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https://www.readbyqxmd.com/read/28819796/simultaneous-eeg-pet-fmri-measurements-in-disorders-of-consciousness-an-exploratory-study-on-diagnosis-and-prognosis
#1
Daniel Golkowski, Katharina Merz, Caroline Mlynarcik, Tobias Kiel, Barbara Schorr, Alex Lopez-Rolon, Mathias Lukas, Denis Jordan, Andreas Bender, Rüdiger Ilg
Previous studies could demonstrate that functional magnetic resonance imaging (fMRI), fludeoxyglucose positron emission tomography (FDG-PET), and electroencephalography (EEG) measures contain information about patients suffering from disorders of consciousness (DOC) and thus improve the clinical diagnosis. Additionally, the technical modalities were able to predict the outcome of patients. However, most studies lack proven reproducibility in a clinical setting. We here applied a standardized combined EEG/fMRI/FDG-PET measurement to a cohort of 20 patients suffering from DOC and focused on parameters that have been demonstrated to contain information about diagnosis and prognosis of these patients...
August 17, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28818992/long-half-life-89-zr-labeled-radiotracers-can-guide-in-suite-percutaneous-molecular-imaging-pet-ct-guided-biopsies-without-reinjection-of-radiotracer
#2
Francois H Cornelis, Jeremy Durack, Neeta Pandit-Taskar, Gary A Ulaner, Jason S Lewis, Michael J Morris, Stephen B Solomon
Rationale: To evaluate the feasibility of in suite Zr89 labeled radiotracer positron emission tomography-computed tomography (PET/CT)-guided biopsies performed without reinjection. Methods: From 2013-2016, 12 patients (7 males, 5 females; mean age 61 years, range 40-75) with suspected metastatic prostate or breast carcinoma on either imaging or biochemical progression underwent 14 percutaneous biopsies after diagnostic PET/CT using (89)Zr labeled radiotracers (mean dose: 180MBq; range: 126-189MBq) targeting prostate specific membrane antigen (PSMA) (n = 7) or human epidermal growth factor receptor 2 (HER2) (n = 5)...
August 17, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28818991/immune-modulation-therapy-and-imaging-workshop-report
#3
Anthony F Shields, Paula Jacobs, Mario Sznol, Michael M Graham, Ronald Germain, Lawrence Lum, Elaine Jaffee, Elisabeth G E de Vries, Sridhar Nimmagadda, Annick D Van den Abbeele, David Leung, Anna M Wu, Elad Sharon, Lalitha K Shankar
A workshop at the National Cancer Institute May 2, 2016 considered the current state of imaging in assessment of immunotherapy. Immunotherapy has shown some remarkable and prolonged responses in the treatment of tumors. However, responses are variable and frequently delayed, complicating the evaluation of new immunotherapy agents and customizing treatment for individual patients. Early anatomic imaging may show that a tumor has increased in size, but this could represent pseudoprogression. Based on imaging, clinicians must decide if they should stop, pause, or continue treatment...
August 17, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28818988/multiregional-tumor-drug-uptake-imaging-by-pet-and-microvascular-morphology-in-end-stage-diffuse-intrinsic-pontine-glioma
#4
Sophie E M Veldhuijzen van Zanten, A Charlotte P Sewing, Arthur van Lingen, Otto S Hoekstra, Pieter Wesseling, Michaël H Meel, Dannis G van Vuurden, Gertjan J L Kaspers, Esther Hulleman, Marianna Bugiani
Inadequate tumor uptake of the vascular endothelial growth factor (VEGF) antibody bevacizumab could explain lack of effect in diffuse intrinsic pontine glioma (DIPG). Methods: By combining data from a positron emission tomography (PET) imaging study using zirconium-89((89)Zr)-labeled bevacizumab and an autopsy study, a 1-on-1 analysis of multiregional in vivo and ex vivo (89)Zr-bevacizumab uptake, tumor histology and vascular morphology in a DIPG patient was performed. Results: In vivo (89)Zr-bevacizumab measurements showed heterogeneity between lesions...
August 17, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28818716/positron-emission-tomography-pet-imaging-of-nicotine-induced-dopamine-release-in-squirrel-monkeys-using-18-f-fallypride
#5
Jennifer E Naylor, Takato Hiranita, Katelin S Matazel, Xuan Zhang, Merle G Paule, Amy K Goodwin
BACKGROUND: Nicotine, the principal psychoactive tobacco constituent, is thought to produce its reinforcing effects via actions within the mesolimbic dopamine (DA) system. The objective of the current study was to examine the effect of nicotine on DA D2/D3 receptor availability in the nonhuman primate brain with the use of the radioligand [(18)F]fallypride and positron emission tomography (PET). METHODS: Ten adult male squirrel monkeys were used in the current study...
