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Minhaj Alam, Taeyoon Son, Devrim Toslak, Jennifer I Lim, Xincheng Yao
Purpose: This study aims to develop a fully automated algorithm for artery-vein (A-V) and arteriole-venule classification and to quantify the effect of hypertension on A-V caliber and tortuosity ratios of nonproliferative diabetic retinopathy (NPDR) patients. Methods: We combine an optical density ratio (ODR) analysis and blood vessel tracking (BVT) algorithm to classify arteries and veins and arterioles and venules. An enhanced blood vessel map and ODR analysis are used to determine the blood vessel source nodes...
April 2018: Translational Vision Science & Technology
Qi Chen, Fan Tan, Yufei Wu, Xiran Zhuang, Chaoming Wu, Yuheng Zhou, Yingzi Li, Dan Cheng, Jianhua Wang, Fan Lu, Meixiao Shen
Purpose: To investigate early retinal structural and microvascular changes in patients with type 2 diabetes mellitus (DM) and to analyze relationships among the retinal structure, microvasculature, and choroid. Methods: Seventy-seven patients with type 2 DM (40 with no diabetic retinopathy [DR], 37 with nonproliferative diabetic retinopathy [NPDR]), and 34 control subjects were enrolled. Spectral-domain optical coherence tomography, operating in radial 18-line mode, obtained macular images of the eight intraretinal layers and the choroid...
April 1, 2018: Investigative Ophthalmology & Visual Science
Jianqin Lei, Enhui Yi, Yan Suo, Cheng Chen, Xiayu Xu, Wenxiang Ding, Nizar Saleh Abdelfattah, Xiaojuan Fan, Huiqin Lu
Purpose: To quantify and evaluate macular superficial capillaries and large vessels separately using an optical coherence tomographic angiography (OCTA)-based automatic segmentation algorithm. Methods: In this cross-sectional study, all eyes were scanned using an OCTA device with 3 × 3 mm cube centered on the fovea. Retinal large vessels (arterioles/venules) were automatically segmented from superficial vasculature en-face images. All images were normalized, binarized, and skeletonized for quantification...
April 1, 2018: Investigative Ophthalmology & Visual Science
Rui Shi, Lei Zhao, Yun Qi
BACKGROUND: Previous studies suggested that use of fenofibrate could significantly reduce the rate of progression into diabetic retinopathy (DR), and that retinal nerve fiber layer (RNFL) loss, which has been considered an important indicator for retinal neurodegeneration, might precede microvascular changes. The aim of this study was to assess the effect(s) of fenofibrate on RNFL thickness at early stage of DR in patients with type 2 diabetes mellitus (DM). METHODS: In this retrospective matched case-control study we included a cohort of 89 patients with type 2 DM, aged 40 or above, between Jan 1, 2017 and March 31, 2017...
April 18, 2018: BMC Ophthalmology
Nivedhitha Govindaswamy, Santosh G Gadde, Lavanya Chidambara, Devanshi Bhanushali, Neha Anegondi, Abhijit Sinha Roy
Projection artifacts (PA) affect the quantification of vascular parameters in the deep layer OCT angiography image. This study eliminated PA and quantified its effect on imaging. 53 eyes (30 subjects) of normal Indian subjects and 113 eyes (92 patients) of type 2 diabetes mellitus with retinopathy (DR) underwent imaging with a scan area of 3 mm × 3 mm. In this study, a normalized cross-correlation between superficial and deep layer was used to remove PA in deep layer. Local fractal analysis was done to compute vascular parameters such as foveal avascular zone area (mm2 ), vessel density (%), spacing between large vessels (%) and spacing between small vessels (%)...
April 16, 2018: Journal of Biophotonics
Ayse Gul Kocak Altintas, Bayram Gulpamuk, Veysel Cankurtaran, Cagri Ilhan, Mehmet Citirik
This study aimed at evaluating the correlation between changes in Hemoglobin A1c (HbA1c) and fasting serum lipids, and Central Macular Thickness (CMT) in patients with Non-Proliferative Diabetic Retinopathy (NPDR). In the current research, both eyes of 68 patients with mild or moderate NPDR, without clinically significant macular edema, were studied. Levels of fasting serum lipids, HbAlc, and CMT were measured during the first visit and at the end of the follow-up period (3 months). For statistical analysis, CMTs of each eye were studied and the correlation of changes was investigated...
2018: Medical Hypothesis, Discovery and Innovation in Ophthalmology
Ling Chen, Xiongze Zhang, Feng Wen
PURPOSE: To determine whether venous beading (VB) in two or more quadrants is an appropriate grading criterion for severe nonproliferative diabetic retinopathy (NPDR). METHODS: A hospital-based, retrospective, cross-sectional study. A total of 806 patients admitted with diabetic retinopathy (DR) from January 2014 to April 2017 were included in this study. DR severity was graded by the international grading criterion. The status of VB, intraretinal microvascular abnormalities (IRMA), capillary nonperfusion, arteriovenous nicking, and diabetic macular edema was evaluated based on fundus fluorescein angiography...
