRP, and 71 eyes of 71 normal subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28336215/association-of-increased-levels-of-mcp-1-and-cathepsin-d-in-young-onset-type-2-diabetes-patients-t2dm-y-with-severity-of-diabetic-retinopathy
#8
Sruthi Reddy, Anandakumar Amutha, Ramachandran Rajalakshmi, Regin Bhaskaran, Finny Monickaraj, Sampathkumar Rangasamy, Ranjit Mohan Anjana, Shiny Abhijit, Kuppan Gokulakrishnan, Arup Das, Viswanathan Mohan, Muthuswamy Balasubramanyam
AIM: Young onset type 2 diabetes patients (T2DM-Y) have been shown to possess an increased risk of developing microvascular complications particularly diabetic retinopathy. However, the molecular mechanisms are not clearly understood. In this study, we investigated the serum levels of monocyte chemotactic protein 1 (MCP-1) and cathepsin-D in patients with T2DM-Y without and with diabetic retinopathy. METHODS: In this case-control study, participants comprised individuals with normal glucose tolerance (NGT=40), patients with type 2 diabetes mellitus (T2DM=35), non-proliferative diabetic retinopathy (NPDR=35) and proliferative diabetic retinopathy (PDR=35)...
May 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28336057/hemorrhage-and-or-microaneurysm-severity-and-count-in-ultrawide-field-images-and-early-treatment-diabetic-retinopathy-study-photography
#9
Paolo S Silva, Hala El-Rami, Rasha Barham, Aditi Gupta, Alan Fleming, Jano van Hemert, Jerry D Cavallerano, Jennifer K Sun, Lloyd Paul Aiello
OBJECTIVE: To evaluate detection of hemorrhage and/or microaneurysm (H/Ma) using ultrawide field (UWF) retinal imaging as compared with standard Early Treatment Diabetic Retinopathy Study (ETDRS) 7-field photographs (ETDRS photos). DESIGN: Single-site comparative study of UWF images and ETDRS photos. PARTICIPANTS: One hundred twenty-six eyes of 69 patients with no diabetic retinopathy (DR) or mild or moderate nonproliferative DR (NPDR). METHODS: Stereoscopic 200° UWF images and stereoscopic 35mm 30° 7-field color photographs were acquired on the same visit...
March 20, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28333883/quantification-of-retinal-vessel-tortuosity-in-diabetic-retinopathy-using-optical-coherence-tomography-angiography
#10
Hyungwoo Lee, Minsub Lee, Hyewon Chung, Hyung Chan Kim
PURPOSE: To investigate the association of vessel tortuosity with severity of diabetic retinopathy (DR) using optical coherence tomography angiography. METHODS: We retrospectively analyzed 30 healthy eyes and 121 eyes of diabetic subjects with no DR, mild nonproliferative DR (NPDR), moderate to severe NPDR and proliferative DR (PDR). Binarized images were used to quantify the vessel tortuosity, vessel density, foveal avascular zone (FAZ) area, and FAZ acircularity...
March 22, 2017: Retina
https://www.readbyqxmd.com/read/28332564/pupillary-responses-in-non-proliferative-diabetic-retinopathy
#11
Jason C Park, Yi-Fan Chen, Norman P Blair, Felix Y Chau, Jennifer I Lim, Yannek I Leiderman, Mahnaz Shahidi, J Jason McAnany
The goal of this study was to determine the extent of rod-, cone-, and melanopsin-mediated pupillary light reflex (PLR) abnormalities in diabetic patients who have non-proliferative diabetic retinopathy (NPDR). Fifty diabetic subjects who have different stages of NPDR and 25 age-equivalent, non-diabetic controls participated. PLRs were measured in response to full-field, brief-flash stimuli under conditions that target the rod, cone, and intrinsically-photosensitive (melanopsin) retinal ganglion cell pathways...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299499/evaluation-of-vitreous-levels-of-advanced-glycation-end-products-and-angiogenic-factors-as-biomarkers-for-severity-of-diabetic-retinopathy
#12
Makiko Katagiri, Jun Shoji, Noriko Inada, Satoshi Kato, Shigehiko Kitano, Yasuko Uchigata
BACKGROUND/AIMS: Glyceraldehyde-derived advanced glycation end products (glycer-AGE; also called Toxic-AGE [TAGE]) play a crucial role in the pathogenesis of diabetic angiopathy. However, the relationships between vitreous glycer-AGE levels and diabetic retinopathy (DR) severity, and between glycer-AGE levels and the levels of other angiogenic factors remain unknown. We investigated the correlation between levels of vitreous biomarkers, including glycer-AGE and angiogenic factors (vascular endothelial growth factor [VEGF], interleukin [IL]-8, leptin, placental growth factor [PlGF], endoglin, and fibroblast growth factor [FGF]-2) in patients with DR, using three DR staging groups...
