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https://www.readbyqxmd.com/read/29666343/interleukin-gene-polymorphisms-and-susceptibility-to-hiv-1-infection-a-meta-analysis
#1
Chrissa G Tsiara, Georgios K Nikolopoulos, Niki L Dimou, Katerina G Pantavou, Pantelis G Bagos, Benedicta Mensah, Michael Talias, Georgia G Braliou, Dimitra Paraskeva, Stefanos Bonovas, Angelos Hatzakis
Some subjects are repeatedly exposed to human immunodeficiency virus (HIV), yet they remain uninfected. This suggests the existence of host-resistance mechanisms. The current study synthesizes the evidence regarding the association between interleukin (IL) gene polymorphisms and HIV susceptibility. Medline, Scopus and the Web of Science databases were systematically searched, and a meta-analysis of case-control studies was conducted. Univariate and bivariate methods were used. The literature search identified 42 eligible studies involving 15,727 subjects...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29665069/generic-velpatasvir-plus-sofosbuvir-for-hepatitis-c-virus-infection-in-patients-with-or-without-human-immunodeficiency-virus-coinfection
#2
C-H Liu, H-Y Sun, C-J Liu, W-H Sheng, S-M Hsieh, Y-C Lo, W-C Liu, T-H Su, H-C Yang, C-M Hong, T-C Tseng, P-J Chen, D-S Chen, C-C Hung, J-H Kao
BACKGROUND: Data are limited regarding the effectiveness and safety of generic velpatasvir plus sofosbuvir (VEL/SOF) for hepatitis C virus (HCV) in patients with or without human immunodeficiency virus (HIV) coinfection. AIM: To evaluate the effectiveness and safety of generic VEL/SOF-based therapy for HCV infection in patients with or without HIV coinfection in Taiwan. METHODS: Sixty-nine HIV/HCV-coinfected and 159 HCV-monoinfected patients receiving 12 weeks of generic VEL/SOF with or without ribavirin (RBV) for HCV were prospectively enrolled...
April 17, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29661260/implementing-routine-blood-borne-virus-testing-for-hcv-hbv-and-hiv-at-a-london-emergency-department-uncovering-the-iceberg
#3
S Parry, N Bundle, S Ullah, G R Foster, K Ahmad, C Y W Tong, S Balasegaram, C Orkin
UK guidelines recommend routine HIV testing in high prevalence emergency departments (ED) and targeted testing for HBV and HCV. The 'Going Viral' campaign implemented opt-out blood-borne virus (BBV) testing in adults in a high prevalence ED, to assess seroprevalence, uptake, linkage to care (LTC) rates and staff time taken to achieve LTC. Diagnosis status (new/known/unknown), current engagement in care, and severity of disease was established. LTC was defined as patient informed plus ⩾1 clinic visit. A total of 6211/24 981 ED attendees were tested (uptake 25%); 257 (4...
April 17, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29660224/shortened-therapy-of-eight-weeks-with-paritaprevir-ritonavir-ombitasvir-and-dasabuvir-is-highly-effective-in-people-with-recent-hcv-genotype-1-infection
#4
Marianne Martinello, Sanjay Bhagani, Edward Gane, Chloe Orkin, Graham Cooke, Gregory J Dore, Kathy Petoumenos, Tanya L Applegate, Elise Tu, Philippa Marks, Nicole Pagani, Jason Grebely, Mark Nelson, Gail V Matthews
Paritaprevir/ritonavir/ombitasvir and dasabuvir with or without ribavirin for 12 weeks is approved for treatment of chronic HCV genotype 1 infection. This study assessed the efficacy of shortened duration paritaprevir/ritonavir/ombitasvir and dasabuvir with or without ribavirin for eight weeks among people with recent HCV infection. In this open-label single-arm trial conducted in Australia, England and New Zealand, adults with recent HCV (duration of infection <12 months) received paritaprevir/ritonavir/ombitasvir and dasabuvir (with weight-based ribavirin for genotype 1a and 1, no subtype) for eight weeks...
April 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29642845/prognostic-value-of-liver-stiffness-in-hiv-hcv-coinfected-patients-with-decompensated-cirrhosis
#5
Leire Pérez-Latorre, Matilde Sánchez-Conde, Pilar Miralles, Juan Carlos López, Francisco Parras, Francisco Tejerina, Teresa Aldámiz-Echevarría, Ana Carrero, Cristina Díez, Margarita Ramírez, Isabel Gutiérrez, José María Bellón, Rafael Bañares, Juan Berenguer
BACKGROUND: Little is known about the utility of transient elastography (TE) for assessing the prognosis of patients with decompensated cirrhosis (DC). METHODS: We analyzed HIV/HCV-coinfected patients with DC who underwent TE as part of their routine follow-up between 2006 and 2015. We also calculated the liver stiffness spleen diameter-to-platelet score (LSPS), FIB-4 index, albumin, MELD score, and Child-Pugh score. The primary outcome was death. RESULTS: The study population comprised 65 patients...