April 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Cai-Guo Yu, Sha-Sha Yuan, Long-Yan Yang, Jing Ke, Li-Jie Zhang, Jia-Nan Lang, Da-Wei Zhang, Shao-Zhen Zhao, Dong Zhao, Ying-Mei Feng
PURPOSE: To investigate whether angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) are differentially associated with the severity of retinopathy in patients with type 2 diabetes mellitus (T2DM). DESIGN: Cross-sectional study. METHODS: Serum levels of ANGPTL3, ANGPTL4, high-sensitivity C-reactive protein (CRP), vascular adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1) and vascular endothelial growth factor (VEGF) were quantified by ELISA...
April 2, 2018: American Journal of Ophthalmology
Mukesh Jain, Sandeep Devan, Durgasri Jaisankar, Gayathri Swaminathan, Shahina Pardhan, Rajiv Raman
Our aim is to study the dynamics of pupillary abnormalities in varying severity of diabetic retinopathy. A non-interventional case-control study with 405 eyes of 244 subjects with diabetes, and 41 eyes of 26 subjects with no history of diabetes was done. Diabetes group was classified according to retinopathy severity: no retinopathy, mild non-proliferative diabetic retinopathy (NPDR), moderate NPDR, severe NPDR and proliferative diabetic retinopathy (PDR). After dark adaptation, pupil size and flashlight response were captured with an infrared camera...
April 4, 2018: Scientific Reports
Tarjani Makwana, Brijesh Takkar, Pradeep Venkatesh, Jai Bhagwan Sharma, Yashdeep Gupta, Rohan Chawla, Rajpal Vohra, Alka Kriplani, Nikhil Tandon
Purpose: The objective of this study is to evaluate pattern of diabetic retinopathy (DR) during pregnancy in females with pregestational diabetes mellitus (DM). Methods: This is an ambispective observational cohort study conducted at an Indian tertiary care centre. A total of 50 pregnant females with pregestational DM were included while those with gestational DM were excluded from the study. Ocular examination (inclusive of fundus photography) was conducted and systemic parameters (inclusive of Glycated hemoglobin) were assessed during each of the 3 trimesters and 3 months postpartum...
April 2018: Indian Journal of Ophthalmology
Conceição Lobo, Isabel Pires, Dalila Alves, Rajeev Pappuru, Luísa Ribeiro, José Cunha-Vaz
PURPOSE: The aim of this study was to examine the relationship between subclinical diabetic macular edema (SCME) and the development of central-involved macular edema (CIME) in patients with diabetes mellitus type-2 and mild nonproliferative diabetic retinopathy (NPDR), from 2 populations of different ethnicities. METHODS: Two hundred and five patients with diabetes mellitus type-2 and mild NPDR with no prior laser or intravitreal treatment were followed for 2 years or until the development of CIME...
March 6, 2018: Ophthalmic Research
Berthold Pemp, Stefan Palkovits, Kinga Howorka, Jiri Pumprla, Stefan Sacu, Gerhard Garhöfer, Michaela Bayerle-Eder, Leopold Schmetterer, Ursula Schmidt-Erfurth
PURPOSE: To evaluate the relationship of neuroretinal layer thickness with sensitive measures of cardiovascular autonomic neuropathy in diabetic patients with non-proliferative diabetic retinopathy (NPDR). METHODS: Twenty-seven eyes of 27 patients with type 1 diabetes presenting with mild-to-moderate NPDR were compared to 27 healthy control (HC) eyes matched for age and gender. The total macular volume (TMV) and the volumes of individual neurosensory layers in the macula were analysed from spectral domain optical coherence tomography using automated layer segmentation...
March 5, 2018: Acta Ophthalmologica
Matias Iglicki, Dinah Zur, Catharina Busch, Mali Okada, Anat Loewenstein
PURPOSE: Intravitreal anti-vascular endothelial growth factor agents have been shown to reduce diabetic retinopathy (DR) progression; data on the effects of intravitreal corticosteroids on modifying disease severity are limited. This study evaluates the long-term effect of intravitreal dexamethasone implant (DEX) on the severity and progression of non-proliferative DR (NPDR). METHODS: This was a retrospective cohort study. Sixty eyes from 60 consecutive patients with NPDR and diabetic macular edema (DME) treated with dexamethasone implant (DEX group) and 49 eyes from consecutive 49 patients without DME requiring observation only...
