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Mineral corticoid receptor

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https://www.readbyqxmd.com/read/27301330/coexisting-hyponatremia-and-decline-in-diastolic-blood-pressure-predispose-to-atrial-standstill-in-hyperkalemic-patients
#1
Takeshi Ideguchi, Toshihiro Tsuruda, Yuji Sato, Kazuo Kitamura
BACKGROUND: Atrial standstill is one of the important clinical consequences on the heart in severe hyperkalemia, but it occurs even at modest potassium ion elevation. The extent to which other factors might potentiate the electrocardiographic changes induced by hyperkalemia remains unclear. METHODS AND RESULTS: This was a retrospective review of the data on 12,639 hospital admissions over a 15-year period. A total of 778 patients with hyperkalemia were identified, 28 of whom had atrial standstill, and had several parameters measured prior to any treatment of hyperkalemia...
July 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27170200/prognostic-impact-of-loop-diuretics-in-patients-with-chronic-heart-failure%C3%A3-effects-of-addition-of-renin-angiotensin-aldosterone-system-inhibitors-and-%C3%AE-blockers
#2
Masanobu Miura, Koichiro Sugimura, Yasuhiko Sakata, Satoshi Miyata, Soichiro Tadaki, Takeshi Yamauchi, Takeo Onose, Kanako Tsuji, Ruri Abe, Takuya Oikawa, Shintaro Kasahara, Kotaro Nochioka, Jun Takahashi, Hiroaki Shimokawa
BACKGROUND: It remains to be elucidated whether addition of renin-angiotensin-aldosterone system (RAAS) inhibitors and/or β-blockers to loop diuretics has a beneficial prognostic impact on chronic heart failure (CHF) patients. METHODS AND RESULTS: From the Chronic Heart failure Analysis and Registry in the Tohoku district 2 (CHART-2) Study (n=10,219), we enrolled 4,134 consecutive patients with symptomatic stage C/D CHF (mean age, 69.3 years, 67.7% male). We constructed Cox models for composite of death, myocardial infarction, stroke and HF admission...
May 25, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/25115697/role-of-renin-angiotensin-aldosterone-system-in-metabolic-syndrome-and-obesity-related-hypertension
#3
K Kamide
Several recent clinical trials show that blocking agents of the renin-angiotensin-aldosterone system (RAAS) reduce cardiovascular events in patients with metabolic syndrome based on insulin resistance and obesity, especially accumulated visceral fat. Our laboratory has focused on the relationship between the vascular RAAS and the action of insulin on the vasculature. We first revealed that the addition of insulin to cultured vascular smooth muscle cells (VSMC) markedly increases angiotensinogen and angiotensin II (Ang II) expression and production...
August 12, 2014: Current Hypertension Reviews
https://www.readbyqxmd.com/read/24882402/3-monoglucuronyl-glycyrrhretinic-acid-is-a-possible-marker-compound-related-to-licorice-induced-pseudoaldosteronism
#4
REVIEW
Toshiaki Makino
One of the most common adverse effects of traditional Japanese kampo and traditional Chinese medicine is pseudoaldosteronism caused by licorice. In this review, the authors describe the mechanisms of licorice-induced pseudoaldosteronism by the pharmacokinetics of chemical constituents and its metabolites containing licorice. Glycyrrhizin (GL), the main constituent of licorice, is absorbed as glycyrrhetinic acid (GA), which is a metabolite of GL produced by enterobacteria before its release into the circulation...
2014: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/24864461/-prognostic-value-of-detection-of-arterial-hypotensive-episodes-in-patients-with-chronic-heart-failure
#5
V A Serov, A M Shutov, D V Serova, E Iu Shmel'kova, S V Shevchenko
AIM: To define the prognostic value of arterial hypotension (AH) episodes in patients with chronic heart failure (CHF). SUBJECTS AND METHODS: One hundred and ninety-nine patients (mean age 57.2 +/- 10.5 years) were examined. Functional Class I, II, III, and IV CHF was diagnosed in 24, 92, 82, and 1 patients, respectively. The cause of CHF was coronary heart disease concurrent with hypertensive disease in 160 patients. AH was diagnosed when their blood pressure (BP) was < or = 100/60 mm Hg during medical visits and daytime BP < or = 100/60 mm Hg and nocturnal BP < or = 85/47 mm Hg were measured during 24-hour BP monitoring (BPM)...
