keyword
https://read.qxmd.com/read/22409425/matrix-metalloprotease-2-responsive-multifunctional-liposomal-nanocarrier-for-enhanced-tumor-targeting
#21
JOURNAL ARTICLE
Lin Zhu, Pooja Kate, Vladimir P Torchilin
A novel "smart" multifunctional drug delivery system was successfully developed to respond to the up-regulated matrix metalloprotease 2 (MMP2) in the tumor microenvironment and improve cancer cell-specific delivery of loaded drugs. The system represents a surface-functionalized liposomal nanocarrier, for which two functional polyethylene glycol (PEG)-lipid conjugates were synthesized and characterized. The functionalized liposome was further modified with the tumor cell-specific antinucleosome monoclonal antibody (mAb 2C5)...
April 24, 2012: ACS Nano
https://read.qxmd.com/read/22207249/chilblain-lupus-induced-by-tnf-%C3%AE-antagonists-a-case-report-and-literature-review
#22
REVIEW
Walter A Sifuentes Giraldo, María Ahijón Lana, María Jesús García Villanueva, Carmen González García, Mónica Vázquez Diaz
We report the case of a 72-year-old man with history of ankylosing spondylitis, who, during the treatment with infliximab, developed painful, erythematous-violaceous plaques with later development of ulcers on his feet associated with cold exposure. Concomitantly with the appearance of these lesions, he presented increased antinuclear antibodies (ANA) titers, positivity for anti-DNA and IgM anticardiolipin antibodies, low complement levels, polyclonal hypergammaglobulinemia, and lymphopenia. He was diagnosed of chilblain lupus induced by infliximab, this agent was withdrawn and initiated treatment for chilblains with improvement of lesions...
March 2012: Clinical Rheumatology
https://read.qxmd.com/read/22089161/antinucleosome-in-systemic-lupus-erythematosus-a-study-in-a-brazilian-population
#23
JOURNAL ARTICLE
G A Sardeto, L M Simas, T S Skare, R M Nisihara, S R R Utiyama
Antinucleosome antibodies have been found with variable prevalence in systemic lupus erythematosus (SLE) and were associated with more severe disease. This research aims to study the prevalence of antinucleosome antibodies in a sample of Brazilian adult SLE patients and their association with clinical findings and disease activity. Ninety-two adult patients (81 females and 11 males, with mean age of 37.29 ± 10.98 years) with SLE were studied for clinical and antibody profile, disease activity by SLE disease activity index (SLEDAI), and presence of antinucleosome antibodies by ELISA...
March 2012: Clinical Rheumatology
https://read.qxmd.com/read/22001720/pretargeted-gamma-imaging-of-murine-metastatic-melanoma-lung-lesions-with-bispecific-antibody-and-radiolabeled-polymer-drug-conjugates
#24
JOURNAL ARTICLE
Keyur S Gada, Vishwesh Patil, Rajiv Panwar, Stan Majewski, Yared Tekabe, Ban-An Khaw
INTRODUCTION: Bispecific monoclonal antibodies (bsMAbs) have been developed as a pretargeting tool to reduce background activity, thereby increasing target to background (T : B) ratios. To enhance visualization of small lesions in vivo, we have used the pretargeting approach of bsMAb and negatively charged polymers radiolabeled with high-specific radioactivity. METHODS: Imaging of metastatic melanoma lesions localized in lung tissues pretargeted with bsMAb and targeted with high-specific radioactivity polymers was carried out...
December 2011: Nuclear Medicine Communications
https://read.qxmd.com/read/21946514/antinucleosome-antibodies-as-a-potential-biomarker-for-the-evaluation-of-renal-pathological-activity-in-patients-with-proliferative-lupus-nephritis
#25
JOURNAL ARTICLE
W T Hung, Y M Chen, J L Lan, H H Chen, Y H Chen, D Y Chen, C W Hsieh, M C Wen
The objective of this study is to evaluate the correlation between antinucleosome antibodies and renal pathological activity in patients with proliferative lupus nephritis (LN). We evaluated 36 patients with proliferative LN, 14 non-renal lupus patients and 10 healthy volunteers. Lupus activity was assessed using the British Isles Lupus Assessment Group 2004 (BILAG 2004) index, serum anti-double stranded DNA (anti-dsDNA) levels, serum complement levels and daily urinary protein levels. All 36 lupus nephritis patients received renal biopsy...