April 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29630030/hiv-serostatus-and-having-access-to-a-physician-for-regular-hepatitis-c-virus-care-among-people-who-inject-drugs
#6
Tara Beaulieu, Kanna Hayashi, Michael J Milloy, Ekaterina Nosova, Kora DeBeck, Julio Montaner, Thomas Kerr, Lianping Ti
BACKGROUND: People who inject drugs (PWIDs) and who are living with HIV and hepatitis C virus (HCV) infection are vulnerable to a range of health-related harms, including liver cirrhosis, hepatocellular carcinoma, and death. There is limited evidence describing how HIV serostatus shapes access to a physician for regular HCV care among PWID. SETTING: Data were collected through the Vancouver Injection Drug Users Study (VIDUS), the AIDS Care Cohort to evaluate Exposure to Survival Services (ACCESS), and the At-Risk Youth Study (ARYS), 3 prospective cohorts involving people who use illicit drugs in Vancouver, Canada, between 2005 and 2015...
May 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29627991/rural-incarcerated-women-hiv-hcv-knowledge-and-correlates-of-risky-behavior
#7
Bridgette Peteet, Michele Staton, Brittany Miller-Roenigk, Adam Carle, Carrie Oser
Rural incarcerated women have an increased risk of acquiring the human immunodeficiency virus (HIV) and the hepatitis C virus (HCV) due to prevalent engagement in drug use and sexual behaviors. Limited research has investigated HIV and HCV knowledge in this high-risk population. Furthermore, the interplay of sociodemographic factors (i.e., education, age, income, and sexual orientation) and risky behavior is understudied in this population. The present study evaluated a sample of adult, predominately White women from rural Kentucky ( n = 387) who were recruited from local jails...
April 1, 2018: Health Education & Behavior: the Official Publication of the Society for Public Health Education
https://www.readbyqxmd.com/read/29625021/hepatitis-c-viral-load-in-hcv-monoinfected-and-hcv-hiv-1-hcv-htlv-1-2-and-hcv-hiv-htlv-1-2-co-infected-patients-from-s%C3%A3-o-paulo-brazil
#8
Fabiana Aparecida Alves, Karoline Rodrigues Campos, Marcílio Figueiredo Lemos, Regina Célia Moreira, Adele Caterino-de-Araujo
Co-infections of hepatitis C virus (HCV) and either human immunodeficiency virus type 1 (HIV-1), human T-cell lymphotropic virus type 1 (HTLV-1) or type 2 (HTLV-2) have been described as having an impact on HCV viremia and subsequent disease progression. HCV load in serum samples from 622 patients (343 males, 279 females; median age 50.8 years) from São Paulo/southeast Brazil was analyzed using the Abbott Real Time HCV assay (Abbott Molecular Inc., IL, USA). Samples were obtained from HCV-monoinfected (n=548), HCV/HIV-1- (n=41), HCV/HTLV-1- (n=16), HCV/HTLV-2- (n=8), HCV/HIV/HTLV-1- (n=4), and HCV/HIV/HTLV-2-co-infected (n=5) patients, and results were compared among the groups and according to sex...
April 3, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29623036/the-aging-brain-with-hiv-infection-effects-of-alcoholism-or-hepatitis-c-comorbidity
#9
REVIEW
Natalie M Zahr
As successfully treated individuals with Human Immunodeficiency Virus (HIV)-infected age, cognitive and health challenges of normal aging ensue, burdened by HIV, treatment side effects, and high prevalence comorbidities, notably, Alcohol Use Disorders (AUD) and Hepatitis C virus (HCV) infection. In 2013, people over 55 years old accounted for 26% of the estimated number of people living with HIV (~1.2 million). The aging brain is increasingly vulnerable to endogenous and exogenous insult which, coupled with HIV infection and comorbid risk factors, can lead to additive or synergistic effects on cognitive and motor function...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29617599/public-health-conditions-for-successful-broad-scale-integration-of-hiv-and-hcv-screening-in-emergency-departments
#10
Erik S Anderson, Douglas A E White
No abstract text is available yet for this article.
