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https://www.readbyqxmd.com/read/28902846/downregulation-of-microrna-145-may-contribute-to-liver-fibrosis-in-biliary-atresia-by-targeting-add3
#1
Yongqin Ye, Zhihan Li, Qi Feng, Zimin Chen, Zhouguang Wu, Jianyao Wang, Xiaoshuo Ye, Dahao Zhang, Lei Liu, Wei Gao, Lihui Zhang, Bin Wang
BACKGROUND AND OBJECTIVES: Biliary atresia (BA) is a pediatric liver disease characterized by fibro-obliteration and obstruction of the extrahepatic biliary system, that invariably leads to cirrhosis and even death, if left untreated for extended time. However, its pathology and etiology still remained unknown. In this study, we tested the expression of adducin 3 (ADD3), the gene identified as a susceptibility gene in BA by GWAS, and uncovered its upstream regulatory microRNA in the pathogenesis of BA...
2017: PloS One
https://www.readbyqxmd.com/read/28748416/cryoprotective-effect-of-resveratrol-on-dna-damage-and-crucial-human-sperm-messenger-rnas-possibly-through-5-amp-activated-protein-kinase-activation
#2
Maryam Shabani Nashtaei, Saeid Nekoonam, Mohammad Naji, Shabnam Bakhshalizadeh, Fardin Amidi
This work aimed at investigating the effect of resveratrol on (1) DNA integrity and (2) fertilizing capacity of sperm by quantifying the presence of key paternal transcripts considered as markers for male fertility (protamine 1 [PRM1] and protamine 2 [PRM2]) and pregnancy success (adducin 1 alpha [ADD1]) in cryopreserved human spermatozoa through modulation of AMP-activated protein kinase (AMPK). The study populations was drawn from 22 normozoospermic healthy volunteers which were incubated with or without AMPK activator (resveratrol [RSV], 15 µM) or inhibitor (Compound C [CC], 30 µM) for 1 h and were then cryopreserved...
July 26, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28686109/%C3%AE-adducin-gene-promoter-dna-methylation-and-the-risk-of-essential-hypertension
#3
Nervana M K Bayoumy, Mohamed M El-Shabrawi, Ola Farouk Leheta, Hamdy Hassan Omar
This study was conducted to test the association between promoter DNA methylation of α-Adducin (ADD1) gene and the risk of essential hypertension (EH). A total of 150 EH patients and 100 aged- and gender-matched controls were investigated. DNA methylation levels of five cytosine-phosphate-guanine (CpG) dinucleotides on ADD1 promoter were measured employing bisulfite pyrosequencing technology. Our results showed that females have a higher ADD1 DNA methylation than males and a significantly lower CpG1 methylation level is associated with increased risk of EH among them...
July 7, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28648322/induction-of-type-2-diabetes-mellitus-with-antihypertensive-therapy-is-there-any-role-of-alpha-adducin-ace-and-irs-1-gene
#4
REVIEW
Sumeet Gupta, Vikas Jhawat
Hypertension and diabetes are related disorders that share common pathophysiological pathways and occur together. Although hypertension itself is a risk factor for developing diabetes, prolonged use of first-line antihypertensive therapy has also been reported to induce diabetes. Genetic polymorphism of genes affecting salt sensitivity and insulin resistance can have a role in antihypertensive therapy-induced diabetes. Polymorphism of the alpha adducin gene, angiotensin-converting enzyme gene, and insulin receptor substrate 1 gene has been found to be associated with new incident diabetes in hypertensive patients via salt sensitivity and insulin resistance...
May 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/28628114/oncoprotein-znf322a-transcriptionally-deregulates-alpha-adducin-cyclin-d1-and-p53-to-promote-tumor-growth-and-metastasis-in-lung-cancer
#5
J Jen, L-L Lin, F-Y Lo, H-T Chen, S-Y Liao, Y-A Tang, W-C Su, R Salgia, C-L Hsu, H-C Huang, H-F Juan, Y-C Wang
This corrects the article DOI: 10.1038/onc.2015.296.
September 7, 2017: Oncogene
https://www.readbyqxmd.com/read/28490361/adducin-family-proteins-possess-different-nuclear-export-potentials
#6
Chia-Mei Liu, Wen-Hsin Hsu, Wan-Yi Lin, Hong-Chen Chen
BACKGROUND: The adducin (ADD) family proteins, namely ADD1, ADD2, and ADD3, are actin-binding proteins that play important roles in the stabilization of membrane cytoskeleton and cell-cell junctions. All the ADD proteins contain a highly conserved bipartite nuclear localization signal (NLS) at the carboxyl termini, but only ADD1 can localize to the nucleus. The reason for this discrepancy is not clear. METHODS: To avoid the potential effect of cell-cell junctions on the distribution of ADD proteins, HA epitope-tagged ADD proteins and mutants were transiently expressed in NIH3T3 fibroblasts and their distribution in the cytoplasm and nucleus was examined by immunofluorescence staining...
May 10, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28476036/adducin-in-tumorigenesis-and-metastasis
#7
REVIEW
Cong Luo, Jiayu Shen
Adducin is a membrane-skeletal protein localized at spectrin-actin junctions, involving in the formation of the network of cytoskeleton, cellular signal transduction, ionic transportation, cell motility and cell proliferation. While previous researches focused mainly on the relationship between adducin and hypertension, there are few studies focusing on the role of adducin in tumor. Previous studies showed that adducin played a role in the evolution and progression of neoplasm. This review makes a brief summary on the structure, function and mechanism of adducin and how adducin functions in tumorigenesis and metastasis...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28368404/oncoprotein-znf322a-transcriptionally-deregulates-alpha-adducin-cyclin-d1-and-p53-to-promote-tumor-growth-and-metastasis-in-lung-cancer
#8
J Jen, L-L Lin, F-Y Lo, H-T Chen, S-Y Liao, Y-A Tang, W-C Su, R Salgia, C-L Hsu, H-C Huang, H-F Juan, Y-C Wang
This corrects the article DOI: 10.1038/onc.2015.296.
August 2017: Oncogene
https://www.readbyqxmd.com/read/28072414/evidence-for-genetic-heterogeneity-between-clinical-subtypes-of-bipolar-disorder
#9
A W Charney, D M Ruderfer, E A Stahl, J L Moran, K Chambert, R A Belliveau, L Forty, K Gordon-Smith, A Di Florio, P H Lee, E J Bromet, P F Buckley, M A Escamilla, A H Fanous, L J Fochtmann, D S Lehrer, D Malaspina, S R Marder, C P Morley, H Nicolini, D O Perkins, J J Rakofsky, M H Rapaport, H Medeiros, J L Sobell, E K Green, L Backlund, S E Bergen, A Juréus, M Schalling, P Lichtenstein, P Roussos, J A Knowles, I Jones, L A Jones, C M Hultman, R H Perlis, S M Purcell, S A McCarroll, C N Pato, M T Pato, N Craddock, M Landén, J W Smoller, P Sklar
We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta-analysis was performed with prior results from the Psychiatric Genomics Consortium Bipolar Disorder Working Group for a combined sample of 13 902 cases and 19 279 controls. We identified eight genome-wide significant, associated regions, including a novel associated region on chromosome 10 (rs10884920; P=3.28 × 10(-8)) that includes the brain-enriched cytoskeleton protein adducin 3 (ADD3), a non-coding RNA, and a neuropeptide-specific aminopeptidase P (XPNPEP1)...
January 10, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28040068/association-between-alpha-adducin-gene-rs4963-polymorphism-and-hypertension-risk-in-asian-population-a-meta-analysis
#10
Y-L Qu, C-M Wu, L-X Zhang, B-L Wen, X Zhang, C Ma, X-Y Yan, H-B Cui, D-M Wang, Y-R Ji
Some studies investigated the association between ADD1 rs4963 polymorphism and hypertension risk. However, the results remained inconclusive. Thus, we performed a meta-analysis. Published reports were searched in PubMed and Google Scholar. The strength of association was assessed by calculating odds ratios (OR) and 95% confidence interval (CI). Twelve studies with 5097 cases and 5937 controls were conducted in this study. Individuals with ADD1 rs4963 polymorphism showed an increased hypertension risk (OR = 1...