2014: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/24405838/spironolactone-not-furosemide-improved-insulin-resistance-in-patients-with-chronic-heart-failure
#6
RANDOMIZED CONTROLLED TRIAL
Kazuhide Ogino, Yoshiharu Kinugasa, Masahiko Kato, Kazuhiro Yamamoto, Ichiro Hisatome, Stefan D Anker, Wolfram Doehner
BACKGROUND/OBJECTIVES: Insulin resistance plays an important role in the pathophysiology in chronic heart failure (CHF). Diuretics generally have harmful effects on glucose metabolism, however, the effect of mineral corticoid receptor blockers on insulin resistance in CHF is unclear. This study aimed to evaluate the effects of the aldosterone blocker spironolactone, in comparison with furosemide, on insulin resistance in CHF patients. METHODS: The effect of spironolactone (25mg/day) and furosemide (20mg/day) on IR for 16 weeks each was analyzed in 16 CHF patients using a double-blind, placebo-controlled, randomized cross-over study design...
February 15, 2014: International Journal of Cardiology
https://www.readbyqxmd.com/read/23995321/does-cirrhotic-cardiomyopathy-exist-50-years-of-uncertainty
#7
REVIEW
Pierpaolo Pellicori, Concetta Torromeo, Angela Calicchia, Alessandra Ruffa, Martina Di Iorio, John G F Cleland, Manuela Merli
Subtle abnormalities of cardiac structure or function are often identified in patients with liver cirrhosis and have been termed cirrhotic cardiomyopathy. However, in the absence of a precise definition, its diagnosis remains a challenge. Cardiac dysfunction in patients with cirrhosis can often be attributed to concomitant diseases such as hypertension, ischaemic heart disease or excess alcohol consumption in many patients. Further research is required to identify the existence, origin and importance of abnormal cardiac function due specifically to liver disease...
December 2013: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/22494929/meta-analysis-of-two-genome-wide-association-studies-identifies-four-genetic-loci-associated-with-thyroid-function
#8
Rajesh Rawal, Alexander Teumer, Henry Völzke, Henri Wallaschofski, Till Ittermann, Bjørn O Åsvold, Trine Bjøro, Karin H Greiser, Daniel Tiller, Karl Werdan, Henriette E Meyer zu Schwabedissen, Angela Doering, Thomas Illig, Christian Gieger, Christa Meisinger, Georg Homuth
Thyroid hormones play key roles in cellular growth, development and metabolism. Although there is a strong genetic influence on thyroid hormone levels, the genes involved are widely unknown. The levels of circulating thyroid hormones are tightly regulated by thyrotropin (TSH), which also represents the most important diagnostic marker for thyroid function. Therefore, in order to identify genetic loci associated with TSH levels, we performed a discovery meta-analysis of two genome-wide association studies including two cohorts from Germany, KORA (n = 1287) and SHIP (n = 2449), resulting in a total sample size of 3736...
July 15, 2012: Human Molecular Genetics
https://www.readbyqxmd.com/read/21695412/dexamethasone-increases-the-phosphorylation-of-nephrin-in-cultured-podocytes
#9
Teiko Ohashi, Keiko Uchida, Shinichi Uchida, Sei Sasaki, Kosaku Nitta
BACKGROUND: We reported that nephrin is phosphorylated at Y1204 and Y1228 under normal conditions and that the phosphorylation is decreased in puromycin nephrosis and in human minimal change nephrosis. These results indicate that the phosphorylation of nephrin is important for maintaining normal podocyte function. However, little is known about the regulation of nephrin phosphorylation. Here, we investigated whether glucocorticoid, a drug used to treat glomerular diseases with proteinuria, might affect the phosphorylation of nephrin...
October 2011: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/21532157/inhibitory-effects-of-dexamethasone-on-epidermal-growth-factor-induced-dna-synthesis-and-proliferation-in-primary-cultures-of-adult-rat-hepatocytes
#10
Mitsutoshi Kimura, Hajime Moteki, Masahiko Ogihara
We investigated the effects of dexamethasone on epidermal growth factor (EGF)-induced DNA synthesis and proliferation in serum-free primary cultures of adult rat hepatocytes. Isolated hepatocytes were cultured at a density of 3.3 × 10⁴ cells/cm² in Williams' medium E containing 5% bovine calf serum and various concentrations of dexamethasone for 1, 2 and 3 h. After the 3-h attachment period, the medium was changed, and cells were cultured in serum-free and dexamethasone-free Williams' medium E with or without glucocorticoid receptor antagonists...
