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thyroid associated ophthalmopathy

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https://www.readbyqxmd.com/read/27893583/retinal-vessel-oxygen-saturation-and-vessel-diameter-in-inactive-graves-ophthalmopathy
#1
Xiaonan Yang, Danping Huang, Siming Ai, Xuanwei Liang, Jing Zhao, Lei Fang
PURPOSE: To investigate whether inactive thyroid-associated ophthalmopathy (TAO) affects retinal oxygen saturation and/or vessel diameter. METHODS: Via an observational case-control study, retinal circulation was measured in patients with inactive TAO (mild, moderate, and severe) and normal subjects by retinal oximetry. Complete ophthalmologic examination, including noncontact tonometry and Hertel exophthalmometry, was performed; history of smoking and dysthyroid disease were recorded...
November 23, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27877085/the-evolving-functions-of-autophagy-in-ocular-health-a-double-edged-sword
#2
REVIEW
Peiwei Chai, Hongyan Ni, He Zhang, Xianqun Fan
Autophagy plays an adaptive role in cell survival, development, differentiation and intracellular homeostasis. Autophagy is recognized as a 'self-cannibalizing' process that is active during stresses such as starvation, chemotherapy, infection, ageing, and oxygen shortage to protect organisms from various irritants and to regenerate materials and energy. However, autophagy can also lead to a form of programmed cell death distinct from apoptosis. Components of the autophagic pathway are constitutively expressed at a high level in the eye, including in the cornea, lens, retina, and orbit...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27832278/il-17a-promotes-rantes-expression-but-not-il-16-in-orbital-fibroblasts-via-cd40-cd40l-combination-in-thyroid-associated-ophthalmopathy
#3
Sijie Fang, Yazhuo Huang, Sisi Zhong, Yidan Zhang, Xingtong Liu, Yang Wang, Ping Gu, Huifang Zhou, Xianqun Fan
Purpose: This present study aims to investigate the phenotype of IL-17A-producing T cells in thyroid-associated ophthalmopathy (TAO) and the role of IL-17A on RANTES and IL-16 expression in orbital fibroblasts (OFs) from TAO patients. Methods: Blood samples were obtained from TAO patients and healthy controls and were subjected to ELISA and flow cytometry analysis. Primary human OFs cultured from surgical wastes were stimulated with IL-17A in the presence or absence of CD40L and were examined by qRT-PCR, ELISA, Western blotting, and apoptosis assays...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27829681/gender-dependent-and-age-of-onset-specific-association-of-the-rs11675434-single-nucleotide-polymorphism-near-tpo-with-susceptibility-to-graves-ophthalmopathy
#4
Aleksander Kuś, Konrad Szymański, Beata Jurecka-Lubieniecka, Edyta Pawlak-Adamska, Dorota Kula, Piotr Miśkiewicz, Marek Bolanowski, Rafał Płoski, Artur Bossowski, Jacek Daroszewski, Barbara Jarząb, Tomasz Bednarczuk
The role of TPO gene polymorphism in the susceptibility to Graves' disease (GD) remains unclear. However, single-nucleotide polymorphisms (SNPs) near TPO have been recently associated with serum levels of thyroid peroxidase (TPO) antibody in two independent genome-wide association studies. Moreover, we have observed a strong association between the rs11675434 SNP located near TPO and the presence of clinically evident Graves' ophthalmopathy (GO). The aim of the current study was to reevaluate and dissect this association in an extended group of 1231 well-characterized patients with GD (1043 adults and 188 children) and 1130 healthy controls from the Polish Caucasian population, considering possible gender-dependent and age-of-onset-specific effects of the studied SNP...
November 10, 2016: Journal of Human Genetics
https://www.readbyqxmd.com/read/27768856/elevated-serum-tetrac-in-graves-disease-potential-pathogenic-role-in-thyroid-associated-ophthalmopathy
#5
Roshini Fernando, Ekaterina Placzek, Edmund A Reese, Andrew T Placzek, Samantha Schwartz, Aaron Trierweiler, Leslie M Niziol, Stephen Atkins, Thomas S Scanlan, Terry J Smith
CONTEXT: The sources and biological impact of 3,3',5,5' tetraiodothyroacetic acid (TA4) are uncertain. CD34(+) fibrocytes express several proteins involved in the production of thyroid hormones. They infiltrate the orbit in Graves' disease (GD), an autoimmune process known as thyroid-associated ophthalmopathy. It appears that the thyrotropin receptor (TSHR) plays an important role in the pathogenesis of TAO. OBJECTIVE: To quantify levels of TA4 in healthy subjects and those with Graves' disease...
