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https://www.readbyqxmd.com/read/28336215/association-of-increased-levels-of-mcp-1-and-cathepsin-d-in-young-onset-type-2-diabetes-patients-t2dm-y-with-severity-of-diabetic-retinopathy
#1
Sruthi Reddy, Anandakumar Amutha, Ramachandran Rajalakshmi, Regin Bhaskaran, Finny Monickaraj, Sampathkumar Rangasamy, Ranjit Mohan Anjana, Shiny Abhijit, Kuppan Gokulakrishnan, Arup Das, Viswanathan Mohan, Muthuswamy Balasubramanyam
AIM: Young onset type 2 diabetes patients (T2DM-Y) have been shown to possess an increased risk of developing microvascular complications particularly diabetic retinopathy. However, the molecular mechanisms are not clearly understood. In this study, we investigated the serum levels of monocyte chemotactic protein 1 (MCP-1) and cathepsin-D in patients with T2DM-Y without and with diabetic retinopathy. METHODS: In this case-control study, participants comprised individuals with normal glucose tolerance (NGT=40), patients with type 2 diabetes mellitus (T2DM=35), non-proliferative diabetic retinopathy (NPDR=35) and proliferative diabetic retinopathy (PDR=35)...
March 10, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28336057/hemorrhage-and-or-microaneurysm-severity-and-count-in-ultrawide-field-images-and-early-treatment-diabetic-retinopathy-study-photography
#2
Paolo S Silva, Hala El-Rami, Rasha Barham, Aditi Gupta, Alan Fleming, Jano van Hemert, Jerry D Cavallerano, Jennifer K Sun, Lloyd Paul Aiello
OBJECTIVE: To evaluate detection of hemorrhage and/or microaneurysm (H/Ma) using ultrawide field (UWF) retinal imaging as compared with standard Early Treatment Diabetic Retinopathy Study (ETDRS) 7-field photographs (ETDRS photos). DESIGN: Single-site comparative study of UWF images and ETDRS photos. PARTICIPANTS: One hundred twenty-six eyes of 69 patients with no diabetic retinopathy (DR) or mild or moderate nonproliferative DR (NPDR). METHODS: Stereoscopic 200° UWF images and stereoscopic 35mm 30° 7-field color photographs were acquired on the same visit...
March 20, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28333883/quantification-of-retinal-vessel-tortuosity-in-diabetic-retinopathy-using-optical-coherence-tomography-angiography
#3
Hyungwoo Lee, Minsub Lee, Hyewon Chung, Hyung Chan Kim
PURPOSE: To investigate the association of vessel tortuosity with severity of diabetic retinopathy (DR) using optical coherence tomography angiography. METHODS: We retrospectively analyzed 30 healthy eyes and 121 eyes of diabetic subjects with no DR, mild nonproliferative DR (NPDR), moderate to severe NPDR and proliferative DR (PDR). Binarized images were used to quantify the vessel tortuosity, vessel density, foveal avascular zone (FAZ) area, and FAZ acircularity...
March 22, 2017: Retina
https://www.readbyqxmd.com/read/28332564/pupillary-responses-in-non-proliferative-diabetic-retinopathy
#4
Jason C Park, Yi-Fan Chen, Norman P Blair, Felix Y Chau, Jennifer I Lim, Yannek I Leiderman, Mahnaz Shahidi, J Jason McAnany
The goal of this study was to determine the extent of rod-, cone-, and melanopsin-mediated pupillary light reflex (PLR) abnormalities in diabetic patients who have non-proliferative diabetic retinopathy (NPDR). Fifty diabetic subjects who have different stages of NPDR and 25 age-equivalent, non-diabetic controls participated. PLRs were measured in response to full-field, brief-flash stimuli under conditions that target the rod, cone, and intrinsically-photosensitive (melanopsin) retinal ganglion cell pathways...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299499/evaluation-of-vitreous-levels-of-advanced-glycation-end-products-and-angiogenic-factors-as-biomarkers-for-severity-of-diabetic-retinopathy
#5
Makiko Katagiri, Jun Shoji, Noriko Inada, Satoshi Kato, Shigehiko Kitano, Yasuko Uchigata
BACKGROUND/AIMS: Glyceraldehyde-derived advanced glycation end products (glycer-AGE; also called Toxic-AGE [TAGE]) play a crucial role in the pathogenesis of diabetic angiopathy. However, the relationships between vitreous glycer-AGE levels and diabetic retinopathy (DR) severity, and between glycer-AGE levels and the levels of other angiogenic factors remain unknown. We investigated the correlation between levels of vitreous biomarkers, including glycer-AGE and angiogenic factors (vascular endothelial growth factor [VEGF], interleukin [IL]-8, leptin, placental growth factor [PlGF], endoglin, and fibroblast growth factor [FGF]-2) in patients with DR, using three DR staging groups...