March 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28279572/association-of-serum-levels-of-anti-myeloperoxidase-antibody-with-retinal-photoreceptor-ellipsoid-zone-disruption-in-diabetic-retinopathy
#13
Shivani Sinha, Sandeep Saxena, Senthamizh Prasad, Abbas Ali Mahdi, Shashi Kumar Bhasker, Siddharth Das, Vladimir Krasnik, Martin Caprnda, Radka Opatrilova, Peter Kruzliak
AIM: To study the association of serum levels of anti-myeloperoxidase (MPO) antibody with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy. METHODS: Consecutive patients with type 2 DM [diabetes mellitus with no retinopathy (NODR; n=20); non-proliferative diabetic retinopathy (NPDR; n=18); proliferative diabetic retinopathy (PDR; n=16)] and healthy controls (n=20) between the ages of 40 and 65years were included. Disruption of EZ was graded by spectral domain optical coherence tomography as no disruption of EZ and disrupted EZ...
May 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28277285/bevacizumab-and-panretinal-photocoagulation-protect-against-ocular-hypertension-after-posterior-subtenon-injection-of-triamcinolone-acetonide-for-diabetic-macular-edema
#14
Yi-Ting Hsieh, Chung-May Yang, Shu-Hui Chang
BACKGROUND/PURPOSE: To analyze the prognostic factors for ocular hypertension after posterior subtenon injection of triamcinolone acetonide (PSTA) for the treatment of diabetic macular edema (DME). METHODS: Patients who received PSTA for DME from January 2006 to December 2011 were enrolled retrospectively and were followed until December 2012 in one hospital. Modified Cox regression models were used to analyze the factors associated with ocular hypertension, which was defined as an intraocular pressure>21 mmHg after PSTA...
October 27, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28245487/mitochondrial-haplogroups-affect-severity-but-not-prevalence-of-diabetic-retinopathy
#15
Jana A Bregman, David J Herren, Christopher B Estopinal, Isaac M Chocron, Paula A Harlow, Cassandra Warden, Milam A Brantley, David C Samuels
Purpose: We previously reported European mitochondrial haplogroup H to be a risk factor for and haplogroup UK to be protective against proliferative diabetic retinopathy (PDR) among Caucasian patients with diabetic retinopathy (DR). The purpose of this study was to determine whether these haplogroups are also associated with the risk of having DR among Caucasian patients with diabetes. Methods: Deidentified medical records for 637 Caucasian patients with diabetes (223 with DR) were obtained from BioVU, Vanderbilt University's electronic, deidentified DNA databank...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28238189/retinal-neurodegeneration-in-patients-with-type-1-diabetes-mellitus-the-role-of-glycemic-variability
#16
Fabiana Picconi, Mariacristina Parravano, Dorina Ylli, Patrizio Pasqualetti, Sara Coluzzi, Ilaria Giordani, Ilaria Malandrucco, Davide Lauro, Fabio Scarinci, Paola Giorno, Monica Varano, Simona Frontoni
AIMS: Recent studies have identified neuroretinal abnormalities in persons affected by diabetes mellitus, before the onset of microvascular alterations. However, the role of glycemic variability (GV) on early retinal neurodegeneration is still not clarified. METHODS: To explore the relationship between glycemic control and neuroretinal characteristics, 37 persons with Type 1 diabetes mellitus (Type 1 DM) divided into two groups with no signs (noRD) and with mild non-proliferative diabetic retinopathy (NPDR) compared to 13 healthy control participants (C) were recruited...
