keyword
https://read.qxmd.com/read/38542262/the-role-of-fibrogenesis-and-extracellular-matrix-proteins-in-the-pathogenesis-of-graves-ophthalmopathy
#1
REVIEW
Hsun-I Chiu, Shi-Bei Wu, Chieh-Chih Tsai
Graves' ophthalmopathy (GO), or thyroid eye disease (TED), is the most frequent extrathyroidal manifestation of Graves' disease (GD). Inflammation and subsequent aberrant tissue remodeling with fibrosis are important pathogenesis. There are many proposed mechanisms and molecular pathways contributing to tissue remodeling and fibrosis in GO, including adipogenesis, fibroblast proliferation and myofibroblasts differentiation, oxidative stress, endoplasmic reticulum (ER) stress, hyaluronan (HA) and glycosaminoglycans (GAGs) accumulation in the extracellular matrix (ECM) and new concepts of epigenetics modification, such as histone modification, DNA methylation, non-coding RNAs, and gut microbiome...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38513158/pearls-oy-sters-thyroid-associated-ophthalmopathy-and-transient-neuromuscular-junction-disorder-due-to-graves-disease
#2
JOURNAL ARTICLE
Vasiliki Zouvelou, Elli M Petrou, Eleni Strataki, Vasiliki Vasileiou, Georgios Velonakis
The concomitant presentation of thyroid-associated ophthalmopathy (TAO) and ocular myasthenia gravis is well documented. In the course of Graves disease (GD), symptomatic transient neuromuscular junction disorder may occur due to the effect of thyroid hormones at the neuromuscular synapse. Diagnostic clues are the clinical and electrophysiologic remission synchronous with restoration of euthyroidism. Furthermore, the occurrence of thymic hyperplasia in GD poses further diagnostic and therapeutic considerations...
April 23, 2024: Neurology
https://read.qxmd.com/read/38509387/monocyte-to-high-density-lipoprotein-ratio-and-systemic-immune-inflammation-index-potential-parameters-for-the-evaluation-of-disease-activity-and-severity-in-graves-ophthalmopathy
#3
JOURNAL ARTICLE
Büşra Yılmaz Tuğan, Abdullah Ergen, Berna Özkan
PURPOSE: To assess changes in monocyte-to-high-density lipoprotein (HDL) ratio (MHR), neutrophil-to-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII) with Graves' ophthalmopathy (GO) and their possible relation with GO disease activity and severity. METHODS: A total of 20 patients with GO and 24 healthy controls were involved in the study. The thyroid status, MHR (monocyte count/HDL cholesterol level), NLR (neutrophil count/lymphocyte count) and SII [(neutrophil count × platelet count)/lymphocyte count] were compared between the groups...
March 21, 2024: International Ophthalmology
https://read.qxmd.com/read/38462379/-research-status-of-potential-therapeutic-targets-for-thyroid-associated-ophthalmopathy
#4
JOURNAL ARTICLE
J H Yu, Y H Wang, H F Liao
Thyroid-associated ophthalmopathy (TAO) is an autoimmune eye disease that affects visual function and appearance, involving pathological remodeling processes of orbital tissue such as inflammatory reaction, oxidative stress, lipogenesis, and fibrosis. Current clinical first-line treatment options cannot be effective for all patients. This article summarizes the research on potential therapeutic targets of TAO at home and abroad in recent years, including receptor protein targets, immune cell targets, fat suppression targets, anti-fibrosis targets, transcription factor targets, and metabolic regulatory enzyme targets...
March 11, 2024: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://read.qxmd.com/read/38448333/initial-implementation-of-surgical-guide-design-utilizing-digital-medicine-for-lateral-orbital-decompression-surgery
#5
JOURNAL ARTICLE
Jinhai Yu, Zexi Sang, Zhangjun Ren, Qihua Xu, Yaohua Wang, Hongfei Liao
This study aimed to assess the feasibility of utilizing a surgical guide, designed through digital medical technology, in lateral orbital decompression surgery. METHODS: In total, 18 patients with thyroid-associated ophthalmopathy (TAO), who underwent orbital balance decompression surgery at the Affiliated Eye Hospital of Nanchang University between September 2018 and August 2022, were included. Orbital CT scanning was performed on all patients with TAO, and Mimics 21.0 software was used to reconstruct a three-dimensional model of the orbit based on the CT data...
