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https://www.readbyqxmd.com/read/27882774/usefulness-of-copeptin-as-a-potential-biomarker-in-tbe
#1
Piotr Czupryna, Anna Moniuszko-Malinowska, Adam Garkowski, Justyna Dunaj, Renata Swierzbinska, Sławomir Pancewicz, Joanna Gościk, Maciej Kondrusik, Sambor Grygorczuk, Joanna Zajkowska
OBJECTIVE: The aim of the study was the evaluation of copeptin usefulness for differentiation of hyponatremia in the course of tick-borne encephalitis (TBE) and for being a prognostic marker of the severity of TBE. MATERIALS AND METHODS: 114 patients with TBE were included in the study. The control group consisted of 62 patients diagnosed with viral meningitis. RESULTS: Copeptin concentration did not differ in patients with hyponatremia and normonatremia...
November 24, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27857840/tolvaptan-use-during-hyperhydration-in-paediatric-intracranial-lymphoma-with-siadh
#2
Ruben H Willemsen, Violeta Delgado-Carballar, Daniela Elleri, Ajay Thankamony, G A Amos Burke, James C Nicholson, David B Dunger
: An 11-year-old boy developed severe syndrome of inappropriate antidiuretic hormone secretion (SIADH) after diagnosis of an intracranial B-cell lymphoma. His sodium levels dropped to 118-120 mmol/L despite 70% fluid restriction. For chemotherapy, he required hyperhydration, which posed a challenge because of severe hyponatraemia. Tolvaptan is an oral, highly selective arginine vasopressin V2-receptor antagonist, which has been licensed in adults for the management of SIADH and has been used in treating paediatric heart failure...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27857838/hyponatraemia-secondary-to-nivolumab-induced-primary-adrenal-failure
#3
Harris Trainer, Paul Hulse, Claire E Higham, Peter Trainer, Paul Lorigan
: Checkpoint inhibitors, such as ipilimumab and pembrolizumab, have transformed the prognosis for patients with advanced malignant melanoma and squamous non-small-cell lung cancer, and their use will only expand as experience is gained in a variety of other malignancies, for instance, renal and lymphoma. As the use of checkpoint inhibitors increases, so too will the incidence of their unique side effects, termed immune-related adverse events (irAEs), which can affect dermatological, gastrointestinal, hepatic, endocrine and other systems...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27857783/hyponatremia-in-children-with-tuberculous-meningitis-a-hospital-based-cohort-study
#4
Prithi Inamdar, Sanjeevani Masavkar, Preeti Shanbag
BACKGROUND: Hyponatremia has long been recognized as a potentially serious metabolic consequence of tuberculous meningitis (TBM) occurring in 35-65% of children with the disease. The syndrome of inappropriate antidiuretic hormone (SIADH) secretion has for long been believed to be responsible for the majority of cases of hyponatremia in TBM. Cerebral salt wasting syndrome (CSWS) is being increasingly reported as a cause of hyponatremia in some of these children. AIM: This study was done to determine the frequency and causes of hyponatremia in children with TBM...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27851619/1985-rapid-onset-of-siadh-induced-by-exogenous-vasopressin-use
#5
Vivian Chan
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27776720/identifying-different-causes-of-hyponatremia-with-fractional-excretion-of-uric-acid
#6
Louis J Imbriano, Joseph Mattana, James Drakakis, John K Maesaka
BACKGROUND: There is controversy over the prevalence of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and cerebral or renal salt wasting (RSW), 2 syndromes with identical common clinical and laboratory parameters but different therapies. The traditional approach to the hyponatremic patient relies on volume assessment, but there are limitations to this method. METHODS: We used an algorithm that relies on fractional excretion of urate (FEurate) to evaluate patients with hyponatremia and present 4 illustrative cases...
October 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27756039/takotsubo-cardiomyopathy-in-a-patient-with-siadh
#7
Kunal Kishor Jha, Manoj Kumar, Utpal Jha, Sabina Desar
No abstract text is available yet for this article.
