keyword
https://read.qxmd.com/read/38524729/telitacicept-treatment-refractory-lupus-nephritis-a-case-report
#21
Sijia Li, Shuting Deng, Sichun Wen, Siqi Peng, Nan Jiang, Bohou Li, Boxi Chen, Ye Yuan, Qiong Wu, Yiming Tao, Jianchao Ma, Ting Lin, Feng Wen, Zhuo Li, Hao Dai, Renwei Huang, Zhonglin Feng, Zhilian Li, Shuangxin Liu, Lixia Xu
INTRODUCTION: Refractory lupus nephritis (LN) causes kidney disease progression and increases the risk of loss of renal function. Due to the high specificity and few side effects of biological agents, they are recommended for the treatment of systemic lupus erythematosus. There are few data on telitacicept for the treatment of refractory LN. CASE PRESENTATION: Here, we report the efficacy and safety of telitacicept in the treatment of refractory LN in a 25-year-old female patient...
2024: Case Reports in Nephrology and Dialysis
https://read.qxmd.com/read/38524503/perioperative-and-long-term-results-of-ultrasonography-guided-single-and-multiple-tract-percutaneous-nephrolithotomy-for-staghorn-calculi
#22
JOURNAL ARTICLE
Rui-Xiang Cheng, Ni Dai, Yan-Min Wang, Pei Qi, Fen Chen
BACKGROUND: It is possible that this condition will lead to urosepsis and progressive deterioration of renal function in the absence of surgical intervention. Several recent clinical studies have shown that multi-tract percutaneous nephrolithotomy (M-PCNL) has a similar stone free rate (SFR) as standard percutaneous nephrolithotomy (S-PCNL). As a result, M-PCNL was also recommended as a treatment option for staghorn calculi. AIM: To examine the perioperative and long-term results of ultrasonography-guided single- and M-PCNL...
March 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38523672/the-key-mediator-of-diabetic-kidney-disease-potassium-channel-dysfunction
#23
REVIEW
Jia Guo, Chaojie Zhang, Hui Zhao, Yufan Yan, Zhangsuo Liu
Diabetic kidney disease is a leading cause of end-stage renal disease, making it a global public health concern. The molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex pathogenesis. Thus, exploring these mechanisms from new perspectives is the current focus of research concerning diabetic kidney disease. Ion channels are important proteins that maintain the physiological functions of cells and organs. Among ion channels, potassium channels stand out, because they are the most common and important channels on eukaryotic cell surfaces and function as the basis for cell excitability...
July 2024: Genes & Diseases
https://read.qxmd.com/read/38523633/arachidonic-acid-metabolism-as-a-therapeutic-target-in-aki-to-ckd-transition
#24
REVIEW
Xiao-Jun Li, Ping Suo, Yan-Ni Wang, Liang Zou, Xiao-Li Nie, Ying-Yong Zhao, Hua Miao
Arachidonic acid (AA) is a main component of cell membrane lipids. AA is mainly metabolized by three enzymes: cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP450). Esterified AA is hydrolysed by phospholipase A2 into a free form that is further metabolized by COX, LOX and CYP450 to a wide range of bioactive mediators, including prostaglandins, lipoxins, thromboxanes, leukotrienes, hydroxyeicosatetraenoic acids and epoxyeicosatrienoic acids. Increased mitochondrial oxidative stress is considered to be a central mechanism in the pathophysiology of the kidney...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38523631/jian-pi-gu-shen-hua-yu-decoction-alleviated-diabetic-nephropathy-in-mice-through-reducing-ferroptosis
#25
JOURNAL ARTICLE
Shuquan Lv, Lirong Fan, Xiaoting Chen, Xiuhai Su, Li Dong, Qinghai Wang, Yuansong Wang, Hui Zhang, Huantian Cui, Shufang Zhang, Lixin Wang
BACKGROUND: Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment of chronic kidney diseases such as DN, but the specific mechanism of action has not been fully elucidated yet. PURPOSE: The aim of this study is to clarify whether JPGS alleviates the progression of diabetic nephropathy by inhibiting ferroptosis...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38523030/advancing-immunosuppression-in-liver-transplantation-a-narrative-review
#26
REVIEW
Samuele Iesari, Francesca Laura Nava, Ilaria Elena Zais, Laurent Coubeau, Mariano Ferraresso, Evaldo Favi, Jan Lerut
Immunosuppression is essential to ensure recipient and graft survivals after liver transplantation (LT). However, our understanding and management of the immune system remain suboptimal. Current immunosuppressive therapy cannot selectively inhibit the graft-specific immune response and entails a significant risk of serious side effects, i.e., among others, de novo cancers, infections, cardiovascular events, renal failure, metabolic syndrome, and late graft fibrosis, with progressive loss of graft function. Pharmacological research, aimed to develop alternative immunosuppressive agents in LT, is behind other solid-organ transplantation subspecialties, and, therefore, the development of new compounds and strategies should get priority in LT...
