Ma Chenglong, He Yanan, Wang Huan, Chang Xu, Qi Chelimuge, Feng Yuanzhou, Cai Xiaoxu, Bai Meirong, Wang Xueyan, Zhao Baoquan, Dong Wu
Gelsemium elegans (GE), also known as Duanchangcao, is a plant associated with toxic symptoms related to the abdomen; however, the toxicity caused by GE remains unknown. Gelsemine (GEL) is an alkaloid extracted from GE and is one of the most toxic alkaloids. This study used zebrafish as an animal model and employed high-throughput gene sequencing to identify genes and signaling pathways related to GEL toxicity. Exposure to GEL negatively impacted heart rate, swim bladder development, and activity in zebrafish larvae...
March 4, 2024: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP