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https://www.readbyqxmd.com/read/28079590/the-evaluation-of-corneal-fragility-after-uva-riboflavin-crosslinking
#1
Zhiwei Li, Yumeng Wang, Yanyun Xu, Vishal Jhanji, Chunxiao Zhang, Guoying Mu
PURPOSE: To evaluate the fragility of cornea after UVA/riboflavin crosslinking (CXL). METHODS: Sixty New Zealand rabbits received UVA/riboflavin crosslinking treatment (wavelength 365 nm, irradiance 3.0 mW/cm, and total dose 5.4 J/cm) on right eyes. Animals were sacrificed before and immediately after treatment (day 0), day 1, 3, 7, and 28 after treatment. A 4×10 mm corneal strip for biomechanical evaluation was harvested after sacrifice. The corneal fragility was evaluated by measurement of elongation rate, whereby the elongation rate equals elongation length/baseline length...
January 10, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28073944/a-novel-bifunctional-transcriptional-regulator-of-riboflavin-metabolism-in-archaea
#2
Irina A Rodionova, Matthew W Vetting, Xiaoqing Li, Steven C Almo, Andrei L Osterman, Dmitry A Rodionov
Riboflavin (vitamin B2) is the precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide, which are essential coenzymes in all free-living organisms. Riboflavin biosynthesis in many Bacteria but not in Archaea is controlled by FMN-responsive riboswitches. We identified a novel bifunctional riboflavin kinase/regulator (RbkR), which controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain...
January 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28070495/an-atypical-presentation-of-acad9-deficiency-diagnosis-by-whole-exome-sequencing-broadens-the-phenotypic-spectrum-and-alters-treatment-approach
#3
H K Aintablian, V Narayanan, N Belnap, K Ramsey, T A Grebe
Acyl-CoA dehydrogenase 9 (ACAD9), linked to chromosome 3q21.3, is one of a family of multimeric mitochondrial flavoenzymes that catalyze the degradation of fatty acyl-CoA from the carnitine shuttle via β-oxidation (He et al. 2007). ACAD9, specifically, is implicated in the processing of palmitoyl-CoA and long-chain unsaturated substrates, but unlike other acyl-CoA dehydrogenases (ACADs), it has a significant role in mitochondrial complex I assembly (Nouws et al. 2010 & 2014). Mutations in this enzyme typically cause mitochondrial complex I deficiency, as well as a mild defect in long chain fatty acid metabolism (Haack et al...
March 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28068449/repeated-cross-linking-after-a-short-time-does-not-provide-any-additional-biomechanical-stiffness-in-the-mouse-cornea-in-vivo
#4
David Tabibian, Sabine Kling, Arthur Hammer, Olivier Richoz, Farhad Hafezi
PURPOSE: To study whether repeated collagen cross-linking (CXL) performed in vivo in mice shows an additive effect on mechanical corneal stiffness. METHODS: In this experimental study, epithelium-off CXL was performed in a total of 18 eyes from male C57BL/6 mice, with 0.27%-riboflavin solution applied for 20 minutes, followed by ultraviolet-A (UVA) irradiation (365 nm, 9mW/cm(2)) for 2:50 minutes (fluence 1.53 J/cm(2)). CXL was performed as either a single (1×CXL) or a repeated (2×CXL) treatment...
January 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28055099/evaluation-of-therapeutic-tissue-crosslinking-txl-for-myopia-using-second-harmonic-generation-signal-microscopy-in-rabbit-sclera
#5
Mariya Zyablitskaya, Anna Takaoka, Emilia L Munteanu, Takayuki Nagasaki, Stephen L Trokel, David C Paik
Purpose: Second harmonic generation signals (SHG) are emitted preferentially from collagenous tissue structures and have been used to evaluate photochemically-induced (CXL) crosslinking changes in the cornea. Since therapeutic tissue crosslinking (TXL) using sodium hydroxymethylglycinate (SMG) of the sclera is a potential treatment for high myopia, we explored the use of SHG microscopy to evaluate the effects. Methods: Single sub-Tenon's (sT) injections (400 μL) using SMG (40-400 mM) were made at the equatorial 12 o'clock position of the right eye of cadaveric rabbit heads (n = 16 pairs)...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28055060/optical-coherence-elastography-for-evaluating-customized-riboflavin-uv-a-corneal-collagen-crosslinking
#6
Manmohan Singh, Jiasong Li, Srilatha Vantipalli, Zhaolong Han, Kirill V Larin, Michael D Twa
No abstract text is available yet for this article.
