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https://www.readbyqxmd.com/read/29023169/associations-of-physical-activity-and-sedentary-behaviour-with-vision-threatening-diabetic-retinopathy-in-indonesian-population-with-type-2-diabetes-mellitus-jogjakarta-eye-diabetic-study-in-the-community-joged-com
#1
D P Dharmastuti, A N Agni, F Widyaputri, S Pawiroranu, Z M Sofro, F S Wardhana, S Haryanto, T W Widayanti, S Kotha, P Gupta, M B Sasongko
PURPOSE: To investigate the association of physical activity (PA) and sedentary behaviour with diabetic retinopathy (DR) in type 2 diabetes adults. METHODS: A community-based cross-sectional study of adults with type 2 diabetes. DR was assessed from disc- and macula-centred fundus photograph, and categorised into mild, moderate non-proliferative DR (NPDR), and Vision-Threatening DR (VTDR). Worse eye was used to determine the person's DR severity. PA was assessed using WHO Global Physical Activity Questionnaire (GPAQ)...
October 12, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29022954/agreement-on-diabetic-retinopathy-grading-in-fundus-photographs-by-allied-ophthalmic-personnel-as-compared-to-ophthalmologist-at-a-community-setting-in-nepal
#2
Raba Thapa, Sanyam Bajimaya, Eli Pradhan, Govinda Paudyal
INTRODUCTION: Diabetic retinopathy (DR) is the emerging cause of blindness in the developing world. Timely detection of DR could save vision from its avoidable blinding condition. OBJECTIVE: To assess the accuracy of DR grading in fundus photographs by the allied ophthalmic personnel (AOP) as compared to ophthalmologist at a community setting in Nepal. MATERIALS AND METHODS: Fundus photographs of known diabetes subjects attending for DR screening were graded by two groups of AOP and ophthalmologist...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28988899/diabetic-choroidopathy-choroidal-vascular-density-and-volume-in-diabetic-retinopathy-with-swept-source-optical-coherence-tomography
#3
Jay C Wang, Inês Laíns, Joana Providência, Grayson W Armstrong, Ana R Santos, Pedro Gil, João Gil, Katherine E Talcott, João H Marques, João Figueira, Demetrios G Vavvas, Ivana K Kim, Joan W Miller, Deeba Husain, Rufino Silva, John B Miller
PURPOSE: To compare choroidal vascular density (CVD) and volume (CVV) in diabetic eyes and controls, using en face swept-source optical coherence tomography (SS-OCT). DESIGN: Prospective cross-sectional study. METHODS: ▪▪▪ SETTING: Multicenter PATIENT POPULATION: 143 diabetic eyes - 27 with no diabetic retinopathy (DR), 47 with nonproliferative DR (NPDR), 51 with NPDR and diabetic macular edema (DME), and 18 with proliferative DR (PDR), and 64 age-matched non-diabetic control eyes...
October 5, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28979738/role-of-angiopoietins-and-tie-2-in-diabetic-retinopathy
#4
Nervana Khalaf, Hazem Helmy, Hany Labib, Iman Fahmy, Mona Abd El Hamid, Leqaa Moemen
OBJECTIVE: The aim of this study was to determine the serum levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), soluble vascular endothelial tyrosine kinase receptor (Tie-2) and vascular endothelial growth factor (VEGF), in the serum of type 2 diabetic patients having non-proliferative (NPDR) or proliferative diabetic retinopathy (PDR). METHODS: One hundred patients with type 2 diabetes mellitus were involved in this cross-sectional study. They were classified into 25 diabetic patients without retinopathy, 35 patients with NPDR and 40 PDR patients...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28973335/optical-coherence-tomography-angiography-reveals-spatial-bias-of-macular-capillary-dropout-in-diabetic-retinopathy
#5
Yoshihiro Kaizu, Shintaro Nakao, Shigeo Yoshida, Takehito Hayami, Mitsuru Arima, Muneo Yamaguchi, Iori Wada, Toshio Hisatomi, Yasuhiro Ikeda, Tatsuro Ishibashi, Koh-Hei Sonoda