February 19, 2024: Journal of Cranio-maxillo-facial Surgery
https://read.qxmd.com/read/38444235/euthyroid-graves-ophthalmopathy-in-a-chinese-population-a-cross-sectional-follow-up-study
#6
JOURNAL ARTICLE
Kenneth Kh Lai, Fatema Mohamed Ali Abdulla Aljufairi, Jake Uy Sebastian, Joyce Ky Chin, Eric Kh Choy, Annika Hl Yiu, Alan Ch Lee, C M Ng, Wilson Wk Yip, Alvin L Young, Hunter Kl Yuen, Clement Cy Tham, Chi Pui Pang, Kelvin Kl Chong
OBJECTIVES: A subtype of patients with thyroid eye disease (TED) were found to be euthyroid without prior thyroid dysfunction or treatment, known as Euthyroid Graves' Ophthalmopathy (EGO). We report the prevalence, clinical and serological phenotypes of EGO in a Chinese population. METHODS: A cross-sectional follow-up study. Ethnic Chinese TED patients were managed at the Thyroid Eye Clinic(TEC), Prince of Wales Hospital and TEC, the Chinese University of Hong Kong between September 2007 and July 2021...
March 5, 2024: European Journal of Ophthalmology
https://read.qxmd.com/read/38441857/effect-of-intraorbital-mechanical-compression-on-retinal-microvascular-perfusion-in-quiescent-thyroid-associated-ophthalmopathy-based-on-ocular-biomechanics-measured-by-corvis-st
#7
JOURNAL ARTICLE
Wei Fang, Ziyun Zhou, Zhenbin Qian, Mengdi Wang, Fangjun Bao, Lijun Shen
INTRODUCTION: To analyze the correlation between orbital compliance and retinal vessel density (VD) based on dynamic Scheimpflug analyzer (Corvis ST) and optical coherence tomographic angiography (OCT-A). METHODS: In this prospective observational study, 65 eyes of 44 patients with thyroid-associated ophthalmopathy (TAO) in quiescent stage were included (15 males and 29 females). The whole eye movement (WEM) was detected by Corvis ST. The superficial capillary plexus VD (SCP-VD) and deep capillary plexus VD (DCP-VD) were obtained by scanning the 3 × 3 mm area around the fovea using OCT-A, while the peripapillary vessel density (ppVD) was obtained by scanning the 4...
March 5, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38432867/gut-microbiota-and-thyroid-associated-ophthalmopathy
#8
JOURNAL ARTICLE
Jingxiao Zhao, Ping Wang, Minmin Jiang, Shuxun Yan
Thyroid-associated ophthalmopathy (TAO) is a multifactorial-mediated autoimmune orbital disease with the highest incidence of orbital disease in adults. Due to the complex clinical manifestations and prolonged course,TAO seriously affect the physical and mental health of patients.The pathogenesis of TAO has not been fully elucidated and the treatment lacks specificity. Therefore, in-depth research on the pathogenesis of TAO is to find effective treatments. In recent years, studies have suggested that there is gut microbiota disorder in TAO, and the risk factors of TAO can promote gut microbiota disorder...
November 28, 2023: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/38430354/ocular-surface-and-meibomian-gland-evaluation-in-euthyroid-graves-ophthalmopathy
#9
JOURNAL ARTICLE
Kenneth Ka Hei Lai, Xulin Liao, Fatema Mohamed Ali Abdulla Aljufairi, Jake Uy Sebastian, Andre Ma, Yiu Man Wong, Cheuk Lam Lee, Wanxue Chen, Zhichao Hu, George P M Cheng, Clement C Tham, Chi Pui Pang, Kelvin K L Chong
PURPOSE: Euthyroid Graves' ophthalmology (EGO) refers to the subgroup of thyroid eye disease patients with distinct clinical presentations. This study evaluated the ocular surface and meibomian gland changes in EGO patients. METHODS: A cross-sectional study was conducted at The Chinese University of Hong Kong including 34 EGO patients and 34 age-and sex- matched healthy controls. Outcome measures include anterior segment examination, keratographic and meibographic imaging...
March 2, 2024: International Ophthalmology
https://read.qxmd.com/read/38401453/semi-supervised-segmentation-of-orbit-in-ct-images-with-paired-copy-paste-strategy
#10
JOURNAL ARTICLE
Wentao Li, Hong Song, Danni Ai, Jieliang Shi, Yuanyuan Wang, Wencan Wu, Jian Yang
The segmentation of the orbit in computed tomography (CT) images plays a crucial role in facilitating the quantitative analysis of orbital decompression surgery for patients with Thyroid-associated Ophthalmopathy (TAO). However, the task of orbit segmentation, particularly in postoperative images, remains challenging due to the significant shape variation and limited amount of labeled data. In this paper, we present a two-stage semi-supervised framework for the automatic segmentation of the orbit in both preoperative and postoperative images, which consists of a pseudo-label generation stage and a semi-supervised segmentation stage...
