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https://www.readbyqxmd.com/read/29656592/the-applicability-of-furfuryl-gelatin-as-a-novel-bioink-for-tissue-engineering-applications
#1
Shweta AnilKumar, Shane C Allen, Nishat Tasnim, Tahmina Akter, Shinhye Park, Alok Kumar, Munmun Chattopadhyay, Yoshihiro Ito, Laura J Suggs, Binata Joddar
Three-dimensional bioprinting is an innovative technique in tissue engineering, to create layer-by-layer structures, required for mimicking body tissues. However, synthetic bioinks do not generally possess high printability and biocompatibility at the same time. So, there is an urgent need for naturally derived bioinks that can exhibit such optimized properties. We used furfuryl-gelatin as a novel, visible-light crosslinkable bioink for fabricating cell-laden structures with high viability. Hyaluronic acid was added as a viscosity enhancer and either Rose Bengal or Riboflavin was used as a visible-light crosslinker...
April 15, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29656544/an-overview-on-the-identification-of-mait-cell-antigens
#2
Lars Kjer-Nielsen, Alexandra J Corbett, Zhenjun Chen, Ligong Liu, Jeffrey Y W Mak, Dale I Godfrey, Jamie Rossjohn, David P Fairlie, James McCluskey, Sidonia B G Eckle
Mucosal Associated Invariant T (MAIT) cells are restricted by the monomorphic MHC class I-like molecule, MHC-related protein-1 (MR1). Until 2012, the origin of the MAIT cell antigens (Ags) was unknown, although it was established that MAIT cells could be activated by a broad range of bacteria and yeasts, possibly suggesting a conserved Ag. Using a combination of protein chemistry, mass spectrometry, cellular biology, structural biology and chemistry, we discovered MAIT cell ligands derived from folic acid (vitamin B9) and from an intermediate in the microbial biosynthesis of riboflavin (vitamin B2)...
April 14, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29629900/recipient-mucosal-associated-invariant-t-cells-control-gvhd-within-the-colon
#3
Antiopi Varelias, Mark D Bunting, Kate L Ormerod, Motoko Koyama, Stuart D Olver, Jasmin Straube, Rachel D Kuns, Renee J Robb, Andrea S Henden, Leanne Cooper, Nancy Lachner, Kate H Gartlan, Olivier Lantz, Lars Kjer-Nielsen, Jeffrey Yw Mak, David P Fairlie, Andrew D Clouston, James McCluskey, Jamie Rossjohn, Steven W Lane, Philip Hugenholtz, Geoffrey R Hill
Mucosal-associated invariant T (MAIT) cells are a unique innate-like T cell subset that responds to a wide array of bacteria and yeast through recognition of riboflavin metabolites presented by the MHC class I-like molecule MR1. Here, we demonstrate using MR1 tetramers that recipient MAIT cells are present in small but definable numbers in graft-versus-host disease (GVHD) target organs and protect from acute GVHD in the colon following bone marrow transplantation (BMT). Consistent with their preferential juxtaposition to microbial signals in the colon, recipient MAIT cells generate large amounts of IL-17A, promote gastrointestinal tract integrity, and limit the donor alloantigen presentation that in turn drives donor Th1 and Th17 expansion specifically in the colon after BMT...
April 9, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29629048/prophylactic-effect-of-riboflavin-on-pediatric-migraine-a-randomized-double-blind-placebo-controlled-trial
#4
Ahmad Talebian, Babak Soltani, Hamid Reza Banafshe, Gholam Abbas Moosavi, Motahhareh Talebian, Siamak Soltani
Background and aim: Riboflavin may have an acceptable effect on migraine among children. This study was carried out to determine the prophylactic effect of riboflavin on migraine in children. Methods: This randomized clinical trial study was performed at Shahid Beheshti Hospital in Kashan, Iran from December 2012 to February 2015. Ninety children with migraine were allocated randomly into 3 groups (placebo, low-dose and high-dose riboflavin). The outcomes (frequency, intensity and duration of headaches) were measured at baseline and 12 weeks of medication in each group, and the decrease of them were compared...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29628656/comparative-evaluation-of-the-effect-of-10-sodium-ascorbate-10-hesperidin-1-riboflavin-5-phosphate-collagen-cross-linkers-on-the-pushout-bond-strength-of-fiber-postluted-to-radicular-dentin-in-vitro-study
#5
Kosha Jain, Lotika Beri, Kunal Kunjir, Nikhil Borse, Neha Neekhara, Aishwarya Kadam
Aims: The aim of the study was to evaluate the effect of 10% sodium ascorbate (SA),10% hesperidin, 1% riboflavin 5-phosphate, collagen cross-linkers, on the pushout bond strength of the fiber resin postluted to the radicular dentin. Materials and Methods: Twenty-eight, single-rooted extracted human teeth were collected. The cleaning shaping and obturation was done followed postspace preparation which was etched with 37% phosphoric acid for 15 s and then rinsed with normal saline...
