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thyroid associated ophthalmopathy

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https://www.readbyqxmd.com/read/29675428/ptx3-a-potential-biomarker-in-thyroid-associated-ophthalmopathy
#1
Pei Mou, Ziyu Chen, Lihong Jiang, Jinwei Cheng, Ruili Wei
Background: Thyroid associated ophthalmopathy (TAO) is an autoimmune disease, which involves inflammation and tissue remodeling. Pentraxin-3 (PTX3) is a component of innate immune system and recently implicated in autoimmunity. This observation may indicate that PTX3 participates in the inflammatory process of TAO. Methods: All studies were performed on TAO patients and healthy controls (45: 28 in total). RNA-seq was used to detect differential gene expression of orbital adipose-connective tissue...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29643678/metabolic-bone-superscan-in-carcinoma-breast-with-occult-graves-disease-looking-beyond-skeletal-metastases
#2
Ashwin Singh Parihar, Ashwani Sood, Tinu Thadiyananickal Lukose, Rajeev Kumar Seam, Bhagwant Rai Mittal
Extrathyroidal manifestations of autoimmune thyroid disorders include thyroid-associated ophthalmopathy, thyroid dermopathy, and thyroid acropachy. Thyroid acropachy is an extreme manifestation of autoimmune thyroid disorder characterized by clubbing and swelling of fingers and toes, with or without periosteal reaction of the distal bones. We present a 50-year-old woman, posttreatment for carcinoma breast (6 years back) and referred for bone scan for generalized body ache. Bone scan findings resulting in detailed clinical evaluation prompted toward the suspicion of a thyroidal disease with ultimate diagnosis of Graves' disease...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29546054/serum-trace-elements-profile-in-graves-disease-patients-with-or-without-orbitopathy-in-northeast-china
#3
Yongping Liu, Shanshan Liu, Jinyuan Mao, Sichen Piao, Jing Qin, Shiqiao Peng, Xiaochen Xie, Haixia Guan, Yushu Li, Zhongyan Shan, Weiping Teng
Objective: The purpose of the present study was to investigate serum trace elements in Graves' disease (GD) patients with or without orbitopathy in Northeast China. Methods: Patients with newly diagnosed Graves' disease (HyGD) ( n = 66), GD patients with euthyroid status or subclinical thyroidism after treatment (EUGD) ( n = 55), GO patients with euthyroid status or subclinical thyroidism after treatment (GO) ( n = 57), and normal controls (NC) ( n = 66) were enrolled in this study...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29521049/elevated-serum-concentrations-of-metalloproteinases-mmp-2-mmp-9-and-their-inhibitors-timp-1-timp-2-in-patients-with-graves-orbitopathy
#4
Katarzyna Kapelko-Słowik, Mirosław Słowik, Marek Szaliński, Jarosław Dybko, Dariusz Wołowiec, Iwona Prajs, Anna Bohdanowicz-Pawlak, Monika Biernat, Donata Urbaniak-Kujda
BACKGROUND: Graves' orbitopathy (GO), also known as thyroid-associated ophthalmopathy, is characterized by dramatic tissue reactivity. Both inflammation and tissue remodeling characterize the clinical course of GO. Some data has been found regarding the association of MMPs and TIMPs in GO. MATERIAL AND METHODS: Serum concentrations of MMP-9, MMP-2, TIMP-1, and TIMP-2 were determined by ELISA method. OBJECTIVES: Forty-eight patients (34 females, 14 males, with median age 51...
January 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29463244/a-single-center-retrospective-study-of-factors-related-to-the-effects-of-intravenous-glucocorticoid-therapy-in-moderate-to-severe-and-active-thyroid-associated-ophthalmopathy
#5
Yang Wang, Shuo Zhang, Yidan Zhang, Xingtong Liu, Hao Gu, Sisi Zhong, Yazhuo Huang, Sijie Fang, Jing Sun, Huifang Zhou, Xianqun Fan
BACKGROUND: Intravenous glucocorticoids (ivGC) have been recommended as a first-line treatment of moderate-to-severe and active thyroid-associated ophthalmopathy (TAO). However, not all patients are responsive to ivGC. The identification of potential factors used to predict their efficacy and the selection of suitable patients have both been lacking. METHODS: It was a single center retrospective study. Potential factors related to the effects of ivGC were analyzed using logistic regression in 90 consecutive patients with moderate-to-severe and active TAO, who received 4...
