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Sven-Erik Bursell, Stephanie J Fonda, Drew G Lewis, Mark B Horton
BACKGROUND: Diabetes and its complications are more common in American Indians and Alaska Natives (AI/AN) than other US racial/ethnic populations. Prior reports of diabetic retinopathy (DR) prevalence in AI/AN are dated, and research on diabetic macular edema (DME) is limited. This study characterizes the recent prevalence of DR and DME in AI/AN using primary care-based teleophthalmology surveillance. METHODS: This is a multi-site, clinic-based, cross-sectional study of DR and DME...
2018: PloS One
Ji Hyun Lee, Ju Hee Han, Kyung Do Han, Young Min Park, Jun Young Lee, Yong-Gyu Park, Young Bok Lee
Psoriasis is a chronic cutaneous disease known to be related with systemic disease; however, the association between psoriasis and diabetic complications has not been previously reported. Diabetic microvascular complications include diabetic retinopathy (DR), nephropathy, and neuropathy, and overt diabetic nephropathy can lead to the end-stage renal disease (ESRD).The present study investigated the association between psoriasis and non-proliferative DR (NPDR) or proliferative DR (PDR) or ESRD. We analyzed the relationship between diabetic complication and psoriasis using data from the National Health Insurance Service between 2009 and 2015...
June 14, 2018: Scientific Reports
Liang Li, Pu Zhang, Hong Liu, Yu-Hua Liu, Ling Gao
PURPOSE: To investigate multispectral imaging (MSI) as a novel diagnostic approach for diabetic retinopathy (DR) in clinic. METHODS: A total of 50 Type-2 diabetic patients (99 eyes) were enrolled in this cross-sectional study. All subjects underwent digital fundus photography (DFP), MSI, and fundus fluorescein angiography. A total exact agreement, sensitivity, specificity, positive predictive value, and negative predictive value of no DR/mild nonproliferative diabetic retinopathy (NPDR) and severe NPDR/proliferative diabetic retinopathy (PDR) grading were calculated based on DFP and MSI and were compared with fundus fluorescein angiography...
June 12, 2018: Retina
Peige Song, Jinyue Yu, Kit Yee Chan, Evropi Theodoratou, Igor Rudan
Background: Diabetic retinopathy (DR), the primary retinal vascular complication of diabetes mellitus (DM), is a leading cause of vision impairment and blindness in working-age population globally. Despite mounting concerns about the emergence of DM as a major public health problem in the largest developing country, China, much remains to be understood about the epidemiology of DR. We aimed to investigate the prevalence of and risk factors for DR, and estimate the burden of DR in China in 2010...
June 2018: Journal of Global Health
Ma Ludivina Robles-Osorio, Renata García-Franco, Carlos D Núñez-Amaro, Ximena Mira-Lorenzo, Paulina Ramírez-Neria, Wendy Hernández, Ellery López-Star, Thomas Bertsch, Gonzalo Martínez de la Escalera, Jakob Triebel, Carmen Clapp
Background: Diabetic retinopathy (DR) and diabetic macular edema (DME) are potentially blinding, microvascular retinal diseases in people with diabetes mellitus. Preclinical studies support a protective role of the hormone prolactin (PRL) due to its ocular incorporation and conversion to vasoinhibins, a family of PRL fragments that inhibit ischemia-induced retinal angiogenesis and diabetes-derived retinal vasopermeability. Here, we describe the protocol of an ongoing clinical trial investigating a new therapy for DR and DME based on elevating the circulating levels of PRL with the prokinetic, dopamine D2 receptor blocker, levosulpiride...
2018: Frontiers in Endocrinology
Jin-Song Zhao, Hui-Xiang Jin, Jia-Lin Gao, Chun Pu, Peng Zhang, Jian-Jun Huang, Long Cheng, Gang Feng
Extracellular superoxide dismutase (ecSOD) is the major extracellular scavenger of reactive oxygen species and associated with the diabetic complication in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the serum ecSOD activity in Chinese patients with different stages of diabetic retinopathy (DR) and evaluate the association between the serum ecSOD activity and the severity of DR. A total of 343 T2DM patients were categorized into three groups: nondiabetic retinopathy (NDR) group, nonproliferative diabetic retinopathy (NPDR) group, and proliferative diabetic retinopathy (PDR) group...
2018: Disease Markers
J Jason McAnany, Jason C Park
Purpose: To evaluate explanations for contrast sensitivity (CS) losses in subjects who have mild nonproliferative diabetic retinopathy (NPDR) or no diabetic retinopathy (NDR) by measuring and modeling CS in luminance noise. Methods: Ten diabetic subjects with NDR, 10 with mild NPDR, and 10 age-equivalent nondiabetic controls participated. Contrast threshold energy (Et) was measured for letters presented in the absence of noise (Et0) and in four levels of luminance noise...
