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https://www.readbyqxmd.com/read/27933543/integrative-analysis-of-genetic-genomic-and-phenotypic-data-for-ethanol-behaviors-a-network-based-pipeline-for-identifying-mechanisms-and-potential-drug-targets
#1
James W Bogenpohl, Kristin M Mignogna, Maren L Smith, Michael F Miles
Complex behavioral traits, such as alcohol abuse, are caused by an interplay of genetic and environmental factors, producing deleterious functional adaptations in the central nervous system. The long-term behavioral consequences of such changes are of substantial cost to both the individual and society. Substantial progress has been made in the last two decades in understanding elements of brain mechanisms underlying responses to ethanol in animal models and risk factors for alcohol use disorder (AUD) in humans...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27933066/functionally-diverse-nk-like-t-cells-are-effectors-and-predictors-of-successful-aging
#2
REVIEW
Joshua J Michel, Patricia Griffin, Abbe N Vallejo
The fundamental challenge of aging and long-term survivorship is maintenance of functional independence and compression of morbidity despite a life history of disease. Inasmuch as immunity is a determinant of individual health and fitness, unraveling novel mechanisms of immune homeostasis in late life is of paramount interest. Comparative studies of young and old persons have documented age-related atrophy of the thymus, the contraction of diversity of the T cell receptor (TCR) repertoire, and the intrinsic inefficiency of classical TCR signaling in aged T cells...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27933044/antibiotic-resistance-in-the-food-chain-a-developing-country-perspective
#3
REVIEW
Luria Leslie Founou, Raspail Carrel Founou, Sabiha Yusuf Essack
Antibiotics are now "endangered species" facing extinction due to the worldwide emergence of antibiotic resistance (ABR). Food animals are considered as key reservoirs of antibiotic-resistant bacteria with the use of antibiotics in the food production industry having contributed to the actual global challenge of ABR. There are no geographic boundaries to impede the worldwide spread of ABR. If preventive and containment measures are not applied locally, nationally and regionally, the limited interventions in one country, continent and for instance, in the developing world, could compromise the efficacy and endanger ABR containment policies implemented in other parts of the world, the best-managed high-resource countries included...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27932546/what-can-a-participatory-approach-to-evaluation-contribute-to-the-field-of-integrated-care
#4
Laura Eyre, Michael Farrelly, Martin Marshall
Better integration of care within the health sector and between health and social care is seen in many countries as an essential way of addressing the enduring problems of dwindling resources, changing demographics and unacceptable variation in quality of care. Current research evidence about the effectiveness of integration efforts supports neither the enthusiasm of those promoting and designing integrated care programmes nor the growing efforts of practitioners attempting to integrate care on the ground. In this paper we present a methodological approach, based on the principles of participatory research, that attempts to address this challenge...
December 8, 2016: BMJ Quality & Safety
https://www.readbyqxmd.com/read/27932367/changing-the-way-we-view-and-talk-about-frailty%C3%A2
#5
Caroline Nicholson, Adam Lee Gordon, Anthea Tinker
This commentary discusses the perception of frailty by different key stakeholders-most notably older people. It considers the need to integrate predominantly medically driven understandings of frailty within a wider conceptual framework. This is imperative if the potential of frailty as a construct, around which the optimisation of health and well-being of older people can take place, is to be realised.
December 7, 2016: Age and Ageing
https://www.readbyqxmd.com/read/27932338/meaning-of-living-with-severe-chronic-obstructive-lung-disease-a-qualitative-study
#6
Gabriella Marx, Maximilian Nasse, Henrikje Stanze, Sonja Owusu Boakye, Friedemann Nauck, Nils Schneider
OBJECTIVES: To explore what it means for patients to live with chronic obstructive pulmonary disease (COPD) as an incurable and constantly progressing disease. DESIGN: Qualitative longitudinal study using narrative and semistructured interviews. This paper presents findings of the initial interviews. Analysis using grounded theory. SETTING: Lung care clinics and community care in Lower Saxony, Germany. PARTICIPANTS: 17 patients with advanced-stage COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) III/IV)...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27932262/the-coach-program-a-joint-approach-to-patient-education-and-support
#7
Yael Shaked, Patricia Dickson, Kathy Workman
Hospital lengths of stay for orthopaedic procedures are declining internationally. Discharge home from hospital following total joint replacement surgery can be stressful due to pain and physical restrictions. Thus, many patients report experiencing increased anxiety and feeling a sudden withdrawal of support from their medical team. The Coach Program maximizes human resources and family-centred care by formally integrating an individual whom the patient identifies as their primary support into their health care team...