November 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27940662/deep-targeted-exon-sequencing-reveals-renal-polymorphisms-associate-with-postexercise-hypotension-among-african-americans
#11
Linda S Pescatello, Elizabeth D Schifano, Garrett I Ash, Gregory A Panza, Lauren Lamberti, Ming-Hui Chen, Ved Deshpande, Amanda Zaleski, Paulo Farinatti, Beth A Taylor, Paul D Thompson
We found variants from the Angiotensinogen-Converting Enzyme (ACE), Angiotensin Type 1 Receptor (AGTR1), Aldosterone Synthase (CYP11B2), and Adducin (ADD1) genes exhibited intensity-dependent associations with the ambulatory blood pressure (BP) response following acute exercise, or postexercise hypotension (PEH). In a validation cohort, we sequenced exons from these genes for their associations with PEH Obese (30.9 ± 3.6 kg m(-2)) adults (n = 23; 61% African Americans [AF], 39% Caucasian) 42.0 ± 9...
October 2016: Physiological Reports
https://www.readbyqxmd.com/read/27927653/knockdown-of-add3-impairs-the-myogenic-response-of-renal-afferent-arterioles-and-middle-cerebral-arteries
#12
Fan Fan, Mallikarjuna R Pabbidi, Ying Ge, Longyang Li, Shaoxun Wang, Paige N Mims, Richard J Roman
We have reported that the myogenic response of the renal afferent arteriole (Af-art) and middle cerebral artery (MCA) and autoregulation of renal and cerebral blood flow are impaired in Fawn-Hooded Hypertensive (FHH) rats. Transfer of a region of chromosome 1 containing γ-adducin (Add3) from the Brown Norway rat rescued the vascular dysfunction and the development of renal disease. To examine whether Add3 is a viable candidate gene altering renal and cerebral hemodynamics in FHH rats, we knocked down the expression of Add3 in rat Af-arts and MCAs cultured for 36-h using a 27-mer Dicer-substrate short interfering RNA (DsiRNA)...
June 1, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27881663/periodic-actin-structures-in-neuronal-axons-are-required-to-maintain-microtubules
#13
Yue Qu, Ines Hahn, Stephen E D Webb, Simon P Pearce, Andreas Prokop
Axons are cable-like neuronal processes wiring the nervous system. They contain parallel bundles of microtubules as structural backbones, surrounded by regularly spaced actin rings termed the periodic membrane skeleton (PMS). Despite being an evolutionarily conserved, ubiquitous, highly ordered feature of axons, the function of PMS is unknown. Here we studied PMS abundance, organization, and function, combining versatile Drosophila genetics with superresolution microscopy and various functional readouts. Analyses with 11 actin regulators and three actin-targeting drugs suggest that PMS contains short actin filaments that are depolymerization resistant and sensitive to spectrin, adducin, and nucleator deficiency, consistent with microscopy-derived models proposing PMS as specialized cortical actin...
January 15, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27834745/altered-expression-of-long-noncoding-rnas-in-blood-after-ischemic-stroke-and-proximity-to-putative-stroke-risk-loci
#14
Cheryl Dykstra-Aiello, Glen C Jickling, Bradley P Ander, Natasha Shroff, Xinhua Zhan, DaZhi Liu, Heather Hull, Miles Orantia, Boryana S Stamova, Frank R Sharp
BACKGROUND AND PURPOSE: Although peripheral blood mRNA and micro-RNA change after ischemic stroke, any role for long noncoding RNA (lncRNA), which comprise most of the genome and have been implicated in various diseases, is unknown. Thus, we hypothesized that lncRNA expression also changes after stroke. METHODS: lncRNA expression was assessed in 266 whole-blood RNA samples drawn once per individual from patients with ischemic stroke and matched with vascular risk factor controls...
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27526058/loss-of-a-candidate-biliary-atresia-susceptibility-gene-add3a-causes-biliary-developmental-defects-in-zebrafish
#15
Vivian Tang, Zenobia C Cofer, Shuang Cui, Valerie Sapp, Kathleen M Loomes, Randolph P Matthews
OBJECTIVES: Biliary atresia (BA) is a progressive fibroinflammatory cholangiopathy affecting the bile ducts of neonates. Although BA is the leading indication for pediatric liver transplantation, the etiology remains elusive. Adducin 3 (ADD3) and X-prolyl aminopeptidase 1 (XPNPEP1) are 2 genes previously identified in genome-wide association studies as potential BA susceptibility genes. Using zebrafish, we investigated the importance of ADD3 and XPNPEP1 in functional studies. METHODS: To determine whether loss of either gene leads to biliary defects, we performed morpholino antisense oligonucleotide (MO) knockdown studies targeting add3a and xpnpep1 in zebrafish...
