Read by QxMD icon Read


Hendrik Berth, Philipp Matthias Rohleder
INTRODUCTION: The emergency service is a challenging field of activity. The Effort-Reward Imbalance model explains on the basis of the ratio between reward/effort the appearance of occupational stress. For the first time, this study examines the extent of Effort-Reward Imbalance in rescue services in Germany. METHODS: Full-time emergency service employees of a German Red Cross District Association were consulted. N=82 employees (78.8%) participated (M age=37.78 years, 73...
July 19, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
Yvan Hutin, Muazzam Nasrullah, Philippa Easterbrook, Boniface Dongmo Nguimfack, Esteban Burrone, Francisco Averhoff, Marc Bulterys
Worldwide, an estimated 257 million persons are living with chronic hepatitis B virus (HBV) infection (1). To achieve the World Health Organization (WHO) goals for elimination of HBV infection worldwide by 2030, defined by WHO as 90% reduction in incidence and 65% reduction in mortality, access to treatment will be crucial. WHO estimated the care cascade* for HBV infection, globally and by WHO Region. The patent and licensing status of entecavir and tenofovir, two WHO-recommended medicines for HBV treatment, were examined using the Medicines Patent Pool MedsPaL† database...
July 20, 2018: MMWR. Morbidity and Mortality Weekly Report
Paula Jimenez-Fonseca, Sebastian Krug, Gianluca Tamagno, F Fierro Maya, A Monleon Getino, C I Rodriguez Casado, Frederico Costa, Wouter W de Herder, Henning Jann
<br>Pancreatic neuroendocrine tumours (pNETs) represent rare neoplasms of all NETs often presenting without functional activity. Many sporadic non-functioning pNET patients are already metastatic at the time of diagnosis, and the therapeutic approach to such patients is mostly palliative. In this international, multicenter, retrospective cohort study we assessed the prognostic value of a set of anthropometric, clinical, biochemical, radiological, and pathological parameters at baseline and the impact of the therapeutic strategies on the survival of patients with sporadic grade 1/2, stage IV, non-functioning pNETs...
July 19, 2018: Neuroendocrinology
Elizabeth Sweet
The need to more explicitly incorporate political economy and neoliberalism into research on social inequalities in health has been acknowledged across disciplines. This paper explores neoliberalism as it relates to consumer financial debt and internalized feelings of personal responsibility and failure for adults in Boston, Massachusetts. Using data from a mixed-methods study (n = 286), findings show that endorsing a neoliberalized view of personal debt as failure is associated with significantly worse health across a range of measures, including blood pressure, adiposity, self-reported physical and emotional symptoms, depression, anxiety, and perceived stress, even when controlling for several socio-demographic confounders...
July 16, 2018: Social Science & Medicine
Dominique Belpomme, Lennart Hardell, Igor Belyaev, Ernesto Burgio, David O Carpenter
Exposure to low frequency and radiofrequency electromagnetic fields at low intensities poses a significant health hazard that has not been adequately addressed by national and international organizations such as the World Health Organization. There is strong evidence that excessive exposure to mobile phone-frequencies over long periods of time increases the risk of brain cancer both in humans and animals. The mechanism(s) responsible include induction of reactive oxygen species, gene expression alteration and DNA damage through both epigenetic and genetic processes...
July 6, 2018: Environmental Pollution
Alexandra Perrot, Carole Castanier, Pauline Maillot, Haifa Zitari
INTRODUCTION: Among the tools assessing fall related self-efficacy, the Modified-Falls Efficacy Scale (M-FES) seems to be a comprehensive and sensitive scale. However, no validated French version exists to this day. OBJECTIVE: This study aims to translate the M-FES and validate this French translation (M-FES Fr). METHOD: The validation steps used to translate and validate the M-FES Fr were i) forward - backward translation, ii) examination of the internal structure and reliability, iii) evaluation of the convergent validity...
July 4, 2018: Archives of Gerontology and Geriatrics
Katrine Bjune, Hilde Sundvold, Trond P Leren, Soheil Naderi
BACKGROUND AND AIMS: Induction of low-density lipoprotein receptor (LDLR) plays a significant role in reduction of plasma LDL-cholesterol (LDL-C) levels. Therefore, strategies that enhance the protein level of LDLR provide an attractive therapeutic target for the treatment of hypercholesterolemia. With this aim in mind, we concentrated our effort on studying the role of AKT kinase in regulation of LDLR levels and proceeded to examine the effect of MK-2206, an allosteric and highly selective AKT inhibitor, on LDLR expression...