December 5, 2016: Healthcare
https://www.readbyqxmd.com/read/27932261/does-adding-clinical-data-to-administrative-data-improve-agreement-among-hospital-quality-measures
#8
Amresh D Hanchate, Kelly L Stolzmann, Amy K Rosen, Aaron S Fink, Michael Shwartz, Arlene S Ash, Hassen Abdulkerim, Mary Jo V Pugh, Priti Shokeen, Ann Borzecki
BACKGROUND: Hospital performance measures based on patient mortality and readmission have indicated modest rates of agreement. We examined if combining clinical data on laboratory tests and vital signs with administrative data leads to improved agreement with each other, and with other measures of hospital performance in the nation's largest integrated health care system. METHODS: We used patient-level administrative and clinical data, and hospital-level data on quality indicators, for 2007-2010 from the Veterans Health Administration (VA)...
December 5, 2016: Healthcare
https://www.readbyqxmd.com/read/27932216/arsenic-contamination-of-drinking-water-in-ireland-a-spatial-analysis-of-occurrence-and-potential-risk
#9
Ellen R McGrory, Colin Brown, Norma Bargary, Natalya Hunter Williams, Anthony Mannix, Chaosheng Zhang, Tiernan Henry, Eve Daly, Sarah Nicholas, Barbara M Petrunic, Monica Lee, Liam Morrison
The presence of arsenic in groundwater has become a global concern due to the health risks from drinking water with elevated concentrations. The Water Framework Directive (WFD) of the European Union calls for drinking water risk assessment for member states. The present study amalgamates readily available national and sub-national scale datasets on arsenic in groundwater in the Republic of Ireland. However, due to the presence of high levels of left censoring (i.e. arsenic values below an analytical detection limit) and changes in detection limits over time, the application of conventional statistical methods would inhibit the generation of meaningful results...
December 5, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27931992/the-attitudes-of-primary-healthcare-providers-towards-web-based-training-on-public-health-services-in-rural-china-a-cross-sectional-study
#10
X X Zhan, Z X Zhang, F Sun, W J Peng, H Zhang, W R Yan
OBJECTIVES: To explore the attitudes of primary healthcare workers, including township public health workers (TPHWs) and village doctors (ViDs), towards web-based training on basic public health services (BPHS) and to examine the factors influencing their attitudes. STUDY DESIGN: Cross-sectional study. METHODS: Questionnaires addressing training status, needs, and attitudes towards web-based public health training were administered to 2768 primary healthcare workers from May to September 2013...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931371/water-reclamation-and-reuse
#11
Chunkai Huang, Ping Zeng, Sen Yang, Yanxi Shao, Yang Liu
A review of the literature published in 2015 on topics relating to water reclamation and reuse is presented. The review is divided into the following sections: (1) General: extent of reuse, research needs, guidelines and monitoring, health effects; (2) Treatment technologies: integrated process design, membrane treatment, membrane bioreactors, electrocoagulation, ion exchange and adsorption, disinfection, wetlands, managed aquifer recharge; (3) Planning and management: public acceptance and education, economics/pricing, water quality planning and management and project/case studies...
October 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/27931314/developing-a-performance-standard-for-adequate-sanitization-of-wire-bar-lids
#12
Linna E Srn, Louise K Hammarberg, Robin J Kastenmayer, Liselotte C Hallengren
The wire-bar lids on rodent cages are an integral part of the microenvironment and as such can impact rodent health and wellbeing. The Guide for the Care and Use of Laboratory Animals recommends changing wire-bar lids every other week but does not include a predetermined performance standard. To develop a sanitization performance standard, we evaluated the bacterial and other cellular burden of wire-bar lids over 4 wk. The results show no significant difference in ATP or bacterial burden over 3 wk of continuous use in conventional cages with standard rodent pelleted or high-fat diet or in IVC with an irradiated diet...
November 2016: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/27930963/-teaching-on-the-run-with-australian-midwives-in-a-tertiary-maternity-hospital
#13
Yvonne Hauck, Lucy Lewis, Alissa Pemberton, Caroline Crichton, Janice Butt
Teaching On The Run (TOTR) is an Australian program for health professionals involved in clinical supervision. An amended TOTR program was evaluated with midwives acting as preceptors assisting learners integrate theory with clinical practice. A mixed method study was employed to compare midwives' perceived skills and confidence before and after completion of TOTR workshops. A secondary aim explored midwifery learners' (students and new graduates) perceptions of support from preceptors during the implementation of TOTR...