February 20, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29452583/does-rituximab-improve-clinical-outcomes-of-patients-with-thyroid-associated-ophthalmopathy-a-systematic-review-and-meta-analysis
#6
Changjun Wang, Qingyao Ning, Kai Jin, Jiajun Xie, Juan Ye
BACKGROUND: The current therapies of thyroid-associated ophthalmopathy (TAO) were still a challenging matter. In this study, we aimed to contrast the impact of before- after rituximab (RTX) therapy in the patients with TAO. METHODS: We searched the PubMed, EMBASE, and SCOPUS databases for articles published up to July 3, 2017. Fixed- or random-effects meta-analysis was used to provide pooled estimates of standard mean difference (SMD) both the primary outcome from clinical activity score (CAS), and secondary outcomes from thyrotropin receptor antibody (TRAb), proptosis, thyroid stimulating hormone (TSH), and interleukin-6 (IL-6) levels...
February 17, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29412482/establishment-of-mri-3d-reconstruction-technology-of-orbital-soft-tissue-and-its-preliminary-application-in-patients-with-thyroid-associated-ophthalmopathy
#7
Jie Shen, Wei Jiang, Yaosheng Luo, Qiuyue Cai, Zhangfang Li, Zhiyi Chen, Shidi Hu, Lei Tang
OBJECTIVE: Effective management of thyroid-associated ophthalmopathy (TAO) requires precise identification of the disease activity period as it is responsive to immunosuppressive treatment. Quantitative evaluations of orbital soft tissue is useful for analysing disease stages. We aimed to establish a method for orbital soft tissue volume calculation based on MRI data using 3D reconstruction technology. Further, we validated the accuracy and precision of this method and investigated volume differences between patients with TAO and healthy individuals...
February 7, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29396245/combined-immunosuppression-and-radiotherapy-in-thyroid-eye-disease-cirted-a-multicentre-2-%C3%A3-2-factorial-double-blind-randomised-controlled-trial
#8
Rathie Rajendram, Peter N Taylor, Victoria J Wilson, Nicola Harris, Olivia C Morris, Marjorie Tomlinson, Sue Yarrow, Helen Garrott, Helen M Herbert, Andrew D Dick, Anne Cook, Rao Gattamaneni, Rajni Jain, Jane Olver, Steven J Hurel, Fion Bremner, Suzannah R Drummond, Ewan Kemp, Diana M Ritchie, Nichola Rumsey, Daniel Morris, Carol Lane, Nachi Palaniappan, Chunhei Li, Julie Pell, Robert Hills, Daniel G Ezra, Mike J Potts, Sue Jackson, Geoffrey E Rose, Nicholas Plowman, Catey Bunce, Jimmy M Uddin, Richard W J Lee, Colin M Dayan
BACKGROUND: Standard treatment for thyroid eye disease is with systemic corticosteroids. We aimed to establish whether orbital radiotherapy or antiproliferative immunosuppression would confer any additional benefit. METHODS: CIRTED was a multicentre, double-blind, randomised controlled trial with a 2 × 2 factorial design done at six centres in the UK. Adults with active moderate-to-severe thyroid eye disease associated with proptosis or ocular motility restriction were recruited to the trial...
April 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29273685/igf-i-receptor-and-thyroid-associated-ophthalmopathy
#9
Michelle Mohyi, Terry J Smith
Thyroid-associated ophthalmopathy (TAO) is a vexing and poorly understood autoimmune process involving the upper face and tissues surrounding the eyes. In TAO, the orbit can become inflamed and undergo substantial remodeling that is disfiguring and can lead to loss of vision. These are currently no approved medical therapies for TAO, the consequence of its uncertain pathogenic nature. It usually presents as a component of the syndrome known as Graves' disease where loss of immune tolerance to the thyrotropin receptor (TSHR) results in the generation of activating antibodies against that protein and hyperthyroidism...
December 22, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29248534/new-antibody-based-therapies-for-thyroid-associated-ophthalmopathy
#10
Lilly H Wagner, Stuart R Seiff
No abstract text is available yet for this article.