May 1, 2018: Investigative Ophthalmology & Visual Science
Sharanjeet-Kaur, Siti-Aishah Ismail, Haliza Abdul Mutalib, Nor Fariza Ngah
PURPOSE: The purpose of this study was to determine the relationship between HbA1c values and retinal sensitivity at central 10° using the MP-1 microperimeter. METHODS: A prospective study was carried out on 32 healthy subjects (control group) and 60 diabetic patients. The diabetic patients were divided into 2 groups. Group 1 comprised of 30 patients without diabetic retinopathy (DR) and group 2 had 30 patients with mild non-proliferative DR. A full-threshold microperimetry of the central 10° of retina (the macula) was performed on all subjects, utilizing 32 points with the MP-1...
May 26, 2018: Journal of Optometry
Zhen Liang, Kai P Gao, Yi X Wang, Zi C Liu, Li Tian, Xin Z Yang, Jing Y Ding, Wei T Wu, Wen H Yang, Yi L Li, Ze B Zhang, Ri H Zhai
Diabetic retinopathy (DR) is the leading cause of blindness in patients with diabetes. However, biomarkers for early detection of DR are still lacking. MicroRNAs (miRNAs) regulate multiple biological functions and are often deregulated in DR. We aimed to investigate whether circulating miRNAs can be used as biomarkers of early-stage DR. We used RNA-seq and qRT-PCR to identify differential serum miRNAs in patients with type 2 diabetes mellitus with DR (T2DM-DR), T2DM without DR (T2DM-no-DR), and healthy controls...
May 29, 2018: American Journal of Physiology. Endocrinology and Metabolism
Felipe F Conti, Vivian L Qin, Eduardo B Rodrigues, Sumit Sharma, Aleksandra V Rachitskaya, Justis P Ehlers, Rishi P Singh
BACKGROUND/AIMS: Split-spectrum amplitude decorrelation angiography for spectral-domain optical coherence tomography has enabled detailed, non-invasive assessment of vascular flow. This study evaluates choriocapillaris and retinal capillary perfusion density (CPD) in diabetic eyes using optical coherence tomography angiography (OCTA). METHODS: Records of 136 eyes that underwent OCTA imaging at a single institution were reviewed. Eyes were grouped as non-diabetic controls (37 eyes), patients with diabetes mellitus (DM) without diabetic retinopathy (DM without DR, 31 eyes), non-proliferative diabetic retinopathy (NPDR, 41 eyes) and proliferative diabetic retinopathy (PDR, 27 eyes)...
May 23, 2018: British Journal of Ophthalmology
Jiman Kim, Eulsun Moon, Tae-Hun Kim
Diabetic retinopathy (DR) is one of the leading cause of blindness worldwide and the most common cause of blindness among the working population. Early treatment of the disease is essential to prevent severe visual loss among patients. But there are few therapeutic options available for early stage diabetic retinopathy. We present the case of an early stage diabetic retinopathy patient presented with retinal hemorrhages in the superior temporal area and disc hemorrhages of disc nasal area. The patient was diagnosed with mild NPDR on fundus examinations...
April 24, 2018: Explore: the Journal of Science and Healing
Hiroaki Endo, Satoru Kase, Mitsuo Takahashi, Masahiko Yokoi, Chisato Isozaki, Satoshi Katsuta, Manabu Kase
IMPORTANCE: Choroidal thickness changes in diabetic retinopathy improve the understanding of the pathophysiology and managements of this disease. BACKGROUND: To examine the choroidal layer thickness in diabetes mellitus (DM) patients and normal individuals, and to compare the findings based on medical history of systemic DM treatments, and stage of diabetic retinopathy (DR). DESIGN: Case control study. PARTICIPANTS: Two hundred and sixty-eight eyes of 134 DM patients and age-matched 72 healthy controls of 92 eyes...
May 9, 2018: Clinical & Experimental Ophthalmology
Ceying Shen, Shu Yan, Min Du, Hong Zhao, Ling Shao, Yibo Hu
BACKGROUND: To assess capillary dropout in the superficial retinal capillary plexus (SCP) by optical coherence tomography angiography (OCTA) in the early stage of diabetic retinopathy (DR). METHODS: This study was a cross-sectional observational study. Patients that underwent OCTA examinations in our hospital between November 2015 and May 2016 were included in the study. The subjects were divided into two groups: A) normal controls (41 eyes of 41 subjects) and B) the DR patients (49 eyes of 49 patients with mild non-proliferative DR (NPDR))...
