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https://www.readbyqxmd.com/read/29792210/quantitative-cardiovascular-magnetic-resonance-extracellular-volume-native-t1-and-18f-fdg-pet-cmr-imaging-in-patients-after-revascularized-myocardial-infarction-and-association-with-markers-of-myocardial-damage-and-systemic-inflammation
#1
Karl P Kunze, Ralf J Dirschinger, Hans Kossmann, Franziska Hanus, Tareq Ibrahim, Karl-Ludwig Laugwitz, Markus Schwaiger, Christoph Rischpler, Stephan G Nekolla
BACKGROUND: Characterization of tissue integrity and inflammatory processes after acute myocardial infarction (AMI) using non-invasive imaging is predictive of patient outcome. Quantitative cardiovascular magnetic resonance (CMR) techniques such as native T1 and extracellular volume (ECV) mapping as well as 18 F-FDG positron emission tomography (PET) imaging targeting inflammatory cell populations are gaining acceptance, but are often applied without assessing their quantitative potential...
May 24, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29790857/attenuation-correction-for-brain-pet-imaging-using-deep-neural-network-based-on-dixon-and-zte-mr-images
#2
Kuang Gong, Jaewon Yang, Kyungsang Kim, Georges El Fakhri, Youngho Seo, Quanzheng Li
Positron Emission Tomography (PET) is a functional imaging modality widely used in neuroscience studies. To obtain meaningful quantitative results from PET images, attenuation correction is necessary during image reconstruction. For PET/MR hybrid systems, PET attenuation is challenging as Magnetic Resonance (MR) images do not reflect attenuation coefficients directly. To address this issue, we present deep neural network methods to derive the continuous attenuation coefficients for brain PET imaging from MR images...
May 23, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29790693/hounsfield-units-from-unenhanced-18f-fdg-pet-ct-are-useful-in-evaluating-supradiaphragmatic-lymph-nodes-in-children-and-adolescents-with-classical-hodgkin-s-lymphoma
#3
Radosław Chaber, Mateusz Łasecki, Justyna Kwaśnicka, Kornelia Łach, Zbigniew Podgajny, Cyprian Olchowy, Urszula Zaleska-Dorobisz
BACKGROUND: The precise identification of the primarily-affected nodal regions in Hodgkin's lymphoma(HL) is essential in determining the stage of the disease and the intensity of chemotherapy and radiotherapy. OBJECTIVES: The aim of this study was to use the degree of X-ray attenuation (XRA) in Hounsfield units(HU) and the lymph node-to-muscle attenuation ratio (LN/M) in computed tomography (CT) unenhancedimaging, routinely performed with 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET),to distinguish HL-affected supradiaphragmatic lymph nodes...
May 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29789994/performance-evaluation-of-a-semi-automated-method-for-18-f-fdg-uptake-in-abdominal-visceral-adipose-tissue
#4
Stefanie A de Boer, Daan S Spoor, Riemer H J A Slart, Douwe J Mulder, Melanie Reijrink, Ronald J H Borra, Gerbrand M Kramer, Otto S Hoekstra, Ronald Boellaard, Marcel J Greuter
PURPOSE: Severity of abdominal obesity and possibly levels of metabolic activity of abdominal visceral adipose tissue (VAT) are associated with an increased risk for cardiovascular disease (CVD). In this context, the purpose of the current study was to evaluate the reproducibility and repeatability of a semi-automated method for assessment of the metabolic activity of VAT using 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography (PET)/x-ray computed tomography (CT)...
May 22, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29789808/the-value-of-18-f-fdg-pet-ct-mathematical-prediction-model-in-diagnosis-of-solitary-pulmonary-nodules
#5
Ling Wang, Yao Chen, Kun Tang, Jie Lin, Hong Zhang
Purpose: To establish an 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) mathematical prediction model to improve the diagnosis of solitary pulmonary nodules (SPNs). Materials and Methods: We retrospectively reviewed 177 consecutive patients who underwent 18 F-FDG PET/CT for evaluation of SPNs. The mathematical model was established by logistic regression analysis. The diagnostic capabilities of the model were calculated, and the areas under the receiver operating characteristic curve (AUC) were compared with Mayo and VA model...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29789510/functioning-mediastinal-paraganglioma-associated-with-a-germline-mutation-of-von-hippel-lindau-gene
#6
Thibault Bahougne, Pauline Romanet, Amira Mohamed, Kevin Caselles, Thomas Cuny, Anne Barlier, Patricia Niccoli
We report the case of a 21-year old woman presenting with high blood pressure and raised normetanephrine levels. Indium-111-pentetreotide single photon-emission computed tomography with computed tomography (SPECT/CT) and 2-deoxy-2-[fluorine-18]fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging showing isolated tracer-uptake by a 2 cm tumor close to the costovertebral angle of the third thoracic vertebra. Thoracic surgery led to normalization of normetanephrine levels. Histological findings were consistent with the presence of a paraganglioma...