December 15, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29235518/the-efficacy-of-intensity-modulated-radiation-therapy-in-treating-thyroid-associated-ophthalmopathy-and-predictive-factors-for-treatment-response
#11
Yong-Jiang Li, Yong Luo, Xiao-Qi Xie, Wei-Min He, Cheng Yi, Ping Li, Feng Wang
The study evaluated clinical efficacy of intensity modulated radiation therapy (IMRT) in treating patients with thyroid-associated ophthalmopathy (TAO) and defined predictive factors that associated with treatment response. A total of 178 TAO patients were treated with retro-orbital IMRT with radiation dose of 20 Gy in 10 fractions. The immediate and long-term treatment response and complications were evaluated. Besides, logistic-regression analysis was conducted to identify possible predictive factors. TAO symptom score significantly fell from the initiation to 6-month post-treatment (P < 0...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203853/quantitative-analysis-of-inflammation-in-orbital-fat-of-thyroid-associated-ophthalmopathy-using-mri-signal-intensity
#12
Tomoaki Higashiyama, Maki Iwasa, Masahito Ohji
We quantitatively analyzed inflammation in orbital fat from cases of thyroid-associated ophthalmopathy (TAO) using short-tau inversion recovery (STIR) sequences from magnetic resonance imaging. The signal intensity ratios (SIRs) of orbital fat as well as the superior rectus (SR), inferior rectus (IR), lateral rectus (LR), medial rectus (MR), and superior oblique (SO) muscles on STIR images were measured in 70 eyes from 70 treatment-naive TAO patients (active TAO group, 19 patients; inactive TAO group, 51 patients) and 20 eyes from 20 controls...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29184810/ophthalmic-manifestations-of-endocrine-disorders-endocrinology-and-the-eye
#13
REVIEW
Alisha Kamboj, Michael Lause, Priyanka Kumar
Disorders of the endocrine system usually manifest in a multi-organ fashion. More specifically, many endocrinopathies become apparent in the eye first through a variety of distinct pathophysiologic disturbances. The eye provides physicians with valuable clues for the recognition and management of numerous systemic diseases, including many disorders of the endocrine pathway. Recognizing ophthalmic manifestations of endocrine disorders is critical not only for rapid diagnosis and treatment, but also to prevent significant morbidity and mortality...
October 2017: Translational pediatrics
https://www.readbyqxmd.com/read/29130665/-effects-and-its-mechanism-of-igf-1r-on-the-synthesis-of-hyaluronic-acid-in-orbital-fibroblasts-of-thyroid-associated-ophthalmopathy
#14
Xiao-Ling Chen, Wei-Min He, Wei Li
OBJECTIVE: To explore the effects of insulin-like growth factor1 (IGF1) receptor (IGF1R) on the synthesis of hyaluronic acid (HA) in orbital fibroblasts of thyroid associated ophthalmopathy (TAO) and its signal pathway. METHODS: Orbital fibroblasts were harvested from TAO ( n=19) and normal control ( n=5),then were primary cultured and treated with recombinant human IGF1 in different concentrations. Before the treatment of IGF1,the cells were pretreated respectively with 1H7,LY294002 or AKT inhibitor Ⅳ for 24 h...
September 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29093229/the-role-of-cytotoxic-t-lymphocyte-associated-protein-4-ctla-4-gene-thyroid-stimulating-hormone-receptor-tshr-gene-and-regulatory-t-cells-as-risk-factors-for-relapse-in-patients-with-graves-disease
#15
Fatimah Eliana, Pradana Suwondo, Asmarinah Asmarinah, Alida Harahap, Samsuridjal Djauzi, Joedo Prihartono, Tjokorda Gde Dalem Pemayun
BACKGROUND: graves' disease (GD) is the most common condition of thyrotoxicosis. The management of GD is initiated with the administration of antithyroid drugs; however, it requires a long time to achieve remission. In reality more than 50% of patients who had remission may be at risk for relapse after the drug is stopped. This study aimed to evaluate the role of clinical factors such as smoking habit, degree of ophtalmopathy, degree of thyroid enlargement; genetic factors such as CTLA-4 gene on nucleotide 49 at codon 17 of exon 1, CTLA-4 gene of promotor -318, TSHR gene polymorphism rs2268458 of intron 1; and immunological factors such as regulatory T cells (Treg) and thyroid receptor antibody (TRAb); that affecting the relapse of patients with Graves' disease in Indonesia...