October 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27730666/pre-tibial-mixedema-a-case-report-with-scanning-electron-microscopy
#6
R R da Cunha Filho, H L de Almeida, J D Basei, R H Camina, L A S de Castro
Pretibial myxedema (PTM) results from the accumulation of hyaluronic acid in the dermis and subcutis and is commonly associated with Graves' disease (GD). It occurs in up to 5% of patients with GD and in 13% of patients with GD and ophthalmopathy. PTM occasionally occurs in thyrotoxicosis but is much less frequently in patients with Hashimoto thyroiditis, primary hypothyroidism and euthyroidism. This article is protected by copyright. All rights reserved.
October 12, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27729751/the-change-of-lacrimal-gland-volume-in-korean-patients-with-thyroid-associated-ophthalmopathy
#7
Hyoun-Do Huh, Ji-Hye Kim, Seong-Jae Kim, Ji-Myong Yoo, Seong-Wook Seo
PURPOSE: To describe the change of lacrimal gland volumes in Korean patients with thyroid-associated ophthalmopathy (TAO) via computed tomography (CT). METHODS: A retrospective review of CT images from 217 TAO patients and 135 control subjects was performed. The TAO patients were diagnosed between May 2005 and May 2014 and had a CT performed on initial presentation (330 orbital CT scans). These images were compared with 270 orbital CT scans from the control group, obtained between May 2013 and May 2014...
October 2016: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/27682712/an-update-on-thyroid-associated-ophthalmopathy-in-children-and-adolescents
#8
Justyna Szczapa-Jagustyn, Anna Gotz-Więckowska, Jarosław Kocięcki
BACKGROUND: Risk of developing thyroid-associated ophthalmopathy (TAO) in children and adolescents is similar or may be even slightly higher than in adults. The aim of this article is to review and summarize current knowledge regarding diagnostic and therapeutic measures in pediatric TAO. CONTENT: MEDLINE and EMBASE papers were searched using the terms 'pediatric Graves' ophthalmopathy' 'pediatric Graves' orbitopathy', 'thyroid-associated ophthalmopathy in childhood and adolescence' from the year 1970 to December 2015...
October 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27631497/cd40-expression-in-fibrocytes-is-induced-by-tsh-potential-synergistic-immune-activation
#9
Tünde Mester, Nupur Raychaudhuri, Erin F Gillespie, Hong Chen, Terry J Smith, Raymond S Douglas
CONTEXT: Fibrocytes appear to participate in inflammation and tissue remodeling in patients with thyroid-associated ophthalmopathy (TAO). These patients have increased frequencies of circulating TSH receptor (TSHR)- and CD40-positive fibrocytes, suggesting TSHR and CD40 may play roles in proinflammatory cytokine production, which ultimately leads to orbital inflammation and tissue remodeling. OBJECTIVE: To investigate the potential interactions between the TSHR and CD40 signaling pathways and their roles in IL-6 and TNF-α production...
2016: PloS One
https://www.readbyqxmd.com/read/27612658/thyrotropin-and-cd40l-stimulate-interleukin-12-expression-in-fibrocytes-implications-for-pathogenesis-of-thyroid-associated-ophthalmopathy
#10
Tong Wu, Tünde Mester, Shivani Gupta, Fengyuan Sun, Terry J Smith, Raymond S Douglas
BACKGROUND: Increased numbers of bone marrow-derived progenitor cells, known as fibrocytes, populate the peripheral circulation, orbit, and thyroid of patients with Graves' disease (GD). These cells have been implicated in the development of thyroid-associated ophthalmopathy. They can differentiate into myofibroblasts or adipocytes, produce inflammatory cytokines, and remodel tissue. This study sought to determine whether thyrotropin (TSH) and CD40 ligand (CD40L), implicated in the pathogenesis of GD, induce interleukin-12 (IL-12) in human fibrocytes...
