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https://www.readbyqxmd.com/read/26573545/murine-and-human-lupus-nephritis-pathogenic-mechanisms-and-theoretical-strategies-for-therapy
#1
REVIEW
Hege Lynum Pedersen, Kjersti Daae Horvei, Dhivya Thiyagarajan, Natalya Seredkina, Ole Petter Rekvig
Lupus nephritis is one of the most serious manifestations of systemic lupus erythematosus, and represents one of the criteria implemented to classify systemic lupus erythematosus. Although studied for decades, no consensus has been reached related to the basic cellular, molecular, and immunologic mechanism(s) responsible for lupus nephritis. No causal treatments have been developed; therapy is approached mainly with nonspecific immunosuppressive medications. More detailed insight into disease mechanisms therefore is indispensable to develop new therapeutic strategies...
September 2015: Seminars in Nephrology
https://www.readbyqxmd.com/read/25233687/anti-dsdna-anti-nucleosome-and-anti-c1q-antibodies-as-disease-activity-markers-in-patients-with-systemic-lupus-erythematosus
#2
Valentina Zivković, Aleksandra Stanković, Tatjana Cvetković, Branka Mitić, Svetislav Kostić, Jovan Nedović, Bojana Stamenković
INTRODUCTION: In spite of the growing number of reports on the study of anti-nucleosome and anti-C1q antibodies, there are still controversies on their significance as disease activity markers in patients with systemic lupus erythematosus (SLE) and their use in everyday clinical practice. OBJECTIVE: Our aim was to assess the presence of anti-dsDNA, anti-nucleosome and anti-C1q antibodies in SLE patients, as well as to establish their sensitivity, specificity, positive and negative predictive value, and their correlation with SLE and lupus nephritis clinical activity...
July 2014: Srpski Arhiv za Celokupno Lekarstvo
https://www.readbyqxmd.com/read/24708718/serum-antinucleosome-specific-antibody-as-a-marker-of-autoimmunity-in-children-with-autism
#3
Laila Yousef AL-Ayadhi, Gehan Ahmed Mostafa
BACKGROUND: Increasing evidence of autoimmune phenomena in some individuals with autism could represent the presence of altered or inappropriate immune responses in this disorder. The role of the nucleosome in the induction of antibody response in some autoimmune-mediated tissue damage may provide novel targets for treatment. Due to the paucity of studies investigating the frequency of systemic auto-antibodies in autism, we are the first to investigate the frequency of antinucleosome-specific antibodies in a group of autistic children...
2014: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/24470458/review-antinucleosome-antibodies-a-critical-reflection-on-their-specificities-and-diagnostic-impact
#4
REVIEW
Ole Petter Rekvig, Johan van der Vlag, Natalya Seredkina
No abstract text is available yet for this article.
May 2014: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/23945845/intima-media-thickness-measurement-as-a-marker-of-subclinical-atherosclerosis-in-sle-patient
#5
Andrea Smrzova, Pavel Horak, Martina Skacelova, Zuzana Hermanova, Katerina Langova, Josef Zadrazil, Dalibor Novotny
AIM: Accelerated atherosclerosis in systemic lupus erythematosus (SLE) is an important cause of morbidity and mortality. The pathophysiology of accelerated atherosclerosis in SLE is mediated by factors such as inflammatory processes in the vascular wall, specific antibodies, dyslipoproteinemia, endothelial dysfunction and the high prevalence of traditional risk factors for cardiovascular diseases. In this context, we evaluated the clinical significance of ultrasound examination of the carotic arteries in the early diagnosis of atherosclerosis...
September 2014: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/23223693/antinucleosome-and-anti-c1q-antibodies-in-juvenile-systemic-lupus-erythematosus
#6
EDITORIAL
Paulo Louzada-Junior, Max Victor Carioca Freitas
No abstract text is available yet for this article.