August 8, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28818538/impact-of-positron-emission-tomography-and-endoscopic-ultrasound-length-of-disease-difference-on-treatment-planning-in-patients-with-oesophageal-cancer
#6
K G Foley, C Morgan, S A Roberts, T Crosby
AIMS: Treatment decision making and planning in patients with oesophageal cancer are guided by radiological measurement of length of disease (LoD). This study aimed to investigate differences in positron emission tomography (PET) and endoscopic ultrasound (EUS) LoD. Their prognostic significance was also assessed. MATERIALS AND METHODS: LoD was measured from PET and EUS staging investigations by one observer for each modality. Bland-Altman analysis and Wilcoxon signed rank tests assessed agreement and differences in measurements...
August 14, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28818092/associations-of-thyroid-hormone-serum-levels-with-in-vivo-alzheimer-s-disease-pathologies
#7
Hyo Jung Choi, Min Soo Byun, Dahyun Yi, Bo Kyung Sohn, Jun Ho Lee, Jun-Young Lee, Yu Kyung Kim, Dong Young Lee
BACKGROUND: The present study investigated the relationships between thyroid hormone serum levels or thyroid-stimulating hormone (TSH) and two Alzheimer's disease (AD)-specific biomarkers, cerebral amyloid beta (Aβ) burden and glucose metabolism, in AD-signature brain regions in cognitively normal (CN) middle-aged and older individuals. METHODS: This study assessed 148 CN individuals who received comprehensive clinical and neuropsychological assessments that included (11)C-Pittsburgh Compound B (PiB)-positron emission tomography (PET) scans, (18)F-deoxyglucose (FDG)-PET scans, and the quantification of serum triiodothyronine (T3), free T3, free thyroxine (fT4), and TSH levels...
August 17, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28817656/investigation-of-the-halo-artifact-in-68ga-psma-11-pet-mri
#8
Thorsten Heußer, Philipp Mann, Christopher M Rank, Martin Schäfer, Antonia Dimitrakopoulou-Strauss, Heinz-Peter Schlemmer, Boris A Hadaschik, Klaus Kopka, Peter Bachert, Marc Kachelrieß, Martin T Freitag
OBJECTIVES: Combined positron emission tomography (PET) and magnetic resonance imaging (MRI) targeting the prostate-specific membrane antigen (PSMA) with a 68Ga-labelled PSMA-analog (68Ga-PSMA-11) is discussed as a promising diagnostic method for patients with suspicion or history of prostate cancer. One potential drawback of this method are severe photopenic (halo-) artifacts surrounding the bladder and the kidneys in the scatter-corrected PET images, which have been reported to occur frequently in clinical practice...
2017: PloS One
https://www.readbyqxmd.com/read/28816978/prognostic-value-of-18f-fdg-pet-ct-parameters-in-patients-with-pancreatic-carcinoma-a-systematic-review-and-meta-analysis
#9
Dongyong Zhu, Lisha Wang, Hanfei Zhang, Jie Chen, Yanfang Wang, Sama Byanju, Meiyan Liao
BACKGROUND: The identification of pancreatic carcinoma (PC) patients with poor prognosis is a priority in clinical oncology because of their high 5-year mortality. However, the prognostic value of pretreatment F-fluorodeoxyglucose (F-FDG)- positron emission tomography (PET)/computed tomography (CT) parameters in PC patients is controversial and no consensus exists as to its predictive capability. This meta-analysis was performed to comprehensively explore the prognostic significance of F-FDG-PET/CT parameters in patients with pancreatic carcinoma...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816243/dopamine-synthesis-capacity-is-associated-with-d2-3-receptor-binding-but-not-dopamine-release
#10
Anne S Berry, Vyoma D Shah, Daniella J Furman, Robert L White, Suzanne L Baker, James P O'Neil, Mustafa Janabi, Mark D'Esposito, William J Jagust
Positron Emission Tomography (PET) imaging allows the estimation of multiple aspects of dopamine function including dopamine synthesis capacity, dopamine release, and D2/3 receptor binding. Though dopaminergic dysregulation characterizes a number of neuropsychiatric disorders including schizophrenia and addiction, there has been relatively little investigation into the nature of relationships across dopamine markers within healthy individuals. Here we used PET imaging in 40 healthy adults to compare, within individuals, estimates of dopamine synthesis capacity (Ki) using 6-[(18)F]fluoro-l-m-tyrosine ([(18)F]FMT; a substrate for aromatic amino acid decarboxylase), baseline D2/3 receptor binding potential using [(11)C]raclopride (a weak competitive D2/3 receptor antagonist), and dopamine release using [(11)C]raclopride paired with oral methylphenidate administration...