October 18, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27580012/constitutively-low-expression-of-collagen-xiii-alpha-1-may-help-explain-the-vulnerability-of-the-inferior-rectus-muscle-to-thyroid-associated-ophthalmopathy
#11
Olivia Claire Morris, Kirsten Schebitz Walter, Esbjörn Telemo, Christoph Hintschich
Thyroid-associated ophthalmopathy (TAO) has a predilection for inferior rectus muscle that has never been explained. We conducted immunohistochemical staining for the soluble cleaved form of collagen XIII alpha 1 (COL13A1) and found constitutively low expression of COL13A1 in normal human inferior rectus muscles and moderate expression of COL13A1 in normal human medial rectus muscles. COL13A1 is known to be essential to development and maintenance of neuromuscular junctions and there is some evidence to suggest it may help support normal immune function...
August 31, 2016: Orbit
https://www.readbyqxmd.com/read/27543288/expression-and-clinical-significance-of-connective-tissue-growth-factor-ctgf-in-graves-ophthalmopathy
#12
Yi-Ming Huang, Pei-Chen Chang, Shi-Bei Wu, Hui-Chuan Kau, Chieh-Chih Tsai, Catherine Jui-Ling Liu, Yau-Huei Wei
AIMS: To examine the expression of connective tissue growth factor (CTGF) in human cultured orbital fibroblasts from patients with Graves' ophthalmopathy (GO) and investigate whether a correlation exists between the presence of CTGF protein and clinical parameters of the disease. METHODS: The protein expression levels of CTGF were analysed by western blots in cultured orbital fibroblasts from 10 patients with GO and 7 age-matched normal controls. Associations between the protein expression of CTGF and the clinical factors of GO, including clinical demographics, thyroid function, clinical activity score (CAS) and ophthalmopathy index (OI), was evaluated...
August 19, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27534827/efficacy-and-safety-of-radioiodine-therapy-for-mild-graves-ophthalmopathy-in-dependence-on-cigarette-consumption-a-half-year-of-follow-up
#13
Agata Czarnywojtek, Krzesisława Komar-Rychlicka, Małgorzata Zgorzalewicz-Stachowiak, Nadia Sawicka-Gutaj, Kosma Woliński, Paweł Gut, Maria Płazinska, Barbara Torlińska, Ewa Florek, Joanna Waligórska-Stachura, Marek Ruchała
INTRODUCTION    Graves' Orbitopathy (GO) is an autoimmune disease associated with Graves' disease. Therapy is largely dependent on the severity and activity of ocular changes. Particular attention should be given to radioiodine therapy (RIT). Although its application is a valuable method of the treatment of hyperthyroidism, it may be followed by worsening of GO. OBJECTIVES    The aim of the present article is to indicate how the severity of nicotine addiction influences the response for RAI treatment in GO patients...
August 18, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27493796/optic-disc-macula-and-retinal-nerve-fiber-layer-measurements-obtained-by-oct-in-thyroid-associated-ophthalmopathy
#14
Osman Sayın, Volkan Yeter, Nurşen Arıtürk
Aim. To compare the measurements of retinal nerve fiber layer (RNFL), macula and optic disc parameters obtained by optical coherence tomography (OCT), and intraocular pressure (IOP) between the patients with thyroid-associated ophthalmopathy (TAO) and healthy controls. Methods. One hundred and thirty-two eyes of 66 patients with TAO and 72 eyes of 36 healthy controls were included in the study. Proptosis level was determined by Hertel exophthalmometer. Optic disc, peripapillary retinal nerve fiber layer, and macula parameters were measured by OCT...