Purpose: Our purpose is to evaluate the spatial bias of macular capillary dropout accompanying diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). Methods: This study included 47 patients with diabetes and 29 healthy individuals who underwent OCTA. Retinal capillary flow density (FD) of 2.6 × 2.6 or 5.2 × 5.2 mm foveal area as well as the four divided areas (superior, inferior, temporal, nasal) without a foveal avascular zone (FAZ) at the superficial capillary plexus and deep capillary plexus (DCP) were measured respectively using ImageJ and NI Vision...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28973314/multidimensional-functional-and-structural-evaluation-reveals-neuroretinal-impairment-in-early-diabetic-retinopathy
#6
Katherine A Joltikov, Vinicius M de Castro, Jose R Davila, Rohit Anand, Sami M Khan, Neil Farbman, Gregory R Jackson, Chris A Johnson, Thomas W Gardner
Purpose: To test whether quantitative functional tests and optical coherence tomography (OCT)-defined structure can serve as effective tools to diagnose and monitor early diabetic neuroretinal disease. Methods: Fifty-seven subjects with diabetes (23 without diabetic retinopathy [no DR], 19 with mild nonproliferative diabetic retinopathy [mild NPDR], 15 with moderate to severe [moderate NPDR]), and 18 controls underwent full ophthalmic examination, fundus photography, spectral-domain optical coherence tomography (SD-OCT), e-ETDRS (Early Treatment Diabetic Retinopathy Study) acuity, and the quick contrast sensitivity function (qCSF) method...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28964682/association-of-functional-snp-1562c-t-in-mmp9-promoter-with-proliferative-diabetic-retinopathy-in-north-indian-type-2-diabetes-mellitus-patients
#7
Kanhaiya Singh, Prabhjot Goyal, Manju Singh, Sujit Deshmukh, Divyesh Upadhyay, Sri Kant, Neeraj K Agrawal, Sanjeev K Gupta, Kiran Singh
OBJECTIVE: Retinal angiogenesis is a hallmark of diabetic retinopathy. Matrix Metalloproteinases (MMPs) are involved in degradation of extracellular matrix (ECM). Functional SNP-1562C>T in the promoter of the MMP-9 gene results increase in transcriptional activity. The present work was designed to evaluate the contribution of functional SNP-1562C>T of MMP-9 gene to the risk of proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM) patients in north Indian Population...
August 26, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28937857/evaluation-of-retinal-blood-flow-before-and-after-panretinal-photocoagulation-using-pattern-scan-laser-for-diabetic-retinopathy
#8
Yoshihisa Yamada, Kiyoshi Suzuma, Naoko Onizuka, Masafumi Uematsu, Yasser Helmy Mohamed, Takashi Kitaoka
PURPOSE: Laser speckle flowgraphy (LSFG) can measure blood flow in the ocular fundus. We analyzed the relationship between retinal blood flow and panretinal photocoagulation (PRP) in diabetic retinopathy. METHODS: This retrospective observational study examined the eyes of 35 patients with proliferative diabetic retinopathy (PDR) or non-PDR (NPDR). PRP was performed using a pattern scan laser. Using LSFG, blood flow was evaluated as the mean blur rate (MBR) or the relative flow volume (RFV)...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28930746/early-assessment-of-the-risk-factors-for-diabetic-retinopathy-can-reduce-the-risk-of-peripheral-arterial-and-cardiovascular-diseases-in-type-2-diabetes
#9
Juan Tang, Tao Li, Pinhong Li, Yuefei Ma, Momo Liu, Qiaoyun Shan, Fengqi Guo, Ting Zhou, Qianping Wei
BACKGROUNDS: There is still a lack of consensus about how to assess the risk of peripheral arterial disease (PAD) and cardiovascular disease (CVD) in patients with diabetic retinopathy (DR). AIMS: We investigated the risk factors for DR and their association with PAD and CVD in patients with type 2 diabetes (T2D). METHODS: A total of 1,421 patients diagnosed with T2D participated in this study. DR stages were classified as non-DR, nonproliferative DR (NPDR), or proliferative DR (PDR)...