May 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28212983/acircularity-index-and-axis-ratio-of-the-foveal-avascular-zone-in-diabetic-eyes-and-healthy-controls-measured-by-optical-coherence-tomography-angiography
#17
Brian D Krawitz, Shelley Mo, Lawrence S Geyman, Steven A Agemy, Nicole K Scripsema, Patricia M Garcia, Toco Y P Chui, Richard B Rosen
Given the complexity of the current system used to stage diabetic retinopathy (DR) and the risks and limitations associated with intravenous fluorescein angiography (IVFA), noninvasive quantification of DR severity is desirable. We examined the utility of acircularity index and axis ratio of the foveal avascular zone (FAZ), metrics that can noninvasively quantify the severity of diabetic retinopathy without the need for axial length to correct for individual retinal magnification. A retrospective review was performed of type 2 diabetics and age-matched controls imaged with optical coherence tomography angiography (OCTA)...
February 26, 2017: Vision Research
https://www.readbyqxmd.com/read/28196053/choroidal-thickness-in-diabetic-retinopathy-assessed-with-swept-source-optical-coherence-tomography
#18
Inês Laíns, Katherine E Talcott, Ana R Santos, João H Marques, Pedro Gil, João Gil, João Figueira, Deeba Husain, Ivana K Kim, Joan W Miller, Rufino Silva, John B Miller
PURPOSE: To compare the choroidal thickness (CT) of diabetic eyes (different stages of disease) with controls, using swept-source optical coherence tomography. METHODS: A multicenter, prospective, cross-sectional study of diabetic and nondiabetic subjects using swept-source optical coherence tomography imaging. Choroidal thickness maps, according to the nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, were obtained using automated software. Mean CT was calculated as the mean value within the ETDRS grid, and central CT as the mean in the central 1 mm...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28194551/changes-in-choroidal-thickness-in-patients-with-diabetic-retinopathy
#19
Zaigen Ohara, Hitoshi Tabuchi, Shunsuke Nakakura, Yuki Yoshizumi, Hitomi Sumino, Yukiko Maeda, Yoshiaki Kiuchi
PURPOSE: To investigate the changes in choroidal thickness (ChT) following panretinal photocoagulation (PRP) for diabetic retinopathy (DR) and compare ChT in relation to DR severity. METHODS: Thirty-two eyes [19 eyes with proliferative DR (PDR) and 13 eyes with severe nonproliferative DR (NPDR)] for which PRP was necessary were analyzed. ChT was measured before PRP and at 1, 3, and 6 months after PRP using the swept-source optical coherence tomography. ChT of the 61 eyes matched with the PDR patients for the mean age and axial length was also measured and statistically compared in relation to severity...
February 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28137601/genome-wide-mrna-analysis-reveals-a-tubd1-isoform-profile-as-a-potential-biomarker-for-diabetic-retinopathy-development
#20
Vanessa Villegas-Ruiz, Ferdinand Hendlmeier, Beatriz Buentello-Volante, José L Rodríguez-Loaiza, Antonio Miranda-Duarte, Juan C Zenteno
Diabetic retinopathy (DR) affects approximately one third of all diabetic subjects and is the leading cause of blindness in young to middle-aged adults in the developed world. While early diagnosis is crucial for preventing DR-associated visual loss, the identification of accessible biomarkers that could lead to presymptomatic recognition of the disease is of great clinical importance. The aim of this work was to investigate the possible involvement of alternative splicing events in DR development by performing a genome-wide transcriptional profiling comparing blood-derived RNA from DR subjects and from diabetic-non DR controls...
January 27, 2017: Experimental Eye Research
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