2011: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/21172366/influence-of-diurnal-phase-on-startle-response-in-adult-rats-exposed-to-dexamethasone-in-utero
#11
S L Kjaer, K S Hougaard, R A Tasker, D S MacDonald, R Rosenberg, B Elfving, G Wegener
Depression and pathological anxiety disorders are among the most prevalent neurological diseases in the world and can be precipitated and exacerbated by stress. Prenatal stress alters both behavioral and endocrine responses to stressful stimuli in later life. We have previously observed increased basal acoustic startle response (ASR) in Wistar rats exposed to stress or dexamethasone (DEX) in utero when tested during the light phase of the circadian rhythm, and decreased prepulse inhibition (PPI) in similar animals tested during the dark phase of the cycle...
March 28, 2011: Physiology & Behavior
https://www.readbyqxmd.com/read/20861841/high-plasma-aldosterone-concentration-is-a-novel-risk-factor-of-cognitive-impairment-in-patients-with-hypertension
#12
Shusuke Yagi, Masashi Akaike, Ken-ichi Aihara, Takashi Iwase, Sumiko Yoshida, Yuka Sumitomo-Ueda, Yasumasa Ikeda, Kazue Ishikawa, Toshio Matsumoto, Masataka Sata
Cognitive impairment leading to dementia is associated with high prevalence of hypertension, decreased quality of life and poor prognosis. Aldosterone is known as a risk factor for cardiovascular and cerebrovascular diseases. In addition, mineral corticoid receptors are abundantly expressed in the hippocampus, which plays a pivotal role in cognitive function; however, it has not been determined whether plasma aldosterone level is associated with cognitive impairment in patients with hypertension. We enrolled 68 patients with essential hypertension and assessed their cardiovascular risk factors, including blood pressure, hyperlipidemia, diabetes mellitus, obesity, smoking, history of cerebral infarction, renal function, parameters of inflammation, oxidative stress and nitric oxide bioavailability, a parameter of cerebral blood flow and carotid plaque by ultrasound examination, plasma renin activity and plasma aldosterone concentration (PAC)...
January 2011: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/18505847/corticosteroid-receptors-involved-in-stress-regulation-in-common-carp-cyprinus-carpio
#13
Ellen H Stolte, Aurélia F de Mazon, Karen M Leon-Koosterziel, Maria Jesiak, Nic R Bury, Armin Sturm, Huub F J Savelkoul, B M Lidy Verburg van Kemenade, Gert Flik
In higher vertebrates, mineralo- (aldosterone) and glucocorticoids (cortisol/corticosterone) exert their multiple actions via specific transcription factors, glucocorticoid (GR) and mineralocorticoid (MR) receptors. Teleostean fishes lack aldosterone and mineral regulatory processes seem under dominant control by cortisol. Despite the absence of the classical mineralocorticoid aldosterone, teleostean fishes do have an MR with cortisol and possibly 11-deoxycorticosterone (DOC) (as alternative for aldosterone) as predominant ligands...
August 2008: Journal of Endocrinology
https://www.readbyqxmd.com/read/18475157/crosstalk-between-the-heme-oxygenase-system-aldosterone-and-phospholipase-c-in-hypertension
#14
Joseph Fomusi Ndisang, Nina Lane, Ashok Jadhav
BACKGROUND: Aldosterone is a mineral corticoid hormone that is produced in response to angiotensin-II, and like angiotensin-II, stimulates inflammation, oxidative stress, and fibrosis by activating nuclear factor-kappaB and activating protein-1. Recent evidence, however, indicates that aldosterone stimulates phospholipase C and activates nuclear factor-kappaB and activating protein-1. Although the heme oxygenase system is cytoprotective, its effects on aldosterone-phospholipase C signaling in deoxycorticosterone acetate (DOCA-salt) hypertension, a model of aldosteronism, and spontaneously hypertensive rat, a genetic model of human essential hypertension, have not been fully characterized...
June 2008: Journal of Hypertension
https://www.readbyqxmd.com/read/17912848/-aldosterone-the-mechanisms-of-molecular-action
#15
REVIEW
N S Logvinenko
Aldosterone: a steroid hormone of adrenal cortex, has recently attracted much interest not only due to its great importance in regulation of salt and water balance, but also because of its key role in therapy of cardiovascular and renal pathology. The classical genomic mechanism of molecular action of aldosterone is mediated through interaction with mineral-corticoid receptors. Fast nongenomic pathway of cell signal transduction begins with interaction with hypothetic membrane receptors and includes activation of different kinase cascades...
