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https://www.readbyqxmd.com/read/27887743/quantification-of-diabetic-macular-ischemia-using-optical-coherence-tomography-angiography-and-its-relationship-with-visual%C3%A2-acuity
#1
Wasim A Samara, Abtin Shahlaee, Murtaza K Adam, M Ali Khan, Allen Chiang, Joseph I Maguire, Jason Hsu, Allen C Ho
PURPOSE: To quantify foveal avascular zone (FAZ) area and macular vascular density objectively using optical coherence tomography angiography (OCTA) and to examine correlations with visual acuity in eyes with diabetic retinopathy (DR) in the absence of diabetic macular edema. DESIGN: Retrospective observational case series. PARTICIPANTS: Eighty-four eyes from 55 patients with DR and 34 control eyes from 27 age-matched healthy participants...
November 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27852582/association-between-oct-based-microangiography-perfusion-indices-and-diabetic-retinopathy-severity
#2
Alexander D Lin, Aaron Y Lee, Qinqin Zhang, Kasra A Rezaei, James Kinyoun, Ruikang K Wang, Cecilia S Lee
AIM: To evaluate the association between retinal capillary non-perfusion and diabetic retinopathy (DR) severity using optical coherence tomography-based microangiography (OMAG). METHODS: 33 patients (51 eyes) with a history of diabetes underwent imaging with a 68 kHz Cirrus-5000 spectral domain OMAG prototype. Demographic and clinical characteristics were collected. The perfusion index (PI) was defined as per cent coverage of area by retinal vessels with flow, measured within a minimum of 6...
November 15, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27846040/evaluation-of-apparent-diffusion-coefficient-measurements-of-brain-injury-in-type-2-diabetics-with-retinopathy-by-diffusion-weighted-mri-at-3-0%C3%A2-t
#3
Zhongling Wang, Ziwei Lu, Jing Li, Changjie Pan, Zhongzhi Jia, Hanqi Chen, Xiaomin Ge
Diabetes is often associated with impairments in brain functioning. However, the injury of specific functioning areas of the brain is not clear. To address this problem, the present study was designed to investigate possible brain functioning change in specific brain areas, particularly in areas associated with vision function, in patients with proliferative and nonproliferative diabetic retinopathy (PDR and NPDR) using the diffusion-weighted imaging technology. Conventional MRI was performed in 45 diabetic patients, 30 of whom had diabetic retinopathy (DR) involvement (half PDR, and half NPDR) and 15 of whom were diabetic patients without retinopathy and with normal ophthalmologic examination...
November 11, 2016: Neuroreport
https://www.readbyqxmd.com/read/27843643/changing-clinical-presentation-current-knowledge-attitude-practice-and-current-vision-related-quality-of-life-in-self-reported-type-2-diabetes-patients-with-retinopathy-in-eastern-india-the-lvpei-eye-and-diabetes-study
#4
Taraprasad Das, Batriti Wallang, Preeti Semwal, Soumyava Basu, Tapas R Padhi, Mohd Hasnat Ali
Purpose. To document the changing clinical presentation of diabetic retinopathy (DR) over a decade, the current knowledge-attitude-practice (KAP) of known type 2 diabetes mellitus (DM) patients, and the current vision related quality of life (VR-QOL) of patients with DR in a tertiary eye care center in Eastern India. Methods. Two hundred and forty patients with known type-2 DM were evaluated. The evaluation included status of DR (n = 240), KAP (n = 232), and VR-QOL (n = 75). International classification of DR was used in the study...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27830398/relationships-between-vitreous-levels-of-soluble-receptor-for-advanced-glycation-end-products-srage-and-renal-function-in-patients-with-diabetic-retinopathy
#5
Makiko Katagiri, Jun Shoji, Satoshi Kato, Shigehiko Kitano, Yasuko Uchigata
PURPOSE: We investigated the relationship between vitreous levels of soluble receptor for advanced glycation end products (sRAGE) and vascular endothelial growth factor (VEGF) and renal function, and correlations between vitreous sRAGE levels and proliferative diabetic retinopathy (PDR) activity. METHODS: We examined 33 eyes from 33 patients with diabetes mellitus who underwent a vitrectomy (eight patients in the non-PDR [NPDR] group and 25 in the PDR group). Serum creatinine levels and estimated glomerular filtration rate (eGFR) were measured and classified according to the chronic kidney disease (CKD)-staging method...
