keyword
https://read.qxmd.com/read/38196451/is-tranexemic-acid-really-helpful-in-major-hemorrhage
#1
JOURNAL ARTICLE
Faraz Mansoor
No abstract text is available yet for this article.
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/37935048/retraction-of-pre-operative-tranexemic-acid-vs-etamsylate-in-reducing-blood-loss-during-elective-cesarean-section-randomized-controlled-trial
#2
Haitham Torky, El-Sayed El-Desouky, Ibrahim Abo-Elmagd, Attia Mohamed, Ahmad Abdalhamid, Ashraf El-Shahat, Sileem Ahmed Sileem, Mahmoud M Tawfick, Ashraf Abo-Louz, Ahmed Hussein
No abstract text is available yet for this article.
November 27, 2023: Journal of Perinatal Medicine
https://read.qxmd.com/read/36540452/tranexamic-acid-use-intra-operatively-decreases-the-need-for-blood-transfusions-and-post-operative-edema-in-temporomandibular-joint-surgeries
#3
Bayan Entezari, Larry M Wolford, Daniel C Gunn, Sergio Murillo, Saravanan Ramamoorthy
Temporomandibular joint (TMJ) surgeries cover a vast assortment of surgical procedures such as tooth extractions, tissue biopsies, and extensive maxillofacial surgeries. Major complications that occur during and after TMJ surgeries include uncontrolled bleeding, considerable blood loss, serious infections, and edema. Tranexamic acid (TXA) is an antifibrinolytic agent that reduces blood loss by inhibiting the enzymatic breakdown of fibrin. Currently, TXA is widely used in various orthopedic surgeries to reduce bleeding and decrease the need for blood transfusions...
November 2022: Curēus
https://read.qxmd.com/read/35996031/reducing-transfusion-in-hip-arthroplasty-tranexemic-acid-diminishes-influence-of-anesthesia-administered
#4
JOURNAL ARTICLE
Dylan B Combs, Amelia Hummel, Scott T Nishioka, Samantha N Andrews, Cass K Nakasone
BACKGROUND: The risk of transfusion following total hip arthroplasty (THA) continues to be problematic. The best choice of anesthesia (spinal vs general) and impact of tranexamic acid (TXA) use in reducing transfusions following surgery remain unclear. Therefore, the purpose of this study was to compare rates of blood transfusion following THA via the anterior approach using three different anesthesia protocols with and without TXA. MATERIALS AND METHODS: This retrospective review included 1399 patients (1659 hips), receiving spinal anesthesia (SA) without (248 patients) and with TXA (77 patients), general anesthesia (GA) without (151 patients) and with TXA (171) and general anesthesia with paravertebral block (GA-PVB) and TXA (748 patients)...
June 2023: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/35965904/a-randomized-comparative-study-of-intralesional-tranexemic-acid-and-kligman-s-regimen-in-indian-patients-with-melasma
#5
JOURNAL ARTICLE
Pawan Gupta, Shital Poojary, Lily Dubey
CONTEXT: Melasma is an acquired chronic disorder of hyperpigmentation. Tranexamic acid (TXA) has been shown to be effective in reducing the severity of melasma. AIMS: The aim of this study is to compare the efficacy of intralesional TXA with topical Kligman's regimen in the treatment of facial melasma and to assess their safety profile. SETTINGS AND DESIGN: A double arm open-labeled randomized controlled trial was conducted at a tertiary care center in western India...
2022: Journal of Cutaneous and Aesthetic Surgery
https://read.qxmd.com/read/34137548/oral-tranexemic-acid-with-triple-combination-cream-flucinolone-hydroquinone-tretinoin-versus-triple-combination-cream-alone-in-treatment-of-melasma
#6
RANDOMIZED CONTROLLED TRIAL
Anam Basit, Atiya Rahman, Rehan Uddin
BACKGROUND: Melasma is an acquired cutaneous disorder characterized by hyperpigmentation of the face predominantly affecting the areas exposed to direct sun light. The triple combination cream, i.e., a mid-potency corticosteroid (Fluocinolone acetonide 0.01%), a retinoid (Tretinoin 0.05%), and Hydroquinone 4% is one of the widely used topical medicament for melasma treatment world over. Tranexamic acid is another agent found to be effective in melasma treatment when used topically, intra-lesionally or orally...