February 19, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38401100/preliminary-study-on-the-correlation-between-episcleral-venous-pressure-and-intraocular-pressure-in-tao-patients-and-its-clinical-value
#11
JOURNAL ARTICLE
Xinyu Fan, Xu Zha, Ning Wang, Yuanhui Han
OBJECTIVE: To study the correlation between episcleral vein pressure (EVP) with intraocular pressure (IOP), exophthalmos, and optic nerve injury in thyroid-associated ophthalmopathy (TAO) patients and to explore the possibility of higher EVP as an intervention indicator in TAO patients. METHODS: This study was a case-control study, including the TAO group and normal control group. TAO group: 15 patients (30 eyes) were diagnosed with TAO complicated with exophthalmos...
February 9, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38375285/immunoglobulin-g4-related-thyroiditis-associated-with-graves-disease-a-case-report
#12
Hiroyuki Takahashi, Sabine Kajita, Hiroshi Katoh, Toshihide Matsumoto, Akemi Inoue, Takafumi Sangai, Makoto Saegusa
We report a case of immunoglobulin (ig)-g4-related thyroiditis associated with graves' disease. a 45-year-old man was diagnosed with graves' disease due to asymptomatic enlarged thyroid gland and high serum levels of thyrotropin receptor antibodies and thyroid hormones. surgical resection of the thyroid gland was performed because of further thyroid gland enlargement and severe fluctuations in the thyroid hormonal levels, despite medical therapy with a combination of an antithyroid drug and a thyroid hormone preparation...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38358400/a-meta-analysis-of-the-efficacy-of-two-wall-orbital-decompression-operations-for-thyroid-associated-ophthalmopathy
#13
REVIEW
Yu Jinhai, Chen Yunxiu, Xiong Chao, Wang Yaohua, Yuan Kai, Liao Hongfei
BACKGROUND: The main treatment for the symptoms of proptosis and optic nerve compression caused by thyroid-associated ophthalmopathy is orbital decompression surgery. Medial inferior wall decompression and balanced decompression are two frequently used surgical procedures. However, there is no unified consensus on how to choose different surgical options for orbital decompression in clinical practice. AIMS: To compare the effects of medial inferior wall decompression and balanced decompression surgery through meta-analysis and to provide reference for clinical optimal decision making...
February 15, 2024: International Ophthalmology
https://read.qxmd.com/read/38350897/correlation-between-choroidal-vascularity-and-retrobulbar-ocular-blood-flow-changes-and-thyroid-associated-ophthalmopathy-activity-a-cross-sectional-study
#14
JOURNAL ARTICLE
Xinghong Sun, Mengru Su, Xiaowen Zhang, Haiyun Shen, Zhenggao Xie, Wentao Kong, Dandan Zhu
OBJECTIVE: To evaluate the alterations in retrobulbar color Doppler imaging (CDI) parameters and retinal/choroidal optical coherence tomography angiography (OCTA) parameters and their association with the clinical activity and severity in thyroid-associated orbitopathy (TAO) patients. METHODS: In this study, the retrobulbar flow parameters including resistance index (RI), Pulsatile Index(PI), peak systolic velocity (PSV) and end diastolic velocity (EDV) in posterior ciliary artery (PCA), central retinal artery (CRA) and ophthalmic artery (OA) were determined by CDI...
February 13, 2024: BMC Ophthalmology
https://read.qxmd.com/read/38342593/intermittent-fasting-and-vitamin-e-supplementation-attenuates-hypothyroidism-associated-ophthalmopathy
#15
JOURNAL ARTICLE
Nirdesh Kumar, Ashmita Das, Nidhi Kumari, Geeta Singh, Urvashi Jain, Amrita Singh, Surendra H Bodakhe
Visualization is a complex-integrated procedure of the eyes and brain that allows to see this colorful world. Hypothyroidism-associated ophthalmopathy (HAO), often known as dry eyes, swelling around the eyes, blurred vision, glaucoma, and cataracts, are some eye-related issues caused by hypothyroidism. Yet there is no permanent cure for hypothyroidism; taking medicine throughout life is the only solution to keep its harmful effects under control. This study used intermittent fasting (IF) and vitamin E (Vit...