July 7, 2018: Atherosclerosis
Friederike Erdmann, Tengfei Li, George Luta, Brenda M Giddings, Guillermo Torres Alvarado, Eva Steliarova-Foucher, Joachim Schüz, Ana M Mora
BACKGROUND: Estimating childhood cancer incidence globally is hampered by a lack of reliable data from low- and middle-income countries. Costa Rica is one of the few middle-income countries (MIC) with a long-term high quality nationwide population-based cancer registry. METHODS: Data on incident cancers in children aged under 15 years reported to the Costa Rica National Cancer Registry between 2000 and 2014 were analyzed by diagnostic group, age, sex, and geographical region and compared with incidence data for Hispanic and Non-Hispanic White (NHW) children in California, USA...
July 16, 2018: Cancer Epidemiology
Marine Roulier, Maïté Bueno, Yves Thiry, Frédéric Coppin, Paul-Olivier Redon, Isabelle Le Hécho, Florence Pannier
Radioiodine is of health concerns in case of nuclear events. Possible pathways and rates of flow are essential information for risk assessment. Forest ecosystems could influence the global cycle of long-lived radioiodine isotope (129 I) with transfer processes similar to stable isotope (127 I). Understanding iodine cycling in forest involves study of the ecosystem as a whole. In this context, we determined the 127 I contents and distribution in soil, tree compartments and atmospheric inputs during a three years in situ monitoring of a temperate beech forest stand...
July 16, 2018: Science of the Total Environment
Jonathan Labriola, Yifan Zhou, Bhushan Nagar
Bacterial effector proteins are essential for the infection and proliferation of pathogenic bacteria through manipulation of host immune response pathways. AvrA is a Salmonella effector belonging to the YopJ family of acetyltransferases, which suppresses c-JUN N-terminal kinase (JNK) signaling in mammals through acetylation of mitogen activated receptor kinase kinase 4/7 (MKK4/7). Interestingly, two paralogues of AvrA exist that differ by only a single internal leucine residue, which when absent (AvrA∆L140), abrogates the ability to suppress JNK signaling...
July 19, 2018: Biochemistry
Pierre Kuhn, Jacques Sizun, Charlotte Casper
AIM: Hospitalised newborn infants may be stressed due to inappropriate sensory stimuli and early separation from their families, that can negatively impact their neurodevelopment. The French Group of Reflection and Evaluation of the Environment of Newborns (GREEN) issues guidelines based on environmental neonatology and family centred care. The first recommendation focuses on private family rooms versus large shared rooms. METHODS: These guidelines are based on a systematic evaluation of the literature providing different grades of evidence...
July 19, 2018: Acta Paediatrica
Lilliana Moreno, Michelle Galusha, Rebecca Just
Massively parallel sequencing (MPS) provides forensic DNA laboratories an option to overcome the limitations associated with capillary electrophoresis (CE) and current STR assays. Verogen's MPS ForenseqTM DNA Signature kit concomitantly amplifies 27 autosomal, 7 X-, and 24 Y-STRs. In addition, 94 identity, 56 ancestry, and 22 phenotypic-informative SNPs are included for a total of over 200 markers in one multiplex. An internal validation of this platform was conducted using reference samples to investigate whether the Forenseq™ DNA Signature Prep kit, specifically primer panel B, has the capability to provide consistent and accurate typing/sequencing data...
July 19, 2018: Electrophoresis
Kelvin Yi Chong Teo, Shu Yen Lee, Amutha Veluchamy Barathi, Sai Bo Bo Tun, Licia Tan, Ian Jeffery Constable
Purpose: To determine if the surgical removal of the internal limiting membrane (ILM) in nonhuman primates (NHPs) will result in safe and effective transfection of adeno-associated viral (AAV2) vectors using green fluorescent protein (GFP) as a reporter. Methods: Six Macaca fascicularis NHP eyes underwent vitrectomy, ILM peel with layering of 1.7 × 1013 genome copies per milliliter of AAV2-GFP under air. Four control eyes underwent only vitrectomy and pooling under air...
