keyword
MENU ▼
Read by QxMD icon Read
search

thyroid associated ophthalmopathy

keyword
https://www.readbyqxmd.com/read/29915201/comparative-assessment-of-graves-disease-and-main-extrathyroidal-manifestation-graves-ophthalmopathy-by-non-targeted-metabolite-profiling-of-blood-and-orbital-tissue
#1
Dong Yoon Ji, Se Hee Park, Soo Jin Park, Kyoung Heon Kim, Cheol Ryong Ku, Dong Yeob Shin, Jin Sook Yoon, Do Yup Lee, Eun Jig Lee
Graves' disease (GD) is an autoimmune disorder that causes the overproduction of thyroid hormones and consequent cascade of systemic metabolism dysfunction. Moreover, Graves' ophthalmopathy (GO) is the main extrathyroidal manifestation of Graves' disease (GD). The goal of the study was to identify metabolic signatures in association with diagnostic biomarkers of GD without GO and GO, respectively. Ninety metabolites were profiled and analyzed based on a non-targeted primary metabolite profiling from plasma samples of 21 GD patients without GO, 26 subjects with GO, and 32 healthy subjects...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29890310/association-of-foxp3-promoter-polymorphisms-with-the-risk-of-graves-disease-in-ethnic-kashmiri-population
#2
Faheem Shehjar, Dil Afroze, Raiz A Misgar, Sajad A Malik, Bashir A Laway
Graves' disease is a multifactorial autoimmune disorder of the thyroid gland, with some extra-thyroidal complications like eye and skin abnormalities in some patients. GD is more prevalent in women than men and is the leading cause of hyperthyroidism worldwide. A complex interaction between genetic and environmental factors is the proposed cause which triggers immune system to produce autoantibodies stimulating the TSH receptor, leading to clinical manifestations such as hyperthyroidism, diffuse thyroid enlargement (goiter) and often ophthalmopathy in affected individuals...
June 8, 2018: Gene
https://www.readbyqxmd.com/read/29847668/cd34-orbital-fibroblasts-from-patients-with-thyroid-associated-ophthalmopathy-modulate-tnf-%C3%AE-expression-in-cd34-fibroblasts-and-fibrocytes
#3
Yan Lu, Stephen J Atkins, Roshini Fernando, Aaron Trierweiler, Tünde Mester, Ana Beatriz Diniz Grisolia, Pei Mou, Priscila Novaes, Terry J Smith
Purpose: Orbital fibroblasts from patients with Graves' disease (GD-OF) express many different cytokines when treated with bovine thyrotropin (bTSH). The present study aimed to determine why TNF-α cannot be induced by bTSH in GD-OF. Methods: Fibrocytes and GD-OFs were cultivated from donors who were patients in a busy academic medical center practice. Real-time PCR, Western blot analysis, reporter gene assays, cell transfections, mRNA stability assays, ELISA, and flow cytometry were performed...
May 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29804628/semi-automatic-volume-measurement-for-orbital-fat-and-total-extraocular-muscles-based-on-cube-fse-flex-sequence-in-patients-with-thyroid-associated-ophthalmopathy
#4
X Tang, H Liu, L Chen, Q Wang, B Luo, N Xiang, Y He, W Zhu, J Zhang
AIM: To investigate the accuracy of two semi-automatic segmentation measurements based on magnetic resonance imaging (MRI) three-dimensional (3D) Cube fast spin echo (FSE)-flex sequence in phantoms, and to evaluate the feasibility of determining the volumetric alterations of orbital fat (OF) and total extraocular muscles (TEM) in patients with thyroid-associated ophthalmopathy (TAO) by semi-automatic segmentation. MATERIALS AND METHODS: Forty-four fatty (n=22) and lean (n=22) phantoms were scanned by using Cube FSE-flex sequence with a 3 T MRI system...
May 24, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29774886/-evaluation-of-inflammatory-activity-in-thyroid-associated-ophthalmopathy-by-spect-ct-with-99mtc-dtpa
#5
Dan Liu, Xueliang Xu, Dan Wen, Jia Tan, Chengzhi Jiang
To evaluate the inflammatory activity in thyroid associated ophthalmopathy (TAO) by 99mTc-diethylene triamine pentaaceticacid (99mTc-DTPA) orbital single-photon emission computed tomography (SPECT)/CT.