September 21, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28924157/normal-to-mildly-increased-albuminuria-predicts-the-risk-for-diabetic-retinopathy-in-patients-with-type-2-diabetes
#10
Min-Kyung Lee, Kyung-Do Han, Jae-Hyuk Lee, Seo-Young Sohn, Oak-Kee Hong, Jee-Sun Jeong, Mee-Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
Albuminuria is closely associated with diabetic retinopathy (DR), but the precise role of the albumin-to-creatinine ratio (ACR) in screening for DR remains to be determined. This study aimed to investigate an ACR threshold for predicting DR in patients with type 2 diabetes. A cross-sectional study was conducted on 1,102 type 2 diabetes patients, aged ≥30 years and recruited from the Korea National Health and Nutrition Examination Survey, 2010-2011. Participants were grouped by stage of DR: mild-to-moderate nonproliferative DR (NPDR), severe NPDR, and proliferative diabetic retinopathy (PDR)...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28860696/telemedicine-for-diabetic-retinopathy-screening-using-an-ultra-widefield-fundus-camera
#11
Nazimul Hussain, Maryam Edraki, Rima Tahhan, Nishanth Sanalkumar, Sami Kenz, Nagwa Khalil Akasha, Brian Mtemererwa, Nahed Mohammed
OBJECTIVE: Telemedicine reporting of diabetic retinopathy (DR) screening using ultra-widefield (UWF) fundus camera. MATERIALS AND METHODS: Cross-sectional study of diabetic patients who visited the endocrinology department of a private multi-specialty hospital in United Arab Emirates between April 2015 and January 2017 who underwent UWF fundus imaging. Fundus pictures are then accessed at the Retina Clinic in the Department of Ophthalmology. Primary outcome measure was incidence of any form of DR detected...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28820921/analysis-of-cone-mosaic-reflectance-properties-in-healthy-eyes-and-in-eyes-with-nonproliferative-diabetic-retinopathy-over-time
#12
Letizia Mariotti, Nicholas Devaney, Giuseppe Lombardo, Marco Lombardo
Purpose: We investigate the reflectance properties of the cone mosaic in adaptive optics (AO) images of healthy subjects and subjects with nonproliferative diabetic retinopathy (NPDR) over time. Methods: We acquired images of the parafoveal cone mosaic over 5 years in 12 healthy subjects and in six patients with mild NPDR. We analyzed the parameters of the cone intensity histogram distribution (mean, SD, and skewness), two metrics of the cone mosaic texture (sharpness and entropy), and two novel metrics (cone/intercone intensity and slope of the variogram)...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28810572/diffusion-weighted-imaging-of-injuries-to-the-visual-centers-of-the-brain-in-patients-with-type-2-diabetes-and-retinopathy
#13
Ming Liang, Xing Chen, Feng Xue, Lingna Meng, Yunfeng Cong
The present study aimed to investigate the ability of diffusion-weighted imaging (DWI) to identify injury to the visual centers of the brain in patients with type 2 diabetes with retinopathy. The study included 84 cases (63 patients with type 2 diabetic retinopathy and 21 healthy individuals) that were assessed using DWI. Diabetic patients were equally divided into three groups: Proliferative diabetic retinopathy (PDR), non-proliferative diabetic retinopathy (NPDR) and diabetic without retinopathy. The results demonstrated that individuals in the PDR group had significantly higher disease duration and glycated hemoglobin levels than the diabetic without retinopathy group (P<0...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28805196/-the-evaluation-of-color-vision-and-its-diagnostic-value-in-predicting-the-risk-of-diabetic-retinopathy-in-patients-with-glucose-metabolism-disorders
#14
Katarzyna Jończyk-Skórka, Jan Kowalski
AIM: The aim of the study was to evaluate color vision and its diagnostic value in predicting the risk of diabetic retinopathy in patients with glucose metabolism disorders. MATERIALS AND METHODS: The study involved 197 people, 92 women and 105 men aged 63.21 ± 8.74 years. In order to assess glucose metabolism disorders, patients were divided into three groups. The first group (DM) consisted of 60 people (16 women and 44 men aged 61.92 ± 8.46 years). These were people with type 2 diabetes...