December 2012: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/23102622/ph-sensitive-poly-histidine-peg-dspe-peg-co-polymer-micelles-for-cytosolic-drug-delivery
#7
Hong Wu, Lin Zhu, Vladimir P Torchilin
To introduce pH sensitivity into the DSPE-PEG-based micellar system and achieve the quick intracellular drug release in response to the acidity in endosomes, a mixed polymeric micelle was developed based on three grafted copolymers, including 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000(DSPE-PEG(2000)), antinucleosome antibody (mAb 2C5)-modified DSPE-PEG(3400) (DSPE-PEG(3400)-2C5), and poly(ethylene glycol)-coupled poly(L-histidine) (PHIS-PEG(2000)). The structure of PHIS-PEG(2000) was confirmed by (1)H NMR spectroscopy...
January 2013: Biomaterials
https://www.readbyqxmd.com/read/22641590/antinucleosome-antibodies-and-primary-antiphospholipid-syndrome-an-observational-study
#8
Alexandre Wagner Silva de Souza, Silene Peres Keusseyan, Neusa Pereira da Silva, Emilia Inoue Sato, Luis Eduardo Coelho Andrade
OBJECTIVE: To study the association of anti-nucleosome (anti-NCS) antibodies in primary antiphospholipid syndrome (APS) and the development of systemic lupus erythematosus (SLE) during follow-up. MATERIALS AND METHODS: Thirty-six women with primary APS were evaluated prospectively for clinical features of systemic autoimmune diseases and for the presence of antiphospholipid antibodies, antinuclear antibodies and anti-NCS/chromatin antibodies. RESULTS: After a mean follow-up period of 45...
May 2012: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/22409425/matrix-metalloprotease-2-responsive-multifunctional-liposomal-nanocarrier-for-enhanced-tumor-targeting
#9
Lin Zhu, Pooja Kate, Vladimir P Torchilin
A novel "smart" multifunctional drug delivery system was successfully developed to respond to the up-regulated matrix metalloprotease 2 (MMP2) in the tumor microenvironment and improve cancer cell-specific delivery of loaded drugs. The system represents a surface-functionalized liposomal nanocarrier, for which two functional polyethylene glycol (PEG)-lipid conjugates were synthesized and characterized. The functionalized liposome was further modified with the tumor cell-specific antinucleosome monoclonal antibody (mAb 2C5)...
April 24, 2012: ACS Nano
https://www.readbyqxmd.com/read/22207249/chilblain-lupus-induced-by-tnf-%C3%AE-antagonists-a-case-report-and-literature-review
#10
REVIEW
Walter A Sifuentes Giraldo, María Ahijón Lana, María Jesús García Villanueva, Carmen González García, Mónica Vázquez Diaz
We report the case of a 72-year-old man with history of ankylosing spondylitis, who, during the treatment with infliximab, developed painful, erythematous-violaceous plaques with later development of ulcers on his feet associated with cold exposure. Concomitantly with the appearance of these lesions, he presented increased antinuclear antibodies (ANA) titers, positivity for anti-DNA and IgM anticardiolipin antibodies, low complement levels, polyclonal hypergammaglobulinemia, and lymphopenia. He was diagnosed of chilblain lupus induced by infliximab, this agent was withdrawn and initiated treatment for chilblains with improvement of lesions...
March 2012: Clinical Rheumatology
https://www.readbyqxmd.com/read/22089161/antinucleosome-in-systemic-lupus-erythematosus-a-study-in-a-brazilian-population
#11
G A Sardeto, L M Simas, T S Skare, R M Nisihara, S R R Utiyama
Antinucleosome antibodies have been found with variable prevalence in systemic lupus erythematosus (SLE) and were associated with more severe disease. This research aims to study the prevalence of antinucleosome antibodies in a sample of Brazilian adult SLE patients and their association with clinical findings and disease activity. Ninety-two adult patients (81 females and 11 males, with mean age of 37.29 ± 10.98 years) with SLE were studied for clinical and antibody profile, disease activity by SLE disease activity index (SLEDAI), and presence of antinucleosome antibodies by ELISA...