 Methods: A total of 48 patients were enrolled from Xiangya Hospital of Central South University between October 2016 and March 2017. According to clinical active score (CAS), 93 eyes were divided into a TAO active group (n=72) and a TAO inactive group (n=21). All patients underwent 99mTc-DTPA orbital SPECT/CT examination, and the DTPA uptake in extraocular muscle belly was supposed to be positive...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29771881/-prediction-of-activity-and-severity-of-endocrine-ophthalmopathy-by-multidimensional-linear-regression-modeling
#6
V G Lihvantseva, M S Afanasev, E A Rudenko, A V Karaulov, S S Afanasev, E V Korosteleva, V A Vygodin
Endocrine ophthalmopathy (EOP) is a severe chronic autoimmune disease associated with autoimmune thyroid pathology that leads to loss of sight, cosmetic defects and quality of life decrease. EOP is difficult to give prognosis for due to various factors affecting its course and outcome. PURPOSE: To develop a reliable and precise prognosis method for EOP activity and severity based on personalized combination of risk factors in specific patients by multidimensional linear regression modeling...
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29752312/slit2-modulates-the-inflammatory-phenotype-of-orbit-infiltrating-fibrocytes-in-graves-disease
#7
Roshini Fernando, Ana Beatriz Diniz Grisolia, Yan Lu, Stephen Atkins, Terry J Smith
Human CD34+ fibrocytes, circulating monocyte lineage progenitor cells, have recently been implicated in thyroid-associated ophthalmopathy (TAO), the ocular manifestation of Graves' disease (GD). Fibrocytes express constitutive MHC class II (MHC-2) and, surprisingly, thyroglobulin (Tg) and functional thyrotropin (TSH) receptor (TSHR). Underlying expression of these thyroid proteins is the autoimmune regulator protein (AIRE). Fibrocytes respond robustly to TSH and thyroid-stimulating Igs by generating extremely high levels of inflammatory cytokines, such as IL-6...
May 11, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29744034/new-advances-in-understanding-thyroid-associated-ophthalmopathy-and-the-potential-role-for-insulin-like-growth-factor-i-receptor
#8
REVIEW
Terry J Smith
Thyroid-associated ophthalmopathy (TAO), a localized periocular manifestation of the autoimmune syndrome known as Graves' disease, remains incompletely understood. Discussions of its pathogenesis are generally focused on the thyrotropin receptor, the proposed role for which is supported by substantial evidence. Considerations of any involvement of the insulin-like growth factor-I receptor (IGF-IR) in the disease are frequently contentious. In this brief, topically focused review, I have attempted to provide a balanced perspective based entirely on experimental results that either favor or refute involvement of IGF-IR in TAO...
2018: F1000Research
https://www.readbyqxmd.com/read/29742012/simultaneous-ipsilateral-transconjunctival-repair-of-upper-and-lower-eyelid-retraction-in-thyroid-associated-ophthalmopathy
#9
Nahyoung Grace Lee, Larissa Habib, Jonathan Hall, Suzanne K Freitag
PURPOSE: To report a simple, highly effective technique of simultaneous transconjunctival repair of upper and lower eyelid retraction in patients with thyroid eye disease (TED). METHODS: A retrospective interventional case review was conducted on 22 eyes of 19 TED patients. The lower eyelid was recessed with placement of a tarsoconjunctival spacer graft harvested from the upper eyelid. The upper eyelid was then recessed through the conjunctival incision used to harvest the tarsal graft...