March 1, 2018: Acta Diabetologica
Qamar Ul Islam, Mohammad Asim Mehboob, Zulfiqar Ali Amin
Objective: To compare corneal morphological parameters between diabetics and age matched non-diabetic control subjects and to evaluate the correlation of these parameters in relation to duration of diabetes mellitus (DM), glycemic status and severity of diabetic retinopathy.(DR). Methods: This cross sectional comparative study was conducted at the Department of Ophthalmology, PNS Shifa Karachi from February 2016 to January 2017. Patients with ages between 10 to 80 years of either gender who were diagnosed to have DM were recruited in the study...
November 2017: Pakistan Journal of Medical Sciences Quarterly
Xiao Zhang, Wai Kitt Chee, Sylvia Liu, Subramaniam Tavintharan, Chee Fang Sum, Su Chi Lim, Neelam Kumari
Purpose: Osteopontin (OPN) is a proinflammatory cytokine with diverse functions. Increased levels of OPN in vitreous fluid have been reported in patients with diabetic retinopathy (DR); however, studies on circulating OPN levels in DR are limited. We aim to examine the association of plasma OPN levels with the presence and severity of DR in a multiethnic cohort with type 2 diabetes mellitus (type 2 diabetes) in Singapore. Methods: Plasma levels of OPN were measured using enzyme-linked immunosorbent assay...
2018: Molecular Vision
Meenakshi Wadhwani, Praveen Vashist, Suraj Senjam Singh, Noopur Gupta, Pallavi Shukla, Amit Bhardwaj, Vivek Gupta
OBJECTIVES: To develop and implement a community-based program for screening of diabetic retinopathy (DR) in urban populations of Delhi. METHODS: Known diabetics (KDs) aged 40 years and older were identified through house-to-house surveys, volunteers and publicity. All KDs were referred to DR screening camps organised locally where procedures included brief medical history, ocular examination, and non-mydriatic fundus photography using portable handheld camera. Fundal images were graded on the spot by trained optometrists for diabetic retinopathy (DR)...
February 12, 2018: Tropical Medicine & International Health: TM & IH
Y Zhang, M Niu, Y Li, J Wang, B Qu, C X Zheng, P Huang, W H Yu
Objective: To analyze the prevalence and risk factors of diabetic retinopathy (DR) in ophthalmic patients. Methods: A cross-sectional study was performed. Diabetic patients who were admitted to Department of Ophthalmology, Traditional Chinese Medicine Hospital of Muping between October 2012 and June 2013 were included. General information and medical history were obtained from each subject by questionaires. Laboratory and detailed ophthalmic examinations were performed during the study. DR was diagnosed and graded by mydriatic fundus photography...
February 6, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Liyuan Peng, Bei Sun, Mingming Liu, Jing Huang, Yajin Liu, Zipeng Xie, Jinlong He, Liming Chen, Daowen Wang, Yi Zhu, Xu Zhang, Ding Ai
Diabetic retinopathy (DR) is the most frequent microvascular complications of diabetes and the leading cause of blindness in adults worldwide. Non-proliferative DR (NPDR) is the first stage of DR but currently has few recommended intervention. Eicosanoids play important roles in maintaining vessel homeostasis. However, the functions of eicosanoids in NPDR are still unknown. In this study, we investigated the eicosanoids profile difference in plasma between type 2 diabetes with NPDR or not. A total of 50 patients with type 2 diabetes were recruited and divided into non-DR (NDR) group and NPDR group based on fundus photographs...
February 1, 2018: Biochemical and Biophysical Research Communications
M D Pinazo-Durán, K Shoaie-Nia, S M Sanz-González, J Raga-Cervera, J J García-Medina, M I López-Gálvez, D Galarreta-Mira, L Duarte, C Campos-Borges, V Zanón-Moreno
OBJECTIVE: To identify genes involved in the pathogenic mechanisms of non-proliferative diabetic retinopathy (NPDR), among which include oxidative stress, extracellular matrix changes, and/or apoptosis, in order to evaluate the risk of developing this retinal disease in a type2 diabetic (DM2) population. MATERIAL AND METHODS: A case-control study was carried out on 81 participants from the Valencia Study on Diabetic Retinopathy (VSDR) of both genders, with ages 25-85years...
February 1, 2018: Archivos de la Sociedad Española de Oftalmología
Mahima Jhingan, Abhilash Goud, Hari Kumar Peguda, Mitali Khodani, Jeffrey K Luttrull, Jay Chhablani
Aim: To compare the outcomes of subthreshold microsecond (STM) and continuous-wave laser (CWL) panretinal photocoagulation (PRP). Methods: In this randomized, prospective, pilot study, 20 eyes of 10 subjects with symmetric severe non-proliferative (NPDR) or low-risk proliferative diabetic retinopathy (PDR) were included. Each eye of the subject was randomized into either CWL or STM PRP group. Patients were evaluated at baseline and at months 3, 6, and 9 with color fundus photographs and visual field tests at each visit; however, electroretinography (ERG) was conducted at baseline and at month 9...
2018: Clinical Ophthalmology
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