May 23, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29788984/f-18-fdg-pet-ct-in-26-patients-with-sapho-syndrome-a-new-vision-of-clinical-and-bone-scintigraphy-correlation
#7
Xiaochuan Sun, Chen Li, Yihan Cao, Ximin Shi, Li Li, Weihong Zhang, Xia Wu, Nan Wu, Hongli Jing, Wen Zhang
BACKGROUNDS: Whole-body bone scintigraphy (WBBS) and MRI are widely used in assessment of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. However, the value of F-18 fluorodeoxyglucose-positron emission tomography/computed tomography (18 F-FDG PET/CT) in SAPHO syndrome was unclear. The aim of this study was to characterize the manifestation of SAPHO syndrome on 18 F-FDG PET/CT and explore its relationship with clinical symptoms and WBBS. METHODS: Twenty-six patients who suffered from SAPHO syndrome and had undergone whole-body 18 F-FDG PET/CT were recruited in Peking Union Medical College Hospital from 2004 to 2016...
May 22, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29788497/a-study-of-the-focal-adhesion-kinase-inhibitor-gsk2256098-in-patients-with-recurrent-glioblastoma-with-evaluation-of-tumor-penetration-of-11c-gsk2256098
#8
Nicholas F Brown, Matthew Williams, Hendrik-Tobias Arkenau, Ronald A Fleming, Jerry Tolson, Li Yan, Jianping Zhang, Lisa Swartz, Rajendra Singh, Kurt R Auger, Laurie Lenox, David Cox, Yvonne Lewis, Christophe Plisson, Graham Searle, Azeem Saleem, Sarah Blagden, Paul Mulholland
Background: GSK2256098 is a novel oral focal adhesion kinase inhibitor. Preclinical studies demonstrate growth inhibition in glioblastoma cell lines. However, rodent studies indicate limited blood-brain barrier penetration. In this expansion cohort within a phase I study, the safety, tolerability, pharmacokinetics and clinical activity of GSK2256098 were evaluated in patients with recurrent glioblastoma. Biodistribution and kinetics of [11C]GSK2256098 were assessed in a sub-study using positron-emission tomography (PET)...
May 17, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29788013/cerebrospinal-fluid-bace1-activity-and-sa%C3%AE-pp%C3%AE-as-biomarker-candidates-of-alzheimer-s-disease
#9
Panagiotis Alexopoulos, Nathalie Thierjung, Timo Grimmer, Marion Ortner, Polychronis Economou, Konstantinos Assimakopoulos, Philippos Gourzis, Antonios Politis, Robert Perneczky
BACKGROUND/AIMS: The utility of β-site amyloid-β precursor protein (AβPP) cleaving enzyme 1 (BACE1) activity and soluble AβPP β (sAβPPβ) levels in cerebrospinal fluid (CSF) in detecting Alzheimer's disease (AD) is still elusive. METHODS: BACE1 activity and sAβPPβ concentration were measured in patients with AD dementia (n = 56) and mild cognitive impairment (MCI) due to AD (n = 76) with abnormal routine AD CSF markers, in patients with MCI with normal CSF markers (n = 39), and in controls without preclinical AD (n = 48)...
May 22, 2018: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/29786852/evolution-of-lobar-abnormalities-of-cerebral-glucose-metabolism-in-41-children-with-drug-resistant-epilepsy
#10
Tuhina Govil-Dalela, Ajay Kumar, Michael E Behen, Harry T Chugani, Csaba Juhász
OBJECTIVE: We analyzed long-term changes of lobar glucose metabolic abnormalities in relation to clinical seizure variables and development in a large group of children with medically refractory epilepsy. METHODS: Forty-one children (25 males) with drug-resistant epilepsy had a baseline positron emission tomography (PET) scan at a median age of 4.7 years; the scans were repeated after a median of 4.3 years. Children with progressive neurological disorders or space-occupying lesion-related epilepsy and those who had undergone epilepsy surgery were excluded...