2016: Journal of Ophthalmology
https://www.readbyqxmd.com/read/27486433/association-studies-of-the-gpr103-and-bcl2l15-genes-in-autoimmune-thyroid-disease-in-the-japanese-population
#15
Yoshiyuki Ban, Teruaki Tozaki, Yasuko Nakano
While the past genome-wide association study (GWAS) for autoimmune thyroid diseases (AITDs) was done in Caucasians, a recent GWAS in Caucasian patients with both AITD and type 1 diabetes [a variant of autoimmune polyglandular syndrome type 3 (APS3v)] identified five non-HLA genes: BCL2L15, MAGI3, PHTF1, PTPN22, and GPR103. The aim of our study was to replicate these associations with AITD in a Japanese population. Since analyzing the rs2476601 single-nucleotide polymorphism (SNP) within the PTPN22 gene revealed no polymorphism in the Japanese, we analyzed four SNPs, rs2358994 (in BCL2L15), rs2153977 (in MAGI3), rs1111695 (in PHTF1), and rs7679475 (in GPR103) genotypes in a case-control study based on 447 Japanese AITD patients [277 Graves' disease (GD) and 170 Hashimoto's thyroiditis (HT) patients] and 225 matched Japanese controls using the high-resolution melting and unlabeled probe methods...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27484716/celastrol-inhibits-il-1%C3%AE-induced-inflammation-in-orbital-fibroblasts-through-the-suppression-of-nf-%C3%AE%C2%BAb-activity
#16
Hong Li, Yifei Yuan, Yali Zhang, Qianwen He, Rongjuan Xu, Fangfang Ge, Chen Wu
Graves' disease is an autoimmune disease of the thyroid gland, which is characterized by hyperthyroidism, diffuse goiter and Graves' ophthalmopathy (GO). Although several therapeutic strategies for the treatment of GO have been developed, the effectiveness and the safety profile of these therapies remain to be fully elucidated. Therefore, examination of novel GO therapies remains an urgent requirement. Celastrol, a triterpenoid isolated from traditional Chinese medicine, is a promising drug for the treatment of various inflammatory and autoimmune diseases...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27471912/intersection-of-chemokine-and-tsh-receptor-pathways-in-human-fibrocytes-emergence-of-cxcl-12-cxcr4-cross-talk-potentially-relevant-to-thyroid-associated-ophthalmopathy
#17
Roshini Fernando, Stephen J Atkins, Terry J Smith
Fibrocytes are monocyte progenitor cells that have been implicated in normal and pathological tissue remodeling. Among the prominent chemokine receptors expressed by these cells is CXC motif receptor 4 (CXCR4), which, with its cognate ligand CXCL motif ligand 12 (CXCL-12), directs fibrocytes to sites of fibrosis. Fibrocytes have been implicated in the pathogenesis of thyroid-associated ophthalmopathy, the ocular manifestation of Graves' disease (GD), by virtue of their unique accumulation as CD34(+) orbital fibroblasts (OFs)...
October 2016: Endocrinology
https://www.readbyqxmd.com/read/27468480/-the-study-of-lipofibroblasts-differentiation-of-cd90%C3%A2-%C2%BA-and-cd90%C3%A2-orbital-fibroblasts-subsets-in-patients-with-tao
#18
Lu Gan, Qing-li Luo, Fei Tang, Wen-wen Wu, Li Tang
OBJECTIVE: Divided orbital fibroblasts from patients with thyroid-associated ophthalmopathy (TAO) into CD90⁺ and CD90⁻ subsets respect to surface CD90 expression, then determined whether CD90⁺ and/or CD90⁻ fibroblasts were capable of differentiating into lipofibroblasts. METHODS: Fibroblasts subset separation into CD90⁺ and CD90⁻ subsets was accomplished by three to four rounds of magnetic bead selection, then treated with 3-isobutyl-1-lmethylxanthine (IBMX), insulin and dexamethasone which was an known inducer of the lipofibroblastic phenotype, then the cells were observed every day to find Lipid droplets...
May 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/27468062/images-in-clinical-medicine-thyroid-ophthalmopathy-dermopathy-and-acropachy
#19
Carlo Guerrero, Mark R Pittelkow
A 56-year-old man was referred to a dermatologist for assessment of the progression of his thyroid dermopathy. Three years earlier he had received a diagnosis of Graves’ disease with thyroid-associated ophthalmopathy and dermopathy. He was treated with radioactive iodine ablation. Photographs taken..
July 21, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27465319/association-of-polymorphisms-of-rs179247-and-rs12101255-in-thyroid-stimulating-hormone-receptor-intron-1-with-an-increased-risk-of-graves-disease-a-meta-analysis
#20
Jing Gong, Shu-Jun Jiang, Ding-Kun Wang, Hui Dong, Guang Chen, Ke Fang, Jin-Rui Cui, Fu-Er Lu
The polymorphisms of thyroid stimulating hormone receptor (TSHR) intron 1 rs179247 and rs12101255 have been found to be associated with Graves' disease (GD) in genetic studies. In the present study, we conducted a meta-analysis to examine this association. Two reviewers systematically searched eligible studies in PubMed, Web of Science, Embase and China Biomedical Literature Database (CBM). A meta-analysis on the association between GD and TSHR intron 1 rs179247 or rs12101255 was performed. The odd ratios (OR) were estimated with 95% confidence interval (CI)...
August 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
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