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https://www.readbyqxmd.com/read/29214737/efficacy-safety-and-patient-reported-outcomes-of-ledipasvir-sofosbuvir-in-ns3-4a-protease-inhibitor-experienced-individuals-with-hepatitis-c-virus-genotype-1-and-hiv-coinfection-with-and-without-cirrhosis-anrs-hc31-softrih-study
#1
E Rosenthal, C Fougerou-Leurent, A Renault, M P Carrieri, F Marcellin, R Garraffo, E Teicher, H Aumaitre, K Lacombe, F Bailly, E Billaud, S Chevaliez, S Dominguez, M A Valantin, J Reynes, A Naqvi, L Cotte, S Metivier, V Leroy, M Dupon, T Allegre, P De Truchis, V Jeantils, J Chas, D Salmon-Ceron, P Morlat, D Neau, P Perré, L Piroth, S Pol, M Bourlière, G P Pageaux, L Alric, D Zucman, P M Girard, I Poizot-Martin, Y Yazdanpanah, F Raffi, E Le Pabic, C Tual, A Pailhé, I Amri, E Bellissant, J M Molina
OBJECTIVES: Studies evaluating the efficacy and safety of the fixed-dose combination ledipasvir (LDV)/sofosbuvir (SOF) in patients coinfected with HIV-1 and hepatitis C virus (HCV) have mainly included treatment-naïve patients without cirrhosis. We aimed to evaluate the efficacy and safety of this combination in treatment-experienced patients with and without cirrhosis. METHODS: We conducted a multicentre, open-label, double-arm, nonrandomized study in patients coinfected with HIV-1 and HCV genotype 1 with and without cirrhosis, who had good viral suppression on their antiretroviral regimens...
December 7, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29211835/massive-iatrogenic-outbreak-of-human-immunodeficiency-virus-type-1-in-rural-cambodia-2014-2015
#2
François Rouet, Janin Nouhin, Du-Ping Zheng, Benjamin Roche, Allison Black, Sophearot Prak, Marie Leoz, Catherine Gaudy-Graffin, Laurent Ferradini, Chandara Mom, Sovatha Mam, Charlotte Gautier, Gérard Lesage, Sreymom Ken, Kerya Phon, Alexandra Kerleguer, Chunfu Yang, William Killam, Masami Fujita, Chhivun Mean, Didier Fontenille, Francis Barin, Jean-Christophe Plantier, Trevor Bedford, Artur Ramos, Vonthanak Saphonn
Background: In 2014-2015, 242 individuals aged 2-89 were newly HIV-1 diagnosed in Roka, a rural commune in Cambodia. A case-control study attributed the outbreak to unsafe injections. We aimed to reconstruct the likely transmission history of the outbreak. Methods: We assessed in 209 (86.4%) HIV-infected cases the presence of hepatitis C and B viruses (HCV, HBV). We identified recent infections using antibody (Ab) avidity testing for HIV and HCV, and HBcIgM Ab for HBV...
December 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29211347/long-term-viral-suppression-and-immune-recovery-during-first-line-antiretroviral-therapy-a-study-of-an-hiv-infected-adult-cohort-in-hanoi-vietnam
#3
Junko Tanuma, Shoko Matsumoto, Sebastien Haneuse, Do Duy Cuong, Tuong Van Vu, Pham Thi Thanh Thuy, Nguyen Thi Dung, Nguyen Thi Hoai Dung, Nguyen Vu Trung, Nguyen Van Kinh, Shinichi Oka
INTRODUCTION: Achieving viral suppression is key in the global strategy to end the HIV epidemic. However, the levels of viral suppression have yet to be described in many resource-limited settings. METHODS: We investigated the time to virologic failure (VF; defined as a viral load of ≥1000 copies/ml) and changes in CD4 counts since starting antiretroviral therapy (ART) in a cohort of HIV-infected adults in Hanoi, Vietnam. Factors related to the time to VF and impaired early immune recovery (defined as not attaining an increase in 100 cells/mm3 in CD4 counts at 24 months) were further analysed...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29210779/remarkable-plasma-hiv-rna-decrease-by-ombitasvir-paritaprevir-ritonavir-in-an-hiv-hcv-coinfection-case
#4
Yukihiro Yoshimura, Nobuyuki Miyata, Hirokazu Komatsu, Natsuo Tachikawa
No abstract text is available yet for this article.