March 16, 2024: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://read.qxmd.com/read/38520226/lncrna-aa465934-improves-podocyte-injury-by-promoting-tristetraprolin-mediated-hmgb1-downregulation-in-diabetic-nephropathy
#27
JOURNAL ARTICLE
Nan Yang, Yue Zhang, Peiyao Ren, Li Zhao, Danna Zheng, Lanjun Fu, Juan Jin
Although LncRNA AA465934 expression is reduced in high glucose (HG)-treated podocytes, its role in HG-mediated podocyte injury and diabetic nephropathy (DN) remains unknown. Herein, we investigated the role of AA465934 in HG-mediated podocyte injury and DN using a spontaneous type II diabetic nephropathy (T2DN) model. The model was created by injecting AA465934 overexpressed adeno-associated virus (AAV) or control into mice. The levels of renal function, proteinuria, renal structural lesions, and podocyte apoptosis were then examined...
March 23, 2024: Molecular and Cellular Biology
https://read.qxmd.com/read/38517387/identification-and-validation-of-a-novel-signature-based-on-macrophage-marker-genes-for-predicting-prognosis-and-drug-response-in-kidney-renal-clear-cell-carcinoma-by-integrated-analysis-of-single-cell-and-bulk-rna-sequencing
#28
JOURNAL ARTICLE
Xiaoxu Chen, Zheyu Zhang, Zheng Qin, Xiao Zhu, Kaibin Wang, Lijuan Kang, Changying Li, Haitao Wang
Macrophages are found in a variety of tumors and play a critical role in shaping the tumor microenvironment, affecting tumor progression, metastasis, and drug resistance. However, the clinical relevance of marker genes associated with macrophage in kidney renal clear cell carcinoma (KIRC) has yet to be documented. In this study, we initiated a thorough examination of single-cell RNA sequencing (scRNA-seq) data for KIRC retrieved from the Gene Expression Omnibus (GEO) database and determined 244 macrophage marker genes (MMGs)...
March 20, 2024: Aging
https://read.qxmd.com/read/38517337/sodium-glucose-cotransporter-2-inhibitors-are-they-ready-for-prime-time-in-the-management-of-lupus-nephritis
#29
JOURNAL ARTICLE
Benjamin R Wagner, Panduranga S Rao
PURPOSE OF REVIEW: Lupus nephritis is a common complication of systemic lupus erythematosus and is associated with significant morbidity and mortality. The utility of sodium-glucose cotransporter 2 (SGLT2) inhibitors in the management of lupus nephritis is currently uncertain. Here, we summarize the rationale for their use among patient with lupus nephritis. RECENT FINDINGS: SGLT2 inhibitors were initially developed as antihyperglycemic agents. They have since been shown to have additional, profound effects to slow the progression of chronic kidney disease and lessen the long-term risks of cardiovascular disease in large clinic trials of patients with chronic kidney disease, with and without diabetes, as well as in patients with and without proteinuria...
May 1, 2024: Current Opinion in Rheumatology
https://read.qxmd.com/read/38516874/the-potential-for-improved-outcomes-in-the-prevention-and-therapy-of-diabetic-kidney-disease-through-stacking-of-drugs-from-different-classes
#30
REVIEW
David S H Bell, Terri Jerkins
Aggressive therapy of diabetic kidney disease (DKD) can not only slow the progression of DKD to renal failure but, if utilized at an early enough stage of DKD, can also stabilize and/or reverse the decline in renal function. The currently recognized standard of therapy for DKD is blockade of the renin-angiotensin system with angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs). However, unless utilized at a very early stage, monotherapy with these drugs in DKD will only prevent or slow the progression of DKD and will neither stabilize nor reverse the progression of DKD to renal decompensation...