February 11, 2024: Molecular Nutrition & Food Research
https://read.qxmd.com/read/38341128/bridging-and-validation-of-the-specific-graves-ophthalmopathy-quality-of-life-go-qol-questionnaire-with-health-state-utility-values
#16
JOURNAL ARTICLE
Terry J Smith, Kimberly Cockerham, Naina Barretto, Alex Hirst, Louisa Oliver, Ashley Enstone, Giulia Brandolini, Stephanie D Taylor, Robert J Holt
OBJECTIVE: In thyroid eye disease (TED) inflammation and expansion of orbital muscle and peri-orbital fat produce diplopia and proptosis, severely impacting patient quality of life (QOL). Reported heath state utility (HSU) scores, which are QOL measures, allow quantification of TED impact and improvement with therapies; however, no current QOL instrument has been validated with HSU scores for TED. Here we use disease-specific Graves' ophthalmopathy (GO)-QOL questionnaire and HSU scores to validate QOL impact...
February 8, 2024: Endocrine Practice
https://read.qxmd.com/read/38315295/artificial-intelligence-based-quantitative-evaluation-of-retinal-vascular-parameters-in-thyroid-associated-ophthalmopathy
#17
JOURNAL ARTICLE
Xue Jiang, Li Dong, Lihua Luo, Dengji Zhou, Saiguang Ling, Dongmei Li
PURPOSE: Thyroid-associated ophthalmopathy (TAO) may result in increased metabolism and abnormalities in microcirculation. The fractal dimension (Df) of retinal vessels has been shown to be related to the pathology of a number of ophthalmic disorders, but it hasn't been investigated in TAO. METHODS: We analyzed 1078 participants aged 18 to 72 (548 healthy volunteers and 530 TAO). Images were captured using a non-mydriatic 45-degree fundus camera. Baseline retinal characteristics, such as vessel width, tortuosity, and Df were measured using semiautomated software from fundus images...
February 3, 2024: Endocrine
https://read.qxmd.com/read/38298177/altered-static-and-dynamic-brain-functional-topological-organization-in-patients-with-dysthyroid-optic-neuropathy
#18
JOURNAL ARTICLE
Jiang Zhou, Wen Chen, Wen-Hao Jiang, Qian Wu, Jin-Ling Lu, Huan-Huan Chen, Hu Liu, Xiao-Quan Xu, Fei-Yun Wu, Hao Hu
CONTEXT: Dysthyroid optic neuropathy (DON) is a serious vision-threatening complication of thyroid-associated ophthalmopathy (TAO). Exploration of the underlying mechanisms of DON is critical for its timely clinical diagnosis. OBJECTIVE: We hypothesized that TAO patients with DON may have altered brain functional networks. We aimed to explore the alterations of static and dynamic functional connectomes in patients with and without DON using resting-state functional MRI with graph theory method...
January 31, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38276980/diagnosis-of-dysthyroid-optic-neuropathy-combined-value-of-orbital-mri-and-intracranial-visual-pathway-diffusion-kurtosis-imaging
#19
JOURNAL ARTICLE
Hao Hu, Jiang Zhou, Wen-Hao Jiang, Qian Wu, Xiong-Ying Pu, Hu Liu, Huan-Huan Chen, Xiao-Quan Xu, Fei-Yun Wu
OBJECTIVES: To evaluate the combined performance of orbital MRI and intracranial visual pathway diffusion kurtosis imaging (DKI) in diagnosing dysthyroid optic neuropathy (DON). METHODS: We retrospectively enrolled 61 thyroid-associated ophthalmopathy (TAO) patients, including 25 with DON (40 eyes) and 36 without DON (72 eyes). Orbital MRI-based apical muscle index (MI), diameter index (DI) of the optic nerve (ON), area index (AI) of the ON, apparent diffusion coefficient (ADC) and signal intensity ratio (SIR) of the ON, DKI-based kurtosis fractional anisotropy (KFA) and mean kurtosis (MK) of the optic tract (OT), optic radiation (OR), and Brodmann areas (BAs) 17, 18, and 19 were measured and compared between groups...
January 26, 2024: European Radiology
https://read.qxmd.com/read/38266604/early-diagnosis-of-thyroid-associated-ophthalmopathy-using-label-free-raman-spectroscopy-and-multivariate-analysis
#20
JOURNAL ARTICLE
Zhihong Wang, Weiming Lin, Chenyu Luo, Honghua Xue, Tingyin Wang, Jianzhang Hu, Zufang Huang, Desheng Fu
Thyroid-associated ophthalmopathy (TAO) is the most common orbital disease in adults, with complex clinical manifestations and significant impacts on the life quality of patients. The current diagnosis of TAO lacks reliable biomarkers for early and non-invasive screening and detection, easily leading to poor prognosis. Therefore, it is essential to explore new methods for accurately predicting TAO development in its early stage. In this study, Raman spectroscopy, with non-destructive, label-free, and high-sensitivity characteristics, was used to analyze the differences in biochemical components of orbital adipocyte and tear samples between TAO and control groups...
January 19, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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