September 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28053663/utilization-of-xylose-by-engineered-strains-of-ashbya-gossypii-for-the-production-of-microbial-oils
#7
David Díaz-Fernández, Patricia Lozano-Martínez, Rubén M Buey, José Luis Revuelta, Alberto Jiménez
BACKGROUND: Ashbya gossypii is a filamentous fungus that is currently exploited for the industrial production of riboflavin. The utilization of A. gossypii as a microbial biocatalyst is further supported by its ability to grow in low-cost feedstocks, inexpensive downstream processing and the availability of an ease to use molecular toolbox for genetic and genomic modifications. Consequently, A. gossypii has been also introduced as an ideal biotechnological chassis for the production of inosine, folic acid, and microbial oils...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28031696/under-flap-stromal-bed-cxl-for-early-post-lasik-ectasia-a-novel-treatment-technique
#8
Avi Wallerstein, Eser Adiguzel, Mathieu Gauvin, Nima Mohammad-Shahi, Mark Cohen
PURPOSE: Collagen cross-linking (CXL) for post-laser-assisted in situ keratomileusis (LASIK) ectasia (PLE) is traditionally performed either epi-on or epi-off on the corneal surface. This study describes a novel technique in treating early PLE with under-flap CXL (ufCXL) to the stromal bed and reports on 6-month outcomes. PATIENTS AND METHODS: Case series of seven patients (eight eyes) with topography-diagnosed early PLE treated with ufCXL. Inclusion criteria were early, mild PLE defined as new-onset postoperative manifest refraction cylinder ≤1...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28019031/pathogen-inactivation-by-riboflavin-and-ultraviolet-light-illumination-accelerates-the-red-blood-cell-storage-lesion-and-promotes-eryptosis
#9
Syed M Qadri, Deborah Chen, Peter Schubert, Darian L Perruzza, Varsha Bhakta, Dana V Devine, William P Sheffield
BACKGROUND: Pathogen reduction treatment using riboflavin and ultraviolet light illumination (Mirasol) effectively reduces the risk of transfusion-transmitted infections. This treatment is currently licensed for only platelets and plasma products, while its application to whole blood (WB) to generate pathogen-inactivated red blood cells (RBCs) is under development. RBC storage lesion, constituting numerous morphologic and biochemical changes, influences RBC quality and limits shelf life...
December 26, 2016: Transfusion
https://www.readbyqxmd.com/read/28009397/corneal-collagen-crosslinking-for-corneal-ectasias-a-review
#10
David P S O'Brart
PURPOSE: To review the published literature on corneal collagen crosslinking (CXL). METHODS: Importance has been placed on seminal publications, systemic reviews, meta-analyses, and randomized controlled clinical trials. Where such evidence was not available, cohort studies, case-controlled studies, and case series with follow-up greater than 12 months were examined. RESULTS: Corneal collagen crosslinking with riboflavin and ultraviolet A (UVA) 370 nm radiation appears to be capable of arresting the progression of ectatic corneal disorders, with most studies reporting significant improvements in visual, keratometric, and topographic measurements...
December 6, 2016: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28008713/engineering-ashbya-gossypii-strains-for-de-novo-lipid-production-using-industrial-by-products
#11
Patricia Lozano-Martínez, Rubén M Buey, Rodrigo Ledesma-Amaro, Alberto Jiménez, José Luis Revuelta
Ashbya gossypii is a filamentous fungus that naturally overproduces riboflavin, and it is currently exploited for the industrial production of this vitamin. The utilization of A. gossypii for biotechnological applications presents important advantages such as the utilization of low-cost culture media, inexpensive downstream processing and a wide range of molecular tools for genetic manipulation, thus making A. gossypii a valuable biotechnological chassis for metabolic engineering. A. gossypii has been shown to accumulate high levels of lipids in oil-based culture media; however, the lipid biosynthesis capacity is rather limited when grown in sugar-based culture media...