March 22, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38516776/circular-rnas-and-the-regulation-of-gene-expression-in-diabetic-nephropathy-review
#31
JOURNAL ARTICLE
Maximo Berto Martinez Benitez, Yussel Pérez Navarro, Elisa Azuara-Liceaga, Angeles Tecalco Cruz, Jesús Valdés Flores, Lilia Lopez-Canovas
Circular RNAs (circRNAs) are non‑coding single‑stranded covalently closed RNA molecules that are considered important as regulators of gene expression at the transcriptional and post‑transcriptional levels. These molecules have been implicated in the initiation and progression of multiple human diseases, ranging from cancer to inflammatory and metabolic diseases, including diabetes mellitus and its vascular complications. The present article aimed to review the current knowledge on the biogenesis and functions of circRNAs, as well as their role in cell processes associated with diabetic nephropathy...
May 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38513825/change-over-time-in-pre-esrd-24-hour-urine-creatinine-as-muscle-mass-surrogate-and-post-esrd-mortality
#32
JOURNAL ARTICLE
Sahar Amin, Barry M Wall, Fridtjof Thomas, Kamyar Kalantar-Zadeh, Keiichi Sumida, Csaba P Kovesdy
OBJECTIVE: Loss of muscle mass and sarcopenia are common in CKD and ESRD, and sarcopenia can worsen insidiously in patients with advancing CKD. The temporal dynamics of sarcopenia in patients with progressive loss of kidney function, and its association with future outcomes, is unclear. METHODS: In a contemporary national cohort of incident ESRD US veterans, we selected 661 patients who had at least two 24-hour urine creatinine (24hrUC) measurements, a surrogate of muscle mass, performed during the 3-year prelude period prior to ESRD transition...
March 19, 2024: Journal of Renal Nutrition
https://read.qxmd.com/read/38513628/nephrolithiasis-associated-to-nephrocalcinosis-is-primarily-composed-of-carbonate-apatite
#33
JOURNAL ARTICLE
Teresa Antonia Kiener, Elena Moré, Michael Franzen, Janne Cadamuro, Christoph Schwarz, Carsten Bergmann, Hermann Salmhofer
INTRODUCTION: This study was designed to determine the mineral composition of calculi in nephrocalcinosis with nephrolithiasis, diagnose the underlying disease and monitor the course of renal function in patients with nephrocalcinosis-nephrolithiasis. METHODS: Renal calculi extruded in a series of eight patients with nephrocalcinosis were analysed using Fourier transmission infrared spectrometry. In four patients, next generation sequencing (NGS) using a nephrocalcinosis-nephrolithiasis panel was performed to determine the nature of the underlying disease...
March 21, 2024: Kidney & Blood Pressure Research
https://read.qxmd.com/read/38512446/sleeve-gastrectomy-links-the-attenuation-of-diabetic-kidney-disease-to-the-inhibition-of-renal-tubular-ferroptosis-through-down-regulating-tgf-%C3%AE-1-smad3-signaling-pathway
#34
JOURNAL ARTICLE
C Liu, M Zhong, X Jin, J Zhu, Y Cheng, L Li, Q Xu, Q Liu, H Ding, G Zhang
PURPOSE: To investigate how sleeve gastrectomy (SG), a typical operation of bariatric surgery, attenuated symptom, and progression of diabetic kidney disease (DKD). METHODS: DKD model was induced by high-fat diet (HFD) combined with streptozocin in Wistar rats. SG was performed, and the group subjected to sham surgery served as control. The animals were euthanized 12 weeks after surgery, followed by sample collection for the subsequent experiment. The HK-2, a renal proximal tubular epithelial cell line derived from human, was utilized to investigate the potential mechanisms...
March 21, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38511865/renal-hemodynamic-and-functional-changes-in-adpkd-patients
#35
JOURNAL ARTICLE
Ryota Ishii, Hirayasu Kai, Kentaro Nakajima, Takuya Harada, Tomoki Akiyama, Eri Okada, Ryoya Tsunoda, Toshiaki Usui, Kaori Mase, Naoki Morito, Chie Saito, Joichi Usui, Kunihiro Yamagata
BACKGROUND: Although the mechanisms underlying cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) are becoming clearer, those of renal dysfunction are not fully understood. In particular, total kidney volume (TKV) and renal function do not always correspond. To elucidate this discrepancy, we studied in detail glomerular hemodynamic changes during ADPKD progression. METHODS: Sixty-one ADPKD patients with baseline height-adjusted TKV (Ht-TKV) of 933±537 ml/m and serum creatinine of 1...