March 15, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28279572/association-of-serum-levels-of-anti-myeloperoxidase-antibody-with-retinal-photoreceptor-ellipsoid-zone-disruption-in-diabetic-retinopathy
#6
Shivani Sinha, Sandeep Saxena, Senthamizh Prasad, Abbas Ali Mahdi, Shashi Kumar Bhasker, Siddharth Das, Vladimir Krasnik, Martin Caprnda, Radka Opatrilova, Peter Kruzliak
AIM: To study the association of serum levels of anti-myeloperoxidase (MPO) antibody with retinal photoreceptor ellipsoid zone (EZ) disruption in diabetic retinopathy. METHODS: Consecutive patients with type 2 DM [diabetes mellitus with no retinopathy (NODR; n=20); non-proliferative diabetic retinopathy (NPDR; n=18); proliferative diabetic retinopathy (PDR; n=16)] and healthy controls (n=20) between the ages of 40 and 65years were included. Disruption of EZ was graded by spectral domain optical coherence tomography as no disruption of EZ and disrupted EZ...
February 28, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28277285/bevacizumab-and-panretinal-photocoagulation-protect-against-ocular-hypertension-after-posterior-subtenon-injection-of-triamcinolone-acetonide-for-diabetic-macular-edema
#7
Yi-Ting Hsieh, Chung-May Yang, Shu-Hui Chang
BACKGROUND/PURPOSE: To analyze the prognostic factors for ocular hypertension after posterior subtenon injection of triamcinolone acetonide (PSTA) for the treatment of diabetic macular edema (DME). METHODS: Patients who received PSTA for DME from January 2006 to December 2011 were enrolled retrospectively and were followed until December 2012 in one hospital. Modified Cox regression models were used to analyze the factors associated with ocular hypertension, which was defined as an intraocular pressure>21 mmHg after PSTA...
October 27, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28245487/mitochondrial-haplogroups-affect-severity-but-not-prevalence-of-diabetic-retinopathy
#8
Jana A Bregman, David J Herren, Christopher B Estopinal, Isaac M Chocron, Paula A Harlow, Cassandra Warden, Milam A Brantley, David C Samuels
Purpose: We previously reported European mitochondrial haplogroup H to be a risk factor for and haplogroup UK to be protective against proliferative diabetic retinopathy (PDR) among Caucasian patients with diabetic retinopathy (DR). The purpose of this study was to determine whether these haplogroups are also associated with the risk of having DR among Caucasian patients with diabetes. Methods: Deidentified medical records for 637 Caucasian patients with diabetes (223 with DR) were obtained from BioVU, Vanderbilt University's electronic, deidentified DNA databank...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28238189/retinal-neurodegeneration-in-patients-with-type-1-diabetes-mellitus-the-role-of-glycemic-variability
#9
Fabiana Picconi, Mariacristina Parravano, Dorina Ylli, Patrizio Pasqualetti, Sara Coluzzi, Ilaria Giordani, Ilaria Malandrucco, Davide Lauro, Fabio Scarinci, Paola Giorno, Monica Varano, Simona Frontoni
AIMS: Recent studies have identified neuroretinal abnormalities in persons affected by diabetes mellitus, before the onset of microvascular alterations. However, the role of glycemic variability (GV) on early retinal neurodegeneration is still not clarified. METHODS: To explore the relationship between glycemic control and neuroretinal characteristics, 37 persons with Type 1 diabetes mellitus (Type 1 DM) divided into two groups with no signs (noRD) and with mild non-proliferative diabetic retinopathy (NPDR) compared to 13 healthy control participants (C) were recruited...
February 25, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28212983/acircularity-index-and-axis-ratio-of-the-foveal-avascular-zone-in-diabetic-eyes-and-healthy-controls-measured-by-optical-coherence-tomography-angiography
#10
Brian D Krawitz, Shelley Mo, Lawrence S Geyman, Steven A Agemy, Nicole K Scripsema, Patricia M Garcia, Toco Y P Chui, Richard B Rosen
Given the complexity of the current system used to stage diabetic retinopathy (DR) and the risks and limitations associated with intravenous fluorescein angiography (IVFA), noninvasive quantification of DR severity is desirable. We examined the utility of acircularity index and axis ratio of the foveal avascular zone (FAZ), metrics that can noninvasively quantify the severity of diabetic retinopathy without the need for axial length to correct for individual retinal magnification. A retrospective review was performed of type 2 diabetics and age-matched controls imaged with optical coherence tomography angiography (OCTA)...