November 2011: Lupus
https://read.qxmd.com/read/21914852/evolutionary-divergence-of-intrinsic-and-trans-regulated-nucleosome-positioning-sequences-reveals-plastic-rules-for-chromatin-organization
#26
JOURNAL ARTICLE
Alex Tsankov, Yoshimi Yanagisawa, Nicholas Rhind, Aviv Regev, Oliver J Rando
The packaging of eukaryotic genomes into nuclesomes plays critical roles in chromatin organization and gene regulation. Studies in Saccharomyces cerevisiae indicate that nucleosome occupancy is partially encoded by intrinsic antinucleosomal DNA sequences, such as poly(A) sequences, as well as by binding sites for trans-acting factors that can evict nucleosomes, such as Reb1 and the Rsc3/30 complex. Here, we use genome-wide nucleosome occupancy maps in 13 Ascomycota fungi to discover large-scale evolutionary reprogramming of both intrinsic and trans determinants of chromatin structure...
November 2011: Genome Research
https://read.qxmd.com/read/21875377/distinctive-autoantibody-profile-in-mexican-mestizo-systemic-sclerosis-patients
#27
COMPARATIVE STUDY
Tatiana S Rodriguez-Reyna, Andrea Hinojosa-Azaola, Cynthia Martinez-Reyes, Carlos A Nuñez-Alvarez, Rocío Torrico-Lavayen, José Luis García-Hernández, Javier Cabiedes-Contreras
Systemic sclerosis (SSc) shows variable clinical expression among different ethnic groups. Herein, we describe the clinical features, prevalence of organ involvement, and autoantibody profile in Mexican Mestizo SSc patients and we compare them with patients from other ethnic groups.We included 139 SSc patients. They underwent clinical evaluation and were tested for antinuclear antibodies (ANA), anticentromere antibodies (ACA), anti-topoisomerase I, anti-RNA polymerase III, anti-U1 RNP, anti-U3 RNP, anti-U11/U12 RNP, anti-Th/To, anti-PM-Scl, anti-Ku, antinucleosome, anti-double-stranded DNA (dsDNA), anti-Sm, anti-SSA, and anti-SSB antibodies...
November 2011: Autoimmunity
https://read.qxmd.com/read/21870873/development-of-the-novel-peg-pe-based-polymer-for-the-reversible-attachment-of-specific-ligands-to-liposomes-synthesis-and-in-vitro-characterization
#28
JOURNAL ARTICLE
Swati Biswas, Namita S Dodwadkar, Rupa R Sawant, Vladimir P Torchilin
Surface grafting of liposomes with the wide variety of ligands including antibodies and other proteins is a promising approach for targeted delivery of therapeutics. In this paper, we describe a simple method of synthesizing a hydrazine-functionalized poly(ethylene glycol)-phosphatidylethanolamine (PEG-PE)-based amphiphilic polymer which can conjugate a variety of ligands via a reversible, pH-cleavable bond. In this method, the targeting ligand is attached to the distal end of the PEG chain, which facilitates its easy access to the targeted site of interaction...
October 19, 2011: Bioconjugate Chemistry
https://read.qxmd.com/read/21839371/lupus-nephritis-role-of-antinucleosome-autoantibodies
#29
REVIEW
Johan van der Vlag, Jo H M Berden
The discovery of autoantigen clustering in blebs at the surface of apoptotic cells boosted research on the role of apoptosis in systemic lupus erythematosus (SLE) and led to the discovery of autoantigen modification during apoptosis. Normally, apoptotic cells are cleared efficiently and swiftly. However, it became clear that in SLE insufficient removal of apoptotic material leads to the release of these modified autoantigens. This creates the danger that these modified autoantigens are recognized by the immune system...
July 2011: Seminars in Nephrology
https://read.qxmd.com/read/21831149/eculizumab-in-acute-recurrence-of-thrombotic-microangiopathy-after-renal-transplantation
#30
JOURNAL ARTICLE
K Hadaya, S Ferrari-Lacraz, D Fumeaux, F Boehlen, C Toso, S Moll, P-Y Martin, J Villard
Renal thrombotic microangiopathy (TMA) is a severe complication of systemic lupus erythematosus (SLE), which is associated with the presence of antiphospholipid (aPL) antibodies. In its most fulminant form, TMA leads to a rapid and irreversible end-stage renal failure. Eculizumab, an anti-C5 monoclonal antibody, is a novel therapy of choice for patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome. Here, we report the case of a 27-year-old woman, known for SLE and end-stage renal disease due to fulminant TMA...