2021: Journal of Ayub Medical College, Abbottabad: JAMC
https://read.qxmd.com/read/33844193/topical-tranexemic-acid-reduces-intra-operative-blood-loss-and-transfusion-requirements-in-spinal-deformity-correction-in-patients-with-adolescent-idiopathic-scoliosis
#7
JOURNAL ARTICLE
Stephen George, Subaraman Ramchandran, Alexander Mihas, Kevin George, Ali Mansour, Thomas Errico
PURPOSE: To evaluate the effectiveness of the use of topical tranexamic acid (tTXA) in spinal deformity correction in AIS patients METHODS: Sixty consecutive operative AIS patients were reviewed from a single institution and divided into two groups with similar demographics. Standardized peri-operative blood salvage techniques were utilized in all 60 patients. In the latter 30 patients, tTXA soaked sponges (1 g mixed in 500 ml Normal Saline) was utilised for wound packing during the entire surgical procedure compared to dry sponges as used in the former 30 patients...
September 2021: Spine Deformity
https://read.qxmd.com/read/33425507/effectiveness-of-tranexamic-acid-in-reducing-postoperative-blood-loss-in-patients-undergoing-off-pump-coronary-artery-bypass-grafting
#8
JOURNAL ARTICLE
Prashant Khadanga, Muralidhar Kanchi, Pallavi Gaur
Background Off-pump coronary artery bypass grafting (OP-CABG) is an accepted surgical option in treating ischemic heart disease and has proven safer than traditional on-pump CABG in terms of reducing perioperative bleeding, coagulopathy, avoiding cardiopulmonary bypass machine and its related morbidity. However, there is evidence that shows the risk of bleeding in OP-CABG due to surgical trauma, heart manipulations, and heparin-protamine exposure. We aim to evaluate the effectiveness of tranexamic acid (TxA) in reducing blood loss and related perioperative complications in patients undergoing OP-CABG...
December 5, 2020: Curēus
https://read.qxmd.com/read/33064669/pre-operative-tranexemic-acid-vs-etamsylate-in-reducing-blood-loss-during-elective-cesarean-section-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Haitham Torky, El-Sayed El-Desouky, Ibrahim Abo-Elmagd, Attia Mohamed, Ahmad Abdalhamid, Ashraf El-Shahat, Sileem Ahmed Sileem, Mahmoud M Tawfick, Ashraf Abo-Louz, Ahmed Hussein
OBJECTIVES: To investigate whether etamsylate may be an alternative to tranexamic acid in reduction of blood loss during elective cesarean section. METHODS: Prospective double-blinded multi-center randomized controlled trial involving 180 qualified women equally divided into three groups each containing 60 women received either tranexamic acid, etamsylate or placebo 20 min before elective cesarean section and blood loss was estimated. RESULTS: Mean blood loss, cases needing blood transfusion and cases needing further interventions were significantly lower in tranexamic acid and etamsylate group than placebo group, while mean postoperative hemoglobin and hematocrite were significantly higher in both tranexamic acid and etamsylate as compared to placebo...
March 26, 2021: Journal of Perinatal Medicine
https://read.qxmd.com/read/32189943/is-blood-transfusion-really-required-in-simultaneous-bilateral-total-knee-replacement-a-retrospective-observational-study
#10
REVIEW
Abhishek Vaish, Rupesh Jung Belbase, Raju Vaishya
Simultaneous bilateral TKA (SBTKA) in a single sitting is an attractive option for medically fit patients, with end-stage osteoarthritis (OA) of both the knees. It is a cost-effective procedure but is associated with increased blood loss and requirement for blood transfusion. We present a retrospective observational study of 144 patients who had SBTKA, with the mean age of 63.86 ± 7.38 years. We noted that all the cases of SBTKA would not require a blood transfusion, if the preoperative selection and optimization of the patient is done carefully and with the use of clean surgical technique and adequate thermocoagulation of the bleeders and perioperative use of tranexemic acid (TA) is done in these cases...