August 17, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28816167/variabilities-of-magnetic-resonance-imaging-computed-tomography-and-positron-emission-tomography-computed-tomography-based-tumor-and-lymph-node-delineations-for-lung-cancer-radiation-therapy-planning
#11
Kishor Karki, Siddharth Saraiya, Geoffrey D Hugo, Nitai Mukhopadhyay, Nuzhat Jan, Jessica Schuster, Matthew Schutzer, Lester Fahrner, Robert Groves, Kathryn M Olsen, John C Ford, Elisabeth Weiss
PURPOSE: To investigate interobserver delineation variability for gross tumor volumes of primary lung tumors and associated pathologic lymph nodes using magnetic resonance imaging (MRI), and to compare the results with computed tomography (CT) alone- and positron emission tomography (PET)-CT-based delineations. METHODS AND MATERIALS: Seven physicians delineated the tumor volumes of 10 patients for the following scenarios: (1) CT only, (2) PET-CT fusion images registered to CT ("clinical standard"), and (3) postcontrast T1-weighted MRI registered with diffusion-weighted MRI...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28815841/response-assessment-after-induction-chemotherapy-for-head-and-neck-squamous-cell-carcinoma-from-physical-examination-to-modern-imaging-techniques-and-beyond
#12
REVIEW
Remco de Bree, Gregory T Wolf, Bart de Keizer, Iain J Nixon, Dana M Hartl, Arlene A Forastiere, Missak Haigentz, Alessandra Rinaldo, Juan P Rodrigo, Nabil F Saba, Carlos Suárez, Jan B Vermorken, Alfio Ferlito
Significant correlations between the response to induction chemotherapy and success of subsequent radiotherapy have been reported and suggest that the response to induction chemotherapy is able to predict a response to radiotherapy. Therefore, induction chemotherapy may be used to tailor the treatment plan to the individual patient with head and neck cancer: following the planned subsequent (chemo)radiation schedule, planning a radiation dose boost, or reassessing the modality of treatment (eg, upfront surgery)...
August 17, 2017: Head & Neck
https://www.readbyqxmd.com/read/28815667/diagnostic-performance-of-unenhanced-computed-tomography-and-18-f-fluorodeoxyglucose-positron-emission-tomography-in-indeterminate-adrenal-tumors
#13
Danae A Delivanis, Irina Bancos, Thomas D Atwell, Grant D Schmit, Patrick W Eiken, Neena Natt, Dana Erickson, Spyridoula Maraka, William F Young, Mark A Nathan
OBJECTIVE: Evidence on the diagnostic performance of adrenal imaging is limited. We aimed to assess the diagnostic performance of unenhanced computed tomography (CT) and(18) F-fluorodeoxyglucose((18) FDG) positron emission tomography(PET)/CT imaging in a high risk population for adrenal malignancy using an optimal reference standard. DESIGN: Retrospective cohort study. METHODS: Imaging studies of patients with adrenal nodules who underwent adrenal biopsy and/or adrenalectomy between 1994 and 2014 were reviewed and compared to the reference standard of histology...
August 17, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28815446/a-human-pet-study-of-11-c-hms011-a-potential-radioligand-for-ampa-receptors
#14
Keisuke Takahata, Yasuyuki Kimura, Chie Seki, Masaki Tokunaga, Masanori Ichise, Kazunori Kawamura, Maiko Ono, Soichiro Kitamura, Manabu Kubota, Sho Moriguchi, Tatsuya Ishii, Yuhei Takado, Fumitoshi Niwa, Hironobu Endo, Tomohisa Nagashima, Yoko Ikoma, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
BACKGROUND: α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor is a primary mediator of fast glutamatergic excitatory signaling in the brain and has been implicated in diverse neuropsychiatric diseases. We recently developed a novel positron emission tomography (PET) ligand, 2-(1-(3-([(11)C]methylamino)phenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl) benzonitrile ([(11)C]HMS011). This compound is a radiolabelled derivative of perampanel, an antiepileptic drug acting on AMPA receptors, and was demonstrated to have promising in vivo properties in the rat and monkey brains...
August 16, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28815414/comparison-of-image-quality-between-step-and-shoot-and-continuous-bed-motion-techniques-in-whole-body-18-f-fluorodeoxyglucose-positron-emission-tomography-with-the-same-acquisition-duration
#15
Shozo Yamashita, Haruki Yamamoto, Tetsu Nakaichi, Tatsuya Yoneyama, Kunihiko Yokoyama
OBJECTIVE: This study aimed to compare the qualities of whole-body positron emission tomography (PET) images acquired by the step-and-shoot (SS) and continuous bed motion (CBM) techniques with approximately the same acquisition duration, through phantom and clinical studies. METHODS: A body phantom with 10-37 mm spheres was filled with (18)F-fluorodeoxyglucose (FDG) solution at a sphere-to-background radioactivity ratio of 4:1 and acquired by both techniques. Reconstructed images were evaluated by visual assessment, percentages of contrast (%Q H) and background variability (%N) in accordance with the Japanese guideline for oncology FDG-PET/computed tomography (CT)...