May 22, 2018: Epilepsia
https://www.readbyqxmd.com/read/29786697/imaging-glutathione-depletion-in-the-rat-brain-using-ascorbate-derived-hyperpolarized-mr-and-pet-probes
#11
Hecong Qin, Valerie N Carroll, Renuka Sriram, Javier E Villanueva-Meyer, Cornelius von Morze, Zhen Jane Wang, Christopher A Mutch, Kayvan R Keshari, Robert R Flavell, John Kurhanewicz, David M Wilson
Oxidative stress is a critical feature of several common neurologic disorders. The brain is well adapted to neutralize oxidative injury by maintaining a high steady-state concentration of small-molecule intracellular antioxidants including glutathione in astrocytes and ascorbic acid in neurons. Ascorbate-derived imaging probes for hyperpolarized 13 C magnetic resonance spectroscopy and positron emission tomography have been used to study redox changes (antioxidant depletion and reactive oxygen species accumulation) in vivo...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29786490/gallium-68-psma-11-pet-mr-imaging-in-patients-with-intermediate-or-high-risk-prostate-cancer
#12
Sonya Youngju Park, Claudia Zacharias, Caitlyn Harrison, Richard E Fan, Christian Kunder, Negin Hatami, Frederik Giesel, Pejman Ghanouni, Bruce Daniel, Andreas M Loening, Geoffrey A Sonn, Andrei Iagaru
Purpose To report the results of dual-time-point gallium 68 (68 Ga) prostate-specific membrane antigen (PSMA)-11 positron emission tomography (PET)/magnetic resonance (MR) imaging prior to prostatectomy in patients with intermediate- or high-risk cancer. Materials and Methods Thirty-three men who underwent conventional imaging as clinically indicated and who were scheduled for radical prostatectomy with pelvic lymph node dissection were recruited for this study. A mean dose of 4.1 mCi ± 0.7 (151.7 MBq ± 25...
May 16, 2018: Radiology
https://www.readbyqxmd.com/read/29783621/-18-f-fdg-pet-ct-in-hodgkin-lymphoma-current-usefulness-and-perspectives
#13
REVIEW
Salim Kanoun, Cedric Rossi, Olivier Casasnovas
Functional imaging using 18-fluorodeoxyglycose ([18 F]FDG) positron emission tomography combined with computed tomography (PET/CT) has become a major imaging modality in Hodgkin lymphoma. This imaging modality allows for a significant improvement in staging, increased sensitivity, which involves differentiating residual tumors from fibrosis during assessment, and highly impacts treatment decisions into new PET-driven strategies. This review presents the main scientific data concerning the current applications of [18 F]FDG-PET/CT in Hodgkin lymphoma at baseline, interim, and the end of treatment evaluation along with the main PET-driven trials for therapeutic decisions...
May 18, 2018: Cancers
https://www.readbyqxmd.com/read/29783001/laparoscopic-extraperitoneal-pelvic-lymph-node-debulking-in-locally-advanced-cervical-cancer
#14
Diaz-Feijoo Berta, Luna-Guibourg Rocio, Cabrera Silvia, Manrique Susana, Gil-Moreno Antonio
OBJECTIVE: To demonstrate the feasibility of laparoscopic extraperitoneal approach for pelvic metastatic lymph node debulking in locally advanced cervical cancer. DESIGN: Surgical video article. Canadian task force Classification III. SETTING: University Hospital PATIENT: A 52 year-old patient presented a stage IIA2 Cervical adenocarcinoma according to FIGO classification. The physical exam reported a 45 mm tumor. Positron emission tomography (PET- CT) was positive for hypermetabolic enlarged lymph nodes in left external iliac region of 1...
May 18, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29782864/are-dopamine-receptor-and-transporter-changes-in-rett-syndrome-reflected-in-mecp2-deficient-mice
#15
Dean F Wong, Mary E Blue, James R Brašić, Ayon Nandi, Heather Valentine, Kirstie H Stansfield, Olivier Rousset, Genila Bibat, Mary E Yablonski, Michael V Johnston, Albert Gjedde, SakkuBai Naidu
In the present study we tested the claim that the dopaminergic dysfunction of Rett Syndrome (RTT) also occurs in Mecp2-deficient mice that serve as a model of the syndrome. We used positron emission tomography (PET) to image dopamine D2 receptors (D2 R) and transporters (DAT) in women with RTT and in Mecp2-deficient mice, and D1 R and D2 R density was measured in postmortem human tissue by autoradiography. Results showed 1) significantly reduced D2 R density in the striatum of women with RTT compared to control subjects...