January 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29623463/current-perspectives-on-corneal-collagen-crosslinking-cxl
#6
Sandeepani K Subasinghe, Kelechi C Ogbuehi, George J Dias
Corneal collagen crosslinking has revolutionized the treatment of keratoconus and post-refractive corneal ectasia in the past decade. Corneal crosslinking with riboflavin and ultraviolet A is proposed to halt the progression of keratectasia. In the original "Conventional Dresden Protocol" (C-CXL), the epithelium is removed prior to the crosslinking process to facilitate better absorption of riboflavin into the corneal stroma. Studies analyzing its short- and long-term outcomes revealed that although there are inconsistencies as to the effectiveness of this technique, the advantages prevail over the disadvantages...
April 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29620600/environmental-enteropathy-micronutrient-adequacy-and-length-velocity-in-nepalese-children-the-mal-ed-birth-cohort-study
#7
Marianne S Morseth, Sigrun Henjum, Catherine Schwinger, Tor A Strand, Sanjaya K Shrestha, Binob Shrestha, Ram K Chandyo, Manjeswori Ulak, Liv Elin Torheim
OBJECTIVES: Environmental enteropathy (EE) is likely associated with growth retardation in children, but the association between EE and length velocity z-score (LVZ) has not been investigated. The objective of the study was to assess associations between fecal markers for intestinal inflammation and LVZ and whether these associations were influenced by micronutrient adequacy among 9-24 months old children in Bhaktapur, Nepal. METHODS: Data was divided into 5 time slots (9-12, 12-15, 15-18, 18-21 and 21-24 months)...
April 3, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29619575/the-evidence-for-the-role-of-nutraceuticals-in-the-management-of-pediatric-migraine-a-review
#8
REVIEW
Serena L Orr
PURPOSE OF REVIEW: Nutraceuticals are a form of complementary and alternative medicine that is commonly used by children and adolescents with migraine. In this review, observational studies, randomized controlled trials, systematic reviews, and meta-analyses on the efficacy and safety of single compound nutraceuticals for the management of migraine in children and adolescents were identified through a literature search of MEDLINE, Embase, and EBM Reviews-Cochrane Central Register of Controlled Trials...
April 4, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29617851/effects-of-nutrition-intervention-on-total-and-cancer-mortality-25-year-post-trial-follow-up-of-the-5-25-year-linxian-nutrition-intervention-trial
#9
Shao-Ming Wang, Philip R Taylor, Jin-Hu Fan, Ruth M Pfeiffer, Mitchell H Gail, He Liang, Gwen A Murphy, Sanford M Dawsey, You-Lin Qiao, Christian C Abnet
Background: A beneficial effect of supplementation with selenium, vitamin E, and beta-carotene was observed on total and cancer mortality in a Chinese population, and it endured for 10 years postintervention, but longer durability is unknown. Methods: A randomized, double-blind, placebo-controlled trial was conducted in Linxian, China, from 1986 to 1991; 29 584 residents age 40 to 69 years received daily supplementations based on a factorial design: Factors A (retinol/zinc), B (riboflavin/niacin), C (vitamin C/molybdenum), and/or D (selenium/vitamin E/beta-carotene), or placebo for 5...