March 2012: Clinical Rheumatology
https://www.readbyqxmd.com/read/22001720/pretargeted-gamma-imaging-of-murine-metastatic-melanoma-lung-lesions-with-bispecific-antibody-and-radiolabeled-polymer-drug-conjugates
#12
Keyur S Gada, Vishwesh Patil, Rajiv Panwar, Stan Majewski, Yared Tekabe, Ban-An Khaw
INTRODUCTION: Bispecific monoclonal antibodies (bsMAbs) have been developed as a pretargeting tool to reduce background activity, thereby increasing target to background (T : B) ratios. To enhance visualization of small lesions in vivo, we have used the pretargeting approach of bsMAb and negatively charged polymers radiolabeled with high-specific radioactivity. METHODS: Imaging of metastatic melanoma lesions localized in lung tissues pretargeted with bsMAb and targeted with high-specific radioactivity polymers was carried out...
December 2011: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/21946514/antinucleosome-antibodies-as-a-potential-biomarker-for-the-evaluation-of-renal-pathological-activity-in-patients-with-proliferative-lupus-nephritis
#13
W T Hung, Y M Chen, J L Lan, H H Chen, Y H Chen, D Y Chen, C W Hsieh, M C Wen
The objective of this study is to evaluate the correlation between antinucleosome antibodies and renal pathological activity in patients with proliferative lupus nephritis (LN). We evaluated 36 patients with proliferative LN, 14 non-renal lupus patients and 10 healthy volunteers. Lupus activity was assessed using the British Isles Lupus Assessment Group 2004 (BILAG 2004) index, serum anti-double stranded DNA (anti-dsDNA) levels, serum complement levels and daily urinary protein levels. All 36 lupus nephritis patients received renal biopsy...
November 2011: Lupus
https://www.readbyqxmd.com/read/21914852/evolutionary-divergence-of-intrinsic-and-trans-regulated-nucleosome-positioning-sequences-reveals-plastic-rules-for-chromatin-organization
#14
Alex Tsankov, Yoshimi Yanagisawa, Nicholas Rhind, Aviv Regev, Oliver J Rando
The packaging of eukaryotic genomes into nuclesomes plays critical roles in chromatin organization and gene regulation. Studies in Saccharomyces cerevisiae indicate that nucleosome occupancy is partially encoded by intrinsic antinucleosomal DNA sequences, such as poly(A) sequences, as well as by binding sites for trans-acting factors that can evict nucleosomes, such as Reb1 and the Rsc3/30 complex. Here, we use genome-wide nucleosome occupancy maps in 13 Ascomycota fungi to discover large-scale evolutionary reprogramming of both intrinsic and trans determinants of chromatin structure...
November 2011: Genome Research
https://www.readbyqxmd.com/read/21875377/distinctive-autoantibody-profile-in-mexican-mestizo-systemic-sclerosis-patients
#15
COMPARATIVE STUDY
Tatiana S Rodriguez-Reyna, Andrea Hinojosa-Azaola, Cynthia Martinez-Reyes, Carlos A Nuñez-Alvarez, Rocío Torrico-Lavayen, José Luis García-Hernández, Javier Cabiedes-Contreras
Systemic sclerosis (SSc) shows variable clinical expression among different ethnic groups. Herein, we describe the clinical features, prevalence of organ involvement, and autoantibody profile in Mexican Mestizo SSc patients and we compare them with patients from other ethnic groups.We included 139 SSc patients. They underwent clinical evaluation and were tested for antinuclear antibodies (ANA), anticentromere antibodies (ACA), anti-topoisomerase I, anti-RNA polymerase III, anti-U1 RNP, anti-U3 RNP, anti-U11/U12 RNP, anti-Th/To, anti-PM-Scl, anti-Ku, antinucleosome, anti-double-stranded DNA (dsDNA), anti-Sm, anti-SSA, and anti-SSB antibodies...
November 2011: Autoimmunity
https://www.readbyqxmd.com/read/21870873/development-of-the-novel-peg-pe-based-polymer-for-the-reversible-attachment-of-specific-ligands-to-liposomes-synthesis-and-in-vitro-characterization
#16
Swati Biswas, Namita S Dodwadkar, Rupa R Sawant, Vladimir P Torchilin
Surface grafting of liposomes with the wide variety of ligands including antibodies and other proteins is a promising approach for targeted delivery of therapeutics. In this paper, we describe a simple method of synthesizing a hydrazine-functionalized poly(ethylene glycol)-phosphatidylethanolamine (PEG-PE)-based amphiphilic polymer which can conjugate a variety of ligands via a reversible, pH-cleavable bond. In this method, the targeting ligand is attached to the distal end of the PEG chain, which facilitates its easy access to the targeted site of interaction...