January 2, 2018: AIDS
https://www.readbyqxmd.com/read/29209789/-novel-aspects-of-the-guidelines-for-hemotherapy-2017-implications-for-anesthesiology
#5
REVIEW
I Pekrul, G Wittmann, P Möhnle
Based on the German Transfusion Law, the periodically updated guidelines "Richtlinien zur Gewinnung von Blut und Blutbestandteilen und zur Anwendung von Blutprodukten" ("Hämotherapierichtlinien") are intended to provide the current knowledge and state of the art of blood transfusion practice in Germany. The novel update 2017 contains relevant changes for blood donation, especially the extension of the exclusion period of persons at risk for sexually transmitted HBV, HCV and HIV diseases to 12 months. Moreover, the guidelines provide several changes relevant to blood transfusion practice in anesthesiology, such as: all autologous hemotherapy procedures including normovolemic hemodilution, cell saver, and autologous blood donation and transfusion require formal registration at the regulatory authority...
December 5, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/29208530/analytical-performances-of-simultaneous-detection-of-hiv-1-hiv-2-and-hepatitis-c-specific-antibodies-and-hepatitis-b-surface-antigen-hbsag-by-multiplex-immunochromatographic-rapid-test-with-serum-samples-a-cross-sectional-study
#6
Leman Robin, Ralph-Sydney Mboumba Bouassa, Zita Ayelo, Laura Charmant, Mathieu Matta, Sylvie Simon, Mounir Filali, Souleymane Mboup, Laurent Bélec
BACKGROUND: The HIV/HCV/HBsAg Triplex [OEM: Biotest Biotech Inc, Hangzhou, China] consists in manually performed, visually interpreted, lateral flow, immunochromatographic rapid diagnostic test simultaneously detecting in 15minutes human immunodeficiency virus (HIV)-1 and HIV-2 and hepatitis C virus (HCV)- specific antibodies (Ab) (IgG and IgM) and hepatitis B virus (HBV) surface antigen (HBsAg) in serum, plasma and whole blood. METHODS: A hospital-based cross-sectional study was conducted on a prospective panel of serum samples from adult inpatients included from routine analysis irrespectively of age and sex, including 250 sera positive for HIV-1-specific Ab, 250 for HCV-specific Ab, 250 for HBsAg and 250 sera negative for HIV- and HCV- Ab and HBsAg, and from 110 HIV-2-infected patients living in Ivory Coast, according to the results obtained by the reference chemiluminiscent microparticle immunoassay (CMIA) Abbott Architect i2000SR analyzer (Abbott Diagnostic, Chicago, IL, USA)...
December 2, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29206853/proportion-and-factors-associated-with-recent-hiv-infection-in-a-cohort-of-patients-seen-for-care-in-italy-over-1996-2014-data-from-the-icona-foundation-study-cohort
#7
Silvia Nozza, Alessandro Cozzi-Lepri, Francesca Bai, Stefano Rusconi, Andrea Gori, Paola Cinque, Adriana Ammassari, Pietro Caramello, Giuseppe Tambussi, Antonella D'Arminio Monforte, Giulia Marchetti
In Italy the prevalence of recent HIV infection (RHI) isn't currently monitored. Early diagnosis is crucial to allow introduction of antiretroviral therapy (cART) in the recent phase of infection. We aimed to estimate the proportion and the determinants of RHI among patients enrolled in the ICONA cohort; we explored differences in the median time from HIV diagnosis to cART initiation and in the viro-immunological response between RHI and Less Recent HIV infections (NRHI). We included antiretroviral-naïve HIV-positive patients enrolled in the cohort with documented dates of HIV-negative and positive antibodies tests, grouped in RHI (estimated date of seroconversion within 12 months of enrolment) and NRHI...