November 9, 2016: International Ophthalmology
https://www.readbyqxmd.com/read/27812207/white-dots-as-a-novel-marker-of-diabetic-retinopathy-severity-in-ultrawide-field-imaging
#6
Yoko Dodo, Tomoaki Murakami, Noriyuki Unoki, Ken Ogino, Akihito Uji, Shin Yoshitake, Nagahisa Yoshimura
PURPOSE: To characterize white dots in diabetic retinopathy (DR) and their association with disease severity using ultra-wide-field scanning laser ophthalmoscopy. METHODS: We randomly selected 125 eyes of 77 patients (25 eyes from individual categories of the international classification of DR severity) for which ultrawide field photographs were obtained. We characterized white dots, which were delineated by higher signal levels on green but not red laser images, and evaluated the relationship between the number of white dots and the international severity scale of DR...
2016: PloS One
https://www.readbyqxmd.com/read/27803861/effect-of-focal-laser-photocoagulation-in-eyes-with-mild-to-moderate-non-proliferative-diabetic-retinopathy
#7
Seong Hun Jeong, Jung Il Han, Sung Won Cho, Dong Won Lee, Chul Gu Kim, Tae Gon Lee, Jong Woo Kim
AIM: To report the effect of focal laser photocoagulation on both the severity of hard exudates (HEs) and the rate of disease progression in eyes with mild to moderate non-proliferative diabetic retinopathy (NPDR). METHODS: We retrospectively reviewed the medical records of 33 patients (60 eyes) who had been diagnosed with mild to moderate NPDR between January 2006 and December 2012. The patients were divided into 2 groups: Group A (38 eyes in 20 patients treated using focal laser photocoagulation) and Group B (treated without laser photocoagulation)...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27791250/retinal-neurovascular-changes-appear-earlier-in-type-2-diabetic-patients
#8
Luisa Pierro, Lorenzo Iuliano, Maria Vittoria Cicinelli, Giuseppe Casalino, Francesco Bandello
PURPOSE: To investigate the early neurodegenerative changes of inner retina and choroid in type 1 and type 2 diabetic patients without retinopathy and with early-stage retinopathy. METHODS: In this observational cross-sectional study, 90 right eyes of 90 naive type 1 and 2 diabetic patients without diabetic retinopathy (DR) and with mild to moderate nonproliferative DR (NPDR) were analyzed. Forty healthy eyes were included as controls. We used spectral-domain optical coherence tomography to evaluate the ganglion cell complex (GCC) thickness, the retinal nerve fiber layer (RNFL) thickness, the choroid thickness, and the central foveal thickness (CFT) of patients and controls...
October 22, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27768785/the-effects-of-diabetic-retinopathy-stage-and-light-flicker-on-inner-retinal-oxygen-extraction-fraction
#9
Anthony E Felder, Justin Wanek, Norman P Blair, Charlotte E Joslin, Katherine C Brewer, Felix Y Chau, Jennifer I Lim, Yannek I Leiderman, Mahnaz Shahidi
Purpose: We determined the effects of light flicker and diabetic retinopathy (DR) stage on retinal vascular diameter (D), oxygen saturation (SO2), and inner retinal oxygen extraction fraction (OEF). Methods: Subjects were categorized as nondiabetic control (NC, n = 42), diabetic with no clinical DR (NDR; n = 32), nonproliferative DR (NPDR; n = 42), or proliferative DR (PDR; n = 14). Our customized optical imaging system simultaneously measured arterial and venous D (DA, DV) and SO2 (SO2A, SO2V) before and during light flicker...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27766793/clinical-course-and-risk-factors-of-diabetic-retinopathy-in-patients-with-type-2-diabetes-mellitus-in-korea
#10
Jae Seung Yun, Tae Seok Lim, Seon Ah Cha, Yu Bae Ahn, Ki Ho Song, Jin A Choi, Jinwoo Kwon, Donghyun Jee, Yang Kyung Cho, Yong Moon Park, Seung Hyun Ko
BACKGROUND: We investigated clinical course and risk factors for diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 759 patients with T2DM without DR were included from January 2001 to December 2004. Retinopathy evaluation was performed at least annually by ophthalmologists. The severity of the DR was classified into five categories according to the International Clinical Diabetic Retinopathy Severity Scales. RESULTS: Of the 759 patients, 523 patients (68...