October 11, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27752466/successful-treatment-of-sepsis-due-to-pantoea-agglomerans-by-polymyxin-b-immobilized-fiber-column-direct-hemoperfusion-therapy-in-a-small-cell-lung-carcinoma-patient
#8
Hironobu Tsubouchi, Nobuhiro Matsumoto, Shigehisa Yanagi, Yasuji Arimura, Masamitsu Nakazato
Sepsis is a life-threatening condition caused by the inflammatory response to invading organisms. Polymyxin B-immobilized fiber column direct hemoperfusion (PMX-DHP) is used to reduce blood endotoxin levels and modulate circulating inflammatory cytokine levels in sepsis patients. Here we report that severe sepsis caused by an infection of the gram-negative bacterium Pantoea agglomerans in a patient with small cell lung carcinoma was treated successfully with antibiotics and PMX-DHP. The patient, a 49-year-old Japanese male smoker whose condition was complicated with hyponatremia due to SIADH (syndrome of inappropriate secretion of antidiuretic hormone), rapidly developed sepsis and disseminated intravascular coagulation (DIC) after the administration of cisplatin and irinotecan...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27721999/paliperidone-inducing-concomitantly-syndrome-of-inappropriate-antidiuretic-hormone-neuroleptic-malignant-syndrome-and-rhabdomyolysis
#9
Jaspinder Kaur, Dileep Kumar, Mostafa Alfishawy, Ricardo Lopez, Issac Sachmechi
Paliperidone, an active metabolite of risperidone, is a new atypical antipsychotic agent. Syndrome of inappropriate antidiuretic hormone (SIADH), neuroleptic malignant syndrome (NMS), and rhabdomyolysis are the uncommon side effects of psychotropic drugs. We report a case of 35-year-old male with schizoaffective disorder who was admitted for acute-on-chronic exacerbation of his psychotic disorder for which intramuscular paliperidone 234 mg injection was given. Two days later, the patient developed hyponatremic seizures secondary to SIADH which was treated with hypertonic saline...
2016: Case Reports in Critical Care
https://www.readbyqxmd.com/read/27716174/erratum-to-syndrome-of-inappropriate-secretion-of-antidiuretic-hormone-siadh-associated-with-lateral-medullary-syndrome-case-report-and-literature-review
#10
Hiroto Nakano, Daisuke Yanase, Masahito Yamada
No abstract text is available yet for this article.
October 3, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27701711/filling-the-gap-improving-awareness-and-practice-in-hyponatraemia-and-the-syndrome-of-inappropriate-antidiuretic-hormone-secretion-siadh-in-the-older-patient-a-european-consensus-view
#11
M Wehling, C Ashton, E Ekpo, S Gwynn, M Laville, K Olsson, M Spring
Introduction: Causes of hyponatraemia in older patients are multivariate and in the case of SIADH may often be drug induced. Diagnostic and treatment algorithms are unclear for this important age group. Methods: The author group identified 6 broad themes for consensus and formulated 42 separate consensus statements within these 6 themes. Statements were then circulated to geriatricians, general practitioners and other doctors to test agreement at the European level. Results: 64 responses were evaluated from around Europe...
October 4, 2016: Drug Research
https://www.readbyqxmd.com/read/27663264/surgical-results-of-pure-endoscopic-endonasal-transsphenoidal-surgery-for-331-pituitary-adenomas-an-experience-of-a-single-institute-for-15-years
#12
Ji Hwan Jang, Kyu Hong Kim, Young Min Lee, Joon Soo Kim, Young Zoon Kim
BACKGROUND: The aim of this study is to report the results of pure endoscopic endonasal transsphenoidal surgeries (EETSS) for pituitary adenomas (PAs) and to evaluate the efficacy and safety of this procedure. Additionally, we tried to determine the predicting factors for progression of PAs. METHODS: We reviewed the medical records of 331 consecutive patients who underwent pure EETSS of newly diagnosed PAs between April 1998 and December 2014. Demographic, endocrinological, and radiological features and their outcomes, complications, and hospital stay durations were retrospectively assessed in these patients...
September 20, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27646495/prospective-study-of-hypothalamo-hypophyseal-dysfunction-in-children-and-adolescents-following-traumatic-brain-injury
#13
David Krahulik, Darina Aleksijevic, Vratislav Smolka, Eva Klaskova, Petra Venhacova, Miroslav Vaverka, Vladimir Mihal, Jirina Zapletalova
BACKGROUND AND AIMS: Retrospective studies of TBI have found a neuroendocrine dysfunction following traumatic brain injury in 23 to 60% of adults and 15 to 21% of children. Our aims were to determine the prevalence of hypothalamo-hypophyseal dysfunction in children following brain injury, assess its relationship to the type of injury and the course of the acute post-traumatic phase. PATIENTS AND METHODS: Body development (growth, pubertal development, and skeletal maturity) were evaluated in 58 patients (21 girls) after a brain injury rated 3 to 12 on the Glasgow Coma Scale (GCS)...
September 19, 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/27635269/siadh-induced-by-pharyngeal-squamous-cell-carcinoma-case-report-and-literature-review
#14
Hafiz Muhammad Sharjeel Arshad, Aleida Rodriguez, Faten Suhail
Background. The Syndrome of Inappropriate Antidiuretic Hormone (SIADH) is considered to be the most common cause of euvolemic hyponatremia. The most common malignancy associated with SIADH is small cell lung cancer. We present a rare case of a patient with SIADH secondary to well differentiated squamous cell carcinoma of the naso-oropharynx. Case. A 46-year-old Caucasian woman presented to emergency department with four-week history of progressive dysphagia. On examination, she was found to have a pharyngeal mass...
