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https://www.readbyqxmd.com/read/27910295/combined-application-of-prophylactic-corneal-cross-linking-and-laser-in-situ-keratomileusis-a-review-of-literature
#1
REVIEW
Tommy C Y Chan, Alex L K Ng, Karen K W Chan, George P M Cheng, Ian Y H Wong, Vishal Jhanji
Laser in-situ keratomileusis (LASIK) is safe and effective laser refractive procedures in treating refractive errors. However, regression of treatment and iatrogenic keratectasia remain to be a major concern, especially in treating thin cornea with high ametropia. Collagen cross-linking (CXL) is an effective method in stopping keratoconus progression through increasing the biomechanical strength of the cornea. Adjuvant cross-linking to refractive procedures can theoretically help prevent regression and reduce the risk of keratectasia development by increasing the mechanical stability of cornea...
December 2, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27909558/nutritional-quality-of-lunches-consumed-by-korean-workers-comparison-between-institutional-and-commercial-lunches
#2
Won Gyoung Kim, Injoo Choi, Jihyun Yoon
BACKGROUND/OBJECTIVES: The nutritional quality of lunches is an important factor related to workers' health. This study examined the nutritional quality of Korean workers' lunches with a focus on comparing institutional and commercial lunches. SUBJECTS/METHODS: The data from a 1-day, 24-hour dietary recall from the 5(th) Korea National Health and Nutrition Examination Survey (2010-2012) were analyzed. A total of 2,192 subjects aged 19 to 64 years, who had consumed lunches served by institutional or commercial food service vendors, were included for analysis...
December 2016: Nutrition Research and Practice
https://www.readbyqxmd.com/read/27905125/gadd45%C3%AE-is-involved-in-the-apoptosis-of-lymphocytes-induced-by-riboflavin-and-ultraviolet-light
#3
Peng Yang, Huiqin Wen, Tao Zhong, Hailiang Hu, Bangqiang Zhu, Kang Xia, Mo Xu, Maohong Bian
BACKGROUND: Riboflavin plus ultraviolet (UV) pathogen reduction technology (RF-PRT) is an effective method for inactivating the residual white blood cells (WBCs) in blood components. The RF-PRT system for platelets is known to activate many signaling pathways, including p38 and NF-κB. Nevertheless, proteomic studies in WBCs after riboflavin plus UV treatment requires further analysis. STUDY DESIGN AND METHODS: ABO/D-matched lymphocytes were pooled, split, and treated with RF-PRT or UV light or left untreated...
December 1, 2016: Transfusion
https://www.readbyqxmd.com/read/27904735/urinary-metabolomics-of-young-italian-autistic-children-supports-abnormal-tryptophan-and-purine-metabolism
#4
Federica Gevi, Lello Zolla, Stefano Gabriele, Antonio M Persico
BACKGROUND: Autism spectrum disorder (ASD) is still diagnosed through behavioral observation, due to a lack of laboratory biomarkers, which could greatly aid clinicians in providing earlier and more reliable diagnoses. Metabolomics on human biofluids provides a sensitive tool to identify metabolite profiles potentially usable as biomarkers for ASD. Initial metabolomic studies, analyzing urines and plasma of ASD and control individuals, suggested that autistic patients may share some metabolic abnormalities, despite several inconsistencies stemming from differences in technology, ethnicity, age range, and definition of "control" status...
2016: Molecular Autism
https://www.readbyqxmd.com/read/27902872/happens-in-the-best-of-subfamilies-establishment-and-repeated-replacements-of-co-obligate-secondary-endosymbionts-within-lachninae-aphids
#5
Alejandro Manzano-Marín, Gitta Szabo, Jean-Christophe Simon, Matthias Horn, Amparo Latorre
Virtually all aphids maintain an obligate mutualistic symbiosis with bacteria from the Buchnera genus, which produce essential nutrients for their aphid hosts. Most aphids from the Lachninae subfamily have been consistently found to house additional endosymbionts, mainly Serratia symbiotica. This apparent dependence on secondary endosymbionts was proposed to have been triggered by the loss of the riboflavin biosynthetic capability by Buchnera in the Lachninae last common ancestor. However, an integral large-scale analysis of secondary endosymbionts in the Lachninae is still missing, hampering the interpretation of the evolutionary and genomic analyses of these endosymbionts...