October 5, 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27729754/anterior-diabetic-retinopathy-studied-by-ultra-widefield-angiography
#11
Kunho Bae, Ju Yeon Lee, Tae Hyup Kim, Ga Eun Cho, Jeeyun Ahn, Sang Jin Kim, Jae Hyun Kim, Se Woong Kang
PURPOSE: To evaluate the prevalence of anterior type diabetic retinopathy (DR) using ultra-widefield fluorescein angiography and to identify the factors associated with anterior type DR incidence. METHODS: A retrospective case review was used in this study. Patients with non-proliferative diabetic retinopathy (NPDR) underwent examination by ultra-widefield fluorescein angiography, and were classified into anterior, posterior, or diffuse DR groups. Anterior DR was defined if diabetic retinal changes were noted only at the location anterior to the imaginary circle bordered by the Early Treatment Diabetic Retinopathy Study seven-standard fields...
October 2016: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/27715375/changes-in-the-macular-ganglion-cell-complex-thickness-and-central-macular-thickness-after-argon-laser-panretinal-photocoagulation
#12
Gülizar Demirok, Mehmet Fatih Kocamaz, Yasemin Topalak, Yeşim Altay, Burcu Tabakci, Ahmet Şengün
PURPOSE: To evaluate the changes in the macular ganglion cell complex (GCC) thickness and central macular thickness (CMT) as measured by spectral domain optical coherence tomography (OCT) post-argon laser panretinal photocoagulation (PRP). METHODS: The medical records of 25 patients with proliferative diabetic retinopathy (PDR) who underwent PRP, 29 patients with non-proliferative diabetic retinopathy (NPDR), and 29 patients with diabetes but without diabetic retinopathy (DR) were analyzed...
August 10, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27701631/improved-automated-detection-of-diabetic-retinopathy-on-a-publicly-available-dataset-through-integration-of-deep-learning
#13
Michael David Abràmoff, Yiyue Lou, Ali Erginay, Warren Clarida, Ryan Amelon, James C Folk, Meindert Niemeijer
Purpose: To compare performance of a deep-learning enhanced algorithm for automated detection of diabetic retinopathy (DR), to the previously published performance of that algorithm, the Iowa Detection Program (IDP)-without deep learning components-on the same publicly available set of fundus images and previously reported consensus reference standard set, by three US Board certified retinal specialists. Methods: We used the previously reported consensus reference standard of referable DR (rDR), defined as International Clinical Classification of Diabetic Retinopathy moderate, severe nonproliferative (NPDR), proliferative DR, and/or macular edema (ME)...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27700224/evidence-based-treatment-of-diabetic-retinopathy
#14
Hala El Rami, Rasha Barham, Jennifer K Sun, Paolo S Silva
Diabetic retinopathy (DR) is the most frequent microvascular complication from diabetes and requires annual screening and at least annual follow-up. A systemic approach to optimize blood glucose and blood pressure may halt progression to severe stages of DR and obviate the need for ocular treatment. Although there is evidence of benefit from fenofibrate or intravitreous antiVEGF treatment for eyes with nonproliferative DR (NPDR), these therapies are not standard care for NPDR at this time. Some patients with severe NPDR, especially those with type 2 diabetes, benefit from early panretinal photocoagulation (PRP)...
October 4, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27699408/automated-quantification-of-nonperfusion-in-three-retinal-plexuses-using-projection-resolved-optical-coherence-tomography-angiography-in-diabetic-retinopathy
#15
Miao Zhang, Thomas S Hwang, Changlei Dongye, David J Wilson, David Huang, Yali Jia
Purpose: The purpose of this study was to evaluate an automated algorithm for detecting avascular area (AA) in optical coherence tomography angiograms (OCTAs) separated into three individual plexuses using a projection-resolved technique. Methods: A 3 × 3 mm macular OCTA was obtained in 13 healthy and 13 mild nonproliferative diabetic retinopathy (NPDR) participants. A projection-resolved algorithm segmented OCTA into three vascular plexuses: superficial, intermediate, and deep...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27695284/noninvasive-detection-of-microaneurysms-in-diabetic-retinopathy-by-swept-source-optical-coherence-tomography
#16
Sarah Cheng, Theodore Leng
BACKGROUND AND OBJECTIVES: A method of identifying retinal vascular microaneurysms (MAs) in nonproliferative diabetic retinopathy (NPDR) using swept-source optical coherence tomography (SS-OCT). PATIENTS AND METHODS: SS-OCT images were acquired in 17 eyes with NPDR using prototype SS-OCT device and fluorescein angiography (FA) images were obtained simultaneously. MAs identified on SS-OCT slabs were correlated to MAs identified on FA. RESULTS: MAs were identified in SS-OCT slabs in 15/17 eyes, resulting in NPDR diagnosis rate of 88%...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27678201/aqueous-humour-concentrations-of-tgf-%C3%AE-plgf-and-fgf-1-and-total-retinal-blood-flow-in-patients-with-early-non-proliferative-diabetic-retinopathy
#17
Lee-Anne Khuu, Faryan Tayyari, Jeremy M Sivak, John G Flanagan, Shaun Singer, Michael H Brent, David Huang, Ou Tan, Christopher Hudson
PURPOSE: To correlate angiogenic cytokines in the aqueous humour with total retinal blood flow in subjects with type 2 diabetes with non-proliferative diabetic retinopathy (NPDR). METHODS: A total of 17 controls and 16 NPDR patients were recruited into the study. Aqueous humour was collected at the start of cataract surgery to assess the concentration of 14 angiogenic cytokines. Aqueous humour was analysed using the suspension array method. Six images were acquired to assess total retinal blood flow (TRBF) using the prototype RTVue(™) Doppler Fourier domain optical coherence tomography (Doppler FD-OCT) (Optovue, Inc...