April 3, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29615664/metabolomics-coupled-with-pathway-analysis-characterizes-metabolic-changes-in-response-to-bde-3-induced-reproductive-toxicity-in-mice
#10
Ziheng Wei, Jing Xi, Songyan Gao, Xinyue You, Na Li, Yiyi Cao, Liupeng Wang, Yang Luan, Xin Dong
Polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. 4-bromodiphenyl ether (BDE-3), the photodegradation products of higher brominated PBDEs, is the most fundamental mono-BDE in environment but is less studied. The purpose of this study was to investigate the reproductive toxicity induced by BDE-3 and explore the mechanism by metabolomics approach. In this study, mice were treated intragastrically with BDE-3 for consecutive six weeks at the dosages of 0.0015, 1.5, 10 and 30 mg/kg...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615056/patient-with-multiple-acyl-coa-dehydrogenase-deficiency-disease-and-etfdh-mutations-benefits-from-riboflavin-therapy-a-case-report
#11
Liuh Ling Goh, Yingshan Lee, Ee Shien Tan, James Soon Chuan Lim, Chia Wei Lim, Rinkoo Dalan
BACKGROUND: Lipid storage myopathy (LSM) is a diverse group of lipid metabolic disorders with great variations in the clinical phenotype and age of onset. Classical multiple acyl-CoA dehydrogenase deficiency (MADD) is known to occur secondary to mutations in electron transfer flavoprotein dehydrogenase (ETFDH) gene. Whole exome sequencing (WES) with clinical correlations can be useful in identifying genomic alterations for targeted therapy. CASE PRESENTATION: We report a patient presented with severe muscle weakness and exercise intolerance, suggestive of LSM...
April 3, 2018: BMC Medical Genomics
https://www.readbyqxmd.com/read/29610214/two-component-flavin-dependent-riboflavin-monooxygenase-degrades-riboflavin-in-devosia-riboflavina
#12
Hiroshi Kanazawa, Ryosuke Shigemoto, Yukie Kawasaki, Ken-Ichi Oinuma, Akira Nakamura, Shunsuke Masuo, Naoki Takaya
The actinobacterium Microbacterium maritypicum splits riboflavin (vitamin B2 ) into lumichrome and d-ribose. However, such degradation by other bacteria and the involvement of a two-component flavin-dependent monooxygenase (FMO) in the reaction remain unknown. Here we investigated the mechanism of riboflavin degradation by the riboflavin-assimilating α-proteobacterium Devosia riboflavina (formerly Pseudomonas riboflavina ). We found that adding riboflavin to bacterial cultures induced riboflavin-degrading activity and a protein of the FMO family that had 67% amino-acid identity with the predicted riboflavin hydrolase, RcaE, of M...
April 2, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29606427/%C3%AE-and-%C3%AE-casein-aggregation-induced-by-riboflavin-sensitized-photo-oxidation-occurs-via-di-tyrosine-cross-links-and-is-oxygen-concentration-dependent
#13
E Fuentes-Lemus, E Silva, F Leinisch, E Dorta, L G Lorentzen, M J Davies, C López-Alarcón
Type I photo-oxidation generates Trp-(TrpN) and Tyr-derived (TyrO) radicals in proteins which can dimerize producing cross-links, or alternatively react with O2 . It was therefore hypothesized that the O2 concentration may have a significant effect on dye-photosensitized reactions. We studied photo-oxidation of α- and β-caseins induced by riboflavin (RF), a photosensitizing vitamin present in milk, under aerobic and anaerobic conditions. Triplet-state RF induced oxidative modifications on both caseins, and significant levels of cross-links...
August 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29577824/cavitating-leukoencephalopathy-with-posterior-predominance-caused-by-a-deletion-in-the-apopt1-gene-in-an-indian-boy
#14
Suvasini Sharma, Preeti Singh, Erika Fernandez-Vizarra, Massimo Zeviani, Marjo S Van der Knaap, Ravindra Kumar Saran
A 5-year-old Indian boy presented with subacute onset regression of milestones associated with seizures and spasticity. The symptoms started after an attack of measles. The magnetic resonance imaging (MRI) of the brain showed cavitating leukodystrophy with posterior predominance. Molecular analysis of the APOPT1 gene, a recently described gene associated with mitochondrial leukodystrophy, showed the patient to be homozygous for a 12.82-kilobase deletion, including coding exon 3. Deletion of exon 3 produces a frameshift, predicting the translation of a truncated protein (p...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29576618/effects-of-collagen-cross-linking-on-the-keratoconus-metabolic-network
#15
Rabab Sharif, Henrik Sejersen, Garrett Frank, Jesper Hjortdal, Dimitrios Karamichos
PURPOSE: Keratoconus (KC) is a multifactorial, ectatic corneal disease. Metabolic changes in the corneal stroma with alterations in collagen fibril stability, oxidative stress, and urea cycle, have previously been reported as key players in KC pathobiology. Recently, corneal collagen cross-linking (CXL) has been introduced as a treatment that can address the progressive nature of KC. While the treatment has been successful in the early days, it is not without clinical ramifications. In this study, we investigated the alterations in KC metabolic profiles due to CXL...