2017: PloS One
https://www.readbyqxmd.com/read/29198873/short-and-long-term-postoperative-complications-following-total-joint-arthroplasty-in-patients-with-human-immunodeficiency-virus-hepatitis-b-or-hepatitis-c
#8
Beau J Kildow, Cary S Politzer, Marcus DiLallo, Michael P Bolognesi, Thorsten M Seyler
INTRODUCTION: Due to advancement in treatment against human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV), the prevalence of this patient population electing to undergo total joint arthroplasty (TJA) is increasing. Current literature is scarce and conflicting especially when evaluating long-term surgical complications. The purpose of this study is to assess the postoperative medical and surgical complications following TJA in these patient populations...
November 13, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29194939/management-of-drug-interactions-with-direct-acting-antivirals-in-dutch-hiv-hepatitis-c-virus-coinfected-patients-adequate-but-not-perfect
#9
E J Smolders, C Smit, Ctmm de Kanter, Asm Dofferhoff, J E Arends, K Brinkman, B Rijnders, M van der Valk, P Reiss, D M Burger
OBJECTIVES: Direct-acting antivirals (DAAs) for treatment of chronic hepatitis C virus (HCV) infection can cause drug-drug interactions (DDIs) with combination antiretroviral therapy (cART) and non-cART co-medication. We mapped how physicians manage DDIs between DAAs and co-medication and analysed treatment outcomes. METHODS: Data were prospectively collected as part of the ATHENA HIV observational cohort and retrospectively analysed. Dutch patients with HIV/HCV coinfection who initiated treatment with DAAs between January 2015 and May 2016 were included...
December 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29194114/hiv-1-and-hepatitis-c-virus-selection-bottleneck-in-chinese-people-who-inject-drugs
#10
Fan Li, Liying Ma, Yi Feng, Yuhua Ruan, Jing Hu, Hongshuo Song, Pengtao Liu, Jun Ma, Baolin Rui, Kate Kerpen, Benjamin Scheinfeld, Tuhina Srivastava, Metzger David, Hui Li, Katharine J Bar, Yiming Shao
OBJECTIVES: For both HIV-1 and hepatitis C virus (HCV), assessing the stringency of the transmission process is a scientific priority. Enumerations of transmitted/founder (TF) viruses have shown a strict transmission bottleneck in sexual transmission of HIV-1 and a wide range in the multiplicity of infection in HCV. Here, we aim to determine the stringency of parenteral transmission for HIV -1 and HCV in people who inject drugs (PWID). DESIGN: We used molecular sequencing and several complementary analyses to enumerate the TF HIV-1 and HCV variants in a well-described cohort of PWID in Xinjiang, China...
November 30, 2017: AIDS
https://www.readbyqxmd.com/read/29193564/ifn-free-therapy-is-associated-with-restoration-of-type-i-ifn-response-in-hiv-1-patients-with-acute-hcv-infection-who-achieve-svr
#11
Charles Carlton-Smith, Jacinta A Holmes, Susanna Naggie, Anna Lidofsky, Georg M Lauer, Arthur Y Kim, Raymond T Chung
Interferon (IFN)-free direct-acting antiviral agents (DAAs) have revolutionized chronic hepatitis C virus (HCV) treatment; early studies suggest excellent efficacy in acute HCV. However, changes in innate immune responses during DAA therapy for acute HCV are unknown. We studied interferon-stimulated gene (ISG) expression and related cytokines/chemokines in HIV-infected patients with acute HCV receiving sofosbuvir plus ribavirin (SOF+RBV) as part of the A5327 clinical trial. ISG expression was determined from PBMCs and circulating cytokines/chemokines were quantified from serum from study participants...
November 29, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29193128/pathogen-reduction-and-blood-transfusion-safety-in-africa-strengths-limitations-and-challenges-of-implementation-in-low-resource-settings
#12
REVIEW
A D Ware, C Jacquot, A A R Tobian, E A Gehrie, P M Ness, E M Bloch
Transfusion-transmitted infection risk remains an enduring challenge to blood safety in Africa. A high background incidence and prevalence of the major transfusion-transmitted infections (TTIs), dependence on high-risk donors to meet demand, suboptimal testing and quality assurance collectively contribute to the increased risk. With few exceptions, donor testing is confined to serological evaluation of human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) and syphilis. Barriers to implementation of broader molecular methods include cost, limited infrastructure and lack of technical expertise...
