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https://www.readbyqxmd.com/read/29207695/association-of-glycated-haemoglobin-and-serum-apolipoproteins-with-diabetic-retinopathy-an-indian-overview
#1
Bhasker Mukherjee, Sandeep Shankar, Rehan Ahmed, Kanchan Singh, Kapil Bhatia
Introduction: India is presently facing an epidemic of diabetes mellitus and the risks of chronic complications from the disease are associated with the duration of the disease as well as the degree of hyperglycaemia. Diabetic retinopathy is a known microvascular complication of diabetes mellitus and is the most common cause of blindness in the western countries.Apolipoproteins are the protein component of lipoproteins. Apart from acting as structural proteins, they also act as cofactors to various enzymes...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29177923/skin-autofluorescence-is-a-noninvasive-surrogate-marker-for-diabetic-microvascular-complications-and-carotid-intima-media-thickness-in-japanese-patients-with-type-2-diabetes-a-cross-sectional-study
#2
Keiji Yoshioka
INTRODUCTION: Advanced glycation end-products (AGEs) are known to play an important role in the pathogenesis of diabetic complications. Skin autofluorescence (AF), a marker of AGE accumulation in tissue, can be measured noninvasively using a skin AF reader. The present study aimed to evaluate the relationships of skin AF with diabetic microvascular complications and carotid intima-media thickness (IMT), a surrogate marker for atherosclerosis, in Japanese subjects with type 2 diabetes (T2D)...
November 24, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29168314/elevated-plasma-and-vitreous-levels-of-leucine-rich-%C3%AE-2-glycoprotein-are-associated-with-diabetic-retinopathy-progression
#3
Chong Chen, Xia Chen, Hengye Huang, Changjing Han, Yuan Qu, Huiyi Jin, Tian Niu, Yuan Zhang, Kun Liu, Xun Xu
PURPOSE: To investigate the association of plasma and vitreous leucine-rich-α2-glycoprotein (LRG1) with diabetic retinopathy (DR) progression. METHODS: A total of 86 outpatients and 33 inpatients were recruited. Outpatients with type 2 diabetes mellitus (T2DM) were classified as T2DM without DR (n = 22), nonproliferative DR (NPDR) (n = 20) and proliferative DR (PDR) (n = 22) based on international clinical DR severity scales. A total of 86 plasma and 33 vitreous samples were collected and subjected to enzyme-linked immunosorbent assay...
November 23, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29133026/levels-of-adhesion-molecules-in-peripheral-blood-correlat-with-stages-of-diabetic-retinopathy-and-may-serve-as-bio-markers-for-microvascular-complications
#4
Arnon Blum, Nina Pastukh, Dorina Socea, Hanin Jabaly
BACKGROUND: Proliferative diabetic retinopathy is a devastating complication of diabetes mellitus, developing within 15 years in 50% of patients with type 1 diabetes mellitus (DM) and in 10% of patients with type 2 DM. The correlation between levels of inflammatory markers in the peripheral blood and retinopathy staging has not been studied yet, and the purpose of this prospective study was to find a possible association between inflammation and staging of diabetic retinopathy. METHODS: A prospective (pilot) study that measured level of adhesion molecules in the peripheral blood of 10 healthy subjects and 30 patients with type 2 diabetes mellitus...
November 10, 2017: Cytokine
https://www.readbyqxmd.com/read/29099033/vegf-b-levels-in-the-vitreous-of-diabetic-and-non-diabetic-patients-with-ocular-diseases-and-its-correlation-with-structural-parameters
#5
Joana Mesquita, João Paulo Castro de Sousa, Sara Vaz-Pereira, Arminda Neves, Paulo Tavares-Ratado, Fátima M Santos, Luís A Passarinha, Cândida T Tomaz
Vascular endothelial growth factor B (VEGF-B) is one of the enigmatic members of the VEGF family. The knowledge gap about VEGF-B expression and how its levels are altered in diabetic eyes were the focus of this investigation that was addressed by comparing and correlating vitreous VEGF-B between diabetic and non-diabetic patients. VEGF-B levels were measured by enzyme-linked immunosorbent assay in vitreous samples (n = 33) from diabetic (n = 25) and non-diabetic (n = 8) patients. Results were compared between groups...