February 26, 2017: Vision Research
https://www.readbyqxmd.com/read/28196053/choroidal-thickness-in-diabetic-retinopathy-assessed-with-swept-source-optical-coherence-tomography
#11
Inês Laíns, Katherine E Talcott, Ana R Santos, João H Marques, Pedro Gil, João Gil, João Figueira, Deeba Husain, Ivana K Kim, Joan W Miller, Rufino Silva, John B Miller
PURPOSE: To compare the choroidal thickness (CT) of diabetic eyes (different stages of disease) with controls, using swept-source optical coherence tomography. METHODS: A multicenter, prospective, cross-sectional study of diabetic and nondiabetic subjects using swept-source optical coherence tomography imaging. Choroidal thickness maps, according to the nine Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, were obtained using automated software. Mean CT was calculated as the mean value within the ETDRS grid, and central CT as the mean in the central 1 mm...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28194551/changes-in-choroidal-thickness-in-patients-with-diabetic-retinopathy
#12
Zaigen Ohara, Hitoshi Tabuchi, Shunsuke Nakakura, Yuki Yoshizumi, Hitomi Sumino, Yukiko Maeda, Yoshiaki Kiuchi
PURPOSE: To investigate the changes in choroidal thickness (ChT) following panretinal photocoagulation (PRP) for diabetic retinopathy (DR) and compare ChT in relation to DR severity. METHODS: Thirty-two eyes [19 eyes with proliferative DR (PDR) and 13 eyes with severe nonproliferative DR (NPDR)] for which PRP was necessary were analyzed. ChT was measured before PRP and at 1, 3, and 6 months after PRP using the swept-source optical coherence tomography. ChT of the 61 eyes matched with the PDR patients for the mean age and axial length was also measured and statistically compared in relation to severity...
February 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28137601/genome-wide-mrna-analysis-reveals-a-tubd1-isoform-profile-as-a-potential-biomarker-for-diabetic-retinopathy-development
#13
Vanessa Villegas-Ruiz, Ferdinand Hendlmeier, Beatriz Buentello-Volante, José L Rodríguez-Loaiza, Antonio Miranda-Duarte, Juan C Zenteno
Diabetic retinopathy (DR) affects approximately one third of all diabetic subjects and is the leading cause of blindness in young to middle-aged adults in the developed world. While early diagnosis is crucial for preventing DR-associated visual loss, the identification of accessible biomarkers that could lead to presymptomatic recognition of the disease is of great clinical importance. The aim of this work was to investigate the possible involvement of alternative splicing events in DR development by performing a genome-wide transcriptional profiling comparing blood-derived RNA from DR subjects and from diabetic-non DR controls...
January 27, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28118284/increased-serum-levels-of-urea-and-creatinine-are-surrogate-markers-for-disruption-of-retinal-photoreceptor-external-limiting-membrane-and-inner-segment-ellipsoid-zone-in-type-2-diabetes-mellitus
#14
Sandeep Saxena, Surabhi Ruia, Senthamizh Prasad, Astha Jain, Nibha Mishra, Shankar M Natu, Carsten H Meyer, Jagjit S Gilhotra, Peter Kruzliak, Levent Akduman
PURPOSE: To evaluate the role of serum urea and creatinine as surrogate markers for disruption of retinal photoreceptor external limiting membrane (ELM) and inner segment ellipsoid zone (EZ) in Type 2 diabetic retinopathy (DR) using spectral-domain optical coherence tomography, for the first time. METHODS: One hundred and seventeen consecutive cases of Type 2 diabetes mellitus (diabetes without retinopathy [No DR; n = 39], nonproliferative diabetic retinopathy [NPDR; n = 39], proliferative diabetic retinopathy [PDR; n = 39]) and 40 healthy control subjects were included...