November 30, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27898982/evaluation-of-corneal-cross-linking-for-treatment-of-fungal-keratitis-using-confocal-laser-scanning-microscopy-on-an-ex-vivo-human-corneal-model
#6
Jawaher M Alshehri, David Caballero-Lima, M Chantal Hillarby, Susan G Shawcross, Arun Brahma, Fiona Carley, Nick D Read, Hema Radhakrishnan
Purpose: Some previous reports have established the use of photoactivated chromophore-induced corneal cross-linking (PACK-CXL) in treating fungal keratitis. The results of these case reports have often been conflicting. To systematically study the effect of PACK-CXL in the management of Fusarium keratitis, we have developed an ex vivo model of human corneal infection using eye-banked human corneas. Methods: Sixteen healthy ex vivo human corneas were divided into four study groups: (1) untreated control, (2) cross-linked, (3) infected with fungal spores, and (4) infected with fungal spores and then cross-linked...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27898428/beneficial-effects-of-a-dietary-weight-loss-intervention-on-human-gut-microbiome-diversity-and-metabolism-are-not-sustained-during-weight-maintenance
#7
Femke-Anouska Heinsen, Daniela Fangmann, Nike Müller, Dominik M Schulte, Malte C Rühlemann, Kathrin Türk, Ute Settgast, Wolfgang Lieb, John F Baines, Stefan Schreiber, Andre Franke, Matthias Laudes
OBJECTIVE: In the present study, we examined the effect of a very low-calorie diet(VLCD)-based obesity program on human gut microbiome diversity and metabolism during weight loss and weight maintenance. METHODS: Obese subjects underwent 3 months of VLCD followed by 3 months of weight maintenance. A lean and an obese control group were included. The microbiome was characterized by performing high-throughput dual-indexed 16S rDNA amplicon sequencing. RESULTS: At baseline, a significant difference in the Firmicutes/Bacteroidetes ratio between the lean and obese individuals was observed (p = 0...
November 30, 2016: Obesity Facts
https://www.readbyqxmd.com/read/27898225/plasma-riboflavin-level-is-associated-with-risk-relapse-and-survival-of-esophageal-squamous-cell-carcinoma
#8
Shan-Shan Li, Yi-Wei Xu, Jian-Yi Wu, Hua-Zhen Tan, Zhi-Yong Wu, Yu-Jie Xue, Jian-Jun Zhang, En-Min Li, Li-Yan Xu
Riboflavin is an essential micronutrient for normal cellular activity, and deficiency may result in disease, such as cancer. We performed a case-control study to explore the association of riboflavin levels with risk and prognosis of esophageal squamous cell carcinoma (ESCC). Plasma riboflavin levels, as measured by enzyme-linked immunosorbent assay (ELISA), in ESCC patients were significantly lower than in those of healthy controls (7.04 ± 6.34 ng/ml vs. 9.32 ± 12.40 ng/ml; P < 0.05). Moreover, there was an inverse relationship between riboflavin level and risk of ESCC (odds ratio (OR) = 0...
November 29, 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27892757/basic-principles-and-current-status-of-transcorneal-and-transscleral-iontophoresis
#9
Taís Gratieri, Verena Santer, Yogeshvar N Kalia
Iontophoresis is an active non-invasive drug delivery technique that can increase the transport of charged and neutral molecules into and across biological membranes. Most research to-date has focused on (per)cutaneous iontophoretic drug delivery. However, recent studies illustrate its potential for drug delivery to the eye: corneal iontophoresis may enable targeted topical therapy of intracorneal diseases, whereas transscleral iontophoresis may enable non-invasive intraocular drug delivery. Areas covered: We describe iontophoretic principles in the context of ocular delivery before providing a summary of recent preclinical studies involving transcorneal and transscleral iontophoresis in vitro and in vivo...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27886772/selective-and-sensitive-electrochemical-device-for-direct-vb2-determination-in-real-products
#10
Agata Kowalczyk, Monika Sadowska, Beata Krasnodebska-Ostrega, Anna M Nowicka
The developed by us electrochemical device for vitamin B2 (VB2; riboflavin) determination, without preconcentration step, in real products exhibits high sensitivity, selectivity, stability and low detection limit compared to those described in the literature. The determination procedure was based on the monitoring of the reduction current signal of VB2 bound with dsDNA anchored to the electrode surface through intermediary - carboxyphenyl layer. The application of such intermediary layer formed during electroreduction of appropriate diazonium salt at CV peak potential guarantees high efficiency of hybridization process and thus fully available places for VB2 interaction...