November 30, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/29191154/hepatitis-c-testing-and-re-testing-among-people-attending-sexual-health-services-in-australia-and-hepatitis-c-incidence-among-people-with-human-immunodeficiency-virus-analysis-of-national-sentinel-surveillance-data
#13
David C Boettiger, Matthew G Law, Gregory J Dore, Rebecca Guy, Denton Callander, Basil Donovan, Catherine C O'Connor, Christopher K Fairley, Margaret Hellard, Gail Matthews
BACKGROUND: Direct acting antivirals are expected to drastically reduce the burden of hepatitis C virus (HCV) in people living with Human Immunodeficiency Virus (HIV). However, rates of HCV testing, re-testing and incident infection in this group remain uncertain in Australia. We assessed trends in HCV testing, re-testing and incident infection among HIV-positive individuals, and evaluated factors associated with HCV re-testing and incident infection. METHODS: The study population consisted of HIV-positive individuals who visited a sexual health service involved in the Australian Collaboration for Coordinated Enhanced Sentinel Surveillance (ACCESS) between 2007 and 2015...
December 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29186704/crf35-ad-as-the-main-circulating-genotype-of-human-immunodeficiency-virus-type-1-infection-in-iran-a-phylogenetic-and-demographic-based-study
#14
Sayed-Hamidreza Mozhgani, Seyedeh Arefeh Ebrahimian, Hoda Gudarzi, Seyed Mohammad Jazayeri, Fatemeh Jahanbakhsh, Minoo Mohraz, Seyed Abdolrahim Rezaee, Kayhan Azadmanesh, Saber Soltani, Mehdi Norouzi
Finding the predominant circulating subtype of human immunodeficiency virus type 1 (HIV-1) and surveying co-infection with other infectious viruses are crucial to making preventive decisions. To this end, 50 Iranian HIV-positive patients made up of 37 men and 13 women were selected. Most of the HIV-positive patients (70%) were intravenous drug users (IDUs), and 48 and 32% of patients were co-infected with HCV and HBV, respectively. The rate of simultaneous infection with HIV, HCV, and HBV was found to be 6%...
November 30, 2017: Intervirology
https://www.readbyqxmd.com/read/29186559/phyloscanner-inferring-transmission-from-within-and-between-host-pathogen-genetic-diversity
#15
Chris Wymant, Matthew Hall, Oliver Ratmann, David Bonsall, Tanya Golubchik, Mariateresa de Cesare, Astrid Gall, Marion Cornelissen, Christophe Fraser
A central feature of pathogen genomics is that different infectious particles (virions, bacterial cells, etc.) within an infected individual may be genetically distinct, with patterns of relatedness amongst infectious particles being the result of both within-host evolution and transmission from one host to the next. Here we present a new software tool, phyloscanner, which analyses pathogen diversity from multiple infected hosts. phyloscanner provides unprecedented resolution into the transmission process, allowing inference of the direction of transmission from sequence data alone...
November 23, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29186365/high-treatment-uptake-in-hiv-hcv-coinfected-patients-after-unrestricted-access-to-direct-acting-antivirals-in-the-netherlands
#16
Anne Boerekamps, Astrid M Newsum, Colette Smit, Joop E Arends, Clemens Richter, Peter Reiss, Bart J A Rijnders, Kees Brinkman, Marc van der Valk
Background: The Netherlands has provided unrestricted access to direct-acting antivirals (DAAs) since November 2015. We analyzed the nationwide HCV treatment uptake among HIV/HCV-coinfected patients. Methods: Data were obtained from the ATHENA HIV observational cohort in which >98% of HIV-infected patients ever registered since 1998 are included. Patients were included if they ever had 1 positive HCV RNA, did not spontaneously clear and were known to still be in care...