2016: Case Reports in Nephrology
https://www.readbyqxmd.com/read/27590789/the-syndrome-of-inappropriate-secretion-of-anti-diuretic-hormone-siadh-and-brucellosis
#15
Keziban Aslı Bala, Murat Doğan, Sultan Kaba, Sinan Akbayram, Oktay Aslan, Selami Kocaman, Gülsüm İclal Bayhan, Lokman Üstyol, Nihat Demir
BACKGROUND Our study aimed to demonstrate the frequency of the syndrome of inappropriate ADH secretion (SIADH) and associated factors during the course of brucellosis in children and adolescents. MATERIAL AND METHODS The study included children and adolescents aged 0-18 years old diagnosed with brucellosis between 2012 and 2014. The data were collected from patient charts. The diagnosis of brucellosis was made based on titrations >1:160 in standard Wright tube agglutination tests and/or positive culture tests...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27579188/a-novel-t55a-variant-of-gs-%C3%AE-associated-with-impaired-camp-production-bone-fragility-and-osteolysis
#16
Kelly Wentworth, Alyssa Hsing, Ashley Urrutia, Yan Zhu, Andrew E Horvai, Murat Bastepe, Edward C Hsiao
G-protein coupled receptors (GPCRs) mediate a wide spectrum of biological activities. The GNAS complex locus encodes the stimulatory alpha subunit of the guanine nucleotide binding protein (Gsα) and regulates production of the second messenger cyclic AMP (cAMP). Loss-of-function GNAS mutations classically lead to Albright's Hereditary Osteodystrophy (AHO) and pseudohypoparathyroidism, often with significant effects on bone formation and mineral metabolism. We present the case of a child who exhibits clinical features of osteolysis, multiple childhood fractures, and neonatal SIADH...
2016: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/27569354/-severe-hyponatremia-after-cisplatin-based-chemotherapy-two-case-reports
#17
Mari Ohtaka, Yusuke Hattori, Yohei Kumano, Yoko Maeda, Takuya Kondo, Taku Mochizuki, Takashi Kawahara, Jun-Ichi Teranishi, Yasuhide Miyoshi, Yasushi Yumura, Hiroji Uemura
Hyponatremia is one of the common electrolyte disorders associated with cisplatin (CDDP) administration. We report here two cases of hyponatremia associated with CDDP. Case 1 : A 75-year-old man with urothelial carcinoma of bladder (cT3N1M0) underwent neoadjuvant chemotherapy with CDDP and gemcitabine. He lost consciousness on the eighth day after the chemotherapy. Blood tests showed severe hyponatremia (Na 113 mEq/l), low plasma osmolality and high level of plasma vasopressin. Urine tests showed low osmolality...
July 2016: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/27478556/enteroviral-meningitis-in-neonates-and-children-of-mashhad-iran
#18
Mohammad Javad Ghabouli Shahroodi, Kiarash Ghazvini, Reza Sadeghi, Mohammad Saeed Sasan
BACKGROUND: The highest incidence of meningitis occurs during the neonatal period and (then) infancy. Although Bacterial agents are the most dangerous cause of neonatal and childhood meningitis yet viruses especially, enteroviruses (EV), are by far the most common cause of meningitis in this age group. OBJECTIVES: The aim of the current study was to evaluate the role of EVs in neonatal and childhood meningitis in the Mashhad city of Iran. MATERIALS AND METHODS: This was a descriptive study that was performed at Imam Reza hospital in a period of six months (March to September 2007), during which all of the cerebral spinal fluid (CSF) samples from the neonatal intensive care unit (NICU) and pediatrics ward were collected and real time-polymerase chain reaction (RT-PCR) for EVs was done on these samples...
May 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27461339/syndrome-of-inappropriate-secretion-of-antidiuretic-hormone-siadh-associated-with-lateral-medullary-syndrome-case-report-and-literature-review
#19
Hiroro Nakano, Daisuke Yanase, Masahito Yamada
BACKGROUND: Only one case of syndrome of inappropriate secretion of antidiuretic hormone with lateral medullary syndrome has been reported so far. We report a case of lateral medullary syndrome showing syndrome of inappropriate secretion of antidiuretic hormone and analyze the pathomechanism underlying its clinical features. CASE PRESENTATION: A 67-year-old man was admitted to our hospital for dizziness, dysarthria, and dysphagia. He was diagnosed with lateral medullary syndrome based on the neurological examination and brain magnetic resonance imaging...
July 27, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27438797/early-effects-of-enteral-urea-on-intracranial-pressure-in-patients-with-acute-brain-injury-and-hyponatremia
#20
Filippo Annoni, Vito Fontana, Serge Brimioulle, Jacques Creteur, Jean-Louis Vincent, Fabio S Taccone
BACKGROUND: Hyponatremia occurs commonly after acute brain injury and is often due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Urea administration is 1 therapeutic option. METHODS: In our Department, enteral urea is routinely administered to patients with acute brain injury who develop hyponatremia consistent with SIADH and do not respond to an initial sodium load. We reviewed the records of all patients over a 2-year period, who had acute brain injury, received enteral urea because of hyponatremia, and had intracranial pressure (ICP) monitoring using an intraventricular catheter...
July 19, 2016: Journal of Neurosurgical Anesthesiology
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