May 8, 2018: BMC Ophthalmology
Yansha Lu, Joseph M Simonett, Jie Wang, Miao Zhang, Thomas Hwang, Ahmed M Hagag, David Huang, Dengwang Li, Yali Jia
Purpose: To describe an automated algorithm to quantify the foveal avascular zone (FAZ), using optical coherence tomography angiography (OCTA), and to compare its performance for diagnosis of diabetic retinopathy (DR) and association with best-corrected visual acuity (BCVA) to that of extrafoveal avascular area (EAA). Methods: We obtained 3 × 3-mm macular OCTA scans in diabetic patients with various levels of DR and healthy controls. An algorithm based on a generalized gradient vector flow (GGVF) snake model detected the FAZ, and metrics assessing FAZ size and irregularity were calculated...
May 1, 2018: Investigative Ophthalmology & Visual Science
Takao Hirano, Jyunya Kitahara, Yuichi Toriyama, Hirotsugu Kasamatsu, Toshinori Murata, Srinivas Sadda
AIMS: To evaluate quantitative metrics of the retinal microvasculature in eyes with diabetic retinopathy (DR) using various en face swept-source optical coherence tomography angiography (SS-OCTA) image sizes. METHODS: Non-segmented and segmented images were acquired using an SS-OCTA device (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA). The scanning protocols included the 3×3 mm, 6×6 mm and 12×12 mm fields of view. Quantitative analysis of the perfusion density (PD), vessel length density (VLD) and fractal dimension (FD) was performed...
April 29, 2018: British Journal of Ophthalmology
Rajeev K R Pappuru, Luísa Ribeiro, Conceição Lobo, Dalila Alves, José Cunha-Vaz
AIM: To analyse retinopathy phenotypes and microaneurysm (MA) turnover in mild non-proliferative diabetic retinopathy (NPDR) as predictors of progression to diabetic central-involved macular oedema (CIMO) in patients with type 2 diabetes mellitus (DM) in two different ethnic populations. METHODS: 205 patients with type 2 DM and mild NPDR were followed in a prospective observational study for 2 years or until development of CIMO, in two centres from different regions of the world...
April 26, 2018: British Journal of Ophthalmology
Minhaj Alam, Taeyoon Son, Devrim Toslak, Jennifer I Lim, Xincheng Yao
Purpose: This study aims to develop a fully automated algorithm for artery-vein (A-V) and arteriole-venule classification and to quantify the effect of hypertension on A-V caliber and tortuosity ratios of nonproliferative diabetic retinopathy (NPDR) patients. Methods: We combine an optical density ratio (ODR) analysis and blood vessel tracking (BVT) algorithm to classify arteries and veins and arterioles and venules. An enhanced blood vessel map and ODR analysis are used to determine the blood vessel source nodes...
April 2018: Translational Vision Science & Technology
Qi Chen, Fan Tan, Yufei Wu, Xiran Zhuang, Chaoming Wu, Yuheng Zhou, Yingzi Li, Dan Cheng, Jianhua Wang, Fan Lu, Meixiao Shen
Purpose: To investigate early retinal structural and microvascular changes in patients with type 2 diabetes mellitus (DM) and to analyze relationships among the retinal structure, microvasculature, and choroid. Methods: Seventy-seven patients with type 2 DM (40 with no diabetic retinopathy [DR], 37 with nonproliferative diabetic retinopathy [NPDR]), and 34 control subjects were enrolled. Spectral-domain optical coherence tomography, operating in radial 18-line mode, obtained macular images of the eight intraretinal layers and the choroid...
April 1, 2018: Investigative Ophthalmology & Visual Science
Jianqin Lei, Enhui Yi, Yan Suo, Cheng Chen, Xiayu Xu, Wenxiang Ding, Nizar Saleh Abdelfattah, Xiaojuan Fan, Huiqin Lu
Purpose: To quantify and evaluate macular superficial capillaries and large vessels separately using an optical coherence tomographic angiography (OCTA)-based automatic segmentation algorithm. Methods: In this cross-sectional study, all eyes were scanned using an OCTA device with 3 × 3 mm cube centered on the fovea. Retinal large vessels (arterioles/venules) were automatically segmented from superficial vasculature en-face images. All images were normalized, binarized, and skeletonized for quantification...
April 1, 2018: Investigative Ophthalmology & Visual Science
Rui Shi, Lei Zhao, Yun Qi
BACKGROUND: Previous studies suggested that use of fenofibrate could significantly reduce the rate of progression into diabetic retinopathy (DR), and that retinal nerve fiber layer (RNFL) loss, which has been considered an important indicator for retinal neurodegeneration, might precede microvascular changes. The aim of this study was to assess the effect(s) of fenofibrate on RNFL thickness at early stage of DR in patients with type 2 diabetes mellitus (DM). METHODS: In this retrospective matched case-control study we included a cohort of 89 patients with type 2 DM, aged 40 or above, between Jan 1, 2017 and March 31, 2017...
April 18, 2018: BMC Ophthalmology
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