May 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29608613/proteomic-fingerprinting-in-hiv-hcv-co-infection-reveals-serum-biomarkers-for-the-diagnosis-of-fibrosis-staging
#11
Makan Golizeh, Carlos E Melendez-Pena, Brian J Ward, Sahar Saeed, Cynthia Santamaria, Brian Conway, Curtis Cooper, Marina B Klein, Momar Ndao
BACKGROUND: Hepatic complications of hepatitis C virus (HCV), including fibrosis and cirrhosis are accelerated in human immunodeficiency virus (HIV)-infected individuals. Although, liver biopsy remains the gold standard for staging HCV-associated liver disease, this test can result in serious complications and is subject to sampling errors. These challenges have prompted a search for non-invasive methods for liver fibrosis staging. To this end, we compared serum proteome profiles at different stages of fibrosis in HIV/HCV co- and HCV mono-infected patients using surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF MS)...
2018: PloS One
https://www.readbyqxmd.com/read/29607354/consequence-of-hiv-and-hcv-co-infection-on-host-immune-response-persistence-and-current-treatment-options
#12
REVIEW
Sayed Sartaj Sohrab, Mohd Suhail, Ashraf Ali, Ishtiaq Qadri, Steve Harakeh, Esam I Azhar
Hepatitis C virus (HCV) is a common opportunistic pathogen especially among Human immunodeficiency virus (HIV) infected patients. Due to incongruous studies, the pathological effect of HCV on HIV induced disease are still not fully understood. While some studies have showed no effect of HCV on HIV infection, others reported a defined role of HCV in aggravating the rates of AIDS-related illnesses and mortality. The explanation of such variances may be due to the host immune response, viral genotypes, sub-type and quasi-species distribution...
March 2018: Virusdisease
https://www.readbyqxmd.com/read/29606698/an-education-and-field-experience-program-to-increase-detection-of-human-immunodeficiency-virus-and-hepatitis-c-virus
#13
Risha Irvin, Ayesha McAdams-Mahmoud, Jordan White, Zackiya Grant, Oluwaseun Falade-Nwulia, Susan Sherman, Chris Beyrer, Mark Sulkowski, David L Thomas, Shruti H Mehta, Richard Chaisson
BACKGROUND: Baltimore is an urban center that has been highly impacted by human immunodeficiency virus (HIV) and hepatitis C virus (HCV); however, many individuals are unaware of their HIV and/or HCV status. In 2013, the Johns Hopkins Center for AIDS Research (CFAR) developed Generation Tomorrow, an HIV and HCV education, testing, and counseling program with community input and collaboration. OBJECTIVES: The aims of Generation Tomorrow are to increase HIV and HCV awareness and detection in Baltimore and engage the next generation of health professionals (students) and community members (peers) in HIV and HCV outreach services...
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29606088/prevalence-of-hepatitis-b-virus-hepatitis-c-virus-human-immunodeficiency-virus-and-treponema-pallidum-infections-in-hospitalized-patients-before-transfusion-in-xiangya-hospital-central-south-university-china-from-2011-to-2016
#14
Wei-Wei Cao, Rong-Rong Zhou, Xinghua Ou, Ling-Xi Shi, Chao-Qi Xiao, Ting-Yin Chen, Hua Tan, Xue-Gong Fan, Bi-Juan Li, Ning Li
BACKGROUND: Human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and Treponema pallidum (TP) infections are considered classic transfusion-transmissible infections (TTIs). Few data are available about the prevalence of TTIs in patients before blood transfusion in China. This study aimed to investigate the seroprevalence of four TTIs among patients before blood transfusion in Xiangya Hospital Central South University, China. METHODS: From 2011 to 2016, 442,121 hospitalized patients before possible blood transfusion were tested for hepatitis B surface antigen (HBsAg), anti-HCV, syphilis antibody (anti-TP) and anti-HIV...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29604196/occupational-exposure-to-blood-and-bodily-fluids-among-healthcare-workers-in-serbian-general-hospitals
#15
Bojana Mandić, Stefan Mandić-Rajčević, Ljiljana Marković-Denić, Petar Bulat
The risk of occupational bloodborne infections (HBV, HCV, and HIV) among healthcare workers remains a serious issue in developing countries. The aim of this study was to estimate occupational exposure to bloodborne infections among general hospital workers in Serbia. This cross-sectional study was conducted in the spring of 2013 and included 5,247 healthcare workers from 17 general hospitals. The questionnaire was anonymous, self-completed, and included sociodemographic information with details of blood and bodily fluid exposure over the career and in the previous year (2012)...
March 1, 2018: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29601403/differential-timing-of-cholesterol-increase-during-successful-hcv-therapy-impact-of-type-of-drug-combination
#16
Antonio Rivero-Juarez, Angela Camacho, Teresa Brieva, Mario Frias, Pedro Lopez-Lopez, María A Risalde, Isabel Machuca, Juan J Caston, Antonio Martínez Peinado, Antonio Rivero
OBJECTIVE: to evaluate factors associated with increased serum cholesterol levels during Interferon-free (IFN-free) Hepatitis C virus (HCV) therapy. DESIGN: Prospective longitudinal study METHODS:: HIV-infected patients who started and successfully completed IFN-free therapy for chronic HCV infection were included. Patients were treated using two different regimens, based on the clinician's opinion: sofosbuvir and ledipasvir (SOF/LDV), or paritaprevir co-administered with ombitasvir and Dasabuvir (PrOD)...