December 23, 2016: Microbial Biotechnology
https://www.readbyqxmd.com/read/28007489/proposal-for-a-breakfast-quality-index-for-brazilian-population-rationale-and-application-in-the-brazilian-national-dietary-survey
#12
Jaqueline Lopes Pereira, Michelle Alessandra de Castro, Sinead Hopkins, Carolyn Gugger, Regina Mara Fisberg, Mauro Fisberg
Breakfast has been related to positive nutrition and health outcomes, but criteria for an optimal composition of this meal are not well established. The aim of this study was to propose a breakfast quality index (BQI) for the Brazilian population, and to describe the relationship between breakfast quality, socio-demographic factors, dietary intake at breakfast and for the total day. BQI was constructed based on individual dietary data of 22,279 breakfast consumers, aged 20+ years from the Brazilian National Dietary Survey, a population-based cross-sectional study...
December 19, 2016: Appetite
https://www.readbyqxmd.com/read/28003986/therapeutic-and-inducing-effect-of-corneal-crosslinking-on-infectious-keratitis
#13
REVIEW
Liang-Zhu Jiang, Shi-Yan Qiu, Zhi-Wei Li, Xiao Zhang, Xiang-Chen Tao, Guo-Ying Mu
The corneal crosslinking (CXL) with riboflavin and ultraviolet-A (UVA) is a new therapy method to successfully treat infectious keratitis in clinical practice. However, there are rare reports on the complications of CXL such as the secondary keratitis. The diverse clinical outcomes on keratitis have highlighted the necessity to further evaluate the efficacy and complications of CXL. We reviewed the positive and negative reports on UVA/riboflavin related with keratitis and provided our opinion on the therapeutic and side effect of UVA/riboflavin crosslinking on keratitis...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28003292/eatwell-guide-modelling-the-dietary-and-cost-implications-of-incorporating-new-sugar-and-fibre-guidelines
#14
Peter Scarborough, Asha Kaur, Linda Cobiac, Paul Owens, Alexandr Parlesak, Kate Sweeney, Mike Rayner
OBJECTIVES: To model food group consumption and price of diet associated with achieving UK dietary recommendations while deviating as little as possible from the current UK diet, in order to support the redevelopment of the UK food-based dietary guidelines (now called the Eatwell Guide). DESIGN: Optimisation modelling, minimising an objective function of the difference between population mean modelled and current consumption of 125 food groups, and constraints of nutrient and food-based recommendations...
December 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/28001293/experiences-with-semi-routine-production-of-riboflavin-and-uv-b-pathogen-inactivated-platelet-concentrates-in-three-blood-centres
#15
P F van der Meer, C Couture, T Hervig, G Kruit, D V Devine, D de Korte, J-L Kerkhoffs
BACKGROUND: For a clinical platelet (PLT) transfusion trial conducted in three countries, the production of PLT concentrates (PCs) that were pathogen inactivated with the Mirasol technology was set up and validated. While the Mirasol procedure is applied to an established PLT product, the PLT processing procedure still had to be modified to ensure a treated PC was of sufficient quality. Further, the effect of simulated transport conditions and the effect of ambient light on Mirasol-treated PCs was determined...
December 21, 2016: Vox Sanguinis
https://www.readbyqxmd.com/read/27994318/resin-bond-strength-to-water-versus-ethanol-saturated-human-dentin-pretreated-with-three-different-cross-linking-agents
#16
Bhuvan Shome Venigalla, Pinnamreddy Jyothi, Shekhar Kamishetty, Smitha Reddy, Ravi Chandra Cherukupalli, Depa Arun Reddy
CONTEXT: Resin-dentin bonds are unstable owing to hydrolytic and enzymatic degradation. Several approaches such as collagen cross-linking and ethanol-wet bonding (EWB) have been developed to overcome this problem. Collagen cross-linking improves the intrinsic properties of the collagen matrix. However, it leaves a water-rich collagen matrix with incomplete resin infiltration making it susceptible to fatigue degradation. Since EWB is expected to overcome the drawbacks of water-wet bonding (WWB), a combination of collagen cross-linking with EWB was tested...