November 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29186320/declining-hcv-incidence-in-dutch-hiv-positive-men-who-have-sex-with-men-after-unrestricted-access-to-hcv-therapy
#17
Anne Boerekamps, Guido E Van den Berk, Lauw N Fanny, Eliane M Leyten, Marjo E Van Kasteren, Arne van Eeden, Dirk Posthouwer, Mark A Claassen, Anton S Dofferhoff, Dominique W M Verhagen, Wouter F Bierman, Kamilla D Lettinga, Frank P Kroon, Corine E Delsing, Paul H Groeneveld, Robert Soetekouw, Edgar J Peters, Sebastiaan J Hullegie, Stephanie Popping, David A M C Van de Vijver, Charles A Boucher, Joop E Arends, Bart J Rijnders
Background: Direct acting antivirals (DAA) cure 95% of patients infected with hepatitis C (HCV). Modeling studies predict that universal HCV treatment will lead to a decrease in the incidence of new infections but real-life data are lacking. The incidence of HCV among Dutch HIV-positive men who have sex with men (MSM) has been high for >10 years. In 2015 DAA became available to all Dutch HCV patients and resulted in a rapid treatment uptake in HIV-positive MSM. We assessed whether this uptake was followed by a decrease in the incidence of HCV infections...
November 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29185250/management-of-hepatitis-c-in-decentralised-versus-centralised-drug-substitution-programmes-and-minimally-invasive-point-of-care-tests-to-close-gaps-in-the-hcv-cascade
#18
Andrea Bregenzer, Anna Conen, Jürg Knuchel, Andrée Friedl, Franz Eigenmann, Martin Näf, Peter Ackle, Martin Roth, Christoph Andreas Fux
BACKGROUND: In Switzerland, intravenous drug use accounts for the majority of hepatitis C virus (HCV) infections. Early HCV treatment prevents further transmissions and reduces morbidity and mortality due to decompensated liver cirrhosis and hepatocellular carcinoma. Nevertheless, patients in drug substitution programmes are often insufficiently screened and treated. AIM: The aim was to compare the current state of HCV management in centralised and decentralised drug substitution programmes of the canton Aargau...
November 29, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29183287/hiv-and-hepatitis-b-and-c-co-infection-among-people-who-inject-drugs-in-zanzibar
#19
Ahmed Khatib, Eva Matiko, Farhat Khalid, Susie Welty, Ameir Ali, Asha Othman, Shaaban Haji, Mohammed Dahoma, George Rutherford
BACKGROUND: People who inject drugs are at high risk of acquiring hepatitis B (HBV), hepatitis C (HCV), and human immunodeficiency virus (HIV) due to risky injection and sexual practices. The objective of this study is to investigate the epidemiology of HIV, hepatitis B, and hepatitis C, and co-infection of these viruses among people who inject drugs in Zanzibar, Tanzania. METHODS: We used respondent-driven sampling to identify 408 participants, from whom we collected demographic data, information on sexual behaviours and injection drug practices, and blood samples for biological testing...
November 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29183228/recommendations-for-buprenorphine-and-methadone-therapy-in-opioid-use-disorder-a-european-consensus
#20
Maurice Dematteis, Marc Auriacombe, Oscar D'Agnone, Lorenzo Somaini, Néstor Szerman, Richard Littlewood, Farrukh Alam, Hannu Alho, Amine Benyamina, Julio Bobes, Jean Pierre Daulouede, Claudio Leonardi, Icro Maremmani, Marta Torrens, Stephan Walcher, Michael Soyka
Management of patients with opioid use disorder (OUD) commonly includes opioid agonist therapy (OAT) as a part of an integrated treatment plan. These interventions are associated with proven benefits to the individual and society. Areas covered: The use of methadone and buprenorphine within an integrated treatment plan in the management of patients with OUD: this work provides consensus recommendation on pharmacotherapy in OUD to assist clinicians with practical decision making in this field. Expert opinion: Pharmacotherapy is recommended as part of an integrated OUD treatment approach with psychosocial interventions, with the goal of reducing risks of illicit opioid use, overdose mortality, infection with HIV or HCV, improving health, psychological and social outcomes...
November 29, 2017: Expert Opinion on Pharmacotherapy
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