March 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29596464/potential-geographic-hotspots-for-drug-injection-related-transmission-of-hiv-and-hcv-and-for-initiation-into-injecting-drug-use-in-new-york-city-2011-2015-with-implications-for-the-current-opioid-epidemic-in-the-us
#17
D C Des Jarlais, H L F Cooper, K Arasteh, J Feelemyer, C McKnight, Z Ross
OBJECTIVE: We identified potential geographic "hotspots" for drug-injecting transmission of HIV and hepatitis C virus (HCV) among persons who inject drugs (PWID) in New York City. The HIV epidemic among PWID is currently in an "end of the epidemic" stage, while HCV is in a continuing, high prevalence (> 50%) stage. METHODS: We recruited 910 PWID entering Mount Sinai Beth Israel substance use treatment programs from 2011-2015. Structured interviews and HIV/ HCV testing were conducted...
2018: PloS One
https://www.readbyqxmd.com/read/29596108/hepatocellular-carcinoma-after-sustained-virological-response-with-interferon-free-regimens-in-hiv-hcv-coinfected-patients
#18
Nicolás Merchante, Francisco Rodríguez-Arrondo, Boris Revollo, Esperanza Merino, Sofía Ibarra, María J Galindo, Marta Montero, Miguel García-Deltoro, Antonio Rivero-Juárez, Francisco Téllez, Marcial Delgado-Fernández, María J Ríos-Villegas, María A García, Francisco J Vera-Méndez, Guillermo Ojeda-Burgos, Miguel A López-Ruz, Luis Metola, Mohamed Omar, María Remedios Alemán-Valls, Koldo Aguirrebengoa, Joseba Portu, Miguel Raffo, Juan Macías, Juan A Pineda
OBJECTIVE: To assess the possible association between the use of direct antiviral agents (DAA) and the risk of hepatocellular carcinoma (HCC) in HIV/HCV-coinfected patients. METHODS: The GEHEP-002 cohort recruits HCC cases in HIV-infected patients from 32 centers from Spain. Three analyses were performed: the proportion of HCC cases after sustained virological response (SVR) and the evolution of this proportion over time, the frequency of HCC after SVR in HIV/HCV-coinfected patients with cirrhosis, and the probability of HCC recurrence after curative therapies among those undergoing HCV therapy...
March 28, 2018: AIDS
https://www.readbyqxmd.com/read/29595065/protease-inhibitor-therapy-for-hepatitis-c-virus-infection
#19
P de Leuw, C Stephan
The hepatitis C virus (HCV) has affected an estimated of 80 million individuals worldwide and is a strain on public health. Around 25-30% of patients in Europe and the US who are infected with HIV are coinfected with HCV. Prior to 2013, treatment modalities containing an NS3/4A protease inhibitor in combination with pegylated interferon and ribavirin improved sustained virological response (SVR) rates. However, rates of severe side effects were high. Nowadays, oral direct-acting antiviral (DAA) combination therapy offers excellent treatment efficacy, safety and tolerability...
April 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29594179/intervention-packages-to-reduce-the-impact-of-hiv-and-hcv-infections-among-people-who-inject-drugs-in-eastern-europe-and-central-asia-a-modeling-and-cost-effectiveness-study
#20
Guillaume Mabileau, Otilia Scutelniciuc, Maia Tsereteli, Ivan Konorazov, Alla Yelizaryeva, Svetlana Popovici, Karimov Saifuddin, Elena Losina, Manoela Manova, Vinay Saldanha, Jean-Elie Malkin, Yazdan Yazdanpanah
Background: We evaluated the effectiveness and cost-effectiveness of interventions targeting hepatitis C virus (HCV) and HIV infections among people who inject drugs (PWID) in Eastern Europe/Central Asia. We specifically considered the needle-syringe program (NSP), opioid substitution therapy (OST), HCV and HIV diagnosis, antiretroviral therapy (ART), and/or new HCV treatment (direct acting antiviral [DAA]) in Belarus, Georgia, Kazakhstan, Republic of Moldova, and Tajikistan. Methods: We developed a deterministic dynamic compartmental model and evaluated the number of infections averted, costs, and incremental cost-effectiveness ratios (ICERs) of interventions...
March 2018: Open Forum Infectious Diseases
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