May 18, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29782653/data-driven-gating-in-pet-influence-of-respiratory-signal-noise-on-motion-resolution
#16
Florian Büther, Iris Ernst, Lynn Johann Frohwein, Joost Pouw, Klaus Peter Schäfers, Lars Stegger
PURPOSE: Data-driven gating (DDG) approaches for positron emission tomography (PET) are interesting alternatives to conventional hardware-based gating methods. In DDG, the measured PET data themselves are utilized to calculate a respiratory signal that is subsequently used for gating purposes. The success of gating is then highly dependent on the statistical quality of the PET data. In this study we investigate how this quality determines signal noise and thus motion resolution in clinical PET scans using a center-of-mass-based (COM) DDG approach, specifically with regard to motion management of target structures in future radiotherapy planning applications...
May 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29782588/ground-glass-pulmonary-nodules-their-significance-in-oncology-patients-and-the-role-of-computer-tomography-and-18f-fluorodeoxyglucose-positron-emission-tomography
#17
Laura Evangelista, Annalori Panunzio, Elena Scagliori, Paolo Sartori
Objective: to determine the clinical significance of ground glass pulmonary nodules, either pure (GGNs) or mixed with the presence of solid component (MPNs), in patients with known pulmonary or extra-thoracic malignancies and to evaluate the role of computed tomography (CT) and positron emission tomography (PET)/CT in their diagnosis and follow-up. Methods: A total of 130 nodules in 68 patients were revealed: 119 GGNs and 11 MPNs. GGN lesions were found in 58 patients, MPNs in eight, and in two cases, both...
2018: European journal of hybrid imaging
https://www.readbyqxmd.com/read/29781364/pet-ct-analysis-of-21-patients-with-breast-cancer-physiological-distribution-of-18-f-choline-and-diagnostic-pitfalls
#18
Fathinul Fikri Ahmad Saad, Mohd Hazeman Zakaria, Bahunu Appanna
Objectives 18 F-choline is a useful tracer for detecting tumours with high lipogenesis. Knowledge of its biodistribution pattern is essential to recognise physiological variants. The aim of this study was to describe the physiologic distribution of 18 F-choline and pitfalls in patients with breast cancer. Methods Twenty-one consecutive patients with breast cancer (10 premenopausal and 11 postmenopausal women; mean age, 52.82 ± 10.71 years) underwent 18 F-choline positron emission tomography (PET)/computed tomography (CT) for staging...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29780876/memory-concerns-in-the-early-alzheimer-s-disease-prodrome-regional-association-with-tau-deposition
#19
Cecily G Swinford, Shannon L Risacher, Arnaud Charil, Adam J Schwarz, Andrew J Saykin
Introduction: Relationship between self- and informant memory concerns and tau aggregation was assessed in adults at risk for Alzheimer's disease (AD). Methods: Regional mean standardized uptake value ratios were extracted from [18 F]flortaucipir positron emission tomography (PET) scans of 82 at-risk adults in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Associations between self- and informant ECog memory scores and tau aggregation were analyzed on both regional and voxelwise bases...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29780869/cross-sectional-and-longitudinal-atrophy-is-preferentially-associated-with-tau-rather-than-amyloid-%C3%AE-positron-emission-tomography-pathology
#20
Brian A Gordon, Austin McCullough, Shruti Mishra, Tyler M Blazey, Yi Su, John Christensen, Aylin Dincer, Kelley Jackson, Russ C Hornbeck, John C Morris, Beau M Ances, Tammie L S Benzinger
Introduction: Structural magnetic resonance imaging is a marker of gray matter health and decline that is sensitive to impaired cognition and Alzheimer's disease pathology. Prior work has shown that both amyloid β (Aβ) and tau biomarkers are related to cortical thinning, but it is unclear what unique influences they have on the brain. Methods: Aβ pathology was measured with [18 F] AV-45 (florbetapir) positron emission tomography (PET) and tau was assessed with [18 F] AV-1451 (flortaucipir) PET in a population of 178 older adults, of which 123 had longitudinal magnetic resonance imaging assessments (average of 5...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
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