February 2017: Retina
https://www.readbyqxmd.com/read/28099347/prediction-of-risk-of-diabetic-retinopathy-for-all-cause-mortality-stroke-and-heart-failure-evidence-from-epidemiological-observational-studies
#15
Xiao-Rong Zhu, Yong-Peng Zhang, Lu Bai, Xue-Lian Zhang, Jian-Bo Zhou, Jin-Kui Yang
To examine and quantify the potential relation between diabetic retinopathy (DR) and risk of all-cause mortality, stroke and heart failure (HF).The resources of meta-analysis of epidemiological observational studies were from Pub-med, EMBASE, CINAHL, Cochrane Library, conference, and proceedings.Random/fixed effects models were used to calculate pooled subgroup analysis stratified by different grades of DR was performed to explore the potential source of heterogeneity. Statistical manipulations were undertaken using program STATA...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28098726/assessment-of-retinal-blood-flow-in-diabetic-retinopathy-using-doppler-fourier-domain-optical-coherence-tomography
#16
Sowmya Srinivas, Ou Tan, Muneeswar G Nittala, Jennifer L Wu, Amani A Fazwi, David Huang, SriniVas R Sadda
PURPOSE: To evaluate retinal blood flow measurements in normal eyes and eyes with varying levels of diabetic retinopathy (DR) using Doppler Fourier-domain optical coherence tomography (FD-OCT). METHODS: Twenty-two eyes of 19 subjects, 10 with severe nonproliferative DR (NPDR) and 12 with proliferative DR (PDR), were compared with 44 eyes of 40 healthy control subjects. All eyes were scanned by RTvue FD-OCT. Color disk photographs and cube/volume scans of the optic nerve head were obtained...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28079928/relation-of-serum-and-vitreous-nesfatin-1-concentrations-with-diabetic-retinopathy
#17
Rongfeng Dai, Guohua Deng, Zhuo Sun, Zhinan Liu, Yu Qian, Yan Han
OBJECTIVE: Nesfatin-1, belonging to adipokine family, serves as an anti-inflammatory mediator. We performed this investigation to evaluate the relation between serum and vitreous nesfatin-1 concentrations with diabetic retinopathy (DR). METHODS: This study was performed in a population of 189 diabetic patients and 48 control subjects. Diabetic patients were then divided into diabetic patients without DR, non-proliferative diabetic retinopathy (NPDR) patients, and proliferative diabetic retinopathy (PDR) patients...
January 12, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28005667/an-automatic-intercapillary-area-based-algorithm-for-quantifying-diabetes-related-capillary-dropout-using-optical-coherence-tomography-angiography
#18
Julia Schottenhamml, Eric M Moult, Stefan Ploner, ByungKun Lee, Eduardo A Novais, Emily Cole, Sabin Dang, Chen D Lu, Lennart Husvogt, Nadia K Waheed, Jay S Duker, Joachim Hornegger, James G Fujimoto
PURPOSE: To develop a robust, sensitive, and fully automatic algorithm to quantify diabetes-related capillary dropout using optical coherence tomography (OCT) angiography (OCTA). METHODS: A 1,050-nm wavelength, 400 kHz A-scan rate swept-source optical coherence tomography prototype was used to perform volumetric optical coherence tomography angiography imaging over 3 mm × 3 mm fields in normal controls (n = 5), patients with diabetes without diabetic retinopathy (DR) (n = 7), patients with nonproliferative diabetic retinopathy (NPDR) (n = 9), and patients with proliferative diabetic retinopathy (PDR) (n = 5); for each patient, one eye was imaged...
December 2016: Retina
https://www.readbyqxmd.com/read/27916496/hyperlipidemia-mediated-increased-advanced-lipoxidation-end-products-formation-an-important-factor-associated-with-decreased-erythrocyte-glucose-6-phosphate-dehydrogenase-activity-in-mild-nonproliferative-diabetic-retinopathy
#19
Subhadip Choudhuri, Pijush Kanti Roy, Bhaskar Mitra, Susruta Sen, Rajarshi Sarkar, Mandrita Das, Debashree Biswas, Prithwijit Ghosh, Ajoy Biswas, Shaibal Chakraborty, Lakshmi Kanta Mondal
OBJECTIVES: The present study aimed to evaluate the role of hyperlipidemia in increased formation of advanced lipoxidation end products (ALEs) and to evaluate whether there is any relationship between ALEs generation and erythrocyte glucose-6-phosphate dehydrogenase (G6PD) activity in cases of mild nonproliferative diabetic retinopathy (MNPDR). METHODS: In this study, we enrolled 100 patients with type 2 diabetes and MNPDR, 100 subjects with type 2 diabetes but without retinopathy (DNR) and 90 normal individuals without diabetes as healthy controls (HCs)...
February 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27887743/quantification-of-diabetic-macular-ischemia-using-optical-coherence-tomography-angiography-and-its-relationship-with-visual%C3%A2-acuity
#20
Wasim A Samara, Abtin Shahlaee, Murtaza K Adam, M Ali Khan, Allen Chiang, Joseph I Maguire, Jason Hsu, Allen C Ho
PURPOSE: To quantify foveal avascular zone (FAZ) area and macular vascular density objectively using optical coherence tomography angiography (OCTA) and to examine correlations with visual acuity in eyes with diabetic retinopathy (DR) in the absence of diabetic macular edema. DESIGN: Retrospective observational case series. PARTICIPANTS: Eighty-four eyes from 55 patients with DR and 34 control eyes from 27 age-matched healthy participants...
February 2017: Ophthalmology
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