November 2011: American Journal of Transplantation
https://read.qxmd.com/read/21329504/anti-dsdna-ncx-elisa-dsdna-loaded-nucleosomes-improve-diagnosis-and-monitoring-of-disease-activity-in-systemic-lupus-erythematosus
#31
JOURNAL ARTICLE
Robert Biesen, Cornelia Dähnrich, Anke Rosemann, Fidan Barkhudarova, Thomas Rose, Olga Jakob, Anne Bruns, Marina Backhaus, Winfried Stöcker, Gerd-Rüdiger Burmester, Wolfgang Schlumberger, Karl Egerer, Falk Hiepe
INTRODUCTION: The objective of this study was to compare the clinical usefulness of the new anti-double-stranded DNA nucleosome-complexed enzyme-linked immunosorbent assay (Anti-dsDNA-NcX ELISA), which is based on dsDNA-loaded nucleosomes as antigens, with established test systems based on dsDNA or nucleosomes alone for systemic lupus erythematosus (SLE) diagnostics and determination of disease activity. METHODS: Sera from a cohort of 964 individuals comprising 207 SLE patients, 357 disease controls and 400 healthy donors were investigated using the Anti-dsDNA-NcX ELISA, Farr assay, Anti-dsDNA ELISA, Anti-nucleosome ELISA and Crithidia luciliae immunofluorescence (CLIF) assay, all of which are tests available from EUROIMMUN Medizinische Labordiagnostika AG (Lübeck, Germany)...
2011: Arthritis Research & Therapy
https://read.qxmd.com/read/21078493/performance-of-anti-c1q-antinucleosome-and-anti-dsdna-antibodies-for-detecting-concurrent-disease-activity-of-systemic-lupus-erythematosus
#32
JOURNAL ARTICLE
Chi Chiu Mok, Ling Yin Ho, Hoi Wah Leung, Lap Gate Wong
The objective of this study is to evaluate the specificity and sensitivity of antinucleosome, anti-C1q, and anti-dsDNA antibodies for detecting concurrent disease activity in systemic lupus erythematosus (SLE). Consecutive patients were recruited for serological testing of anti-dsDNA, IgG-antinucleosome, IgG-anti-C1q, and complement levels. SLE disease activity was assessed by SLEDAI and physician's global assessment (PGA). The levels of these antibodies, complements, and disease activity scores were correlated...
December 2010: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/20477165/the-use-of-laboratory-methods-in-differential-diagnosis-and-treatment-of-sle-and-antiphospholipid-syndrome
#33
JOURNAL ARTICLE
Paula Alba, Maria Laura Bertolaccini, Munther A Khamashta
The detection of autoantibodies has become an important component in the diagnosis and management of systemic lupus erythematosus (SLE) and antiphospholipid syndrome. Their importance lies in the fact that they are not only markers of the disease and used as part of a diagnostic panel, but many of them also show correlation with disease activity. All antibody testing should be interpreted in the context of the clinical features. The antinuclear antibodies test is an effective screening assay in patients with clinical features of SLE...
July 2007: Expert Review of Clinical Immunology
https://read.qxmd.com/read/20477142/clinical-importance-of-autoantibodies-in-lupus-nephritis
#34
JOURNAL ARTICLE
Mohammed Yousuf Karim, Patrick Fk Yong, David P D'Cruz
Renal involvement is a serious clinical feature of systemic lupus erythematosus and can present at any stage of the disease. Although its treatment and outcome have improved, lupus nephritis is still a major contributor to morbidity. Autoantibodies, particularly those directed toward nuclear antigens, are a major feature of systemic lupus erythematosus. With respect to nephritis, there are several aspects of lupus autoantibodies that merit attention, including their use in diagnosis and monitoring, and their role in pathogenesis...
November 2007: Expert Review of Clinical Immunology
https://read.qxmd.com/read/19957531/-induction-of-oral-immune-tolerance-in-systemic-lupus-erythematosus-like-murine-model-by-recombinant-nucleosomal-universal-th-cell-epitope
#35
JOURNAL ARTICLE
Chun-Li Zhou, Jin Hao, Shu-Qian Tang, Bai-Yu Zhong, Fei Hao
OBJECTIVE: To explore the feasibility of oral immune tolerance of systemic lupus erythematosus (SLE)-like model induced by nucleosomal Th cell epitope via the attenuated Salmonella typhimurium. METHODS: SLE-like murine model was established by immunization with apoptotic syngeneic lymphocytes. The recombinant strains were orally administrated to induce immune tolerance. The levels of serum autoantibodies, such as anti-ANA, ds-DNA, and antinucleosome antibody, leukopenia, proteinuria and kidney injuries were evaluated...