November 2016: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/27983705/riboflavin-reduces-pro-inflammatory-activation-of-adipocyte-macrophage-co-culture-potential-application-of-vitamin-b2-enrichment-for-attenuation-of-insulin-resistance-and-metabolic-syndrome-development
#17
Agnieszka Irena Mazur-Bialy, Ewa Pocheć
Due to the progressive increase in the incidence of obese and overweight individuals, cardiometabolic syndrome has become a worldwide pandemic in recent years. Given the immunomodulatory properties of riboflavin, the current study was performed to investigate the potency of riboflavin in reducing obesity-related inflammation, which is the main cause of insulin resistance, diabetes mellitus 2 or arteriosclerosis. We determined whether pretreatment with a low dose of riboflavin (10.4-1000 nM) affected the pro-inflammatory activity of adipocyte-macrophage co-culture (3T3 L1-RAW 264...
December 15, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27981706/the-crystal-structure-of-rosb-insights-into-the-reaction-mechanism-of-the-first-member-of-a-family-of-flavodoxin-like-enzymes
#18
Valentino Konjik, Steffen Brünle, Ulrike Demmer, Amanda Vanselow, Roger Sandhoff, Ulrich Ermler, Matthias Mack
8-demethyl-8-aminoriboflavin-5'-phosphate (AFP) synthase (RosB) catalyzes the key reaction of roseoflavin biosynthesis by forming AFP from riboflavin-5'-phosphate (RP) and glutamate via the intermediates 8-demethyl-8-formylriboflavin-5'-phosphate (OHC-RP) and 8-demethyl-8-carboxylriboflavin-5'-phosphate (HO2 C-RP). To understand this reaction in which a methyl substituent of an aromatic ring is replaced by an amine we structurally characterized RosB in complex with OHC-RP (2.0 Å) and AFP (1.7 Å). RosB is composed of four flavodoxin-like subunits which have been upgraded with specific extensions and a unique C-terminal arm...
December 16, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27979196/b-vitamins-carotenoids-and-%C3%AE-%C3%AE-tocopherol-in-raw-and-roasted-nuts
#19
Wolfgang Stuetz, Wiebke Schlörmann, Michael Glei
The concentrations of B-vitamins, carotenoids and tocopherols in nuts may differ between species and might be influenced by roasting. Thiamine, riboflavin, pyridoxine, lutein, zeaxanthin, β-carotene and α-/γ-tocopherol were determined in different varieties of raw and roasted nuts using HPLC (fluorescence/UV-vis detection). The analysis revealed remarkable concentrations of thiamine and pyridoxine in pistachios (57%, 79% of the recommended daily intake/100g (RDI), respectively) and riboflavin in almonds (119% of the RDI)...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27974309/analytical-ingredient-content-and-variability-of-adult-multivitamin-mineral-products-national-estimates-for-the-dietary-supplement-ingredient-database
#20
Karen W Andrews, Janet M Roseland, Pavel A Gusev, Joel Palachuvattil, Phuong T Dang, Sushma Savarala, Fei Han, Pamela R Pehrsson, Larry W Douglass, Johanna T Dwyer, Joseph M Betz, Leila G Saldanha, Regan L Bailey
BACKGROUND: Multivitamin/mineral products (MVMs) are the dietary supplements most commonly used by US adults. During manufacturing, some ingredients are added in amounts exceeding the label claims to compensate for expected losses during the shelf life. Establishing the health benefits and harms of MVMs requires accurate estimates of nutrient intake from MVMs based on measures of actual rather than labeled ingredient amounts. OBJECTIVES: Our goals were to determine relations between analytically measured and labeled ingredient content and to compare adult MVM composition with Recommended Dietary Allowances (RDAs) and Tolerable Upper Intake Levels...
December 14, 2016: American Journal of Clinical Nutrition
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