November 2016: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27508835/-op-7c-03-klotho-gene-polymorphism-interacts-with-adducin-endogenous-ouabain-na-k-atpase-system-in-salt-sensitive-hypertension
#16
S Tentori, C Lanzani, L Citterio, E Brioni, M Simonini, L Zagato, E Messaggio, P Manunta
OBJECTIVE: The genetic basis of salt sensitive (SSH) hypertension consists in a very complex network of dynamic interaction among genetic-environmental factors that may change with aging. The existence of a regulatory genetic network (RGN) as triggering mechanism of SSH has been already postulated for Adducin-Endogenous Ouabain-Na+-K+ ATPase (ADD-EO-NKA) system. The observation that Klotho (KL) is a newly discovered aging suppressor gene can directly affect the Na+, K+-ATPase activity opening new possible interaction with the RGN...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27435097/identification-of-adducin-binding-residues-on-the-cytoplasmic-domain-of-erythrocyte-membrane-protein-band-3
#17
Taina Franco, Haiyan Chu, Philip S Low
Two major complexes form structural bridges that connect the erythrocyte membrane to its underlying spectrin-based cytoskeleton. Although the band 3-ankyrin bridge may account for most of the membrane-to-cytoskeleton interactions, the linkage between the cytoplasmic domain of band 3 (cdb3) and adducin has also been shown to be critical to membrane integrity. In the present paper, we demonstrate that adducin, a major component of the spectrin-actin junctional complex, binds primarily to residues 246-264 of cdb3, and mutation of two exposed glutamic acid residues within this sequence completely abrogates both α- and β-adducin binding...
October 1, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27349000/alpha-adducin-g460t-variant-is-a-risk-factor-for-hypertension-in-tunisian-population
#18
Hayet Soualmia, Abir Ben Romdhane, Fatma Midani, Amani Kallel, Riadh Jemaa, Moncef Feki, Naziha Kaabachi
BACKGROUND: Adducin is a membrane cytoskeletal protein, consisting of three subunits: α, β, and γ subunits encoded by three different genes (ADD1, ADD2, ADD3). A specific mutation G460T of the α-adducin gene (ADD1) is associated with high renal tubular sodium reabsorption. This mutation is associated with salt sensitivity and may influence the risk of hypertension. In this study, we investigated the relationship between the G460T polymorphism of the ADD1 and essential hypertension (EH) in the Tunisian population...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/27340988/angiotensin-converting-enzyme-ace-i-d-and-alpha-adducin-add1-g460w-gene-polymorphisms-in-turkish-patients-with-severe-chronic-tinnitus
#19
Salim Yuce, Enver Sancakdar, Gokhan Bağcı, Sema Koc, Hande Kucuk Kurtulgan, Binnur Bağcı, Mansur Doğan, İsmail Onder Uysal
OBJECTIVE: Tinnitus is described as a disturbing sound sensation in the absence of external stimulation. We aimed to investigate whether there is any relationship between severe chronic tinnitus and angiotensin-converting enzyme (ACE) I/D and α-adducin (ADD1) G460W gene polymorphisms. MATERIALS AND METHODS: The patient group and control group consisted of 89 and 104 individuals, respectively. The evaluation of tinnitus was performed using the Strukturiertes Tinnitus-Interview (STI)...
April 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27326240/impact-of-interactions-between-risk-alleles-on-clinical-endpoints-in-hypertension
#20
Samantha Kohli, Rahul Kumar, Mohit Gupta, Sanjay Tyagi, M A Qadar Pasha
OBJECTIVE: Impairment of the renin-angiotensinogen-aldosterone system (RAAS), one of the characteristics of essential hypertension (EH), imbalances vascular homeostasis. Despite inconsistent reports on individual single nucleotide polymorphisms (SNPs) as a major predictor of EH, interactions among RAAS genetic variants are rarely investigated. METHODS: Using SNP markers, we studied potential interactions between angiotensin 1 converting enzyme (ACE), angiotensinogen (AGT), angiotensin II-type 1 receptor (AGTR1), and α adducin (ADD1) variants and their correlation with clinical endpoints in 545 individuals with hypertension and 400 age- and ethnicity-matched unrelated controls...
2016: Heart Asia
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