March 26, 2018: Eye
https://www.readbyqxmd.com/read/29576276/liquid-chromatography-with-alkylammonium-formate-ionic-liquid-mobile-phases-and-fluorescence-detection
#16
Neil D Danielson, Fotouh R Mansour, Ling Zhou, Casey V Connell, Erin M Dotlich, Justin N Gibler, Blake E Norman, Shau Grossman, Wenjun Wei, Ying Zhang
Fluorescence detection of various pharmaceuticals and the amino acid tryptophan (low molecular weight organic compounds) as well as the enzyme lactate dehydrogenase LDH (high molar mass compound) has been studied in aqueous solutions using alkyl ammonium formate ionic liquids as the primary solvent component. It was expected that the high viscosity of such ionic liquid-water mixtures would enhance fluorescence. Pharmaceuticals such as riboflavin and naproxen showed no such enhancement in the presence of ethylammonium formate (EAF) or isopropylammonium formate (IPAF) but the fluorescence of warfarin was substantially enhanced by a factor of 4 with 80% EAF and a factor of 7 with 70% IPAF...
March 14, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29571016/the-role-of-nutrients-in-the-pathogenesis-and-treatment-of-migraine-headaches-review
#17
REVIEW
Elyas Nattagh-Eshtivani, Mahmood Alizadeh Sani, Monireh Dahri, Faezeh Ghalichi, Abed Ghavami, Pishva Arjang, Ali Tarighat-Esfanjani
OBJECTIVE: Migraine as a disabling neurovascular disease affects 6% of men and 18% of women worldwide. The deficiency of many nutrients including magnesium, niacin, riboflavin, cobalamin, coenzymes Q10, carnitine, α-lipoic acid and vitamin D is associated with migraine. Some researchers postulate that mitochondrial dysfunction and impaired antioxidant status can cause migraine. Also increase in homocysteine level can lead to migraine attacks; therefore, some Nutraceuticals play a vital role in migraine prevention...
March 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29565276/dietary-niacin-and-open-angle-glaucoma-the-korean-national-health-and-nutrition-examination-survey
#18
Kyoung In Jung, Yong Chan Kim, Chan Kee Park
Glaucoma is a leading cause of loss of sight. High intraocular pressure (IOP) is the most critical risk factor. However, glaucoma develops even within a normal IOP range. Normal tension glaucoma (NTG) is more common in Asia, whereas high tension glaucoma is more common in Western countries. The pathogenesis of glaucoma, especially NTG, is poorly understood. We evaluated the correlation between dietary nutrient intake and glaucoma using data from subjects ≥40 years old from the ongoing, nationwide, population-based study, the Korean National Health and Nutrition Examination Survey V (2008-2012)...
March 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29565150/micronutrient-intake-in-elderly-living-in-nursing-homes
#19
Bruno Santos Assis, Jairza Maria Barreto-Medeiros Jairza, Jamile Almeida Lopes, Ana Karla Carneiro Roriz, Adriana Lima Melo, Agatha Previdell, Rita De Cássia Aquino, Lilian Barbosa Ramos
OBJECTIVE: The aim of this study was to evaluate the ingestion of micronutrients in elderly living in nursing homes. METHODS: This is a cross-sectional study, conducted with 216 individuals of both sexes, age equal or greater than 60 years, living in nursing homes for elderly in Salvador, Bahia, Brazil. Direct weighing of the food was used to get food intake, and prevalence of inadequacy was obtained using the software Multiple Source Method (MSM) and evaluated by estimated average requirement (EAR)...
February 13, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29564806/prospective-randomized-contralateral-eye-study-of-accelerated-and-conventional-corneal-cross-linking-in-pediatric-keratoconus
#20
Sherif A Eissa, Amr Yassin
PURPOSE: To compare the outcomes of two different cross-linking (CXL) protocols, in pediatric keratoconus eyes. MATERIALS AND METHODS: In this prospective randomized contralateral eye interventional study, 68 eyes of 34 patients, 9-16 years old, underwent CXL and enrolled between October 2011 and October 2013. Group A represents conventional riboflavin-ultraviolet A (UVA)-induced CXL with 30 min of exposure to UVA irradiation of 3 mW/cm2 . Group B represents accelerated cross-linking with 5 min of continuous UVA irradiation of 18 mW/cm2 ...
March 21, 2018: International Ophthalmology
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