August 9, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29090846/the-relation-study-efficacy-and-safety-of-ranibizumab-combined-with-laser-photocoagulation-treatment-versus-laser-monotherapy-in-npdr-and-pdr-patients-with-diabetic-macular-oedema
#6
Gabriele E Lang, Sandra Liakopoulos, Jessica Vögeler, Claudia Weiß, Georg Spital, Maria-Andreea Gamulescu, Chris Lohmann, Peter Wiedemann
PURPOSE: To assess efficacy and safety of intravitreal ranibizumab 0.5 mg plus laser (COMBI) versus laser monotherapy (LASER) in patients with visual impairment due to diabetic macular oedema (DME) in either nonproliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) and to analyse the relevance of inner versus outer retinal thickness. METHODS: In this double-masked, multicentre phase IIIb study, patients (N = 128) were randomized (2:1) to receive COMBI (n = 85) versus LASER (n = 43)...
November 1, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29090043/distribution-of-different-sized-ocular-surface-vessels-in-diabetics-and-normal-individuals
#7
Touka Banaee, Hamidreza Pourreza, Hassan Doosti, Mojtaba Abrishami, Asieh Ehsaei, Mohsen Basiry, Reza Pourreza
PURPOSE: To compare the distribution of different sized vessels using digital photographs of the ocular surface of diabetic and normal individuals. METHODS: In this cross-sectional study, red-free conjunctival photographs of diabetic and normal individuals, aged 30-60 years, were taken under defined conditions and analyzed using a Radon transform-based algorithm for vascular segmentation. The image areas occupied by vessels (AOV) of different diameters were calculated...
October 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29089151/total-serum-cholesterol-increases-risk-for-development-and-progression-of-nonproliferative-retinopathy-in-patients-with-type-1-diabetes-without-therapeutic-intervention-prospective-observational-study
#8
Tomislav Bulum, Martina Tomić, Lea Duvnjak
INTRODUCTION: Results from studies investigating relationship between serum lipids and risk of development and progression of diabetic retinopathy (DR) in patients with type 1 diabetes (T1DM) are not consistent. The objective of this study was to explore the relationship between serum lipids and risk of development and progression of nonproliferative diabetic retinopathy (NPDR) in T1DM with normal renal function and with no therapeutic intervention that might influence on retinopathy and serum lipids status...
October 28, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29084332/assessment-of-neurotrophins-and-inflammatory-mediators-in-vitreous-of-patients-with-diabetic-retinopathy
#9
Joseph D Boss, Pawan Kumar Singh, Hemang K Pandya, Joaquin Tosi, Chaesik Kim, Asheesh Tewari, Mark S Juzych, Gary W Abrams, Ashok Kumar
Purpose: To assess vitreous levels of inflammatory cytokines and neurotrophins (NTs) in diabetic retinopathy (DR) and elucidate their potential roles. Methods: A prospective study was performed on 50 vitreous samples obtained from patients with DR (n = 22) and the nondiabetic controls (n = 28). All patients were candidates for vitrectomy. Inflammatory cytokine and NT levels were determined with ELISA. Potential source and role of NTs was determined by using human retinal Müller glia and mouse photoreceptor cells and challenging them with TNF-α or IL-1β, followed by detection of NTs and cell death...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29079858/retinal-oximetry-and-vessel-diameter-measurements-with-a-commercially-available-scanning-laser-ophthalmoscope-in-diabetic-retinopathy
#10
Norman P Blair, Justin Wanek, Anthony E Felder, Charlotte E Joslin, Jacob K Kresovich, Jennifer I Lim, Felix Y Chau, Yannek Leiderman, Mahnaz Shahidi
Purpose: To test the hypothesis that retinal vascular diameter and hemoglobin oxygen saturation alterations, according to stages of diabetic retinopathy (DR), are discernible with a commercially available scanning laser ophthalmoscope (SLO). Methods: One hundred eighty-one subjects with no diabetes (No DM), diabetes with no DR (No DR), nonproliferative DR (NPDR), or proliferative DR (PDR, all had photocoagulation) underwent imaging with an SLO with dual lasers (532 nm and 633 nm)...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29023169/associations-of-physical-activity-and-sedentary-behaviour-with-vision-threatening-diabetic-retinopathy-in-indonesian-population-with-type-2-diabetes-mellitus-jogjakarta-eye-diabetic-study-in-the-community-joged-com
#11
D P Dharmastuti, A N Agni, F Widyaputri, S Pawiroranu, Z M Sofro, F S Wardhana, S Haryanto, T W Widayanti, S Kotha, P Gupta, M B Sasongko
PURPOSE: To investigate the association of physical activity (PA) and sedentary behaviour with diabetic retinopathy (DR) in type 2 diabetes adults. METHODS: A community-based cross-sectional study of adults with type 2 diabetes. DR was assessed from disc- and macula-centred fundus photograph, and categorised into mild, moderate non-proliferative DR (NPDR), and Vision-Threatening DR (VTDR). Worse eye was used to determine the person's DR severity. PA was assessed using WHO Global Physical Activity Questionnaire (GPAQ)...