March 2020: Journal of Clinical Orthopaedics and Trauma
https://read.qxmd.com/read/31929250/comparison-of-effectiveness-of-tranexamic-acid-and-epsilon-amino-caproic-acid-in-decreasing-postoperative-bleeding-in-off-pump-cabg-surgeries-a-prospective-randomized-double-blind-study
#11
RANDOMIZED CONTROLLED TRIAL
Swapnil Verma, Upadhyayula Srinivas, Anand Kumar Sathpathy, Priyanka Mittal
CONTEXT: Off-pump coronary artery bypass graft (CABG) surgeries have been shown to have increased fibrinolysis due to tissue plasminogen activator release. There are no trials comparing the two available antifibrinolytics (tranexemic acid and epsilon-amino-caproic acid) in off-pump CABG surgeries. AIMS: The aim of the present study was to compare the effectiveness of tranexamic acid and epsilon-amino-caproic acid with respect to postoperative bleeding at 4 and 24 hours as the primary outcome, and rate of postoperative transfusion, re-operations, complication rate, serum fibrinogen, and D-dimer levels as secondary outcomes...
2020: Annals of Cardiac Anaesthesia
https://read.qxmd.com/read/31418256/pre-hospital-environment-bleeding-from-history-to-future-prospects
#12
REVIEW
Bruno Pereira, Alcir Dorigatti, Luis Calderon, Mayara Negrão, Guilherme Meirelles, Juan Duchesne
While the blood was related to life since antiquity, scientific investigations on anatomy and physio-logy of the circulation system had to wait until the arrival of the 16th century. In trauma patients, hemorrhagic shock is the main risk factor for multiple organ dysfunction and consequent increased mortality. On the pre-hospital setting intravenous administration of crystalloid solution became the more common intervention during resuscitation of trauma patient due to many reasons although currently new discussions have blossomed on regards type of fluids and resuscitation...
2019: Anaesthesiology Intensive Therapy
https://read.qxmd.com/read/30446276/a-perspective-on-the-one-year-results-of-the-aspirin-and-tranexemic-acid-for-coronary-artery-surgery-trial
#13
EDITORIAL
John Bozinovski
No abstract text is available yet for this article.
February 2019: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/30253023/efficacy-of-oral-tranexemic-acid-in-refractory-melasma-a-clinico-immuno-histopathological-study
#14
JOURNAL ARTICLE
Donthula Nagaraju, Rajsmita Bhattacharjee, Keshavamurthy Vinay, Uma Nahar Saikia, Davinder Parsad, Muthu Sendhil Kumaran
Tranexamic acid (TXA), a plasmin inhibitor, is an antifibrinolytic drug widely used to prevent and treat hemorrhage. We evaluated the effects of oral TXA clinically and immunohistopathologically in patients of refractory melasma. To evaluate the efficacy of oral TXA in patients with refractory melasma and correlate histopathological and immunohistochemical changes in pretreatment and post-treatment skin biopsies in patients willing to undergo biopsy. Thirty patients with refractory melasma were treated with oral TXA 500 mg twice daily along with a sunscreen and followed up...
September 2018: Dermatologic Therapy
https://read.qxmd.com/read/29985230/severely-injured-trauma-patients-with-admission-hyperfibrinolysis-is-there-a-role-of-tranexamic-acid-findings-from-the-proppr-trial
#15
JOURNAL ARTICLE
Muhammad Khan, Faisal Jehan, Eileen M Bulger, Terence OʼKeeffe, John B Holcomb, Charles E Wade, Martin A Schreiber, Bellal Joseph
INTRODUCTION: Administration of tranexamic acid (TXA) in coagulopathy of trauma gained popularity after the CRASH-2 trial. The aim of our analysis was to analyze the role of TXA in severely injured trauma patients with admission hyperfibrinolysis. METHODS: We reviewed the prospectively collected Pragmatic, Randomized Optimal Platelet and Plasma Ratios database. We included patients with admission hyperfibrinolysis (Ly30 >3%) on thromboelastography. Patients were stratified into two groups (TXA and No-TXA) and were matched in 1:2 ratio using propensity score matching for demographics, admission vitals, and injury severity...