January 15, 2017: Talanta
https://www.readbyqxmd.com/read/27873546/evaluation-of-the-effect-of-soymilk-fermented-by-a-riboflavin-producing-lactobacillus-plantarum-strain-in-a-murine-model-of-colitis
#11
R Levit, G Savoy de Giori, A de Moreno de LeBlanc, J G LeBlanc
Inflammatory bowel diseases (IBD) are idiopathic diseases of the gastrointestinal tract characterised by recurrent inflammation that require lifelong treatments. It has been shown that certain strains of lactic acid bacteria (LAB) can produce specific health-promoting compounds in foods or in the gastrointestinal tract that can in turn prevent and/or treat IBD. This study was designed to evaluate the possible therapeutic potential of soymilk fermented by the riboflavin-producing strain Lactobacillus plantarum CRL 2130 in a trinitrobenzene sulfonic induced colitis mouse model...
November 22, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27865502/retail-lighting-and-packaging-influence-consumer-acceptance-of-fluid-milk
#12
H L Potts, K N Amin, S E Duncan
Little is known about the effect of retail light-emitting diode (LED) exposure on consumer acceptance of milk. The study objective was to determine effects of fluorescent and LED lighting under retail storage conditions on consumer acceptance of milk. Consumer acceptance of milk stored under retail conditions was determined through sensory evaluation (2 studies; n = 150+ each) and analytical measures (dissolved oxygen, secondary oxidation products, riboflavin retention). Study 1 evaluated milk stored in high-density polyethylene (HDPE) packages for 4 h under LED light (960 lx)...
November 16, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27859333/reduced-mhc-alloimmunization-and-partial-tolerance-protection-with-pathogen-reduction-of-whole-blood
#13
Rachael P Jackman, Marcus O Muench, Heather Inglis, John W Heitman, Susanne Marschner, Raymond P Goodrich, Philip J Norris
BACKGROUND: Allogeneic blood transfusion can result in an immune response against major histocompatibility complex (MHC) antigens, potentially complicating future transfusions or transplants. We previously demonstrated that pathogen reduction of platelet-rich plasma (PRP) with riboflavin and ultraviolet light (UV+R) can prevent alloimmunization in mice. A similar pathogen-reduction treatment is currently under development for the treatment of whole blood using riboflavin and a higher dose of UV light...
November 18, 2016: Transfusion
https://www.readbyqxmd.com/read/27855901/effects-and-mechanisms-of-eugenol-isoeugenol-coniferylaldehyde-and-dihydroeugenol-on-the-riboflavin-sensitized-photooxidation-of-%C3%AE-terpinene-in-methanol
#14
Ju Yeon Lee, Mun Yhung Jung
The effects of eugenol, isoeugenol, coniferylaldehyde, and dihydroeugenol on the riboflavin-sensitized photooxidation of α-terpinene in methanol were studied. Riboflavin greatly accelerated α-terpinene oxidation in methanol during light illumination, resulting in two major oxidation products (p-cymene and ascaridole). The results clearly showed the involvement of Type I and II mechanisms. All the eugenols exerted strong protective activity on riboflavin sensitized photooxidation of α-terpinene. Dihydroeugenol showed the highest protective activity, followed by isoeugenol, coniferylaldehyde, and eugenol, in a decreasing order...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27854316/causes-consequences-and-public-health-implications-of-low-b-vitamin-status-in-ageing
#15
REVIEW
Kirsty Porter, Leane Hoey, Catherine F Hughes, Mary Ward, Helene McNulty
The potential protective roles of folate and the metabolically related B-vitamins (vitamins B12, B6 and riboflavin) in diseases of ageing are of increasing research interest. The most common cause of folate and riboflavin deficiencies in older people is low dietary intake, whereas low B12 status is primarily associated with food-bound malabsorption, while sub-optimal vitamin B6 status is attributed to increased requirements in ageing. Observational evidence links low status of folate and the related B-vitamins (and/or elevated concentrations of homocysteine) with a higher risk of degenerative diseases including cardiovascular disease (CVD), cognitive dysfunction and osteoporosis...