May 9, 2018: Orbit
https://www.readbyqxmd.com/read/29732037/prevalence-and-severity-of-ocular-involvement-in-graves-disease-according-to-sex-and-age-a-clinical-study-from-babol-iran
#10
Sara Gharib, Zoleika Moazezi, Mohammad Ali Bayani
Background: Thyroid-associated eye disease (TED), previously known as Graves' ophthalmopathy is a cosmetically and functionally debilitating disease that is seen worldwide. The aim of this study was to evaluate the prevalence and clinical severity of ocular manifestations of Graves' disease according to sex, age and duration in northern Iran. Methods: Between April 2011 and March 2012, 105 patients with Graves' disease, underwent ophthalmic examination, including ocular motility, exophthalmometry, intraocular pressure (IOP), slit lamp and fundoscopy...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29719374/clinical-course-of-thyroid-function-and-thyroid-associated-ophthalmopathy-in-patients-with-euthyroid-graves-disease
#11
Nami Suzuki, Jaeduk Yoshimura Noh, Toshiaki Kameda, Ai Yoshihara, Hidemi Ohye, Miho Suzuki, Masako Matsumoto, Yo Kunii, Kenji Iwaku, Natsuko Watanabe, Koji Mukasa, Ai Kozaki, Toshu Inoue, Kiminori Sugino, Koichi Ito
Background: Euthyroid Graves' disease (EGD) is a rare condition defined as the presence of thyroid-associated ophthalmopathy (TAO) in patients with normal thyroid function. Due to the rarity of this disease, only a limited number of studies and case reports are available for further evaluation of the characteristics of the disease. The aim of this study was to examine the changes in the thyroid function, thyrotropin receptor antibodies (TRAb) and eye symptoms, and then determine whether TRAb is related to TAO in EGD patients...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29703002/embolic-retinal-and-choroidal-vascular-occlusion-after-peribulbar-triamcinolone-injection-a-case-report
#12
Gang Li, Dongdong Xu, Zhirou Hu, Hui Li
RATIONALE: Retinal and choroidal vascular occlusion is a vision-threatening complication of therapeutic injections in the facial region. The early identification and early treatment are necessary to reduce the risk of harm to the patient. PATIENT CONCERNS: We report an extremely rare case of embolic retinal and choroidal vascular occlusion after peribulbar triamcinolone injection in a patient with thyroid-associated ophthalmopathy. DIAGNOSES: Central retinal artery occlusion...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29675428/ptx3-a-potential-biomarker-in-thyroid-associated-ophthalmopathy
#13
Pei Mou, Ziyu Chen, Lihong Jiang, Jinwei Cheng, Ruili Wei
Background: Thyroid associated ophthalmopathy (TAO) is an autoimmune disease, which involves inflammation and tissue remodeling. Pentraxin-3 (PTX3) is a component of innate immune system and recently implicated in autoimmunity. This observation may indicate that PTX3 participates in the inflammatory process of TAO. Methods: All studies were performed on TAO patients and healthy controls (45: 28 in total). RNA-seq was used to detect differential gene expression of orbital adipose-connective tissue...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29643678/metabolic-bone-superscan-in-carcinoma-breast-with-occult-graves-disease-looking-beyond-skeletal-metastases
#14
Ashwin Singh Parihar, Ashwani Sood, Tinu Thadiyananickal Lukose, Rajeev Kumar Seam, Bhagwant Rai Mittal
Extrathyroidal manifestations of autoimmune thyroid disorders include thyroid-associated ophthalmopathy, thyroid dermopathy, and thyroid acropachy. Thyroid acropachy is an extreme manifestation of autoimmune thyroid disorder characterized by clubbing and swelling of fingers and toes, with or without periosteal reaction of the distal bones. We present a 50-year-old woman, posttreatment for carcinoma breast (6 years back) and referred for bone scan for generalized body ache. Bone scan findings resulting in detailed clinical evaluation prompted toward the suspicion of a thyroidal disease with ultimate diagnosis of Graves' disease...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29546054/serum-trace-elements-profile-in-graves-disease-patients-with-or-without-orbitopathy-in-northeast-china
#15
Yongping Liu, Shanshan Liu, Jinyuan Mao, Sichen Piao, Jing Qin, Shiqiao Peng, Xiaochen Xie, Haixia Guan, Yushu Li, Zhongyan Shan, Weiping Teng
Objective: The purpose of the present study was to investigate serum trace elements in Graves' disease (GD) patients with or without orbitopathy in Northeast China. Methods: Patients with newly diagnosed Graves' disease (HyGD) ( n = 66), GD patients with euthyroid status or subclinical thyroidism after treatment (EUGD) ( n = 55), GO patients with euthyroid status or subclinical thyroidism after treatment (GO) ( n = 57), and normal controls (NC) ( n = 66) were enrolled in this study...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29521049/elevated-serum-concentrations-of-metalloproteinases-mmp-2-mmp-9-and-their-inhibitors-timp-1-timp-2-in-patients-with-graves-orbitopathy
#16
Katarzyna Kapelko-Słowik, Mirosław Słowik, Marek Szaliński, Jarosław Dybko, Dariusz Wołowiec, Iwona Prajs, Anna Bohdanowicz-Pawlak, Monika Biernat, Donata Urbaniak-Kujda
BACKGROUND: Graves' orbitopathy (GO), also known as thyroid-associated ophthalmopathy, is characterized by dramatic tissue reactivity. Both inflammation and tissue remodeling characterize the clinical course of GO. Some data has been found regarding the association of MMPs and TIMPs in GO. MATERIAL AND METHODS: Serum concentrations of MMP-9, MMP-2, TIMP-1, and TIMP-2 were determined by ELISA method. OBJECTIVES: Forty-eight patients (34 females, 14 males, with median age 51...