November 25, 2016: Nurse Education in Practice
https://www.readbyqxmd.com/read/27930612/potential-impact-of-integrated-stigma-mitigation-interventions-in-improving-hiv-aids-service-delivery-and-uptake-for-key-populations-in-senegal
#14
Carrie E Lyons, Sosthenes Ketende, Daouda Diouf, Fatou M Drame, Benjamin Liestman, Karleen Coly, Cheikh Ndour, Gnilane Turpin, Souleymane Mboup, Karim Diop, Coumba Toure-Kane, Delivette Castor, Nafissatou Leye-Diouf, Stefan Baral
BACKGROUND: Men who have sex with men (MSM) and female sex workers (FSW) are consistently shown to have a higher burden of HIV compared with other adults in Senegal. This study, HIV Prevention 2.0, evaluates the impact of the 3-tiered integrated stigma mitigation interventions (ISMIs) approach to optimizing HIV service delivery for key populations in Senegal. METHODS: Baseline assessment includes a questionnaire and biological testing for HIV. A proportion of participants enrolled into a 24-month longitudinal cohort with questionnaires and biological testing every 3 months...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27930609/feasibility-and-acceptability-of-health-communication-interventions-within-a-combination-intervention-strategy-for-improving-linkage-and-retention-in-hiv-care-in-mozambique
#15
Roberta Sutton, Maria Lahuerta, Fatima Abacassamo, Laurence Ahoua, Maria Tomo, Matthew R Lamb, Batya Elul
BACKGROUND: Challenges to ensuring timely linkage to and retention in HIV care are well documented. Combination intervention strategies can be effective in improving the HIV care continuum. Data on feasibility and acceptability of intervention types within intervention packages are limited. METHODS: The Engage4Health study assessed the effectiveness of a combination intervention strategy to increase linkage and retention among adults newly diagnosed with HIV in Mozambique...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27930607/counseling-framework-for-hiv-serodiscordant-couples-on-the-integrated-use-of-antiretroviral-therapy-and-pre-exposure-prophylaxis-for-hiv-prevention
#16
Jennifer F Morton, Connie Celum, John Njoroge, Agnes Nakyanzi, Imeldah Wakhungu, Edna Tindimwebwa, Snaidah Ongachi, Eric Sedah, Emmanuel Okwero, Kenneth Ngure, Josephine Odoyo, Nulu Bulya, Jessica E Haberer, Jared M Baeten, Renee Heffron
BACKGROUND: For HIV-serodiscordant couples, integrated delivery of antiretroviral therapy (ART) for HIV-positive partners and time-limited pre-exposure prophylaxis (PrEP) for negative partners virtually eliminates HIV transmission. Standardized messaging, sensitive to the barriers and motivators to HIV treatment and prevention, is needed for widespread scale-up of this approach. METHODS: Within the Partners Demonstration Project, a prospective interventional project among 1013 serodiscordant couples in Kenya and Uganda, we offered ART to eligible HIV-positive partners and PrEP to HIV-negative partners before ART initiation and through the HIV-positive partner's first 6 months of ART use...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27930533/association-of-vagus-nerve-severance-and-decreased-risk-of-subsequent-type-2-diabetes-in-peptic-ulcer-patients-an-asian-population-cohort-study
#17
Shih-Chi Wu, William Tzu-Liang Chen, Chu-Wen Fang, Chih-Hsin Muo, Fung-Chang Sung, Chung Y Hsu
Vagus nerve may play a role in serum glucose modulation. The complicated peptic ulcer patients (with perforation or/and bleeding) who received surgical procedures with or without vagotomy provided 2 patient populations for studying the impact of vagus nerve integrity. We assessed the risk of developing type 2 diabetes in peptic ulcer patients without and with complications by surgical treatment received in a retrospective population study using the National Health Insurance database in Taiwan.A cohort of 163,385 patients with peptic ulcer and without Helicobacter pylori infection in 2000 to 2003 was established...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930473/association-between-exercise-frequency-and-health-care-costs-among-employees-at-a-large-university-and-academic-medical-center
#18
David C Caretto, Truls Ostbye, Marissa Stroo, Dennis J Darcey, John Dement
OBJECTIVE: The aim of this study was to evaluate the relationship between exercise frequency and health care costs associated with medical and pharmacy claims among a 10-year employee cohort. METHODS: The relationship between self-reported exercise (days/week) and health care costs was analyzed with negative binomial regression, using an integrated database involving 32,044 person-years and linking employee demographics, health risk appraisal information, and health insurance claims...
December 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27929690/comparison-of-the-center-for-epidemiology-studies-depression-scale-and-beck-depression-inventory-for-research-with-latinas
#19
Melinda Bogardus
U.S. Latino farmworkers face multiple potential stressors. Research on the mental health status of this U.S. Latino subgroup has suggested high prevalence of stress, anxiety, and depressive symptoms when compared to other groups. Latina farmworkers may be at greater risk than their male counterparts for poor mental health because they confront many of the same stressors but may experience additional difficulties including domestic violence, taking on new roles and responsibilities on top of traditional ones, and being expected to maintain the health and integrity of their families at the expense of their own needs...
December 8, 2016: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/27929687/meaning-in-life-and-meaning-of-life-in-mental-health-care-an-integrative-literature-review
#20
Xanthe Glaw, Ashley Kable, Michael Hazelton, Kerry Inder
The aim of this integrative literature review was to identify high quality empirical research and theoretical literature on the sources of meaning in life and people's beliefs regarding the meaning of life. This will inform current mental health clinical practice and research by providing a synthesis of empirical and theoretical literature. Failure to address meaninglessness or the existential crisis can lead to psychopathologies such as depression, anxiety, addiction, aggression, hopelessness, apathy, lower levels of well-being, physical illness, and suicide...
December 8, 2016: Issues in Mental Health Nursing
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