July 2007: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
https://www.readbyqxmd.com/read/17447595/-from-gene-to-disease-apparent-mineralocorticoid-excess-syndrome-a-syndrome-with-an-apparent-excess-of-mineral-corticoids
#16
REVIEW
E N Levtchenko, J Deinum, N V A M Knoers, A R Hermus, L A H Monnens, J W M Lenders
Apparent mineralocorticoid excess (AME) is an autosomal recessive disease caused by deficiency of the enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2). 11beta-HSD2 converts cortisol into inactive cortisone and prevents the stimulation of the mineralocorticoid receptor by cortisol. In patients with AME, an enhanced stimulation of mineralocorticoid receptors by cortisol in the distal nephron causes an elevated sodium reabsorption and increased potassium excretion. Sodium retention leads to severe low renin hypertension...
March 24, 2007: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/17335916/involvement-of-noradrenergic-and-corticoid-receptors-in-the-consolidation-of-the-lasting-anxiogenic-effects-of-predator-stress
#17
R Adamec, C Muir, M Grimes, K Pearcey
The roles of beta-NER (beta-noradrenergic receptor), GR (glucocorticoid) and mineral corticoid receptors (MR) in the consolidation of anxiogenic effects of predator stress were studied. One minute after predator stress, different groups of rats were injected (ip) with vehicle, propranolol (beta-NER blocker, 5 and 10 mg/kg), mifepristone (RU486, GR blocker, 20 mg/kg), spironolactone (MR blocker, 50 mg/kg), propranolol (5 mg/kg) plus RU486 (20 mg/kg) or the anxiolytic, chloradiazepoxide (CPZ, 10 mg/kg). One week later, rodent anxiety was assessed in elevated plus maze, hole board, light/dark box, social interaction and acoustic startle...
May 16, 2007: Behavioural Brain Research
https://www.readbyqxmd.com/read/16633994/-use-of-diuretics-in-congestive-heart-failure-renal-effects
#18
M Timio, P Saronio, S Venanzi, G Bellomo, F Timio
Diuretics are an integral part of the management of symptomatic heart failure. Although they have been used for several decades, there is still some ambiguity and confusion regarding the outcome and the optimal way of using these common agents. There are no large-scale randomized controlled trials that have evaluated the effect of diuretics on mortality and long-term morbidity in diastolic and systolic dysfunction. Nonetheless, in short-term studies furosemide has demonstrated to reduce symptomatic congestive heart failure and hospitalization, and to improve exercise capacity in the setting of systolic dysfunction...
January 2006: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/12759331/how-estrogen-specific-proteins-discriminate-estrogens-from-androgens-a-common-steroid-binding-site-architecture
#19
Virginie Nahoum, Anne Gangloff, Rong Shi, Sheng-Xiang Lin
Steroid hormones play an essential role in a wide range of physiological and pathological processes, such as growth, metabolism, aging, and hormone-sensitive cancers. Estrogens are no exception and influence growth, differentiation, and functioning of many target tissues, such as the mammary gland, uterus, hypothalamus, pituitary, bone, and liver. Although very similar in structure, each steroid class (i.e., estrogens, androgens, progestins, mineral corticoids, or glucocorticoids) is responsible for distinct physiological processes...
July 2003: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/12653034/-aldosterone-and-its-antagonists-in-heart-failure
#20
REVIEW
M E Lopes, P Le Corvoisier, J Y Tabet, J B Su, T Badoual, J C Cachin, P Merlet, A Castaigne, L Hittinger
UNLABELLED: THE ROLE OF ALDOSTERONE: Aldosterone is the key hormone in salt-water homeostasis. In heart failure, it participates in the appearance and maintenance of signs of congestion. Predominantly synthesised in the glomerular area of the cortico-adrenal glands, extra adrenal production areas have recently been identified notably in the brain, the heart and the large artery trunks. Aldosterone is activated in the cells by the intracellular mineral corticoid receptor. IN CARDIOVASCULAR-PATHOLOGIES: In chronic heart failure, patients treated with conversion enzyme inhibitor may escape from the renin-angiotensin blockade and this may lead to increased aldosterone plasma levels...
January 18, 2003: La Presse Médicale
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