October 12, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29022954/agreement-on-diabetic-retinopathy-grading-in-fundus-photographs-by-allied-ophthalmic-personnel-as-compared-to-ophthalmologist-at-a-community-setting-in-nepal
#12
Raba Thapa, Sanyam Bajimaya, Eli Pradhan, Govinda Paudyal
INTRODUCTION: Diabetic retinopathy (DR) is the emerging cause of blindness in the developing world. Timely detection of DR could save vision from its avoidable blinding condition. OBJECTIVE: To assess the accuracy of DR grading in fundus photographs by the allied ophthalmic personnel (AOP) as compared to ophthalmologist at a community setting in Nepal. MATERIALS AND METHODS: Fundus photographs of known diabetes subjects attending for DR screening were graded by two groups of AOP and ophthalmologist...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28988899/diabetic-choroidopathy-choroidal-vascular-density-and-volume-in-diabetic-retinopathy-with-swept-source-optical-coherence-tomography
#13
Jay C Wang, Inês Laíns, Joana Providência, Grayson W Armstrong, Ana R Santos, Pedro Gil, João Gil, Katherine E Talcott, João H Marques, João Figueira, Demetrios G Vavvas, Ivana K Kim, Joan W Miller, Deeba Husain, Rufino Silva, John B Miller
PURPOSE: To compare choroidal vascular density (CVD) and volume (CVV) in diabetic eyes and controls, using en face swept-source optical coherence tomography (SS-OCT). DESIGN: Prospective cross-sectional study. METHODS: ▪▪▪ SETTING: Multicenter PATIENT POPULATION: 143 diabetic eyes - 27 with no diabetic retinopathy (DR), 47 with nonproliferative DR (NPDR), 51 with NPDR and diabetic macular edema (DME), and 18 with proliferative DR (PDR), and 64 age-matched non-diabetic control eyes...
October 5, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28979738/role-of-angiopoietins-and-tie-2-in-diabetic-retinopathy
#14
Nervana Khalaf, Hazem Helmy, Hany Labib, Iman Fahmy, Mona Abd El Hamid, Leqaa Moemen
OBJECTIVE: The aim of this study was to determine the serum levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), soluble vascular endothelial tyrosine kinase receptor (Tie-2) and vascular endothelial growth factor (VEGF), in the serum of type 2 diabetic patients having non-proliferative (NPDR) or proliferative diabetic retinopathy (PDR). METHODS: One hundred patients with type 2 diabetes mellitus were involved in this cross-sectional study. They were classified into 25 diabetic patients without retinopathy, 35 patients with NPDR and 40 PDR patients...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28973335/optical-coherence-tomography-angiography-reveals-spatial-bias-of-macular-capillary-dropout-in-diabetic-retinopathy
#15
Yoshihiro Kaizu, Shintaro Nakao, Shigeo Yoshida, Takehito Hayami, Mitsuru Arima, Muneo Yamaguchi, Iori Wada, Toshio Hisatomi, Yasuhiro Ikeda, Tatsuro Ishibashi, Koh-Hei Sonoda
Purpose: Our purpose is to evaluate the spatial bias of macular capillary dropout accompanying diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). Methods: This study included 47 patients with diabetes and 29 healthy individuals who underwent OCTA. Retinal capillary flow density (FD) of 2.6 × 2.6 or 5.2 × 5.2 mm foveal area as well as the four divided areas (superior, inferior, temporal, nasal) without a foveal avascular zone (FAZ) at the superficial capillary plexus and deep capillary plexus (DCP) were measured respectively using ImageJ and NI Vision...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28973314/multidimensional-functional-and-structural-evaluation-reveals-neuroretinal-impairment-in-early-diabetic-retinopathy
#16
Katherine A Joltikov, Vinicius M de Castro, Jose R Davila, Rohit Anand, Sami M Khan, Neil Farbman, Gregory R Jackson, Chris A Johnson, Thomas W Gardner