October 19, 2011: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/21839371/lupus-nephritis-role-of-antinucleosome-autoantibodies
#17
REVIEW
Johan van der Vlag, Jo H M Berden
The discovery of autoantigen clustering in blebs at the surface of apoptotic cells boosted research on the role of apoptosis in systemic lupus erythematosus (SLE) and led to the discovery of autoantigen modification during apoptosis. Normally, apoptotic cells are cleared efficiently and swiftly. However, it became clear that in SLE insufficient removal of apoptotic material leads to the release of these modified autoantigens. This creates the danger that these modified autoantigens are recognized by the immune system...
July 2011: Seminars in Nephrology
https://www.readbyqxmd.com/read/21831149/eculizumab-in-acute-recurrence-of-thrombotic-microangiopathy-after-renal-transplantation
#18
K Hadaya, S Ferrari-Lacraz, D Fumeaux, F Boehlen, C Toso, S Moll, P-Y Martin, J Villard
Renal thrombotic microangiopathy (TMA) is a severe complication of systemic lupus erythematosus (SLE), which is associated with the presence of antiphospholipid (aPL) antibodies. In its most fulminant form, TMA leads to a rapid and irreversible end-stage renal failure. Eculizumab, an anti-C5 monoclonal antibody, is a novel therapy of choice for patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome. Here, we report the case of a 27-year-old woman, known for SLE and end-stage renal disease due to fulminant TMA...
November 2011: American Journal of Transplantation
https://www.readbyqxmd.com/read/21329504/anti-dsdna-ncx-elisa-dsdna-loaded-nucleosomes-improve-diagnosis-and-monitoring-of-disease-activity-in-systemic-lupus-erythematosus
#19
Robert Biesen, Cornelia Dähnrich, Anke Rosemann, Fidan Barkhudarova, Thomas Rose, Olga Jakob, Anne Bruns, Marina Backhaus, Winfried Stöcker, Gerd-Rüdiger Burmester, Wolfgang Schlumberger, Karl Egerer, Falk Hiepe
INTRODUCTION: The objective of this study was to compare the clinical usefulness of the new anti-double-stranded DNA nucleosome-complexed enzyme-linked immunosorbent assay (Anti-dsDNA-NcX ELISA), which is based on dsDNA-loaded nucleosomes as antigens, with established test systems based on dsDNA or nucleosomes alone for systemic lupus erythematosus (SLE) diagnostics and determination of disease activity. METHODS: Sera from a cohort of 964 individuals comprising 207 SLE patients, 357 disease controls and 400 healthy donors were investigated using the Anti-dsDNA-NcX ELISA, Farr assay, Anti-dsDNA ELISA, Anti-nucleosome ELISA and Crithidia luciliae immunofluorescence (CLIF) assay, all of which are tests available from EUROIMMUN Medizinische Labordiagnostika AG (Lübeck, Germany)...
2011: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/21078493/performance-of-anti-c1q-antinucleosome-and-anti-dsdna-antibodies-for-detecting-concurrent-disease-activity-of-systemic-lupus-erythematosus
#20
Chi Chiu Mok, Ling Yin Ho, Hoi Wah Leung, Lap Gate Wong
The objective of this study is to evaluate the specificity and sensitivity of antinucleosome, anti-C1q, and anti-dsDNA antibodies for detecting concurrent disease activity in systemic lupus erythematosus (SLE). Consecutive patients were recruited for serological testing of anti-dsDNA, IgG-antinucleosome, IgG-anti-C1q, and complement levels. SLE disease activity was assessed by SLEDAI and physician's global assessment (PGA). The levels of these antibodies, complements, and disease activity scores were correlated...
December 2010: Translational Research: the Journal of Laboratory and Clinical Medicine
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