March 21, 2024: Kidney360
https://read.qxmd.com/read/38510995/clinical-course-of-adults-with-co-occurring-hypertrophic-cardiomyopathy-and-hypertension-a-scoping-review
#36
REVIEW
Milla Arabadjian, Sophie Montgomery, Mitchell Pleasure, Barnaby Nicolas, Maxine Collins, Maria Reuter, Daniele Massera, Daichi Shimbo, Mark V Sherrid
INTRODUCTION: Hypertension affects approximately 50 % of patients with hypertrophic cardiomyopathy (HCM) but clinical course in adults with co-occurring HCM and hypertension is underexplored. Management may be challenging as routine anti-hypertensive medications may worsen obstructive HCM, the most common HCM phenotype. In this scoping review, we sought to synthesize the available literature related to clinical course and outcomes in adults with both conditions and to highlight knowledge gaps to inform future research directions...
March 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510889/acute-pyelonephritis-and-an-incidental-diagnosis
#37
Inês Santos, Maria I Simão, Maria J Lúcio, Miguel O Santos, Guilherme Sacramento, Catarina I Cabral, Joana Vaz
Gastrointestinal stromal tumors (GISTs) arise from the gastrointestinal tract. In rare cases, extra-gastrointestinal stromal tumors (EGISTs) occur in the omentum, mesentery, et cetera. They are mostly asymptomatic or have unspecific symptoms. Risk stratification classification systems are based on tumor size, mitotic rate, location, and perforation. The gold standard for diagnosis is a computed tomography (CT) scan. Ultrasound/CT-guided percutaneous biopsy allows histopathology and immunochemistry results (most stain positive for CD117 (c-KIT), CD34, and/or DOG1)...
February 2024: Curēus
https://read.qxmd.com/read/38509909/c-type-lectin-2d-clec2d-is-upregulated-in-clear-cell-renal-cell-carcinoma-ccrcc-tissues-and-predicts-poor-prognosis
#38
JOURNAL ARTICLE
Huibing Li, Pengyi Zheng, Zhijun Li, Qingjiang Han, Bisheng Zhou, Kaixuan Wang
Clear cell renal cell carcinoma (ccRCC) is known as the most common type of renal cancer. Recently, a series of advances have been made in targeted therapy for ccRCC. To combat this highly metastatic tumor, novel therapeutic targets still need to be developed. C-type lectins (CLECs) contain a characteristic C-type lectin-like domain and affect several physiological functions. The effects of C-type lectin 2D (CLEC2D) on cancer progression have been revealed in several types of cancers; however, its expression in ccRCC tissues, and the possible effects on the progression and metastasis of ccRCC, are still unclear...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38509588/sglt2-inhibition-high-density-lipoprotein-and-kidney-function-a-mendelian-randomization-study
#39
JOURNAL ARTICLE
Zhijuan Wang, Jie Wei, Wenman Zhao, Rui Shi, Yuyu Zhu, Xunliang Li, Deguang Wang
BACKGROUND: Sodium-glucose cotransporter 2 (SGLT2) inhibition is recognized for its evident renoprotective benefits in diabetic renal disease. Recent data suggest that SGLT2 inhibition also slows down kidney disease progression and reduces the risk of acute kidney injury, regardless of whether the patient has diabetes or not, but the mechanism behind these observed effects remains elusive. The objective of this study is to utilize a mendelian randomization (MR) methodology to comprehensively examine the influence of metabolites in circulation regarding the impact of SGLT2 inhibition on kidney function...
March 20, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38509389/impact-of-bk-polyomavirus-viremia-on-the-outcomes-of-allogeneic-hematopoietic-stem-cell-transplantation
#40
JOURNAL ARTICLE
Yoshihiro Umezawa, Kota Yoshifuji, Keisuke Tanaka, Ayako Nogami, Katsutoshi Nagano, Ayako Tsuji, Toshikage Nagao, Masahide Yamamoto, Michiko Kajiwara, Shuji Tohda, Takehiko Mori
Although it is known that BK polyomavirus (BKPyV) causes hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT), the clinical significance of BKPyV viremia has not been fully evaluated. We retrospectively analyzed the results of quantitative polymerase chain reaction (PCR) evaluations for detecting BKPyV in the whole blood samples of patients undergoing allogeneic HSCT during the period from January 2010 to June 2020 at a single institute, Tokyo Medical and Dental University...
March 21, 2024: Annals of Hematology
keyword
keyword
43738
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.