November 16, 2016: Nutrients
https://www.readbyqxmd.com/read/27847327/solid-cellulose-nanofiber-based-foams-towards-facile-design-of-sustained-drug-delivery-systems
#16
Anna J Svagan, Jan-Willem Benjamins, Zeinab Al-Ansari, Daniel Bar Shalom, Anette Müllertz, Lars Wågberg, Korbinian Löbmann
Control of drug action through formulation is a vital and very challenging topic within pharmaceutical sciences. Cellulose nanofibers (CNF) are an excipient candidate in pharmaceutical formulations that could be used to easily optimize drug delivery rates. CNF has interesting physico-chemical properties that, when combined with surfactants, can be used to create very stable air bubbles and dry foams. Utilizing this inherent property, it is possible to modify the release kinetics of the model drug riboflavin in a facile way...
November 12, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27845713/novel-approaches-to-investigate-one-carbon-metabolism-and-related-b-vitamins-in-blood-pressure
#17
REVIEW
Amy McMahon, Helene McNulty, Catherine F Hughes, J J Strain, Mary Ward
Hypertension, a major risk factor for heart disease and stroke, is the world's leading cause of preventable, premature death. A common polymorphism (677C→T) in the gene encoding the folate metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR) is associated with increased blood pressure, and there is accumulating evidence demonstrating that this phenotype can be modulated, specifically in individuals with the MTHFR 677TT genotype, by the B-vitamin riboflavin, an essential co-factor for MTHFR. The underlying mechanism that links this polymorphism, and the related gene-nutrient interaction, with hypertension is currently unknown...
November 11, 2016: Nutrients
https://www.readbyqxmd.com/read/27845017/effect-of-spring-versus-autumn-grass-clover-silage-and-rapeseed-supplementation-on-milk-production-composition-and-quality-in-jersey-cows
#18
Mette Krogh Larsen, Stefania Vogdanou, Anne Louise F Hellwing, Iga Rybicka, Martin Riis Weisbjerg
The composition of grass/clover silage varies depending on time of harvest time. In particular silage from late regrowths is expected to contain lower fibre and higher linolenic acid concentrations compared to spring growth, thereby autumn silage is expected to increase linolenic acid content of milk fat. Rapeseed supplementation is expected to increase milk production and to increase all C18 fatty acids in milk fat. An interaction between rapeseed and silage type is expected, as hydrogenation of unsaturated fatty acids in rapeseed is expected to be less when low fibre silage is fed...
November 2016: Journal of Dairy Research
https://www.readbyqxmd.com/read/27837349/comparison-of-body-composition-and-nutrients-deficiencies-between-portuguese-rink-hockey-players
#19
Maria-Raquel G Silva, Hugo-Henrique Silva
: We evaluated dietary intake and body composition of child and adolescent rink-hockey players and controls. Seventy-two male rink-hockey players (38 children and 34 adolescents) and 79 male controls (43 children and 36 adolescents) were evaluated in order to collect training data, detailed dietary intake and body composition. Rink-hockey players presented significantly lower body fat (BF) and higher fat-free mass (FFM) than controls. Mean intakes of carbohydrate and protein were considered to be adequate, but mean intakes of fat were above the recommended levels in athletes...
November 12, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27836640/transmembrane-topology-of-the-arsenite-permease-acr3-from-saccharomyces-cerevisiae
#20
Donata Wawrzycka, Katarzyna Markowska, Ewa Maciaszczyk-Dziubinska, Magdalena Migocka, Robert Wysocki
Acr3 is a plasma membrane transporter, a member of the bile/arsenite/riboflavin transporter (BART) superfamily, which confers high-level resistance to arsenicals in the yeast Saccharomyces cerevisiae. We have previously shown that the yeast Acr3 acts as a low affinity As(III)/H(+) and Sb(III)/H(+) antiporter. We have also identified several amino acid residues that are localized in putative transmembrane helices (TM) and appeared to be critical for the Acr3 activity. In the present study, the topology of Acr3 was investigated by insertion of glycosylation and factor Xa protease cleavage sites at predicted hydrophilic regions...
November 9, 2016: Biochimica et Biophysica Acta
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