November 2018: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/29334569/assessment-of-prehospital-hemorrhage-and-airway-care-using-a-simulation-model
#16
JOURNAL ARTICLE
Mariya E Skube, Seth Witthuhn, Kristine Mulier, Bonnie Boucher, Elizabeth Lusczek, Greg J Beilman
BACKGROUND: The quality of prehospital care impacts patient outcomes. Military efforts have focused on training revision and the creation of high-fidelity simulation models to address potentially survivable injuries. We sought to investigate the applicability of models emphasizing hemorrhage control and airway management to a civilian population. METHODS: Prehospital health care providers (PHPs) undergoing their annual training were enrolled. A trauma scenario was simulated with two modules: hemorrhage control and airway management...
July 2018: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/28790785/a-randomized-control-trial-to-assess-efficacy-of-mifepristone-in-medical-management-of-uterine-fibroid
#17
JOURNAL ARTICLE
D Arora, Jaya Chawla, S P S Kochar, J C Sharma
BACKGROUND: Fibroids are the most common benign tumours of uterus. Heavy menstrual bleeding is the commonest concern for which medical attention is sought. Hysterectomies for leiomyoma constitute a third of all hysterectomies. Thus, healthcare cost to society due to uterine leiomyomas is of considerable importance. METHODS: A prospective study was conducted at tertiary care hospital of armed forces. 120 women in pre-menopausal age group with complaints of menorrhagia, Pictorial Bleeding Assessment Chart (PBAC) scoring ≥100 and at least one fibroid ≥2...
July 2017: Medical Journal, Armed Forces India
https://read.qxmd.com/read/28553440/prospective-study-to-compare-intra-articular-versus-intravenous-tranexemic-acid-in-reducing-post-operative-blood-loss-in-staged-bilateral-total-knee-arthroplasty
#18
JOURNAL ARTICLE
N Balasubramanian, G B Natarajan, S Prakasam
The number of total knee arthroplasties (TKA) performed is around two million annually worldwide and this number is expected to increase fivefold by 2025. The most common indication is osteoarthritis of the knee. Blood loss is significant during the post-operative period and blood transfusion when necessary has its own drawbacks. The use of intravenous tranexamic acid has significantly reduced blood loss. We analysed 35 patients who underwent staged bilateral TKA between August 2013 and February 2016 and had administered intra-articular tranexamic acid for one knee and intravenous tranexamic acid for the other knee...
November 2016: Malaysian Orthopaedic Journal
https://read.qxmd.com/read/27343711/using-tranexamic-acid-soaked-absorbable-gelatin-sponge-following-complex-posterior-lumbar-spine-surgery-a-randomized-control-trial
#19
RANDOMIZED CONTROLLED TRIAL
Jinqian Liang, Hongzhe Liu, Xiangwang Huang, Wei Xiong, Hong Zhao, Sooyong Chua, Zheng Li
OBJECTIVES: This paper aims to determine whether the use of Tranexemic Acid (TXA) - soaked absorbable gelatin sponge could more effectively reduce post-operative blood loss and blood transfusion requirements among low-risk adult patients undergoing lumbar spine surgery. METHODS: A total of 90 consecutive patients undergoing surgery for multilevel posterior lumbar degenerative procedures were prospectively randomized into one of three groups: - TXA Soaked Gelfoam group, absorbable gelatin sponge group or control group...
August 2016: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/24133333/acute-arterial-thrombosis-associated-with-inadvertent-high-dose-of-tranexamic-acid
#20
Surjya Prasad Upadhyay, Piyush N Mallick, Manish Jagia, Raj Kumar A Singh
Tranexamic acid (TA) act as anti-fibrinolytic agent and is widely used to limit bleeding in clinical practice. Tranexemic acid bind with plasminogen and prevent its conversion to plasmin, which limits the fibrinolytic pathway, so there is a theoretical risk of increasing thrombosis with high or prolonged therapy with TA. We encountered a case of acute arterial thrombosis following inadvertent administration of high dose of TA. A 27-years-old male with no other co-morbidity was ordered intravenous 1 gm TA to control excessive bleeding from previous bladder injury, but by mistake, he received 10 gm of TA...
July 2013: Indian Journal of Critical Care Medicine
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