Kelly A Moore, Kayla M Pate, Deborah D Soto-Ortega, Samuel Lohse, Nicholas van der Munnik, Mihyun Lim, Kaliah S Jackson, Venetia D Lyles, Lemeisha Jones, Nisha Glassgow, Vanessa M Napumecheno, Shanee Mobley, Mark J Uline, Rahina Mahtab, Catherine J Murphy, Melissa A Moss
BACKGROUND: Deposits of aggregated amyloid-β protein (Aβ) are a pathological hallmark of Alzheimer's disease (AD). Thus, one therapeutic strategy is to eliminate these deposits by halting Aβ aggregation. While a variety of possible aggregation inhibitors have been explored, only nanoparticles (NPs) exhibit promise at low substoichiometric ratios. With tunable size, shape, and surface properties, NPs present an ideal platform for rationally designed Aβ aggregation inhibitors. In this study, we characterized the inhibitory capabilities of gold nanospheres exhibiting different surface coatings and diameters...
2017: Journal of Biological Engineering