July 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29047240/identification-and-functional-characterization-of-st3gal5-and-st8sia1-variants-in-patients-with-thyroid-associated-ophthalmopathy
#16
Hyo Jin Park, Ju Hee Kim, Jin Sook Yoon, Yang Ji Choi, Yoon Hee Choi, Koung Hoon Kook, Ji Ha Choi
PURPOSE: This study was conducted to identify and to functionally characterize genetic variants in ST3GAL5 and ST8SIA1 in Korean patients with thyroid-associated ophthalmopathy (TAO). MATERIALS AND METHODS: Genetic analyses were conducted using DNA samples from TAO patients (n=50) and healthy subjects (n=48) to identify TAO-specific genetic variants of ST3GAL5 or ST8SIA1. The effect of each genetic variant on the transcription or expression of these genes was examined...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28951370/-a-novel-method-for-quantitative-measurement-of-orbital-fat-volume-based-on-magnetic-resonance-images
#17
Qiu-Yue Cai, Zhi-Yi Chen, Wei Jiang, Yao-Sheng Luo, Zhang-Fang Li, Shi-di Hu, Jie Shen
OBJECTIVE: To establish a new method for rapid and quantitative measurement of orbital fat volume based on magnetic resonance imaging (MRI) data. METHODS: We collected MRI data from normalized mold and patients with the diagnosis of thyroid-associated ophthalmopathy (TAO). The cross-sectional areas of the orbital fat on each MR image slice were measured to calculate the fat volume on each slice and then the total orbital fat volume. We recorded the time for completing the measurement and assessed the precision, reliability, repeatability and interoperator variations of the results...
September 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28919585/association-of-human-leukocyte-antigens-class-i-and-ii-with-graves-disease-in-iranian-population
#18
Zahra Mehraji, Ali Farazmand, Alireza Esteghamati, Sina Noshad, Maryam Sadr, Somayeh Amirzargar, Mir Saeed Yekaninejad, Aliakbar Amirzargar
BACKGROUND: Graves' disease (GD), a highly rampant autoimmune disorder of the thyroid gland, is responsible for 60-80% of the clinical cases of hyperthyroidism. Over the past decades, genetic association studies have identified several GD susceptibility loci in CTLA-4, TSHR and major histocompatibility complex regions. The information on the association between the human leukocyte antigens (HLA) and GD among Iranians is scarce. OBJECTIVE: To identify HLA polymorphisms that might confer susceptibility or protect against GD...
September 2017: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/28912808/association-of-polymorphisms-in-toll-like-receptors-4-and-9-with-autoimmune-thyroid-disease-in-korean-pediatric-patients
#19
Won Kyoung Cho, Jung-Pil Jang, Eun-Jeong Choi, Moonbae Ahn, Shin Hee Kim, Kyoung Soon Cho, So Hyun Park, In Cheol Baek, Min Ho Jung, Tai-Gyu Kim, Byung-Kyu Suh
BACKGROUND: Toll-like receptors (TLRs) have been suggested to be associated with the development of AITD. METHODS: Fifteen single-nucleotide polymorphisms in 7 TLR genes were analyzed in 104 Korean children (girls = 86, boys = 18) with AITD (Hashimoto disease (HD) = 44, Graves' disease (GD) = 60, thyroid-associated ophthalmopathy (TAO) = 29, and non-TAO = 31) with 183 controls. RESULTS: GD showed higher frequencies of the TLR4 rs1927911 C allele than control...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28878841/thyroid-association-ophthalmopathy-in-hashimoto-s-thyroiditis-a-case-report
#20
Deepak Jain, Sudhir Mor, Hari Krishan Aggarwal, Pulkit Chhabra, Promil Jain
Thyroid associated ophthalmopathy is a constellation of symptoms caused by an autoimmune process involving the orbital tissue. It is common in hyperthyroid patients due to Graves' disease and also reported in euthyroid and hypothyroid Graves' patients with positive thyroid receptor antibodies. But in Hashimoto's thyroiditis, thyroid associated ophthalmopathy is a rarely reported and poorly understood entity. Here we report thyroid associated ophthalmopathy in a patient with hypothyroidism and negative thyroid receptor antibodies who showed heterogeneously hypoechoic thyroid gland on ultrasonography, diffuse lymphocytic infiltrate on fine needle aspiration citology and reduced 99m Tc radioisotope uptake, supporting the diagnosis of Hashimoto's thyroiditis...
January 2017: Mædica
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