June 23, 2009: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/19335730/up-regulation-of-cellular-flice-inhibitory-protein-in-peripheral-blood-b-lymphocytes-in-patients-with-systemic-lupus-erythematosus-is-associated-with-clinical-characteristics
#36
JOURNAL ARTICLE
J Tao, J Dong, Y Li, Y-Q Liu, J Yang, Y Wu, L Li, G-X Shen, Z-J Tan, Y-T Tu
BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disease which is involved in T- and B-lymphocyte-mediated autoimmunity. Apoptosis contributes to the maintenance of lymphocytes homeostasis and the deletion of autoreactive cells in SLE. Although there is evidence that cellular FLICE-inhibitory protein (c-FLIP), an antiapoptosis protein, is increased in human lupus T cells to keep them from apoptosis, but the expression of apoptosis-regulatory protein c-FLIP in SLE B lymphocytes remains unknown...
April 2009: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/19296936/serologic-markers-of-autoimmunity-in-women-with-polycystic-ovary-syndrome
#37
JOURNAL ARTICLE
Katrin Hefler-Frischmuth, Katharina Walch, Wolfgang Huebl, Konstantin Baumuehlner, Clemens Tempfer, Lukas Hefler
OBJECTIVE: To evaluate whether women with the polycystic ovary syndrome (PCOS) have an increased rate of elevated serum levels of common autoimmunologic parameters. DESIGN: Prospective case-control study. SETTING: Academic research institution. PATIENT(S): One hundred nine women with PCOS and 109 age-matched healthy controls. INTERVENTION(S): Peripheral venous puncture, ultrasonography, questionnaire...
May 1, 2010: Fertility and Sterility
https://read.qxmd.com/read/19278337/innate-immune-signals-modulate-antiviral-and-polyreactive-antibody-responses-during-severe-respiratory-syncytial-virus-infection
#38
JOURNAL ARTICLE
Jennifer L Reed, Timothy P Welliver, Gary P Sims, Luann McKinney, Luis Velozo, Luis Avendano, Karen Hintz, Jayson Luma, Anthony J Coyle, Robert C Welliver
Antiviral antibody production during respiratory syncytial virus (RSV) infection in infants is poorly understood. To characterize local B lymphocyte responses, lung tissue and secretions from infants with RSV bronchiolitis were analyzed for innate B cell-stimulating factors and antiviral antibodies. In lung tissues of infants with fatal RSV bronchiolitis, CD20(+) lymphocytes and IgM-positive, IgG-positive, and IgA-positive plasma cells were prominent but CD4(+) T lymphocytes were not. Type I interferon-induced proteins and B cell tropic factors, including B cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL), were colocalized in infected epithelium...
April 15, 2009: Journal of Infectious Diseases
https://read.qxmd.com/read/18854879/-primary-antiphospholipid-syndrome-evolving-into-systemic-lupus-erythematosus-may-antinucleosome-antibodies-be-predictive
#39
JOURNAL ARTICLE
L Andreoli, F Pregnolato, R W Burlingame, V Fanelli, F Allegri, A Radice, C Corace, R A Sinico, A Tincani, P L Meroni
OBJECTIVE: It was reported by several groups that patients diagnosed as primary antiphospholipid syndrome (PAPS) had developed a full-blown systemic lupus erythematosus (SLE) even after many years of follow-up. Little is known about clinical and/or serological factors that may help predict such evolution. Antinucleosome antibodies (anti-NCS) were described to appear in early stages of SLE, in particular before anti-dsDNA antibodies. The aim of the study is to evaluate the prevalence of anti-NCS in a large cohort of PAPS patients...
July 2008: Reumatismo
https://read.qxmd.com/read/18785312/abnormal-antinuclear-antibody-titers-are-less-common-than-generally-assumed-in-established-cases-of-systemic-lupus-erythematosus
#40
JOURNAL ARTICLE
Christopher Sjöwall, Martin Sturm, Charlotte Dahle, Anders A Bengtsson, Andreas Jönsen, Gunnar Sturfelt, Thomas Skogh
OBJECTIVE: To evaluate antinuclear antibody (ANA) tests in established cases of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) by indirect immunofluorescence microscopy (F-ANA) and enzyme-immunoassays detecting antinucleosomal antibodies (ANSA-EIA). METHODS: Sera from 50 patients with SLE and 65 patients with RA were analyzed regarding abnormal concentrations of F-ANA (serum dilution>or=1:200=95th percentile among 300 healthy blood donors). The sera were also analyzed with 2 commercial ANSA-EIA kits...
October 2008: Journal of Rheumatology
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