August 16, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28815337/fluorine-18-fluorodeoxyglucose-positron-emission-tomography-as-an-objective-substitute-for-ct-morphologic-response-criteria-in-patients-undergoing-chemotherapy-for-colorectal-liver-metastases
#16
Yujiro Nishioka, Ryuji Yoshioka, Wataru Gonoi, Toshitaka Sugawara, Shuntaro Yoshida, Masaji Hashimoto, Junichi Shindoh
PURPOSE: The computed tomography (CT) morphologic response of colorectal liver metastases (CLM) after chemotherapy is reportedly correlated with pathologic response and survival outcomes of patients undergoing surgery. However, they are rather subjective criteria and not evaluable without adequate quality of contrast-enhanced CT images. This study sought the potential use of fluorine-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) as an objective substitute for predicting pathological viability of CLM after chemotherapy...
August 16, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28815334/clinical-characteristics-of-patient-selection-and-imaging-predictors-of-outcome-in-solid-tumors-treated-with-checkpoint-inhibitors
#17
REVIEW
Sabrina Rossi, Luca Toschi, Angelo Castello, Fabio Grizzi, Luigi Mansi, Egesta Lopci
The rapidly evolving knowledge on tumor immunology and the continuous implementation of immunotherapy in cancer have recently led to the FDA and EMA approval of several checkpoint inhibitors as immunotherapic agents in clinical practice. Anti-CTLA-4, anti-PD-1, and anti-PDL-1 antibodies are becoming standard of care in advanced melanoma, as well as in relapsed or metastatic lung and kidney cancer, demonstrating higher and longer response compared to standard chemotherapy. These encouraging results have fostered the evaluation of these antibodies either alone or in combination with other therapies in several dozen clinical trials for the treatment of multiple tumor types...
August 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28815223/hepatocellular-carcinoma-when-is-liver-transplantation-oncologically-futile
#18
REVIEW
André Viveiros, Heinz Zoller, Armin Finkenstedt
Selection criteria of patients with hepatocellular carcinoma (HCC) for liver transplantation (LT) have been progressively expanded since the introduction of the Milan criteria. Transplanting patients with unfavourable tumor characteristics increases the risk of tumor recurrence and impacts post-transplant survival. Although tumor number and size are the basis of widely accepted selection criteria and correlate with tumor grading and microvascular invasion, stronger predictors of tumor recurrence have been recently identified...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28814515/fdg-uptake-in-lymphoid-tissue-serves-as-a-predictor-of-disease-outcome-in-the-nonhuman-primate-model-of-monkeypox-infection
#19
Julie Dyall, Reed F Johnson, Svetlana Chefer, Christopher Leyson, David Thomasson, Jurgen Seidel, Dan R Ragland, Russell Byrum, Catherine Jett, Jennifer A Cann, Marisa St Claire, Elaine Jagoda, Richard C Reba, Dima Hammoud, Joseph E Blaney, Peter B Jahrling
Real-time bioimaging of infectious disease processes may aid countermeasure development and lead to an improved understanding of pathogenesis. However, few studies have identified biomarkers for monitoring infections using in vivo imaging. Previously, we demonstrated that positron emission tomography/computed tomography (PET/CT) imaging with [(18)F]-fluorodeoxyglucose (FDG) can monitor monkeypox disease progression in vivo in nonhuman primates (NHPs). In this study, we investigated [(18)F]-FDG-PET/CT imaging of immune processes in lymphoid tissues to identify patterns of inflammation in the monkepox NHP model and to determine the value of [(18)F]-FDG-PET/CT as a biomarker for disease and treatment outcomes...
August 16, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28814253/pet-mr-tomographs-a-review-with-technical-radiochemical-and-clinical-perspectives
#20
Giampiero Giovacchini, Elisabetta Giovannini, Mattia Riondato, Andrea Ciarmiello
In the last decade, an increasing number of positron emission tomography / magnetic resonance (PET/MR) tomographs have been installed and many clinical studies were performed in the neurological field. Although PET/MR has many favorable properties to support the application in brain imaging, attenuation correction, and therefore accurate quantification, is a problem that still requires optimal solution. In this review we have summarized the three main methods that are currently used to correct for attenuation in PET/MR, namely atlas- or template-based methods, segmentation-based methods, and reconstruction-based methods...
August 16, 2017: Current Radiopharmaceuticals
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