January 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29463244/a-single-center-retrospective-study-of-factors-related-to-the-effects-of-intravenous-glucocorticoid-therapy-in-moderate-to-severe-and-active-thyroid-associated-ophthalmopathy
#17
Yang Wang, Shuo Zhang, Yidan Zhang, Xingtong Liu, Hao Gu, Sisi Zhong, Yazhuo Huang, Sijie Fang, Jing Sun, Huifang Zhou, Xianqun Fan
BACKGROUND: Intravenous glucocorticoids (ivGC) have been recommended as a first-line treatment of moderate-to-severe and active thyroid-associated ophthalmopathy (TAO). However, not all patients are responsive to ivGC. The identification of potential factors used to predict their efficacy and the selection of suitable patients have both been lacking. METHODS: It was a single center retrospective study. Potential factors related to the effects of ivGC were analyzed using logistic regression in 90 consecutive patients with moderate-to-severe and active TAO, who received 4...
February 20, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29452583/does-rituximab-improve-clinical-outcomes-of-patients-with-thyroid-associated-ophthalmopathy-a-systematic-review-and-meta-analysis
#18
REVIEW
Changjun Wang, Qingyao Ning, Kai Jin, Jiajun Xie, Juan Ye
BACKGROUND: The current therapies of thyroid-associated ophthalmopathy (TAO) were still a challenging matter. In this study, we aimed to contrast the impact of before- after rituximab (RTX) therapy in the patients with TAO. METHODS: We searched the PubMed, EMBASE, and SCOPUS databases for articles published up to July 3, 2017. Fixed- or random-effects meta-analysis was used to provide pooled estimates of standard mean difference (SMD) both the primary outcome from clinical activity score (CAS), and secondary outcomes from thyrotropin receptor antibody (TRAb), proptosis, thyroid stimulating hormone (TSH), and interleukin-6 (IL-6) levels...
February 17, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29412482/establishment-of-magnetic-resonance-imaging-3d-reconstruction-technology-of-orbital-soft-tissue-and-its-preliminary-application-in-patients-with-thyroid-associated-ophthalmopathy
#19
Jie Shen, Wei Jiang, Yaosheng Luo, Qiuyue Cai, Zhangfang Li, Zhiyi Chen, Shidi Hu, Lei Tang
OBJECTIVE: Effective management of thyroid-associated ophthalmopathy (TAO) requires precise identification of the disease activity period as it is responsive to immunosuppressive treatment. Quantitative evaluations of orbital soft tissue are useful for analysing disease stages. We aimed to establish a method for orbital soft tissue volume calculation based on magnetic resonance imaging (MRI) data using 3D reconstruction technology. Furthermore, we validated the accuracy and precision of this method and investigated volume differences between patients with TAO and healthy individuals...
May 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29396245/combined-immunosuppression-and-radiotherapy-in-thyroid-eye-disease-cirted-a-multicentre-2-%C3%A3-2-factorial-double-blind-randomised-controlled-trial
#20
Rathie Rajendram, Peter N Taylor, Victoria J Wilson, Nicola Harris, Olivia C Morris, Marjorie Tomlinson, Sue Yarrow, Helen Garrott, Helen M Herbert, Andrew D Dick, Anne Cook, Rao Gattamaneni, Rajni Jain, Jane Olver, Steven J Hurel, Fion Bremner, Suzannah R Drummond, Ewan Kemp, Diana M Ritchie, Nichola Rumsey, Daniel Morris, Carol Lane, Nachi Palaniappan, Chunhei Li, Julie Pell, Robert Hills, Daniel G Ezra, Mike J Potts, Sue Jackson, Geoffrey E Rose, Nicholas Plowman, Catey Bunce, Jimmy M Uddin, Richard W J Lee, Colin M Dayan
BACKGROUND: Standard treatment for thyroid eye disease is with systemic corticosteroids. We aimed to establish whether orbital radiotherapy or antiproliferative immunosuppression would confer any additional benefit. METHODS: CIRTED was a multicentre, double-blind, randomised controlled trial with a 2 × 2 factorial design done at six centres in the UK. Adults with active moderate-to-severe thyroid eye disease associated with proptosis or ocular motility restriction were recruited to the trial...
April 2018: Lancet Diabetes & Endocrinology
keyword
keyword
43756
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"