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Paracetamol and G6PD

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https://www.readbyqxmd.com/read/24684729/glucose-6-phosphate-dehydrogenase-deficiency-an-unusual-cause-of-acute-jaundice-after-paracetamol-overdose
#1
Simon Phillpotts, Elliot Tash, Sambit Sen
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the commonest human enzyme defect causing haemolytic anaemia after exposure to specific triggers. Paracetamol-induced haemolysis in G6PD deficiency is a rare complication and mostly reported in children. We report the first case (to the best of our knowledge) of acute jaundice without overt clinical features of a haemolytic crisis, in an otherwise healthy adult female following paracetamol overdose, due to previously undiagnosed G6PD deficiency. It is important that clinicians consider this condition when a patient presents following a paracetamol overdose with significant and disproportionate jaundice, without transaminitis or coagulopathy...
November 2014: European Journal of Haematology
https://www.readbyqxmd.com/read/21784438/potential-risks-of-hemolysis-after-short-term-administration-of-analgesics-in-children-with-glucose-6-phosphate-dehydrogenase-deficiency
#2
Nadia Najafi, Anne Van de Velde, Jan Poelaert
OBJECTIVE: To evaluate the risk of hemolysis in children with glucose-6-phosphate dehydrogenase (G6PD) deficiency after short-term administration of analgesics, such as paracetamol, ibuprofen, tramadol, sufentanil, and parecoxib. STUDY DESIGN: This was a prospective study of children with G6PD deficiency who were treated with analgesics for 3 days after undergoing surgery. Hemoglobin (Hb) concentration, reticulocyte count, unconjugated bilirubin level, lactate dehydrogenase level, and the presence of Heinz bodies on blood smear microscopy were assessed at baseline and after analgesic treatment...
December 2011: Journal of Pediatrics
https://www.readbyqxmd.com/read/21441392/acute-haemolytic-crisis-due-to-concomitant-presence-of-infection-and-possible-altered-acetaminophen-catabolism-in-a-philipino-child-carrying-the-g6pd-vanua-lava-mutation
#3
Angelo Minucci, Daniele De Luca, Eleonora Torti, Paola Concolino, Palma Maurizi, Bruno Giardina, Cecilia Zuppi, Ettore Capoluongo
Glucose-6-phosphate dehydrogenase (G6PD), an X-linked hereditary deficiency, is the most common of all clinically significant enzyme defects. While many drugs are responsible for haemolytic anaemia in G6PD-deficient patients, acetaminophen's imputability is still under debate, although an overdose of this drug can provoke acute haemolytic events. We report a case of a Philipino child carrying the G6PD-Vanua Lava mutation with acute haemolytic crisis related to infection in progress and acetaminophen's administration...
May 2011: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/18197587/-a-young-man-with-acute-generalised-jaundice-and-intermittent-epigastric-pain
#4
B Walz, B Riecken
HISTORY: A 24-year-old Iraqi was admitted to our hospital with acute generalised jaundice and intermittent epigastric pain. His family doctor suspected a viral hepatitis. Two days prior admission the patient had consumed large quantities of alcohol and had subsequently taken analgetic dosages of paracetamol and acetylsalicylic acid. INVESTIGATIONS: Besides an otherwise inconspicuous physical examination the laboratory results revealed a distinct hemolysis with macrocytic, hyperchromic anaemia and negative Coombs-test...
January 2008: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/10918522/repeated-acetaminophen-dosing-in-rats-adaptation-of-hepatic-antioxidant-system
#5
P J O'Brien, M R Slaughter, A Swain, J M Birmingham, R W Greenhill, F Elcock, P J Bugelski
Repeated dosing of acetaminophen (paracetamol) to rats is reported to decrease their sensitivity to its hepatotoxic effects, which are associated with oxidative stress and glutathione depletion. We determined if repeated acetaminophen dosing produced adaptive response of key antioxidant system enzymes. Male rats (Sprague-Dawley, 10 weeks) were given 800, 1200, or 1600 mg/kg/day acetaminophen by oral gavage for 4 days. Liver was assayed for oxidative stress and antioxidant markers: malondialdehyde (MDA), thiobarbituric acid reactive substance (TBARS), total antioxidant status (TAS), glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PD), catalase (CAT), and superoxide dismutase (SOD), and alanine transaminase (ALT) as a marker of hepatocellular injury...
May 2000: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/1201217/g6pd-hillbrow-a-new-variant-of-glucose-6-phosphate-dehydrogenase-associated-with-drug-induced-haemolytic-anaemia
#6
E Cayanis, E D Gomperts, D Balinsky, P Disler, A Myers
A new genetic variant of the red cell enzyme glucose-6-phosphate dehydrogenase is described. It was observed in a patient presenting with severe haemolytic anaemia and renal failure following ingestion of an overdose of Beserol (paracetamol and chlormezanone). The enzyme in the red cell had 12% of the activity of a normal B+ control, but only slightly lower activity in the kidney compared with a normal control. The red cell enzyme showed normal electrophoretic mobility and thermostability, a biphasic pH optimum curve, higher than normal utilization of the substrate analogues 2-deoxy-glucose-6-phosphate and deamino-NADP, and lower than normal Michaelis constants for both substrates, glucose-6-phosphate and NADP...
July 1975: British Journal of Haematology
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