September 28, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27627751/an-automatic-intercapillary-area-based-algorithm-for-quantifying-diabetes-related-capillary-dropout-using-optical-coherence-tomography-angiography
#18
Julia Schottenhamml, Eric M Moult, Stefan Ploner, ByungKun Lee, Eduardo A Novais, Emily Cole, Sabin Dang, Chen D Lu, Lennart Husvogt, Nadia K Waheed, Jay S Duker, Joachim Hornegger, James G Fujimoto
PURPOSE: To develop a robust, sensitive, and fully automatic algorithm to quantify diabetes-related capillary dropout using optical coherence tomography (OCT) angiography (OCTA). METHODS: A 1,050-nm wavelength, 400 kHz A-scan rate swept-source optical coherence tomography prototype was used to perform volumetric optical coherence tomography angiography imaging over 3 mm × 3 mm fields in normal controls (n = 5), patients with diabetes without diabetic retinopathy (DR) (n = 7), patients with nonproliferative diabetic retinopathy (NPDR) (n = 9), and patients with proliferative diabetic retinopathy (PDR) (n = 5); for each patient, one eye was imaged...
September 13, 2016: Retina
https://www.readbyqxmd.com/read/27588263/association-of-vascular-endothelial-growth-factor-634g-c-and-receptor-for-advanced-glycation-end-products-g82s-gene-polymorphisms-with-diabetic-retinopathy
#19
Asmaa Kamal, Khaled Abu Eleinen, Ibrahem Siam
AIM: To investigate the association of receptor for advanced glycation end products (RAGE) G82S and vascular endothelial growth factor (VEGF) -634 G/C gene polymorphisms with diabetic retinopathy (DR). METHODS: Our cross-sectional study included 61 diabetic patients, 12 of them had proliferative diabetic retinopathy (PDR), 15 had non proliferative diabetic retinopathy (NPDR), 34 had no diabetic retinopathy (NDR) and 61 healthy controls. Participants were tested for RAGE G82S and VEGF -634 G/C polymorphisms by polymerase chain reaction-restriction fragment length polymorphism...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27568125/effectiveness-of-the-multidisciplinary-risk-assessment-and-management-program-for-patients-with-diabetes-mellitus-ramp-dm-for-diabetic-microvascular-complications-a-population-based-cohort-study
#20
F Jiao, C S C Fung, Y F Wan, S M McGhee, C K H Wong, D Dai, R Kwok, C L K Lam
AIM: To evaluate the effectiveness of the multidisciplinary Risk Assessment and Management Program for Patients with Diabetes Mellitus (RAMP-DM) in reducing the risks of microvascular complications. METHODS: This prospective cohort study was conducted with 29,670 propensity-score-matched RAMP-DM participants and diabetes patients under the usual primary care (14,835 in each group). Study endpoints were the first occurrence of any diabetic microvascular complications, non-proliferative diabetic retinopathy/preproliferative diabetic retinopathy (NPDR/prePDR), sight-threatening diabetic retinopathy (STDR) or blindness, nephropathy, end-stage renal disease (ESRD), neuropathy and lower-limb ulcers or amputation...
August 24, 2016: Diabetes & Metabolism
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