July 21, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28790784/a-clinical-correlation-of-conjunctival-microangiopathy-with-grades-of-retinopathy-in-type-2-diabetes-mellitus
#15
M A Khan, Manasa Katta, V S Gurunadh, P S Moulick, Sandeep Gupta, Alok Sati
BACKGROUND: Conjunctival microangiopathy has been described among diabetics similar to retinal vessel angiopathy. Correlation of these conjunctival microangiopathy changes with retinopathy may form the basis of screening by external examination without expert fundus evaluation. METHODS: Conjunctival vessels widths and tortuous segment length of conjunctival vessels of 96 patients with type 2 diabetes mellitus were photographed and measured by the Zeiss Fundus camera Visupac software...
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28767589/effects-of-fenofibrate-on-inflammatory-cytokines-in-diabetic-retinopathy-patients
#16
Hai-Bing Ju, Fu-Xian Zhang, Shuang Wang, Jie Song, Tao Cui, Li-Feng Li, Hai-Yan Zhang
The role of cytokines in diabetic retinopathy (DR) and effects of fenofibrate on cytokines were explored by observing changes in serum IL-1β, TNF-α, VEGF, and Lp-PLA2 in different stages of DR and the intervention effect of oral fenofibrate on cytokines.In total, 190 patients with type 2 DR were enrolled and divided into 3 groups: diabetic without retinopathy (NDR) group (n = 30), nonproliferative diabetic retinopathy (NPDR) group (n = 80), and proliferative diabetic retinopathy (PDR) group (n = 80)...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28761661/association-of-diabetic-retinopathy-with-both-sarcopenia-and-muscle-quality-in-patients-with-type-2-diabetes-a-cross-sectional-study
#17
Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
OBJECTIVE: To examine whether the existence and severity of diabetic retinopathy (DR) could be associated with the prevalent sarcopenia and muscle quality in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: This is a cross-sectional study of 316 patients with type 2 diabetes (mean age 65±12 years; 38% female). Body compositions were measured by the dual-energy X-ray absorptiometry. Patients were divided into three groups: patients without DR (NDR), with non-proliferative DR (NPDR) and proliferative DR (PDR)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28758129/the-association-of-haptoglobin-gene-variants-and-retinopathy-in-type-2-diabetic-patients-a-meta-analysis
#18
REVIEW
Huiqun Wu, Huan Wu, Lili Shi, Xinlu Yuan, Ying Yin, Mingjie Yuan, Yushan Zhou, Qianwen Hu, Kui Jiang, Jiancheng Dong
AIMS/INTRODUCTION: To collectively evaluate the association between haptoglobin (Hp) gene variants and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). METHODS: A comprehensive literature review was performed for eligible studies. After inclusion and exclusion selection as well as quality assessment, those studies meeting quality standards were included. In this study, diabetic patients with retinopathy were selected as the case group and those ones without DR were treated as the control group...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28750414/retinal-vessel-geometry-and-the-incidence-and-progression-of-diabetic-retinopathy
#19
Laurence S Lim, Miao Li Chee, Carol Y Cheung, Tien Yin Wong
Purpose: To analyze the associations between retinal vessel geometry and the 1-year incidence and progression of diabetic retinopathy (DR) in a Chinese population. Methods: This was a prospective cohort study of adult subjects with diabetes mellitus. Retinal vascular geometry was quantified from fundus photographs using a semiautomated computer-assisted program. Diabetic retinopathy was graded from retinal photographs at baseline and 1 year. Incident DR and 2-step change in DR were analyzed...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28750218/insulin-resistance-correlates-with-maculopathy-and-severity-of-retinopathy-in-young-adults-with-type-1-diabetes-mellitus
#20
C W Rowe, A S Haider, D Viswanathan, M Jones, J Attia, K Wynne, S Acharya
AIMS: To assess the relationship between insulin resistance (IR), retinopathy and maculopathy in young adults with Type 1 diabetes mellitus. METHODS: A cross-sectional study at a regional Australian tertiary hospital. Retinal pathology, assessed by colour fundus photography, was correlated with two surrogate measures of IR: estimated Glucose Disposal Rate (eGDR) and Insulin Sensitivity Score (ISS), where lower scores reflect greater IR. RESULTS: 107 patients were recruited, with mean age 24...
June 27, 2017: Diabetes Research and Clinical Practice
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