Purpose: To test whether quantitative functional tests and optical coherence tomography (OCT)-defined structure can serve as effective tools to diagnose and monitor early diabetic neuroretinal disease. Methods: Fifty-seven subjects with diabetes (23 without diabetic retinopathy [no DR], 19 with mild nonproliferative diabetic retinopathy [mild NPDR], 15 with moderate to severe [moderate NPDR]), and 18 controls underwent full ophthalmic examination, fundus photography, spectral-domain optical coherence tomography (SD-OCT), e-ETDRS (Early Treatment Diabetic Retinopathy Study) acuity, and the quick contrast sensitivity function (qCSF) method...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28964682/association-of-functional-snp-1562c-t-in-mmp9-promoter-with-proliferative-diabetic-retinopathy-in-north-indian-type-2-diabetes-mellitus-patients
#17
Kanhaiya Singh, Prabhjot Goyal, Manju Singh, Sujit Deshmukh, Divyesh Upadhyay, Sri Kant, Neeraj K Agrawal, Sanjeev K Gupta, Kiran Singh
OBJECTIVE: Retinal angiogenesis is a hallmark of diabetic retinopathy. Matrix Metalloproteinases (MMPs) are involved in degradation of extracellular matrix (ECM). Functional SNP-1562C>T in the promoter of the MMP-9 gene results increase in transcriptional activity. The present work was designed to evaluate the contribution of functional SNP-1562C>T of MMP-9 gene to the risk of proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM) patients in north Indian Population...
August 26, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28937857/evaluation-of-retinal-blood-flow-before-and-after-panretinal-photocoagulation-using-pattern-scan-laser-for-diabetic-retinopathy
#18
Yoshihisa Yamada, Kiyoshi Suzuma, Naoko Onizuka, Masafumi Uematsu, Yasser Helmy Mohamed, Takashi Kitaoka
PURPOSE: Laser speckle flowgraphy (LSFG) can measure blood flow in the ocular fundus. We analyzed the relationship between retinal blood flow and panretinal photocoagulation (PRP) in diabetic retinopathy. METHODS: This retrospective observational study examined the eyes of 35 patients with proliferative diabetic retinopathy (PDR) or non-PDR (NPDR). PRP was performed using a pattern scan laser. Using LSFG, blood flow was evaluated as the mean blur rate (MBR) or the relative flow volume (RFV)...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28930746/early-assessment-of-the-risk-factors-for-diabetic-retinopathy-can-reduce-the-risk-of-peripheral-arterial-and-cardiovascular-diseases-in-type-2-diabetes
#19
Juan Tang, Tao Li, Pinhong Li, Yuefei Ma, Momo Liu, Qiaoyun Shan, Fengqi Guo, Ting Zhou, Qianping Wei
BACKGROUNDS: There is still a lack of consensus about how to assess the risk of peripheral arterial disease (PAD) and cardiovascular disease (CVD) in patients with diabetic retinopathy (DR). AIMS: We investigated the risk factors for DR and their association with PAD and CVD in patients with type 2 diabetes (T2D). METHODS: A total of 1,421 patients diagnosed with T2D participated in this study. DR stages were classified as non-DR, nonproliferative DR (NPDR), or proliferative DR (PDR)...
September 21, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28924157/normal-to-mildly-increased-albuminuria-predicts-the-risk-for-diabetic-retinopathy-in-patients-with-type-2-diabetes
#20
Min-Kyung Lee, Kyung-Do Han, Jae-Hyuk Lee, Seo-Young Sohn, Oak-Kee Hong, Jee-Sun Jeong, Mee-Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
Albuminuria is closely associated with diabetic retinopathy (DR), but the precise role of the albumin-to-creatinine ratio (ACR) in screening for DR remains to be determined. This study aimed to investigate an ACR threshold for predicting DR in patients with type 2 diabetes. A cross-sectional study was conducted on 1,102 type 2 diabetes patients, aged ≥30 years and recruited from the Korea National Health and Nutrition Examination Survey, 2010-2011. Participants were grouped by stage of DR: mild-to-moderate nonproliferative DR (NPDR), severe NPDR, and proliferative diabetic retinopathy (PDR)...
September 18, 2017: Scientific Reports
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