July 2, 2018: Investigative Ophthalmology & Visual Science
Mulusew Fikere, Denise M Barbulescu, Michelle M Malmberg, Fan Shi, Joshua C O Koh, Anthony T Slater, Iona M MacLeod, Phillip J Bowman, Phillip A Salisbury, German C Spangenberg, Noel O I Cogan, Hans D Daetwyler
Genomic prediction is becoming a popular plant breeding method to predict the genetic merit of lines. While some genomic prediction results have been reported in canola, none have been evaluated for blackleg disease. Here, we report genomic prediction for seedling emergence, survival rate, and internal infection), using 532 Spring and Winter canola lines. These lines were phenotyped in two replicated blackleg disease nurseries grown at Wickliffe and Green Lake, Victoria, Australia. A transcriptome genotyping-by-sequencing approach revealed 98,054 single nucleotide polymorphisms (SNPs) after quality control...
July 2018: Plant Genome
George Alexandre de Barros Lucena, Rafael Scaf de Molon, Antonio J Moretti, Jamil Awad Shibli, Delane Maria Rêgo
PURPOSE: The objective of this investigation was to assess the microbiologic contamination in the inner surface of titanium implants prior to prosthetic abutment placement. MATERIALS AND METHODS: The study population consisted of partially edentulous individuals who had previously received at least one internal hexagon titanium dental implant. A bacterial sample of the inner surface of the individual dental implant was taken after surgical reopening for healing abutment placement...
July 2018: International Journal of Oral & Maxillofacial Implants
Lucia Fernandez-Estevan, Javier Montero, Eduardo J Selva Otaolaurruchi, Maria Fernanda Sola Ruiz
PURPOSE: To quantify the rate of maintenance interventions of mandibular prostheses: complete dentures and overdentures retained by two implants, with either internal hex or external hex connections. MATERIALS AND METHODS: This study analyzed patients with edentulous mandibles treated with distinct treatment protocols: a control group received complete dentures; a second group received Locator-retained overdentures supported by two external hex connection implants; and a third group received overdentures supported by internal hex connection implants...
July 2018: International Journal of Oral & Maxillofacial Implants
Peter Gehrke, Thorsten Sing, Carsten Fischer, Sebastian Spintzyk, Jürgen Geis-Gerstorfer
PURPOSE: Central manufacturing of two-piece computer-aided design/computer-aided manufacture (CAD/CAM) zirconia abutments may provide a higher accuracy of internal and external adaptation at the expense of delayed restoration delivery. The aim of this study was to compare the fit of two-part zirconia abutments that were either fabricated centrally with the DEDICAM system or at a local laboratory. The field of interest was the marginal, external, and internal luting gap between the titanium insert and CAD/CAM zirconia coping...
July 2018: International Journal of Oral & Maxillofacial Implants
Matteo Fallico, Andrea Russo, Antonio Longo, Alfredo Pulvirenti, Teresio Avitabile, Vincenza Bonfiglio, Niccolò Castellino, Gilda Cennamo, Michele Reibaldi
BACKGROUND: Internal limiting membrane (ILM) peeling during primary vitrectomy for rhegmatogenous retinal detachment (RRD) prevents the formation of postoperative macular epiretinal membrane (ERM). However, studies that compared vitrectomy with and without ILM peeling for RRD, have reported controversial outcomes. OBJECTIVE: To assess the efficacy of ILM peeling versus non-ILM peeling during vitrectomy for RRD by a systematic review and meta-analysis of published studies...
2018: PloS One
Zhihuai Yu, Xiu Wang, Huiyang Bian, Liang Jiao, Weibing Wu, Hongqi Dai
The continuous development of high electrical equipment towards high power output requires better heat dissipation performance of internal insulation structure. It challenges the traditional paper-based insulating materials, with poor thermal conductivity. Introducing thermally conductive and electrically insulating filler into cellulose-based insulating material can enhance heat conduction performance. This work provided a method to prepare thermally conductive and electrically insulating BN/cellulosic fibre composites...
2018: PloS One
S Orlando, I Triulzi, F Ciccacci, I Palla, L Palombi, M C Marazzi, M Giuliano, M Floridia, S Mancinelli, E Mutemba, G Turchetti
BACKGROUND: Tuberculosis (TB) represents the ninth leading cause of death worldwide. In 2016 are estimated 1.3 million TB deaths among HIV negative people and an additional 374,000 deaths among HIV positive people. In 2016 are estimated 1.4 million new cases of TB in people living with HIV (PLHIV), 74% of whom were living in Africa. In light of these data, the reduction of mortality caused by TB in PLHIV is strongly required specially in low-income countries as Mozambique. According to international guidelines, the initial TB screening in HIV+ patients should be done with the four symptoms screening (4SS: fever, current cough, night sweats and weight loss)...
2018: PloS One
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"